TR 349 Mouse Pathology Tables
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
Facility: Battelle Columbus Laboratory
Chemical CAS #: 87-86-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 8| 2| 3| 2| 2| 2| 2| 3| 2| 4| 2| 2| 2| 2| 2| 3| 2| 3| 2| 2| 3| 9|
| 7| 2| 8| 5| 8| 0| 9| 9| 8| 9| 0| 8| 3| 8| 8| 7| 7| 8| 0| 8| 0| 8| 7| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + A + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + A + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 |
Infarct | 2 |
Hepatocyte, Necrosis, Acute, Focal | 2 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + M + + + + + + + + + + + +|
Acinus, Atrophy | 2 3 2 |
Duct, Cyst | |
Duct, Ectasia | 4 |
Duct, Hyperplasia | |
Duct, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Cyst | |
Capsule, Hyperplasia | 3 3 3 3 3 3 3 3 3 3 3 3 2 3 3 3 3 3 3 3 3 2 3 3 3|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 2 |
Hypertrophy | 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 8| 2| 3| 2| 2| 2| 2| 3| 2| 4| 2| 2| 2| 2| 2| 3| 2| 3| 2| 2| 3| 9|
| 7| 2| 8| 5| 8| 0| 9| 9| 8| 9| 0| 8| 3| 8| 8| 7| 7| 8| 0| 8| 0| 8| 7| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + A + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 2 3 3 3 2 3 4 3 3 3 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + A + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Follicle, Cyst | X X |
Follicular Cell, Hyperplasia | 4 2 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + A + + + + + + + + + + + +|
Angiectasis | 3 3 |
Inflammation, Chronic Active | 4 4 |
Follicle, Cyst | X X X X X X X |
Periovarian Tissue, Cyst | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + A + + + + + + + + + + + +|
Thrombosis | X X |
Endometrium, Hyperplasia, Cystic, | |
Glandular, Multifocal | 3 2 3 4 3 3 3 4 3 2 2 3 2 3 3 3 2 3 3 4 3 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | 2 2 2 2 4 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + A + + + + + + + + + + + +|
Mesenteric, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + A + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Pigmentation, Diffuse | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + M + + + + + + + + + + + +|
Necrosis | |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M M M + + + + + + + + M + +|
Degeneration, Acute | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia, Cystic | 2 2 3 2 2 2 3 2 2 2 2 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | X X X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 8| 2| 3| 2| 2| 2| 2| 3| 2| 4| 2| 2| 2| 2| 2| 3| 2| 3| 2| 2| 3| 9|
| 7| 2| 8| 5| 8| 0| 9| 9| 8| 9| 0| 8| 3| 8| 8| 7| 7| 8| 0| 8| 0| 8| 7| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Meninges, Infiltration Cellular, | |
Lymphocyte | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Metaplasia, | |
Focal | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + M + + + M + + + + + + M + M + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + A + + + + + + + + + + + +|
Nephropathy, Chronic | |
Renal Tubule, Regeneration | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 1| 2| 2| 3| 3| 2| 2| 2| 2| 2| | |
| 7| 8| 0| 0| 0| 7| 7| 8| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + M + | 32 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 34 |
Basophilic Focus | | 1 |
Clear Cell Focus | | 1 |
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 2 2 2 2 | 20 2.1|
Infarct | 2 | 2 2.0|
Hepatocyte, Necrosis, Acute, Focal | | 2 1.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 34 |
Acinus, Atrophy | 2 3 | 5 2.4|
Duct, Cyst | X | 1 |
Duct, Ectasia | 3 | 2 3.5|
Duct, Hyperplasia | 2 | 1 2.0|
Duct, Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 33 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 33 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 35 |
Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 35 |
Capsule, Cyst | X | 1 |
Capsule, Hyperplasia | 3 3 3 3 3 3 3 3 3 3 | 35 2.9|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 35 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 1| 2| 2| 3| 3| 2| 2| 2| 2| 2| | |
| 7| 8| 0| 0| 0| 7| 7| 8| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hypertrophy | 2 | 6 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 35 |
Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + I + + + + + | 32 |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 2 3 2 | 16 2.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 34 |
Inflammation, Chronic | | 1 2.0|
Follicle, Cyst | | 2 |
Follicular Cell, Hyperplasia | 2 2 | 5 2.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 34 |
Angiectasis | | 2 3.0|
Inflammation, Chronic Active | 4 | 3 4.0|
Follicle, Cyst | X X X X | 11 |
Periovarian Tissue, Cyst | | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 34 |
Thrombosis | | 2 |
Endometrium, Hyperplasia, Cystic, | | |
Glandular, Multifocal | 2 2 3 3 2 2 2 4 | 31 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 35 |
