TR 349 Mouse Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
DOWICIDE EC-7 PENTACHLOROPHENOL
NTP Experiment-Test: 05074-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/09/94
Route: DOSED FEED Time: 06:47:16
Facility: Battelle Columbus Laboratory
Chemical CAS #: 87-86-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05074-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DOWICIDE EC-7 PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 06:47:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 100 PPM 200 PPM 600 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 35 50 50 50
Early Deaths
Natural Death 3 15 10 11
Moribund Sacrifice 3 6 2
Drowned 1
Survivors
Terminal Sacrifice 29 28 38 39
Animals Examined Microscopically 35 50 50 49
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (34) (10) (3) (45)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%)
Intestine Large, Colon (34) (13) (4) (47)
Parasite Metazoan 1 (25%)
Intestine Small, Ileum (34) (10) (3) (46)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%)
Liver (34) (50) (49) (48)
Basophilic Focus 1 (3%) 1 (2%)
Clear Cell Focus 1 (3%) 2 (4%) 1 (2%) 13 (27%)
Clear Cell Focus, Multiple 12 (24%) 13 (27%)
Cytomegaly, Diffuse 1 (2%)
Degeneration, Cystic 6 (12%) 1 (2%)
Hematopoietic Cell Proliferation, Multifocal 20 (59%) 37 (74%) 35 (71%) 45 (94%)
Infarct 2 (6%) 2 (4%)
Inflammation, Chronic Active, Diffuse 4 (8%) 29 (59%) 47 (98%)
Inflammation, Chronic Active, Focal 1 (2%)
Pigmentation, Multifocal 4 (8%) 32 (65%) 48 (100%)
Bile Duct, Cyst 1 (2%) 2 (4%)
Bile Duct, Cyst, Multiple 1 (2%)
Bile Duct, Hyperplasia, Multifocal 1 (2%) 40 (83%)
Hepatocyte, Cytomegaly, Diffuse 37 (74%) 49 (100%) 47 (98%)
Hepatocyte, Cytomegaly, Focal 1 (2%)
Hepatocyte, Necrosis, Acute, Diffuse 21 (42%) 49 (100%) 48 (100%)
Hepatocyte, Necrosis, Acute, Focal 2 (6%) 4 (8%)
Mesentery (4) (1) (2)
Inflammation, Acute 1 (100%)
Inflammation, Chronic Active 3 (75%)
Pancreas (34) (16) (7) (46)
Hyperplasia, Lymphoid 1 (6%)
Acinus, Atrophy 5 (15%) 1 (6%)
Duct, Cyst 1 (3%) 1 (6%)
Duct, Ectasia 2 (6%) 1 (14%)
Duct, Hyperplasia 1 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05074-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DOWICIDE EC-7 PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 06:47:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 100 PPM 200 PPM 600 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Duct, Inflammation, Chronic 1 (3%)
Salivary Glands (35) (12) (3) (46)
Hyperplasia, Lymphoid 1 (2%)
Stomach, Glandular (33) (13) (5) (47)
Necrosis, Acute, Focal 1 (8%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (35) (14) (5) (48)
Inflammation, Chronic 1 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (35) (50) (47) (49)
Capsule, Cyst 1 (3%) 1 (2%)
Capsule, Hyperplasia 35 (100%) 49 (98%) 47 (100%) 49 (100%)
Corticomedullary Junction, Cyst 2 (4%)
Adrenal Gland, Cortex (35) (49) (47) (49)
Accessory Adrenal Cortical Nodule 1 (2%)
Cyst 1 (2%)
Degeneration, Fatty 2 (4%)
Hematopoietic Cell Proliferation 1 (3%) 1 (2%)
Hyperplasia 2 (6%) 1 (2%)
Hypertrophy 6 (17%) 2 (4%) 5 (11%)
Hypertrophy, Focal 1 (2%)
Adrenal Gland, Medulla (35) (49) (46) (49)
Hyperplasia 2 (6%) 1 (2%) 5 (11%) 17 (35%)
