TR 349 Mouse Pathology Tables
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
Facility: Battelle Columbus Laboratory
Chemical CAS #: 87-86-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 3| 2| 3| 2| 5| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 2| 7| 2| 3| 3|
| 0| 9| 0| 0| 9| 0| 9| 3| 1| 0| 1| 9| 5| 1| 1| 9| 1| 0| 1| 0| 9| 4| 9| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + A + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A M + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X X |
Lymphoma Malignant Lymphocytic | X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Mesentery | + + |
Lymphoma Malignant Lymphocytic | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + A + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + A + + + + + + + + + + + +|
Squamous Cell Papilloma | X X X |
Squamous Cell Papilloma, Multiple | X|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + A + + + + + + + + + + + +|
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 3| 2| 3| 2| 5| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 2| 7| 2| 3| 3|
| 0| 9| 0| 0| 9| 0| 9| 3| 1| 0| 1| 9| 5| 1| 1| 9| 1| 0| 1| 0| 9| 4| 9| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + M + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + M + + +|
Pars Distalis, Adenoma | X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + M + + + I + + + + + + A + + + + + + + + + + + +|
Adenoma | X |
Luteoma | |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Lymphoma Malignant | |
Lymphocytic | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Lymphoma Malignant | |
Lymphocytic | X |
Inguinal, Lymphoma Malignant | |
Lymphocytic | X |
Lumbar, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Lymphoma Malignant | |
Histiocytic | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X X |
Mediastinal, Lymphoma Malignant Mixed| |
Mediastinal, Sarcoma, Metastatic, | |
Uncertain Primary Site | X |
Mesenteric, Lymphoma Malignant | |
Histiocytic | |
Mesenteric, Lymphoma Malignant | |
Lymphocytic | X X X X |
Pancreatic, Lymphoma Malignant | |
Lymphocytic | X |
Renal, Lymphoma Malignant Histiocytic| |
Renal, Lymphoma Malignant Lymphocytic| X |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 3| 2| 3| 2| 5| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 2| 7| 2| 3| 3|
| 0| 9| 0| 0| 9| 0| 9| 3| 1| 0| 1| 9| 5| 1| 1| 9| 1| 0| 1| 0| 9| 4| 9| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X X X X X X X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + M M M + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + + M + + + + + + + + + + + +|
Adenocarcinoma | X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | |
Lymphoma Malignant Lymphocytic | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + M + + + + + M + + + + + + + + + + + + + + + + +|
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + A + + + + + + + + + + + +|
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 3| 2| 3| 2| 5| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 2| 7| 2| 3| 3|
| 0| 9| 0| 0| 9| 0| 9| 3| 1| 0| 1| 9| 5| 1| 1| 9| 1| 0| 1| 0| 9| 4| 9| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X X X X X X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 1| 7| 7| | |
DAY ON TEST | 2| 3| 2| 0| 2| 3| 3| 8| 3| 3| | |
| 9| 1| 9| 5| 9| 0| 5| 3| 0| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + A M + + | 33 |
__________________________________________________________________________|____________|
Gallbladder | + + A A + + A A + + | 29 |
__________________________________________________________________________|____________|
Intestine Large | + + A + + + M + + + | 32 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + M + + + | 30 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + M + + + | 32 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + M + + + | 31 |
__________________________________________________________________________|____________|
Intestine Small | + + A + + + M + + + | 32 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + M + + + | 32 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + M + + + | 31 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + M + + + | 32 |
__________________________________________________________________________|____________|
Liver | + + A + + + A + + + | 33 |
Hepatocellular Adenoma | X | 3 |
Lymphoma Malignant Lymphocytic | | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Lymphoma Malignant Lymphocytic | X | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + A I + + M + + + | 31 |
Lymphoma Malignant Lymphocytic | | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + A + + + + M + + | 33 |
Lymphoma Malignant Lymphocytic | X X | 2 |
__________________________________________________________________________|____________|
Stomach | + + A + + + M + + + | 32 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + A + + + M + + + | 32 |
Squamous Cell Papilloma | X | 4 |
Squamous Cell Papilloma, Multiple | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + + M + + + | 32 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 35 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + M + + + | 34 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + A + + + M + + + | 33 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 1| 7| 7| | |
DAY ON TEST | 2| 3| 2| 0| 2| 3| 3| 8| 3| 3| | |
| 9| 1| 9| 5| 9| 0| 5| 3| 0| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Adenoma | | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + A + + + M + + + | 33 |
Pheochromocytoma Malignant | X | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + A I + + M + + + | 31 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M M + + | 30 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + + | 32 |
Pars Distalis, Adenoma | X X X X | 11 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + M M + + | 33 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + A + + + M + + + | 30 |
Adenoma | X | 2 |
Luteoma | X | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Uterus | + + A + + + M + + + | 33 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 35 |
Femoral, Lymphoma Malignant | | |
Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + M + + + + M + + | 33 |
Bronchial, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Inguinal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | X | 2 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | X X | 4 |
Mediastinal, Lymphoma Malignant Mixed| X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 1| 7| 7| | |
DAY ON TEST | 2| 3| 2| 0| 2| 3| 3| 8| 3| 3| | |
| 9| 1| 9| 5| 9| 0| 5| 3| 0| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Sarcoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Mesenteric, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mesenteric, Lymphoma Malignant | | |
Lymphocytic | X X X | 7 |
Pancreatic, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Renal, Lymphoma Malignant Histiocytic| X | 1 |
Renal, Lymphoma Malignant Lymphocytic| X | 2 |
Renal, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + M + + | 33 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X X X | 11 |
__________________________________________________________________________|____________|
Spleen | + + A + + + A + + + | 33 |
Lymphoma Malignant Lymphocytic | X X X X | 12 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Thymus | + + M + + + + M M + | 28 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + A + + + M M + + | 30 |
