TR 349 Mouse Pathology Tables
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
Facility: Battelle Columbus Laboratory
Chemical CAS #: 87-86-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 8| 2| 3| 2| 2| 2| 2| 3| 2| 4| 2| 2| 2| 2| 2| 3| 2| 3| 2| 2| 3| 9|
| 7| 2| 8| 5| 8| 0| 9| 9| 8| 9| 0| 8| 3| 8| 8| 7| 7| 8| 0| 8| 0| 8| 7| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + A + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + + + +|
Leiomyoma | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +|
Peyer's Patch, Lymphoma Malignant | |
Histiocytic | |
Peyer's Patch, Lymphoma Malignant | |
Lymphocytic | X X X |
Peyer's Patch, Lymphoma Malignant | |
Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + A + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + M + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + A + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + A + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X |
Pars Distalis, Adenoma, Multiple | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + A + + + + + + + + + + + +|
Follicular Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 8| 2| 3| 2| 2| 2| 2| 3| 2| 4| 2| 2| 2| 2| 2| 3| 2| 3| 2| 2| 3| 9|
| 7| 2| 8| 5| 8| 0| 9| 9| 8| 9| 0| 8| 3| 8| 8| 7| 7| 8| 0| 8| 0| 8| 7| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + A + + + + + + + + + + + +|
Periovarian Tissue, Lymphoma | |
Malignant Mixed | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + A + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lumbar, Lymphoma Malignant | |
Histiocytic | |
Mediastinal, Lymphoma Malignant | |
Histiocytic | |
Mediastinal, Lymphoma Malignant Mixed| X |
Mesenteric, Lymphoma Malignant | |
Histiocytic | |
Mesenteric, Lymphoma Malignant Mixed | X X |
Renal, Lymphoma Malignant Histiocytic| |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + A + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X X X X X X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + M + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X X X X X X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M M M + + + + + + + + M + +|
Lymphoma Malignant Mixed | X |
Thymoma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Adenocarcinoma | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 8| 2| 3| 2| 2| 2| 2| 3| 2| 4| 2| 2| 2| 2| 2| 3| 2| 3| 2| 2| 3| 9|
| 7| 2| 8| 5| 8| 0| 9| 9| 8| 9| 0| 8| 3| 8| 8| 7| 7| 8| 0| 8| 0| 8| 7| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | X |
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Lymphoma Malignant Histiocytic | |
Mediastinum, Lymphoma Malignant | |
Lymphocytic | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + M + + + M + + + + + + M + M + + + +|
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + A + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X X X X X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + A + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X X X X X X X |
Lymphoma Malignant Mixed | X X X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 1| 2| 2| 3| 3| 2| 2| 2| 2| 2| | |
| 7| 8| 0| 0| 0| 7| 7| 8| 7| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + M + | 32 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 34 |
Leiomyoma | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 34 |
Peyer's Patch, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Peyer's Patch, Lymphoma Malignant | | |
Lymphocytic | X | 4 |
Peyer's Patch, Lymphoma Malignant | | |
Mixed | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 34 |
Hepatocellular Adenoma | X | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 34 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 35 |
Lymphoma Malignant Lymphocytic | | 3 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 33 |
Squamous Cell Papilloma | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 33 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 35 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + I + + + + + | 32 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 5
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 1| 2| 2| 3| 3| 2| 2| 2| 2| 2| | |
| 7| 8| 0| 0| 0| 7| 7| 8| 7| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Adenoma | X X X | 9 |
Pars Distalis, Adenoma, Multiple | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 34 |
Follicular Cell, Adenoma | X | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 34 |
Periovarian Tissue, Lymphoma | | |
Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 34 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 34 |
Lymphoma Malignant Lymphocytic | | 1 |
Lumbar, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mediastinal, Lymphoma Malignant Mixed| | 1 |
Mesenteric, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mesenteric, Lymphoma Malignant Mixed | | 2 |
Renal, Lymphoma Malignant Histiocytic| X | 1 |
Renal, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 33 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | | 8 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 34 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X | 10 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + | 30 |
Lymphoma Malignant Mixed | | 1 |
Thymoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 1| 2| 2| 3| 3| 2| 2| 2| 2| 2| | |
| 7| 8| 0| 0| 0| 7| 7| 8| 7| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + + + + | 33 |
Adenocarcinoma | X | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 35 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 35 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 35 |
Adenocarcinoma, Metastatic, Mammary | | |
Gland | | 1 |
Alveolar/Bronchiolar Adenoma | | 1 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Mediastinum, Lymphoma Malignant | | |
Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 34 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + M + + + + + + + | 29 |
Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 34 |
Lymphoma Malignant Lymphocytic | X | 8 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 34 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 35 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 1| 2| 2| 3| 3| 2| 2| 2| 2| 2| | |
| 7| 8| 0| 0| 0| 7| 7| 8| 7| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Lymphoma Malignant Lymphocytic | X X | 11 |
Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 6| 5| 7| 7| 4| 7| 4| 3| 7| 7| 7| 6|
DAY ON TEST | 5| 2| 2| 2| 0| 2| 3| 2| 2| 3| 2| 2| 6| 2| 9| 3| 2| 4| 2| 8| 2| 2| 2| 2| 4|
| 4| 8| 9| 8| 1| 7| 0| 7| 8| 0| 1| 7| 6| 9| 6| 0| 7| 3| 7| 3| 1| 7| 9| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
100 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + |
__________________________________________________________________________|
Gallbladder | A + + A + + + + |
__________________________________________________________________________|
Intestine Large | A + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | A + + A + + A + |
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + |
Leiomyoma | |
__________________________________________________________________________|
Intestine Large, Rectum | A + + + M + + + |
__________________________________________________________________________|
Intestine Small | A + + + + + A + |
__________________________________________________________________________|
Intestine Small, Duodenum | A A + + + + A + |
__________________________________________________________________________|
Intestine Small, Ileum | A + + A + + A + |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + A + + A + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Multiple | |
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant | X |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Mesentery | + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Pancreas | + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | M + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + A + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Adenoma | X |
Capsule, Carcinoma | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 6| 5| 7| 7| 4| 7| 4| 3| 7| 7| 7| 6|
DAY ON TEST | 5| 2| 2| 2| 0| 2| 3| 2| 2| 3| 2| 2| 6| 2| 9| 3| 2| 4| 2| 8| 2| 2| 2| 2| 4|
| 4| 8| 9| 8| 1| 7| 0| 7| 8| 0| 1| 7| 6| 9| 6| 0| 7| 3| 7| 3| 1| 7| 9| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
100 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | M + + + + M + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + |
Pars Distalis, Adenoma | X X |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Periovarian Tissue, Lymphoma | |