Femoral, Myelofibrosis | 4 2 | 13 2.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 34 |
Mesenteric, Hyperplasia, Lymphoid | 3 | 1 3.0|
Renal, Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 33 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
Pigmentation, Diffuse | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 34 |
Necrosis | 4 | 1 4.0|
Red Pulp, Hematopoietic Cell | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 1| 2| 2| 3| 3| 2| 2| 2| 2| 2| | |
| 7| 8| 0| 0| 0| 7| 7| 8| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Proliferation, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + | 30 |
Degeneration, Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + + + + | 33 |
Hyperplasia, Cystic | 2 3 3 3 2 2 | 19 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 35 |
Alopecia | X | 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 35 |
Compression | 3 | 1 3.0|
Meninges, Infiltration Cellular, | | |
Lymphocyte | 2 2 | 6 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 35 |
Alveolar Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 35 |
Olfactory Epithelium, Metaplasia, | | |
Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 34 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + M + + + + + + + | 29 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 34 |
Nephropathy, Chronic | 1 2 2 | 3 1.7|
Renal Tubule, Regeneration | 2 | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 34 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 6| 5| 7| 7| 4| 7| 4| 3| 7| 7| 7| 6|
DAY ON TEST | 5| 2| 2| 2| 0| 2| 3| 2| 2| 3| 2| 2| 6| 2| 9| 3| 2| 4| 2| 8| 2| 2| 2| 2| 4|
| 4| 8| 9| 8| 1| 7| 0| 7| 8| 0| 1| 7| 6| 9| 6| 0| 7| 3| 7| 3| 1| 7| 9| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
100 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + |
__________________________________________________________________________|
Gallbladder | A + + A + + + + |
__________________________________________________________________________|
Intestine Large | A + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | A + + A + + A + |
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | A + + + M + + + |
__________________________________________________________________________|
Intestine Small | A + + + + + A + |
__________________________________________________________________________|
Intestine Small, Duodenum | A A + + + + A + |
__________________________________________________________________________|
Intestine Small, Ileum | A + + A + + A + |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + A + + A + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X X |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2|
Infarct | 3 3 |
Inflammation, Chronic Active, Diffuse| 1 1 |
Pigmentation, Multifocal | 2 2 2 1 |
Hepatocyte, Cytomegaly, Diffuse | 2 1 1 1 1 1 2 1 1 2 1 2 2 1 1 1 1 1|
Hepatocyte, Cytomegaly, Focal | 2 |
Hepatocyte, Necrosis, Acute, Diffuse | 2 1 1 1 1 1 1 1 1 2 1 2 1 |
Hepatocyte, Necrosis, Acute, Focal | 2 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic Active | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + |
Hyperplasia, Lymphoid | 2 |
Acinus, Atrophy | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | M + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + A + + + + + |
Necrosis, Acute, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 3 3 3 2 3 2 3 3 3 2 3 3 3 3 2 2 2 3 2 3 3 3 3 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Cyst | X |
Hematopoietic Cell Proliferation | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 6| 5| 7| 7| 4| 7| 4| 3| 7| 7| 7| 6|
DAY ON TEST | 5| 2| 2| 2| 0| 2| 3| 2| 2| 3| 2| 2| 6| 2| 9| 3| 2| 4| 2| 8| 2| 2| 2| 2| 4|
| 4| 8| 9| 8| 1| 7| 0| 7| 8| 0| 1| 7| 6| 9| 6| 0| 7| 3| 7| 3| 1| 7| 9| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
100 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | M + + + + M + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 4 4 4 4|
Follicle, Cyst | X X X X |
Periovarian Tissue, Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + |
Angiectasis | |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | 4 |
Endometrium, Hyperplasia, Cystic, | |
Glandular, Multifocal | 3 2 3 3 3 3 4 2 3 3 3 4 2 3 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Lymphocytosis | X |
__________________________________________________________________________|
Bone Marrow | A + + + + + + + |
Femoral, Hyperplasia, Neutrophil | 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Inflammation, Acute | |
Mesenteric, Hematopoietic Cell | |
Proliferation | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 4 3 4 4|
__________________________________________________________________________|
Thymus | + + M M M M + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M + M M +|
Hyperplasia, Cystic | 2 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 6| 5| 7| 7| 4| 7| 4| 3| 7| 7| 7| 6|