Adenocarcinoma | | 3 |
__________________________________________________________________________|____________|
Skin | + + A + + + A + + + | 33 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 35 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + A + + + A + + + | 33 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 35 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 1| 7| 7| | |
DAY ON TEST | 2| 3| 2| 0| 2| 3| 3| 8| 3| 3| | |
| 9| 1| 9| 5| 9| 0| 5| 3| 0| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Trachea | + + + + + + A M + + | 33 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + A + + + + + + + | 32 |
Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + A + + + A + + + | 33 |
Lymphoma Malignant Lymphocytic | X X X | 6 |
Lymphoma Malignant Mixed | X | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + M + + + | 32 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 35 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X X X | 12 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 2| 2| 2| 3| 2| 3| 3| 5| 3| 3| 3| 2| 3| 3|
| 9| 0| 1| 0| 1| 9| 0| 1| 5| 0| 0| 9| 9| 9| 1| 9| 0| 1| 6| 0| 1| 0| 9| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
100 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | |
__________________________________________________________________________|
Gallbladder | |
__________________________________________________________________________|
Intestine Large | |
__________________________________________________________________________|
Intestine Large, Cecum | |
__________________________________________________________________________|
Intestine Large, Colon | |
__________________________________________________________________________|
Intestine Large, Rectum | |
__________________________________________________________________________|
Intestine Small | + |
__________________________________________________________________________|
Intestine Small, Duodenum | |
__________________________________________________________________________|
Intestine Small, Ileum | + |
Peyer's Patch, Lymphoma Malignant | |
Lymphocytic | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
Peyer's Patch, Lymphoma Malignant | |
Lymphocytic | X |
Peyer's Patch, Lymphoma Malignant | |
Mixed | |
__________________________________________________________________________|
Liver | + + + + + + + + A + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic | |
Hemangiosarcoma, Multiple | X |
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X X X X X|
Hepatocellular Adenoma, Multiple | X |
Ito Cell Tumor Benign, Multiple | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Mesentery | |
Fibrosarcoma, Metastatic | |
__________________________________________________________________________|
Pancreas | + |
__________________________________________________________________________|
Salivary Glands | |
__________________________________________________________________________|
Stomach | |
__________________________________________________________________________|
Stomach, Forestomach | |
__________________________________________________________________________|
Stomach, Glandular | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + A + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | |
__________________________________________________________________________|
Parathyroid Gland | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 2| 2| 2| 3| 2| 3| 3| 5| 3| 3| 3| 2| 3| 3|
| 9| 0| 1| 0| 1| 9| 0| 1| 5| 0| 0| 9| 9| 9| 1| 9| 0| 1| 6| 0| 1| 0| 9| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
100 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + I + + + + |
Adenoma | X |
Carcinoma | |
Luteoma | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | |
__________________________________________________________________________|
Lymph Node | + + + |
Mesenteric, Lymphoma Malignant | |
Histiocytic | |
Mesenteric, Lymphoma Malignant | |
Lymphocytic | X |
Mesenteric, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | |
__________________________________________________________________________|
Spleen | + + + + |
Fibrosarcoma | X |
Hemangiosarcoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Thymus | |
Lymphoma Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + |
Adenocarcinoma | X X |
__________________________________________________________________________|
Skin | |
Subcutaneous Tissue, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 2| 2| 2| 3| 2| 3| 3| 5| 3| 3| 3| 2| 3| 3|
| 9| 0| 1| 0| 1| 9| 0| 1| 5| 0| 0| 9| 9| 9| 1| 9| 0| 1| 6| 0| 1| 0| 9| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
100 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + |
Alveolar/Bronchiolar Adenoma | X |
__________________________________________________________________________|
Nose | |
__________________________________________________________________________|
Trachea | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urinary Bladder | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| |
DAY ON TEST | 2| 2| 3| 3| 2| 3| 9| 3| 2| 8| 3| 2| 3| 2| 3| 0| 3| 2| 3| 0| 3| 5| 3| 3| 7| |
| 9| 4| 0| 0| 9| 1| 2| 1| 9| 2| 1| 9| 1| 9| 0| 5| 1| 9| 1| 7| 1| 3| 0| 0| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
100 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + +| 4 |
__________________________________________________________________________|____________|
Gallbladder | A A M A| |
__________________________________________________________________________|____________|
Intestine Large | A + + +| 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + A| 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + +| 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + M +| 2 |
__________________________________________________________________________|____________|
Intestine Small | A + + + +| 5 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + +| 3 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A A M A| 1 |
Peyer's Patch, Lymphoma Malignant | | |
Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + +| 5 |
Peyer's Patch, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Peyer's Patch, Lymphoma Malignant | | |
Mixed | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosarcoma, Metastatic | X | 1 |
Hemangiosarcoma, Multiple | X | 2 |
Hepatocellular Carcinoma | X | 1 |
Hepatocellular Adenoma | X X | 7 |
Hepatocellular Adenoma, Multiple | | 1 |
Ito Cell Tumor Benign, Multiple | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fibrosarcoma, Metastatic | X | 1 |
__________________________________________________________________________|____________|
Pancreas | A + + +| 4 |
__________________________________________________________________________|____________|
Salivary Glands | + + + +| 4 |
__________________________________________________________________________|____________|
Stomach | A + + +| 3 |
__________________________________________________________________________|____________|
Stomach, Forestomach | A + + +| 3 |
__________________________________________________________________________|____________|
Stomach, Glandular | A + + +| 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + +| 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| |