Malignant Lymphocytic | X |
Periovarian Tissue, Lymphoma | |
Malignant | X |
Periovarian Tissue, Lymphoma | |
Malignant Mixed | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | A + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + |
Lymphoma Malignant | X |
Axillary, Lymphoma Malignant | |
Histiocytic | |
Deep Cervical, Lymphoma Malignant | |
Mixed | |
Inguinal, Lymphoma Malignant | |
Lymphocytic | X |
Inguinal, Lymphoma Malignant | X |
Inguinal, Lymphoma Malignant Mixed | |
Lumbar, Lymphoma Malignant | |
Histiocytic | |
Lumbar, Lymphoma Malignant | |
Lymphocytic | X |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 6| 5| 7| 7| 4| 7| 4| 3| 7| 7| 7| 6|
DAY ON TEST | 5| 2| 2| 2| 0| 2| 3| 2| 2| 3| 2| 2| 6| 2| 9| 3| 2| 4| 2| 8| 2| 2| 2| 2| 4|
| 4| 8| 9| 8| 1| 7| 0| 7| 8| 0| 1| 7| 6| 9| 6| 0| 7| 3| 7| 3| 1| 7| 9| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
100 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Lymphoma Malignant Mixed| X |
Mesenteric, Lymphoma Malignant | |
Histiocytic | |
Mesenteric, Lymphoma Malignant | |
Lymphocytic | X |
Mesenteric, Lymphoma Malignant Mixed | X X |
Pancreatic, Lymphoma Malignant | |
Histiocytic | |
Renal, Lymphoma Malignant Histiocytic| |
Renal, Lymphoma Malignant Lymphocytic| X |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant | X |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Thymus | + + M M M M + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M + M M +|
Adenocarcinoma | X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
Sarcoma, Metastatic, Skin | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 6| 5| 7| 7| 4| 7| 4| 3| 7| 7| 7| 6|
DAY ON TEST | 5| 2| 2| 2| 0| 2| 3| 2| 2| 3| 2| 2| 6| 2| 9| 3| 2| 4| 2| 8| 2| 2| 2| 2| 4|
| 4| 8| 9| 8| 1| 7| 0| 7| 8| 0| 1| 7| 6| 9| 6| 0| 7| 3| 7| 3| 1| 7| 9| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
100 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Nose | + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + + + + M + + + |
Adenoma | X |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 5| 5| 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 7| 4| 3| 3| 3| 2| 1| 6| 1| 4| 3| 1| 2| 3| 3| 2| 6| 2| 2| 2| 2| |
| 0| 0| 0| 7| 2| 2| 0| 1| 0| 8| 3| 9| 4| 5| 6| 2| 7| 0| 0| 7| 4| 9| 9| 0| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
100 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 14 |
__________________________________________________________________________|____________|
Gallbladder | + A + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + | 14 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 13 |
Leiomyoma | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma, Multiple | X | 1 |
Hepatocellular Carcinoma | X | 1 |
Hepatocellular Adenoma | X | 3 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Mixed | X X X X | 6 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 16 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + M | 12 |
__________________________________________________________________________|____________|
Stomach | + + + + + + | 14 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 14 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 13 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 14 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Capsule, Adenoma | X | 2 |
Capsule, Carcinoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 5| 5| 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 7| 4| 3| 3| 3| 2| 1| 6| 1| 4| 3| 1| 2| 3| 3| 2| 6| 2| 2| 2| 2| |
| 0| 0| 0| 7| 2| 2| 0| 1| 0| 8| 3| 9| 4| 5| 6| 2| 7| 0| 0| 7| 4| 9| 9| 0| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
100 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pheochromocytoma Malignant | X | 1 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 16 |
Carcinoma | X | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + | 11 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + | 17 |
Pars Distalis, Adenoma | X | 3 |
Pars Intermedia, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + | 24 |
Lymphoma Malignant Mixed | X | 2 |
Periovarian Tissue, Lymphoma | | |
Malignant Lymphocytic | | 1 |
Periovarian Tissue, Lymphoma | | |
Malignant | | 1 |
Periovarian Tissue, Lymphoma | | |
Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + +| 36 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 13 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + | 23 |
Lymphoma Malignant | | 1 |
Axillary, Lymphoma Malignant | | |
Histiocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 5| 5| 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 7| 4| 3| 3| 3| 2| 1| 6| 1| 4| 3| 1| 2| 3| 3| 2| 6| 2| 2| 2| 2| |
| 0| 0| 0| 7| 2| 2| 0| 1| 0| 8| 3| 9| 4| 5| 6| 2| 7| 0| 0| 7| 4| 9| 9| 0| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
100 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Deep Cervical, Lymphoma Malignant | | |
Mixed | X | 1 |
Inguinal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Inguinal, Lymphoma Malignant | | 1 |
Inguinal, Lymphoma Malignant Mixed | X X | 2 |
Lumbar, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mediastinal, Lymphoma Malignant Mixed| X X X | 4 |
Mesenteric, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mesenteric, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mesenteric, Lymphoma Malignant Mixed | X X X X X | 7 |
Pancreatic, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Renal, Lymphoma Malignant Histiocytic| X | 1 |
Renal, Lymphoma Malignant Lymphocytic| | 1 |
Renal, Lymphoma Malignant Mixed | X X X X X | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M | 16 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + | 26 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Mixed | X X X X X | 7 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Thymus | M + M + + + + | 9 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 5| 5| 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 7| 4| 3| 3| 3| 2| 1| 6| 1| 4| 3| 1| 2| 3| 3| 2| 6| 2| 2| 2| 2| |
| 0| 0| 0| 7| 2| 2| 0| 1| 0| 8| 3| 9| 4| 5| 6| 2| 7| 0| 0| 7| 4| 9| 9| 0| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
100 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M M + M | 6 |
Adenocarcinoma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 22 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 14 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Sarcoma, Metastatic, Skin | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + | 15 |
Alveolar/Bronchiolar Adenoma | | 2 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + | 14 |
__________________________________________________________________________|____________|
Trachea | + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + M M + + | 12 |
Adenoma | | 1 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + | 15 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Mixed | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 5| 5| 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 7| 4| 3| 3| 3| 2| 1| 6| 1| 4| 3| 1| 2| 3| 3| 2| 6| 2| 2| 2| 2| |
| 0| 0| 0| 7| 2| 2| 0| 1| 0| 8| 3| 9| 4| 5| 6| 2| 7| 0| 0| 7| 4| 9| 9| 0| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
100 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urethra | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + M + + + | 12 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 4 |
Lymphoma Malignant Mixed | X X X X X X X | 11 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 2| 2| 3| 9| 2| 1| 2| 2| 2| 2| 3| 0| 3| 3| 2| 8| 3| 2| 2| 2| 2| 2|
| 0| 8| 8| 8| 7| 0| 9| 9| 1| 9| 8| 7| 7| 5| 6| 0| 0| 9| 9| 0| 7| 9| 9| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
200 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + |
__________________________________________________________________________|
Gallbladder | A |
__________________________________________________________________________|
Intestine Large | + |
__________________________________________________________________________|
Intestine Large, Cecum | + |
__________________________________________________________________________|
Intestine Large, Colon | + |
__________________________________________________________________________|
Intestine Large, Rectum | + |
__________________________________________________________________________|
Intestine Small | + |
__________________________________________________________________________|
Intestine Small, Duodenum | + |
__________________________________________________________________________|
Intestine Small, Ileum | + |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | X |
