TR 349 Mouse Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
DOWICIDE EC-7 PENTACHLOROPHENOL
NTP Experiment-Test: 05074-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/09/94
Route: DOSED FEED Time: 06:47:19
Facility: Battelle Columbus Laboratory
Chemical CAS #: 87-86-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05074-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DOWICIDE EC-7 PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 06:47:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 100 PPM 200 PPM 600 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 35 50 50 50
Early Deaths
Natural Death 3 15 10 11
Moribund Sacrifice 3 6 2
Drowned 1
Survivors
Terminal Sacrifice 29 28 38 39
Animals Examined Microscopically 35 50 50 49
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (34) (10) (3) (45)
Leiomyoma 1 (3%)
Intestine Large, Colon (34) (13) (4) (47)
Leiomyoma 1 (8%)
Intestine Small, Jejunum (34) (10) (3) (47)
Liver (34) (50) (49) (48)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Hemangioma 1 (2%)
Hemangiosarcoma 4 (8%)
Hemangiosarcoma, Multiple 1 (2%) 1 (2%) 4 (8%)
Hemangiosarcoma, Metastatic, Spleen 2 (4%)
Hepatocellular Carcinoma 1 (2%) 2 (4%)
Hepatocellular Adenoma 1 (3%) 3 (6%) 5 (10%) 9 (19%)
Hepatocellular Adenoma, Multiple 1 (2%) 21 (44%)
Mesentery (4) (1) (2)
Hemangiosarcoma 1 (50%)
Myxosarcoma, Metastatic, Skin 1 (50%)
Pancreas (34) (16) (7) (46)
Hemangiosarcoma, Metastatic, Spleen 1 (14%)
Salivary Glands (35) (12) (3) (46)
Stomach, Forestomach (33) (14) (5) (47)
Squamous Cell Papilloma 1 (3%)
Tongue (1)
Mucosa, Dorsal, Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (35) (14) (5) (48)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05074-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DOWICIDE EC-7 PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 06:47:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 100 PPM 200 PPM 600 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (35) (50) (47) (49)
Capsule, Adenoma 2 (4%)
Capsule, Carcinoma 1 (2%)
Adrenal Gland, Cortex (35) (49) (47) (49)
Adrenal Gland, Medulla (35) (49) (46) (49)
Pheochromocytoma Malignant 1 (2%) 1 (2%)
Pheochromocytoma Benign 1 (2%) 2 (4%) 9 (18%)
Bilateral, Pheochromocytoma Benign 29 (59%)
Islets, Pancreatic (34) (16) (5) (46)
Carcinoma 2 (13%)
Pituitary Gland (32) (17) (9) (44)
Pars Distalis, Adenoma 9 (28%) 3 (18%) 4 (44%) 6 (14%)
Pars Distalis, Adenoma, Multiple 1 (3%)
Pars Intermedia, Adenoma 1 (6%)
Thyroid Gland (34) (14) (4) (46)
Follicular Cell, Adenoma 3 (9%) 3 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (34) (24) (17) (48)
Uterus (34) (36) (41) (47)
Leiomyoma 1 (2%) 1 (2%)
Leiomyosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (35) (13) (5) (48)
Hemangiosarcoma 1 (2%)
Lymph Node (34) (23) (11) (44)
Lymph Node, Mandibular (33) (16) (4) (42)
Spleen (34) (26) (17) (47)
Hemangiosarcoma 2 (12%) 2 (4%)
Thymus (30) (9) (5) (43)
Thymoma Malignant 1 (3%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05074-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DOWICIDE EC-7 PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 06:47:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 100 PPM 200 PPM 600 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (33) (6) (7) (40)
Adenocarcinoma 3 (9%) 1 (17%) 2 (29%) 4 (10%)
Skin (35) (22) (18) (46)
Subcutaneous Tissue, Fibrosarcoma 1 (5%) 1 (6%)
Subcutaneous Tissue, Hemangiosarcoma 1 (6%)
Subcutaneous Tissue, Myxosarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (5%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (1)
Sarcoma, Metastatic, Skin 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (35) (15) (6) (48)
Adenocarcinoma, Metastatic, Mammary Gland 1 (3%) 1 (2%)
Alveolar/Bronchiolar Adenoma 1 (3%) 2 (13%) 1 (17%) 2 (4%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (7%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (3%)
Hepatocellular Carcinoma, Metastatic 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (29) (12) (4) (23)
Adenoma 2 (7%) 1 (8%) 1 (25%) 3 (13%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (34) (15) (8) (48)
Urinary Bladder (34) (12) (5) (47)
Page 4
NTP Experiment-Test: 05074-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DOWICIDE EC-7 PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 06:47:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 100 PPM 200 PPM 600 PPM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(35) *(50) *(50) *(49)
Lymphoma Malignant 1 (2%)
Lymphoma Malignant Histiocytic 1 (3%) 1 (2%) 3 (6%) 2 (4%)
Lymphoma Malignant Lymphocytic 11 (31%) 4 (8%) 4 (8%) 11 (22%)
Lymphoma Malignant Mixed 3 (9%) 11 (22%) 6 (12%) 3 (6%)
Lymphoma Malignant Undifferentiated Cell 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05074-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DOWICIDE EC-7 PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 06:47:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 100 PPM 200 PPM 600 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 24 29 25 46
