TR 349 Mouse Pathology Tables
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
Facility: Battelle Columbus Laboratory
Chemical CAS #: 87-86-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 3| 2| 3| 2| 5| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 2| 7| 2| 3| 3|
| 0| 9| 0| 0| 9| 0| 9| 3| 1| 0| 1| 9| 5| 1| 1| 9| 1| 0| 1| 0| 9| 4| 9| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + A + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A M + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X |
Degeneration, Cystic | 3 |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 1 2 2 2 2 2 2 2 2 |
Infarct | 2 2 |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + A + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 4 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + A + + + + + + + + + + + +|
Acanthosis | 3 3 3 |
Inflammation, Chronic Active | 2 2 2 |
Ulcer, Acute | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + A + + + + + + + + + + + +|
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 2 2 2 2 3 3 2 2 3 3 3 3 2 2 3 2 2 3 3 2 2 2 3 2 3|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + M + + + + + + + + + M + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 3| 2| 3| 2| 5| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 2| 7| 2| 3| 3|
| 0| 9| 0| 0| 9| 0| 9| 3| 1| 0| 1| 9| 5| 1| 1| 9| 1| 0| 1| 0| 9| 4| 9| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + M + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 3 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 4 3 2 |
Follicular Cell, Hyperplasia | 2 2 2 3 3 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + M + + + I + + + + + + A + + + + + + + + + + + +|
Follicle, Cyst | X X X X X X|
Periovarian Tissue, Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Endometrium, Hyperplasia, Cystic, | |
Glandular, Multifocal | 3 3 3 3 3 3 4 3 3 3 3 3 2 3 2 3 3 3 2 2 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric, Hematopoietic Cell | |
Proliferation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + M M M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + + M + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 3 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Ulcer | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 3| 2| 3| 2| 5| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 2| 7| 2| 3| 3|
| 0| 9| 0| 0| 9| 0| 9| 3| 1| 0| 1| 9| 5| 1| 1| 9| 1| 0| 1| 0| 9| 4| 9| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Infiltration Cellular, | |
Lymphocyte | 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Foreign Body | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + M + + + + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 1 1 1 4 1 1 2 1 1 1|
Glomerulus, Amyloid Deposition | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 1| 7| 7| | |
DAY ON TEST | 2| 3| 2| 0| 2| 3| 3| 8| 3| 3| | |
| 9| 1| 9| 5| 9| 0| 5| 3| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + A M + + | 33 |
__________________________________________________________________________|____________|
Gallbladder | + + A A + + A A + + | 29 |
__________________________________________________________________________|____________|
Intestine Large | + + A + + + M + + + | 32 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + M + + + | 30 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + M + + + | 32 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + M + + + | 31 |
__________________________________________________________________________|____________|
Intestine Small | + + A + + + M + + + | 32 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + M + + + | 32 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + M + + + | 31 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + M + + + | 32 |
__________________________________________________________________________|____________|
Liver | + + A + + + A + + + | 33 |
Basophilic Focus | | 1 |
Clear Cell Focus | | 1 |
Degeneration, Cystic | | 1 3.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 2 2 2 | 14 1.9|
Infarct | 2 2 | 4 2.0|
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + A I + + M + + + | 31 |
Acinus, Atrophy | | 4 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + A + + + + M + + | 33 |
__________________________________________________________________________|____________|
Stomach | + + A + + + M + + + | 32 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + A + + + M + + + | 32 |
Acanthosis | 4 | 4 3.3|
Inflammation, Chronic Active | | 3 2.0|
Ulcer, Acute | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + + M + + + | 32 |
Dysplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 35 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + M + + + | 34 |
Capsule, Hyperplasia | 3 3 1 3 3 2 3 3 | 33 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + A + + + M + + + | 33 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 1| 7| 7| | |
DAY ON TEST | 2| 3| 2| 0| 2| 3| 3| 8| 3| 3| | |
| 9| 1| 9| 5| 9| 0| 5| 3| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + A + + + M + + + | 33 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + A I + + M + + + | 31 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M M + + | 30 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + + | 32 |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 3 2 3 3 | 10 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + M M + + | 33 |
Inflammation, Chronic | | 3 3.0|
Follicular Cell, Hyperplasia | 3 | 7 2.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + A + + + M + + + | 30 |
Follicle, Cyst | X X | 8 |
Periovarian Tissue, Cyst | | 2 |
__________________________________________________________________________|____________|
Uterus | + + A + + + M + + + | 33 |
Inflammation, Chronic Active | | 1 3.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular, Multifocal | 3 3 4 2 3 4 | 28 2.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 35 |
Femoral, Myelofibrosis | 2 2 | 8 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + M + + + + M + + | 33 |
Mesenteric, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + M + + | 33 |
Depletion Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + A + + + A + + + | 33 |
Depletion Lymphoid | 2 | 2 2.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | 3 | 2 3.5|
__________________________________________________________________________|____________|
Thymus | + + M + + + + M M + | 28 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 1| 7| 7| | |
DAY ON TEST | 2| 3| 2| 0| 2| 3| 3| 8| 3| 3| | |
| 9| 1| 9| 5| 9| 0| 5| 3| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + A + + + M M + + | 30 |
Hyperplasia, Cystic | 2 2 2 | 7 2.4|
__________________________________________________________________________|____________|
Skin | + + A + + + A + + + | 33 |
Acanthosis | 3 | 1 3.0|
Ulcer | 3 | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 35 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + A + + + A + + + | 33 |
Meninges, Infiltration Cellular, | | |
Lymphocyte | | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 35 |
Lumen, Foreign Body | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + A M + + | 33 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + A + + + + + + + | 32 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + A + + + A + + + | 33 |
Nephropathy, Chronic | 1 2 | 13 1.4|
Glomerulus, Amyloid Deposition | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + M + + + | 32 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 2| 2| 2| 3| 2| 3| 3| 5| 3| 3| 3| 2| 3| 3|
| 9| 0| 1| 0| 1| 9| 0| 1| 5| 0| 0| 9| 9| 9| 1| 9| 0| 1| 6| 0| 1| 0| 9| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
100 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | |
__________________________________________________________________________|
Gallbladder | |
__________________________________________________________________________|
Intestine Large | |
__________________________________________________________________________|
Intestine Large, Cecum | |
__________________________________________________________________________|
Intestine Large, Colon | |
__________________________________________________________________________|
Intestine Large, Rectum | |
__________________________________________________________________________|
Intestine Small | + |
__________________________________________________________________________|
Intestine Small, Duodenum | |
__________________________________________________________________________|
Intestine Small, Ileum | + |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