Hemangiosarcoma, Multiple | X |
Hemangiosarcoma, Metastatic, Spleen | X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + |
Hemangiosarcoma, Metastatic, Spleen | |
__________________________________________________________________________|
Salivary Glands | M |
__________________________________________________________________________|
Stomach | + |
__________________________________________________________________________|
Stomach, Forestomach | + |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Stomach, Glandular | + |
__________________________________________________________________________|
Tongue | |
Mucosa, Dorsal, Squamous Cell | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + A + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + |
__________________________________________________________________________|
Parathyroid Gland | M |
__________________________________________________________________________|
Pituitary Gland | + I + + + + |
Pars Distalis, Adenoma | X X X |
__________________________________________________________________________|
Thyroid Gland | + |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 2| 2| 3| 9| 2| 1| 2| 2| 2| 2| 3| 0| 3| 3| 2| 8| 3| 2| 2| 2| 2| 2|
| 0| 8| 8| 8| 7| 0| 9| 9| 1| 9| 8| 7| 7| 5| 6| 0| 0| 9| 9| 0| 7| 9| 9| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
200 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Periovarian Tissue, Lymphoma | |
Malignant Mixed | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Leiomyoma | X |
Lymphoma Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + |
__________________________________________________________________________|
Lymph Node | + + M + + +|
Lumbar, Lymphoma Malignant | |
Lymphocytic | X|
Lumbar, Lymphoma Malignant Mixed | X |
Mesenteric, Lymphoma Malignant Mixed | X X |
Renal, Lymphoma Malignant Histiocytic| |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | M + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + |
Hemangiosarcoma | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Thymus | + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + |
Adenocarcinoma | X |
__________________________________________________________________________|
Skin | + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 2| 2| 3| 9| 2| 1| 2| 2| 2| 2| 3| 0| 3| 3| 2| 8| 3| 2| 2| 2| 2| 2|
| 0| 8| 8| 8| 7| 0| 9| 9| 1| 9| 8| 7| 7| 5| 6| 0| 0| 9| 9| 0| 7| 9| 9| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
200 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + |
Alveolar/Bronchiolar Adenoma | |
Lymphoma Malignant Histiocytic | |
Mediastinum, Lymphoma Malignant Mixed| |
__________________________________________________________________________|
Nose | + |
__________________________________________________________________________|
Trachea | + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | M |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Urinary Bladder | + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X X|
Lymphoma Malignant Mixed | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 0| 3| 3| 3| 3| 2| 1| 2| 3| 2| 3| 2| 2| 2| 2| 2| 2| 4| 3| 2| 2| 2| 2| 1| |
| 9| 7| 0| 0| 0| 6| 7| 4| 7| 0| 7| 1| 7| 8| 8| 9| 9| 6| 8| 0| 9| 7| 7| 8| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
200 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + M + + | 4 |
__________________________________________________________________________|____________|
Gallbladder | + A + + | 3 |
__________________________________________________________________________|____________|
Intestine Large | + + + + A | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + A | 3 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A | 4 |
__________________________________________________________________________|____________|
Intestine Small | + A + + A | 4 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + A | 3 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + A | 3 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + A | 3 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Hemangiosarcoma, Multiple | | 1 |
Hemangiosarcoma, Metastatic, Spleen | X | 2 |
Hepatocellular Adenoma | X X | 5 |
Hepatocellular Adenoma, Multiple | | 1 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 7 |
Hemangiosarcoma, Metastatic, Spleen | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + M + + | 3 |
__________________________________________________________________________|____________|
Stomach | + + + + A | 5 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + A | 5 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A | 5 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
Mucosa, Dorsal, Squamous Cell | | |
Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + A + + + + + A| 47 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + A + + + + + A| 47 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + A + + + + + A| 46 |
Pheochromocytoma Benign | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 0| 3| 3| 3| 3| 2| 1| 2| 3| 2| 3| 2| 2| 2| 2| 2| 2| 4| 3| 2| 2| 2| 2| 1| |
| 9| 7| 0| 0| 0| 6| 7| 4| 7| 0| 7| 1| 7| 8| 8| 9| 9| 6| 8| 0| 9| 7| 7| 8| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
200 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 5 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + | 3 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + A| 9 |
Pars Distalis, Adenoma | X | 4 |
__________________________________________________________________________|____________|
Thyroid Gland | + M + + | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 17 |
Lymphoma Malignant Histiocytic | X | 1 |
Periovarian Tissue, Lymphoma | | |
Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 41 |
Leiomyoma | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 11 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Lumbar, Lymphoma Malignant Mixed | | 1 |
Mesenteric, Lymphoma Malignant Mixed | X | 3 |
Renal, Lymphoma Malignant Histiocytic| X | 1 |
Renal, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 4 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + A + + + + + | 17 |
Hemangiosarcoma | X | 2 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | X X X | 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Thymus | M + + + | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 0| 3| 3| 3| 3| 2| 1| 2| 3| 2| 3| 2| 2| 2| 2| 2| 2| 4| 3| 2| 2| 2| 2| 1| |
| 9| 7| 0| 0| 0| 6| 7| 4| 7| 0| 7| 1| 7| 8| 8| 9| 9| 6| 8| 0| 9| 7| 7| 8| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
200 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + +| 7 |
Adenocarcinoma | X| 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + | 18 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Hemangiosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 6 |
Alveolar/Bronchiolar Adenoma | X | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Mediastinum, Lymphoma Malignant Mixed| X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + | 5 |
__________________________________________________________________________|____________|
Trachea | + M + + | 4 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + M + + | 4 |
Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 8 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 5 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Histiocytic | X X | 3 |
Lymphoma Malignant Lymphocytic | X | 4 |
Lymphoma Malignant Mixed | X X X | 6 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 0| 2| 2| 2| 2| 3| 3| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 7| 2| 8| 2| 2| 2|
| 2| 9| 9| 8| 7| 0| 0| 7| 7| 8| 7| 9| 8| 9| 9| 7| 9| 7| 8| 0| 9| 9| 9| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
600 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + + + + + + + + + + + + + + + + + A + A + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Lymphoma Malignant | |
Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Hemangiosarcoma | X X |
Hemangiosarcoma, Multiple | X |
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X X X X X X X X X X X X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Mesentery | + |
Hemangiosarcoma | |
Myxosarcoma, Metastatic, Skin | X |
__________________________________________________________________________|
Pancreas | A + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + M + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Spleen | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X X X X |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 0| 2| 2| 2| 2| 3| 3| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 7| 2| 8| 2| 2| 2|
