TR 349 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08 LAB: Battelle Columbus TECHNICAL GRADE PENTACHLOROPHENOL DATE: 09/09/94 EXPERIMENT: 05073 TEST: 01 TIME: 05:37:16 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1 CONT: N01-ES-38068 ROUTE: DOSED FEED NTP C#: 55378 PATHOLOGIST: R. PERSING S. EUSTIS CAS: 87-86-5 ------------------------------------------------------------------------------------------------------------------------------------ REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE ALL NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08 LAB: Battelle Columbus TECHNICAL GRADE PENTACHLOROPHENOL DATE: 09/09/94 EXPERIMENT: 05073 TEST: 01 TIME: 05:37:16 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE CONT: N01-ES-38068 ROUTE: DOSED FEED NTP C#: 55378 PATHOLOGIST: R. PERSING S. EUSTIS CAS: 87-86-5 MICE(B6C3F1) ---------------------------- FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED. IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED. ---------------- Adrenal Gland Bone Marrow Brain Epididymis Gallbladder Heart Islets, Pancreatic Kidney Liver Lung Nose Ovary Pancreas Parathyroid Gland Pituitary Gland Preputial Gland Prostate Salivary Glands Spleen Testes Thymus Thyroid Gland Urinary Bladder NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08 LAB: Battelle Columbus TECHNICAL GRADE PENTACHLOROPHENOL DATE: 09/09/94 EXPERIMENT: 05073 TEST: 01 TIME: 05:37:16 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE CONT: N01-ES-38068 ROUTE: DOSED FEED NTP C#: 55378 PATHOLOGIST: R. PERSING S. EUSTIS CAS: 87-86-5 SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS IN THE ANALYSIS OF THE STUDY OF TECHNICAL GRADE PENTACHLOROPHENOL ==================================================================================================== MALE MICE ------------- ORGAN MORPHOLOGY ------- ------------ Adrenal Medulla Pheochromocytoma Benign Pheochromocytoma: Benign, Complex, Malignant, NOS Liver Hepatocellular Adenoma Hepatocellular Carcinoma Hepatocellular Carcinoma or Hepatocellular Adenoma Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma All Organs Benign Tumors Malignant Tumors Malignant and Benign Tumors ==================================================================================================== FEMALE MICE ------------- ORGAN MORPHOLOGY ------- ------------ Liver Hemangiosarcoma Lung Alveolar/Bronchiolar Adenoma Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma Pituitary Gland: Pars Distalis or Unspecified Site Adenoma Carcinoma or Adenoma Stomach, Forestomach Squamous Cell Papilloma All Organs Hemangiosarcoma Hemangiosarcoma or Hemangioma Malignant Lymphoma And Histiocytic Sarcoma Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated Cell Type Malignant Tumors Malignant and Benign Tumors ==================================================================================================== DATE: 09/09/94 EXPERIMENT: 05073 TEST: 01 PAGE 1 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 100 PPM 200 PPM | 0 PPM 100 PPM 200 PPM | | | | | |=================================================================================================================================| | | |Adrenal Medulla | | Pheochromocytoma Benign | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/31 (0%) 10/45 (22%) 23/45 (51%) | 0/33 (0%) 2/48 (4%) 1/49 (2%) | |ADJUSTED (b) | 0.0% 37.9% 84.9% | 0.0% 4.9% 3.1% | |TERMINAL (d) | 0/12 (0%) 7/23 (30%) 18/22 (82%) | 0/28 (0%) 2/41 (5%) 1/32 (3%) | |FIRST INCIDENCE (DAYS) | --- 682 549 | --- 729 (T) 729 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P<0.001 ** P=0.021 * P<0.001 ** | P=0.386 P=0.326 P=0.527 | |INCIDENTAL TUMOR | P<0.001 ** P=0.021 * P<0.001 ** | P=0.386 P=0.326 P=0.527 | |LOGISTIC REGRESSION | P<0.001 ** P=0.018 * P<0.001 ** | P=0.386 P=0.326 P=0.527 | |COCHRAN-ARMITAGE | P<0.001 ** | P=0.461 | |FISHER EXACT | P=0.003 ** P<0.001 ** | P=0.348 P=0.598 | |=================================================================================================================================| | | |Adrenal Medulla | | Pheochromocytoma Malignant | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/31 (0%) 0/45 (0%) 0/45 (0%) | 2/33 (6%) 0/48 (0%) 0/49 (0%) | |ADJUSTED (b) | 0.0% 0.0% 0.0% | 6.5% 0.0% 0.0% | |TERMINAL (d) | 0/12 (0%) 0/23 (0%) 0/22 (0%) | 1/28 (4%) 0/41 (0%) 0/32 (0%) | |FIRST INCIDENCE (DAYS) | --- --- --- | 