__________________________________________________________________________|
Liver | + + + + + + + + A + + + + + + + + + + + + + + + +|
Clear Cell Focus | X X X|
Degeneration, Cystic | 4 |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 2 2 |
Infarct | |
Inflammation, Chronic Active, Diffuse| 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 2 2|
Pigmentation, Multifocal | 2 2 1 1 2 2 2 1 1 2 2 1 2 2 2 2 2 2 3 2|
Vacuolization Cytoplasmic | 3 2|
Bile Duct, Hyperplasia, Multifocal | 4 |
Bile Duct, Inflammation, Chronic | |
Active, Multifocal | 4 |
Hepatocyte, Cytomegaly, Diffuse | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2|
Hepatocyte, Necrosis, Acute, Diffuse | 2 2 2 2 2 2 2 2 2 1 2 2 2 2 1 1 1 1 2 1 2 2|
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + |
__________________________________________________________________________|
Salivary Glands | |
__________________________________________________________________________|
Stomach | |
__________________________________________________________________________|
Stomach, Forestomach | |
__________________________________________________________________________|
Stomach, Glandular | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + A + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 3 2 2 3 3 2 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + A + + + + + + + + + + + + + + + +|
Atrophy | |
Degeneration, Fatty | 3 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 2 |
Hypertrophy | 3 3|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + A + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 2| 2| 2| 3| 2| 3| 3| 5| 3| 3| 3| 2| 3| 3|
| 9| 0| 1| 0| 1| 9| 0| 1| 5| 0| 0| 9| 9| 9| 1| 9| 0| 1| 6| 0| 1| 0| 9| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
100 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 2 2|
__________________________________________________________________________|
Islets, Pancreatic | |
__________________________________________________________________________|
Parathyroid Gland | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 3 3 |
__________________________________________________________________________|
Thyroid Gland | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + I + + + + |
Inflammation, Chronic Active | 4 |
Mineralization | |
Follicle, Cyst | X X X X X |
Periovarian Tissue, Cyst | X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic, | |
Glandular, Multifocal | 2 3 3 4 3 3 3 4 3 3 3 3 3 3 3 3 3 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | |
Femoral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + |
Mesenteric, Hematopoietic Cell | |
Proliferation | 4 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | |
__________________________________________________________________________|
Spleen | + + + + |
Depletion Lymphoid | |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 4 3 |
__________________________________________________________________________|
Thymus | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + |
__________________________________________________________________________|
Skin | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 2| 2| 2| 3| 2| 3| 3| 5| 3| 3| 3| 2| 3| 3|
| 9| 0| 1| 0| 1| 9| 0| 1| 5| 0| 0| 9| 9| 9| 1| 9| 0| 1| 6| 0| 1| 0| 9| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
100 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + |
__________________________________________________________________________|
Nose | |
__________________________________________________________________________|
Trachea | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | |
Inflammation, Chronic Active, | |
Multifocal | |
Renal Tubule, Cytoplasmic Alteration,| |
Diffuse | |
__________________________________________________________________________|
Urinary Bladder | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| |
DAY ON TEST | 2| 2| 3| 3| 2| 3| 9| 3| 2| 8| 3| 2| 3| 2| 3| 0| 3| 2| 3| 0| 3| 5| 3| 3| 7| |
| 9| 4| 0| 0| 9| 1| 2| 1| 9| 2| 1| 9| 1| 9| 0| 5| 1| 9| 1| 7| 1| 3| 0| 0| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
100 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + +| 4 |
__________________________________________________________________________|____________|
Gallbladder | A A M A| |
__________________________________________________________________________|____________|
Intestine Large | A + + +| 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + A| 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + +| 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + M +| 2 |
__________________________________________________________________________|____________|
Intestine Small | A + + + +| 5 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + +| 3 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A A M A| 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + +| 5 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Clear Cell Focus | | 3 |
Degeneration, Cystic | | 1 4.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 2 2 2 2 | 8 2.0|
Infarct | 4 2 | 2 3.0|
Inflammation, Chronic Active, Diffuse| 2 2 1 2 1 2 1 2 1 1 2 1 2 2 1| 34 1.4|
Pigmentation, Multifocal | 1 3 2 2 1 2 2 2 2 2 2 2 1 2 1 2 2| 37 1.8|
Vacuolization Cytoplasmic | 3 | 3 2.7|
Bile Duct, Hyperplasia, Multifocal | | 1 4.0|
Bile Duct, Inflammation, Chronic | | |
Active, Multifocal | | 1 4.0|
Hepatocyte, Cytomegaly, Diffuse | 1 2 2 1 2 1 1 2 1 1 2 2 2 2 2 2 2 2 2 2 1 2 2 1| 48 1.9|
Hepatocyte, Necrosis, Acute, Diffuse | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 1 1 2 2 2| 44 1.5|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | A + + +| 4 |
__________________________________________________________________________|____________|
Salivary Glands | + + + +| 4 |
__________________________________________________________________________|____________|
Stomach | A + + +| 3 |
__________________________________________________________________________|____________|
Stomach, Forestomach | A + + +| 3 |
__________________________________________________________________________|____________|
Stomach, Glandular | A + + +| 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + +| 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
Capsule, Hyperplasia | 3 2 3 2 3 3 2 3 2 3 2 2 2 2 3 2 2 2 2 3 2 3 3 2| 48 2.6|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
Atrophy | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| |
DAY ON TEST | 2| 2| 3| 3| 2| 3| 9| 3| 2| 8| 3| 2| 3| 2| 3| 0| 3| 2| 3| 0| 3| 5| 3| 3| 7| |
| 9| 4| 0| 0| 9| 1| 2| 1| 9| 2| 1| 9| 1| 9| 0| 5| 1| 9| 1| 7| 1| 3| 0| 0| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
100 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Degeneration, Fatty | | 1 3.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia | 2 | 2 2.0|
Hypertrophy | | 2 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | A + + +| 3 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + +| 4 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + M + + +| 14 |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 3 2 | 4 2.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + +| 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + +| 23 |
Inflammation, Chronic Active | | 1 4.0|
Mineralization | 3 | 1 3.0|
Follicle, Cyst | X X X X | 9 |
Periovarian Tissue, Cyst | X X X X X| 10 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + +| 37 |
Endometrium, Hyperplasia, Cystic, | | |
Glandular, Multifocal | 3 3 3 3 3 4 3 3 3 3 3 4 3 3 2 3 4| 35 3.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + +| 4 |
Femoral, Myelofibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + +| 12 |
Mesenteric, Hematopoietic Cell | | |
Proliferation | 2 | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + +| 4 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + +| 13 |
Depletion Lymphoid | 3| 1 3.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | 3 4 | 4 3.5|
__________________________________________________________________________|____________|
Thymus | M + M + M| 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| |
DAY ON TEST | 2| 2| 3| 3| 2| 3| 9| 3| 2| 8| 3| 2| 3| 2| 3| 0| 3| 2| 3| 0| 3| 5| 3| 3| 7| |
| 9| 4| 0| 0| 9| 1| 2| 1| 9| 2| 1| 9| 1| 9| 0| 5| 1| 9| 1| 7| 1| 3| 0| 0| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
100 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + M| 3 |
__________________________________________________________________________|____________|
Skin | + + + + +| 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + +| 4 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + A + + +| 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + +| 5 |