| 2| 9| 9| 8| 7| 0| 0| 7| 7| 8| 7| 9| 8| 9| 9| 7| 9| 7| 8| 0| 9| 9| 9| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
600 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Bilateral, Pheochromocytoma Benign | X X X X X X X X X X X X|
__________________________________________________________________________|
Islets, Pancreatic | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + I + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periovarian Tissue, Lymphoma | |
Malignant Histiocytic | |
Periovarian Tissue, Lymphoma | |
Malignant Lymphocytic | |
Periovarian Tissue, Lymphoma | |
Malignant Mixed | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyoma | X |
Leiomyosarcoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Lymph Node | M + + + + + + + + + + + + + + + + + + + + M + + +|
Lymphoma Malignant Lymphocytic | X |
Deep Cervical, Lymphoma Malignant | |
Histiocytic | |
Lumbar, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Lymphoma Malignant | |
Histiocytic | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Lymphoma Malignant Mixed| X |
Mesenteric, Lymphoma Malignant | |
Lymphocytic | X X X |
Mesenteric, Lymphoma Malignant Mixed | X |
Pancreatic, Lymphoma Malignant | |
Histiocytic | |
Pancreatic, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 0| 2| 2| 2| 2| 3| 3| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 7| 2| 8| 2| 2| 2|
| 2| 9| 9| 8| 7| 0| 0| 7| 7| 8| 7| 9| 8| 9| 9| 7| 9| 7| 8| 0| 9| 9| 9| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
600 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + M + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X X X X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + A + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X X X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + M + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M + + + + + + + + + + + + + + + + + M M + + +|
Adenocarcinoma | X X X |
__________________________________________________________________________|
Skin | A + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Myxosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | A + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | |
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
Mediastinum, Lymphoma Malignant Mixed| X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | A + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | A + + + M M M M + + + + + + M M M M M M M + M + +|
Adenoma | X X |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 0| 2| 2| 2| 2| 3| 3| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 7| 2| 8| 2| 2| 2|
| 2| 9| 9| 8| 7| 0| 0| 7| 7| 8| 7| 9| 8| 9| 9| 7| 9| 7| 8| 0| 9| 9| 9| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
600 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X X X X |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| |
DAY ON TEST | 2| 2| 3| 2| 2| 5| 1| 2| 2| 2| 1| 2| 5| 2| 2| 2| 3| 3| 3| 3| 1| 2| 2| 2| 8| |
| 9| 7| 0| 7| 8| 5| 6| 8| 8| 8| 1| 9| 3| 9| 8| 9| 0| 0| 0| 0| 2| 8| 8| 7| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
600 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + A M + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + A A + + + A + A + + + + + + + + + + + | 42 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + A A + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A A + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A A + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A A + + + M + + + + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A A + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A A + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A A + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A A + + + + + + + + + + + + + + + + + | 47 |
Peyer's Patch, Lymphoma Malignant | | |
Mixed | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + A + + + + + + + + + + + + + + + + + + | 48 |
Hemangioma | | 1 |
Hemangiosarcoma | X X | 4 |
Hemangiosarcoma, Multiple | X X X | 4 |
Hepatocellular Carcinoma | X | 2 |
Hepatocellular Adenoma | X X X X X X | 9 |
Hepatocellular Adenoma, Multiple | X X X X X X X X X | 21 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Hemangiosarcoma | X | 1 |
Myxosarcoma, Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + A A + + + + + + + + + + + + + + + + + | 46 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + M + M + + + + + + + + + + + + + + + + + | 46 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + A A + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + A A + + + + + + + + + + + + + + + + + | 47 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + A A + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + M + + + + + + + + + + + + + + + + + | 48 |
Hemangiosarcoma, Metastatic, Spleen | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| |
DAY ON TEST | 2| 2| 3| 2| 2| 5| 1| 2| 2| 2| 1| 2| 5| 2| 2| 2| 3| 3| 3| 3| 1| 2| 2| 2| 8| |
| 9| 7| 0| 7| 8| 5| 6| 8| 8| 8| 1| 9| 3| 9| 8| 9| 0| 0| 0| 0| 2| 8| 8| 7| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
600 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Pheochromocytoma Malignant | X | 1 |
Pheochromocytoma Benign | X X X | 9 |
Bilateral, Pheochromocytoma Benign | X X X X X X X X X X X X X X X X X | 29 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + A A + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M M + + + + + + + M M + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + M + + M M + + + + + + + + + + + + + + + + + | 44 |
Pars Distalis, Adenoma | X | 6 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + A M + + + + + + + + M + + + + + + + + | 46 |
Follicular Cell, Adenoma | X | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + A + + + + + + + + + + + + + + + + + + | 48 |
Periovarian Tissue, Lymphoma | | |
Malignant Histiocytic | X | 1 |
Periovarian Tissue, Lymphoma | | |
Malignant Lymphocytic | X | 1 |
Periovarian Tissue, Lymphoma | | |
Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + A + + + + + + + + + + + + + + + + + + | 47 |
Leiomyoma | | 1 |
Leiomyosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + A + + + + + + + + + + + + + + + + + + | 48 |
Hemangiosarcoma | X | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + M + + M A + + + + + + + + + + + + + + + + + + | 44 |
Lymphoma Malignant Lymphocytic | | 1 |
Deep Cervical, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Mediastinal, Lymphoma Malignant | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| |
DAY ON TEST | 2| 2| 3| 2| 2| 5| 1| 2| 2| 2| 1| 2| 5| 2| 2| 2| 3| 3| 3| 3| 1| 2| 2| 2| 8| |
| 9| 7| 0| 7| 8| 5| 6| 8| 8| 8| 1| 9| 3| 9| 8| 9| 0| 0| 0| 0| 2| 8| 8| 7| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
600 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Histiocytic | X X | 2 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | X X | 2 |
Mediastinal, Lymphoma Malignant Mixed| | 1 |
Mesenteric, Lymphoma Malignant | | |
Lymphocytic | X X | 5 |
Mesenteric, Lymphoma Malignant Mixed | | 1 |
Pancreatic, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Pancreatic, Lymphoma Malignant | | |
Lymphocytic | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + M A M + + + + + + + + + + + + + + + + M | 42 |
Lymphoma Malignant Histiocytic | X X | 2 |
Lymphoma Malignant Lymphocytic | X X X | 9 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + A + + + + + + + + + + + + + + + + + + | 47 |
Hemangiosarcoma | X X | 2 |
Lymphoma Malignant Histiocytic | X X | 2 |
Lymphoma Malignant Lymphocytic | X X X X X | 10 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Thymus | + + + + + M M + M + M + + + + + + + + + + + + + | 43 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant Mixed | X | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + M M + + + + + + + + M + + + + + M + + | 40 |
Adenocarcinoma | X | 4 |
__________________________________________________________________________|____________|
Skin | + + + + + A A + + + + + + + + + + + + + + + + + | 46 |
Subcutaneous Tissue, Myxosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + M + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + M + + + + + + + + + + + + + + + + + | 48 |
Adenocarcinoma, Metastatic, Mammary | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| |
DAY ON TEST | 2| 2| 3| 2| 2| 5| 1| 2| 2| 2| 1| 2| 5| 2| 2| 2| 3| 3| 3| 3| 1| 2| 2| 2| 8| |
| 9| 7| 0| 7| 8| 5| 6| 8| 8| 8| 1| 9| 3| 9| 8| 9| 0| 0| 0| 0| 2| 8| 8| 7| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
600 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Gland | X | 1 |