605 --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | (e) (e) (e) | P=0.069N P=0.166N P=0.195N | |INCIDENTAL TUMOR | (e) (e) (e) | P=0.111N P=0.424N P=0.225N | |LOGISTIC REGRESSION | (e) (e) (e) | P=0.058N P=0.169N P=0.154N | |COCHRAN-ARMITAGE | (e) | P=0.056N | |FISHER EXACT | (e) (e) | P=0.163N P=0.159N | |=================================================================================================================================| DATE: 09/09/94 EXPERIMENT: 05073 TEST: 01 PAGE 2 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 100 PPM 200 PPM | 0 PPM 100 PPM 200 PPM | | | | | |=================================================================================================================================| | | |Adrenal Medulla | | Pheochromocytoma: Benign, Complex, Malignant, NOS | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/31 (0%) 10/45 (22%) 23/45 (51%) | 2/33 (6%) 2/48 (4%) 1/49 (2%) | |ADJUSTED (b) | 0.0% 37.9% 84.9% | 6.5% 4.9% 3.1% | |TERMINAL (d) | 0/12 (0%) 7/23 (30%) 18/22 (82%) | 1/28 (4%) 2/41 (5%) 1/32 (3%) | |FIRST INCIDENCE (DAYS) | --- 682 549 | 605 729 (T) 729 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P<0.001 ** P=0.021 * P<0.001 ** | P=0.331N P=0.555N P=0.436N | |INCIDENTAL TUMOR | P<0.001 ** P=0.021 * P<0.001 ** | P=0.358N P=0.632 P=0.469N | |LOGISTIC REGRESSION | P<0.001 ** P=0.018 * P<0.001 ** | P=0.263N P=0.556N P=0.364N | |COCHRAN-ARMITAGE | P<0.001 ** | P=0.258N | |FISHER EXACT | P=0.003 ** P<0.001 ** | P=0.540N P=0.354N | |=================================================================================================================================| | | |Bone Marrow | | Hemangiosarcoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/30 (0%) 0/15 (0%) 0/44 (0%) | 0/35 (0%) 0/4 (0%) 2/49 (4%) | |ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 0.0% 5.9% | |TERMINAL (d) | 0/12 (0%) 0/0 0/21 (0%) | 0/29 (0%) 0/0 0/32 (0%) | |FIRST INCIDENCE (DAYS) | --- --- --- | --- --- 710 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | (e) (e) (e) | P=0.099 (e) P=0.272 | |INCIDENTAL TUMOR | (e) (e) (e) | P=0.570 (e) P=0.795 | |LOGISTIC REGRESSION | (e) (e) (e) | P=0.186 (e) P=0.304 | |COCHRAN-ARMITAGE | (e) | P=0.190 | |FISHER EXACT | (e) (e) | (e) P=0.337 | |=================================================================================================================================| DATE: 09/09/94 EXPERIMENT: 05073 TEST: 01 PAGE 3 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 100 PPM 200 PPM | 0 PPM 100 PPM 200 PPM | | | | | |=================================================================================================================================| | | |Harderian Gland | | Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 1/35 (3%) 0/49 (0%) 2/49 (4%) | 2/35 (6%) 0/50 (0%) 1/50 (2%) | |ADJUSTED (b) | 5.6% 0.0% 9.1% | 6.9% 0.0% 3.1% | |TERMINAL (d) | 0/12 (0%) 0/24 (0%) 2/22 (9%) | 2/29 (7%) 0/41 (0%) 1/32 (3%) | |FIRST INCIDENCE (DAYS) | 552 --- 729 (T) | 729 (T) --- 729 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.513 P=0.351N P=0.714 | P=0.329N P=0.166N P=0.465N | |INCIDENTAL TUMOR | P=0.555 P=0.362N P=0.717N | P=0.329N P=0.166N P=0.465N | |LOGISTIC REGRESSION | P=0.494 P=0.460N P=0.696 | P=0.329N P=0.166N P=0.465N | |COCHRAN-ARMITAGE | P=0.446 | P=0.268N | |FISHER EXACT | P=0.417N P=0.625 | P=0.167N P=0.367N | |=================================================================================================================================| | | |Liver | | Hemangiosarcoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/32 (0%) 2/47 (4%) 1/48 (2%) | 0/33 (0%) 2/49 (4%) 4/50 (8%) | |ADJUSTED (b) | 0.0% 8.3% 4.5% | 0.0% 4.4% 11.4% | |TERMINAL (d) | 0/12 (0%) 2/24 (8%) 1/22 (5%) | 0/28 (0%) 1/41 (2%) 1/32 (3%) | |FIRST INCIDENCE (DAYS) | --- 729 (T) 729 (T) | --- 424 694 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.505 P=0.400 P=0.621 | P=0.047 * P=0.328 P=0.089 | |INCIDENTAL TUMOR | P=0.505 P=0.400 P=0.621 | P=0.220 P=0.576 P=0.360 | |LOGISTIC REGRESSION | P=0.505 P=0.400 P=0.621 | P=0.075 P=0.246 P=0.115 | |COCHRAN-ARMITAGE | P=0.464 | P=0.073 | |FISHER EXACT | P=0.351 P=0.600 | P=0.354 P=0.125 | |=================================================================================================================================| DATE: 09/09/94 EXPERIMENT: 05073 TEST: 01 PAGE 4 