__________________________________________________________________________|____________|
Nose | + + + +| 4 |
__________________________________________________________________________|____________|
Trachea | + + + +| 4 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + +| 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + +| 7 |
Inflammation, Chronic Active, | | |
Multifocal | 3 | 1 3.0|
Renal Tubule, Cytoplasmic Alteration,| | |
Diffuse | 2| 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | A + + +| 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 2| 1| 7| 1| 3| 3| 3| 3| 3| 9| 8| 3| 2| 9| 2| 3| 1| 2| 2| 3| 3| 9| 3|
| 4| 1| 9| 0| 3| 8| 0| 0| 1| 0| 1| 5| 2| 0| 9| 4| 9| 0| 1| 9| 9| 1| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
200 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + + + A + + + + + A A + + + + M A + + + + + +|
__________________________________________________________________________|
Intestine Large | A + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + A + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + A + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + A + + + + + + + + + + + + +|
Mineralization | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Clear Cell Focus | X X X X X |
Clear Cell Focus, Multiple | X X X X X |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 |
Hyperplasia | 3 3 3 |
Infarct | 4 4 |
Inflammation, Chronic Active, Diffuse| 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2|
Pigmentation, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Bile Duct, Hyperplasia, Multifocal | 2 2 |
Hepatocyte, Cytomegaly, Diffuse | 3 3 2 2 2 2 3 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3|
Hepatocyte, Necrosis, Acute, Diffuse | 2 2 1 4 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Pancreas | M + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 4|
Acinus, Inflammation, Chronic | |
Duct, Cyst | X|
__________________________________________________________________________|
Salivary Glands | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Stomach | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | A + + + + + + + + + + + + + + + + + + + + + M + +|
Acanthosis | 3 |
Erosion | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 |
Perivascular, Inflammation, Chronic | |
Active | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 2| 1| 7| 1| 3| 3| 3| 3| 3| 9| 8| 3| 2| 9| 2| 3| 1| 2| 2| 3| 3| 9| 3|
| 4| 1| 9| 0| 3| 8| 0| 0| 1| 0| 1| 5| 2| 0| 9| 4| 9| 0| 1| 9| 9| 1| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
200 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 3 3 3 3 3 3 2 3 2 3 2 2 3 2 3 3 3 2 3 3 3 3 3 3|
__________________________________________________________________________|
Adrenal Gland, Cortex | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Hyperplasia | 2 2 |
Hypertrophy | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M + M M + + + + + + + + + + + + + M + M M + + +|
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + M + + + + I + + + + + + M + M + M|
Pars Distalis, Hyperplasia | 2 2 2 3 |
__________________________________________________________________________|
Thyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | A + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Inflammation, Chronic Active | 4 |
Follicle, Cyst | X X X X X X X X |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | A + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic, | |
Glandular, Multifocal | 4 3 3 3 3 3 2 3 3 2 3 2 3 3 3 2 4 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Leukocytosis | |
Neutrophilia | X |
__________________________________________________________________________|
Bone Marrow | A + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Neutrophil | 4 |
Femoral, Myelofibrosis | 2 2 3 2 2 3 2 2|
Sternal, Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + M + + + + + + + + + + + + + + + + + + + + +|
Mesenteric, Hematopoietic Cell | |
Proliferation | |
Mesenteric, Hemorrhage | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + M + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 2| 1| 7| 1| 3| 3| 3| 3| 3| 9| 8| 3| 2| 9| 2| 3| 1| 2| 2| 3| 3| 9| 3|
| 4| 1| 9| 0| 3| 8| 0| 0| 1| 0| 1| 5| 2| 0| 9| 4| 9| 0| 1| 9| 9| 1| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
200 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia | |
__________________________________________________________________________|
Spleen | A + + + + A + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hematocyst | X |
Hyperplasia, Lymphoid | |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 3 3 4 3 2 |
__________________________________________________________________________|
Thymus | M M + M M M + + + + + M M + + + M M + + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M + M M + + + + M + + M + + + + + + + + +|
Hyperplasia, Cystic | 2 2 3 2 3 3 2 3 2 2 3 2|
__________________________________________________________________________|
Skin | A + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | A + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 |
Meninges, Infiltration Cellular, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Alveolar Epithelium, Hyperplasia | 2 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | |
__________________________________________________________________________|
Nose | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | M + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | A + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Metaplasia, Osseous | 2 2 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 2| 1| 7| 1| 3| 3| 3| 3| 3| 9| 8| 3| 2| 9| 2| 3| 1| 2| 2| 3| 3| 9| 3|
| 4| 1| 9| 0| 3| 8| 0| 0| 1| 0| 1| 5| 2| 0| 9| 4| 9| 0| 1| 9| 9| 1| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
200 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy, Chronic | 2 1 4 1 1 |
Renal Tubule, Cytoplasmic Alteration,| |
Diffuse | |
Renal Tubule, Necrosis, Acute | |
__________________________________________________________________________|
Urinary Bladder | A + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 2| 7| 6| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 2| 2| 3| 7| 2| 2| 6| 3| 3| 2| 3| 3| 2| 1| 5| 8| 3| 4| 5| 3| 2| 2| |
| 1| 1| 1| 9| 9| 0| 5| 4| 9| 1| 0| 1| 9| 0| 0| 9| 3| 6| 1| 0| 7| 8| 1| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
200 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + M + + + + + + + + + + + + + + + M + + + + + +| 47 |
__________________________________________________________________________|____________|
Gallbladder | + + A + + + + A + + + + + + + + A A + + + A + + +| 39 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + M + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + M + + + + + + + + A + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + M + + + + + + + + + + + + + + + + +| 47 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + M + + + + + + + + A + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + M + + + + + + + + + + + + + + + + +| 47 |
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + M + + + + + + + + A + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + M + + + + + + + + A + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X | 5 |
Clear Cell Focus | X X | 7 |
Clear Cell Focus, Multiple | X X X X X | 10 |
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 33 2.0|
Hyperplasia | | 3 3.0|
Infarct | | 2 4.0|
Inflammation, Chronic Active, Diffuse| 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 1 3 2 2 2| 44 2.0|
Pigmentation, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 47 2.0|
Bile Duct, Hyperplasia, Multifocal | | 2 2.0|
Hepatocyte, Cytomegaly, Diffuse | 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 48 2.9|
Hepatocyte, Necrosis, Acute, Diffuse | 2 2 2 2 2 2 3 2 2 2 3 2 3 2 3 2 2 2 2 2 2 2 2 2| 47 2.1|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
Acinus, Atrophy | 2 4 2 2 2 | 6 2.7|
Acinus, Inflammation, Chronic | 2 | 1 2.0|
Duct, Cyst | X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + M + + M + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + M + + + + + + + + A + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + M + + + + + + + + A + + + + + + + +| 46 |
Acanthosis | 2 3 | 3 2.7|
Erosion | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + M + + + + + + + + A + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 2| 7| 6| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 2| 2| 3| 7| 2| 2| 6| 3| 3| 2| 3| 3| 2| 1| 5| 8| 3| 4| 5| 3| 2| 2| |
| 1| 1| 1| 9| 9| 0| 5| 4| 9| 1| 0| 1| 9| 0| 0| 9| 3| 6| 1| 0| 7| 8| 1| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