DAY ON TEST | 5| 2| 2| 2| 0| 2| 3| 2| 2| 3| 2| 2| 6| 2| 9| 3| 2| 4| 2| 8| 2| 2| 2| 2| 4|
| 4| 8| 9| 8| 1| 7| 0| 7| 8| 0| 1| 7| 6| 9| 6| 0| 7| 3| 7| 3| 1| 7| 9| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
100 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + |
Alopecia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + |
__________________________________________________________________________|
Nose | + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + + + + M + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + |
Glomerulus, Amyloid Deposition, | |
Diffuse | 4 |
Renal Tubule, Dilatation | 3 |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + |
Dilatation | 4 |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 5| 5| 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 7| 4| 3| 3| 3| 2| 1| 6| 1| 4| 3| 1| 2| 3| 3| 2| 6| 2| 2| 2| 2| |
| 0| 0| 0| 7| 2| 2| 0| 1| 0| 8| 3| 9| 4| 5| 6| 2| 7| 0| 0| 7| 4| 9| 9| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
100 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 14 |
__________________________________________________________________________|____________|
Gallbladder | + A + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + | 14 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 13 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | | 2 |
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 2 2 2 2 2 2 2 2 2 3 2 3 2 2 3 2 3 3 2| 37 2.2|
Infarct | | 2 3.0|
Inflammation, Chronic Active, Diffuse| 2 2 | 4 1.5|
Pigmentation, Multifocal | | 4 1.8|
Hepatocyte, Cytomegaly, Diffuse | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1| 37 1.2|
Hepatocyte, Cytomegaly, Focal | | 1 2.0|
Hepatocyte, Necrosis, Acute, Diffuse | 1 1 1 1 1 1 1 2| 21 1.2|
Hepatocyte, Necrosis, Acute, Focal | 2 1 1 | 4 1.5|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Inflammation, Chronic Active | 3 | 3 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 16 |
Hyperplasia, Lymphoid | | 1 2.0|
Acinus, Atrophy | 4 | 1 4.0|
Duct, Cyst | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + M | 12 |
__________________________________________________________________________|____________|
Stomach | + + + + + + | 14 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 14 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 13 |
Necrosis, Acute, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Capsule, Hyperplasia | 3 3 3 2 2 3 3 3 2 2 2 3 2 3 3 2 2 2 2 3 2 2 3 3 2| 49 2.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 5| 5| 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 7| 4| 3| 3| 3| 2| 1| 6| 1| 4| 3| 1| 2| 3| 3| 2| 6| 2| 2| 2| 2| |
| 0| 0| 0| 7| 2| 2| 0| 1| 0| 8| 3| 9| 4| 5| 6| 2| 7| 0| 0| 7| 4| 9| 9| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
100 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Adrenal Cortical Nodule | X | 1 |
Cyst | | 1 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia | 2 | 1 2.0|
Hypertrophy | 3 1 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 16 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + | 11 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + | 17 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + | 24 |
Inflammation, Chronic Active | 4 4 4 | 8 4.0|
Follicle, Cyst | X X X | 7 |
Periovarian Tissue, Cyst | X | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + +| 36 |
Angiectasis | 2 | 1 2.0|
Inflammation, Acute | 3 3 2 | 4 2.5|
Inflammation, Chronic Active | | 1 4.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular, Multifocal | 3 2 2 2 2 2 3 3 3 2 2 3 3 4 3| 30 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
Lymphocytosis | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 13 |
Femoral, Hyperplasia, Neutrophil | 3 | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + | 23 |
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Inflammation, Acute | 3 | 1 3.0|
Mesenteric, Hematopoietic Cell | | |
Proliferation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M | 16 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 5| 5| 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 7| 4| 3| 3| 3| 2| 1| 6| 1| 4| 3| 1| 2| 3| 3| 2| 6| 2| 2| 2| 2| |
| 0| 0| 0| 7| 2| 2| 0| 1| 0| 8| 3| 9| 4| 5| 6| 2| 7| 0| 0| 7| 4| 9| 9| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
100 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + | 26 |
Hyperplasia, Lymphoid | | 1 4.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | 3 3 3 4 | 8 3.5|
__________________________________________________________________________|____________|
Thymus | M + M + + + + | 9 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M M + M | 6 |
Hyperplasia, Cystic | 2 | 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 22 |
Alopecia | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 14 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + | 15 |
