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TR 349 Mouse Pathology Tables

NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97
Route: DOSED FEED                                                                                                 Time: 13:53:06




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  87-86-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 2| 3| 2| 5| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 2| 7| 2| 3| 3|             
                                           | 0| 9| 0| 0| 9| 0| 9| 3| 1| 0| 1| 9| 5| 1| 1| 9| 1| 0| 1| 0| 9| 4| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                   X      |             
      Clear Cell Focus                     |                                                    X                     |             
      Degeneration, Cystic                 |                                                 3                        |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |    2        1  2        2     2        2  2  2  2     2                  |             
      Infarct                              |                                                 2                 2      |             
      Vacuolization Cytoplasmic            |                                                    2                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                            +                        |             
      Inflammation, Chronic                |                                                 3                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                            2     2                          4        2   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |       3                                      3  3                        |             
      Inflammation, Chronic Active         |       2                                      2  2                        |             
      Ulcer, Acute                         |                                              2  2                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 | 2  2  2  2  3  3  2  2  3  3  3  3  2  2  3  2  2  3  3  2  2  2  3  2  3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               2                                          |             
      Hypertrophy                          |             2                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 2| 3| 2| 5| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 2| 7| 2| 3| 3|             
                                           | 0| 9| 0| 0| 9| 0| 9| 3| 1| 0| 1| 9| 5| 1| 1| 9| 1| 0| 1| 0| 9| 4| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Pars Distalis, Cyst                  |                                           X                              |             
      Pars Distalis, Hyperplasia           |          3              2        2           2              2        2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                 4  3     2               |             
      Follicular Cell, Hyperplasia         |       2           2           2                 3  3     3               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  M  +  +  +  I  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       | X     X                 X     X                 X                       X|             
      Periovarian Tissue, Cyst             |             X                                                        X   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                3                                                         |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular, Multifocal           | 3     3  3  3  3  3     4  3  3  3     3  3  2  3  2  3  3  3  2  2  3  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis               | 2           2                    2        2  2        2                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |       2                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |    3                                                                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                      2                                                   |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |    4                                                                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  M  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                2  3                             3           3            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Ulcer                                |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 2| 3| 2| 5| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 2| 7| 2| 3| 3|             
                                           | 0| 9| 0| 0| 9| 0| 9| 3| 1| 0| 1| 9| 5| 1| 1| 9| 1| 0| 1| 0| 9| 4| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |                               2  2                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Foreign Body                  |                      2                                                   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 1  1  1        1     4        1  1              2  1  1                 1|             
      Glomerulus, Amyloid Deposition       |                      4                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 6| 1| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 3| 2| 0| 2| 3| 3| 8| 3| 3|                                            |            |
                                           | 9| 1| 9| 5| 9| 0| 5| 3| 0| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  A  M  +  +                                             |  33        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  A  A  +  +  A  A  +  +                                             |  29        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  A  +  +  +  M  +  +  +                                             |  32        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +  +  M  +  +  +                                             |  30        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  A  +  +  +  M  +  +  +                                             |  32        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  +  +  +  M  +  +  +                                             |  31        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  A  +  +  +  M  +  +  +                                             |  32        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +  +  M  +  +  +                                             |  32        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  M  +  +  +                                             |  31        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +  +  M  +  +  +                                             |  32        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  A  +  +  +  A  +  +  +                                             |  33        |
      Basophilic Focus                     |                                                                          |      1     |
      Clear Cell Focus                     |                                                                          |      1     |
      Degeneration, Cystic                 |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      | 2           2           2  2                                             |     14  1.9|
      Infarct                              |          2           2                                                   |      4  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |   3        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  A  I  +  +  M  +  +  +                                             |  31        |
      Acinus, Atrophy                      |                                                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  A  +  +  +  +  M  +  +                                             |  33        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  A  +  +  +  M  +  +  +                                             |  32        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  A  +  +  +  M  +  +  +                                             |  32        |
      Acanthosis                           |                            4                                             |      4  3.3|
      Inflammation, Chronic Active         |                                                                          |      3  2.0|
      Ulcer, Acute                         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  A  +  +  +  M  +  +  +                                             |  32        |
      Dysplasia                            |             2                                                            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  35        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  M  +  +  +                                             |  34        |
      Capsule, Hyperplasia                 | 3  3  1     3  3     2  3  3                                             |     33  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  A  +  +  +  M  +  +  +                                             |  33        |
      Hyperplasia                          |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   5                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 6| 1| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 3| 2| 0| 2| 3| 3| 8| 3| 3|                                            |            |
                                           | 9| 1| 9| 5| 9| 0| 5| 3| 0| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hypertrophy                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  A  +  +  +  M  +  +  +                                             |  33        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  A  I  +  +  M  +  +  +                                             |  31        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  M  +  +                                             |  30        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +                                             |  32        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           | 3  2     3              3                                                |     10  2.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  M  M  +  +                                             |  33        |
      Inflammation, Chronic                |                                                                          |      3  3.0|
      Follicular Cell, Hyperplasia         |                            3                                             |      7  2.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  A  +  +  +  M  +  +  +                                             |  30        |
      Follicle, Cyst                       |    X                 X                                                   |      8     |
      Periovarian Tissue, Cyst             |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  A  +  +  +  M  +  +  +                                             |  33        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular, Multifocal           | 3  3        4  2        3  4                                             |     28  2.9|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Femoral, Myelofibrosis               |    2                    2                                                |      8  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  M  +  +  +  +  M  +  +                                             |  33        |
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  M  +  +                                             |  33        |
      Depletion Lymphoid                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  A  +  +  +  A  +  +  +                                             |  33        |
      Depletion Lymphoid                   |                      2                                                   |      2  2.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           |                3                                                         |      2  3.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  M  M  +                                             |  28        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 6| 1| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 3| 2| 0| 2| 3| 3| 8| 3| 3|                                            |            |
                                           | 9| 1| 9| 5| 9| 0| 5| 3| 0| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  A  +  +  +  M  M  +  +                                             |  30        |
      Hyperplasia, Cystic                  | 2        2                 2                                             |      7  2.4|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  A  +  +  +  A  +  +  +                                             |  33        |
      Acanthosis                           |                3                                                         |      1  3.0|
      Ulcer                                |                3                                                         |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  35        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  A  +  +  +  A  +  +  +                                             |  33        |
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Lymphocyte                      |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  35        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Lumen, Foreign Body                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  A  M  +  +                                             |  33        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  A  +  +  +  +  +  +  +                                             |  32        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  A  +  +  +  A  +  +  +                                             |  33        |
      Nephropathy, Chronic                 |                1           2                                             |     13  1.4|
      Glomerulus, Amyloid Deposition       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  A  +  +  +  M  +  +  +                                             |  32        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 2| 2| 2| 3| 2| 3| 3| 5| 3| 3| 3| 2| 3| 3|             
                                           | 9| 0| 1| 0| 1| 9| 0| 1| 5| 0| 0| 9| 9| 9| 1| 9| 0| 1| 6| 0| 1| 0| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    100 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                   +                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                   +                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                   +                                                      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |             X              X                                            X|             