200 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 3.0|
Perivascular, Inflammation, Chronic | | |
Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Capsule, Hyperplasia | 3 2 2 2 3 2 2 2 3 2 3 2 2 3 3 3 2 2 3 3 3 3 3 3 3| 49 2.7|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 | 2 2.5|
Hyperplasia | 2 | 3 2.0|
Hypertrophy | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + M + + M + M + + M + + M M + + + + M + + +| 35 |
__________________________________________________________________________|____________|
Pituitary Gland | M M + + + + + + M M + + + + + + + + + + M + + + +| 39 |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 | 10 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Angiectasis | | 1 3.0|
Inflammation, Chronic Active | | 1 4.0|
Follicle, Cyst | X X X X X X X | 15 |
Periovarian Tissue, Cyst | X X X | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
Endometrium, Hyperplasia, Cystic, | | |
Glandular, Multifocal | 2 3 3 3 4 3 3 3 2 2 3 3 2 2 2 3 3| 35 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 2 |
Leukocytosis | X | 1 |
Neutrophilia | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 2| 7| 6| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 2| 2| 3| 7| 2| 2| 6| 3| 3| 2| 3| 3| 2| 1| 5| 8| 3| 4| 5| 3| 2| 2| |
| 1| 1| 1| 9| 9| 0| 5| 4| 9| 1| 0| 1| 9| 0| 0| 9| 3| 6| 1| 0| 7| 8| 1| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
200 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Femoral, Hyperplasia, Neutrophil | 3 | 2 3.5|
Femoral, Myelofibrosis | 2 2 2 3 2 2 2| 15 2.2|
Sternal, Myelofibrosis | 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + M + + M + M + + + + + + + + + + + + + + + + +| 46 |
Mesenteric, Hematopoietic Cell | | |
Proliferation | 3 3 | 2 3.0|
Mesenteric, Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + M + M + + + + + + + + + + + + + + + + +| 45 |
Angiectasis | | 1 3.0|
Hyperplasia, Lymphoid | 2 2 | 3 2.0|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + A + + + + + + + + + + + + + + + + +| 47 |
Atrophy | | 1 3.0|
Hematocyst | | 1 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | 4 4 4 4 3 4 | 11 3.5|
__________________________________________________________________________|____________|
Thymus | + M M + + M + M + + + + + M + + + M M + + + + + +| 33 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + M + M + + M + M + M + + + + + + + M| 34 |
Hyperplasia, Cystic | 2 3 2 2 2 2 3 2 | 20 2.4|
__________________________________________________________________________|____________|
Skin | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
Ulcer | 4 | 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + I + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Compression | 4 | 2 4.0|
Meninges, Infiltration Cellular, | | |
Lymphocyte | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 2| 7| 6| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 2| 2| 3| 7| 2| 2| 6| 3| 3| 2| 3| 3| 2| 1| 5| 8| 3| 4| 5| 3| 2| 2| |
| 1| 1| 1| 9| 9| 0| 5| 4| 9| 1| 0| 1| 9| 0| 0| 9| 3| 6| 1| 0| 7| 8| 1| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
200 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia | 2 | 2 2.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Trachea | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 3 2 | 2 2.5|
Metaplasia, Osseous | | 2 2.0|
Nephropathy, Chronic | 2 2 1 2 2 2 2 2 | 13 1.8|
Renal Tubule, Cytoplasmic Alteration,| | |
Diffuse | 3 | 1 3.0|
Renal Tubule, Necrosis, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + A + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 4| 1| 7| 4| 1| 6| 4| 7| 7| 3| 5| 1| 5| 7| 2| 3| 4| 2| 3| 7|
DAY ON TEST | 3| 3| 2| 9| 2| 2| 8| 3| 2| 2| 7| 1| 3| 3| 3| 9| 0| 5| 3| 8| 6| 7| 6| 4| 3|
| 1| 1| 9| 8| 9| 7| 7| 1| 6| 6| 9| 7| 0| 0| 0| 8| 2| 2| 0| 6| 3| 5| 5| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + A + + + + + + M M +|
__________________________________________________________________________|
Gallbladder | + + + A + + M + + A A A + + + A A A + A + + A M +|
__________________________________________________________________________|
Intestine Large | + + + + + + A + + + + + + + + A + A + A + + A A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + M A + + A + + + + + A M A + A + + A A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + A A A + A + + A A +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + A + + + + + A M A + A + + A A +|
__________________________________________________________________________|
Intestine Small | + + + + + + A + + A + + + + + A + A + A + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + M A + + A + + + + + A A A + A + + A M +|
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + M A + + A + + + + M A M A + A + + A A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + A + + + + + A M A + A + + A A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + A + + + + + + A M +|
Basophilic Focus | X X |
Fibrosis | 2 |
Hematopoietic Cell Proliferation, | |
Multifocal | 1 |
Infarct | 3 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + A + + + + + + + + A M A + A + + M M +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + A + + + + + + M M +|
Inflammation, Acute | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + A + A + A + + + M +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + A + A + A + + + M +|
Cyst | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + A + A + A + + + M +|
Hyperplasia | |
Necrosis | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + A + + + + + + + M +|
Degeneration, Chronic | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + A A A + + + + + M +|
Capsule, Hyperplasia | 2 2 2 1 1 2 1 2 2 2 3 2 1 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + A A A + + + + + M +|
Hypertrophy | 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + A A A + + + + + M +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + A + + + + + + + + A M A + A + + A M +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + I M + + + M + A M M + + M + M M +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 4| 1| 7| 4| 1| 6| 4| 7| 7| 3| 5| 1| 5| 7| 2| 3| 4| 2| 3| 7|
DAY ON TEST | 3| 3| 2| 9| 2| 2| 8| 3| 2| 2| 7| 1| 3| 3| 3| 9| 0| 5| 3| 8| 6| 7| 6| 4| 3|
| 1| 1| 9| 8| 9| 7| 7| 1| 6| 6| 9| 7| 0| 0| 0| 8| 2| 2| 0| 6| 3| 5| 5| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + A A M + M + + M M +|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + M + + + + + A + + + + + + M M +|
Follicular Cell, Hyperplasia | 2 2 |
Follicular Cell, Hypertrophy | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + A + + + + + + + + +|
Inflammation, Acute | 2 |
__________________________________________________________________________|
Penis | + + |
__________________________________________________________________________|
Preputial Gland | + + + + + |
Inflammation, Chronic Active | 4 4 3 |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + A + + + + + + + + +|
Inflammation, Acute | 4 2 2 2 3 |
Inflammation, Chronic Active | 3 3 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + |
Dilatation | 2 3 2 2 |
Inflammation, Chronic Active | 4 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + A + + + + + + + + +|
Inflammation, Acute | 2 |
Germinal Epithelium, Degeneration | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Neutrophilia | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + A + A + A + + + A +|
Femoral, Hyperplasia, Neutrophil | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + M + + + + + A M A + A + + M M +|
Mesenteric, Hematopoietic Cell | |
Proliferation | 3 4 |
Renal, Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + A M A + A + + M M +|
Depletion Lymphoid | 2 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + A M A + + + + A M +|
Depletion Lymphoid | 2 3 3 3 3 2|
Lymphoid Follicle, Necrosis | 2 |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 3 3 3 |
__________________________________________________________________________|
Thymus | + + + M + + M M + + M + M M + M M M + M M + M M +|
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 4| 1| 7| 4| 1| 6| 4| 7| 7| 3| 5| 1| 5| 7| 2| 3| 4| 2| 3| 7|
DAY ON TEST | 3| 3| 2| 9| 2| 2| 8| 3| 2| 2| 7| 1| 3| 3| 3| 9| 0| 5| 3| 8| 6| 7| 6| 4| 3|
| 1| 1| 9| 8| 9| 7| 7| 1| 6| 6| 9| 7| 0| 0| 0| 8| 2| 2| 0| 6| 3| 5| 5| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + A A +|
Acanthosis | 3 |
Ulcer | 3 2 3 |
Subcutaneous Tissue, Inflammation, | |
Acute | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 3 2 3 3 3|
Subcutaneous Tissue, Metaplasia, | |
Osseous | 2 |
Subcutaneous Tissue, Lymphatic, | |
