TR 349 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus DOWICIDE EC-7 PENTACHLOROPHENOL DATE: 09/09/94
EXPERIMENT: 05074 TEST: 01 TIME: 06:57:58
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-38068 ROUTE: DOSED FEED NTP C#: 55389
PATHOLOGIST: R. PERSING S. EUSTIS CAS: 87-86-5
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus DOWICIDE EC-7 PENTACHLOROPHENOL DATE: 09/09/94
EXPERIMENT: 05074 TEST: 01 TIME: 06:57:58
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-38068 ROUTE: DOSED FEED NTP C#: 55389
PATHOLOGIST: R. PERSING S. EUSTIS CAS: 87-86-5
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus DOWICIDE EC-7 PENTACHLOROPHENOL DATE: 09/09/94
EXPERIMENT: 05074 TEST: 01 TIME: 06:57:58
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-38068 ROUTE: DOSED FEED NTP C#: 55389
PATHOLOGIST: R. PERSING S. EUSTIS CAS: 87-86-5
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF DOWICIDE EC-7 PENTACHLOROPHENOL
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Benign
Pheochromocytoma: Benign, Complex, Malignant, NOS
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Spleen Hemangiosarcoma
All Organs Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Benign
Pheochromocytoma: Benign, Complex, Malignant, NOS
Islets, Pancreatic Carcinoma
Liver Hemangiosarcoma
Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
All Organs Hemangiosarcoma
Hemangiosarcoma or Hemangioma
Benign Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/09/94 EXPERIMENT: 05074 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DOWICIDE EC-7 PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 200 PPM 600 PPM | 0 PPM 100 PPM 200 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Gland: Non-medullary, Non-cortical |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/34 (0%) 1/48 (2%) 0/49 (0%) 0/49 (0%) | 0/35 (0%) 2/50 (4%) 0/47 (0%) 0/49 (0%) |
|ADJUSTED (b) | 0.0% 3.6% 0.0% 0.0% | 0.0% 7.1% 0.0% 0.0% |
|TERMINAL (d) | 0/25 (0%) 1/28 (4%) 0/29 (0%) 0/35 (0%) | 0/29 (0%) 2/28 (7%) 0/38 (0%) 0/39 (0%) |
|FIRST INCIDENCE (DAYS) | --- 727 (T) --- --- | --- 727 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.579N P=0.523 (e) (e) | P=0.375N P=0.230 (e) (e) |
|INCIDENTAL TUMOR | P=0.579N P=0.523 (e) (e) | P=0.375N P=0.230 (e) (e) |
|LOGISTIC REGRESSION | P=0.579N P=0.523 (e) (e) | P=0.375N P=0.230 (e) (e) |
|COCHRAN-ARMITAGE | P=0.597N | P=0.397N |
|FISHER EXACT | P=0.585 (e) (e) | P=0.343 (e) (e) |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/34 (0%) 4/48 (8%) 21/48 (44%) 44/49 (90%) | 0/35 (0%) 1/49 (2%) 2/46 (4%) 38/49 (78%) |
|ADJUSTED (b) | 0.0% 13.8% 67.5% 97.8% | 0.0% 3.6% 5.3% 86.3% |
|TERMINAL (d) | 0/25 (0%) 3/28 (11%) 19/29 (66%) 34/35 (97%) | 0/29 (0%) 1/28 (4%) 2/38 (5%) 33/39 (85%) |
|FIRST INCIDENCE (DAYS) | --- 723 598 458 | --- 727 (T) 727 (T) 555 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.081 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.493 P=0.299 P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.107 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.493 P=0.299 P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.079 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.493 P=0.299 P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.111 P<0.001 ** P<0.001 ** | P=0.583 P=0.319 P<0.001 ** |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05074 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DOWICIDE EC-7 PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 200 PPM 600 PPM | 0 PPM 100 PPM 200 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/34 (3%) 0/48 (0%) 0/48 (0%) 3/49 (6%) | 0/35 (0%) 1/49 (2%) 0/46 (0%) 1/49 (2%) |