Alveolar/Bronchiolar Adenoma | X | 2 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Hepatocellular Carcinoma, Metastatic | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X X | 5 |
Lymphoma Malignant Mixed | | 1 |
Mediastinum, Lymphoma Malignant Mixed| | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + M + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Trachea | + + + + + A M + + + + + + + + + + + + + + + + + | 46 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + M M M + + M M + M + M + M + M M + M + + M M + | 23 |
Adenoma | X | 3 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + A + + + + + + + + + + + + + + + + + + | 48 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X | 4 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + + + + + + + + + M + + + + + + + + | 47 |
Lymphoma Malignant Lymphocytic | X X | 4 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Lymphoma Malignant Histiocytic | X X | 2 |
Lymphoma Malignant Lymphocytic | X X X X X | 11 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 4| 1|
DAY ON TEST | 2| 2| 2| 3| 2| 5| 2| 9| 2| 2| 2| 3| 2| 2| 2| 2| 8| 3| 2| 2| 2| 2| 1| 7| 9|
| 8| 7| 9| 0| 7| 4| 9| 8| 9| 9| 9| 0| 7| 9| 9| 9| 1| 0| 9| 8| 7| 4| 0| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + A + + + + + + + + A + + + + + A A +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + A + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + A + + + + + A + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + A + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + M + + + + + + + + + + + + + + A + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + M + + + + + + + + A + + + + + A + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + A + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X X X X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + M + + + + M M M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + M + I + + + + + + + + + + M +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 4| 1|
DAY ON TEST | 2| 2| 2| 3| 2| 5| 2| 9| 2| 2| 2| 3| 2| 2| 2| 2| 8| 3| 2| 2| 2| 2| 1| 7| 9|
| 8| 7| 9| 0| 7| 4| 9| 8| 9| 9| 9| 0| 7| 9| 9| 9| 1| 0| 9| 8| 7| 4| 0| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Penis | + + + +|
__________________________________________________________________________|
Preputial Gland | + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Lymphoma Malignant | |
Lymphocytic | X |
__________________________________________________________________________|
Lymph Node | + + + + + M + + + + + + + M + + M + + + + + + + +|
Bronchial, Lymphoma Malignant | |
Lymphocytic | |
Lumbar, Lymphoma Malignant Mixed | X X |
Mediastinal, Lymphoma Malignant | |
Histiocytic | X |
Mediastinal, Lymphoma Malignant Mixed| X X |
Mesenteric, Lymphoma Malignant | |
Histiocytic | X |
Mesenteric, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + M + + M + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Thymus | + + + M + + + M + + + + M + I + M M M + M M M +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + I + +|
Subcutaneous Tissue, Fibrosarcoma | X X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 4| 1|
DAY ON TEST | 2| 2| 2| 3| 2| 5| 2| 9| 2| 2| 2| 3| 2| 2| 2| 2| 8| 3| 2| 2| 2| 2| 1| 7| 9|
| 8| 7| 9| 0| 7| 4| 9| 8| 9| 9| 9| 0| 7| 9| 9| 9| 1| 0| 9| 8| 7| 4| 0| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X |
Fibrosarcoma, Metastatic, Skin | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + M + + + + M + + + + M + + M M + + + + + + + + M|
Adenoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Urethra | + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + + + + A + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 0| 2| 2| 2| 2| 2| 2| 2| | |
| 0| 8| 5| 9| 8| 8| 8| 9| 9| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Gallbladder | + A + + + + + + + + | 30 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 32 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + + + + + + + | 31 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 33 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + M + + + + + + + + | 31 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + M + + + + + + + + | 30 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 32 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 35 |
Hemangioma | | 1 |
Hepatocellular Carcinoma | | 1 |
Hepatocellular Adenoma | X | 5 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Pancreas | + M + + + + + + + + | 34 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 35 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Stomach | + M + + + + + + + + | 33 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + M + + + + + + + + | 33 |
__________________________________________________________________________|____________|
Stomach, Glandular | + M + + + + + + + + | 33 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 35 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + A + + + + + + + + | 34 |
Capsule, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + A + + + + + + + + | 34 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + A + + + + + + + + | 34 |
Pheochromocytoma Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 0| 2| 2| 2| 2| 2| 2| 2| | |
| 0| 8| 5| 9| 8| 8| 8| 9| 9| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + M + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + M + + + + | 28 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + M + + + | 29 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 35 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 35 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Penis | + + | 6 |
__________________________________________________________________________|____________|
Preputial Gland | + | 3 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Seminal Vesicle | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 35 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 3 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 35 |
Femoral, Lymphoma Malignant | | |
Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + I + + + + + + + + | 31 |
Bronchial, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Lumbar, Lymphoma Malignant Mixed | | 2 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | | 1 |
Mediastinal, Lymphoma Malignant Mixed| | 2 |
Mesenteric, Lymphoma Malignant | | |
Histiocytic | | 1 |
Mesenteric, Lymphoma Malignant Mixed | | 1 |
Renal, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + I + + + + + + + + | 31 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X X | 3 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Spleen | + A + + + + + + + + | 34 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 36
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 0| 2| 2| 2| 2| 2| 2| 2| | |
| 0| 8| 5| 9| 8| 8| 8| 9| 9| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | X X | 3 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Thymus | + M + + M + + + M + | 21 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 34 |
Subcutaneous Tissue, Fibrosarcoma | X | 4 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 35 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 35 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 35 |
Alveolar/Bronchiolar Adenoma | X | 5 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
Pheochromocytoma Malignant, | | |
Metastatic, Adrenal Gland | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 35 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + M M + + + + + + | 27 |
Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 35 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Urethra | + | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 33 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 35 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 0| 2| 2| 2| 2| 2| 2| 2| | |
| 0| 8| 5| 9| 8| 8| 8| 9| 9| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X X | 3 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
_____________________________________________________________________________________________________________________
| 6| 4| 2| 6| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7|
DAY ON TEST | 9| 7| 5| 1| 2| 5| 2| 2| 2| 2| 1| 3| 5| 0| 2| 2| 2| 5| 3| 2| 1| 6| 2| 2| 2|
| 5| 7| 4| 3| 7| 9| 9| 8| 8| 8| 1| 0| 5| 5| 9| 8| 8| 9| 0| 9| 3| 8| 7| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | A M + + + + |
__________________________________________________________________________|
Gallbladder | A A A + A + |
__________________________________________________________________________|
Intestine Large | A + + + A + |