      Degeneration, Cystic                 |                                        4                                 |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      | 2        2  2                                                            |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic Active, Diffuse| 2  1  1        1  1  1     1  1  1        1  1  1     1  1  2  1  1  2  2|             
      Pigmentation, Multifocal             | 2  2  1  1     2  2        2  1  1  2  2  1  2  2  2  2     2  2     3  2|             
      Vacuolization Cytoplasmic            |             3                                                           2|             
      Bile Duct, Hyperplasia, Multifocal   |    4                                                                     |             
      Bile Duct, Inflammation, Chronic     |                                                                          |             
          Active, Multifocal               |    4                                                                     |             
      Hepatocyte, Cytomegaly, Diffuse      | 2  2  2  2  2  2  2  2     2  2  2  2  2  2  2  2  2  2  2  2  2  2  3  2|             
      Hepatocyte, Necrosis, Acute, Diffuse | 2  2  2  2  2  2  2        2  2  1  2     2  2  2  1  1  1  1  2  1  2  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                       +                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 | 3  2  2  3  3  2  3  3     2  3  3  3  3  3  3  3  3  3  3  3  3  2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Degeneration, Fatty                  |    3                                                                     |             
      Hematopoietic Cell Proliferation     | 2                                                                        |             
      Hyperplasia                          |                                                                   2      |             
      Hypertrophy                          |          3                                                              3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 2| 2| 2| 3| 2| 3| 3| 5| 3| 3| 3| 2| 3| 3|             
                                           | 9| 0| 1| 0| 1| 9| 0| 1| 5| 0| 0| 9| 9| 9| 1| 9| 0| 1| 6| 0| 1| 0| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    100 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          | 2                                                                       2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |          +  +  +  +           +  +                    +        +        +|             
      Pars Distalis, Cyst                  |                X                                                         |             
      Pars Distalis, Hyperplasia           |             3                                         3                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +     +  +  +  +  +  +  I     +     +  +              +            |             
      Inflammation, Chronic Active         |                         4                                                |             
      Mineralization                       |                                                                          |             
      Follicle, Cyst                       | X     X        X                             X              X            |             
      Periovarian Tissue, Cyst             |                   X  X     X        X     X                              |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +     +  +     +           +  +  +  +  +  +  +  +     +  +  +|             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular, Multifocal           |    2  3  3  4     3  3     3           4  3  3  3  3  3  3  3     3  3  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                                          |             
      Femoral, Myelofibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +           +        +                                                   |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    | 4           3                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +              +        +                             +                  |             
      Depletion Lymphoid                   |                                                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |                         4                             3                  |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                     +                 +                  |             
                                            __________________________________________________________________________|             
   Skin                                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 2| 2| 2| 3| 2| 3| 3| 5| 3| 3| 3| 2| 3| 3|             
                                           | 9| 0| 1| 0| 1| 9| 0| 1| 5| 0| 0| 9| 9| 9| 1| 9| 0| 1| 6| 0| 1| 0| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    100 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                                              +                           |             
                                            __________________________________________________________________________|             
   Nose                                    |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Renal Tubule, Cytoplasmic Alteration,|                                                                          |             
           Diffuse                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4|            |
                             DAY ON TEST   | 2| 2| 3| 3| 2| 3| 9| 3| 2| 8| 3| 2| 3| 2| 3| 0| 3| 2| 3| 0| 3| 5| 3| 3| 7|            |
                                           | 9| 4| 0| 0| 9| 1| 2| 1| 9| 2| 1| 9| 1| 9| 0| 5| 1| 9| 1| 7| 1| 3| 0| 0| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    100 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +                       +                                   +        +|   4        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    A                       A                                   M        A|            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    A                       +                                   +        +|   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    A                       +                                   +        A|   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    A                       +                                   +        +|   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    A                       +                                   M        +|   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    A                       +              +                    +        +|   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    A                       +                                   +        +|   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    A                       A                                   M        A|   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    A                       +              +                    +        +|   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Clear Cell Focus                     |                                                                          |      3     |
      Degeneration, Cystic                 |                                                                          |      1  4.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      | 2                 2                       2        2                 2   |      8  2.0|
      Infarct                              |    4                                         2                           |      2  3.0|
      Inflammation, Chronic Active, Diffuse|       2  2  1  2  1  2        1  2     1  1  2  1     2  2              1|     34  1.4|
      Pigmentation, Multifocal             | 1  3  2  2  1  2     2        2  2  2        2  2  1  2     1        2  2|     37  1.8|
      Vacuolization Cytoplasmic            |                         3                                                |      3  2.7|
      Bile Duct, Hyperplasia, Multifocal   |                                                                          |      1  4.0|
      Bile Duct, Inflammation, Chronic     |                                                                          |            |
          Active, Multifocal               |                                                                          |      1  4.0|
      Hepatocyte, Cytomegaly, Diffuse      | 1     2  2  1  2  1  1  2  1  1  2  2  2  2  2  2  2  2  2  2  1  2  2  1|     48  1.9|
      Hepatocyte, Necrosis, Acute, Diffuse | 1     1  1  1  1  1  1  2     1  1  1  1  1     1  1  1  2  1  1  2  2  2|     44  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                              +                           |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    A                       +                                   +        +|   4        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +                       +                                   +        +|   4        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    A                       +                                   +        +|   3        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    A                       +                                   +        +|   3        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    A                       +                                   +        +|   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +                       +                                   +        +|   4        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Capsule, Hyperplasia                 | 3  2  3  2  3  3  2  3  2     3  2  2  2  2  3  2  2  2  2  3  2  3  3  2|     48  2.6|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                      3                                                   |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4|            |
                             DAY ON TEST   | 2| 2| 3| 3| 2| 3| 9| 3| 2| 8| 3| 2| 3| 2| 3| 0| 3| 2| 3| 0| 3| 5| 3| 3| 7|            |
                                           | 9| 4| 0| 0| 9| 1| 2| 1| 9| 2| 1| 9| 1| 9| 0| 5| 1| 9| 1| 7| 1| 3| 0| 0| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    100 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Degeneration, Fatty                  |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia                          |                      2                                                   |      2  2.0|
      Hypertrophy                          |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                    2                 2   |      4  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    A                       +                                   +        +|   3        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +                       +                                   +        +|   4        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    M  +                 +  M        +                          +        +|  14        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |       3                 2                                                |      4  2.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +                       +                                   +        +|   4        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +  +     +  +        +  +           +        +  +           +        +|  23        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Mineralization                       |    3                                                                     |      1  3.0|
      Follicle, Cyst                       |       X     X                                   X  X                     |      9     |
      Periovarian Tissue, Cyst             |                X        X              X           X                    X|     10     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +     +     +  +  +  +  +        +  +  +     +  +  +     +|  37        |
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular, Multifocal           | 3     3  3  3  3     4        3  3  3  3        3  4  3     3  2  3     4|     35  3.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +                       +                                   +        +|   4        |
      Femoral, Myelofibrosis               |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +              +        +        +     +                    +  +     +|  12        |
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                     2                                    |      3  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +                       +                                   +        +|   4        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +        +              +              +        +           +  +     +|  13        |
      Depletion Lymphoid                   |                                                                         3|      1  3.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           |    3                       4                                             |      4  3.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    M              +        M                                   +        M|   2        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4|            |
                             DAY ON TEST   | 2| 2| 3| 3| 2| 3| 9| 3| 2| 8| 3| 2| 3| 2| 3| 0| 3| 2| 3| 0| 3| 5| 3| 3| 7|            |
                                           | 9| 4| 0| 0| 9| 1| 2| 1| 9| 2| 1| 9| 1| 9| 0| 5| 1| 9| 1| 7| 1| 3| 0| 0| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    100 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    M                       M                                   +        M|   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +                       +                 +                 +        +|   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +                       +                                   +        +|   4        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +              A        +                                   +        +|   4        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +                       +                                   +        +|   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +                       +                                   +        +|   4        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +                       +                                   +        +|   4        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +                       +                                   +        +|   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +              +        +        +                          +        +|   7        |
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                   3                                                      |      1  3.0|
      Renal Tubule, Cytoplasmic Alteration,|                                                                          |            |