DAY ON TEST | 2| 2| 3| 3| 2| 3| 9| 3| 2| 8| 3| 2| 3| 2| 3| 0| 3| 2| 3| 0| 3| 5| 3| 3| 7| |
| 9| 4| 0| 0| 9| 1| 2| 1| 9| 2| 1| 9| 1| 9| 0| 5| 1| 9| 1| 7| 1| 3| 0| 0| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
100 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
Pheochromocytoma Benign | | 1 |
Bilateral, Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | A + + +| 3 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + +| 4 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + M + + +| 14 |
Pars Distalis, Adenoma | X | 8 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + +| 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + +| 23 |
Adenoma | | 1 |
Carcinoma | X | 1 |
Luteoma | X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + +| 37 |
Polyp Stromal | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + +| 4 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + +| 12 |
Mesenteric, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mesenteric, Lymphoma Malignant | | |
Lymphocytic | X X | 3 |
Mesenteric, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + +| 4 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + +| 13 |
Fibrosarcoma | | 1 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X X X X | 4 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Thymus | M + M + M| 2 |
Lymphoma Malignant Histiocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + M| 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| |
DAY ON TEST | 2| 2| 3| 3| 2| 3| 9| 3| 2| 8| 3| 2| 3| 2| 3| 0| 3| 2| 3| 0| 3| 5| 3| 3| 7| |
| 9| 4| 0| 0| 9| 1| 2| 1| 9| 2| 1| 9| 1| 9| 0| 5| 1| 9| 1| 7| 1| 3| 0| 0| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
100 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Adenocarcinoma | | 2 |
__________________________________________________________________________|____________|
Skin | + + + + +| 5 |
Subcutaneous Tissue, Fibrosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + +| 4 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + A + + +| 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + +| 5 |
Alveolar/Bronchiolar Adenoma | | 1 |
__________________________________________________________________________|____________|
Nose | + + + +| 4 |
__________________________________________________________________________|____________|
Trachea | + + + +| 4 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + +| 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + +| 7 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | A + + +| 3 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X X X | 6 |
Lymphoma Malignant Mixed | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 2| 1| 7| 1| 3| 3| 3| 3| 3| 9| 8| 3| 2| 9| 2| 3| 1| 2| 2| 3| 3| 9| 3|
| 4| 1| 9| 0| 3| 8| 0| 0| 1| 0| 1| 5| 2| 0| 9| 4| 9| 0| 1| 9| 9| 1| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
200 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + + + A + + + + + A A + + + + M A + + + + + +|
__________________________________________________________________________|
Intestine Large | A + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + A + + + + + + + + + M + + +|
Peyer's Patch, Lymphoma Malignant | |
Mixed | |
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hemangiosarcoma, Multiple | X X X |
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | |
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Pancreas | M + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | M + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | A + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | M + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M + M M + + + + + + + + + + + + + M + M M + + +|
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + M + + + + I + + + + + + M + M + M|
Pars Distalis, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 2| 1| 7| 1| 3| 3| 3| 3| 3| 9| 8| 3| 2| 9| 2| 3| 1| 2| 2| 3| 3| 9| 3|
| 4| 1| 9| 0| 3| 8| 0| 0| 1| 0| 1| 5| 2| 0| 9| 4| 9| 0| 1| 9| 9| 1| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
200 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
C-Cell, Adenoma | X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Lymphoma Malignant Histiocytic | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | A + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Malignant | X |
Hemangiosarcoma | |
Luteoma | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Uterus | A + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | A + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hemangiosarcoma | X X |
Femoral, Lymphoma Malignant | |
Histiocytic | |
__________________________________________________________________________|
Lymph Node | + + + M + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Lymphoma Malignant | |
Histiocytic | X |
Inguinal, Lymphoma Malignant Mixed | |
Lumbar, Lymphoma Malignant | |
Lymphocytic | |
Lumbar, Lymphoma Malignant Mixed | |
Mediastinal, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
Mediastinal, Lymphoma Malignant | |
Histiocytic | X |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Lymphoma Malignant Mixed| X |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 2| 1| 7| 1| 3| 3| 3| 3| 3| 9| 8| 3| 2| 9| 2| 3| 1| 2| 2| 3| 3| 9| 3|
| 4| 1| 9| 0| 3| 8| 0| 0| 1| 0| 1| 5| 2| 0| 9| 4| 9| 0| 1| 9| 9| 1| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
200 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mesenteric, Lymphoma Malignant | |
Histiocytic | X |
Mesenteric, Lymphoma Malignant | |
Lymphocytic | X |
Mesenteric, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Lymphocytic| |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + M + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | A + + + + A + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | M M + M M M + + + + + M M + + + M M + + + + + M +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M + M M + + + + M + + M + + + + + + + + +|
Adenoacanthoma | X |
Adenocarcinoma | |
Carcinoma | |
__________________________________________________________________________|
Skin | A + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | X |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Hemangiosarcoma | X |
Subcutaneous Tissue, Lymphoma | |
Malignant Histiocytic | |
Subcutaneous Tissue, Lymphoma | |
Malignant Lymphocytic | |
Subcutaneous Tissue, Lymphoma | |
Malignant Mixed | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Vertebra, Osteosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 2| 1| 7| 1| 3| 3| 3| 3| 3| 9| 8| 3| 2| 9| 2| 3| 1| 2| 2| 3| 3| 9| 3|
| 4| 1| 9| 0| 3| 8| 0| 0| 1| 0| 1| 5| 2| 0| 9| 4| 9| 0| 1| 9| 9| 1| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
200 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | A + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Spinal Cord | |
Osteosarcoma, Metastatic, Bone | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoacanthoma, Metastatic, Mammary | |
Gland | X |
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Fibrosarcoma, Metastatic, Skin | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
Mediastinum, Lymphoma Malignant | |
Lymphocytic | |
Mediastinum, Lymphoma Malignant Mixed| |
__________________________________________________________________________|
Nose | M + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Trachea | M + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | A + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Urinary Bladder | A + + + M + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 2| 7| 6| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 2| 2| 3| 7| 2| 2| 6| 3| 3| 2| 3| 3| 2| 1| 5| 8| 3| 4| 5| 3| 2| 2| |