|ADJUSTED (b) | 4.0% 0.0% 0.0% 8.6% | 0.0% 3.6% 0.0% 2.6% |
|TERMINAL (d) | 1/25 (4%) 0/28 (0%) 0/29 (0%) 3/35 (9%) | 0/29 (0%) 1/28 (4%) 0/38 (0%) 1/39 (3%) |
|FIRST INCIDENCE (DAYS) | 727 (T) --- --- 727 (T) | --- 727 (T) --- 727 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.104 P=0.477N P=0.470N P=0.431 | P=0.505 P=0.493 (e) P=0.559 |
|INCIDENTAL TUMOR | P=0.104 P=0.477N P=0.470N P=0.431 | P=0.505 P=0.493 (e) P=0.559 |
|LOGISTIC REGRESSION | P=0.104 P=0.477N P=0.470N P=0.431 | P=0.505 P=0.493 (e) P=0.559 |
|COCHRAN-ARMITAGE | P=0.084 | P=0.483 |
|FISHER EXACT | P=0.415N P=0.415N P=0.456 | P=0.583 (e) P=0.583 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/34 (3%) 4/48 (8%) 21/48 (44%) 45/49 (92%) | 0/35 (0%) 2/49 (4%) 2/46 (4%) 38/49 (78%) |
|ADJUSTED (b) | 4.0% 13.8% 67.5% 100.0% | 0.0% 7.1% 5.3% 86.3% |
|TERMINAL (d) | 1/25 (4%) 3/28 (11%) 19/29 (66%) 35/35 (100%)| 0/29 (0%) 2/28 (7%) 2/38 (5%) 33/39 (85%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 723 598 458 | --- 727 (T) 727 (T) 555 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.218 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.230 P=0.299 P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.268 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.230 P=0.299 P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.219 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.230 P=0.299 P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.305 P<0.001 ** P<0.001 ** | P=0.337 P=0.319 P<0.001 ** |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05074 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DOWICIDE EC-7 PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 200 PPM 600 PPM | 0 PPM 100 PPM 200 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/35 (6%) 1/50 (2%) 0/50 (0%) 3/49 (6%) | 2/35 (6%) 1/50 (2%) 1/50 (2%) 3/49 (6%) |
|ADJUSTED (b) | 8.0% 3.6% 0.0% 7.9% | 6.9% 3.6% 2.6% 7.7% |
|TERMINAL (d) | 2/25 (8%) 1/28 (4%) 0/29 (0%) 2/35 (6%) | 2/29 (7%) 1/28 (4%) 1/38 (3%) 3/39 (8%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 727 (T) --- 604 | 727 (T) 727 (T) 727 (T) 727 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.375 P=0.460N P=0.206N P=0.658 | P=0.412 P=0.512N P=0.406N P=0.634 |
|INCIDENTAL TUMOR | P=0.390 P=0.460N P=0.206N P=0.569N | P=0.412 P=0.512N P=0.406N P=0.634 |
|LOGISTIC REGRESSION | P=0.354 P=0.460N P=0.206N P=0.660 | P=0.412 P=0.512N P=0.406N P=0.634 |
|COCHRAN-ARMITAGE | P=0.322 | P=0.360 |
|FISHER EXACT | P=0.367N P=0.167N P=0.657 | P=0.367N P=0.367N P=0.657 |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/34 (0%) 0/11 (0%) 0/14 (0%) 0/49 (0%) | 0/34 (0%) 2/16 (13%) 0/5 (0%) 0/46 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 100.0% 0.0% 0.0% |
|TERMINAL (d) | 0/25 (0%) 0/0 0/0 0/35 (0%) | 0/29 (0%) 2/2 (100%) 0/0 0/39 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- 727 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.254N P<0.001 ** (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.254N P<0.001 ** (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.254N P<0.001 ** (e) (e) |
|COCHRAN-ARMITAGE | (e) | P=0.306N |
|FISHER EXACT | (e) (e) (e) | P=0.098 (e) (e) |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05074 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DOWICIDE EC-7 PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 200 PPM 600 PPM | 0 PPM 100 PPM 200 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/35 (3%) 0/48 (0%) 1/48 (2%) 2/49 (4%) | 0/34 (0%) 0/50 (0%) 0/49 (0%) 1/48 (2%) |
