TR 349 Mouse Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
TECHNICAL GRADE PENTACHLOROPHENOL
NTP Experiment-Test: 05073-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/09/94
Route: DOSED FEED Time: 05:28:03
Facility: Battelle Columbus Laboratory
Chemical CAS #: 87-86-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05073-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TECHNICAL GRADE PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 05:28:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 100 PPM 200 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 35 50 50
Early Deaths
Natural Death 6 8 13
Moribund Sacrifice 1 5
Survivors
Terminal Sacrifice 28 41 30
Natural Death 1 2
Animals Examined Microscopically 35 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (32) (3) (47)
Parasite Metazoan 1 (2%)
Intestine Small, Duodenum (32) (3) (47)
Mineralization 1 (2%)
Liver (33) (49) (50)
Basophilic Focus 1 (3%) 5 (10%)
Clear Cell Focus 1 (3%) 3 (6%) 7 (14%)
Clear Cell Focus, Multiple 10 (20%)
Degeneration, Cystic 1 (3%) 1 (2%)
Hematopoietic Cell Proliferation, Multifocal 14 (42%) 8 (16%) 33 (66%)
Hyperplasia 3 (6%)
Infarct 4 (12%) 2 (4%) 2 (4%)
Inflammation, Chronic Active, Diffuse 34 (69%) 44 (88%)
Pigmentation, Multifocal 37 (76%) 47 (94%)
Vacuolization Cytoplasmic 1 (3%) 3 (6%)
Bile Duct, Hyperplasia, Multifocal 1 (2%) 2 (4%)
Bile Duct, Inflammation, Chronic Active,
Multifocal 1 (2%)
Hepatocyte, Cytomegaly, Diffuse 48 (98%) 48 (96%)
Hepatocyte, Necrosis, Acute, Diffuse 44 (90%) 47 (94%)
Mesentery (3) (1)
Inflammation, Chronic 1 (33%)
Pancreas (31) (4) (48)
Acinus, Atrophy 4 (13%) 6 (13%)
Acinus, Inflammation, Chronic 1 (2%)
Duct, Cyst 2 (4%)
Salivary Glands (33) (4) (47)
Hyperplasia, Lymphoid 1 (2%)
Stomach, Forestomach (32) (3) (46)
Acanthosis 4 (13%) 3 (7%)
Erosion 1 (2%)
Inflammation, Chronic Active 3 (9%) 1 (2%)
Ulcer, Acute 2 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05073-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TECHNICAL GRADE PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 05:28:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 100 PPM 200 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Stomach, Glandular (32) (3) (47)
Dysplasia 1 (3%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (35) (4) (50)
Mineralization 1 (2%)
Perivascular, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (34) (48) (49)
Capsule, Hyperplasia 33 (97%) 48 (100%) 49 (100%)
Adrenal Gland, Cortex (33) (48) (49)
Atrophy 1 (2%)
Degeneration, Fatty 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 2 (4%)
Hyperplasia 1 (3%) 2 (4%) 3 (6%)
Hypertrophy 1 (3%) 2 (4%) 4 (8%)
Adrenal Gland, Medulla (33) (48) (49)
Hyperplasia 4 (8%) 2 (4%)
Parathyroid Gland (30) (4) (35)
Infiltration Cellular, Lymphocyte 1 (3%)
Pituitary Gland (32) (14) (39)
Pars Distalis, Cyst 1 (3%) 1 (7%)
Pars Distalis, Hyperplasia 10 (31%) 4 (29%) 10 (26%)
Thyroid Gland (33) (4) (48)
Inflammation, Chronic 3 (9%)
Follicular Cell, Hyperplasia 7 (21%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (30) (23) (48)
Angiectasis 1 (2%)
Inflammation, Chronic Active 1 (4%) 1 (2%)
Mineralization 1 (4%)
Follicle, Cyst 8 (27%) 9 (39%) 15 (31%)
Periovarian Tissue, Cyst 2 (7%) 10 (43%) 3 (6%)