| 1| 1| 1| 9| 9| 0| 5| 4| 9| 1| 0| 1| 9| 0| 0| 9| 3| 6| 1| 0| 7| 8| 1| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
200 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + M + + + + + + + + + + + + + + + M + + + + + +| 47 |
__________________________________________________________________________|____________|
Gallbladder | + + A + + + + A + + + + + + + + A A + + + A + + +| 39 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + M + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + M + + + + + + + + A + + + + + + + +| 45 |
Peyer's Patch, Lymphoma Malignant | | |
Mixed | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + M + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + M + + + + + + + + A + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + M + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + M + + + + + + + + A + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + M + + + + + + + + A + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 1 |
Hemangiosarcoma, Multiple | | 3 |
Hepatocellular Carcinoma | | 1 |
Hepatocellular Adenoma | X X X | 7 |
Hepatocellular Adenoma, Multiple | X | 1 |
Lymphoma Malignant Histiocytic | X | 3 |
Lymphoma Malignant Lymphocytic | X X X X X | 5 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X| 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + M + + M + + + + + + + + + + + + + + + + + + +| 47 |
Lymphoma Malignant Lymphocytic | X X X X | 5 |
Lymphoma Malignant Mixed | X X| 2 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + M + + + + + + + + A + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + M + + + + + + + + A + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + M + + + + + + + + A + + + + + + + +| 47 |
Lymphoma Malignant Mixed | X| 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X X | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 2| 7| 6| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 2| 2| 3| 7| 2| 2| 6| 3| 3| 2| 3| 3| 2| 1| 5| 8| 3| 4| 5| 3| 2| 2| |
| 1| 1| 1| 9| 9| 0| 5| 4| 9| 1| 0| 1| 9| 0| 0| 9| 3| 6| 1| 0| 7| 8| 1| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
200 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + M + + M + M + + M + + M M + + + + M + + +| 35 |
__________________________________________________________________________|____________|
Pituitary Gland | M M + + + + + + M M + + + + + + + + + + M + + + +| 39 |
Pars Distalis, Adenoma | X X| 5 |
Pars Distalis, Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Lymphocytic | X | 1 |
C-Cell, Adenoma | | 1 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Granulosa Cell Tumor Malignant | | 1 |
Hemangiosarcoma | X | 1 |
Luteoma | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X X X | 5 |
Lymphoma Malignant Mixed | X X X| 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant Mixed | X| 1 |
Polyp Stromal | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Femoral, Hemangiosarcoma | | 2 |
Femoral, Lymphoma Malignant | | |
Histiocytic | X X | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + M + + M + M + + + + + + + + + + + + + + + + +| 46 |
Bronchial, Lymphoma Malignant | | |
Histiocytic | | 1 |
Inguinal, Lymphoma Malignant Mixed | X| 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 2| 7| 6| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 2| 2| 3| 7| 2| 2| 6| 3| 3| 2| 3| 3| 2| 1| 5| 8| 3| 4| 5| 3| 2| 2| |
| 1| 1| 1| 9| 9| 0| 5| 4| 9| 1| 0| 1| 9| 0| 0| 9| 3| 6| 1| 0| 7| 8| 1| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
200 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Lumbar, Lymphoma Malignant Mixed | X | 1 |
Mediastinal, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | X | 2 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | X X | 3 |
Mediastinal, Lymphoma Malignant Mixed| X X| 3 |
Mesenteric, Lymphoma Malignant | | |
Histiocytic | X | 2 |
Mesenteric, Lymphoma Malignant | | |
Lymphocytic | X X X | 4 |
Mesenteric, Lymphoma Malignant Mixed | X | 2 |
Renal, Lymphoma Malignant Lymphocytic| X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + M + M + + + + + + + + + + + + + + + + +| 45 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X X X X X | 8 |
Lymphoma Malignant Mixed | X X X| 4 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + A + + + + + + + + + + + + + + + + +| 47 |
Hemangiosarcoma | | 3 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X X X X X | 6 |
Lymphoma Malignant Mixed | X X X | 4 |
__________________________________________________________________________|____________|
Thymus | + M M + + M + M + + + + + M + + + M M + + + + + +| 33 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + M + M + + M + M + M + + + + + + + M| 34 |
Adenoacanthoma | | 1 |
Adenocarcinoma | X | 1 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 2| 7| 6| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 2| 2| 3| 7| 2| 2| 6| 3| 3| 2| 3| 3| 2| 1| 5| 8| 3| 4| 5| 3| 2| 2| |
| 1| 1| 1| 9| 9| 0| 5| 4| 9| 1| 0| 1| 9| 0| 0| 9| 3| 6| 1| 0| 7| 8| 1| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
200 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Squamous Cell Carcinoma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | X | 2 |
Subcutaneous Tissue, Hemangiosarcoma | | 1 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Histiocytic | X X | 2 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Lymphocytic | X | 1 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Mixed | X| 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + I + + + + + + + + + + + + + + + + + + + +| 49 |
Lumbar, Vertebra, Osteosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | X X | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Osteosarcoma, Metastatic, Bone | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoacanthoma, Metastatic, Mammary | | |
Gland | | 1 |
Alveolar/Bronchiolar Adenoma | X | 2 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Fibrosarcoma, Metastatic, Skin | X | 1 |
Lymphoma Malignant Histiocytic | X X | 2 |
Lymphoma Malignant Lymphocytic | X X X X | 4 |
Lymphoma Malignant Mixed | X | 1 |
Mediastinum, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
Mediastinum, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Mediastinum, Lymphoma Malignant Mixed| X| 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 2| 7| 6| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 2| 2| 3| 7| 2| 2| 6| 3| 3| 2| 3| 3| 2| 1| 5| 8| 3| 4| 5| 3| 2| 2| |
| 1| 1| 1| 9| 9| 0| 5| 4| 9| 1| 0| 1| 9| 0| 0| 9| 3| 6| 1| 0| 7| 8| 1| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
200 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Histiocytic | X X | 2 |
Lymphoma Malignant Lymphocytic | X X X X X X | 7 |
Lymphoma Malignant Mixed | X X| 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + A + + + + + + + + + + + + + + + + +| 47 |
Lymphoma Malignant Lymphocytic | X X X X | 4 |
Lymphoma Malignant Mixed | X X| 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X X | 4 |
Lymphoma Malignant Lymphocytic | X X X X X X X | 9 |
Lymphoma Malignant Mixed | X X X X| 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 4| 1| 7| 4| 1| 6| 4| 7| 7| 3| 5| 1| 5| 7| 2| 3| 4| 2| 3| 7|