__________________________________________________________________________|
Intestine Large, Cecum | A M M + A + |
__________________________________________________________________________|
Intestine Large, Colon | A + + + A + |
__________________________________________________________________________|
Intestine Large, Rectum | A M A + A M |
__________________________________________________________________________|
Intestine Small | A + + + A + |
__________________________________________________________________________|
Intestine Small, Duodenum | A A + + A |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + A |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + A |
__________________________________________________________________________|
Liver | + A + + + + + + + + + + + + + + + + + + A + + + +|
Fibrosarcoma, Metastatic, Skin | |
Hemangiosarcoma | |
Hemangiosarcoma, Multiple | X X |
Hepatocellular Carcinoma | X X X|
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | X X X |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Pancreas | A + + + A + |
__________________________________________________________________________|
Salivary Glands | A M + + + + |
__________________________________________________________________________|
Stomach | A + + + A + |
__________________________________________________________________________|
Stomach, Forestomach | A + + + A + |
__________________________________________________________________________|
Stomach, Glandular | A + + + A + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + A + + + + + + + + + + + + + + + + + + A + + + +|
Capsule, Adenoma | X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + A + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + A + + + + + + + + + + + + + + + + + + A + + + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | A + + + A + |
__________________________________________________________________________|
Parathyroid Gland | A M M + + + |
__________________________________________________________________________|
Pituitary Gland | M M + + M + |
__________________________________________________________________________|
Thyroid Gland | A M + + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
_____________________________________________________________________________________________________________________
| 6| 4| 2| 6| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7|
DAY ON TEST | 9| 7| 5| 1| 2| 5| 2| 2| 2| 2| 1| 3| 5| 0| 2| 2| 2| 5| 3| 2| 1| 6| 2| 2| 2|
| 5| 7| 4| 3| 7| 9| 9| 8| 8| 8| 1| 0| 5| 5| 9| 8| 8| 9| 0| 9| 3| 8| 7| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Penis | + + + +|
__________________________________________________________________________|
Preputial Gland | + + + |
__________________________________________________________________________|
Prostate | A + + + A + |
__________________________________________________________________________|
Seminal Vesicle | + + |
__________________________________________________________________________|
Testes | + + + + A + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | A + + + A + |
__________________________________________________________________________|
Lymph Node | A M M + + + + M |
Mesenteric, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | A M M + + M |
__________________________________________________________________________|
Spleen | A + + + + + A + +|
Hemangiosarcoma | |
Hemangiosarcoma, Multiple | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Thymus | M M M M A M |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M |
__________________________________________________________________________|
Skin | + A + + + + + + + + + + + + + + + + |
Papilloma, Multiple | |
Sebaceous Gland, Carcinoma | X |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | X X X X |
Subcutaneous Tissue, Fibrosarcoma, | |
Multiple | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
Intercostal, Fibrosarcoma, | |
Metastatic, Skin | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | A + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + |
Alveolar/Bronchiolar Adenoma | |
Interstitium, Mediastinum, | |
Fibrosarcoma, Multiple, | |
Metastatic, Skin | X |
__________________________________________________________________________|
Nose | + + + + + + |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
_____________________________________________________________________________________________________________________
| 6| 4| 2| 6| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7|
DAY ON TEST | 9| 7| 5| 1| 2| 5| 2| 2| 2| 2| 1| 3| 5| 0| 2| 2| 2| 5| 3| 2| 1| 6| 2| 2| 2|
| 5| 7| 4| 3| 7| 9| 9| 8| 8| 8| 1| 0| 5| 5| 9| 8| 8| 9| 0| 9| 3| 8| 7| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | A M + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + M + + + A + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | A + + + + + + A + |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | A + + + A + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
__________________________________________________________________________________________________________________________________
| 6| 3| 6| 7| 4| 7| 4| 5| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| |
DAY ON TEST | 1| 0| 9| 2| 3| 2| 4| 3| 1| 2| 2| 3| 2| 6| 3| 2| 2| 2| 2| 2| 9| 2| 2| 2| 8| |
| 2| 5| 0| 9| 1| 7| 0| 2| 2| 8| 3| 0| 7| 3| 0| 8| 7| 9| 7| 7| 7| 8| 8| 7| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| A |
100 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + +| 11 |
__________________________________________________________________________|____________|
Gallbladder | + A A + A + A| 5 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + A +| 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A M + + A A| 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A +| 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + A +| 6 |
__________________________________________________________________________|____________|
Intestine Small | + A M + + A A| 7 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A M + + A A| 5 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A M + + A A| 6 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A M + + A A| 6 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Fibrosarcoma, Metastatic, Skin | X | 1 |
Hemangiosarcoma | X | 1 |
Hemangiosarcoma, Multiple | | 2 |
Hepatocellular Carcinoma | X X X | 6 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | X X X X X X | 10 |
Hepatocellular Adenoma, Multiple | | 3 |
Lymphoma Malignant Histiocytic | X X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + +| 12 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + +| 11 |
__________________________________________________________________________|____________|
Stomach | + + + + + + +| 11 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + +| 11 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + +| 11 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + +| 13 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Capsule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pheochromocytoma Benign | X X X X | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + +| 11 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + +| 10 |
__________________________________________________________________________|____________|
Pituitary Gland | + + M + + + +| 9 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + +| 11 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
__________________________________________________________________________________________________________________________________
| 6| 3| 6| 7| 4| 7| 4| 5| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| |
DAY ON TEST | 1| 0| 9| 2| 3| 2| 4| 3| 1| 2| 2| 3| 2| 6| 3| 2| 2| 2| 2| 2| 9| 2| 2| 2| 8| |
| 2| 5| 0| 9| 1| 7| 0| 2| 2| 8| 3| 0| 7| 3| 0| 8| 7| 9| 7| 7| 7| 8| 8| 7| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| A |
100 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + +| 13 |
__________________________________________________________________________|____________|
Penis | + + | 6 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 8 |
__________________________________________________________________________|____________|
Prostate | + + + + + + +| 11 |
__________________________________________________________________________|____________|
Seminal Vesicle | + | 3 |
__________________________________________________________________________|____________|
Testes | + + + + + + +| 12 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + A| 10 |
