TR 349 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/09/94
EXP: 05073 TECHNICAL GRADE PENTACHLOROPHENOL TIME: 05:37:17
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 55378
CONT: N01-ES-38068 CAS: 87-86-5
PATHOLOGIST: R. PERSING S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
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REMOVAL DATE RANGE:
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NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/09/94
EXP: 05073 TECHNICAL GRADE PENTACHLOROPHENOL TIME: 05:37:17
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 55378
CONT: N01-ES-38068 CAS: 87-86-5
PATHOLOGIST: R. PERSING S. EUSTIS
TECHNICAL GRADE PENTACHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 35 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 12 |
| |
| UNCENSORED DEATHS |
| 102 126 187 265 286 330 349 363 417 426 |
| 427 427 475 498 510 542 544 552 598 604 |
| 675 678 679 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 26 CENSORED DEATHS 0 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 189 315 336 349 350 413 492 521 538 543 |
| 545 556 577 587 626 628 635 636 656 664 |
| 682 689 693 704 705 708 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 200 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 24 CENSORED DEATHS 4 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 142 299 446 476 490 512 528 545 549 570 |
| 582 584 590 598 619 636 640 644 654 656 |
| 680 690 701 710 |
| CENSORED DEATHS |
| 376 376 376 376 |
| |
==================================================================================
TECHNICAL GRADE PENTACHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 94.3 88.6 77.1 74.3 62.9 51.4 42.9 42.9 34.3 |
| | |
| | |
|100 PPM | 100.0 100.0 98.0 90.0 88.0 88.0 78.0 72.0 60.0 48.0 |
| | |
| | |
|200 PPM | 100.0 98.0 98.0 96.0 96.0 91.6 82.9 69.8 56.7 48.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 100 PPM 200 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 34.3% 48.0% 48.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.070N P=0.078N P=0.063N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 437.4 551.4 564.2 |
|NATURAL DEATHS (C) | (35.1) (28.2) (26.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 537.4 636.7 621.7 |
|(STANDARD ERROR) | (33.0) (19.3) (19.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TECHNICAL GRADE PENTACHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 35 UNCENSORED DEATHS 6 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 153 183 605 635 635 674 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 9 CENSORED DEATHS 0 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 382 424 453 476 656 675 692 705 707 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 200 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 224 356 413 430 495 547 618 634 658 661 |
| 673 675 681 682 694 695 710 711 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
TECHNICAL GRADE PENTACHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 97.1 94.3 94.3 94.3 94.3 94.3 91.4 85.7 82.9 |
| | |
| | |
|100 PPM | 100.0 100.0 100.0 100.0 96.0 92.0 92.0 92.0 90.0 82.0 |
| | |
| | |
|200 PPM | 100.0 100.0 98.0 96.0 94.0 92.0 90.0 88.0 80.0 64.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 100 PPM 200 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 82.9% 82.0% 64.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.055 P=1.000 P=0.122 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 480.8 574.4 586.5 |
|NATURAL DEATHS (C) | (99.4) (45.5) (33.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 686.5 701.2 677.7 |
|(STANDARD ERROR) | (22.5) (11.5) (15.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TECHNICAL GRADE PENTACHLOROPHENOL
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
100 PPM = 2
200 PPM = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3 2
| 1 1 3 2 3 2
| 1 1 3 2 2 2 3 3
| 1 1 3 3
90 + 2 2 3 3
| 1 1 2 2 3 3
P | 1 1 2 2323
E | 1 1 223
R 80 + 1 1 3 3
C | 1 1 2 2 3 3
E | 11 2 22 3
N | 2 33 2
T 70 + 3 3
| 322
S | 1 1 23 2
U | 1 1 2 2
R 60 + 11 3 3 2 2
V | 1 1 3 22
I | 32 2
V | 11 3 3
A 50 + 22
L | 1 1 2 2
| 11
| 1 1
40 +
|
| 1 1
|
30 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 16 obs hidden.
TECHNICAL GRADE PENTACHLOROPHENOL
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
100 PPM = 2
200 PPM = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3 2
|
| 3 3 2 2
| 1 1
96 + 3 3 2 2
|
| 1 3 3 2 2 1
|
92 + 3 2 3 2
| 1 1
P | 3 3 2 2
E |
R 88 + 3 3 2 2
C |
E | 3 1 1 2 2
N |
T 84 + 3 3
| 1 1
S | 3 3 2 2
U |
R 80 + 3 3
V |
I |
V |
A 76 + 33
L |
|
|
72 + 3 3
|
|
|
68 + 3 3
|
|
|
64 + 3 3
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 3 obs hidden.
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