DAY ON TEST | 3| 3| 2| 9| 2| 2| 8| 3| 2| 2| 7| 1| 3| 3| 3| 9| 0| 5| 3| 8| 6| 7| 6| 4| 3|
| 1| 1| 9| 8| 9| 7| 7| 1| 6| 6| 9| 7| 0| 0| 0| 8| 2| 2| 0| 6| 3| 5| 5| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + A + + + + + + M M +|
__________________________________________________________________________|
Gallbladder | + + + A + + M + + A A A + + + A A A + A + + A M +|
__________________________________________________________________________|
Intestine Large | + + + + + + A + + + + + + + + A + A + A + + A A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + M A + + A + + + + + A M A + A + + A A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + A A A + A + + A A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + A + + + + + A M A + A + + A A +|
__________________________________________________________________________|
Intestine Small | + + + + + + A + + A + + + + + A + A + A + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + M A + + A + + + + + A A A + A + + A M +|
Polyp Adenomatous | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + M A + + A + + + + M A M A + A + + A A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + A + + + + + A M A + A + + A A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + A + + + + + + A M +|
Hepatocellular Carcinoma | |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | + |
Fibrosarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Pancreas | + + + + + + A + + + + + + + + A M A + A + + M M +|
Fibrosarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + A + + + + + + M M +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + A + A + A + + + M +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + A + A + A + + + M +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + A + A + A + + + M +|
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + A + + + + + + + M +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + A A A + + + + + M +|
Capsule, Fibrosarcoma, Metastatic, | |
Skin | |
Capsule, Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + A A A + + + + + M +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + A A A + + + + + M +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + A + + + + + + + + A M A + A + + A M +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + I M + + + M + A M M + + M + M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + A A M + M + + M M +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + M + + + + + A + + + + + + M M +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 4| 1| 7| 4| 1| 6| 4| 7| 7| 3| 5| 1| 5| 7| 2| 3| 4| 2| 3| 7|
DAY ON TEST | 3| 3| 2| 9| 2| 2| 8| 3| 2| 2| 7| 1| 3| 3| 3| 9| 0| 5| 3| 8| 6| 7| 6| 4| 3|
| 1| 1| 9| 8| 9| 7| 7| 1| 6| 6| 9| 7| 0| 0| 0| 8| 2| 2| 0| 6| 3| 5| 5| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Penis | + + |
__________________________________________________________________________|
Preputial Gland | + + + + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + A + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + A + A + A + + + A +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + M + + + + + A M A + A + + M M +|
Axillary, Inguinal, Fibrosarcoma, | |
Metastatic, Skin | |
Mesenteric, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + A M A + A + + M M +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + A M A + + + + A M +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + + + M + + M M + + M + M M + M M M + M M + M M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + A A +|
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Fibrosarcoma, | |
Multiple | |
Subcutaneous Tissue, Mast Cell Tumor | |
Benign | |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + A A A + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + A + + + + + + + M +|
Alveolar/Bronchiolar Adenoma | X X|
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Sarcoma, Metastatic, Skin | |
Sarcoma, Metastatic, Tooth | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + M + + + + + A + + + + + + M M +|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 4| 1| 7| 4| 1| 6| 4| 7| 7| 3| 5| 1| 5| 7| 2| 3| 4| 2| 3| 7|
DAY ON TEST | 3| 3| 2| 9| 2| 2| 8| 3| 2| 2| 7| 1| 3| 3| 3| 9| 0| 5| 3| 8| 6| 7| 6| 4| 3|
| 1| 1| 9| 8| 9| 7| 7| 1| 6| 6| 9| 7| 0| 0| 0| 8| 2| 2| 0| 6| 3| 5| 5| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + + + M M + + + + + + + + A + + + + + + M A +|
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + A + + + + + + + A +|
Fibrosarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Urethra | + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hemangioma | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 5| 4| 5| 6| 6| 7| | |
DAY ON TEST | 4| 7| 3| 3| 4| 2| 1| 0| 7| 3| | |
| 4| 8| 1| 1| 2| 7| 0| 4| 5| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 32 |
__________________________________________________________________________|____________|
Gallbladder | + + + M + A A A + + | 20 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 29 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A A + + + | 24 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + M + + + | 27 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A M + + + | 25 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 29 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A A + + + | 24 |
Polyp Adenomatous | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A M + + + | 23 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + | 26 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 32 |
Hepatocellular Carcinoma | X | 1 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | X | 5 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fibrosarcoma, Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + A + + + | 27 |
Fibrosarcoma, Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 32 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 31 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 31 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 31 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Peridontal Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 33 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 31 |
Capsule, Fibrosarcoma, Metastatic, | | |
Skin | X | 1 |
Capsule, Sarcoma, Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 31 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 31 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + A + + + | 27 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + M + + + + | 24 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 5| 4| 5| 6| 6| 7| | |
DAY ON TEST | 4| 7| 3| 3| 4| 2| 1| 0| 7| 3| | |
| 4| 8| 1| 1| 2| 7| 0| 4| 5| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 29 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 31 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Penis | | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + | 6 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 7 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 34 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + | 2 |
__________________________________________________________________________|____________|
Bone Marrow | A + + + + + + + + + | 30 |
__________________________________________________________________________|____________|
Lymph Node | + M + + + + + + + + | 27 |
Axillary, Inguinal, Fibrosarcoma, | | |
Metastatic, Skin | X | 1 |