|ADJUSTED (b) | 4.0% 0.0% 3.4% 5.7% | 0.0% 0.0% 0.0% 2.6% |
|TERMINAL (d) | 1/25 (4%) 0/28 (0%) 1/29 (3%) 2/35 (6%) | 0/29 (0%) 0/28 (0%) 0/38 (0%) 1/39 (3%) |
|FIRST INCIDENCE (DAYS) | 727 (T) --- 727 (T) 727 (T) | --- --- --- 727 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.344 P=0.477N P=0.729N P=0.617 | P=0.264 (e) (e) P=0.559 |
|INCIDENTAL TUMOR | P=0.344 P=0.477N P=0.729N P=0.617 | P=0.264 (e) (e) P=0.559 |
|LOGISTIC REGRESSION | P=0.344 P=0.477N P=0.729N P=0.617 | P=0.264 (e) (e) P=0.559 |
|COCHRAN-ARMITAGE | P=0.308 | P=0.240 |
|FISHER EXACT | P=0.422N P=0.669N P=0.625 | (e) (e) P=0.585 |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/35 (0%) 3/48 (6%) 2/48 (4%) 3/49 (6%) | 0/34 (0%) 1/50 (2%) 1/49 (2%) 8/48 (17%) |
|ADJUSTED (b) | 0.0% 9.7% 6.7% 8.6% | 0.0% 3.6% 2.3% 18.9% |
|TERMINAL (d) | 0/25 (0%) 2/28 (7%) 1/29 (3%) 3/35 (9%) | 0/29 (0%) 1/28 (4%) 0/38 (0%) 5/39 (13%) |
|FIRST INCIDENCE (DAYS) | --- 655 690 727 (T) | --- 727 (T) 699 611 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.333 P=0.152 P=0.268 P=0.186 | P<0.001 ** P=0.493 P=0.559 P=0.016 * |
|INCIDENTAL TUMOR | P=0.287 P=0.194 P=0.256 P=0.186 | P<0.001 ** P=0.493 P=0.581 P=0.023 * |
|LOGISTIC REGRESSION | P=0.320 P=0.173 P=0.274 P=0.186 | P<0.001 ** P=0.493 P=0.579 P=0.017 * |
|COCHRAN-ARMITAGE | P=0.288 | P<0.001 ** |
|FISHER EXACT | P=0.188 P=0.331 P=0.193 | P=0.595 P=0.590 P=0.011 * |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05074 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DOWICIDE EC-7 PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 200 PPM 600 PPM | 0 PPM 100 PPM 200 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/35 (14%) 13/48 (27%) 17/48 (35%) 32/49 (65%) | 1/34 (3%) 3/50 (6%) 6/49 (12%) 30/48 (63%) |
|ADJUSTED (b) | 20.0% 41.6% 53.0% 84.1% | 3.4% 10.7% 15.8% 75.0% |
|TERMINAL (d) | 5/25 (20%) 10/28 (36%) 14/29 (48%) 29/35 (83%) | 1/29 (3%) 3/28 (11%) 6/38 (16%) 29/39 (74%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 613 608 536 | 727 (T) 727 (T) 727 (T) 668 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.057 P=0.008 ** P<0.001 ** | P<0.001 ** P=0.291 P=0.110 P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.114 P=0.011 * P<0.001 ** | P<0.001 ** P=0.291 P=0.110 P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.083 P=0.007 ** P<0.001 ** | P<0.001 ** P=0.289 P=0.110 P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.129 P=0.027 * P<0.001 ** | P=0.465 P=0.135 P<0.001 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/35 (3%) 7/48 (15%) 7/48 (15%) 9/49 (18%) | 0/34 (0%) 1/50 (2%) 0/49 (0%) 2/48 (4%) |
|ADJUSTED (b) | 4.0% 20.2% 24.1% 25.0% | 0.0% 3.4% 0.0% 5.1% |
|TERMINAL (d) | 1/25 (4%) 2/28 (7%) 7/29 (24%) 8/35 (23%) | 0/29 (0%) 0/28 (0%) 0/38 (0%) 2/39 (5%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 612 727 (T) 717 | --- 720 --- 727 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.127 P=0.062 P=0.047 * P=0.034 * | P=0.194 P=0.487 (e) P=0.306 |
|INCIDENTAL TUMOR | P=0.088 P=0.186 P=0.047 * P=0.033 * | P=0.172 P=0.612 (e) P=0.306 |
|LOGISTIC REGRESSION | P=0.108 P=0.075 P=0.047 * P=0.032 * | P=0.179 P=0.518 (e) P=0.306 |
|COCHRAN-ARMITAGE | P=0.080 | P=0.165 |
|FISHER EXACT | P=0.075 P=0.075 P=0.029 * | P=0.595 (e) P=0.340 |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05074 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DOWICIDE EC-7 PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 200 PPM 600 PPM | 0 PPM 100 PPM 200 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/35 (17%) 19/48 (40%) 21/48 (44%) 34/49 (69%) | 1/34 (3%) 4/50 (8%) 6/49 (12%) 31/48 (65%) |