__________________________________________________________________________|____________|
Nose | + + + + + + | 14 |
__________________________________________________________________________|____________|
Trachea | + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + M M + + | 12 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + | 15 |
Glomerulus, Amyloid Deposition, | | |
Diffuse | | 1 4.0|
Renal Tubule, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + M + + + | 12 |
Dilatation | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 2| 2| 3| 9| 2| 1| 2| 2| 2| 2| 3| 0| 3| 3| 2| 8| 3| 2| 2| 2| 2| 2|
| 0| 8| 8| 8| 7| 0| 9| 9| 1| 9| 8| 7| 7| 5| 6| 0| 0| 9| 9| 0| 7| 9| 9| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
200 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + |
__________________________________________________________________________|
Gallbladder | A |
__________________________________________________________________________|
Intestine Large | + |
__________________________________________________________________________|
Intestine Large, Cecum | + |
__________________________________________________________________________|
Intestine Large, Colon | + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + |
__________________________________________________________________________|
Intestine Small | + |
__________________________________________________________________________|
Intestine Small, Duodenum | + |
__________________________________________________________________________|
Intestine Small, Ileum | + |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | |
Clear Cell Focus, Multiple | X X X X |
Degeneration, Cystic | 3 |
Hematopoietic Cell Proliferation, | |
Multifocal | 1 2 2 2 2 2 3 2 3 3 2 2 2 2 2 2 2|
Inflammation, Chronic Active, Diffuse| 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 1 1 |
Inflammation, Chronic Active, Focal | |
Pigmentation, Multifocal | 2 1 1 2 2 1 2 2 2 2 2 2 2|
Bile Duct, Cyst | X |
Bile Duct, Cyst, Multiple | X |
Bile Duct, Hyperplasia, Multifocal | |
Hepatocyte, Cytomegaly, Diffuse | 2 2 2 1 2 2 2 1 2 2 2 2 3 2 2 3 2 2 2 2 2 2 2 2 2|
Hepatocyte, Necrosis, Acute, Diffuse | 2 1 2 1 2 1 2 1 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Mesentery | |
Inflammation, Acute | |
__________________________________________________________________________|
Pancreas | + |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | M |
__________________________________________________________________________|
Stomach | + |
__________________________________________________________________________|
Stomach, Forestomach | + |
__________________________________________________________________________|
Stomach, Glandular | + |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + A + + + + + + + + + + + + + + + + + +|
Capsule, Cyst | X|
Capsule, Hyperplasia | 3 3 3 3 3 2 3 3 2 3 3 3 3 3 3 2 3 3 3 3 3 3 3 3|
Corticomedullary Junction, Cyst | X X |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 2| 2| 3| 9| 2| 1| 2| 2| 2| 2| 3| 0| 3| 3| 2| 8| 3| 2| 2| 2| 2| 2|
| 0| 8| 8| 8| 7| 0| 9| 9| 1| 9| 8| 7| 7| 5| 6| 0| 0| 9| 9| 0| 7| 9| 9| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
200 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + A + + + + + + + + + + + + + + + + + +|
Hypertrophy, Focal | |
Hypertrophy | 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + A + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + |
__________________________________________________________________________|
Parathyroid Gland | M |
__________________________________________________________________________|
Pituitary Gland | + I + + + + |
Pars Distalis, Hyperplasia | 3 2 |
__________________________________________________________________________|
Thyroid Gland | + |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + +|
Hyperplasia, Tubular | |
Inflammation, Chronic Active | 4 4 4 |
Follicle, Cyst | X X X|
Periovarian Tissue, Cyst | X X X X|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 2 3 |
Endometrium, Hyperplasia, Cystic, | |
Glandular, Multifocal | 3 3 3 3 3 3 3 3 3 3 3 2 3 3 3 3 2 4 3 4|
Endometrium, Hyperplasia, Cystic, | |
Multifocal, Reticulum Cell | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + |
Femoral, Hyperplasia, Diffuse, | |
Neutrophil | |
Femoral, Hyperplasia, Neutrophil | 3 |
Femoral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + M + + +|
Mesenteric, Hematopoietic Cell | |
Proliferation | 3 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + |
__________________________________________________________________________|
Spleen | + + + + + + + + |
Hemorrhage | 4 |
Necrosis | 4 |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 3 3 3 |
__________________________________________________________________________|
Thymus | + + |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 2| 2| 3| 9| 2| 1| 2| 2| 2| 2| 3| 0| 3| 3| 2| 8| 3| 2| 2| 2| 2| 2|