Mesenteric, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + | 27 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 30 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Thymus | + M + M + M M M + | 16 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 33 |
Subcutaneous Tissue, Fibrosarcoma | X | 1 |
Subcutaneous Tissue, Fibrosarcoma, | | |
Multiple | X | 1 |
Subcutaneous Tissue, Mast Cell Tumor | | |
Benign | X | 1 |
Subcutaneous Tissue, Sarcoma | X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 35 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 5| 4| 5| 6| 6| 7| | |
DAY ON TEST | 4| 7| 3| 3| 4| 2| 1| 0| 7| 3| | |
| 4| 8| 1| 1| 2| 7| 0| 4| 5| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + A + + + | 31 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 33 |
Alveolar/Bronchiolar Adenoma | | 2 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Sarcoma, Metastatic, Skin | X | 1 |
Sarcoma, Metastatic, Tooth | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 31 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + M + + + + + | 29 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 33 |
Fibrosarcoma, Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Urethra | + | 6 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 34 |
Hemangioma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 35 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 3| 5| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 3| 5| 3|
DAY ON TEST | 3| 2| 2| 2| 5| 8| 3| 0| 5| 3| 3| 2| 0| 2| 6| 3| 3| 3| 3| 3| 3| 2| 1| 7| 4|
| 6| 9| 9| 8| 0| 7| 1| 5| 6| 0| 8| 9| 8| 9| 4| 0| 1| 1| 0| 1| 0| 1| 5| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A A + + + A A + A|
__________________________________________________________________________|
Intestine Large | A + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | A A + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | A A M + + + A + +|
__________________________________________________________________________|
Intestine Small | A A + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A A + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | A A + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A A + + + + A + +|
__________________________________________________________________________|
Liver | + + A + + + + + + + + + + + + + + + + + + A + +|
Cholangiocarcinoma | X |
Hemangiosarcoma | |
Hemangiosarcoma, Multiple | X |
Hepatocellular Carcinoma | X X X X X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X X X X X |
Hepatocellular Adenoma, Multiple | X X |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Pancreas | A + + + + + A + +|
__________________________________________________________________________|
Salivary Glands | A + + + + + A + +|
__________________________________________________________________________|
Stomach | A + + + + + A + +|
__________________________________________________________________________|
Stomach, Forestomach | A + + + + + A + +|
__________________________________________________________________________|
Stomach, Glandular | A + + + + + A + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + A + + + + + + + + + + + + + + + + + + A + +|
Capsule, Adenoma | X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + A + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + A + + + + + + + + + + + + + + + + + + A + +|
Pheochromocytoma Benign | X X X X |
Bilateral, Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | A + + + + + A + +|
__________________________________________________________________________|
Parathyroid Gland | A + + + + + M + M|
__________________________________________________________________________|
Pituitary Gland | M + + + + + A + +|
__________________________________________________________________________|
Thyroid Gland | A + + + + + M + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 3| 5| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 3| 5| 3|
DAY ON TEST | 3| 2| 2| 2| 5| 8| 3| 0| 5| 3| 3| 2| 0| 2| 6| 3| 3| 3| 3| 3| 3| 2| 1| 7| 4|
| 6| 9| 9| 8| 0| 7| 1| 5| 6| 0| 8| 9| 8| 9| 4| 0| 1| 1| 0| 1| 0| 1| 5| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + A + +|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + |
Carcinoma | |
__________________________________________________________________________|
Prostate | A + + + + + A + +|
__________________________________________________________________________|
Seminal Vesicle | + + +|
__________________________________________________________________________|
Testes | + + + + + + A + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | A + + + + + A + +|
__________________________________________________________________________|
Lymph Node | A M + + + + + + + + M + +|
Lumbar, Lymphoma Malignant | |
Histiocytic | |
Mediastinal, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
Mediastinal, Lymphoma Malignant | |
Histiocytic | |
Mesenteric, Lymphoma Malignant | |
Histiocytic | |
Mesenteric, Lymphoma Malignant Mixed | |
Pancreatic, Lymphoma Malignant | |
Histiocytic | |
__________________________________________________________________________|
Lymph Node, Mandibular | A M + + + + M + +|
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Spleen | + A + + + + + + + M + +|
__________________________________________________________________________|
Thymus | M + + M M M A + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M|
__________________________________________________________________________|
Skin | + A + + + + + + + + + + + I|
Basosquamous Tumor Malignant | |
Carcinoma | X |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | X X X X X |
Subcutaneous Tissue, Fibrosarcoma, | |
Multiple | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | A + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 3| 5| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 3| 5| 3|
DAY ON TEST | 3| 2| 2| 2| 5| 8| 3| 0| 5| 3| 3| 2| 0| 2| 6| 3| 3| 3| 3| 3| 3| 2| 1| 7| 4|
| 6| 9| 9| 8| 0| 7| 1| 5| 6| 0| 8| 9| 8| 9| 4| 0| 1| 1| 0| 1| 0| 1| 5| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Fibrosarcoma, Metastatic, Skin | X |
__________________________________________________________________________|
Nose | + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | M + M + + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | A + + + + + + + + +|
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | A + + + + + A + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
__________________________________________________________________________________________________________________________________
| 4| 6| 4| 7| 6| 7| 7| 7| 7| 6| 5| 7| 5| 7| 6| 7| 6| 3| 1| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 1| 8| 9| 0| 8| 3| 2| 2| 3| 2| 4| 3| 4| 3| 3| 3| 5| 3| 8| 3| 3| 2| 2| 9| 2| |
| 3| 9| 2| 4| 2| 1| 9| 9| 1| 6| 5| 0| 3| 1| 5| 1| 6| 6| 9| 1| 0| 9| 9| 3| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| A |
100 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Gallbladder | + A + + A A + A | 8 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + A | 12 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + A | 12 |
__________________________________________________________________________|____________|
Intestine Small | + + + + A + + + | 13 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + A | 12 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + | 13 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + | 13 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Cholangiocarcinoma | | 1 |