Dilatation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Joint, Tarsal, Hyperostosis | X X X X X X X|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + A A A + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + A + + + + + + + M +|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + M + + + + + A + + + + + + M M +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy, Diffuse | |
Lens, Cataract | 3 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + M M + + + + + + + + A + + + + + + M A +|
Hyperplasia, Cystic | 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + A + + + + + + + A +|
Inflammation, Acute | 4 |
Inflammation, Chronic Active | 2 |
Metaplasia, Osseous | 1 |
Nephropathy, Chronic | 1 2 1 2 1 2 2 2 |
Pelvis, Inflammation, Acute | 2 |
Pelvis, Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 4| 1| 7| 4| 1| 6| 4| 7| 7| 3| 5| 1| 5| 7| 2| 3| 4| 2| 3| 7|
DAY ON TEST | 3| 3| 2| 9| 2| 2| 8| 3| 2| 2| 7| 1| 3| 3| 3| 9| 0| 5| 3| 8| 6| 7| 6| 4| 3|
| 1| 1| 9| 8| 9| 7| 7| 1| 6| 6| 9| 7| 0| 0| 0| 8| 2| 2| 0| 6| 3| 5| 5| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Dilatation | 3 3 |
Renal Tubule, Necrosis | 2 |
__________________________________________________________________________|
Urethra | + + + + + |
Calculus Micro Observation Only | X X |
Concretion | 3 |
Inflammation, Acute | 3 3 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + A + + + + + + + + +|
Calculus Micro Observation Only | |
Concretion | 3 |
Dilatation | 3 3 3 3 3 |
Inflammation, Acute | 2 2 2 2 |
Inflammation, Chronic Active | 3 |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 5| 4| 5| 6| 6| 7| | |
DAY ON TEST | 4| 7| 3| 3| 4| 2| 1| 0| 7| 3| | |
| 4| 8| 1| 1| 2| 7| 0| 4| 5| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 32 |
__________________________________________________________________________|____________|
Gallbladder | + + + M + A A A + + | 20 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 29 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A A + + + | 24 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + M + + + | 27 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A M + + + | 25 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 29 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A A + + + | 24 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A M + + + | 23 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + | 26 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 32 |
Basophilic Focus | | 2 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 4 | 2 2.5|
Infarct | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + A + + + | 27 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 32 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 31 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 31 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 31 |
Hyperplasia | 3 | 1 3.0|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 33 |
Degeneration, Chronic | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 31 |
Capsule, Hyperplasia | 2 2 2 2 2 1 2 2 3 | 27 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 31 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 5| 4| 5| 6| 6| 7| | |
DAY ON TEST | 4| 7| 3| 3| 4| 2| 1| 0| 7| 3| | |
| 4| 8| 1| 1| 2| 7| 0| 4| 5| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hypertrophy | 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 31 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + A + + + | 27 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + M + + + + | 24 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 29 |
Pars Distalis, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 31 |
Follicular Cell, Hyperplasia | 2 | 3 2.0|
Follicular Cell, Hypertrophy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 34 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Penis | | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + | 6 |
Inflammation, Chronic Active | | 3 3.7|
Duct, Dilatation | 4 | 2 3.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 34 |
Inflammation, Acute | 3 | 6 2.7|
Inflammation, Chronic Active | | 3 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 7 |
Dilatation | 2 | 5 2.2|
Inflammation, Chronic Active | | 2 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 34 |
Inflammation, Acute | | 1 2.0|
Germinal Epithelium, Degeneration | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + | 2 |
Neutrophilia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Bone Marrow | A + + + + + + + + + | 30 |
Femoral, Hyperplasia, Neutrophil | 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + M + + + + + + + + | 27 |
Mesenteric, Hematopoietic Cell | | |
Proliferation | 3 2 2 | 5 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 5| 4| 5| 6| 6| 7| | |
DAY ON TEST | 4| 7| 3| 3| 4| 2| 1| 0| 7| 3| | |
| 4| 8| 1| 1| 2| 7| 0| 4| 5| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + | 27 |
Depletion Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 30 |
Depletion Lymphoid | 3 3 | 8 2.8|
Lymphoid Follicle, Necrosis | 2 | 2 2.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | 4 4 | 5 3.4|
__________________________________________________________________________|____________|
Thymus | + M + M + M M M + | 16 |
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 33 |
Acanthosis | | 1 3.0|
Ulcer | | 3 2.7|
Subcutaneous Tissue, Inflammation, | | |
Acute | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 5 2.8|
Subcutaneous Tissue, Metaplasia, | | |
Osseous | | 1 2.0|
Subcutaneous Tissue, Lymphatic, | | |
Dilatation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 35 |
Joint, Tarsal, Hyperostosis | X X X X | 11 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + A + + + | 31 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 33 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 31 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 5| 4| 5| 6| 6| 7| | |
DAY ON TEST | 4| 7| 3| 3| 4| 2| 1| 0| 7| 3| | |
| 4| 8| 1| 1| 2| 7| 0| 4| 5| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Atrophy, Diffuse | 4 | 1 4.0|
Lens, Cataract | | 1 3.0|
Retina, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + M + + + + + | 29 |
Hyperplasia, Cystic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 33 |
Inflammation, Acute | 4 | 2 4.0|
Inflammation, Chronic Active | | 1 2.0|
Metaplasia, Osseous | | 1 1.0|
Nephropathy, Chronic | 3 2 2 | 11 1.8|
Pelvis, Inflammation, Acute | | 1 2.0|
Pelvis, Inflammation, Chronic Active | | 1 2.0|
Renal Tubule, Dilatation | | 2 3.0|
Renal Tubule, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Urethra | + | 6 |
Calculus Micro Observation Only | | 2 |
Concretion | 3 | 2 3.0|
Inflammation, Acute | | 2 3.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 34 |
Calculus Micro Observation Only | X | 1 |
Concretion | | 1 3.0|
Dilatation | 2 | 6 2.8|
Inflammation, Acute | 3 | 5 2.2|
Inflammation, Chronic Active | | 1 3.0|
Necrosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 3| 5| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 3| 5| 3|
DAY ON TEST | 3| 2| 2| 2| 5| 8| 3| 0| 5| 3| 3| 2| 0| 2| 6| 3| 3| 3| 3| 3| 3| 2| 1| 7| 4|
| 6| 9| 9| 8| 0| 7| 1| 5| 6| 0| 8| 9| 8| 9| 4| 0| 1| 1| 0| 1| 0| 1| 5| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A A + + + A A + A|
__________________________________________________________________________|
Intestine Large | A + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | A A + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + A + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | A A M + + + A + +|
__________________________________________________________________________|
Intestine Small | A A + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A A + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | A A + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A A + + + + A + +|
__________________________________________________________________________|
Liver | + + A + + + + + + + + + + + + + + + + + + A + +|
Angiectasis | |
Basophilic Focus | X |
Clear Cell Focus | X |
Clear Cell Focus, Multiple | X X |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 2 2 2 2 2 2 |
Hyperplasia | 3 3 3 3 |
Infarct | 3 |
Inflammation, Chronic Active, Diffuse| 1 1 1 1 1 1 1 1 1 2 2 1 1 2 1 2 1 1 2 1 1|
Pigmentation, Multifocal | 2 3 2 2 2 3 2 2 2 3 3 1 2 3 2 3 2 2 2 2 2 2|
Vacuolization Cytoplasmic | 3 |
Bile Duct, Hyperplasia, Multifocal | 3 2 3 2 2 2 2 2 2 2 2 |
Hepatocyte, Cytomegaly, Diffuse | 2 2 2 2 2 3 3 3 2 3 3 2 3 2 3 2 3 2 2 2 2 2|
Hepatocyte, Necrosis, Acute, Diffuse | 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Pancreas | A + + + + + A + +|