Pituitary Gland (32) (17) (9) (44)
Pars Distalis, Cyst 1 (3%)
Pars Distalis, Hyperplasia 16 (50%) 2 (22%) 19 (43%)
Thyroid Gland (34) (14) (4) (46)
Inflammation, Chronic 1 (3%) 1 (2%)
Ultimobranchial Cyst 1 (2%)
Follicle, Cyst 2 (6%) 1 (25%) 2 (4%)
Follicular Cell, Hyperplasia 5 (15%) 5 (11%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05074-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DOWICIDE EC-7 PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 06:47:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 100 PPM 200 PPM 600 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (34) (24) (17) (48)
Angiectasis 2 (6%)
Hyperplasia, Tubular 1 (6%)
Inflammation, Chronic Active 3 (9%) 8 (33%) 4 (24%)
Follicle, Cyst 11 (32%) 7 (29%) 10 (59%) 12 (25%)
Periovarian Tissue, Cyst 3 (9%) 3 (13%) 5 (29%) 3 (6%)
Uterus (34) (36) (41) (47)
Angiectasis 1 (3%)
Inflammation, Acute 4 (11%) 4 (10%)
Inflammation, Chronic Active 1 (3%) 1 (2%)
Thrombosis 2 (6%)
Endometrium, Hyperplasia, Cystic, Glandular,
Multifocal 31 (91%) 30 (83%) 37 (90%) 40 (85%)
Endometrium, Hyperplasia, Cystic, Multifocal,
Reticulum Cell 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (1)
Lymphocytosis 1 (100%)
Bone Marrow (35) (13) (5) (48)
Femoral, Hyperplasia, Diffuse, Neutrophil 1 (20%)
Femoral, Hyperplasia, Neutrophil 3 (23%) 1 (20%)
Femoral, Myelofibrosis 13 (37%) 1 (20%) 20 (42%)
Lymph Node (34) (23) (11) (44)
Lumbar, Hematopoietic Cell Proliferation 1 (2%)
Mediastinal, Hyperplasia, Lymphoid 1 (4%)
Mediastinal, Inflammation, Acute 1 (4%)
Mesenteric, Hematopoietic Cell Proliferation 1 (4%) 4 (36%) 4 (9%)
Mesenteric, Hematopoietic Cell Proliferation,
Multifocal 3 (7%)
Mesenteric, Hyperplasia, Lymphoid 1 (3%)
Renal, Hematopoietic Cell Proliferation 1 (2%)
Renal, Hyperplasia, Lymphoid 1 (3%)
Lymph Node, Mandibular (33) (16) (4) (42)
Hyperplasia, Lymphoid 1 (3%) 1 (6%) 2 (5%)
Pigmentation, Diffuse 1 (3%)
Spleen (34) (26) (17) (47)
Depletion Lymphoid 1 (2%)
Hemorrhage 1 (6%)
Hyperplasia, Lymphoid 1 (4%) 2 (4%)
Necrosis 1 (3%) 1 (6%)
Red Pulp, Hematopoietic Cell Proliferation,
Diffuse 1 (3%) 8 (31%) 5 (29%) 5 (11%)
Thymus (30) (9) (5) (43)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05074-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DOWICIDE EC-7 PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 06:47:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 100 PPM 200 PPM 600 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Degeneration, Acute 1 (3%)
Inflammation, Acute 1 (20%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (33) (6) (7) (40)
Hyperplasia, Cystic 19 (58%) 2 (33%) 31 (78%)
Skin (35) (22) (18) (46)
Alopecia 5 (14%) 1 (5%) 7 (39%) 2 (4%)
Ulcer 1 (2%)
Sebaceous Gland, Hyperplasia 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic
Active 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (35) (14) (5) (49)
Femur, Hyperostosis 1 (2%)
Joint, Tarsal, Hyperostosis 1 (20%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (35) (14) (5) (47)
Compression 1 (3%)
Meninges, Infiltration Cellular, Lymphocyte 6 (17%) 5 (11%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (35) (15) (6) (48)
Hyperplasia, Lymphoid 2 (4%)