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 100 PPM 200 PPM | 0 PPM 100 PPM 200 PPM | | | | | |=================================================================================================================================| | | |Liver | | Hepatocellular Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 5/32 (16%) 20/47 (43%) 33/48 (69%) | 3/33 (9%) 8/49 (16%) 8/50 (16%) | |ADJUSTED (b) | 27.6% 65.2% 88.6% | 10.7% 19.5% 24.0% | |TERMINAL (d) | 2/12 (17%) 14/24 (58%) 18/22 (82%) | 3/28 (11%) 8/41 (20%) 7/32 (22%) | |FIRST INCIDENCE (DAYS) | 330 413 376 | 729 (T) 729 (T) 682 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P<0.001 ** P=0.074 P<0.001 ** | P=0.113 P=0.261 P=0.148 | |INCIDENTAL TUMOR | P<0.001 ** P=0.041 * P<0.001 ** | P=0.147 P=0.261 P=0.198 | |LOGISTIC REGRESSION | P<0.001 ** P=0.037 * P<0.001 ** | P=0.151 P=0.261 P=0.193 | |COCHRAN-ARMITAGE | P<0.001 ** | P=0.258 | |FISHER EXACT | P=0.010 * P<0.001 ** | P=0.275 P=0.287 | |=================================================================================================================================| | | |Liver | | Hepatocellular Carcinoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/32 (6%) 10/47 (21%) 12/48 (25%) | 0/33 (0%) 1/49 (2%) 1/50 (2%) | |ADJUSTED (b) | 11.4% 33.2% 39.7% | 0.0% 2.4% 2.5% | |TERMINAL (d) | 0/12 (0%) 5/24 (21%) 6/22 (27%) | 0/28 (0%) 0/41 (0%) 0/32 (0%) | |FIRST INCIDENCE (DAYS) | 498 521 512 | --- 707 673 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.068 P=0.189 P=0.087 | P=0.369 P=0.574 P=0.557 | |INCIDENTAL TUMOR | P=0.050 P=0.112 P=0.066 | P=0.641N P=0.773 P=0.923 | |LOGISTIC REGRESSION | P=0.046 * P=0.127 P=0.049 * | P=0.412 P=0.582 P=0.584 | |COCHRAN-ARMITAGE | P=0.031 * | P=0.413 | |FISHER EXACT | P=0.062 P=0.027 * | P=0.598 P=0.602 | |=================================================================================================================================| DATE: 09/09/94 EXPERIMENT: 05073 TEST: 01 PAGE 5 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 100 PPM 200 PPM | 0 PPM 100 PPM 200 PPM | | | | | |=================================================================================================================================| | | |Liver | | Hepatocellular Carcinoma or Hepatocellular Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 7/32 (22%) 26/47 (55%) 37/48 (77%) | 3/33 (9%) 9/49 (18%) 9/50 (18%) | |ADJUSTED (b) | 35.8% 75.7% 89.7% | 10.7% 21.4% 25.9% | |TERMINAL (d) | 2/12 (17%) 16/24 (67%) 18/22 (82%) | 3/28 (11%) 8/41 (20%) 7/32 (22%) | |FIRST INCIDENCE (DAYS) | 330 413 376 | 729 (T) 707 673 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P<0.001 ** P=0.067 P=0.002 ** | P=0.080 P=0.193 P=0.104 | |INCIDENTAL TUMOR | P<0.001 ** P=0.015 * P<0.001 ** | P=0.170 P=0.227 P=0.185 | |LOGISTIC REGRESSION | P<0.001 ** P=0.015 * P<0.001 ** | P=0.131 P=0.203 P=0.154 | |COCHRAN-ARMITAGE | P<0.001 ** | P=0.198 | |FISHER EXACT | P=0.003 ** P<0.001 ** | P=0.200 P=0.211 | |=================================================================================================================================| | | |Liver | | Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 7/32 (22%) 26/47 (55%) 37/48 (77%) | 3/33 (9%) 9/49 (18%) 9/50 (18%) | |ADJUSTED (b) | 35.8% 75.7% 89.7% | 10.7% 21.4% 25.9% | |TERMINAL (d) | 2/12 (17%) 16/24 (67%) 18/22 (82%) | 3/28 (11%) 8/41 (20%) 7/32 (22%) | |FIRST INCIDENCE (DAYS) | 330 413 376 | 729 (T) 707 673 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P<0.001 ** P=0.067 P=0.002 ** | P=0.080 P=0.193 P=0.104 | |INCIDENTAL TUMOR | P<0.001 ** P=0.015 * P<0.001 ** | P=0.170 P=0.227 P=0.185 | |LOGISTIC REGRESSION | P<0.001 ** P=0.015 * P<0.001 ** | P=0.131 P=0.203 P=0.154 | |COCHRAN-ARMITAGE | P<0.001 ** | P=0.198 | |FISHER EXACT | P=0.003 ** P<0.001 ** | P=0.200 P=0.211 | |=================================================================================================================================| DATE: 09/09/94 EXPERIMENT: 05073 TEST: 01 PAGE 6 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 100 PPM 200 PPM | 0 PPM 100 PPM 200 PPM | | | | | |=================================================================================================================================| | | |Lung | | Alveolar/Bronchiolar Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/33 (6%) 1/18 (6%) 6/49 (12%) | 0/35 (0%) 1/5 (20%) 2/50 (4%) | |ADJUSTED (b) | 16.7% 100.0% 27.3% | 