TR 346 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest ETHYL CHLORIDE DATE: 09/10/94
EXPERIMENT: 05078 TEST: 01 TIME: 13:13:45
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01ES38061 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 06224
PATHOLOGIST: R. MILLER CAS: 75-00-3
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest ETHYL CHLORIDE DATE: 09/10/94
EXPERIMENT: 05078 TEST: 01 TIME: 13:13:45
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES38061 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 06224
PATHOLOGIST: R. MILLER CAS: 75-00-3
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Larynx
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest ETHYL CHLORIDE DATE: 09/10/94
EXPERIMENT: 05078 TEST: 01 TIME: 13:13:45
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES38061 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 06224
PATHOLOGIST: R. MILLER CAS: 75-00-3
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF ETHYL CHLORIDE
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Skin Trichoepithelioma, Basal Cell Carcinoma, or Basal Cell Adenoma
Thyroid Gland: C-Cell Adenoma
Carcinoma or Adenoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear,
or Undifferentiated
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Uterus Polyp Stromal
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear,
or Undifferentiated
Benign Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) | 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 6.3% 0.0% | 5.9% 4.5% |
|TERMINAL (d) | 1/16 (6%) 0/8 (0%) | 1/31 (3%) 1/22 (5%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- | 661 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.638N | P=0.600N |
|INCIDENTAL TUMOR | P=0.638N | P=0.579N |
|LOGISTIC REGRESSION | P=0.638N | P=0.555N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500N | P=0.500N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/36 (22%) 9/48 (19%) | 1/35 (3%) 2/40 (5%) |
|ADJUSTED (b) | 48.9% 56.2% | 5.6% 12.5% |
|TERMINAL (d) | 6/13 (46%) 3/7 (43%) | 1/18 (6%) 2/16 (13%) |
|FIRST INCIDENCE (DAYS) | 500 562 | 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.175 | P=0.458 |
|INCIDENTAL TUMOR | P=0.418 | P=0.458 |
|LOGISTIC REGRESSION | P=0.589N | P=0.458 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.450N | P=0.551 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/36 (22%) 10/48 (21%) | 1/35 (3%) 3/40 (8%) |
|ADJUSTED (b) | 48.9% 57.5% | 5.6% 18.8% |
|TERMINAL (d) | 6/13 (46%) 3/7 (43%) | 1/18 (6%) 3/16 (19%) |
|FIRST INCIDENCE (DAYS) | 500 562 | 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.119 | P=0.258 |
|INCIDENTAL TUMOR | P=0.367 | P=0.258 |
|LOGISTIC REGRESSION | P=0.549 | P=0.258 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.543N | P=0.360 |
|=================================================================================================================================|
| |
|Brain |
| Astrocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) | 0/50 (0%) 3/50 (6%) |
|ADJUSTED (b) | 0.0% 12.5% | 0.0% 9.1% |
|TERMINAL (d) | 0/16 (0%) 1/8 (13%) | 0/31 (0%) 0/22 (0%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) | --- 364 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.362 | P=0.095 |
|INCIDENTAL TUMOR | P=0.362 | P=0.119 |
|LOGISTIC REGRESSION | P=0.362 | P=0.128 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500 | P=0.121 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|Brain |
| Oligodendroglioma, Glioma, or Astrocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) | 0/50 (0%) 3/50 (6%) |
|ADJUSTED (b) | 2.4% 15.6% | 0.0% 9.1% |
|TERMINAL (d) | 0/16 (0%) 1/8 (13%) | 0/31 (0%) 0/22 (0%) |
|FIRST INCIDENCE (DAYS) | 567 633 | --- 364 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.388 | P=0.095 |
|INCIDENTAL TUMOR | P=0.657 | P=0.119 |
|LOGISTIC REGRESSION | P=0.507 | P=0.128 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500 | P=0.121 |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/47 (2%) 1/45 (2%) | 1/46 (2%) 4/43 (9%) |
|ADJUSTED (b) | 6.3% 6.7% | 3.3% 16.3% |
|TERMINAL (d) | 1/16 (6%) 0/6 (0%) | 1/30 (3%) 2/21 (10%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 709 | 729 (T) 672 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.633 | P=0.105 |