|ADJUSTED (b) | 24.0% 53.8% 65.5% 87.1% | 3.4% 13.8% 15.8% 77.5% |
|TERMINAL (d) | 6/25 (24%) 12/28 (43%) 18/29 (62%) 30/35 (86%) | 1/29 (3%) 3/28 (11%) 6/38 (16%) 30/39 (77%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 612 608 536 | 727 (T) 720 727 (T) 668 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.009 ** P=0.002 ** P<0.001 ** | P<0.001 ** P=0.168 P=0.110 P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.039 * P=0.002 ** P<0.001 ** | P<0.001 ** P=0.204 P=0.110 P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.015 * P=0.001 ** P<0.001 ** | P<0.001 ** P=0.172 P=0.110 P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.024 * P=0.009 ** P<0.001 ** | P=0.322 P=0.135 P<0.001 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/35 (17%) 19/48 (40%) 21/48 (44%) 34/49 (69%) | 1/34 (3%) 4/50 (8%) 6/49 (12%) 31/48 (65%) |
|ADJUSTED (b) | 24.0% 53.8% 65.5% 87.1% | 3.4% 13.8% 15.8% 77.5% |
|TERMINAL (d) | 6/25 (24%) 12/28 (43%) 18/29 (62%) 30/35 (86%) | 1/29 (3%) 3/28 (11%) 6/38 (16%) 30/39 (77%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 612 608 536 | 727 (T) 720 727 (T) 668 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.009 ** P=0.002 ** P<0.001 ** | P<0.001 ** P=0.168 P=0.110 P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.039 * P=0.002 ** P<0.001 ** | P<0.001 ** P=0.204 P=0.110 P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.015 * P=0.001 ** P<0.001 ** | P<0.001 ** P=0.172 P=0.110 P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.024 * P=0.009 ** P<0.001 ** | P=0.322 P=0.135 P<0.001 ** |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05074 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DOWICIDE EC-7 PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 200 PPM 600 PPM | 0 PPM 100 PPM 200 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/35 (14%) 1/15 (7%) 1/19 (5%) 5/49 (10%) | 1/35 (3%) 3/15 (20%) 1/6 (17%) 2/48 (4%) |
|ADJUSTED (b) | 19.2% 2.6% 50.0% 14.3% | 3.4% 100.0% 2.2% 5.0% |
|TERMINAL (d) | 4/25 (16%) 0/2 (0%) 1/2 (50%) 5/35 (14%) | 1/29 (3%) 1/1 (100%) 0/1 (0%) 1/39 (3%) |
|FIRST INCIDENCE (DAYS) | 710 612 727 (T) 727 (T) | 727 (T) 454 636 712 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.340N P=0.547N P=0.706 P=0.409N | P=0.447N P=0.040 * P=0.582 P=0.594 |
|INCIDENTAL TUMOR | P=0.291N P=0.660N P=0.405 P=0.413N | P=0.479N P=0.098 P=0.776 P=0.594 |
|LOGISTIC REGRESSION | P=0.287N P=0.688 P=0.476 P=0.404N | P=0.453N P=0.127 P=0.444 P=0.593 |
|COCHRAN-ARMITAGE | P=0.487N | P=0.379N |
|FISHER EXACT | P=0.409N P=0.302N P=0.405N | P=0.075 P=0.274 P=0.618 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/35 (14%) 1/15 (7%) 2/19 (11%) 5/49 (10%) | 2/35 (6%) 3/15 (20%) 1/6 (17%) 3/48 (6%) |
|ADJUSTED (b) | 19.2% 2.6% 100.0% 14.3% | 6.9% 100.0% 2.2% 7.5% |
|TERMINAL (d) | 4/25 (16%) 0/2 (0%) 2/2 (100%) 5/35 (14%) | 2/29 (7%) 1/1 (100%) 0/1 (0%) 2/39 (5%) |
|FIRST INCIDENCE (DAYS) | 710 612 727 (T) 727 (T) | 727 (T) 454 636 712 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.293N P=0.547N P=0.244 P=0.409N | P=0.416N P=0.048 * P=0.601 P=0.626 |
|INCIDENTAL TUMOR | P=0.249N P=0.660N P=0.034 * P=0.413N | P=0.442N P=0.120 P=0.782 P=0.626 |
|LOGISTIC REGRESSION | P=0.244N P=0.688 P=0.054 P=0.404N | P=0.428N P=0.185 P=0.506 P=0.615 |
|COCHRAN-ARMITAGE | P=0.446N | P=0.389N |