0.0% 100.0% 6.3% | |TERMINAL (d) | 2/12 (17%) 1/1 (100%) 6/22 (27%) | 0/29 (0%) 1/1 (100%) 2/32 (6%) | |FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 729 (T) | --- 729 (T) 729 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.354 P=0.261 P=0.394 | P=0.211 P=0.005 ** P=0.260 | |INCIDENTAL TUMOR | P=0.354 P=0.261 P=0.394 | P=0.211 P=0.005 ** P=0.260 | |LOGISTIC REGRESSION | P=0.354 P=0.261 P=0.394 | P=0.211 P=0.005 ** P=0.260 | |COCHRAN-ARMITAGE | P=0.210 | P=0.270 | |FISHER EXACT | P=0.718N P=0.299 | P=0.125 P=0.343 | |=================================================================================================================================| | | |Lung | | Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/33 (6%) 2/18 (11%) 6/49 (12%) | 1/35 (3%) 1/5 (20%) 3/50 (6%) | |ADJUSTED (b) | 16.7% 100.0% 27.3% | 3.4% 100.0% 8.9% | |TERMINAL (d) | 2/12 (17%) 1/1 (100%) 6/22 (27%) | 1/29 (3%) 1/1 (100%) 2/32 (6%) | |FIRST INCIDENCE (DAYS) | 729 (T) 543 729 (T) | 729 (T) 729 (T) 694 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.388 P=0.174 P=0.394 | P=0.275 P=0.041 * P=0.353 | |INCIDENTAL TUMOR | P=0.367 P=0.089 P=0.394 | P=0.404 P=0.041 * P=0.492 | |LOGISTIC REGRESSION | P=0.424 P=0.162 P=0.394 | P=0.334 P=0.041 * P=0.400 | |COCHRAN-ARMITAGE | P=0.239 | P=0.374 | |FISHER EXACT | P=0.443 P=0.299 | P=0.237 P=0.453 | |=================================================================================================================================| DATE: 09/09/94 EXPERIMENT: 05073 TEST: 01 PAGE 7 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 100 PPM 200 PPM | 0 PPM 100 PPM 200 PPM | | | | | |=================================================================================================================================| | | |Mammary Gland | | Carcinoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 0/35 (0%) 0/49 (0%) 0/49 (0%) | 3/35 (9%) 2/50 (4%) 2/50 (4%) | |ADJUSTED (b) | 0.0% 0.0% 0.0% | 10.3% 4.6% 5.1% | |TERMINAL (d) | 0/12 (0%) 0/24 (0%) 0/22 (0%) | 3/29 (10%) 1/41 (2%) 1/32 (3%) | |FIRST INCIDENCE (DAYS) | --- --- --- | 729 (T) 656 356 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | (e) (e) (e) | P=0.333N P=0.339N P=0.429N | |INCIDENTAL TUMOR | (e) (e) (e) | P=0.278N P=0.256N P=0.464N | |LOGISTIC REGRESSION | (e) (e) (e) | P=0.261N P=0.333N P=0.337N | |COCHRAN-ARMITAGE | (e) | P=0.264N | |FISHER EXACT | (e) (e) | P=0.334N P=0.334N | |=================================================================================================================================| | | |Ovary | | Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | | 2/30 (7%) 1/23 (4%) 0/48 (0%) | |ADJUSTED (b) | | 7.7% 5.6% 0.0% | |TERMINAL (d) | | 2/26 (8%) 1/18 (6%) 0/32 (0%) | |FIRST INCIDENCE (DAYS) | | 729 (T) 729 (T) --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | | P=0.121N P=0.629N P=0.193N | |INCIDENTAL TUMOR | | P=0.121N P=0.629N P=0.193N | |LOGISTIC REGRESSION | | P=0.121N P=0.629N P=0.193N | |COCHRAN-ARMITAGE | | P=0.083N | |FISHER EXACT | | P=0.600N P=0.145N | |=================================================================================================================================| DATE: 09/09/94 EXPERIMENT: 05073 TEST: 01 PAGE 8 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 100 PPM 200 PPM | 0 PPM 100 PPM 200 PPM | | | | | |=================================================================================================================================| | | |Ovary | | Luteoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | | 1/30 (3%) 2/23 (9%) 1/48 (2%) | |ADJUSTED (b) | | 3.8% 11.1% 3.1% | |TERMINAL (d) | | 1/26 (4%) 2/18 (11%) 1/32 (3%) | |FIRST INCIDENCE (DAYS) | | 729 (T) 729 (T) 729 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | | P=0.543N P=0.371 P=0.715N | |INCIDENTAL TUMOR | | P=0.543N P=0.371 P=0.715N | |LOGISTIC REGRESSION | | P=0.543N P=0.371 P=0.715N | |COCHRAN-ARMITAGE | | P=0.450N | |FISHER EXACT | | P=0.400 P=0.624N | |=================================================================================================================================| | | |Pituitary Gland: Pars Distalis or Unspecified Site | | Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/29 (0%) 0/12 (0%) 0/41 (0%) | 11/32 (34%) 8/14 (57%) 5/39 (13%) | |ADJUSTED (b) | 0.0% 0.0% 0.0% | 37.7% 72.7% 17.6% | |TERMINAL (d) | 0/12 (0%) 0/0 0/21 (0%) | 10/28 (36%) 8/11 (73%) 