           Diffuse                         |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    A                       +                                   +        +|   3        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 2| 1| 7| 1| 3| 3| 3| 3| 3| 9| 8| 3| 2| 9| 2| 3| 1| 2| 2| 3| 3| 9| 3|             
                                           | 4| 1| 9| 0| 3| 8| 0| 0| 1| 0| 1| 5| 2| 0| 9| 4| 9| 0| 1| 9| 9| 1| 0| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  +  +  A  +  +  +  +  +  A  A  +  +  +  +  M  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                              X                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |             2                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                               X        X              X                  |             
      Clear Cell Focus                     |          X              X              X  X                       X      |             
      Clear Cell Focus, Multiple           |       X           X        X  X                                X         |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |    2  2  2        2  2  2  2  2     2  2  2  2  2  2  2  3  2     2  2   |             
      Hyperplasia                          |          3                             3                       3         |             
      Infarct                              |    4        4                                                            |             
      Inflammation, Chronic Active, Diffuse|    2  2  2  2        2  2  2  2     2  2  2  2  2  2  2  2  2  1  2  2  2|             
      Pigmentation, Multifocal             |    2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
      Bile Duct, Hyperplasia, Multifocal   |    2     2                                                               |             
      Hepatocyte, Cytomegaly, Diffuse      |    3  3  2  2  2  2  3  3  3  3  2  3  3  3  3  3  3  3  3  3  3  3  3  3|             
      Hepatocyte, Necrosis, Acute, Diffuse |    2  2  1  4     2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Pancreas                                | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                         4|             
      Acinus, Inflammation, Chronic        |                                                                          |             
      Duct, Cyst                           |                                                                         X|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Acanthosis                           |                                                             3            |             
      Erosion                              |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                  3                                       |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 2| 1| 7| 1| 3| 3| 3| 3| 3| 9| 8| 3| 2| 9| 2| 3| 1| 2| 2| 3| 3| 9| 3|             
                                           | 4| 1| 9| 0| 3| 8| 0| 0| 1| 0| 1| 5| 2| 0| 9| 4| 9| 0| 1| 9| 9| 1| 0| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 |    3  3  3  3  3  3  2  3  2  3  2  2  3  2  3  3  3  2  3  3  3  3  3  3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                    3                     |             
      Hyperplasia                          |                            2                             2               |             
      Hypertrophy                          |                                        2        2                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            2                                1            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  +  +  +  +  M  +  +  +  +  I  +  +  +  +  +  +  M  +  M  +  M|             
      Pars Distalis, Hyperplasia           |    2  2     2              3                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |       1                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             3                                                            |             
      Inflammation, Chronic Active         |                                                          4               |             
      Follicle, Cyst                       |    X     X        X  X                       X        X           X  X   |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular, Multifocal           |    4  3           3  3  3  3  2     3  3     2  3     2  3  3  3  2  4  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                    +                     |             
      Leukocytosis                         |                                                                          |             
      Neutrophilia                         |                                                    X                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia, Neutrophil     |                                                    4                     |             
      Femoral, Myelofibrosis               |                         2  2           3                 2  2  3  2     2|             
      Sternal, Myelofibrosis               |       3                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                          |             
      Mesenteric, Hemorrhage               |                                              4                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             3                                                            |             
      Hyperplasia, Lymphoid                |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 2| 1| 7| 1| 3| 3| 3| 3| 3| 9| 8| 3| 2| 9| 2| 3| 1| 2| 2| 3| 3| 9| 3|             
                                           | 4| 1| 9| 0| 3| 8| 0| 0| 1| 0| 1| 5| 2| 0| 9| 4| 9| 0| 1| 9| 9| 1| 0| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                  3                                       |             
      Hematocyst                           |                                                       X                  |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |    3        3                       4              3     2               |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  +  M  M  M  +  +  +  +  +  M  M  +  +  +  M  M  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  +  M  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                2        2     3  2        3           3  2  3  2  2  3  2|             
                                            __________________________________________________________________________|             
   Skin                                    | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                      4   |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |                                              2                           |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                      2   |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Metaplasia, Osseous                  |          2              2                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 2| 1| 7| 1| 3| 3| 3| 3| 3| 9| 8| 3| 2| 9| 2| 3| 1| 2| 2| 3| 3| 9| 3|             
                                           | 4| 1| 9| 0| 3| 8| 0| 0| 1| 0| 1| 5| 2| 0| 9| 4| 9| 0| 1| 9| 9| 1| 0| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Nephropathy, Chronic                 |             2        1           4              1                 1      |             
      Renal Tubule, Cytoplasmic Alteration,|                                                                          |             
           Diffuse                         |                                                                          |             
      Renal Tubule, Necrosis, Acute        |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 6| 2| 7| 6| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 2| 3| 7| 2| 2| 6| 3| 3| 2| 3| 3| 2| 1| 5| 8| 3| 4| 5| 3| 2| 2|            |
                                           | 1| 1| 1| 9| 9| 0| 5| 4| 9| 1| 0| 1| 9| 0| 0| 9| 3| 6| 1| 0| 7| 8| 1| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    200 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  A  A  +  +  +  A  +  +  +|  39        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |             X                    X                                       |      5     |
      Clear Cell Focus                     |                                  X                       X               |      7     |
      Clear Cell Focus, Multiple           |    X                                      X  X                    X  X   |     10     |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      | 2  2  2  2  2  2  2                    2  2  2     2  2  2     2         |     33  2.0|
      Hyperplasia                          |                                                                          |      3  3.0|
      Infarct                              |                                                                          |      2  4.0|
      Inflammation, Chronic Active, Diffuse| 2  2  2  2  2     2     2  3  2  2  2  2  2  2  2  2  2  2  1  3  2  2  2|     44  2.0|
      Pigmentation, Multifocal             | 2  2  2  2  2     2     2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|     47  2.0|
      Bile Duct, Hyperplasia, Multifocal   |                                                                          |      2  2.0|
      Hepatocyte, Cytomegaly, Diffuse      | 3  3  2  3  3  3  3     3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3|     48  2.9|
      Hepatocyte, Necrosis, Acute, Diffuse | 2  2  2  2  2  2  3     2  2  2  3  2  3  2  3  2  2  2  2  2  2  2  2  2|     47  2.1|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Acinus, Atrophy                      |                   2        4     2  2                       2            |      6  2.7|
      Acinus, Inflammation, Chronic        |                                                                2         |      1  2.0|
      Duct, Cyst                           |                                                       X                  |      2     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Lymphoid                |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  46        |
      Acanthosis                           |             2              3                                             |      3  2.7|
      Erosion                              |                            2                                             |      1  2.0|
      Inflammation, Chronic Active         | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 6| 2| 7| 6| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 2| 3| 7| 2| 2| 6| 3| 3| 2| 3| 3| 2| 1| 5| 8| 3| 4| 5| 3| 2| 2|            |
                                           | 1| 1| 1| 9| 9| 0| 5| 4| 9| 1| 0| 1| 9| 0| 0| 9| 3| 6| 1| 0| 7| 8| 1| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    200 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  3.0|
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Capsule, Hyperplasia                 | 3  2  2  2  3  2  2  2  3  2  3  2  2  3  3  3  2  2  3  3  3  3  3  3  3|     49  2.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                                                    2                     |      2  2.5|
      Hyperplasia                          |                                                          2               |      3  2.0|
      Hypertrophy                          |                                        2  2                              |      4  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  M  +  +  M  +  M  +  +  M  +  +  M  M  +  +  +  +  M  +  +  +|  35        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  M  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  39        |
      Pars Distalis, Hyperplasia           |          2                       2  2     2              2           2   |     10  2.1|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Follicle, Cyst                       |                         X        X  X     X              X     X  X      |     15     |
      Periovarian Tissue, Cyst             | X           X              X                                             |      3     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular, Multifocal           | 2  3  3  3  4     3     3     3  2     2  3  3           2     2  2  3  3|     35  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |             +                                                            |   2        |
      Leukocytosis                         |             X                                                            |      1     |
      Neutrophilia                         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 6| 2| 7| 6| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 2| 3| 7| 2| 2| 6| 3| 3| 2| 3| 3| 2| 1| 5| 8| 3| 4| 5| 3| 2| 2|            |
                                           | 1| 1| 1| 9| 9| 0| 5| 4| 9| 1| 0| 1| 9| 0| 0| 9| 3| 6| 1| 0| 7| 8| 1| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    200 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Femoral, Hyperplasia, Neutrophil     |                                                    3                     |      2  3.5|
      Femoral, Myelofibrosis               | 2                       2     2  3     2  2                             2|     15  2.2|
      Sternal, Myelofibrosis               |                   3                                                      |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    | 3  3                                                                     |      2  3.0|
      Mesenteric, Hemorrhage               |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                    2           2         |      3  2.0|
      Hyperplasia                          |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Atrophy                              |                                                                          |      1  3.0|
      Hematocyst                           |                                                                          |      1     |
      Hyperplasia, Lymphoid                |                                                                   2      |      1  2.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           |                4           4                    4  4        3  4         |     11  3.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  M  +  +  M  +  M  +  +  +  +  +  M  +  +  +  M  M  +  +  +  +  +  +|  33        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +  +  +  M  +  M  +  +  M  +  M  +  M  +  +  +  +  +  +  +  M|  34        |
      Hyperplasia, Cystic                  | 2     3           2                          2        2  2     3  2      |     20  2.4|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ulcer                                |                                                 4                        |      1  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                 4                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Compression                          |                                                       4                  |      2  4.0|