Hemangiosarcoma | X | 1 |
Hemangiosarcoma, Multiple | | 1 |
Hepatocellular Carcinoma | X X X | 9 |
Hepatocellular Carcinoma, Multiple | X | 1 |
Hepatocellular Adenoma | X X X X X | 12 |
Hepatocellular Adenoma, Multiple | X X X X X X | 8 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Stomach | + + + + A + + + | 14 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + A + + + | 14 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + | 14 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 18 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Capsule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + I + + + + + + + + + + + + + + +| 45 |
Pheochromocytoma Benign | | 4 |
Bilateral, Pheochromocytoma Benign | X X X X | 6 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + M + + | 12 |
__________________________________________________________________________|____________|
Pituitary Gland | + I + + M + + M | 12 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 34
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
__________________________________________________________________________________________________________________________________
| 4| 6| 4| 7| 6| 7| 7| 7| 7| 6| 5| 7| 5| 7| 6| 7| 6| 3| 1| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 1| 8| 9| 0| 8| 3| 2| 2| 3| 2| 4| 3| 4| 3| 3| 3| 5| 3| 8| 3| 3| 2| 2| 9| 2| |
| 3| 9| 2| 4| 2| 1| 9| 9| 1| 6| 5| 0| 3| 1| 5| 1| 6| 6| 9| 1| 0| 9| 9| 3| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| A |
100 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Penis | + + + + | 5 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 6 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Seminal Vesicle | + | 4 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + | 17 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + +| 24 |
Lumbar, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mediastinal, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | X | 1 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mesenteric, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mesenteric, Lymphoma Malignant Mixed | X | 1 |
Pancreatic, Lymphoma Malignant | | |
Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 12 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Thymus | + M I + M I + + | 7 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 27 |
Basosquamous Tumor Malignant | X | 1 |
Carcinoma | | 1 |
Subcutaneous Tissue, Fibroma | X | 2 |
Subcutaneous Tissue, Fibrosarcoma | X X X X | 9 |
Subcutaneous Tissue, Fibrosarcoma, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
__________________________________________________________________________________________________________________________________
| 4| 6| 4| 7| 6| 7| 7| 7| 7| 6| 5| 7| 5| 7| 6| 7| 6| 3| 1| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 1| 8| 9| 0| 8| 3| 2| 2| 3| 2| 4| 3| 4| 3| 3| 3| 5| 3| 8| 3| 3| 2| 2| 9| 2| |
| 3| 9| 2| 4| 2| 1| 9| 9| 1| 6| 5| 0| 3| 1| 5| 1| 6| 6| 9| 1| 0| 9| 9| 3| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| A |
100 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Multiple | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + I + + + + + + + | 28 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 16 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 18 |
Alveolar/Bronchiolar Adenoma | | 1 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Fibrosarcoma, Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 17 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + M M | 12 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Urethra | + + | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + A + | 15 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 36
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 5| 4| 6| 7| 5| 5| 7| 1| 7| 5| 3| 2| 3| 3| 3| 5| 7| 7| 7| 7|
DAY ON TEST | 1| 2| 8| 9| 2| 2| 9| 5| 0| 8| 8| 3| 4| 3| 7| 7| 9| 7| 7| 7| 4| 3| 3| 3| 2|
| 0| 9| 0| 0| 9| 8| 0| 6| 1| 2| 4| 1| 2| 0| 0| 6| 9| 6| 6| 6| 5| 0| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + A A + M A A + A A + + + A + A + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + A A M + M A + + M A + M + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + A + + A + + + A + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | M + + A + M A A + A A + + + M + M + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + A + + A M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + A A M + M + + M + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + A A M + A A + + + A + M + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + A A M + A A + + + A + A + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Hemangiosarcoma | |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X X X X X X X X|
Hepatocellular Adenoma, Multiple | X X X X X X X X X |
Hepatocholangiocarcinoma | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X |
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Mesentery | + + |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
__________________________________________________________________________|
Pancreas | + + + A + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + A + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + M A + + + + + + + + + A + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + A A + + + + + + + + A + + + + A + + +|
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + A + + + + + M + + + + + + + + + + + +|
Pheochromocytoma Benign | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 5| 4| 6| 7| 5| 5| 7| 1| 7| 5| 3| 2| 3| 3| 3| 5| 7| 7| 7| 7|
DAY ON TEST | 1| 2| 8| 9| 2| 2| 9| 5| 0| 8| 8| 3| 4| 3| 7| 7| 9| 7| 7| 7| 4| 3| 3| 3| 2|
| 0| 9| 0| 0| 9| 8| 0| 6| 1| 2| 4| 1| 2| 0| 0| 6| 9| 6| 6| 6| 5| 0| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Bilateral, Pheochromocytoma Benign | X X X X X X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M M + + + M + + + + M M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + M + + A + + + M + + M + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | M |
__________________________________________________________________________|
Preputial Gland | + + + + |
Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + A A + + + + + + + + + M + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Seminal Vesicle | + + + + |
__________________________________________________________________________|
Testes | + + + + + + A + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + M + + + + + + + + + M + + + + + + + +|
Axillary, Lymphoma Malignant | |
Histiocytic | |
Inguinal, Lymphoma Malignant | |
Histiocytic | |
Inguinal, Sarcoma, Metastatic, Skin | |
Lumbar, Lymphoma Malignant | |
Histiocytic | |
Mediastinal, Lymphoma Malignant Mixed| X |
Mesenteric, Lymphoma Malignant | |
Histiocytic | |
Mesenteric, Lymphoma Malignant | |
Lymphocytic | |
Mesenteric, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Histiocytic| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + M + + + + + + + + + M + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + A + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 5| 4| 6| 7| 5| 5| 7| 1| 7| 5| 3| 2| 3| 3| 3| 5| 7| 7| 7| 7|
DAY ON TEST | 1| 2| 8| 9| 2| 2| 9| 5| 0| 8| 8| 3| 4| 3| 7| 7| 9| 7| 7| 7| 4| 3| 3| 3| 2|
