TR 346 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 09/10/94
EXP: 05078 ETHYL CHLORIDE TIME: 13:14:15
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 06224
CONT: N01ES38061 CAS: 75-00-3
PATHOLOGIST: R. MILLER
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
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REMOVAL DATE RANGE:
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NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 09/10/94
EXP: 05078 ETHYL CHLORIDE TIME: 13:14:15
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 06224
CONT: N01ES38061 CAS: 75-00-3
PATHOLOGIST: R. MILLER
ETHYL CHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 34 CENSORED DEATHS 0 TERMINAL 16 |
| |
| UNCENSORED DEATHS |
| 485 500 512 517 526 526 542 545 567 570 |
| 570 587 611 641 645 646 654 654 658 665 |
| 668 671 672 675 682 682 689 692 696 696 |
| 698 699 717 720 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 15000 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 42 CENSORED DEATHS 0 TERMINAL 8 |
| |
| UNCENSORED DEATHS |
| 414 437 471 479 519 526 549 552 562 577 |
| 577 581 587 587 602 608 611 613 621 626 |
| 626 626 633 646 646 664 671 678 678 689 |
| 700 701 704 706 707 709 709 713 716 717 |
| 727 728 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ETHYL CHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 98.0 84.0 76.0 60.0 32.0 |
| | |
| | |
|15000 PPM | 100.0 100.0 100.0 100.0 98.0 92.0 88.0 70.0 48.0 16.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 15000 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 32.0% 16.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.161 P=0.161 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 625.8 623.6 |
|NATURAL DEATHS (C) | (12.4) (12.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 658.8 640.5 |
|(STANDARD ERROR) | (10.8) (12.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ETHYL CHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 251 540 545 568 574 587 611 630 633 643 |
| 654 657 659 659 661 668 688 703 716 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 15000 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 28 CENSORED DEATHS 0 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 364 490 535 545 546 559 563 573 573 574 |
| 588 594 599 608 612 622 623 629 643 650 |
| 672 679 688 688 689 707 714 720 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ETHYL CHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 98.0 98.0 98.0 98.0 94.0 88.0 70.0 62.0 |
| | |
| | |
|15000 PPM | 100.0 100.0 100.0 98.0 98.0 98.0 92.0 74.0 60.0 44.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 15000 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 62.0% 44.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.083 P=0.083 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 613.0 608.8 |
|NATURAL DEATHS (C) | (23.2) (14.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 684.9 661.7 |
|(STANDARD ERROR) | (11.8) (11.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ETHYL CHLORIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
15000 PPM = 2
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1
| 2 2 1 1
| 2 22 1 1
| 2 1 21
90 + 22
| 1 12
| 12 1
| 112
80 +
| 1 1
P | 21 1 1
E | 2 2 11
R 70 + 22
C | 22 11
E | 22
N | 22 1 1
T 60 + 11
|
S | 22 2 11
U | 11
R 50 + 2 2
V | 22 11
I | 22 11
V | 2 2
A 40 + 22
L | 22
| 1 1
| 1 1
30 + 22
|
| 22
|
20 + 22
|
| 2 2
|
10 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 8 obs hidden.
ETHYL CHLORIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
15000 PPM = 2
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2
| 1 2 2 1
| 2 21 1
|
P 90 + 2 2 1 1
E | 22 1 1
R | 22 1 11
C | 11
E 80 + 2 2 1 1
N | 2 2
T | 222 1 1
| 22
S 70 + 22 11
U | 1 1
R | 22 2 1 1 1
V | 22 1 1
I 60 + 2 2
V | 22
A | 2 2
L |
50 + 2 2
| 22
| 22 2
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 8 obs hidden.
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