|INCIDENTAL TUMOR | P=0.666 | P=0.106 |
|LOGISTIC REGRESSION | P=0.679 | P=0.106 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.742 | P=0.160 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/47 (2%) 2/45 (4%) | 2/46 (4%) 1/43 (2%) |
|ADJUSTED (b) | 4.3% 19.6% | 5.4% 4.8% |
|TERMINAL (d) | 0/16 (0%) 1/6 (17%) | 1/30 (3%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | 692 633 | 568 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.345 | P=0.592N |
|INCIDENTAL TUMOR | P=0.501 | P=0.531N |
|LOGISTIC REGRESSION | P=0.440 | P=0.516N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.484 | P=0.526N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/47 (4%) 3/45 (7%) | 3/46 (7%) 5/43 (12%) |
|ADJUSTED (b) | 10.3% 25.0% | 8.7% 20.7% |
|TERMINAL (d) | 1/16 (6%) 1/6 (17%) | 2/30 (7%) 3/21 (14%) |
|FIRST INCIDENCE (DAYS) | 692 633 | 568 672 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.284 | P=0.216 |
|INCIDENTAL TUMOR | P=0.419 | P=0.250 |
|LOGISTIC REGRESSION | P=0.394 | P=0.254 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.479 | P=0.319 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/48 (13%) 3/48 (6%) | 0/49 (0%) 0/50 (0%) |
|ADJUSTED (b) | 26.2% 21.7% | 0.0% 0.0% |
|TERMINAL (d) | 2/15 (13%) 1/8 (13%) | 0/30 (0%) 0/22 (0%) |
|FIRST INCIDENCE (DAYS) | 570 701 | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.411N | (e) (e) |
|INCIDENTAL TUMOR | P=0.313N | (e) (e) |
|LOGISTIC REGRESSION | P=0.310N | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.243N | (e) |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/48 (13%) 3/48 (6%) | 1/49 (2%) 0/50 (0%) |
|ADJUSTED (b) | 26.2% 21.7% | 3.3% 0.0% |
|TERMINAL (d) | 2/15 (13%) 1/8 (13%) | 1/30 (3%) 0/22 (0%) |
|FIRST INCIDENCE (DAYS) | 570 701 | 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.411N | P=0.562N |
|INCIDENTAL TUMOR | P=0.313N | P=0.562N |
|LOGISTIC REGRESSION | P=0.310N | P=0.562N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.243N | P=0.495N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|Mammary Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) | 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 0.0% | 6.5% 4.5% |
|TERMINAL (d) | 0/16 (0%) 0/8 (0%) | 2/31 (6%) 1/22 (5%) |
|FIRST INCIDENCE (DAYS) | --- --- | 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) | P=0.620N |
|INCIDENTAL TUMOR | (e) (e) | P=0.620N |
|LOGISTIC REGRESSION | (e) (e) | P=0.620N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | (e) | P=0.500N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) | 2/50 (4%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% | 6.5% 9.1% |
|TERMINAL (d) | 0/16 (0%) 0/8 (0%) | 2/31 (6%) 2/22 (9%) |
|FIRST INCIDENCE (DAYS) | --- --- | 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) | P=0.567 |
|INCIDENTAL TUMOR | (e) (e) | P=0.567 |
|LOGISTIC REGRESSION | (e) (e) | P=0.567 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | (e) | P=0.691N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) | 11/50 (22%) 8/50 (16%) |
|ADJUSTED (b) | 2.0% 0.0% | 28.1% 27.1% |
|TERMINAL (d) | 0/16 (0%) 0/8 (0%) | 6/31 (19%) 3/22 (14%) |
|FIRST INCIDENCE (DAYS) | 485 --- | 545 574 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.517N | P=0.540N |
|INCIDENTAL TUMOR | P=0.557N | P=0.263N |
|LOGISTIC REGRESSION | P=0.304N | P=0.304N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500N | P=0.306N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) | 13/50 (26%) 8/50 (16%) |
|ADJUSTED (b) | 2.0% 0.0% | 33.9% 27.1% |
|TERMINAL (d) | 0/16 (0%) 0/8 (0%) | 8/31 (26%) 3/22 (14%) |
|FIRST INCIDENCE (DAYS) | 485 --- | 545 574 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.517N | P=0.386N |
|INCIDENTAL TUMOR | P=0.557N | P=0.154N |
|LOGISTIC REGRESSION | P=0.304N | P=0.173N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500N | P=0.163N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) | 13/50 (26%) 9/50 (18%) |
|ADJUSTED (b) | 2.0% 0.0% | 33.9% 31.0% |
|TERMINAL (d) | 0/16 (0%) 0/8 (0%) | 8/31 (26%) 4/22 (18%) |
|FIRST INCIDENCE (DAYS) | 485 --- | 545 574 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.517N | P=0.493N |