Alveolar Epithelium, Hyperplasia 1 (3%) 1 (2%)
Interstitium, Inflammation, Chronic Active 1 (17%)
Mediastinum, Inflammation, Acute 2 (33%)
Nose (35) (14) (5) (48)
Glands, Inflammation, Acute, Focal 2 (40%) 46 (96%)
Olfactory Epithelium, Metaplasia, Focal 1 (3%) 2 (40%) 45 (94%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05074-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DOWICIDE EC-7 PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 06:47:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 100 PPM 200 PPM 600 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Atrophy 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (34) (15) (8) (48)
Infarct 1 (2%)
Nephropathy, Chronic 3 (9%) 3 (6%)
Glomerulus, Amyloid Deposition, Diffuse 1 (7%)
Glomerulus, Inflammation, Chronic, Diffuse 1 (2%)
Renal Tubule, Dilatation 1 (7%)
Renal Tubule, Regeneration 2 (6%) 5 (10%)
Urinary Bladder (34) (12) (5) (47)
Dilatation 1 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05074-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DOWICIDE EC-7 PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 06:47:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 100 PPM 200 PPM 600 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 35 50 50 50
Early Deaths
Moribund Sacrifice 2 3 4 6
Natural Death 8 19 17 9
Survivors
Terminal Sacrifice 25 28 29 35
Animals Examined Microscopically 35 50 50 49
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (31) (6) (8) (47)
Prolapse 1 (2%)
Liver (35) (48) (48) (49)
Basophilic Focus 1 (3%) 3 (6%) 2 (4%)
Clear Cell Focus 2 (4%) 4 (8%)
Clear Cell Focus, Multiple 17 (35%) 21 (44%) 15 (31%)
Degeneration, Cystic 2 (4%) 1 (2%)
Hematopoietic Cell Proliferation, Diffuse 1 (2%)
Hematopoietic Cell Proliferation, Multifocal 1 (3%) 20 (42%) 16 (33%) 40 (82%)
Hyperplasia, Focal 2 (4%) 3 (6%)
Infarct 2 (6%) 1 (2%) 1 (2%) 2 (4%)
Inflammation, Acute 1 (3%)
Inflammation, Chronic Active, Diffuse 36 (75%) 44 (92%) 43 (88%)
Pigmentation, Multifocal 40 (83%) 37 (77%) 45 (92%)
Thrombosis, Multiple 1 (2%)
Bile Canaliculi, Hyperplasia, Atypical,
Diffuse 1 (2%)
Bile Duct, Cyst 2 (4%) 3 (6%) 1 (2%)
Bile Duct, Cyst, Multifocal 2 (4%)
Bile Duct, Cyst, Multiple 2 (4%)
Bile Duct, Hyperplasia, Multifocal 1 (3%) 3 (6%) 5 (10%) 32 (65%)
Hepatocyte, Cytomegaly, Diffuse 48 (100%) 48 (100%) 47 (96%)
Hepatocyte, Necrosis, Acute, Diffuse 47 (98%) 47 (98%) 46 (94%)
Hepatocyte, Necrosis, Acute, Focal 1 (3%)
Pancreas (34) (12) (14) (49)
Acinus, Atrophy 2 (6%) 1 (8%)
Acinus, Degeneration 1 (2%)
Acinus, Inflammation, Chronic 1 (2%)
Duct, Ectasia 1 (8%)
Stomach, Forestomach (33) (11) (15) (49)
Acanthosis 1 (9%) 2 (4%)
Hyperkeratosis 1 (9%)
Inflammation, Acute 1 (3%)
Inflammation, Chronic Active 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05074-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DOWICIDE EC-7 PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 06:47:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 100 PPM 200 PPM 600 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Ulcer 1 (9%) 1 (2%)
Stomach, Glandular (33) (11) (15) (49)
Dysplasia 3 (6%)
Ulcer, Acute 1 (3%)
Tooth (3)
Developmental Malformation 1 (33%)