| 0| 9| 0| 0| 9| 8| 0| 6| 1| 2| 4| 1| 2| 0| 0| 6| 9| 6| 6| 6| 5| 0| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | M + M M + M M M M M M M M M M + M + + + M + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, | |
Hepatocholangiocarcinoma, | |
Metastatic, Liver | X |
Subcutaneous Tissue, Sarcoma | X X X|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X|
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Mixed | X |
Sarcoma, Metastatic, Skin | X |
Mediastinum, | |
Hepatocholangiocarcinoma, | |
Metastatic, Liver | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + M + + + M + + + M + + + +|
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + A + + + + + + + + + + + + + + + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 5| 4| 6| 7| 5| 5| 7| 1| 7| 5| 3| 2| 3| 3| 3| 5| 7| 7| 7| 7|
DAY ON TEST | 1| 2| 8| 9| 2| 2| 9| 5| 0| 8| 8| 3| 4| 3| 7| 7| 9| 7| 7| 7| 4| 3| 3| 3| 2|
| 0| 9| 0| 0| 9| 8| 0| 6| 1| 2| 4| 1| 2| 0| 0| 6| 9| 6| 6| 6| 5| 0| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + A A + + + + + + + + + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 5| 7| 4| 6| 7| 5| 7| 7| 7| 6| 4| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 4| 2| 3| 4| 3| 9| 3| 4| 9| 3| 1| 2| 3| 2| 5| 7| 4| 1| 3| 2| 3| 2| 3| |
| 0| 0| 0| 9| 1| 9| 0| 8| 1| 6| 0| 1| 2| 9| 0| 9| 4| 6| 4| 9| 1| 9| 6| 9| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| A |
200 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + A + A A + A + + + A A + A + + + +| 32 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + A + + + + + + + + + A + A + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A + + M + A + + + + A + A + + + +| 35 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + A + A + + + +| 41 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + A + + M + M + + + + A + A + + + +| 35 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + A + + + + + + + + + A + A + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A + + + + A + + + + A + A + + + +| 38 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A + + + + M + + + + A + A + + + +| 37 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + + + + A + + + + A + A + + + +| 37 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Hemangioma | | 1 |
Hemangiosarcoma | X | 1 |
Hepatocellular Carcinoma | X X X X X X X | 11 |
Hepatocellular Carcinoma, Multiple | X | 1 |
Hepatocellular Adenoma | X X X X X | 15 |
Hepatocellular Adenoma, Multiple | X X X X X X X X X| 18 |
Hepatocholangiocarcinoma | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 2 |
Sarcoma, Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + A + + + + + + + + + A + A + + + +| 44 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + A + + + + + + + + + A + A + + + +| 44 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + A + + + + + + + + + A + A + + + +| 43 |
Squamous Cell Papilloma | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + A + + + + + + + + + A + A + + + +| 42 |
__________________________________________________________________________|____________|
Tooth | + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 41
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 5| 7| 4| 6| 7| 5| 7| 7| 7| 6| 4| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 4| 2| 3| 4| 3| 9| 3| 4| 9| 3| 1| 2| 3| 2| 5| 7| 4| 1| 3| 2| 3| 2| 3| |
| 0| 0| 0| 9| 1| 9| 0| 8| 1| 6| 0| 1| 2| 9| 0| 9| 4| 6| 4| 9| 1| 9| 6| 9| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| A |
200 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + A + + + + + + + + + + + A + + + +| 46 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + A + + + + + + + + + + + A + + + +| 46 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + A + + + + + + + + + + + A + + + +| 45 |
Pheochromocytoma Benign | X X X X | 4 |
Bilateral, Pheochromocytoma Benign | X X X X X X X X X X | 19 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + A + + + + + + + + + A + A + + + +| 44 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + M + + + +| 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + M + + + + A + + M + + + + + + + + M + + + +| 41 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + +| 47 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
__________________________________________________________________________|____________|
Penis | | |
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 8 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + A + + + +| 45 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 7 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + A + + + + + + + + + A + A + M + +| 44 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + M + + + + + + + + + M + M + + + +| 44 |
Axillary, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Inguinal, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Inguinal, Sarcoma, Metastatic, Skin | X | 1 |
Lumbar, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mediastinal, Lymphoma Malignant Mixed| | 1 |
Mesenteric, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mesenteric, Lymphoma Malignant | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 5| 7| 4| 6| 7| 5| 7| 7| 7| 6| 4| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 4| 2| 3| 4| 3| 9| 3| 4| 9| 3| 1| 2| 3| 2| 5| 7| 4| 1| 3| 2| 3| 2| 3| |
| 0| 0| 0| 9| 1| 9| 0| 8| 1| 6| 0| 1| 2| 9| 0| 9| 4| 6| 4| 9| 1| 9| 6| 9| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| A |
200 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphocytic | X | 1 |
Mesenteric, Lymphoma Malignant Mixed | X | 2 |
Renal, Lymphoma Malignant Histiocytic| X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + M + M + + + +| 43 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + A + + + + + + + + + + + A + + + +| 46 |
Hemangioma | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Thymus | + + M + M M M M + M + M + M M M M M M M + + M +| 18 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Squamous Cell Carcinoma | X | 1 |
Subcutaneous Tissue, Fibroma | X X | 3 |
Subcutaneous Tissue, Fibrosarcoma | X X| 3 |
Subcutaneous Tissue, | | |
Hepatocholangiocarcinoma, | | |
Metastatic, Liver | | 1 |
Subcutaneous Tissue, Sarcoma | X | 4 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Alveolar/Bronchiolar Adenoma | X X X | 5 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 1 |
Lymphoma Malignant Mixed | | 1 |
Sarcoma, Metastatic, Skin | X | 2 |
Mediastinum, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 05073-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:04
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 5| 7| 4| 6| 7| 5| 7| 7| 7| 6| 4| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 4| 2| 3| 4| 3| 9| 3| 4| 9| 3| 1| 2| 3| 2| 5| 7| 4| 1| 3| 2| 3| 2| 3| |
| 0| 0| 0| 9| 1| 9| 0| 8| 1| 6| 0| 1| 2| 9| 0| 9| 4| 6| 4| 9| 1| 9| 6| 9| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| A |
200 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hepatocholangiocarcinoma, | | |
Metastatic, Liver | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + M + + + + + + + + + + + + + + + A M + + +| 43 |
Adenoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + A + + + + + + + + + A + A + + + +| 43 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Histiocytic | X X | 2 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------
--multipart-boundary
Content-type: text/plain
Range: bytes 419614-419614/419614
--multipart-boundary--