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Lymphocyte                      |                                                       2        2         |      3  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 6| 2| 7| 6| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 2| 3| 7| 2| 2| 6| 3| 3| 2| 3| 3| 2| 1| 5| 8| 3| 4| 5| 3| 2| 2|            |
                                           | 1| 1| 1| 9| 9| 0| 5| 4| 9| 1| 0| 1| 9| 0| 0| 9| 3| 6| 1| 0| 7| 8| 1| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    200 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |                                                                   3      |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |             2                                                            |      2  2.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                                                    3              2      |      2  2.5|
      Metaplasia, Osseous                  |                                                                          |      2  2.0|
      Nephropathy, Chronic                 |          2  2           1           2                       2  2  2  2   |     13  1.8|
      Renal Tubule, Cytoplasmic Alteration,|                                                                          |            |
           Diffuse                         |                3                                                         |      1  3.0|
      Renal Tubule, Necrosis, Acute        |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Lymphoid                |                                                                   3      |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 4| 1| 7| 4| 1| 6| 4| 7| 7| 3| 5| 1| 5| 7| 2| 3| 4| 2| 3| 7|             
                             DAY ON TEST   | 3| 3| 2| 9| 2| 2| 8| 3| 2| 2| 7| 1| 3| 3| 3| 9| 0| 5| 3| 8| 6| 7| 6| 4| 3|             
                                           | 1| 1| 9| 8| 9| 7| 7| 1| 6| 6| 9| 7| 0| 0| 0| 8| 2| 2| 0| 6| 3| 5| 5| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M  M  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  A  +  +  M  +  +  A  A  A  +  +  +  A  A  A  +  A  +  +  A  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  A  +  A  +  +  A  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  M  A  +  +  A  +  +  +  +  +  A  M  A  +  A  +  +  A  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  A  A  +  A  +  +  A  A  +|             
      Parasite Metazoan                    |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  A  M  A  +  A  +  +  A  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  A  +  A  +  A  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  M  A  +  +  A  +  +  +  +  +  A  A  A  +  A  +  +  A  M  +|             
      Ulcer                                |          3                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  M  A  +  +  A  +  +  +  +  M  A  M  A  +  A  +  +  A  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  A  M  A  +  A  +  +  A  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  M  +|             
      Basophilic Focus                     |                                        X                    X            |             
      Fibrosis                             |          2                                                               |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                                                1         |             
      Infarct                              |          3                                                               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                             +            |             
      Inflammation, Chronic                |                                                             3            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  M  A  +  A  +  +  M  M  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M  M  +|             
      Inflammation, Acute                  |                      2                                                   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  A  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  A  +  +  +  M  +|             
      Cyst                                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  A  +  +  +  M  +|             
      Hyperplasia                          |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  M  +|             
      Degeneration, Chronic                |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  A  +  +  +  +  +  M  +|             
      Capsule, Hyperplasia                 | 2  2  2  1  1  2  1  2        2  2  3  2  1           2     2  2  2     2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  A  +  +  +  +  +  M  +|             
      Hypertrophy                          |    2                    2     2                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  A  +  +  +  +  +  M  +|             
      Hyperplasia                          |       2                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  M  A  +  A  +  +  A  M  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  I  M  +  +  +  M  +  A  M  M  +  +  M  +  M  M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 4| 1| 7| 4| 1| 6| 4| 7| 7| 3| 5| 1| 5| 7| 2| 3| 4| 2| 3| 7|             
                             DAY ON TEST   | 3| 3| 2| 9| 2| 2| 8| 3| 2| 2| 7| 1| 3| 3| 3| 9| 0| 5| 3| 8| 6| 7| 6| 4| 3|             
                                           | 1| 1| 9| 8| 9| 7| 7| 1| 6| 6| 9| 7| 0| 0| 0| 8| 2| 2| 0| 6| 3| 5| 5| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  M  +  M  +  +  M  M  +|             
      Pars Distalis, Cyst                  | X                                                                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A  +  +  +  +  +  +  M  M  +|             
      Follicular Cell, Hyperplasia         |    2        2                                                            |             
      Follicular Cell, Hypertrophy         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                           2                              |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                             +        +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +                    +           +                 +        +   |             
      Inflammation, Chronic Active         |          4                    4           3                              |             
      Duct, Dilatation                     |                                                                      3   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                   4              2        2     2           3            |             
      Inflammation, Chronic Active         |                               3                    3     3               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                         +     +  +  +                 +                  |             
      Dilatation                           |                         2        3  2                 2                  |             
      Inflammation, Chronic Active         |                               4                       2                  |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                   2                                                      |             
      Germinal Epithelium, Degeneration    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Neutrophilia                         |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  A  +  +  +  A  +|             
      Femoral, Hyperplasia, Neutrophil     |                                           2                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A  M  A  +  A  +  +  M  M  +|             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                        3                       4         |             
      Renal, Hyperplasia, Plasma Cell      |                                                             3            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A  M  A  +  A  +  +  M  M  +|             
      Depletion Lymphoid                   |                               2                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  A  +  +  +  +  A  M  +|             
      Depletion Lymphoid                   |                         2  3  3  3                       3              2|             
      Lymphoid Follicle, Necrosis          |                                           2                              |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |          3        3                                            3         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  M  M  +  +  M  +  M  M  +  M  M  M  +  M  M  +  M  M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 4| 1| 7| 4| 1| 6| 4| 7| 7| 3| 5| 1| 5| 7| 2| 3| 4| 2| 3| 7|             
                             DAY ON TEST   | 3| 3| 2| 9| 2| 2| 8| 3| 2| 2| 7| 1| 3| 3| 3| 9| 0| 5| 3| 8| 6| 7| 6| 4| 3|             
                                           | 1| 1| 9| 8| 9| 7| 7| 1| 6| 6| 9| 7| 0| 0| 0| 8| 2| 2| 0| 6| 3| 5| 5| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +|             
      Acanthosis                           | 3                                                                        |             
      Ulcer                                | 3                       2                 3                              |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |                         2                                                |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  | 3                                2        3        3                    3|             
      Subcutaneous Tissue, Metaplasia,     |                                                                          |             
           Osseous                         | 2                                                                        |             
      Subcutaneous Tissue, Lymphatic,      |                                                                          |             
          Dilatation                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Joint, Tarsal, Hyperostosis          | X                    X              X  X           X           X        X|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  A  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A  +  +  +  +  +  +  M  M  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 +                        |             
      Atrophy, Diffuse                     |                                                                          |             
      Lens, Cataract                       |                                                 3                        |             
      Retina, Atrophy                      |                                                 4                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M  A  +|             
      Hyperplasia, Cystic                  |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +|             
      Inflammation, Acute                  |                                                             4            |             
      Inflammation, Chronic Active         |                               2                                          |             
      Metaplasia, Osseous                  |                                                                   1      |             
      Nephropathy, Chronic                 | 1        2  1        2              1  2              2        2         |             
      Pelvis, Inflammation, Acute          |                   2                                                      |             
      Pelvis, Inflammation, Chronic Active |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 4| 1| 7| 4| 1| 6| 4| 7| 7| 3| 5| 1| 5| 7| 2| 3| 4| 2| 3| 7|             
                             DAY ON TEST   | 3| 3| 2| 9| 2| 2| 8| 3| 2| 2| 7| 1| 3| 3| 3| 9| 0| 5| 3| 8| 6| 7| 6| 4| 3|             
                                           | 1| 1| 9| 8| 9| 7| 7| 1| 6| 6| 9| 7| 0| 0| 0| 8| 2| 2| 0| 6| 3| 5| 5| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Dilatation             |                         3        3                                       |             
      Renal Tubule, Necrosis               |                2                                                         |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                  +              +        +  +        +   |             
      Calculus Micro Observation Only      |                                  X                          X            |             
      Concretion                           |                                                                      3   |             
      Inflammation, Acute                  |                                                 3           3            |             
      Inflammation, Chronic Active         |                                                          3               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Concretion                           |                                                          3               |             
      Dilatation                           |                   3              3                 3        3        3   |             
      Inflammation, Acute                  |                   2              2              2           2            |             
      Inflammation, Chronic Active         |                                                          3               |             
      Necrosis                             |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 5| 4| 5| 6| 6| 7|                                            |            |
                             DAY ON TEST   | 4| 7| 3| 3| 4| 2| 1| 0| 7| 3|                                            |            |
                                           | 4| 8| 1| 1| 2| 7| 0| 4| 5| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  32        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  M  +  A  A  A  +  +                                             |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  29        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  A  +  +  +                                             |  24        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  M  +  +  +                                             |  27        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  A  M  +  +  +                                             |  25        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  29        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  A  +  +  +                                             |  24        |
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  M  +  +  +                                             |  23        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +                                             |  26        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  32        |
      Basophilic Focus                     |                                                                          |      2     |
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                      4                                                   |      2  2.5|