__________________________________________________________________________|
Salivary Glands | A + + + + + A + +|
__________________________________________________________________________|
Stomach | A + + + + + A + +|
__________________________________________________________________________|
Stomach, Forestomach | A + + + + + A + +|
__________________________________________________________________________|
Stomach, Glandular | A + + + + + A + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + +|
Degeneration, Chronic | 3 |
Mineralization | |
Atrium, Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + A + + + + + + + + + + + + + + + + + + A + +|
Capsule, Hyperplasia | 2 2 2 2 2 3 2 2 2 2 2 2 1 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + A + + + + + + + + + + + + + + + + + + A + +|
Degeneration, Fatty | 2 |
Hypertrophy | 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 3| 5| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 3| 5| 3|
DAY ON TEST | 3| 2| 2| 2| 5| 8| 3| 0| 5| 3| 3| 2| 0| 2| 6| 3| 3| 3| 3| 3| 3| 2| 1| 7| 4|
| 6| 9| 9| 8| 0| 7| 1| 5| 6| 0| 8| 9| 8| 9| 4| 0| 1| 1| 0| 1| 0| 1| 5| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + A + + + + + + + + + + + + + + + + + + A + +|
Hyperplasia | 2 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | A + + + + + A + +|
__________________________________________________________________________|
Parathyroid Gland | A + + + + + M + M|
__________________________________________________________________________|
Pituitary Gland | M + + + + + A + +|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | A + + + + + M + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + A + +|
Granuloma Sperm | 4 |
__________________________________________________________________________|
Penis | + |
Inflammation, Acute | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | + + |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Prostate | A + + + + + A + +|
Inflammation, Acute | |
Inflammation, Chronic Active | 2 3|
__________________________________________________________________________|
Seminal Vesicle | + + +|
Dilatation | 3 3 |
Inflammation, Chronic Active | 4|
__________________________________________________________________________|
Testes | + + + + + + A + +|
Germinal Epithelium, Degeneration | 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Neutrophilia | |
__________________________________________________________________________|
Bone Marrow | A + + + + + A + +|
Femoral, Hyperplasia, Neutrophil | 4 3 |
__________________________________________________________________________|
Lymph Node | A M + + + + + + + + M + +|
Lumbar, Hyperplasia, Plasma Cell | |
Mesenteric, Hematopoietic Cell | |
Proliferation | 3 3 3 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | A M + + + + M + +|
__________________________________________________________________________|
Spleen | + A + + + + + + + M + +|
Depletion Lymphoid | |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 3 3 3 4 3 2 3 |
__________________________________________________________________________|
Thymus | M + + M M M A + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 3| 5| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 3| 5| 3|
DAY ON TEST | 3| 2| 2| 2| 5| 8| 3| 0| 5| 3| 3| 2| 0| 2| 6| 3| 3| 3| 3| 3| 3| 2| 1| 7| 4|
| 6| 9| 9| 8| 0| 7| 1| 5| 6| 0| 8| 9| 8| 9| 4| 0| 1| 1| 0| 1| 0| 1| 5| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M|
__________________________________________________________________________|
Skin | + A + + + + + + + + + + + I|
Acanthosis | 3 |
Alopecia | |
Hyperkeratosis | |
Ulcer | 3 4 3 |
Subcutaneous Tissue, Fibrosis | 2 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + +|
Joint, Femur, Tibia, Hyperostosis | |
Joint, Tarsal, Hyperostosis | X X X X X X X X |
__________________________________________________________________________|
Skeletal Muscle | + |
Mineralization, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | A + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + +|
Interstitium, Inflammation, Acute | |
Interstitium, Mineralization | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | M + M + + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | A + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic Active | 4|
Nephropathy, Chronic | 2 |
Pelvis, Inflammation, Acute | 2 |
Renal Tubule, Mineralization | 2 |
__________________________________________________________________________|
Urethra | |
Calculus Micro Observation Only | |
Inflammation, Acute | |
__________________________________________________________________________|
Urinary Bladder | A + + + + + A + +|
Dilatation | 4 |
Inflammation, Acute | 4 |
Inflammation, Chronic Active | 3|
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
__________________________________________________________________________________________________________________________________
| 4| 6| 4| 7| 6| 7| 7| 7| 7| 6| 5| 7| 5| 7| 6| 7| 6| 3| 1| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 1| 8| 9| 0| 8| 3| 2| 2| 3| 2| 4| 3| 4| 3| 3| 3| 5| 3| 8| 3| 3| 2| 2| 9| 2| |
| 3| 9| 2| 4| 2| 1| 9| 9| 1| 6| 5| 0| 3| 1| 5| 1| 6| 6| 9| 1| 0| 9| 9| 3| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| A |
100 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Gallbladder | + A + + A A + A | 8 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + A | 12 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 15 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + A | 12 |
__________________________________________________________________________|____________|
Intestine Small | + + + + A + + + | 13 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + A | 12 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + | 13 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + | 13 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Angiectasis | 3 | 1 3.0|
Basophilic Focus | | 1 |
Clear Cell Focus | X X X | 4 |
Clear Cell Focus, Multiple | X X X X X| 7 |
Hematopoietic Cell Proliferation, | | |
Multifocal | 3 3 2 2 2 2 2 2 2 2 2 2 2| 20 2.1|
Hyperplasia | 3 3 | 6 3.0|
Infarct | 4 | 2 3.5|
Inflammation, Chronic Active, Diffuse| 1 1 2 2 2 2 2 2 2 1 2 2 1 2 2 1 1 2 1 1 1| 42 1.4|
Pigmentation, Multifocal | 1 2 2 2 3 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 3 2| 45 2.2|
Vacuolization Cytoplasmic | 2 | 2 2.5|
Bile Duct, Hyperplasia, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 | 22 2.1|
Hepatocyte, Cytomegaly, Diffuse | 2 2 3 3 2 3 3 3 2 2 2 3 2 2 2 2 2 2 1 2 2 3 2 2 3| 47 2.3|
Hepatocyte, Necrosis, Acute, Diffuse | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2| 41 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Stomach | + + + + A + + + | 14 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + A + + + | 14 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + | 14 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 18 |
Degeneration, Chronic | | 1 3.0|
Mineralization | 2 | 1 2.0|
Atrium, Thrombosis | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
__________________________________________________________________________________________________________________________________
| 4| 6| 4| 7| 6| 7| 7| 7| 7| 6| 5| 7| 5| 7| 6| 7| 6| 3| 1| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 1| 8| 9| 0| 8| 3| 2| 2| 3| 2| 4| 3| 4| 3| 3| 3| 5| 3| 8| 3| 3| 2| 2| 9| 2| |
| 3| 9| 2| 4| 2| 1| 9| 9| 1| 6| 5| 0| 3| 1| 5| 1| 6| 6| 9| 1| 0| 9| 9| 3| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| A |
100 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Capsule, Hyperplasia | 2 2 1 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2| 33 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Degeneration, Fatty | 2 | 2 2.0|
Hypertrophy | 1 2 3 2 2 | 10 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + I + + + + + + + + + + + + + + +| 45 |
Hyperplasia | 2 3 2 3 2 1 2| 10 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + M + + | 12 |
__________________________________________________________________________|____________|
Pituitary Gland | + I + + M + + M | 12 |
Pars Distalis, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 17 |
Granuloma Sperm | | 1 4.0|
__________________________________________________________________________|____________|
Penis | + + + + | 5 |
Inflammation, Acute | 3 | 1 3.0|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 6 |
Inflammation, Chronic Active | 3 4 3 | 4 3.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 15 |
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic Active | 3 3 | 4 2.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 4 |
