TR 349 Mouse Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
TECHNICAL GRADE PENTACHLOROPHENOL
NTP Experiment-Test: 05073-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/09/94
Route: DOSED FEED Time: 05:28:16
Facility: Battelle Columbus Laboratory
Chemical CAS #: 87-86-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05073-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TECHNICAL GRADE PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 05:28:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 100 PPM 200 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 35 50 50
Early Deaths
Natural Death 6 8 13
Moribund Sacrifice 1 5
Survivors
Terminal Sacrifice 28 41 30
Natural Death 1 2
Animals Examined Microscopically 35 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (30) (2) (45)
Intestine Small, Ileum (31) (1) (45)
Intestine Small, Jejunum (32) (5) (46)
Liver (33) (49) (50)
Fibrosarcoma, Metastatic 1 (2%)
Hemangiosarcoma 1 (2%)
Hemangiosarcoma, Multiple 2 (4%) 3 (6%)
Hepatocellular Carcinoma 1 (2%) 1 (2%)
Hepatocellular Adenoma 3 (9%) 7 (14%) 7 (14%)
Hepatocellular Adenoma, Multiple 1 (2%) 1 (2%)
Ito Cell Tumor Benign, Multiple 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (3%)
Mesentery (3) (1)
Fibrosarcoma, Metastatic 1 (100%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (33%)
Pancreas (31) (4) (48)
Sarcoma, Metastatic, Uncertain Primary Site 1 (3%)
Salivary Glands (33) (4) (47)
Stomach, Forestomach (32) (3) (46)
Squamous Cell Papilloma 4 (13%)
Squamous Cell Papilloma, Multiple 1 (3%)
Stomach, Glandular (32) (3) (47)
Sarcoma, Metastatic, Uncertain Primary Site 1 (3%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (35) (4) (50)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05073-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TECHNICAL GRADE PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 05:28:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 100 PPM 200 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (33) (48) (49)
Adenoma 1 (3%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (3%)
Adrenal Gland, Medulla (33) (48) (49)
Pheochromocytoma Malignant 2 (6%)
Pheochromocytoma Benign 1 (2%) 1 (2%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Pituitary Gland (32) (14) (39)
Pars Distalis, Adenoma 11 (34%) 8 (57%) 5 (13%)
Pars Distalis, Carcinoma 1 (3%)
Thyroid Gland (33) (4) (48)
C-Cell, Adenoma 1 (2%)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
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GENITAL SYSTEM
Ovary (30) (23) (48)
Adenoma 2 (7%) 1 (4%)
Carcinoma 1 (4%)
Granulosa Cell Tumor Malignant 1 (2%)
Hemangiosarcoma 1 (2%)
Luteoma 1 (3%) 2 (9%) 1 (2%)
Uterus (33) (37) (48)
Polyp Stromal 1 (3%) 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (3%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (35) (4) (49)
Femoral, Hemangiosarcoma 2 (4%)
Lymph Node (33) (12) (46)
Mediastinal, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Mediastinal, Sarcoma, Metastatic, Uncertain
Primary Site 1 (3%)
Lymph Node, Mandibular (33) (4) (45)
Hemangiosarcoma 1 (2%)
Spleen (33) (13) (47)
Fibrosarcoma 1 (8%)
Page 3
NTP Experiment-Test: 05073-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TECHNICAL GRADE PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 05:28:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 100 PPM 200 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Hemangiosarcoma 1 (8%) 3 (6%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (3%)
Thymus (28) (2) (33)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (30) (3) (34)
Adenoacanthoma 1 (3%)
Adenocarcinoma 3 (10%) 2 (67%) 1 (3%)
Carcinoma 1 (3%)
Skin (33) (5) (48)
Squamous Cell Carcinoma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (20%) 2 (4%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (35) (4) (49)
Lumbar, Vertebra, Osteosarcoma 1 (2%)
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NERVOUS SYSTEM
Brain (33) (4) (49)
Spinal Cord (1)
Osteosarcoma, Metastatic, Bone 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (35) (5) (50)
Adenoacanthoma, Metastatic, Mammary Gland 1 (2%)
Alveolar/Bronchiolar Adenoma 1 (20%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (3%) 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (3%)
Mediastinum, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Nose (35) (4) (49)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05073-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TECHNICAL GRADE PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 05:28:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 100 PPM 200 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (32) (4) (49)
Adenoma 2 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (33) (7) (49)
Sarcoma, Metastatic, Uncertain Primary Site 1 (3%)
Urinary Bladder (32) (3) (47)
Sarcoma, Metastatic, Uncertain Primary Site 1 (3%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(35) *(50) *(50)
Lymphoma Malignant Histiocytic 1 (3%) 1 (2%) 4 (8%)
Lymphoma Malignant Lymphocytic 12 (34%) 6 (12%) 9 (18%)
Lymphoma Malignant Mixed 1 (3%) 2 (4%) 5 (10%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05073-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TECHNICAL GRADE PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 05:28:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 100 PPM 200 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 27 30 37