|INCIDENTAL TUMOR | P=0.557N | P=0.236N |
|LOGISTIC REGRESSION | P=0.304N | P=0.255N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500N | P=0.235N |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip) |
| Papilloma Squamous or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) | 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% | 2.9% 6.9% |
|TERMINAL (d) | 0/16 (0%) 0/8 (0%) | 0/31 (0%) 1/22 (5%) |
|FIRST INCIDENCE (DAYS) | --- --- | 688 574 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) | P=0.425 |
|INCIDENTAL TUMOR | (e) (e) | P=0.539 |
|LOGISTIC REGRESSION | (e) (e) | P=0.510 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | (e) | P=0.500 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip) |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) | 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% | 2.9% 6.9% |
|TERMINAL (d) | 0/16 (0%) 0/8 (0%) | 0/31 (0%) 1/22 (5%) |
|FIRST INCIDENCE (DAYS) | --- --- | 688 574 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) | P=0.425 |
|INCIDENTAL TUMOR | (e) (e) | P=0.539 |
|LOGISTIC REGRESSION | (e) (e) | P=0.510 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | (e) | P=0.500 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 31/49 (63%) 25/50 (50%) | 26/49 (53%) 30/50 (60%) |
|ADJUSTED (b) | 83.3% 84.6% | 65.7% 77.2% |
|TERMINAL (d) | 10/15 (67%) 5/8 (63%) | 18/31 (58%) 14/22 (64%) |
|FIRST INCIDENCE (DAYS) | 485 519 | 540 490 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.457 | P=0.044 * |
|INCIDENTAL TUMOR | P=0.137N | P=0.240 |
|LOGISTIC REGRESSION | P=0.158N | P=0.250 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.129N | P=0.311 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 0/50 (0%) | 6/49 (12%) 3/50 (6%) |
|ADJUSTED (b) | 6.7% 0.0% | 14.8% 10.7% |
|TERMINAL (d) | 1/15 (7%) 0/8 (0%) | 1/31 (3%) 1/22 (5%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- | 545 629 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.625N | P=0.380N |
|INCIDENTAL TUMOR | P=0.625N | P=0.143N |
|LOGISTIC REGRESSION | P=0.625N | P=0.180N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.495N | P=0.233N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 32/49 (65%) 25/50 (50%) | 32/49 (65%) 33/50 (66%) |
|ADJUSTED (b) | 86.7% 84.6% | 72.2% 81.4% |
|TERMINAL (d) | 11/15 (73%) 5/8 (63%) | 19/31 (61%) 15/22 (68%) |
|FIRST INCIDENCE (DAYS) | 485 519 | 540 490 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.498 | P=0.099 |
|INCIDENTAL TUMOR | P=0.106N | P=0.548 |
|LOGISTIC REGRESSION | P=0.116N | P=0.526 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.090N | P=0.555 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 01 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 3/50 (6%) | 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 25.6% | 0.0% 4.5% |
|TERMINAL (d) | 0/16 (0%) 1/8 (13%) | 0/31 (0%) 1/22 (5%) |
|FIRST INCIDENCE (DAYS) | --- 678 | --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.055 | P=0.432 |
|INCIDENTAL TUMOR | P=0.078 | P=0.432 |
|LOGISTIC REGRESSION | P=0.083 | P=0.432 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.121 | P=0.500 |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 19.5% 15.0% | 0.0% 0.0% |
|TERMINAL (d) | 2/16 (13%) 0/8 (0%) | 0/31 (0%) 0/22 (0%) |
|FIRST INCIDENCE (DAYS) | 682 678 | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.531N | (e) (e) |
|INCIDENTAL TUMOR | P=0.460N | (e) (e) |
|LOGISTIC REGRESSION | P=0.423N | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.339N | (e) |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 01 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 7.6% | 0.0% 0.0% |
|TERMINAL (d) | 0/16 (0%) 0/8 (0%) | 0/31 (0%) 0/22 (0%) |
|FIRST INCIDENCE (DAYS) | --- 577 | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.251 | (e) (e) |
|INCIDENTAL TUMOR | P=0.340 | (e) (e) |
|LOGISTIC REGRESSION | P=0.243 | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.247 | (e) |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Basal Cell Carcinoma, or Basal Cell Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 4/50 (8%) | 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 31.8% | 0.0% 4.5% |
|TERMINAL (d) | 0/16 (0%) 1/8 (13%) | 0/31 (0%) 1/22 (5%) |