__________________________________________________________________________|____________|
Lymph Node | + M + + + + + + + + +| 14 |
Mesenteric, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + +| 8 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + +| 19 |
Hemangiosarcoma | X | 1 |
Hemangiosarcoma, Multiple | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X X | 2 |
__________________________________________________________________________|____________|
Thymus | + + M + + + M| 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + +| 32 |
Papilloma, Multiple | X | 1 |
Sebaceous Gland, Carcinoma | | 1 |
Subcutaneous Tissue, Fibroma | X | 2 |
Subcutaneous Tissue, Fibrosarcoma | | 4 |
Subcutaneous Tissue, Fibrosarcoma, | | |
Multiple | X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + +| 36 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Intercostal, Fibrosarcoma, | | |
Metastatic, Skin | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + +| 12 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
__________________________________________________________________________________________________________________________________
| 6| 3| 6| 7| 4| 7| 4| 5| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| |
DAY ON TEST | 1| 0| 9| 2| 3| 2| 4| 3| 1| 2| 2| 3| 2| 6| 3| 2| 2| 2| 2| 2| 9| 2| 2| 2| 8| |
| 2| 5| 0| 9| 1| 7| 0| 2| 2| 8| 3| 0| 7| 3| 0| 8| 7| 9| 7| 7| 7| 8| 8| 7| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| A |
100 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + +| 15 |
Alveolar/Bronchiolar Adenoma | X | 1 |
Interstitium, Mediastinum, | | |
Fibrosarcoma, Multiple, | | |
Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + +| 13 |
__________________________________________________________________________|____________|
Trachea | + + + + + + +| 11 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + +| 12 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + +| 14 |
__________________________________________________________________________|____________|
Urethra | + | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + A +| 11 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X X | 2 |
Lymphoma Malignant Mixed | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3| 7| 6| 1| 3| 7| 7| 5| 7| 2| 2| 7| 2| 2|
DAY ON TEST | 8| 1| 2| 3| 2| 3| 2| 2| 3| 3| 2| 5| 2| 6| 4| 1| 2| 3| 9| 2| 9| 9| 2| 9| 9|
| 1| 6| 9| 0| 7| 0| 9| 8| 0| 0| 4| 2| 7| 0| 0| 5| 7| 0| 8| 9| 3| 2| 7| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + A + + A +|
__________________________________________________________________________|
Gallbladder | + + A + + A A A A A|
__________________________________________________________________________|
Intestine Large | + + + + + A + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A M + A A + A A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + A A M A A|
__________________________________________________________________________|
Intestine Small | + + + M + A A + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + A M + A A + A +|
__________________________________________________________________________|
Intestine Small, Ileum | A + A M + A A + A A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + M + A A + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + A + + + + A +|
Hemangioma | |
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X X X X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Pancreas | + + M + + A + + M +|
__________________________________________________________________________|
Salivary Glands | + + + + + A + + A +|
__________________________________________________________________________|
Stomach | + + + + + A A + A +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + A A + A +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + A A + A +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + A +|
Pheochromocytoma Benign | X |
Bilateral, Pheochromocytoma Benign | X X X X X X X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + M + + A + + M +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + M M M M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + M I + M +|
__________________________________________________________________________|
Thyroid Gland | + + + + + M M + A +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3| 7| 6| 1| 3| 7| 7| 5| 7| 2| 2| 7| 2| 2|
DAY ON TEST | 8| 1| 2| 3| 2| 3| 2| 2| 3| 3| 2| 5| 2| 6| 4| 1| 2| 3| 9| 2| 9| 9| 2| 9| 9|
| 1| 6| 9| 0| 7| 0| 9| 8| 0| 0| 4| 2| 7| 0| 0| 5| 7| 0| 8| 9| 3| 2| 7| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + |
__________________________________________________________________________|
Prostate | + + + + + M M + + +|
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + A A A A +|
Femoral, Lymphoma Malignant | |
Histiocytic | |
__________________________________________________________________________|
Lymph Node | + + + + + + + M + + + M|
Lumbar, Lymphoma Malignant Mixed | |
Mesenteric, Lymphoma Malignant | |
Histiocytic | |
Mesenteric, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + M|
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Spleen | + + + + + + A A + A +|
Hemangiosarcoma | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Thymus | + + + M + M M + A +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + I + + + + + A + + + + +|
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + A + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Fibrosarcoma, Metastatic, Skin | |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Nose | + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3| 7| 6| 1| 3| 7| 7| 5| 7| 2| 2| 7| 2| 2|
DAY ON TEST | 8| 1| 2| 3| 2| 3| 2| 2| 3| 3| 2| 5| 2| 6| 4| 1| 2| 3| 9| 2| 9| 9| 2| 9| 9|
| 1| 6| 9| 0| 7| 0| 9| 8| 0| 0| 4| 2| 7| 0| 0| 5| 7| 0| 8| 9| 3| 2| 7| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + A + + A +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + M + M + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + A + + + +|
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urethra | + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + A A + A +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 1| 6| 7| 5| 7| 7| 3| 7| 0| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 5| 2| 2| 2| 3| 9| 2| 4| 2| 2| 4| 2| 2| 2| 2| 3| 2| 0| 0| 2| 3| 2| 7| 2| 3| |
| 1| 9| 9| 9| 4| 0| 9| 1| 7| 8| 2| 7| 6| 9| 8| 0| 7| 8| 3| 7| 0| 8| 8| 9| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| A |
200 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + M + + + + | 15 |
__________________________________________________________________________|____________|
Gallbladder | + + + A + A A + | 9 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + + M M + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + M M M + + | 8 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + M + + | 13 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + M + + | 11 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + M M + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + M M + + | 12 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemangioma | X | 1 |
Hemangiosarcoma | X | 2 |
Hepatocellular Carcinoma | X X X X | 6 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | X X X X X X | 9 |
Hepatocellular Adenoma, Multiple | X X X X| 8 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + M + + + + | 14 |
__________________________________________________________________________|____________|
Salivary Glands | + + + M + + + + | 15 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + M + + + + | 17 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pheochromocytoma Benign | X X X | 4 |
Bilateral, Pheochromocytoma Benign | X X X X X X X| 17 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + M + + + + | 14 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M M + + + + | 11 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + | 14 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + M + + + + | 14 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 1| 6| 7| 5| 7| 7| 3| 7| 0| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 5| 2| 2| 2| 3| 9| 2| 4| 2| 2| 4| 2| 2| 2| 2| 3| 2| 0| 0| 2| 3| 2| 7| 2| 3| |
| 1| 9| 9| 9| 4| 0| 9| 1| 7| 8| 2| 7| 6| 9| 8| 0| 7| 8| 3| 7| 0| 8| 8| 9| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| A |
200 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Penis | + | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + | 4 |