Total Primary Neoplasms 45 42 62
Total Animals with Benign Neoplasms 17 17 19
Total Benign Neoplasms 25 24 21
Total Animals with Malignant Neoplasms 18 17 30
Total Malignant Neoplasms 20 18 41
Total Animals with Metastatic Neoplasms 1 1 4
Total Metastatic Neoplasm 11 2 6
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05073-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TECHNICAL GRADE PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 05:28:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 100 PPM 200 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 35 50 50
Early Deaths
Natural Death 18 14 21
Moribund Sacrifice 5 12 3
Drowned 4
Survivors
Terminal Sacrifice 12 24 22
Animals Examined Microscopically 35 49 49
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (20) (8) (32)
Intestine Small, Duodenum (24) (12) (38)
Polyp Adenomatous 1 (4%)
Intestine Small, Jejunum (26) (13) (37)
Liver (32) (47) (48)
Cholangiocarcinoma 1 (2%)
Hemangioma 1 (2%)
Hemangiosarcoma 1 (2%) 1 (2%)
Hemangiosarcoma, Multiple 1 (2%)
Hepatocellular Carcinoma 1 (3%) 9 (19%) 11 (23%)
Hepatocellular Carcinoma, Multiple 1 (3%) 1 (2%) 1 (2%)
Hepatocellular Adenoma 5 (16%) 12 (26%) 15 (31%)
Hepatocellular Adenoma, Multiple 8 (17%) 18 (38%)
Hepatocholangiocarcinoma 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%)
Mesentery (2) (2)
Fibrosarcoma, Metastatic, Skin 1 (50%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (50%)
Pancreas (27) (15) (44)
Fibrosarcoma, Metastatic, Skin 1 (4%)
Stomach, Forestomach (31) (14) (43)
Squamous Cell Papilloma 1 (2%)
Tooth (1) (3)
Peridontal Tissue, Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (33) (18) (49)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05073-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TECHNICAL GRADE PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 05:28:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 100 PPM 200 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (31) (47) (46)
Capsule, Adenoma 1 (2%)
Capsule, Fibrosarcoma, Metastatic, Skin 1 (3%)
Capsule, Sarcoma, Metastatic, Skin 1 (3%)
Adrenal Gland, Medulla (31) (45) (45)
Pheochromocytoma Benign 4 (9%) 4 (9%)
Bilateral, Pheochromocytoma Benign 6 (13%) 19 (42%)
Thyroid Gland (31) (15) (47)
Follicular Cell, Adenoma 1 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (6) (6) (8)
Carcinoma 1 (17%) 1 (13%)
Prostate (34) (15) (45)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (27) (24) (44)
Axillary, Inguinal, Fibrosarcoma, Metastatic,
Skin 1 (4%)
Inguinal, Sarcoma, Metastatic, Skin 1 (2%)
Mediastinal, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (4%)
Lymph Node, Mandibular (27) (12) (43)
Spleen (30) (23) (46)
Hemangioma 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (33) (27) (49)
Basosquamous Tumor Malignant 1 (4%)
Carcinoma 1 (4%)
Squamous Cell Carcinoma 1 (2%)
Subcutaneous Tissue, Fibroma 2 (7%) 3 (6%)
Subcutaneous Tissue, Fibrosarcoma 1 (3%) 9 (33%) 3 (6%)
Subcutaneous Tissue, Fibrosarcoma, Multiple 1 (3%) 1 (4%)
Subcutaneous Tissue,
Page 8
NTP Experiment-Test: 05073-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TECHNICAL GRADE PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 05:28:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 100 PPM 200 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Hepatocholangiocarcinoma, Metastatic,
Liver 1 (2%)
Subcutaneous Tissue, Mast Cell Tumor Benign 1 (3%)
Subcutaneous Tissue, Sarcoma 2 (6%) 4 (8%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (33) (18) (49)
Alveolar/Bronchiolar Adenoma 2 (6%) 1 (6%) 5 (10%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (6%)
Fibrosarcoma, Metastatic, Skin 1 (6%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (3%) 1 (2%)
Sarcoma, Metastatic, Skin 1 (3%) 2 (4%)
Sarcoma, Metastatic, Tooth 1 (3%)
Mediastinum, Hepatocholangiocarcinoma,
Metastatic, Liver 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (29) (12) (43)
Adenoma 1 (3%) 2 (5%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (33) (18) (47)
Fibrosarcoma, Metastatic, Skin 1 (3%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Urinary Bladder (34) (15) (43)
Page 9
NTP Experiment-Test: 05073-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TECHNICAL GRADE PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 05:28:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 100 PPM 200 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont
Hemangioma 1 (3%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(35) *(49) *(49)
Lymphoma Malignant Histiocytic 1 (2%) 2 (4%)
Lymphoma Malignant Lymphocytic 2 (4%)
Lymphoma Malignant Mixed 1 (3%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05073-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TECHNICAL GRADE PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 05:28:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 100 PPM 200 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 17 38 45
Total Primary Neoplasms 20 63 100
Total Animals with Benign Neoplasms 11 28 38
Total Benign Neoplasms 12 34 71
Total Animals with Malignant Neoplasms 8 27 26
Total Malignant Neoplasms 8 29 29
Total Animals with Metastatic Neoplasms 5 2 4
Total Metastatic Neoplasm 9 2 10
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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