|FISHER EXACT | P=0.409N P=0.526N P=0.405N | P=0.152 P=0.386 P=0.648 |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05074 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DOWICIDE EC-7 PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 200 PPM 600 PPM | 0 PPM 100 PPM 200 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/35 (0%) 0/50 (0%) 0/50 (0%) 0/49 (0%) | 3/35 (9%) 1/50 (2%) 2/50 (4%) 4/49 (8%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 10.3% 2.8% 5.1% 9.3% |
|TERMINAL (d) | 0/25 (0%) 0/28 (0%) 0/29 (0%) 0/35 (0%) | 3/29 (10%) 0/28 (0%) 1/38 (3%) 2/39 (5%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 727 (T) 643 710 528 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.388 P=0.310N P=0.383N P=0.648N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.322 P=0.171N P=0.354N P=0.602N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.333 P=0.226N P=0.369N P=0.590N |
|COCHRAN-ARMITAGE | (e) | P=0.340 |
|FISHER EXACT | (e) (e) (e) | P=0.187N P=0.334N P=0.622N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/29 (0%) 0/9 (0%) 0/14 (0%) 0/38 (0%) | 10/32 (31%) 3/17 (18%) 4/9 (44%) 6/44 (14%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 33.2% 75.0% 80.0% 16.2% |
|TERMINAL (d) | 0/22 (0%) 0/0 0/0 0/28 (0%) | 8/28 (29%) 3/4 (75%) 4/5 (80%) 6/37 (16%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 720 727 (T) 727 (T) 727 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.024N* P=0.442 P=0.321 P=0.075N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.015N* P=0.106 P=0.047 * P=0.062N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.021N* P=0.154 P=0.077 P=0.078N |
|COCHRAN-ARMITAGE | (e) | P=0.055N |
|FISHER EXACT | (e) (e) (e) | P=0.250N P=0.360 P=0.058N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05074 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DOWICIDE EC-7 PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 200 PPM 600 PPM | 0 PPM 100 PPM 200 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/35 (0%) 2/50 (4%) 1/50 (2%) 1/49 (2%) | 0/35 (0%) 0/50 (0%) 0/50 (0%) 0/49 (0%) |
|ADJUSTED (b) | 0.0% 7.1% 3.4% 2.7% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/25 (0%) 2/28 (7%) 1/29 (3%) 0/35 (0%) | 0/29 (0%) 0/28 (0%) 0/38 (0%) 0/39 (0%) |
|FIRST INCIDENCE (DAYS) | --- 727 (T) 727 (T) 711 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.652N P=0.263 P=0.530 P=0.578 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.644 P=0.263 P=0.530 P=0.557 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.662N P=0.263 P=0.530 P=0.572 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.644 | (e) |
|FISHER EXACT | P=0.343 P=0.588 P=0.583 | (e) (e) (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/35 (11%) 6/50 (12%) 6/50 (12%) 6/49 (12%) | 0/35 (0%) 1/50 (2%) 1/50 (2%) 0/49 (0%) |
|ADJUSTED (b) | 14.6% 20.1% 18.0% 14.2% | 0.0% 3.6% 2.6% 0.0% |
|TERMINAL (d) | 2/25 (8%) 5/28 (18%) 3/29 (10%) 1/35 (3%) | 0/29 (0%) 1/28 (4%) 1/38 (3%) 0/39 (0%) |
|FIRST INCIDENCE (DAYS) | 681 613 578 379 | --- 727 (T) 727 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.523N P=0.456 P=0.469 P=0.593 | P=0.495N P=0.493 P=0.554 (e) |
|INCIDENTAL TUMOR | P=0.569 P=0.599N P=0.441N P=0.589 | P=0.495N P=0.493 P=0.554 (e) |
|LOGISTIC REGRESSION | P=0.564 P=0.554 P=0.438N P=0.587 | P=0.495N P=0.493 P=0.554 (e) |
|COCHRAN-ARMITAGE | P=0.543 | P=0.522N |
|FISHER EXACT | P=0.608 P=0.608 P=0.595 | P=0.588 P=0.588 (e) |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05074 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DOWICIDE EC-7 PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 200 PPM 600 PPM | 0 PPM 100 PPM 200 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/35 (11%) 8/50 (16%) 7/50 (14%) 8/49 (16%) | 0/35 (0%) 2/50 (4%) 1/50 (2%) 0/49 (0%) |