Dilatation | 4 | 3 3.3|
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + | 17 |
Germinal Epithelium, Degeneration | 4 | 3 2.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
Neutrophilia | X | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 15 |
Femoral, Hyperplasia, Neutrophil | | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + +| 24 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
__________________________________________________________________________________________________________________________________
| 4| 6| 4| 7| 6| 7| 7| 7| 7| 6| 5| 7| 5| 7| 6| 7| 6| 3| 1| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 1| 8| 9| 0| 8| 3| 2| 2| 3| 2| 4| 3| 4| 3| 3| 3| 5| 3| 8| 3| 3| 2| 2| 9| 2| |
| 3| 9| 2| 4| 2| 1| 9| 9| 1| 6| 5| 0| 3| 1| 5| 1| 6| 6| 9| 1| 0| 9| 9| 3| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| A |
100 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lumbar, Hyperplasia, Plasma Cell | 3 | 1 3.0|
Mesenteric, Hematopoietic Cell | | |
Proliferation | 2 3 2 3 3 3| 10 2.7|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 12 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + | 23 |
Depletion Lymphoid | 2 2 3 | 3 2.3|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | 3 3 4 3 3 3 3 4 | 15 3.1|
__________________________________________________________________________|____________|
Thymus | + M I + M I + + | 7 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 27 |
Acanthosis | | 1 3.0|
Alopecia | X X | 2 |
Hyperkeratosis | 2 | 1 2.0|
Ulcer | 4 3 | 5 3.4|
Subcutaneous Tissue, Fibrosis | 3 2 | 4 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + I + + + + + + + | 28 |
Joint, Femur, Tibia, Hyperostosis | X | 1 |
Joint, Tarsal, Hyperostosis | X X X X X | 13 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Mineralization, Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 16 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 18 |
Interstitium, Inflammation, Acute | 2 | 1 2.0|
Interstitium, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 17 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + M M | 12 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
__________________________________________________________________________________________________________________________________
| 4| 6| 4| 7| 6| 7| 7| 7| 7| 6| 5| 7| 5| 7| 6| 7| 6| 3| 1| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 1| 8| 9| 0| 8| 3| 2| 2| 3| 2| 4| 3| 4| 3| 3| 3| 5| 3| 8| 3| 3| 2| 2| 9| 2| |
| 3| 9| 2| 4| 2| 1| 9| 9| 1| 6| 5| 0| 3| 1| 5| 1| 6| 6| 9| 1| 0| 9| 9| 3| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| A |
100 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 18 |
Inflammation, Acute | 4 | 1 4.0|
Inflammation, Chronic Active | 3 | 2 3.5|
Nephropathy, Chronic | 2 2 | 3 2.0|
Pelvis, Inflammation, Acute | 2 3 | 3 2.3|
Renal Tubule, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Urethra | + + | 2 |
Calculus Micro Observation Only | X | 1 |
Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + A + | 15 |
Dilatation | 3 3 | 3 3.3|
Inflammation, Acute | | 1 4.0|
Inflammation, Chronic Active | 4 | 2 3.5|
Mucosa, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 5| 4| 6| 7| 5| 5| 7| 1| 7| 5| 3| 2| 3| 3| 3| 5| 7| 7| 7| 7|
DAY ON TEST | 1| 2| 8| 9| 2| 2| 9| 5| 0| 8| 8| 3| 4| 3| 7| 7| 9| 7| 7| 7| 4| 3| 3| 3| 2|
| 0| 9| 0| 0| 9| 8| 0| 6| 1| 2| 4| 1| 2| 0| 0| 6| 9| 6| 6| 6| 5| 0| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + A A + M A A + A A + + + A + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + A A M + M A + + M A + M + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + A + + A + + + A + A + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | M + + A + M A A + A A + + + M + M + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + A + + A M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + A A M + M + + M + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + A A M + A A + + + A + M + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + A A M + A A + + + A + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | |
Clear Cell Focus | X X X |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 3 2 2 2 2 3 2 2 2 3|
Hyperplasia | 3 3 |
Infarct | 3 |
Inflammation, Chronic Active, Diffuse| 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 3 2 2 2 3|
Pigmentation, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Bile Duct, Cyst, Multiple | X |
Bile Duct, Dilatation, Focal | 3 |
Bile Duct, Hyperplasia, Multifocal | 3 2 2 3 3 2 2 2 2 3 2 2 2 2 3 2 2 2 2|
Hepatocyte, Cytomegaly, Diffuse | 4 4 4 4 4 3 4 4 4 4 4 4 2 4 3 2 2 2 3 3 3 4 4 4 4|
Hepatocyte, Necrosis, Acute, Diffuse | 2 2 2 2 2 2 2 2 2 2 2 1 2 1 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Pancreas | + + + A + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Stomach | + + + + + + A + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + M A + + + + + + + + + A + + + + + + + +|
Acanthosis | |
Inflammation, Chronic Active | |
Ulcer, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + A A + + + + + + + + A + + + + A + + +|
Ulcer, Acute | 2 |
__________________________________________________________________________|
Tooth | + + |
Peridontal Tissue, Inflammation, | |
Chronic | 3 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 5| 4| 6| 7| 5| 5| 7| 1| 7| 5| 3| 2| 3| 3| 3| 5| 7| 7| 7| 7|
DAY ON TEST | 1| 2| 8| 9| 2| 2| 9| 5| 0| 8| 8| 3| 4| 3| 7| 7| 9| 7| 7| 7| 4| 3| 3| 3| 2|
| 0| 9| 0| 0| 9| 8| 0| 6| 1| 2| 4| 1| 2| 0| 0| 6| 9| 6| 6| 6| 5| 0| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Degeneration, Chronic | 3 2 |
Mineralization | 2 |
Atrium, Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + A + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 1 2 2 2 2 1 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + A + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2|
Hypertrophy | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + A + + + + + M + + + + + + + + + + + +|
Hyperplasia | 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M M + + + M + + + + M M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + M + + A + + + M + + M + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Inflammation, Focal, Granulomatous | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + A + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Penis | M |
__________________________________________________________________________|
Preputial Gland | + + + + |
Inflammation, Acute | 4 3 3 |
Duct, Dilatation | |
__________________________________________________________________________|
Prostate | + + + + + A A + + + + + + + + + M + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic Active | 2 2 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + |
Dilatation | 3 2 2 |
Inflammation, Acute | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + A + + + + + + + + + + + + + + + + + +|
Necrosis | |
Germinal Epithelium, Degeneration | 2 3 |
Germinal Epithelium, Mineralization | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + A + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Neutrophil | 3 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 5| 4| 6| 7| 5| 5| 7| 1| 7| 5| 3| 2| 3| 3| 3| 5| 7| 7| 7| 7|
DAY ON TEST | 1| 2| 8| 9| 2| 2| 9| 5| 0| 8| 8| 3| 4| 3| 7| 7| 9| 7| 7| 7| 4| 3| 3| 3| 2|
| 0| 9| 0| 0| 9| 8| 0| 6| 1| 2| 4| 1| 2| 0| 0| 6| 9| 6| 6| 6| 5| 0| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + M + + + + + + + + + M + + + + + + + +|
Inguinal, Infiltration Cellular, | |
Plasma Cell | |
Mesenteric, Hematopoietic Cell | |
Proliferation | 2 3 2 2|
Mesenteric, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + M + + + + + + + + + M + + + + + + + +|
Depletion Lymphoid | 2 3 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 2|
__________________________________________________________________________|
Spleen | + + + + + + A + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 3 3 2 3 3 2 |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 3 3 3 2 4 3 2|
__________________________________________________________________________|
Thymus | M + M M + M M M M M M M M M M + M + + + M + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Foreign Body, Focal | 3 |
Ulcer | 3 4 4|
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 3 2 |
Subcutaneous Tissue, Lymphatic, | |
Dilatation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Joint, Femur, Tibia, Hyperostosis | |
Joint, Tarsal, Hyperostosis | X X X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | 3 |
Alveolar Epithelium, Hyperplasia | 2|
Alveolus, Foreign Body | 3 3 3 2 |
Interstitium, Inflammation, Chronic | |