      Infarct                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +                                                |   2        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  A  +  +  +                                             |  27        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  32        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  31        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  31        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  31        |
      Hyperplasia                          |                         3                                                |      1  3.0|
      Necrosis                             | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  33        |
      Degeneration, Chronic                |          2                                                               |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  31        |
      Capsule, Hyperplasia                 | 2  2  2  2  2  1     2  2  3                                             |     27  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  31        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 5| 4| 5| 6| 6| 7|                                            |            |
                             DAY ON TEST   | 4| 7| 3| 3| 4| 2| 1| 0| 7| 3|                                            |            |
                                           | 4| 8| 1| 1| 2| 7| 0| 4| 5| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hypertrophy                          |       2                    2                                             |      5  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  31        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  A  +  +  +                                             |  27        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  M  +  +  +  +                                             |  24        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  29        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  31        |
      Follicular Cell, Hyperplasia         |                   2                                                      |      3  2.0|
      Follicular Cell, Hypertrophy         |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  34        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                   +                                                      |   6        |
      Inflammation, Chronic Active         |                                                                          |      3  3.7|
      Duct, Dilatation                     |                   4                                                      |      2  3.5|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  34        |
      Inflammation, Acute                  |                      3                                                   |      6  2.7|
      Inflammation, Chronic Active         |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +           +                                                            |   7        |
      Dilatation                           |             2                                                            |      5  2.2|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  34        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Germinal Epithelium, Degeneration    | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +                    +                                                   |   2        |
      Neutrophilia                         |                      4                                                   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | A  +  +  +  +  +  +  +  +  +                                             |  30        |
      Femoral, Hyperplasia, Neutrophil     |                      3                                                   |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  M  +  +  +  +  +  +  +  +                                             |  27        |
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |          3              2  2                                             |      5  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 5| 4| 5| 6| 6| 7|                                            |            |
                             DAY ON TEST   | 4| 7| 3| 3| 4| 2| 1| 0| 7| 3|                                            |            |
                                           | 4| 8| 1| 1| 2| 7| 0| 4| 5| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +                                             |  27        |
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  30        |
      Depletion Lymphoid                   | 3              3                                                         |      8  2.8|
      Lymphoid Follicle, Necrosis          |             2                                                            |      2  2.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           |          4           4                                                   |      5  3.4|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  M  +     M  M  M  +                                             |  16        |
      Necrosis                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M                                             |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  33        |
      Acanthosis                           |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      3  2.7|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      5  2.8|
      Subcutaneous Tissue, Metaplasia,     |                                                                          |            |
           Osseous                         |                                                                          |      1  2.0|
      Subcutaneous Tissue, Lymphatic,      |                                                                          |            |
          Dilatation                       |                         3                                                |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Joint, Tarsal, Hyperostosis          | X  X  X              X                                                   |     11     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  A  +  +  +                                             |  31        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  33        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  35        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  31        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 5| 4| 5| 6| 6| 7|                                            |            |
                             DAY ON TEST   | 4| 7| 3| 3| 4| 2| 1| 0| 7| 3|                                            |            |
                                           | 4| 8| 1| 1| 2| 7| 0| 4| 5| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                +                                                         |   2        |
      Atrophy, Diffuse                     |                4                                                         |      1  4.0|
      Lens, Cataract                       |                                                                          |      1  3.0|
      Retina, Atrophy                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  M  +  +  +  +  +                                             |  29        |
      Hyperplasia, Cystic                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  33        |
      Inflammation, Acute                  |                   4                                                      |      2  4.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Nephropathy, Chronic                 |    3  2                    2                                             |     11  1.8|
      Pelvis, Inflammation, Acute          |                                                                          |      1  2.0|
      Pelvis, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Renal Tubule, Dilatation             |                                                                          |      2  3.0|
      Renal Tubule, Necrosis               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                   +                                                      |   6        |
      Calculus Micro Observation Only      |                                                                          |      2     |
      Concretion                           |                   3                                                      |      2  3.0|
      Inflammation, Acute                  |                                                                          |      2  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  34        |
      Calculus Micro Observation Only      |                   X                                                      |      1     |
      Concretion                           |                                                                          |      1  3.0|
      Dilatation                           | 2                                                                        |      6  2.8|
      Inflammation, Acute                  |                   3                                                      |      5  2.2|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 3| 5| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 3| 5| 3|             
                             DAY ON TEST   | 3| 2| 2| 2| 5| 8| 3| 0| 5| 3| 3| 2| 0| 2| 6| 3| 3| 3| 3| 3| 3| 2| 1| 7| 4|             
                                           | 6| 9| 9| 8| 0| 7| 1| 5| 6| 0| 8| 9| 8| 9| 4| 0| 1| 1| 0| 1| 0| 1| 5| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    100 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |          +  +  +        +     +                                +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |          A  A  +        +     +                                A  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large                         |          A  +  +        +     +                                +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |          A  A  +        +     +                                +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |          A  +  +        +     +                                +  A  +  +|             
      Parasite Metazoan                    |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |          A  A  M        +     +                                +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |          A  A  +        +     +                                +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |          A  A  +        +     +                                +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |          A  A  +        +     +                                +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |          A  A  +        +     +                                +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                            X                                             |             
      Clear Cell Focus                     |                                                          X               |             
      Clear Cell Focus, Multiple           |    X                                   X                                 |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |    2              2     2  2        2     2     2                        |             
      Hyperplasia                          |                            3           3     3           3               |             
      Infarct                              |                               3                                          |             
      Inflammation, Chronic Active, Diffuse|    1  1     1  1  1  1  1  1  1  2  2  1  1  2  1  2  1  1  2        1  1|             
      Pigmentation, Multifocal             |    2  3     2  2  2  3  2  2  2  3  3  1  2  3  2  3  2  2  2  2     2  2|             
      Vacuolization Cytoplasmic            |                                  3                                       |             
      Bile Duct, Hyperplasia, Multifocal   |       3           2  3  2     2  2  2  2     2     2        2            |             
      Hepatocyte, Cytomegaly, Diffuse      |    2  2     2  2  2  3  3  3  2  3  3  2  3  2  3  2  3  2  2  2     2  2|             
      Hepatocyte, Necrosis, Acute, Diffuse |    2  2     1  2  2     2  2  2  2  2  2  2  2  2  2  2  2  2  2     2  2|             
                                            __________________________________________________________________________|             
   Pancreas                                |          A  +  +        +     +                                +  A  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |          A  +  +        +     +                                +  A  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |          A  +  +        +     +                                +  A  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |          A  +  +        +     +                                +  A  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |          A  +  +        +     +                                +  A  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |          +  +  +        +     +     +                          +  +  +  +|             
      Degeneration, Chronic                |                               3                                          |             
      Mineralization                       |                                                                          |             
      Atrium, Thrombosis                   |                               X     X                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Capsule, Hyperplasia                 |       2        2  2  2  2  3           2     2     2  2  2  2  1     2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Degeneration, Fatty                  |                                                    2                     |             
      Hypertrophy                          |    2                 2     2                          2  2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 3| 5| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 3| 5| 3|             
                             DAY ON TEST   | 3| 2| 2| 2| 5| 8| 3| 0| 5| 3| 3| 2| 0| 2| 6| 3| 3| 3| 3| 3| 3| 2| 1| 7| 4|             
                                           | 6| 9| 9| 8| 0| 7| 1| 5| 6| 0| 8| 9| 8| 9| 4| 0| 1| 1| 0| 1| 0| 1| 5| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    100 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hyperplasia                          |       2                             1              2                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |          A  +  +        +     +                                +  A  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |          A  +  +        +     +                                +  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |          M  +  +        +     +                                +  A  +  +|             