Total Primary Neoplasms 39 42 37 122
Total Animals with Benign Neoplasms 13 12 13 44
Total Benign Neoplasms 19 15 15 84
Total Animals with Malignant Neoplasms 18 24 18 31
Total Malignant Neoplasms 20 27 22 38
Total Animals with Metastatic Neoplasms 1 1 3 4
Total Metastatic Neoplasm 1 1 4 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05074-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DOWICIDE EC-7 PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 06:47:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 100 PPM 200 PPM 600 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 35 50 50 50
Early Deaths
Moribund Sacrifice 2 3 4 6
Natural Death 8 19 17 9
Survivors
Terminal Sacrifice 25 28 29 35
Animals Examined Microscopically 35 50 50 49
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Jejunum (32) (6) (12) (47)
Liver (35) (48) (48) (49)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Hemangioma 1 (3%) 1 (2%) 1 (2%)
Hemangioma, Multiple 1 (2%)
Hemangiosarcoma 1 (2%) 2 (4%) 2 (4%)
Hemangiosarcoma, Multiple 2 (4%) 1 (2%)
Hepatocellular Carcinoma 1 (3%) 6 (13%) 6 (13%) 8 (16%)
Hepatocellular Carcinoma, Multiple 1 (2%) 1 (2%) 1 (2%)
Hepatocellular Adenoma 5 (14%) 10 (21%) 9 (19%) 10 (20%)
Hepatocellular Adenoma, Multiple 3 (6%) 8 (17%) 22 (45%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Gland 1 (2%)
Pancreas (34) (12) (14) (49)
Salivary Glands (35) (11) (15) (49)
Stomach, Glandular (33) (11) (15) (49)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (35) (13) (17) (49)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (34) (48) (49) (49)
Capsule, Adenoma 1 (2%)
Adrenal Gland, Cortex (34) (48) (48) (49)
Adenoma 1 (3%)
Adrenal Gland, Medulla (34) (48) (48) (49)
Pheochromocytoma Malignant 1 (3%) 2 (4%)
Pheochromocytoma Benign 4 (8%) 4 (8%) 5 (10%)
Bilateral, Pheochromocytoma Malignant 1 (2%)
Page 7
NTP Experiment-Test: 05074-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DOWICIDE EC-7 PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 06:47:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 100 PPM 200 PPM 600 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Bilateral, Pheochromocytoma Benign 17 (35%) 39 (80%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (35) (13) (18) (49)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (35) (10) (14) (49)
Lymph Node (31) (14) (22) (47)
Lymph Node, Mandibular (31) (8) (13) (47)
Spleen (34) (19) (20) (49)
Hemangiosarcoma 1 (5%) 1 (5%)
Hemangiosarcoma, Multiple 1 (5%)
Thymus (21) (5) (11) (27)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (34) (32) (26) (49)
Papilloma, Multiple 1 (3%)
Squamous Cell Papilloma 1 (2%)
Sebaceous Gland, Carcinoma 1 (3%)
Subcutaneous Tissue, Fibroma 2 (6%) 1 (4%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 4 (12%) 4 (13%) 6 (23%) 6 (12%)
Subcutaneous Tissue, Fibrosarcoma, Multiple 2 (6%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
Intercostal, Fibrosarcoma, Metastatic, Skin 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05074-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DOWICIDE EC-7 PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 06:47:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 100 PPM 200 PPM 600 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (35) (15) (19) (49)
Alveolar/Bronchiolar Adenoma 5 (14%) 1 (7%) 1 (5%) 4 (8%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (5%)
Fibrosarcoma, Metastatic, Skin 1 (3%) 1 (5%)
Hepatocellular Carcinoma, Metastatic 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Gland 1 (3%) 2 (4%)
Interstitium, Mediastinum, Fibrosarcoma,
Multiple, Metastatic, Skin 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (27) (12) (13) (35)
Adenoma 2 (7%) 1 (8%) 3 (9%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (35) (14) (20) (49)
Renal Tubule, Adenoma 1 (5%) 1 (2%)
Urinary Bladder (33) (11) (15) (49)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(35) *(50) *(50) *(49)
Lymphoma Malignant Histiocytic 1 (3%) 2 (4%) 1 (2%) 2 (4%)
Lymphoma Malignant Lymphocytic 3 (9%)
Lymphoma Malignant Mixed 2 (6%) 2 (4%) 3 (6%) 3 (6%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 9
NTP Experiment-Test: 05074-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DOWICIDE EC-7 PENTACHLOROPHENOL Date: 09/09/94
Route: DOSED FEED Time: 06:47:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 100 PPM 200 PPM 600 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 20 32 33 46
Total Primary Neoplasms 26 46 63 116
Total Animals with Benign Neoplasms 11 21 28 45
Total Benign Neoplasms 14 23 42 89
Total Animals with Malignant Neoplasms 10 22 16 22
Total Malignant Neoplasms 12 23 21 27
Total Animals with Metastatic Neoplasms 2 2 1 3
Total Metastatic Neoplasm 2 3 1 5
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 10
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------
--multipart-boundary
Content-type: text/plain
Range: bytes 56356-56356/56356
--multipart-boundary--