|ADJUSTED (b) | 14.6% 27.0% 21.1% 18.6% | 0.0% 5.5% 2.6% 0.0% |
|TERMINAL (d) | 2/25 (8%) 7/28 (25%) 4/29 (14%) 1/35 (3%) | 0/29 (0%) 1/28 (4%) 1/38 (3%) 0/39 (0%) |
|FIRST INCIDENCE (DAYS) | 681 613 578 379 | --- 443 727 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.501 P=0.248 P=0.359 P=0.396 | P=0.357N P=0.272 P=0.554 (e) |
|INCIDENTAL TUMOR | P=0.432 P=0.423 P=0.583N P=0.454 | P=0.362N P=0.402 P=0.554 (e) |
|LOGISTIC REGRESSION | P=0.427 P=0.327 P=0.594N P=0.373 | P=0.413N P=0.485 P=0.554 (e) |
|COCHRAN-ARMITAGE | P=0.397 | P=0.375N |
|FISHER EXACT | P=0.396 P=0.498 P=0.381 | P=0.343 P=0.588 (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/35 (11%) 6/50 (12%) 6/50 (12%) 7/49 (14%) | 0/35 (0%) 2/50 (4%) 1/50 (2%) 0/49 (0%) |
|ADJUSTED (b) | 14.6% 20.1% 18.0% 16.4% | 0.0% 5.5% 2.6% 0.0% |
|TERMINAL (d) | 2/25 (8%) 5/28 (18%) 3/29 (10%) 1/35 (3%) | 0/29 (0%) 1/28 (4%) 1/38 (3%) 0/39 (0%) |
|FIRST INCIDENCE (DAYS) | 681 613 578 379 | --- 443 727 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.495 P=0.456 P=0.469 P=0.489 | P=0.357N P=0.272 P=0.554 (e) |
|INCIDENTAL TUMOR | P=0.439 P=0.599N P=0.441N P=0.589 | P=0.362N P=0.402 P=0.554 (e) |
|LOGISTIC REGRESSION | P=0.374 P=0.554 P=0.438N P=0.474 | P=0.413N P=0.485 P=0.554 (e) |
|COCHRAN-ARMITAGE | P=0.403 | P=0.375N |
|FISHER EXACT | P=0.608 P=0.608 P=0.484 | P=0.343 P=0.588 (e) |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05074 TEST: 01 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DOWICIDE EC-7 PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 200 PPM 600 PPM | 0 PPM 100 PPM 200 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/34 (0%) 2/19 (11%) 1/20 (5%) 0/49 (0%) | 0/34 (0%) 0/26 (0%) 2/17 (12%) 2/47 (4%) |
|ADJUSTED (b) | 0.0% 33.3% 20.0% 0.0% | 0.0% 0.0% 12.3% 4.7% |
|TERMINAL (d) | 0/25 (0%) 2/6 (33%) 1/5 (20%) 0/35 (0%) | 0/29 (0%) 0/5 (0%) 1/10 (10%) 0/39 (0%) |
|FIRST INCIDENCE (DAYS) | --- 727 (T) 727 (T) --- | --- --- 711 611 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.231N P=0.021 * P=0.186 (e) | P=0.233 (e) P=0.147 P=0.297 |
|INCIDENTAL TUMOR | P=0.231N P=0.021 * P=0.186 (e) | P=0.128 (e) P=0.108 P=0.500 |
|LOGISTIC REGRESSION | P=0.231N P=0.021 * P=0.186 (e) | P=0.281 (e) P=0.079 P=0.351 |
|COCHRAN-ARMITAGE | P=0.275N | P=0.281 |
|FISHER EXACT | P=0.124 P=0.370 (e) | (e) P=0.107 P=0.334 |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/35 (0%) 0/11 (0%) 0/14 (0%) 0/48 (0%) | 3/34 (9%) 0/14 (0%) 0/4 (0%) 3/46 (7%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 10.3% 0.0% 0.0% 7.5% |
|TERMINAL (d) | 0/25 (0%) 0/0 0/0 0/34 (0%) | 3/29 (10%) 0/0 0/0 2/38 (5%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 727 (T) --- --- 670 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.531N (e) (e) P=0.535N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.480N (e) (e) P=0.537N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.522N (e) (e) P=0.526N |
|COCHRAN-ARMITAGE | (e) | P=0.603N |
|FISHER EXACT | (e) (e) (e) | P=0.346N P=0.709N P=0.509N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05074 TEST: 01 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DOWICIDE EC-7 PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 200 PPM 600 PPM | 0 PPM 100 PPM 200 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/35 (3%) 0/50 (0%) 1/50 (2%) 2/49 (4%) | 0/35 (0%) 0/50 (0%) 0/50 (0%) 1/49 (2%) |
|ADJUSTED (b) | 4.0% 0.0% 3.4% 5.7% | 0.0% 0.0% 0.0% 2.6% |
|TERMINAL (d) | 1/25 (4%) 0/28 (0%) 1/29 (3%) 2/35 (6%) | 0/29 (0%) 0/28 (0%) 0/38 (0%) 1/39 (3%) |