      Pars Distalis, Cyst                  |                         X                                                |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |          A  +  +        +     +                                +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |          +  +  +  +     +     +                                +  A  +  +|             
      Granuloma Sperm                      |                   4                                                      |             
                                            __________________________________________________________________________|             
   Penis                                   |             +                                                            |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +                                                        +   |             
      Inflammation, Chronic Active         |                                                                      4   |             
                                            __________________________________________________________________________|             
   Prostate                                |          A  +  +        +     +                                +  A  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |             2                                                           3|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                +  +     +|             
      Dilatation                           |                                                                3  3      |             
      Inflammation, Chronic Active         |                                                                         4|             
                                            __________________________________________________________________________|             
   Testes                                  |          +  +  +        +     +                                +  A  +  +|             
      Germinal Epithelium, Degeneration    |             2                                                           2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Neutrophilia                         |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |          A  +  +        +     +                                +  A  +  +|             
      Femoral, Hyperplasia, Neutrophil     |                         4                                      3         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          A  M  +  +     +  +  +     +           +              +  M  +  +|             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                   3        3        3           2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |          A  M  +        +     +                                +  M  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  A  +  +        +  +  +              +                 +  M  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |       3        3        3  4  3              2                 3         |             
                                            __________________________________________________________________________|             
   Thymus                                  |          M  +  +        M     M                                M  A  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 3| 5| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 3| 5| 3|             
                             DAY ON TEST   | 3| 2| 2| 2| 5| 8| 3| 0| 5| 3| 3| 2| 0| 2| 6| 3| 3| 3| 3| 3| 3| 2| 1| 7| 4|             
                                           | 6| 9| 9| 8| 0| 7| 1| 5| 6| 0| 8| 9| 8| 9| 4| 0| 1| 1| 0| 1| 0| 1| 5| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    100 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |          M  M  M        M     M                                M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    |       +  A  +  +  +     +  +  +                          +  +  +  +  +  I|             
      Acanthosis                           |                                                                      3   |             
      Alopecia                             |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Ulcer                                |                            3                                4        3   |             
      Subcutaneous Tissue, Fibrosis        |                                                                2     3   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +  +  +     +  +  +  +           +  +  +     +  +  +  +  +  +  +|             
      Joint, Femur, Tibia, Hyperostosis    |                                                                          |             
      Joint, Tarsal, Hyperostosis          |                      X     X              X  X  X     X  X  X            |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                         +                                                |             
      Mineralization, Multifocal           |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |          A  +  +        +     +                                +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |          +  +  +        +     +                             +  +  +  +  +|             
      Interstitium, Inflammation, Acute    |                                                                          |             
      Interstitium, Mineralization         |                         2                                                |             
                                            __________________________________________________________________________|             
   Nose                                    |          +  +  +        +     +                                +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |          +  +  +        +     +                                +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          M  +  M        +     +                                +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |          A  +  +     +  +     +                                +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                         4|             
      Nephropathy, Chronic                 |                                                                      2   |             
      Pelvis, Inflammation, Acute          |             2                                                            |             
      Renal Tubule, Mineralization         |                                                                   2      |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |          A  +  +        +     +                                +  A  +  +|             
      Dilatation                           |                                                                      4   |             
      Inflammation, Acute                  |             4                                                            |             
      Inflammation, Chronic Active         |                                                                         3|             
      Mucosa, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 4| 7| 6| 7| 7| 7| 7| 6| 5| 7| 5| 7| 6| 7| 6| 3| 1| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 1| 8| 9| 0| 8| 3| 2| 2| 3| 2| 4| 3| 4| 3| 3| 3| 5| 3| 8| 3| 3| 2| 2| 9| 2|            |
                                           | 3| 9| 2| 4| 2| 1| 9| 9| 1| 6| 5| 0| 3| 1| 5| 1| 6| 6| 9| 1| 0| 9| 9| 3| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|      A     |
    100 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +                    +  +     +     +        +  +                  |  17        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +     A                    +  +     A     A        +  A                  |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +                    +  +     +     +        +  +                  |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +                    +  +     A     +        +  A                  |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +                    +  +     +     +        +  +                  |  15        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +                    +  +     +     +        +  A                  |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +                    +  +     A     +        +  +                  |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +                    +  +     A     +        +  A                  |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +                    +  +     A     +        +  +                  |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +                    +  +     A     +        +  +                  |  13        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Angiectasis                          |                            3                                             |      1  3.0|
      Basophilic Focus                     |                                                                          |      1     |
      Clear Cell Focus                     |                      X                 X                    X            |      4     |
      Clear Cell Focus, Multiple           |                   X     X        X                                X     X|      7     |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |    3     3              2  2     2     2     2  2        2  2  2  2     2|     20  2.1|
      Hyperplasia                          |                         3        3                                       |      6  3.0|
      Infarct                              |                                                          4               |      2  3.5|
      Inflammation, Chronic Active, Diffuse| 1  1  2  2  2  2  2  2  2  1     2     2  1  2  2        1  1  2  1  1  1|     42  1.4|
      Pigmentation, Multifocal             | 1  2  2  2  3  2  2  2  2  2     2  2  2  2  2  3  2     2  2  2  2  3  2|     45  2.2|
      Vacuolization Cytoplasmic            |          2                                                               |      2  2.5|
      Bile Duct, Hyperplasia, Multifocal   |    2        2     2  2  2        2     2     2  2              2  2      |     22  2.1|
      Hepatocyte, Cytomegaly, Diffuse      | 2  2  3  3  2  3  3  3  2  2  2  3  2  2  2  2  2  2  1  2  2  3  2  2  3|     47  2.3|
      Hepatocyte, Necrosis, Acute, Diffuse | 2  2  2  2  2  2  2  2  2  2     2  2  2  2     2        2  2  3     2  2|     41  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +                    +  +     +     +        +  +                  |  15        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +                    +  +     +     +        +  +                  |  15        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +     +                    +  +     A     +        +  +                  |  14        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +                    +  +     A     +        +  +                  |  14        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +                    +  +     A     +        +  +                  |  14        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +                    +  +     +     +        +  +                  |  18        |
      Degeneration, Chronic                |                                                                          |      1  3.0|
      Mineralization                       |                               2                                          |      1  2.0|
      Atrium, Thrombosis                   |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 4| 7| 6| 7| 7| 7| 7| 6| 5| 7| 5| 7| 6| 7| 6| 3| 1| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 1| 8| 9| 0| 8| 3| 2| 2| 3| 2| 4| 3| 4| 3| 3| 3| 5| 3| 8| 3| 3| 2| 2| 9| 2|            |
                                           | 3| 9| 2| 4| 2| 1| 9| 9| 1| 6| 5| 0| 3| 1| 5| 1| 6| 6| 9| 1| 0| 9| 9| 3| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|      A     |
    100 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Capsule, Hyperplasia                 | 2  2  1  2        2     2  2  2  2  2  1  2     2  2           2  2  2  2|     33  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Degeneration, Fatty                  |                                              2                           |      2  2.0|
      Hypertrophy                          |    1                 2                 3        2        2               |     10  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  I  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Hyperplasia                          |                      2           3              2              3  2  1  2|     10  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +                    +  +     +     +        +  +                  |  15        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M     +                    +  +     +     M        +  +                  |  12        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     I                    +  +     M     +        +  M                  |  12        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +                    +  +     +     +        +  +                  |  15        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +     +                    +  +     +     +        +  +                  |  17        |
      Granuloma Sperm                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Penis                                   | +           +                                         +              +   |   5        |
      Inflammation, Acute                  |                                                       3                  |      1  3.0|
      Inflammation, Chronic Active         |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                   +                             +  +                 +   |   6        |
      Inflammation, Chronic Active         |                                                 3  4                 3   |      4  3.5|
                                            __________________________________________________________________________|____________|
   Prostate                                | +     +                    +  +     +     +        +  +                  |  15        |
      Inflammation, Acute                  |                                                       2                  |      1  2.0|
      Inflammation, Chronic Active         | 3                                                  3                     |      4  2.8|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +                                                                        |   4        |
      Dilatation                           | 4                                                                        |      3  3.3|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +     +                    +  +     +     +        +  +  +               |  17        |
      Germinal Epithelium, Degeneration    |                                                          4               |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                   +      |   1        |