|FIRST INCIDENCE (DAYS) | --- 678 | --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.023 * | P=0.432 |
|INCIDENTAL TUMOR | P=0.039 * | P=0.432 |
|LOGISTIC REGRESSION | P=0.036 * | P=0.432 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.059 | P=0.500 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 01 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 7/50 (14%) | 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 19.5% 39.8% | 0.0% 4.5% |
|TERMINAL (d) | 2/16 (13%) 1/8 (13%) | 0/31 (0%) 1/22 (5%) |
|FIRST INCIDENCE (DAYS) | 682 577 | --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.122 | P=0.432 |
|INCIDENTAL TUMOR | P=0.185 | P=0.432 |
|LOGISTIC REGRESSION | P=0.183 | P=0.432 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.262 | P=0.500 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) | 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 2.2% 5.2% | 3.2% 4.5% |
|TERMINAL (d) | 0/16 (0%) 0/8 (0%) | 1/31 (3%) 1/22 (5%) |
|FIRST INCIDENCE (DAYS) | 526 552 | 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.487 | P=0.684 |
|INCIDENTAL TUMOR | P=0.698 | P=0.684 |
|LOGISTIC REGRESSION | P=0.601 | P=0.684 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500 | P=0.753N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 01 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) | 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 2.2% 9.3% | 3.2% 4.5% |
|TERMINAL (d) | 0/16 (0%) 0/8 (0%) | 1/31 (3%) 1/22 (5%) |
|FIRST INCIDENCE (DAYS) | 526 552 | 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.288 | P=0.684 |
|INCIDENTAL TUMOR | P=0.455 | P=0.684 |
|LOGISTIC REGRESSION | P=0.366 | P=0.684 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.309 | P=0.753N |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 29/50 (58%) 25/50 (50%) | |
|ADJUSTED (b) | 89.5% 90.3% | |
|TERMINAL (d) | 13/16 (81%) 6/8 (75%) | |
|FIRST INCIDENCE (DAYS) | 500 479 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.240 | |
|INCIDENTAL TUMOR | P=0.449N | |
|LOGISTIC REGRESSION | P=0.417N | |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.274N | |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 01 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/49 (14%) 1/47 (2%) | 5/49 (10%) 2/48 (4%) |
|ADJUSTED (b) | 33.4% 6.7% | 16.1% 9.1% |
|TERMINAL (d) | 4/16 (25%) 0/8 (0%) | 5/31 (16%) 2/22 (9%) |
|FIRST INCIDENCE (DAYS) | 587 709 | 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.095N | P=0.370N |
|INCIDENTAL TUMOR | P=0.060N | P=0.370N |
|LOGISTIC REGRESSION | P=0.052N | P=0.370N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.034N* | P=0.226N |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 0/47 (0%) | 3/49 (6%) 1/48 (2%) |
|ADJUSTED (b) | 9.0% 0.0% | 8.9% 3.1% |
|TERMINAL (d) | 1/16 (6%) 0/8 (0%) | 2/31 (6%) 0/22 (0%) |
|FIRST INCIDENCE (DAYS) | 654 --- | 659 643 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.353N | P=0.416N |
|INCIDENTAL TUMOR | P=0.321N | P=0.305N |
|LOGISTIC REGRESSION | P=0.270N | P=0.330N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.258N | P=0.316N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 01 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/49 (18%) 1/47 (2%) | 8/49 (16%) 3/48 (6%) |
|ADJUSTED (b) | 40.8% 6.7% | 24.6% 11.9% |
|TERMINAL (d) | 5/16 (31%) 0/8 (0%) | 7/31 (23%) 2/22 (9%) |
|FIRST INCIDENCE (DAYS) | 587 709 | 659 643 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.044N* | P=0.233N |
|INCIDENTAL TUMOR | P=0.023N* | P=0.179N |
|LOGISTIC REGRESSION | P=0.017N* | P=0.171N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.009N** | P=0.106N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 0/47 (0%) | 2/49 (4%) 3/48 (6%) |
|ADJUSTED (b) | 12.5% 0.0% | 6.5% 12.7% |
|TERMINAL (d) | 2/16 (13%) 0/8 (0%) | 2/31 (6%) 2/22 (9%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- | 729 (T) 707 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.399N | P=0.355 |
|INCIDENTAL TUMOR | P=0.399N | P=0.377 |
|LOGISTIC REGRESSION | P=0.399N | P=0.380 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.258N | P=0.490 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 01 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 0/47 (0%) | 3/49 (6%) 3/48 (6%) |