Active, Multifocal | 3 |
Perivascular, Edema, Acute | 3 2 2 |
Perivascular, Edema, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 5| 4| 6| 7| 5| 5| 7| 1| 7| 5| 3| 2| 3| 3| 3| 5| 7| 7| 7| 7|
DAY ON TEST | 1| 2| 8| 9| 2| 2| 9| 5| 0| 8| 8| 3| 4| 3| 7| 7| 9| 7| 7| 7| 4| 3| 3| 3| 2|
| 0| 9| 0| 0| 9| 8| 0| 6| 1| 2| 4| 1| 2| 0| 0| 6| 9| 6| 6| 6| 5| 0| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Atrophy, Diffuse | 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + M + + + M + + + M + + + +|
Acinus, Dilatation | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + A + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | |
Inflammation, Acute | 2 2 2 |
Inflammation, Chronic Active | 3 |
Nephropathy, Chronic | 2 2 2 2 2 2 2 2 2|
Cortex, Cyst | X |
Renal Tubule, Mineralization | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + A A + + + + + + + + + A + + + + + + + +|
Calculus Gross Observation | X |
Dilatation | 3 3 |
Inflammation, Chronic Active | 3 3 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 5| 7| 4| 6| 7| 5| 7| 7| 7| 6| 4| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 4| 2| 3| 4| 3| 9| 3| 4| 9| 3| 1| 2| 3| 2| 5| 7| 4| 1| 3| 2| 3| 2| 3| |
| 0| 0| 0| 9| 1| 9| 0| 8| 1| 6| 0| 1| 2| 9| 0| 9| 4| 6| 4| 9| 1| 9| 6| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| A |
200 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + A + A A + A + + + A A + A + + + +| 32 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + A + + + + + + + + + A + A + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A + + M + A + + + + A + A + + + +| 35 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + A + A + + + +| 41 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + A + + M + M + + + + A + A + + + +| 35 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + A + + + + + + + + + A + A + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A + + + + A + + + + A + A + + + +| 38 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A + + + + M + + + + A + A + + + +| 37 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + + + + A + + + + A + A + + + +| 37 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Angiectasis | 2 | 2 2.0|
Basophilic Focus | X X X X | 4 |
Clear Cell Focus | X X X | 6 |
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 3 2 3 2 2 2 4 2 2 2 2 2 3 2 3| 27 2.3|
Hyperplasia | 3 3 3 | 5 3.0|
Infarct | | 1 3.0|
Inflammation, Chronic Active, Diffuse| 2 3 3 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2| 46 2.1|
Pigmentation, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 46 2.0|
Bile Duct, Cyst, Multiple | | 1 |
Bile Duct, Dilatation, Focal | | 1 3.0|
Bile Duct, Hyperplasia, Multifocal | 2 3 2 2 2 2 3 2 2 2 2 2 2 2 2 2 3 2| 37 2.2|
Hepatocyte, Cytomegaly, Diffuse | 4 4 3 4 4 3 4 3 4 2 3 4 4 4 4 4 3 4 4 4 4 4 4| 48 3.6|
Hepatocyte, Necrosis, Acute, Diffuse | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 45 2.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + A + + + + + + + + + A + A + + + +| 44 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + A + + + + + + + + + A + A + + + +| 44 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + A + + + + + + + + + A + A + + + +| 43 |
Acanthosis | 3 4 | 2 3.5|
Inflammation, Chronic Active | 3 3 | 2 3.0|
Ulcer, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + A + + + + + + + + + A + A + + + +| 42 |
Ulcer, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 5| 7| 4| 6| 7| 5| 7| 7| 7| 6| 4| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 4| 2| 3| 4| 3| 9| 3| 4| 9| 3| 1| 2| 3| 2| 5| 7| 4| 1| 3| 2| 3| 2| 3| |
| 0| 0| 0| 9| 1| 9| 0| 8| 1| 6| 0| 1| 2| 9| 0| 9| 4| 6| 4| 9| 1| 9| 6| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| A |
200 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Peridontal Tissue, Inflammation, | | |
Chronic | 2 | 3 2.7|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Chronic | | 2 2.5|
Mineralization | | 1 2.0|
Atrium, Thrombosis | X | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + A + + + + + + + + + + + A + + + +| 46 |
Capsule, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 27 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + A + + + + + + + + + + + A + + + +| 46 |
Hyperplasia | 2 2 2 | 4 2.0|
Hypertrophy | 2 2 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + A + + + + + + + + + + + A + + + +| 45 |
Hyperplasia | 2 2 1 2 2 3 2| 10 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + A + + + + + + + + + A + A + + + +| 44 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + M + + + +| 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + M + + + + A + + M + + + + + + + + M + + + +| 41 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + +| 47 |
Follicle, Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Inflammation, Focal, Granulomatous | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Penis | | |
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 8 |
Inflammation, Acute | 3 3 3 | 6 3.2|
Duct, Dilatation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + A + + + +| 45 |
Inflammation, Acute | 3 | 1 3.0|
Inflammation, Chronic Active | | 3 2.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 7 |
Dilatation | 2 2 3 | 6 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 5| 7| 4| 6| 7| 5| 7| 7| 7| 6| 4| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 4| 2| 3| 4| 3| 9| 3| 4| 9| 3| 1| 2| 3| 2| 5| 7| 4| 1| 3| 2| 3| 2| 3| |
| 0| 0| 0| 9| 1| 9| 0| 8| 1| 6| 0| 1| 2| 9| 0| 9| 4| 6| 4| 9| 1| 9| 6| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| A |
200 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
Necrosis | 4 | 1 4.0|
Germinal Epithelium, Degeneration | 2 | 3 2.3|
Germinal Epithelium, Mineralization | | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + A + + + + + + + + + A + A + M + +| 44 |
Femoral, Hyperplasia, Neutrophil | 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + M + + + + + + + + + M + M + + + +| 44 |
Inguinal, Infiltration Cellular, | | |
Plasma Cell | 4 | 1 4.0|
Mesenteric, Hematopoietic Cell | | |
Proliferation | 3 2 3 3 2 2 | 10 2.4|
Mesenteric, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + M + M + + + +| 43 |
Depletion Lymphoid | | 2 2.5|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hyperplasia, Lymphoid | 2 3 | 4 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + A + + + + + + + + + + + A + + + +| 46 |
Depletion Lymphoid | 2 2 2 | 10 2.4|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | 3 3 2 4 4 3 2 3 3 3 3 | 18 2.9|
__________________________________________________________________________|____________|
Thymus | + + M + M M M M + M + M + M M M M M M M + + M +| 18 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst Epithelial Inclusion | X | 1 |
Foreign Body, Focal | | 1 3.0|
Ulcer | 4 4 4 | 6 3.8|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | 3 3 2 4 | 6 2.8|
Subcutaneous Tissue, Lymphatic, | | |
Dilatation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05073-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, TECHNICAL GRADE Date: 05/05/97
Route: DOSED FEED Time: 13:53:06
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 5| 7| 4| 6| 7| 5| 7| 7| 7| 6| 4| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 4| 2| 3| 4| 3| 9| 3| 4| 9| 3| 1| 2| 3| 2| 5| 7| 4| 1| 3| 2| 3| 2| 3| |
| 0| 0| 0| 9| 1| 9| 0| 8| 1| 6| 0| 1| 2| 9| 0| 9| 4| 6| 4| 9| 1| 9| 6| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| A |
200 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Joint, Femur, Tibia, Hyperostosis | X X X | 3 |
Joint, Tarsal, Hyperostosis | X X X X X| 9 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage, Acute | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 2 | 2 2.0|
Alveolus, Foreign Body | | 4 2.8|
Interstitium, Inflammation, Chronic | | |
Active, Multifocal | | 1 3.0|
Perivascular, Edema, Acute | 2 | 4 2.3|
Perivascular, Edema, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
Atrophy, Diffuse | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + M + + + + + + + + + + + + + + + A M + + +| 43 |
Acinus, Dilatation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
Infiltration Cellular, Plasma Cell | 2 | 1 2.0|
Inflammation, Acute | 3 | 4 2.3|
Inflammation, Chronic Active | | 1 3.0|
Nephropathy, Chronic | 2 2 2 2 3 2 3 3 2 2 2 2 2| 22 2.1|
Cortex, Cyst | | 1 |
Renal Tubule, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + A + + + + + + + + + A + A + + + +| 43 |
Calculus Gross Observation | | 1 |
Dilatation | | 2 3.0|
Inflammation, Chronic Active | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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