__________________________________________________________________________|____________|
Prostate | + + + + + M + + | 15 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 2 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + | 18 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 14 |
Femoral, Lymphoma Malignant | | |
Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + M + + + + M M + + + + + + | 22 |
Lumbar, Lymphoma Malignant Mixed | X X | 2 |
Mesenteric, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mesenteric, Lymphoma Malignant Mixed | X X | 2 |
Renal, Lymphoma Malignant Mixed | X X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + M M + + + | 13 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + M + + + + + +| 20 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X X X | 3 |
__________________________________________________________________________|____________|
Thymus | M + + M + + M + | 11 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + +| 26 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | X X X X X | 6 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + +| 29 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + M + + + + | 16 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 49
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 1| 6| 7| 5| 7| 7| 3| 7| 0| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 5| 2| 2| 2| 3| 9| 2| 4| 2| 2| 4| 2| 2| 2| 2| 3| 2| 0| 0| 2| 3| 2| 7| 2| 3| |
| 1| 9| 9| 9| 4| 0| 9| 1| 7| 8| 2| 7| 6| 9| 8| 0| 7| 8| 3| 7| 0| 8| 8| 9| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| A |
200 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + M + + + + | 19 |
Alveolar/Bronchiolar Adenoma | | 1 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Fibrosarcoma, Metastatic, Skin | X | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + M + + + | 16 |
__________________________________________________________________________|____________|
Trachea | + + + M + + + + | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + M M + M + | 13 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + +| 20 |
Renal Tubule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Urethra | | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + A + + | 15 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 50
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 3| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 0| 0| 2| 3| 2| 6| 2| 2| 3| 5| 3| 2| 2| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 3| 0|
| 8| 4| 7| 0| 9| 5| 7| 9| 0| 7| 0| 9| 8| 5| 0| 0| 8| 8| 8| 8| 8| 8| 8| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
600 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + M + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + M + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + +|
Peyer's Patch, Lymphoma Malignant | |
Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Hemangioma, Multiple | X |
Hemangiosarcoma | |
Hemangiosarcoma, Multiple | |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X X X X |
Hepatocellular Adenoma, Multiple | X X X X X X X X X X X |
Lymphoma Malignant Histiocytic | X|
Lymphoma Malignant Mixed | |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | X X |
Pheochromocytoma Benign | X X X|
Bilateral, Pheochromocytoma Malignant| X |
Bilateral, Pheochromocytoma Benign | X X X X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 3| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 0| 0| 2| 3| 2| 6| 2| 2| 3| 5| 3| 2| 2| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 3| 0|
| 8| 4| 7| 0| 9| 5| 7| 9| 0| 7| 0| 9| 8| 5| 0| 0| 8| 8| 8| 8| 8| 8| 8| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
600 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + M M M + + + M + M + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + M + M M M M + M + + + + + M|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Lymphoma Malignant Mixed| X |
Mesenteric, Lymphoma Malignant Mixed | X X |
Pancreatic, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Thymus | + + M M + M M + M M + + M + + + M + + M M M + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 3| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 0| 0| 2| 3| 2| 6| 2| 2| 3| 5| 3| 2| 2| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 3| 0|
| 8| 4| 7| 0| 9| 5| 7| 9| 0| 7| 0| 9| 8| 5| 0| 0| 8| 8| 8| 8| 8| 8| 8| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
600 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Hepatocellular Carcinoma, Metastatic | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + M M M + M + + + + + M + + + + +|
Adenoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X|
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 2| 7| 7| 6| 4| 7| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 9| 2| 1| 5| 2| 2| 1| 5| 2| 2| 8| 3| 2| 3| 2| 3| 7| 2| 2| 3| 2| 2| 3| 1| |
| 6| 5| 9| 1| 3| 9| 8| 1| 8| 9| 7| 0| 0| 8| 0| 8| 0| 9| 7| 8| 0| 7| 9| 0| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| A |
600 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + A + + + + + + + + A + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + M + + + + + + + + M + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + M + + + M + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + M + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + M + + + + + + +| 47 |
Peyer's Patch, Lymphoma Malignant | | |
Mixed | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemangioma | X | 1 |
Hemangioma, Multiple | | 1 |
Hemangiosarcoma | X X | 2 |
Hemangiosarcoma, Multiple | X | 1 |
Hepatocellular Carcinoma | X X X X| 8 |
Hepatocellular Carcinoma, Multiple | X | 1 |
Hepatocellular Adenoma | X X X X | 10 |
Hepatocellular Adenoma, Multiple | X X X X X X X X X X X | 22 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Mixed | X | 1 |
Pheochromocytoma Malignant, | | |
Metastatic, Adrenal Gland | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Tooth | + + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 54
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 2| 7| 7| 6| 4| 7| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 9| 2| 1| 5| 2| 2| 1| 5| 2| 2| 8| 3| 2| 3| 2| 3| 7| 2| 2| 3| 2| 2| 3| 1| |
| 6| 5| 9| 1| 3| 9| 8| 1| 8| 9| 7| 0| 0| 8| 0| 8| 0| 9| 7| 8| 0| 7| 9| 0| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| A |
600 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pheochromocytoma Malignant | | 2 |
Pheochromocytoma Benign | X X | 5 |
Bilateral, Pheochromocytoma Malignant| | 1 |
Bilateral, Pheochromocytoma Benign | X X X X X X X X X X X X X X X X X X X X X| 39 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 41 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + + + + + + + I + M + + + + + + +| 38 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Penis | + + + | 4 |
__________________________________________________________________________|____________|
Preputial Gland | + + | 4 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Seminal Vesicle | + | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + M + + + + + + + + + + + + + + + M + + + + + + +| 47 |
Mediastinal, Lymphoma Malignant Mixed| X | 2 |
Mesenteric, Lymphoma Malignant Mixed | X | 3 |
Pancreatic, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + M + + + + + + +| 47 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Thymus | M M + + + + + + + M M M + + + M M M M + + + + + M| 27 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Fibroma | X | 1 |
Subcutaneous Tissue, Fibrosarcoma | X X X X X| 6 |
Subcutaneous Tissue, Sarcoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 55
NTP Experiment-Test: 05074-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:43:51
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 2| 7| 7| 6| 4| 7| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 9| 2| 1| 5| 2| 2| 1| 5| 2| 2| 8| 3| 2| 3| 2| 3| 7| 2| 2| 3| 2| 2| 3| 1| |
| 6| 5| 9| 1| 3| 9| 8| 1| 8| 9| 7| 0| 0| 8| 0| 8| 0| 9| 7| 8| 0| 7| 9| 0| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| A |
600 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Alveolar/Bronchiolar Adenoma | X X | 4 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Hepatocellular Carcinoma, Metastatic | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Pheochromocytoma Malignant, | | |
Metastatic, Adrenal Gland | | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + M M M + + + M M + + + M + M M + + + + + + M| 35 |
Adenoma | X | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 2 |
Renal Tubule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 56
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