Uterus (33) (37) (48)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05073-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TECHNICAL GRADE PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 05:28:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 100 PPM 200 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Inflammation, Chronic Active 1 (3%)
Endometrium, Hyperplasia, Cystic, Glandular,
Multifocal 28 (85%) 35 (95%) 35 (73%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (2)
Leukocytosis 1 (50%)
Neutrophilia 1 (50%)
Bone Marrow (35) (4) (49)
Femoral, Hyperplasia, Neutrophil 2 (4%)
Femoral, Myelofibrosis 8 (23%) 1 (25%) 15 (31%)
Sternal, Myelofibrosis 2 (4%)
Lymph Node (33) (12) (46)
Mesenteric, Hematopoietic Cell Proliferation 1 (3%) 3 (25%) 2 (4%)
Mesenteric, Hemorrhage 1 (2%)
Lymph Node, Mandibular (33) (4) (45)
Angiectasis 1 (2%)
Depletion Lymphoid 1 (3%)
Hyperplasia 1 (2%)
Hyperplasia, Lymphoid 3 (7%)
Spleen (33) (13) (47)
Atrophy 1 (2%)
Depletion Lymphoid 2 (6%) 1 (8%)
Hematocyst 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Red Pulp, Hematopoietic Cell Proliferation,
Diffuse 2 (6%) 4 (31%) 11 (23%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (30) (3) (34)
Hyperplasia, Cystic 7 (23%) 20 (59%)
Skin (33) (5) (48)
Acanthosis 1 (3%)
Ulcer 1 (3%) 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic
Active 1 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05073-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TECHNICAL GRADE PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 05:28:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 100 PPM 200 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (33) (4) (49)
Compression 2 (4%)
Meninges, Infiltration Cellular, Lymphocyte 2 (6%) 3 (6%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (35) (5) (50)
Hyperplasia, Lymphoid 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%)
Perivascular, Infiltration Cellular,
Lymphocyte 1 (2%)
Nose (35) (4) (49)
Lumen, Foreign Body 1 (3%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (32) (4) (49)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (33) (7) (49)
Hyperplasia, Lymphoid 2 (4%)
Inflammation, Chronic Active, Multifocal 1 (14%)
Metaplasia, Osseous 2 (4%)
Nephropathy, Chronic 13 (39%) 13 (27%)
Glomerulus, Amyloid Deposition 1 (3%)
Renal Tubule, Cytoplasmic Alteration, Diffuse 1 (14%) 1 (2%)
Renal Tubule, Necrosis, Acute 1 (2%)
Urinary Bladder (32) (3) (47)
Hyperplasia, Lymphoid 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05073-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TECHNICAL GRADE PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 05:28:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 100 PPM 200 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 35 50 50
Early Deaths
Natural Death 18 14 21
Moribund Sacrifice 5 12 3
Drowned 4
Survivors
Terminal Sacrifice 12 24 22
Animals Examined Microscopically 35 49 49
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (27) (15) (41)
Parasite Metazoan 1 (4%) 1 (7%) 1 (2%)
Intestine Small, Duodenum (24) (12) (38)
Ulcer 1 (4%)
Liver (32) (47) (48)
Angiectasis 1 (2%) 2 (4%)
Basophilic Focus 2 (6%) 1 (2%) 4 (8%)
Clear Cell Focus 4 (9%) 6 (13%)
Clear Cell Focus, Multiple 7 (15%)
Fibrosis 1 (3%)
Hematopoietic Cell Proliferation, Multifocal 2 (6%) 20 (43%) 27 (56%)