      Neutrophilia                         |                                                                   X      |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +                    +  +     +     +        +  +                  |  15        |
      Femoral, Hyperplasia, Neutrophil     |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +        +  +        +  +     +     +        +  +     +  +  +     +|  24        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 4| 7| 6| 7| 7| 7| 7| 6| 5| 7| 5| 7| 6| 7| 6| 3| 1| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 1| 8| 9| 0| 8| 3| 2| 2| 3| 2| 4| 3| 4| 3| 3| 3| 5| 3| 8| 3| 3| 2| 2| 9| 2|            |
                                           | 3| 9| 2| 4| 2| 1| 9| 9| 1| 6| 5| 0| 3| 1| 5| 1| 6| 6| 9| 1| 0| 9| 9| 3| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|      A     |
    100 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lumbar, Hyperplasia, Plasma Cell     |                                                    3                     |      1  3.0|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                2  3                       2                 3     3     3|     10  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +                    +  +           +           +                  |  12        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +              +  +     +     +  +     +  +           +      |  23        |
      Depletion Lymphoid                   |       2     2                       3                                    |      3  2.3|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           |    3     3                 4  3           3  3        3           4      |     15  3.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     M                    I  +     M     I        +  +                  |   7        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M     M                    M  M     M     M        M  M                  |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +                 +  +     +     +  +  +  +  +  +        +  +   |  27        |
      Acanthosis                           |                                                                          |      1  3.0|
      Alopecia                             |          X                                      X                        |      2     |
      Hyperkeratosis                       |                                                                      2   |      1  2.0|
      Ulcer                                |                                              4                    3      |      5  3.4|
      Subcutaneous Tissue, Fibrosis        |                                              3                    2      |      4  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +  +     +  I  +     +  +     +     +        +  +                  |  28        |
      Joint, Femur, Tibia, Hyperostosis    |                X                                                         |      1     |
      Joint, Tarsal, Hyperostosis          |          X     X     X     X                       X                     |     13     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Mineralization, Multifocal           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +                    +  +     +     +        +  +                  |  16        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +                    +  +     +     +        +  +                  |  18        |
      Interstitium, Inflammation, Acute    |                                                       2                  |      1  2.0|
      Interstitium, Mineralization         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +                    +  +     +     +        +  +                  |  17        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +                    +  +     +     +        +  +                  |  17        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +     +                    +  +     +     +        M  M                  |  12        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 4| 7| 6| 7| 7| 7| 7| 6| 5| 7| 5| 7| 6| 7| 6| 3| 1| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 1| 8| 9| 0| 8| 3| 2| 2| 3| 2| 4| 3| 4| 3| 3| 3| 5| 3| 8| 3| 3| 2| 2| 9| 2|            |
                                           | 3| 9| 2| 4| 2| 1| 9| 9| 1| 6| 5| 0| 3| 1| 5| 1| 6| 6| 9| 1| 0| 9| 9| 3| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|      A     |
    100 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +                    +  +     +     +  +     +  +                  |  18        |
      Inflammation, Acute                  |                                              4                           |      1  4.0|
      Inflammation, Chronic Active         | 3                                                                        |      2  3.5|
      Nephropathy, Chronic                 |                               2           2                              |      3  2.0|
      Pelvis, Inflammation, Acute          |                                                    2  3                  |      3  2.3|
      Renal Tubule, Mineralization         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 | +                                                     +                  |   2        |
      Calculus Micro Observation Only      | X                                                                        |      1     |
      Inflammation, Acute                  |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +                    +  +     +     +        +  A              +   |  15        |
      Dilatation                           |       3                    3                                             |      3  3.3|
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Inflammation, Chronic Active         | 4                                                                        |      2  3.5|
      Mucosa, Hyperplasia                  |                                                    3                     |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 7| 5| 4| 6| 7| 5| 5| 7| 1| 7| 5| 3| 2| 3| 3| 3| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 2| 8| 9| 2| 2| 9| 5| 0| 8| 8| 3| 4| 3| 7| 7| 9| 7| 7| 7| 4| 3| 3| 3| 2|             
                                           | 0| 9| 0| 0| 9| 8| 0| 6| 1| 2| 4| 1| 2| 0| 0| 6| 9| 6| 6| 6| 5| 0| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  A  A  +  M  A  A  +  A  A  +  +  +  A  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  A  A  M  +  M  A  +  +  M  A  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  +  A  +  +  A  +  +  +  A  +  A  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  A  +  M  A  A  +  A  A  +  +  +  M  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  A  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  A  A  M  +  M  +  +  M  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  A  A  M  +  A  A  +  +  +  A  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  A  A  M  +  A  A  +  +  +  A  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                                                                        |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |       X              X                                            X      |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      | 2  3                    2        2     2                 2  3  2  2  2  3|             
      Hyperplasia                          |                                           3                 3            |             
      Infarct                              |                         3                                                |             
      Inflammation, Chronic Active, Diffuse| 2  2  2  2  2  2     2  2  2  2  2     2  2  2  2  2  2  3  3  2  2  2  3|             
      Pigmentation, Multifocal             | 2  2  2  2  2  2     2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
      Bile Duct, Cyst, Multiple            |       X                                                                  |             
      Bile Duct, Dilatation, Focal         |                                                                      3   |             
      Bile Duct, Hyperplasia, Multifocal   | 3  2  2  3  3  2     2  2  2  3  2     2           2  2     3  2  2  2  2|             
      Hepatocyte, Cytomegaly, Diffuse      | 4  4  4  4  4  3  4  4  4  4  4  4  2  4  3  2  2  2  3  3  3  4  4  4  4|             
      Hepatocyte, Necrosis, Acute, Diffuse | 2  2  2  2  2  2     2  2  2  2  2  1  2  1  2  2  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                      +                           |             
      Inflammation, Chronic                |                                              2                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |       2                                                                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer, Chronic Active                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +|             
      Ulcer, Acute                         |                                              2                           |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                  +     +                                 |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic                         |                                  3     3                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 7| 5| 4| 6| 7| 5| 5| 7| 1| 7| 5| 3| 2| 3| 3| 3| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 2| 8| 9| 2| 2| 9| 5| 0| 8| 8| 3| 4| 3| 7| 7| 9| 7| 7| 7| 4| 3| 3| 3| 2|             
                                           | 0| 9| 0| 0| 9| 8| 0| 6| 1| 2| 4| 1| 2| 0| 0| 6| 9| 6| 6| 6| 5| 0| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Degeneration, Chronic                |                      3        2                                          |             
      Mineralization                       |                         2                                                |             
      Atrium, Thrombosis                   |          X              X                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 |       1              2     2  2              2  1  2  2  2  2        2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         2|             
      Hypertrophy                          |    2                                                                 2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2     2                                                        2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  M  +  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  A  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                 M                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +                                            +        +  +               |             
      Inflammation, Acute                  |                                              4        3  3               |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                              2     2     3               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                   +              +        +     +                        |             
      Dilatation                           |                   3              2              2                        |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
      Germinal Epithelium, Degeneration    |                      2                                3                  |             
      Germinal Epithelium, Mineralization  |                                  2                          2            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia, Neutrophil     |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 7| 5| 4| 6| 7| 5| 5| 7| 1| 7| 5| 3| 2| 3| 3| 3| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 2| 8| 9| 2| 2| 9| 5| 0| 8| 8| 3| 4| 3| 7| 7| 9| 7| 7| 7| 4| 3| 3| 3| 2|             
                                           | 0| 9| 0| 0| 9| 8| 0| 6| 1| 2| 4| 1| 2| 0| 0| 6| 9| 6| 6| 6| 5| 0| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Inguinal, Infiltration Cellular,     |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                         2        3                                2     2|             
      Mesenteric, Hyperplasia, Lymphoid    |       3                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |          2     3                                                         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                        2                                2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |             2  3     3  2  3  3     2                                    |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           | 3        3                             3  2                 4        3  2|             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  M  +  M  M  M  M  M  M  M  M  M  M  +  M  +  +  +  M  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Foreign Body, Focal                  |                   3                                                      |             
      Ulcer                                |                                        3                             4  4|             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                        3        2                        |             
      Subcutaneous Tissue, Lymphatic,      |                                                                          |             
          Dilatation                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Joint, Femur, Tibia, Hyperostosis    |                                                                          |             
      Joint, Tarsal, Hyperostosis          |    X        X                                                  X  X      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    | 3                                                                        |             
      Alveolar Epithelium, Hyperplasia     |                                                                         2|             
      Alveolus, Foreign Body               |                                              3     3  3  2               |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |          3                                                               |             
      Perivascular, Edema, Acute           | 3                       2                    2                           |             
      Perivascular, Edema, Chronic Active  |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 7| 5| 4| 6| 7| 5| 5| 7| 1| 7| 5| 3| 2| 3| 3| 3| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 2| 8| 9| 2| 2| 9| 5| 0| 8| 8| 3| 4| 3| 7| 7| 9| 7| 7| 7| 4| 3| 3| 3| 2|             
                                           | 0| 9| 0| 0| 9| 8| 0| 6| 1| 2| 4| 1| 2| 0| 0| 6| 9| 6| 6| 6| 5| 0| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     | +                                                                        |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                                 |             