3/24 (13%) | |FIRST INCIDENCE (DAYS) | --- --- --- | 605 729 (T) 695 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | (e) (e) (e) | P=0.118N P=0.110 P=0.115N | |INCIDENTAL TUMOR | (e) (e) (e) | P=0.057N P=0.044 * P=0.042N* | |LOGISTIC REGRESSION | (e) (e) (e) | P=0.043N* P=0.092 P=0.044N* | |COCHRAN-ARMITAGE | (e) | P=0.024N* | |FISHER EXACT | (e) (e) | P=0.132 P=0.030N* | |=================================================================================================================================| DATE: 09/09/94 EXPERIMENT: 05073 TEST: 01 PAGE 9 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 100 PPM 200 PPM | 0 PPM 100 PPM 200 PPM | | | | | |=================================================================================================================================| | | |Pituitary Gland: Pars Distalis or Unspecified Site | | Carcinoma or Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/29 (0%) 0/12 (0%) 0/41 (0%) | 11/32 (34%) 8/14 (57%) 6/39 (15%) | |ADJUSTED (b) | 0.0% 0.0% 0.0% | 37.7% 72.7% 19.7% | |TERMINAL (d) | 0/12 (0%) 0/0 0/21 (0%) | 10/28 (36%) 8/11 (73%) 3/24 (13%) | |FIRST INCIDENCE (DAYS) | --- --- --- | 605 729 (T) 681 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | (e) (e) (e) | P=0.180N P=0.110 P=0.178N | |INCIDENTAL TUMOR | (e) (e) (e) | P=0.061N P=0.044 * P=0.042N* | |LOGISTIC REGRESSION | (e) (e) (e) | P=0.071N P=0.092 P=0.077N | |COCHRAN-ARMITAGE | (e) | P=0.043N* | |FISHER EXACT | (e) (e) | P=0.132 P=0.056N | |=================================================================================================================================| | | |Skin: Subcutaneous Tissue | | Fibroma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 0/35 (0%) 2/49 (4%) 3/49 (6%) | 0/35 (0%) 0/50 (0%) 0/50 (0%) | |ADJUSTED (b) | 0.0% 7.6% 12.3% | 0.0% 0.0% 0.0% | |TERMINAL (d) | 0/12 (0%) 1/24 (4%) 2/22 (9%) | 0/29 (0%) 0/41 (0%) 0/32 (0%) | |FIRST INCIDENCE (DAYS) | --- 693 654 | --- --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.161 P=0.420 P=0.249 | (e) (e) (e) | |INCIDENTAL TUMOR | P=0.153 P=0.435 P=0.254 | (e) (e) (e) | |LOGISTIC REGRESSION | P=0.160 P=0.411 P=0.250 | (e) (e) (e) | |COCHRAN-ARMITAGE | P=0.127 | (e) | |FISHER EXACT | P=0.337 P=0.193 | (e) (e) | |=================================================================================================================================| DATE: 09/09/94 EXPERIMENT: 05073 TEST: 01 PAGE 10 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 100 PPM 200 PPM | 0 PPM 100 PPM 200 PPM | | | | | |=================================================================================================================================| | | |Skin: Subcutaneous Tissue | | Fibrosarcoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 2/35 (6%) 10/49 (20%) 3/49 (6%) | 0/35 (0%) 1/50 (2%) 2/50 (4%) | |ADJUSTED (b) | 14.4% 31.9% 12.9% | 0.0% 2.3% 5.0% | |TERMINAL (d) | 1/12 (8%) 5/24 (21%) 2/22 (9%) | 0/29 (0%) 0/41 (0%) 0/32 (0%) | |FIRST INCIDENCE (DAYS) | 675 521 701 | --- 705 658 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.338N P=0.187 P=0.597N | P=0.170 P=0.579 P=0.305 | |INCIDENTAL TUMOR | P=0.358N P=0.110 P=0.588N | P=0.576 P=0.814 P=0.795 | |LOGISTIC REGRESSION | P=0.347N P=0.128 P=0.587N | P=0.194 P=0.574 P=0.320 | |COCHRAN-ARMITAGE | P=0.489N | P=0.193 | |FISHER EXACT | P=0.053 P=0.657 | P=0.588 P=0.343 | |=================================================================================================================================| | | |Skin: Subcutaneous Tissue | | Neurofibrosarcoma, Fibrosarcoma, Sarcoma, | | Neurofibroma, or Fibroma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 4/35 (11%) 12/49 (24%) 10/49 (20%) | 0/35 (0%) 1/50 (2%) 2/50 (4%) | |ADJUSTED (b) | 24.2% 37.8% 36.1% | 0.0% 2.3% 5.0% | |TERMINAL (d) | 1/12 (8%) 6/24 (25%) 6/22 (27%) | 0/29 (0%) 0/41 (0%) 0/32 (0%) | |FIRST INCIDENCE (DAYS) | 552 521 446 | --- 705 658 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.406 P=0.358 P=0.415 | P=0.170 P=0.579 P=0.305 | |INCIDENTAL TUMOR | P=0.382 P=0.250 P=0.398 | P=0.576 P=0.814 P=0.795 | |LOGISTIC REGRESSION | P=0.349 P=0.239 P=0.350 | P=0.194 P=0.574 P=0.320 | |COCHRAN-ARMITAGE | P=0.222 | P=0.193 | |FISHER EXACT | P=0.110 P=0.216 | P=0.588 P=0.343 | |=================================================================================================================================| DATE: 