|ADJUSTED (b) | 12.5% 0.0% | 8.7% 12.7% |
|TERMINAL (d) | 2/16 (13%) 0/8 (0%) | 2/31 (6%) 2/22 (9%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- | 643 707 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.399N | P=0.513 |
|INCIDENTAL TUMOR | P=0.399N | P=0.609 |
|LOGISTIC REGRESSION | P=0.399N | P=0.578 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.258N | P=0.651 |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # |
|----------- | | |
|OVERALL (a) | | 2/50 (4%) 7/50 (14%) |
|ADJUSTED (b) | | 5.2% 23.1% |
|TERMINAL (d) | | 1/31 (3%) 3/22 (14%) |
|FIRST INCIDENCE (DAYS) | | 540 573 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.045 * |
|INCIDENTAL TUMOR | | P=0.118 |
|LOGISTIC REGRESSION | | P=0.088 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | | P=0.080 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 01 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) | 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 2.1% 0.0% | 0.0% 6.3% |
|TERMINAL (d) | 0/16 (0%) 0/8 (0%) | 0/31 (0%) 0/22 (0%) |
|FIRST INCIDENCE (DAYS) | 512 --- | --- 622 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.508N | P=0.197 |
|INCIDENTAL TUMOR | P=0.557N | P=0.314 |
|LOGISTIC REGRESSION | P=0.373N | P=0.247 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500N | P=0.247 |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, |
| or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 33/50 (66%) 36/50 (72%) | 20/50 (40%) 26/50 (52%) |
|ADJUSTED (b) | 87.6% 96.9% | 48.1% 77.5% |
|TERMINAL (d) | 12/16 (75%) 7/8 (88%) | 10/31 (32%) 15/22 (68%) |
|FIRST INCIDENCE (DAYS) | 517 437 | 574 535 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.046 * | P=0.025 * |
|INCIDENTAL TUMOR | P=0.310 | P=0.110 |
|LOGISTIC REGRESSION | P=0.214 | P=0.090 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.333 | P=0.158 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 01 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 3/50 (6%) | 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 15.3% 11.9% | 0.0% 0.0% |
|TERMINAL (d) | 2/16 (13%) 0/8 (0%) | 0/31 (0%) 0/22 (0%) |
|FIRST INCIDENCE (DAYS) | 665 577 | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.509 | (e) (e) |
|INCIDENTAL TUMOR | P=0.632N | (e) (e) |
|LOGISTIC REGRESSION | P=0.633 | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.661N | (e) |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 46/50 (92%) 44/50 (88%) | 37/50 (74%) 38/50 (76%) |
|ADJUSTED (b) | 97.8% 100.0% | 85.6% 94.7% |
|TERMINAL (d) | 15/16 (94%) 8/8 (100%) | 25/31 (81%) 20/22 (91%) |
|FIRST INCIDENCE (DAYS) | 485 479 | 540 490 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.117 | P=0.048 * |
|INCIDENTAL TUMOR | P=0.317N | P=0.344 |
|LOGISTIC REGRESSION | P=0.558N | P=0.348 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.370N | P=0.500 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 01 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15000 PP | CONTROL 15000 PP |
| | M | M |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 39/50 (78%) 40/50 (80%) | 33/50 (66%) 36/50 (72%) |
|ADJUSTED (b) | 92.0% 97.3% | 68.7% 85.1% |
|TERMINAL (d) | 13/16 (81%) 7/8 (88%) | 16/31 (52%) 16/22 (73%) |
|FIRST INCIDENCE (DAYS) | 512 437 | 251 364 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.082 | P=0.063 |
|INCIDENTAL TUMOR | P=0.547 | P=0.402 |
|LOGISTIC REGRESSION | P=0.408 | P=0.388 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500 | P=0.333 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 49/50 (98%) 48/50 (96%) | 45/50 (90%) 49/50 (98%) |
|ADJUSTED (b) | 100.0% 100.0% | 90.0% 100.0% |
|TERMINAL (d) | 16/16 (100%) 8/8 (100%) | 26/31 (84%) 22/22 (100%) |
|FIRST INCIDENCE (DAYS) | 485 437 | 251 364 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.094 | P=0.017 * |
|INCIDENTAL TUMOR | P=0.574N | P=0.142 |
|LOGISTIC REGRESSION | P=0.616N | P=0.127 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500N | P=0.102 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05078 TEST: 01 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYL CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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