TR 346 Rat Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) ETHYL CHLORIDE NTP Experiment-Test: 05078-01 Report: PEIRPT05 Study Type: CHRONIC Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:19 Facility: Battelle Northwest Chemical CAS #: 75-00-3 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:19 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 15000 PP M ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 Early Deaths Moribund Sacrifice 19 24 Natural Death 4 Survivors Terminal Sacrifice 31 22 Animals Examined Microscopically 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Cecum (50) (48) Sarcoma, Metastatic, Bone 1 (2%) Intestine Large, Colon (50) (49) Intestine Small, Ileum (47) (43) Sarcoma, Metastatic, Tissue NOS 1 (2%) Liver (50) (50) Fibrous Histiocytoma, Metastatic, Uncertain Primary Site 1 (2%) Fibrous Histiocytoma, Metastatic, Skeletal Muscle 1 (2%) Hepatocellular Carcinoma 1 (2%) Sarcoma, Metastatic, Bone 1 (2%) Mesentery (1) (2) Schwannoma Malignant, Metastatic, Stomach 1 (50%) Pancreas (49) (50) Fibrous Histiocytoma, Metastatic, Uncertain Primary Site 1 (2%) Sarcoma, Metastatic, Tissue NOS 1 (2%) Schwannoma Malignant, Metastatic, Stomach 1 (2%) Pharynx (2) Palate, Squamous Cell Papilloma 1 (50%) Stomach, Forestomach (46) (50) Schwannoma Malignant 1 (2%) Stomach, Glandular (50) (49) Tongue (1) (1) Squamous Cell Papilloma 1 (100%) 1 (100%) ____________________________________________________________________________________________________________________________________ Page 2 NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:19 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 15000 PP M ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) Fibrous Histiocytoma, Metastatic, Uncertain Primary Site 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland (50) (50) Adrenal Gland, Cortex (50) (50) Adenoma 2 (4%) 1 (2%) Fibrous Histiocytoma, Metastatic, Skeletal Muscle 1 (2%) Sarcoma, Metastatic, Bone 1 (2%) Adrenal Gland, Medulla (35) (40) Pheochromocytoma Malignant 1 (3%) Pheochromocytoma Benign 1 (3%) 2 (5%) Sarcoma, Metastatic, Bone 1 (3%) Islets, Pancreatic (49) (50) Carcinoma 1 (2%) Pituitary Gland (49) (50) Pars Distalis, Adenoma 26 (53%) 30 (60%) Pars Distalis, Carcinoma 6 (12%) 3 (6%) Pars Distalis, Carcinoma, Metastatic, Zymbal's Gland 1 (2%) Thyroid Gland (49) (48) C-Cell, Adenoma 5 (10%) 2 (4%) C-Cell, Carcinoma 3 (6%) 1 (2%) Follicular Cell, Adenoma 1 (2%) Follicular Cell, Carcinoma 2 (4%) 3 (6%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM Tissue NOS (1) Sarcoma 1 (100%) ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (46) (43) Adenoma 1 (2%) 4 (9%) Carcinoma 2 (4%) 1 (2%) Ovary (49) (50) Granulosa Cell Tumor Malignant 1 (2%) Uterus (49) (50) Polyp Stromal 2 (4%) 7 (14%) Page 3 NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:19 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 15000 PP M ____________________________________________________________________________________________________________________________________ ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) Sarcoma, Metastatic, Bone 1 (2%) Lymph Node (48) (49) Lymph Node, Bronchial (47) (47) Fibrous Histiocytoma, Metastatic, Uncertain Primary Site 1 (2%) Fibrous Histiocytoma, Metastatic, Skeletal Muscle 1 (2%) Sarcoma, Metastatic, Bone 1 (2%) Mesenteric, Sarcoma, Metastatic, Tissue NOS 1 (2%) Lymph Node, Mandibular (39) (43) Spleen (50) (50) Fibrous Histiocytoma, Metastatic 1 (2%) Hemangiosarcoma 1 (2%) Thymus (38) (39) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (48) (50) Adenocarcinoma 1 (2%) Adenoma 2 (4%) 1 (2%) Fibroadenoma 11 (23%) 8 (16%) Fibroadenoma, Multiple 1 (2%) 1 (2%) Skin (47) (49) Basal Cell Carcinoma 1 (2%) Subcutaneous Tissue, Fibroma 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) Fibrous Histiocytoma, Metastatic, Skeletal Muscle 1 (2%) Osteosarcoma 1 (2%) Skeletal Muscle (1) Fibrous Histiocytoma 1 (100%) ____________________________________________________________________________________________________________________________________ Page 4 NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:19 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 15000 PP M ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) Astrocytoma Malignant 3 (6%) Carcinoma, Metastatic, Pituitary Gland 5 (10%) 2 (4%) Meninges, Carcinoma, Metastatic, Zymbal's Gland 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (50) (49) Lung (50) (50) Basal Cell Carcinoma, Metastatic, Skin 1 (2%) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Fibrous Histiocytoma, Metastatic, Uncertain Primary Site 1 (2%) Fibrous Histiocytoma, Metastatic, Skeletal Muscle 1 (2%) Sarcoma, Metastatic, Bone 1 (2%) Sarcoma, Metastatic, Ear 1 (2%) Nose (50) (50) Trachea (50) (49) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Ear (2) Sarcoma 1 (50%) Eye (3) (5) Zymbal's Gland (2) Adenoma 1 (50%) Carcinoma 1 (50%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) Fibrous Histiocytoma, Metastatic, Uncertain Primary Site 1 (2%) Sarcoma, Metastatic, Bone 1 (2%) Urinary Bladder (49) (49) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) Leukemia Lymphocytic 1 (2%) * Number of animals with any tissue examined microscopically Page 5 NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:19 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 15000 PP M ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont Multiple Organs *(50) *(50) Leukemia Mononuclear 20 (40%) 25 (50%) Lymphoma Malignant Undifferentiated Cell 1 (2%) ____________________________________________________________________________________________________________________________________ Page 6 NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:19 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 15000 PP M ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 45 48 Total Primary Neoplasms 95 105 Total Animals with Benign Neoplasms 37 38 Total Benign Neoplasms 56 60 Total Animals with Malignant Neoplasms 33 35 Total Malignant Neoplasms 39 45 Total Animals with Metastatic Neoplasms 8 8 Total Metastatic Neoplasm 17 20 Total Animals with Malignant Neoplasms 1 Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 7 NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:19 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 15000 PP M ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 Early Deaths Moribund Sacrifice 28 33 Natural Death 6 9 Survivors Terminal Sacrifice 16 8 Animals Examined Microscopically 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (50) (45) Liver (50) (50) Hepatocellular Carcinoma 1 (2%) Neoplastic Nodule, Multiple 1 (2%) Mesentery (1) (1) Pancreas (50) (49) Stomach (50) (50) Stomach, Forestomach (48) (49) Squamous Cell Papilloma 1 (2%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) Schwannoma NOS 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland, Cortex (50) (50) Adenoma 1 (2%) Adrenal Gland, Medulla (36) (48) Pheochromocytoma Malignant 1 (2%) Pheochromocytoma Benign 7 (19%) 2 (4%) Bilateral, Pheochromocytoma Benign 1 (3%) 7 (15%) Islets, Pancreatic (48) (48) Adenoma 6 (13%) 2 (4%) Adenoma, Multiple 1 (2%) Parathyroid Gland (31) (41) Adenoma 1 (3%) Pituitary Gland (49) (50) Pars Distalis, Adenoma 31 (63%) 25 (50%) Pars Distalis, Carcinoma 1 (2%) Page 8 NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:19 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 15000 PP M ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont Pars Intermedia, Adenoma 1 (2%) Thyroid Gland (49) (47) C-Cell, Adenoma 6 (12%) 1 (2%) C-Cell, Adenoma, Multiple 1 (2%) C-Cell, Carcinoma 2 (4%) Follicular Cell, Carcinoma 2 (4%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM Tissue NOS (1) (4) Chordoma 1 (25%) Sarcoma 1 (25%) ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Preputial Gland (47) (45) Adenoma 1 (2%) 1 (2%) Carcinoma 1 (2%) 2 (4%) Prostate (50) (48) Sarcoma, Metastatic, Uncertain Primary Site 1 (2%) Seminal Vesicle (7) (6) Sarcoma, Metastatic, Uncertain Primary Site 1 (17%) Testes (50) (50) Bilateral, Interstitial Cell, Adenoma 19 (38%) 8 (16%) Interstitial Cell, Adenoma 10 (20%) 17 (34%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (48) Lymph Node (49) (50) Sarcoma, Metastatic, Uncertain Primary Site 1 (2%) Lymph Node, Bronchial (42) (48) Lymph Node, Mandibular (45) (38) Spleen (50) (50) Hemangioma 1 (2%) Thymus (39) (41) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (13) (14) Fibroadenoma 1 (8%) Skin (49) (46) Basal Cell Carcinoma 3 (7%) Page 9 NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:19 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 15000 PP M ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont Keratoacanthoma 4 (8%) 2 (4%) Squamous Cell Carcinoma 1 (2%) Trichoepithelioma 1 (2%) Lip, Squamous Cell Carcinoma 1 (2%) Sebaceous Gland, Adenoma 1 (2%) Subcutaneous Tissue, Fibroma 1 (2%) 2 (4%) Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%) Subcutaneous Tissue, Lipoma 1 (2%) Subcutaneous Tissue, Neurofibrosarcoma 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) Astrocytoma Malignant 1 (2%) Granular Cell Tumor Malignant 1 (2%) Oligodendroglioma Benign 1 (2%) Oligodendroglioma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (49) (44) Lung (50) (50) Sarcoma, Metastatic 1 (2%) Squamous Cell Carcinoma 1 (2%) Nose (50) (49) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Zymbal's Gland (1) Carcinoma 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) Lipoma, Moderate 1 (2%) Renal Tubule, Carcinoma 1 (2%) Urinary Bladder (50) (49) Page 10 NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:19 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 15000 PP M ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont Sarcoma, Metastatic, Uncertain Primary Site 1 (2%) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) Leukemia Mononuclear 33 (66%) 36 (72%) Lymphoma Malignant Histiocytic 1 (2%) Mesothelioma Benign 1 (2%) Mesothelioma Malignant 2 (4%) 3 (6%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 11 NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:19 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 15000 PP M ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 49 48 Total Primary Neoplasms 142 127 Total Animals with Benign Neoplasms 46 44 Total Benign Neoplasms 95 73 Total Animals with Malignant Neoplasms 39 40 Total Malignant Neoplasms 46 54 Total Animals with Metastatic Neoplasms 1 3 Total Metastatic Neoplasm 4 13 Total Animals with Malignant Neoplasms 1 Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant 1 Total Uncertain Neoplasms 1 ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 12 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------ --multipart-boundary Content-type: text/plain Range: bytes 67909-67909/67909 --multipart-boundary--