Peridontal Tissue, Inflammation, Chronic
Active 2 (67%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (35) (13) (17) (49)
Degeneration, Chronic 1 (6%)
Mineralization 1 (3%)
Atrium, Thrombosis 1 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (34) (48) (49) (49)
Capsule, Ectopic Tissue 3 (9%)
Capsule, Hyperplasia 30 (88%) 34 (71%) 34 (69%) 29 (59%)
Adrenal Gland, Cortex (34) (48) (48) (49)
Cyst 1 (3%)
Cytoplasmic Alteration 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 6 (18%) 7 (15%) 1 (2%) 1 (2%)
Hypertrophy 4 (12%) 3 (6%) 6 (13%) 1 (2%)
Adrenal Gland, Medulla (34) (48) (48) (49)
Hyperplasia 1 (3%) 19 (40%) 13 (27%) 1 (2%)
Pituitary Gland (29) (9) (14) (38)
Pars Distalis, Cyst 1 (3%)
Thyroid Gland (35) (11) (14) (48)
Follicle, Cyst 1 (3%)
Follicular Cell, Hyperplasia 3 (9%) 2 (4%)
Follicular Cell, Hypertrophy 1 (9%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05074-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DOWICIDE EC-7 PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 06:47:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 100 PPM 200 PPM 600 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (35) (13) (18) (49)
Granuloma Sperm 1 (2%)
Spermatocele 1 (8%)
Penis (6) (6) (1) (4)
Inflammation, Acute 1 (25%)
Inflammation, Chronic Active 3 (50%) 1 (17%) 1 (100%)
Preputial Gland (3) (8) (4) (4)
Dilatation 1 (13%)
Hyperplasia 1 (13%)
Inflammation, Chronic Active 1 (33%) 6 (75%) 4 (100%) 4 (100%)
Duct, Dilatation 2 (67%) 2 (25%) 2 (50%)
Prostate (34) (11) (15) (49)
Inflammation, Acute 1 (9%) 3 (20%)
Inflammation, Chronic Active 1 (3%) 1 (9%) 1 (7%)
Seminal Vesicle (1) (3) (2) (1)
Dilatation 2 (67%)
Inflammation, Chronic Active 1 (100%) 1 (33%)
Testes (35) (12) (18) (49)
Inflammation, Chronic Active 1 (3%)
Germinal Epithelium, Degeneration 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (3) (1)
Neutrophilia 3 (100%) 1 (100%)
Bone Marrow (35) (10) (14) (49)
Femoral, Hyperplasia, Diffuse, Neutrophil 1 (10%)
Femoral, Hyperplasia, Neutrophil 2 (6%) 1 (10%) 1 (7%)
Lymph Node (31) (14) (22) (47)
Angiectasis 1 (7%)
Hyperplasia, Plasma Cell 1 (7%)
Lumbar, Hyperplasia, Lymphoid 1 (3%)
Mesenteric, Hematopoietic Cell Proliferation 5 (16%) 4 (29%) 10 (45%) 10 (21%)
Mesenteric, Hematopoietic Cell Proliferation,
Multifocal 1 (3%) 1 (7%)
Mesenteric, Hyperplasia, Lymphoid 1 (2%)
Pancreatic, Inflammation, Chronic Active 1 (3%)
Lymph Node, Mandibular (31) (8) (13) (47)
Depletion Lymphoid 1 (8%)
Hyperplasia, Lymphoid 1 (2%)
Necrosis 1 (8%)
Spleen (34) (19) (20) (49)
Angiectasis 1 (3%)
Cyst 1 (5%)
Depletion Lymphoid 5 (15%) 3 (16%) 6 (30%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05074-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DOWICIDE EC-7 PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 06:47:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 100 PPM 200 PPM 600 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Necrosis 1 (5%)
Red Pulp, Hematopoietic Cell Proliferation,
Diffuse 5 (15%) 8 (42%) 7 (35%) 7 (14%)
Thymus (21) (5) (11) (27)
Necrosis, Acute 1 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (34) (32) (26) (49)
Acanthosis 3 (9%) 3 (9%) 1 (4%) 10 (20%)
Alopecia 5 (15%) 8 (25%) 2 (8%) 12 (24%)