Hyperplasia 6 (13%) 5 (10%)
Infarct 1 (3%) 2 (4%) 1 (2%)
Inflammation, Chronic Active, Diffuse 42 (89%) 46 (96%)
Pigmentation, Multifocal 45 (96%) 46 (96%)
Vacuolization Cytoplasmic 2 (4%)
Bile Duct, Cyst, Multiple 1 (2%)
Bile Duct, Dilatation, Focal 1 (2%)
Bile Duct, Hyperplasia, Multifocal 22 (47%) 37 (77%)
Hepatocyte, Cytomegaly, Diffuse 47 (100%) 48 (100%)
Hepatocyte, Necrosis, Acute, Diffuse 41 (87%) 45 (94%)
Mesentery (2) (2)
Inflammation, Chronic 1 (50%) 1 (50%)
Salivary Glands (32) (15) (48)
Inflammation, Acute 1 (3%)
Inflammation, Chronic Active 1 (2%)
Stomach, Forestomach (31) (14) (43)
Acanthosis 2 (5%)
Cyst 1 (3%)
Inflammation, Chronic Active 2 (5%)
Ulcer, Chronic Active 1 (2%)
Stomach, Glandular (31) (14) (42)
Hyperplasia 1 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05073-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TECHNICAL GRADE PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 05:28:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 100 PPM 200 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Necrosis 1 (3%)
Ulcer, Acute 1 (2%)
Tooth (1) (3)
Peridontal Tissue, Inflammation, Chronic 3 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (33) (18) (49)
Degeneration, Chronic 2 (6%) 1 (6%) 2 (4%)
Mineralization 1 (6%) 1 (2%)
Atrium, Thrombosis 2 (11%) 3 (6%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (31) (47) (46)
Capsule, Hyperplasia 27 (87%) 33 (70%) 27 (59%)
Adrenal Gland, Cortex (31) (46) (46)
Degeneration, Fatty 2 (4%)
Hyperplasia 4 (9%)
Hypertrophy 5 (16%) 10 (22%) 6 (13%)
Adrenal Gland, Medulla (31) (45) (45)
Hyperplasia 1 (3%) 10 (22%) 10 (22%)
Pituitary Gland (29) (12) (41)
Pars Distalis, Cyst 1 (3%) 1 (8%)
Thyroid Gland (31) (15) (47)
Follicle, Cyst 1 (2%)
Follicular Cell, Hyperplasia 3 (10%)
Follicular Cell, Hypertrophy 1 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Inflammation, Focal, Granulomatous 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (34) (17) (47)
Granuloma Sperm 1 (6%)
Inflammation, Acute 1 (3%)
Inflammation, Chronic Active 1 (2%)
Penis (2) (5)
Inflammation, Acute 1 (20%)
Inflammation, Chronic Active 1 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05073-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TECHNICAL GRADE PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 05:28:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 100 PPM 200 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Preputial Gland (6) (6) (8)
Inflammation, Acute 6 (75%)
Inflammation, Chronic Active 3 (50%) 4 (67%)
Duct, Dilatation 2 (33%) 1 (13%)
Prostate (34) (15) (45)
Inflammation, Acute 6 (18%) 1 (7%) 1 (2%)
Inflammation, Chronic Active 3 (9%) 4 (27%) 3 (7%)
Seminal Vesicle (7) (4) (7)
Dilatation 5 (71%) 3 (75%) 6 (86%)
Inflammation, Acute 1 (14%)
Inflammation, Chronic Active 2 (29%) 1 (25%) 1 (14%)
Testes (34) (17) (47)
Inflammation, Acute 1 (3%)
Necrosis 1 (2%)
Germinal Epithelium, Degeneration 1 (3%) 3 (18%) 3 (6%)
Germinal Epithelium, Mineralization 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (2) (1)
Neutrophilia 1 (50%) 1 (100%)
Bone Marrow (30) (15) (44)
Femoral, Hyperplasia, Neutrophil 2 (7%) 2 (13%) 3 (7%)
Lymph Node (27) (24) (44)
Inguinal, Infiltration Cellular, Plasma Cell 1 (2%)
Lumbar, Hyperplasia, Plasma Cell 1 (4%)