|FIRST INCIDENCE (DAYS) | 727 (T) --- 727 (T) 727 (T) | --- --- --- 727 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.344 P=0.477N P=0.729N P=0.617 | P=0.264 (e) (e) P=0.559 |
|INCIDENTAL TUMOR | P=0.344 P=0.477N P=0.729N P=0.617 | P=0.264 (e) (e) P=0.559 |
|LOGISTIC REGRESSION | P=0.344 P=0.477N P=0.729N P=0.617 | P=0.264 (e) (e) P=0.559 |
|COCHRAN-ARMITAGE | P=0.300 | P=0.241 |
|FISHER EXACT | P=0.412N P=0.657N P=0.625 | (e) (e) P=0.583 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/35 (0%) 4/50 (8%) 2/50 (4%) 3/49 (6%) | 0/35 (0%) 1/50 (2%) 3/50 (6%) 8/49 (16%) |
|ADJUSTED (b) | 0.0% 13.2% 6.7% 8.6% | 0.0% 3.6% 7.3% 18.9% |
|TERMINAL (d) | 0/25 (0%) 3/28 (11%) 1/29 (3%) 3/35 (9%) | 0/29 (0%) 1/28 (4%) 1/38 (3%) 5/39 (13%) |
|FIRST INCIDENCE (DAYS) | --- 655 690 727 (T) | --- 727 (T) 699 611 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.425 P=0.084 P=0.268 P=0.186 | P=0.002 ** P=0.493 P=0.173 P=0.016 * |
|INCIDENTAL TUMOR | P=0.380 P=0.107 P=0.256 P=0.186 | P<0.001 ** P=0.493 P=0.209 P=0.017 * |
|LOGISTIC REGRESSION | P=0.411 P=0.101 P=0.277 P=0.186 | P<0.001 ** P=0.493 P=0.190 P=0.016 * |
|COCHRAN-ARMITAGE | P=0.365 | P<0.001 ** |
|FISHER EXACT | P=0.114 P=0.343 P=0.193 | P=0.588 P=0.198 P=0.010 * |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05074 TEST: 01 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DOWICIDE EC-7 PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 200 PPM 600 PPM | 0 PPM 100 PPM 200 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/35 (3%) 4/50 (8%) 3/50 (6%) 5/49 (10%) | 0/35 (0%) 1/50 (2%) 3/50 (6%) 9/49 (18%) |
|ADJUSTED (b) | 4.0% 13.2% 10.0% 14.3% | 0.0% 3.6% 7.3% 21.3% |
|TERMINAL (d) | 1/25 (4%) 3/28 (11%) 2/29 (7%) 5/35 (14%) | 0/29 (0%) 1/28 (4%) 1/38 (3%) 6/39 (15%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 655 690 727 (T) | --- 727 (T) 699 611 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.264 P=0.224 P=0.356 P=0.193 | P<0.001 ** P=0.493 P=0.173 P=0.010 ** |
|INCIDENTAL TUMOR | P=0.230 P=0.268 P=0.346 P=0.193 | P<0.001 ** P=0.493 P=0.209 P=0.010 * |
|LOGISTIC REGRESSION | P=0.250 P=0.264 P=0.361 P=0.193 | P<0.001 ** P=0.493 P=0.190 P=0.010 ** |
|COCHRAN-ARMITAGE | P=0.200 | P<0.001 ** |
|FISHER EXACT | P=0.310 P=0.453 P=0.199 | P=0.588 P=0.198 P=0.006 ** |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 6/35 (17%) 4/50 (8%) 4/50 (8%) 5/49 (10%) | 15/35 (43%) 18/50 (36%) 13/50 (26%) 16/49 (33%) |
|ADJUSTED (b) | 23.1% 12.9% 12.4% 13.5% | 48.2% 46.7% 32.0% 38.8% |
|TERMINAL (d) | 5/25 (20%) 2/28 (7%) 2/29 (7%) 4/35 (11%) | 13/29 (45%) 9/28 (32%) 11/38 (29%) 14/39 (36%) |
|FIRST INCIDENCE (DAYS) | 710 690 541 608 | 685 454 514 653 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.345N P=0.296N P=0.278N P=0.271N | P=0.200N P=0.358 P=0.137N P=0.292N |
|INCIDENTAL TUMOR | P=0.422N P=0.166N P=0.355N P=0.183N | P=0.253N P=0.412N P=0.121N P=0.288N |
|LOGISTIC REGRESSION | P=0.372N P=0.226N P=0.248N P=0.257N | P=0.290N P=0.381N P=0.088N P=0.307N |
|COCHRAN-ARMITAGE | P=0.422N | P=0.300N |
|FISHER EXACT | P=0.172N P=0.172N P=0.272N | P=0.339N P=0.082N P=0.234N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05074 TEST: 01 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DOWICIDE EC-7 PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 200 PPM 600 PPM | 0 PPM 100 PPM 200 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 6/35 (17%) 4/50 (8%) 4/50 (8%) 5/49 (10%) | 15/35 (43%) 18/50 (36%) 13/50 (26%) 16/49 (33%) |
|ADJUSTED (b) | 23.1% 12.9% 12.4% 13.5% | 48.2% 46.7% 32.0% 38.8% |
|TERMINAL (d) | 5/25 (20%) 2/28 (7%) 2/29 (7%) 4/35 (11%) | 13/29 (45%) 9/28 (32%) 11/38 (29%) 14/39 (36%) |