Cyst Epithelial Inclusion 1 (3%)
Hyperkeratosis 1 (3%)
Inflammation, Acute 1 (3%)
Inflammation, Chronic Active 1 (4%)
Metaplasia, Focal, Osseous 1 (3%)
Necrosis 1 (3%)
Ulcer 2 (6%) 5 (16%) 4 (15%) 5 (10%)
Ulcer, Focal 1 (4%)
Subcutaneous Tissue, Fibrosis 1 (2%)
Subcutaneous Tissue, Inflammation, Acute 2 (8%) 2 (4%)
Subcutaneous Tissue, Inflammation, Chronic 1 (3%)
Subcutaneous Tissue, Inflammation, Chronic
Active 2 (6%) 3 (9%) 5 (19%) 2 (4%)
Subcutaneous Tissue, Mineralization 1 (2%)
Subcutaneous Tissue, Necrosis, Acute 1 (4%)
Subcutaneous Tissue, Lymphatic, Dilatation 3 (9%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (35) (36) (29) (49)
Joint, Tarsal, Hyperostosis 18 (51%) 26 (72%) 14 (48%) 12 (24%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (35) (12) (16) (49)
Cyst Epithelial Inclusion 1 (3%)
Meninges, Infiltration Cellular, Lymphocyte 1 (3%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05074-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DOWICIDE EC-7 PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 06:47:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 100 PPM 200 PPM 600 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (35) (15) (19) (49)
Alveolar Epithelium, Hyperplasia 1 (3%) 1 (7%) 2 (4%)
Alveolar Epithelium, Hyperplasia, Focal 1 (7%)
Alveolar Epithelium, Bronchiole, Hyperplasia 1 (2%)
Peribronchiolar, Glands, Inflammation, Acute 1 (2%)
Perivascular, Infiltration Cellular,
Lymphocyte 2 (4%)
Nose (35) (13) (16) (49)
Glands, Inflammation, Acute, Focal 4 (11%) 1 (8%) 3 (19%) 47 (96%)
Nasolacrimal Duct, Inflammation, Acute, Focal 1 (8%) 2 (4%)
Olfactory Epithelium, Atrophy 1 (6%)
Olfactory Epithelium, Metaplasia, Focal 2 (6%) 1 (8%) 2 (13%) 46 (94%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1)
Cornea, Hyperplasia, Focal 1 (100%)
Lens, Cataract 1 (100%)
Harderian Gland (27) (12) (13) (35)
Inflammation, Chronic Active 1 (3%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (35) (14) (20) (49)
Cyst 4 (8%)
Hydronephrosis 1 (3%) 1 (7%) 1 (5%)
Infarct 1 (3%)
Inflammation, Acute 2 (14%) 1 (5%)
Inflammation, Chronic Active 3 (9%) 2 (10%)
Nephropathy, Chronic 1 (3%) 1 (2%)
Capsule, Fibrosis 1 (3%)
Pelvis, Inflammation, Acute 1 (5%)
Renal Tubule, Dilatation 3 (9%) 2 (10%) 1 (2%)
Renal Tubule, Dilatation, Diffuse 1 (5%)
Renal Tubule, Metaplasia, Osseous 1 (5%)
Renal Tubule, Mineralization 1 (5%)
Renal Tubule, Regeneration 12 (34%) 17 (35%)
Urethra (3) (2) (4)
Calculus Micro Observation Only 2 (67%) 1 (50%) 2 (50%)
Inflammation, Acute 1 (50%) 3 (75%)
Inflammation, Chronic Active 1 (33%)
Urinary Bladder (33) (11) (15) (49)
Calculus Micro Observation Only 1 (3%)
Dilatation 5 (15%) 3 (27%) 8 (53%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05074-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DOWICIDE EC-7 PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 06:47:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 100 PPM 200 PPM 600 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Inflammation, Acute 1 (9%)
Inflammation, Chronic Active 1 (3%) 1 (7%)
Mucosa, Hyperplasia 1 (3%) 1 (9%) 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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