Mesenteric, Hematopoietic Cell Proliferation 5 (19%) 10 (42%) 10 (23%)
Mesenteric, Hyperplasia, Lymphoid 1 (2%)
Renal, Hyperplasia, Plasma Cell 1 (4%)
Lymph Node, Mandibular (27) (12) (43)
Depletion Lymphoid 1 (4%) 2 (5%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Lymphoid 4 (9%)
Hyperplasia, Plasma Cell 1 (4%)
Spleen (30) (23) (46)
Depletion Lymphoid 8 (27%) 3 (13%) 10 (22%)
Lymphoid Follicle, Necrosis 2 (7%)
Red Pulp, Hematopoietic Cell Proliferation,
Diffuse 5 (17%) 15 (65%) 18 (39%)
Thymus (16) (7) (18)
Necrosis 1 (6%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05073-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TECHNICAL GRADE PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 05:28:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 100 PPM 200 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (33) (27) (49)
Acanthosis 1 (3%) 1 (4%)
Alopecia 2 (7%)
Cyst Epithelial Inclusion 1 (2%)
Foreign Body, Focal 1 (2%)
Hyperkeratosis 1 (4%)
Ulcer 3 (9%) 5 (19%) 6 (12%)
Subcutaneous Tissue, Fibrosis 4 (15%)
Subcutaneous Tissue, Inflammation, Acute 1 (3%)
Subcutaneous Tissue, Inflammation, Chronic
Active 5 (15%) 6 (12%)
Subcutaneous Tissue, Metaplasia, Osseous 1 (3%)
Subcutaneous Tissue, Lymphatic, Dilatation 1 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (35) (28) (48)
Joint, Femur, Tibia, Hyperostosis 1 (4%) 3 (6%)
Joint, Tarsal, Hyperostosis 11 (31%) 13 (46%) 9 (19%)
Skeletal Muscle (1)
Mineralization, Multifocal 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (33) (18) (49)
Hemorrhage, Acute 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%)
Alveolus, Foreign Body 4 (8%)
Interstitium, Inflammation, Acute 1 (6%)
Interstitium, Inflammation, Chronic Active,
Multifocal 1 (2%)
Interstitium, Mineralization 1 (6%)
Perivascular, Edema, Acute 4 (8%)
Perivascular, Edema, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05073-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TECHNICAL GRADE PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 05:28:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 100 PPM 200 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1)
Atrophy, Diffuse 1 (50%) 1 (100%)
Lens, Cataract 1 (50%)
Retina, Atrophy 1 (50%)
Harderian Gland (29) (12) (43)
Hyperplasia, Cystic 1 (3%)
Acinus, Dilatation 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (33) (18) (47)
Infiltration Cellular, Plasma Cell 1 (2%)
Inflammation, Acute 2 (6%) 1 (6%) 4 (9%)
Inflammation, Chronic Active 1 (3%) 2 (11%) 1 (2%)
Metaplasia, Osseous 1 (3%)
Nephropathy, Chronic 11 (33%) 3 (17%) 22 (47%)
Cortex, Cyst 1 (2%)
Pelvis, Inflammation, Acute 1 (3%) 3 (17%)
Pelvis, Inflammation, Chronic Active 1 (3%)
Renal Tubule, Dilatation 2 (6%)
Renal Tubule, Mineralization 1 (6%) 1 (2%)
Renal Tubule, Necrosis 1 (3%)
Urethra (6) (2)
Calculus Micro Observation Only 2 (33%) 1 (50%)
Concretion 2 (33%)
Inflammation, Acute 2 (33%) 1 (50%)
Inflammation, Chronic Active 1 (17%)
Urinary Bladder (34) (15) (43)
Calculus Gross Observation 1 (2%)
Calculus Micro Observation Only 1 (3%)
Concretion 1 (3%)
Dilatation 6 (18%) 3 (20%) 2 (5%)
Inflammation, Acute 5 (15%) 1 (7%)
Inflammation, Chronic Active 1 (3%) 2 (13%) 2 (5%)
Necrosis 1 (3%)
Mucosa, Hyperplasia 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
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