09/09/94 EXPERIMENT: 05073 TEST: 01 PAGE 11 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 100 PPM 200 PPM | 0 PPM 100 PPM 200 PPM | | | | | |=================================================================================================================================| | | |Skin: Subcutaneous Tissue | | Neurofibrosarcoma, Fibrosarcoma, or Sarcoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 4/35 (11%) 10/49 (20%) 7/49 (14%) | 0/35 (0%) 1/50 (2%) 2/50 (4%) | |ADJUSTED (b) | 24.2% 31.9% 25.4% | 0.0% 2.3% 5.0% | |TERMINAL (d) | 1/12 (8%) 5/24 (21%) 4/22 (18%) | 0/29 (0%) 0/41 (0%) 0/32 (0%) | |FIRST INCIDENCE (DAYS) | 552 521 446 | --- 705 658 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.467N P=0.495 P=0.580N | P=0.170 P=0.579 P=0.305 | |INCIDENTAL TUMOR | P=0.489N P=0.373 P=0.601N | P=0.576 P=0.814 P=0.795 | |LOGISTIC REGRESSION | P=0.533N P=0.367 P=0.609 | P=0.194 P=0.574 P=0.320 | |COCHRAN-ARMITAGE | P=0.465 | P=0.193 | |FISHER EXACT | P=0.216 P=0.484 | P=0.588 P=0.343 | |=================================================================================================================================| | | |Skin: Subcutaneous Tissue | | Sarcoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 2/35 (6%) 0/49 (0%) 4/49 (8%) | 0/35 (0%) 0/50 (0%) 0/50 (0%) | |ADJUSTED (b) | 11.5% 0.0% 13.5% | 0.0% 0.0% 0.0% | |TERMINAL (d) | 0/12 (0%) 0/24 (0%) 2/22 (9%) | 0/29 (0%) 0/41 (0%) 0/32 (0%) | |FIRST INCIDENCE (DAYS) | 552 --- 446 | --- --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.417 P=0.094N P=0.652 | (e) (e) (e) | |INCIDENTAL TUMOR | P=0.415 P=0.091N P=0.622 | (e) (e) (e) | |LOGISTIC REGRESSION | P=0.315 P=0.167N P=0.522 | (e) (e) (e) | |COCHRAN-ARMITAGE | P=0.323 | (e) | |FISHER EXACT | P=0.171N P=0.509 | (e) (e) | |=================================================================================================================================| DATE: 09/09/94 EXPERIMENT: 05073 TEST: 01 PAGE 12 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 100 PPM 200 PPM | 0 PPM 100 PPM 200 PPM | | | | | |=================================================================================================================================| | | |Spleen | | Hemangiosarcoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/30 (0%) 0/23 (0%) 0/46 (0%) | 0/33 (0%) 1/13 (8%) 3/47 (6%) | |ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 14.3% 8.8% | |TERMINAL (d) | 0/12 (0%) 0/5 (0%) 0/22 (0%) | 0/28 (0%) 1/7 (14%) 1/32 (3%) | |FIRST INCIDENCE (DAYS) | --- --- --- | --- 729 (T) 710 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | (e) (e) (e) | P=0.091 P=0.227 P=0.150 | |INCIDENTAL TUMOR | (e) (e) (e) | P=0.261 P=0.227 P=0.407 | |LOGISTIC REGRESSION | (e) (e) (e) | P=0.137 P=0.227 P=0.180 | |COCHRAN-ARMITAGE | (e) | P=0.145 | |FISHER EXACT | (e) (e) | P=0.283 P=0.197 | |=================================================================================================================================| | | |Stomach, Forestomach | | Squamous Cell Papilloma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 0/35 (0%) 0/49 (0%) 1/49 (2%) | 5/35 (14%) 0/50 (0%) 0/50 (0%) | |ADJUSTED (b) | 0.0% 0.0% 4.5% | 17.2% 0.0% 0.0% | |TERMINAL (d) | 0/12 (0%) 0/24 (0%) 1/22 (5%) | 5/29 (17%) 0/41 (0%) 0/32 (0%) | |FIRST INCIDENCE (DAYS) | --- --- 729 (T) | 729 (T) --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.330 (e) P=0.621 | P=0.003N** P=0.012N* P=0.025N* | |INCIDENTAL TUMOR | P=0.330 (e) P=0.621 | P=0.003N** P=0.012N* P=0.025N* | |LOGISTIC REGRESSION | P=0.330 (e) P=0.621 | P=0.003N** P=0.012N* P=0.025N* | |COCHRAN-ARMITAGE | P=0.307 | P=0.002N** | |FISHER EXACT | (e) P=0.583 | P=0.010N** P=0.010N** | |=================================================================================================================================| DATE: 09/09/94 EXPERIMENT: 05073 TEST: 01 PAGE 13 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 100 PPM 200 PPM | 0 PPM 100 PPM 200 PPM | | | | | |=================================================================================================================================| | | |All Organs | | Hemangioma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 1/35 (3%) 0/49 (0%) 2/49 (4%) | 0/35 (0%) 0/50 (0%) 0/50 (0%) | |ADJUSTED (b) | 3.8% 0.0% 7.2% | 0.0% 0.0% 0.0% | |TERMINAL (d) | 0/12 (0%) 0/24 (0%) 0/22 (0%) | 0/29 (0%) 0/41 (0%) 0/32 (0%) | |FIRST INCIDENCE (DAYS) | 426 --- 584 | --- --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.510 P=0.400N P=0.706 | (e) (e) (e) | |INCIDENTAL TUMOR | P=0.515 P=0.581N P=0.707 | (e) (e) (e) | |LOGISTIC REGRESSION | P=0.418 P=0.554N P=0.608 | (e) (e) (e) | |COCHRAN-ARMITAGE | P=0.446 | (e) | |FISHER EXACT | P=0.417N P=0.625 | (e) (e) | |=================================================================================================================================| | | |All Organs | | Hemangiosarcoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 0/35 (0%) 2/49 (4%) 1/49 (2%) | 0/35 (0%) 3/50 (6%) 6/50 (12%) | |ADJUSTED (b) | 0.0% 8.3% 4.5% | 0.0% 6.8% 17.1% | |TERMINAL (d) | 0/12 (0%) 2/24 (8%) 1/22 (5%) | 0/29 (0%) 2/41 (5%) 3/32 (9%) | |FIRST INCIDENCE (DAYS) | --- 729 (T) 729 (T) | --- 424 694 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.505 P=0.400 P=0.621 | P=0.013 * P=0.194 P=0.029 * | |INCIDENTAL TUMOR | P=0.505 P=0.400 P=0.621 | P=0.054 P=0.317 P=0.106 | |LOGISTIC REGRESSION | P=0.505 P=0.400 P=0.621 | P=0.024 * P=0.152 P=0.036 * | |COCHRAN-ARMITAGE | P=0.446 | P=0.024 * | |FISHER EXACT | P=0.337 P=0.583 | P=0.198 P=0.036 * | |=================================================================================================================================| DATE: 09/09/94 EXPERIMENT: 05073 TEST: 01 PAGE 14 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 100 PPM 200 PPM | 0 PPM 100 PPM 200 PPM | | | | | |=================================================================================================================================| | | |All Organs | | Hemangiosarcoma or Hemangioma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 1/35 (3%) 2/49 (4%) 3/49 (6%) | 0/35 (0%) 3/50 (6%) 6/50 (12%) | |ADJUSTED (b) | 3.8% 8.3% 11.4% | 0.0% 6.8% 17.1% | |TERMINAL (d) | 0/12 (0%) 2/24 (8%) 1/22 (5%) | 0/29 (0%) 2/41 (5%) 3/32 (9%) | |FIRST INCIDENCE (DAYS) | 426 729 (T) 584 | --- 424 694 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.403 P=0.712 P=0.539 | P=0.013 * P=0.194 P=0.029 * | |INCIDENTAL TUMOR | P=0.407 P=0.612 P=0.538 | P=0.054 P=0.317 P=0.106 | |LOGISTIC REGRESSION | P=0.366 P=0.661 P=0.460 | P=0.024 * P=0.152 P=0.036 * | |COCHRAN-ARMITAGE | P=0.323 | P=0.024 * | |FISHER EXACT | P=0.625 P=0.444 | P=0.198 P=0.036 * | |=================================================================================================================================| | | |All Organs | | Malignant Lymphoma And Histiocytic Sarcoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 1/35 (3%) 2/49 (4%) 6/49 (12%) | 14/35 (40%) 9/50 (18%) 18/50 (36%) | |ADJUSTED (b) | 8.3% 6.6% 24.1% | 45.0% 21.3% 44.5% | |TERMINAL (d) | 1/12 (8%) 1/24 (4%) 4/22 (18%) | 12/29 (41%) 8/41 (20%) 11/32 (34%) | |FIRST INCIDENCE (DAYS) | 729 (T) 545 640 | 635 692 224 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.093 P=0.726N P=0.221 | P=0.349 P=0.026N* P=0.457 | |INCIDENTAL TUMOR | P=0.093 P=0.612 P=0.238 | P=0.509 P=0.055N P=0.539N | |LOGISTIC REGRESSION | P=0.085 P=0.706 P=0.217 | P=0.501N P=0.019N* P=0.445N | |COCHRAN-ARMITAGE | P=0.060 | P=0.495N | |FISHER EXACT | P=0.625 P=0.127 | P=0.023N* P=0.440N | |=================================================================================================================================| DATE: 09/09/94 EXPERIMENT: 05073 TEST: 01 PAGE 15 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 100 PPM 200 PPM | 0 PPM 100 PPM 200 PPM | | | | | |=================================================================================================================================| | | |All Organs | | Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, | | NOS, or Undifferentiated Cell Type | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 1/35 (3%) 2/49 (4%) 6/49 (12%) | 14/35 (40%) 9/50 (18%) 18/50 (36%) | |ADJUSTED (b) | 8.3% 6.6% 24.1% | 45.0% 21.3% 44.5% | |TERMINAL (d) | 1/12 (8%) 1/24 (4%) 4/22 (18%) | 12/29 (41%) 8/41 (20%) 11/32 (34%) | |FIRST INCIDENCE (DAYS) | 729 (T) 545 640 | 635 692 224 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.093 P=0.726N P=0.221 | P=0.349 P=0.026N* P=0.457 | |INCIDENTAL TUMOR | P=0.093 P=0.612 P=0.238 | P=0.509 P=0.055N P=0.539N | |LOGISTIC REGRESSION | P=0.085 P=0.706 P=0.217 | P=0.501N P=0.019N* P=0.445N | |COCHRAN-ARMITAGE | P=0.060 | P=0.495N | |FISHER EXACT | P=0.625 P=0.127 | P=0.023N* P=0.440N | |=================================================================================================================================| | | |All Organs | | Benign Tumors | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 11/35 (31%) 28/49 (57%) 38/49 (78%) | 17/35 (49%) 17/50 (34%) 19/50 (38%) | |ADJUSTED (b) | 56.4% 84.5% 97.3% | 56.5% 41.5% 52.6% | |TERMINAL (d) | 5/12 (42%) 19/24 (79%) 21/22 (95%) | 16/29 (55%) 17/41 (41%) 15/32 (47%) | |FIRST INCIDENCE (DAYS) | 330 413 376 | 605 729 (T) 681 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.004 ** P=0.251 P=0.014 * | P=0.523 P=0.129N P=0.581N | |INCIDENTAL TUMOR | P<0.001 ** P=0.109 P<0.001 ** | P=0.391N P=0.189N P=0.333N | |LOGISTIC REGRESSION | P<0.001 ** P=0.122 P<0.001 ** | P=0.363N P=0.107N P=0.352N | |COCHRAN-ARMITAGE | P<0.001 ** | P=0.224N | |FISHER EXACT | P=0.017 * P<0.001 ** | P=0.130N P=0.227N | |=================================================================================================================================| DATE: 09/09/94 EXPERIMENT: 05073 TEST: 01 PAGE 16 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | 0 PPM 100 PPM 200 PPM | 0 PPM 100 PPM 200 PPM | | | | | |=================================================================================================================================| | | |All Organs | | Malignant Tumors | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 8/35 (23%) 27/49 (55%) 26/49 (53%) | 19/35 (54%) 17/50 (34%) 30/50 (60%) | |ADJUSTED (b) | 41.6% 70.4% 75.5% | 59.2% 36.0% 63.5% | |TERMINAL (d) | 2/12 (17%) 13/24 (54%) 14/22 (64%) | 16/29 (55%) 11/41 (27%) 15/32 (47%) | |FIRST INCIDENCE (DAYS) | 475 521 446 | 605 382 224 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.100 P=0.128 P=0.094 | P=0.092 P=0.071N P=0.152 | |INCIDENTAL TUMOR | P=0.045 * P=0.016 * P=0.038 * | P=0.437 P=0.039N* P=0.489 | |LOGISTIC REGRESSION | P=0.043 * P=0.024 * P=0.024 * | P=0.431 P=0.049N* P=0.578N | |COCHRAN-ARMITAGE | P=0.007 ** | P=0.244 | |FISHER EXACT | P=0.003 ** P=0.005 ** | P=0.051N P=0.381 | |=================================================================================================================================| | | |All Organs | | Malignant and Benign Tumors | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 17/35 (49%) 38/49 (78%) 45/49 (92%) | 28/35 (80%) 30/50 (60%) 37/50 (74%) | |ADJUSTED (b) | 75.2% 90.4% 100.0% | 87.5% 63.7% 77.0% | |TERMINAL (d) | 7/12 (58%) 20/24 (83%) 22/22 (100%) | 25/29 (86%) 24/41 (59%) 21/32 (66%) | |FIRST INCIDENCE (DAYS) | 330 413 376 | 605 382 224 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.044 * P=0.407 P=0.077 | P=0.208 P=0.069N P=0.287 | |INCIDENTAL TUMOR | P<0.001 ** P=0.038 * P<0.001 ** | P=0.332N P=0.036N* P=0.345N | |LOGISTIC REGRESSION | P<0.001 ** P=0.051 P<0.001 ** | P=0.417N P=0.031N* P=0.363N | |COCHRAN-ARMITAGE | P<0.001 ** | P=0.400N | |FISHER EXACT | P=0.006 ** P<0.001 ** | P=0.042N* P=0.354N | |=================================================================================================================================| DATE: 09/09/94 EXPERIMENT: 05073 TEST: 01 PAGE 17 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL TERMINAL SACRIFICE AT 105 WEEKS (a) Number of tumor-bearing animals / number of animals examined at site. (b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for intercurrent mortality. (d) Observed incidence at terminal kill. (f) Beneath the control incidence are the P-values associated with the trend test. Beneath the dosed group incidence are the P-values corresponding to pairwise comparisons between the controls and that dosed group. The life table analysis regards tumors in animals dying prior to terminal kill as being (directly or indirectly) the cause of death. The incidental tumor test regards these lesions as non-fatal. Logistic regression is an alternative method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage and Fisher's exact tests compare directly the overall incidence rates. For all tests, a negative trend is indicated by "N". (e) Value of Statistic cannot be computed. (I) Interim sacrifice (T) Terminal sacrifice # Tumor rates based on number of animals necropsied. * To the right of any statistical result, indicates significance at (P<=0.05). ** To the right of any statistical result, indicates significance at (P<=0.01). --multipart-boundary Content-type: text/plain Range: bytes 116650-116650/116650 --multipart-boundary--