      Atrophy, Diffuse                     |                                        4                                 |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  M  +  +  +  +|             
      Acinus, Dilatation                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
      Inflammation, Acute                  |                                     2        2           2               |             
      Inflammation, Chronic Active         |                                                    3                     |             
      Nephropathy, Chronic                 |             2  2           2     2        2                    2  2  2  2|             
      Cortex, Cyst                         |                                                                X         |             
      Renal Tubule, Mineralization         |                                                 2                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                     X                                    |             
      Dilatation                           |                                     3              3                     |             
      Inflammation, Chronic Active         |                                     3              3                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 5| 7| 5| 7| 4| 6| 7| 5| 7| 7| 7| 6| 4| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 4| 2| 3| 4| 3| 9| 3| 4| 9| 3| 1| 2| 3| 2| 5| 7| 4| 1| 3| 2| 3| 2| 3|            |
                                           | 0| 0| 0| 9| 1| 9| 0| 8| 1| 6| 0| 1| 2| 9| 0| 9| 4| 6| 4| 9| 1| 9| 6| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|      A     |
    200 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +     +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  A  +  A  A  +  A  +  +  +  A  A  +  A  +  +     +  +|  32        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  +     +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  M  +  A  +  +  +  +  A  +  A  +  +     +  +|  35        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  +     +  +|  41        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  A  +  +  M  +  M  +  +  +  +  A  +  A  +  +     +  +|  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  +     +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  A  +  A  +  +     +  +|  38        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  M  +  +  +  +  A  +  A  +  +     +  +|  37        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  A  +  A  +  +     +  +|  37        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +     +  +|  48        |
      Angiectasis                          | 2                                                                        |      2  2.0|
      Basophilic Focus                     |                                           X           X     X        X   |      4     |
      Clear Cell Focus                     | X        X                                                  X            |      6     |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      | 2  3     2  3  2  2        2  4        2  2  2        2     2  3     2  3|     27  2.3|
      Hyperplasia                          |          3                                3  3                           |      5  3.0|
      Infarct                              |                                                                          |      1  3.0|
      Inflammation, Chronic Active, Diffuse| 2  3  3  2  2  2  2  2  2  2  3  2  2  2  2  2  2  2  2     2  2     2  2|     46  2.1|
      Pigmentation, Multifocal             | 2  2  2  2  2  2  2  2  2  2     2  2  2  2  2  2  2  2     2  2     2  2|     46  2.0|
      Bile Duct, Cyst, Multiple            |                                                                          |      1     |
      Bile Duct, Dilatation, Focal         |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia, Multifocal   | 2  3  2  2  2  2  3     2        2     2  2  2  2     2     2  2     3  2|     37  2.2|
      Hepatocyte, Cytomegaly, Diffuse      | 4  4  3  4  4  3  4  3  4  2  3  4  4  4  4  4  3  4  4     4  4     4  4|     48  3.6|
      Hepatocyte, Necrosis, Acute, Diffuse | 2  2  2  2  2  2  2     2  2     2  2  2  2  2  2  2  2     2  2     2  2|     45  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  +     +  +|  44        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +     +  +|  48        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  +     +  +|  44        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  +     +  +|  43        |
      Acanthosis                           |             3     4                                                      |      2  3.5|
      Inflammation, Chronic Active         |             3     3                                                      |      2  3.0|
      Ulcer, Chronic Active                |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  +     +  +|  42        |
      Ulcer, Acute                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |       +                                                                  |   3        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 5| 7| 5| 7| 4| 6| 7| 5| 7| 7| 7| 6| 4| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 4| 2| 3| 4| 3| 9| 3| 4| 9| 3| 1| 2| 3| 2| 5| 7| 4| 1| 3| 2| 3| 2| 3|            |
                                           | 0| 0| 0| 9| 1| 9| 0| 8| 1| 6| 0| 1| 2| 9| 0| 9| 4| 6| 4| 9| 1| 9| 6| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|      A     |
    200 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic                         |       2                                                                  |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|  49        |
      Degeneration, Chronic                |                                                                          |      2  2.5|
      Mineralization                       |                                                                          |      1  2.0|
      Atrium, Thrombosis                   |                X                                                         |      3     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +     +  +|  46        |
      Capsule, Hyperplasia                 |    2  2  2     2  2        2  2     2  2  2           2     2  2     2  2|     27  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +     +  +|  46        |
      Hyperplasia                          |    2                                      2     2                        |      4  2.0|
      Hypertrophy                          |          2                             2     2                 2         |      6  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +     +  +|  45        |
      Hyperplasia                          |       2  2                    1     2     2                          3  2|     10  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  +     +  +|  44        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +     +  +|  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  M  +  +  +  +  A  +  +  M  +  +  +  +  +  +  +  +  M  +  +     +  +|  41        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +     +  +|  47        |
      Follicle, Cyst                       |                                                       X                  |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                        +                                 |   1        |
      Inflammation, Focal, Granulomatous   |                                        2                                 |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +     +  +|  47        |
      Inflammation, Chronic Active         |                                        4                                 |      1  4.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +                       +        +                    +                  |   8        |
      Inflammation, Acute                  |                         3        3                    3                  |      6  3.2|
      Duct, Dilatation                     |                                  4                                       |      1  4.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +     +  +|  45        |
      Inflammation, Acute                  |                                                    3                     |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |       +                                            +  +                  |   7        |
      Dilatation                           |       2                                            2  3                  |      6  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 5| 7| 5| 7| 4| 6| 7| 5| 7| 7| 7| 6| 4| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 4| 2| 3| 4| 3| 9| 3| 4| 9| 3| 1| 2| 3| 2| 5| 7| 4| 1| 3| 2| 3| 2| 3|            |
                                           | 0| 0| 0| 9| 1| 9| 0| 8| 1| 6| 0| 1| 2| 9| 0| 9| 4| 6| 4| 9| 1| 9| 6| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|      A     |
    200 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |                                                    2                     |      1  2.0|
      Inflammation, Chronic Active         |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +     +  +|  47        |
      Necrosis                             |                                        4                                 |      1  4.0|
      Germinal Epithelium, Degeneration    |                                                    2                     |      3  2.3|
      Germinal Epithelium, Mineralization  |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  M     +  +|  44        |
      Femoral, Hyperplasia, Neutrophil     |       3                    3                                             |      3  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  M  +  +     +  +|  44        |
      Inguinal, Infiltration Cellular,     |                                                                          |            |
           Plasma Cell                     |                            4                                             |      1  4.0|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |    3     2                             3        3           2  2         |     10  2.4|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  M  +  +     +  +|  43        |
      Depletion Lymphoid                   |                                                                          |      2  2.5|
      Hematopoietic Cell Proliferation     |                                        3                                 |      1  3.0|
      Hyperplasia, Lymphoid                |             2                                3                           |      4  2.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +     +  +|  46        |
      Depletion Lymphoid                   |                2                                2     2                  |     10  2.4|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           |       3     3           2  4  4  3  2  3     3        3              3   |     18  2.9|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  M  M  M  M  +  M  +  M  +  M  M  M  M  M  M  M  +  +     M  +|  18        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M     M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|  49        |
      Cyst Epithelial Inclusion            |                                        X                                 |      1     |
      Foreign Body, Focal                  |                                                                          |      1  3.0|
      Ulcer                                | 4     4                                               4                  |      6  3.8|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  | 3     3     2                                         4                  |      6  2.8|
      Subcutaneous Tissue, Lymphatic,      |                                                                          |            |
          Dilatation                       |                3                                                         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M     +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05073-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 5| 7| 5| 7| 4| 6| 7| 5| 7| 7| 7| 6| 4| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 4| 2| 3| 4| 3| 9| 3| 4| 9| 3| 1| 2| 3| 2| 5| 7| 4| 1| 3| 2| 3| 2| 3|            |
                                           | 0| 0| 0| 9| 1| 9| 0| 8| 1| 6| 0| 1| 2| 9| 0| 9| 4| 6| 4| 9| 1| 9| 6| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|      A     |
    200 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Joint, Femur, Tibia, Hyperostosis    | X                       X              X                                 |      3     |
      Joint, Tarsal, Hyperostosis          |    X                    X        X        X                             X|      9     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +     +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|  49        |
      Hemorrhage, Acute                    |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                2         |      2  2.0|
      Alveolus, Foreign Body               |                                                                          |      4  2.8|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active, Multifocal               |                                                                          |      1  3.0|
      Perivascular, Edema, Acute           |                2                                                         |      4  2.3|
      Perivascular, Edema, Chronic Active  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|  49        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +     +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Atrophy, Diffuse                     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +     +  +|  43        |
      Acinus, Dilatation                   |                                        3                                 |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +     +  +|  47        |
      Infiltration Cellular, Plasma Cell   |                            2                                             |      1  2.0|
      Inflammation, Acute                  |                                                    3                     |      4  2.3|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Nephropathy, Chronic                 | 2  2     2  2  3                 2  3  3     2              2  2     2  2|     22  2.1|
      Cortex, Cyst                         |                                                                          |      1     |
      Renal Tubule, Mineralization         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  +     +  +|  43        |
      Calculus Gross Observation           |                                                                          |      1     |
      Dilatation                           |                                                                          |      2  3.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
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