|FIRST INCIDENCE (DAYS) | 710 690 541 608 | 685 454 514 653 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.345N P=0.296N P=0.278N P=0.271N | P=0.200N P=0.358 P=0.137N P=0.292N |
|INCIDENTAL TUMOR | P=0.422N P=0.166N P=0.355N P=0.183N | P=0.253N P=0.412N P=0.121N P=0.288N |
|LOGISTIC REGRESSION | P=0.372N P=0.226N P=0.248N P=0.257N | P=0.290N P=0.381N P=0.088N P=0.307N |
|COCHRAN-ARMITAGE | P=0.422N | P=0.300N |
|FISHER EXACT | P=0.172N P=0.172N P=0.272N | P=0.339N P=0.082N P=0.234N |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 11/35 (31%) 21/50 (42%) 28/50 (56%) 45/49 (92%) | 13/35 (37%) 12/50 (24%) 13/50 (26%) 44/49 (90%) |
|ADJUSTED (b) | 42.3% 65.2% 84.8% 100.0% | 41.9% 38.6% 32.1% 97.8% |
|TERMINAL (d) | 10/25 (40%) 17/28 (61%) 24/29 (83%) 35/35 (100%)| 11/29 (38%) 10/28 (36%) 11/38 (29%) 38/39 (97%) |
|FIRST INCIDENCE (DAYS) | 710 612 598 458 | 720 454 636 555 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.052 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.517N P=0.283N P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.147 P=0.001 ** P<0.001 ** | P<0.001 ** P=0.338N P=0.211N P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.097 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.284N P=0.234N P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.223 P=0.021 * P<0.001 ** | P=0.143N P=0.195N P<0.001 ** |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05074 TEST: 01 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DOWICIDE EC-7 PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 200 PPM 600 PPM | 0 PPM 100 PPM 200 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 10/35 (29%) 22/50 (44%) 16/50 (32%) 22/49 (45%) | 18/35 (51%) 24/50 (48%) 18/50 (36%) 31/49 (63%) |
|ADJUSTED (b) | 35.7% 57.9% 46.5% 52.0% | 57.9% 58.7% 41.6% 67.4% |
|TERMINAL (d) | 7/25 (28%) 12/28 (43%) 11/29 (38%) 15/35 (43%) | 16/29 (55%) 12/28 (43%) 13/38 (34%) 24/39 (62%) |
|FIRST INCIDENCE (DAYS) | 681 612 541 379 | 685 443 514 528 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.330 P=0.041 * P=0.250 P=0.126 | P=0.179 P=0.186 P=0.214N P=0.161 |
|INCIDENTAL TUMOR | P=0.178 P=0.203 P=0.387 P=0.159 | P=0.066 P=0.536N P=0.156N P=0.155 |
|LOGISTIC REGRESSION | P=0.199 P=0.064 P=0.278 P=0.105 | P=0.059 P=0.507N P=0.128N P=0.151 |
|COCHRAN-ARMITAGE | P=0.156 | P=0.056 |
|FISHER EXACT | P=0.111 P=0.463 P=0.098 | P=0.464N P=0.116N P=0.195 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 20/35 (57%) 32/50 (64%) 33/50 (66%) 46/49 (94%) | 24/35 (69%) 29/50 (58%) 25/50 (50%) 46/49 (94%) |
|ADJUSTED (b) | 71.4% 84.2% 89.2% 100.0% | 75.0% 69.8% 55.3% 97.9% |
|TERMINAL (d) | 17/25 (68%) 22/28 (79%) 25/29 (86%) 35/35 (100%)| 21/29 (72%) 16/28 (57%) 18/38 (47%) 38/39 (97%) |
|FIRST INCIDENCE (DAYS) | 681 612 541 379 | 685 443 514 528 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.005 ** P=0.058 P=0.038 * P=0.001 ** | P=0.009 ** P=0.238 P=0.184N P=0.006 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.290 P=0.049 * P<0.001 ** | P<0.001 ** P=0.359N P=0.090N P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.141 P=0.021 * P<0.001 ** | P<0.001 ** P=0.323N P=0.078N P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.339 P=0.273 P<0.001 ** | P=0.223N P=0.069N P=0.003 ** |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05074 TEST: 01 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DOWICIDE EC-7 PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
--multipart-boundary
Content-type: text/plain
Range: bytes 110402-110402/110402
--multipart-boundary--