| 0| 8| 8| 8| 7| 0| 9| 9| 1| 9| 8| 7| 7| 5| 6| 0| 0| 9| 9| 0| 7| 9| 9| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
200 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + |
__________________________________________________________________________|
Skin | + + + + + + +|
Alopecia | X X X X X|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + |
Joint, Tarsal, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + |
Interstitium, Inflammation, Chronic | |
Active | 3 |
Mediastinum, Inflammation, Acute | 4 |
__________________________________________________________________________|
Nose | + |
Glands, Inflammation, Acute, Focal | 2 |
Olfactory Epithelium, Metaplasia, | |
Focal | 2 |
__________________________________________________________________________|
Trachea | + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | M |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + |
__________________________________________________________________________|
Urinary Bladder | + |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 0| 3| 3| 3| 3| 2| 1| 2| 3| 2| 3| 2| 2| 2| 2| 2| 2| 4| 3| 2| 2| 2| 2| 1| |
| 9| 7| 0| 0| 0| 6| 7| 4| 7| 0| 7| 1| 7| 8| 8| 9| 9| 6| 8| 0| 9| 7| 7| 8| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
200 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + M + + | 4 |
__________________________________________________________________________|____________|
Gallbladder | + A + + | 3 |
__________________________________________________________________________|____________|
Intestine Large | + + + + A | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + A | 3 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A | 4 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A | 4 |
__________________________________________________________________________|____________|
Intestine Small | + A + + A | 4 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + A | 3 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + A | 3 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + A | 3 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Basophilic Focus | X | 1 |
Clear Cell Focus | X | 1 |
Clear Cell Focus, Multiple | X X X X X X X X | 12 |
Degeneration, Cystic | 2 2 2 2 3 | 6 2.3|
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 1 2 | 35 2.1|
Inflammation, Chronic Active, Diffuse| 1 2 2 2 2 2 1 1 1 1 1 3| 29 1.4|
Inflammation, Chronic Active, Focal | 3 | 1 3.0|
Pigmentation, Multifocal | 2 2 2 1 2 2 2 2 2 1 1 2 2 2 2 2 2 1 2 | 32 1.8|
Bile Duct, Cyst | | 1 |
Bile Duct, Cyst, Multiple | | 1 |
Bile Duct, Hyperplasia, Multifocal | 4 | 1 4.0|
Hepatocyte, Cytomegaly, Diffuse | 2 2 2 2 2 2 1 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 3| 49 2.0|
Hepatocyte, Necrosis, Acute, Diffuse | 2 2 2 2 2 1 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3| 49 1.9|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 7 |
Duct, Ectasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + M + + | 3 |
__________________________________________________________________________|____________|
Stomach | + + + + A | 5 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + A | 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A | 5 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 0| 3| 3| 3| 3| 2| 1| 2| 3| 2| 3| 2| 2| 2| 2| 2| 2| 4| 3| 2| 2| 2| 2| 1| |
| 9| 7| 0| 0| 0| 6| 7| 4| 7| 0| 7| 1| 7| 8| 8| 9| 9| 6| 8| 0| 9| 7| 7| 8| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
200 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + A + + + + + A| 47 |
Capsule, Cyst | | 1 |
Capsule, Hyperplasia | 2 2 3 3 3 3 2 2 3 3 3 3 3 2 3 3 3 2 2 2 3 3 2 | 47 2.7|
Corticomedullary Junction, Cyst | | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + A + + + + + A| 47 |
Hypertrophy, Focal | 2 | 1 2.0|
Hypertrophy | 3 2 | 5 2.2|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + A + + + + + A| 46 |
Hyperplasia | 2 2 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 5 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + | 3 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + A| 9 |
Pars Distalis, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + M + + | 4 |
Follicle, Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 17 |
Hyperplasia, Tubular | 3 | 1 3.0|
Inflammation, Chronic Active | 4 | 4 4.0|
Follicle, Cyst | X X X X X X X | 10 |
Periovarian Tissue, Cyst | X | 5 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 41 |
Inflammation, Acute | 3 | 4 2.8|
Endometrium, Hyperplasia, Cystic, | | |
Glandular, Multifocal | 3 3 3 2 2 4 2 3 3 4 2 3 3 3 4 3 3 | 37 3.0|
Endometrium, Hyperplasia, Cystic, | | |
Multifocal, Reticulum Cell | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 5 |
Femoral, Hyperplasia, Diffuse, | | |
Neutrophil | 3 | 1 3.0|
Femoral, Hyperplasia, Neutrophil | | 1 3.0|
Femoral, Myelofibrosis | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 0| 3| 3| 3| 3| 2| 1| 2| 3| 2| 3| 2| 2| 2| 2| 2| 2| 4| 3| 2| 2| 2| 2| 1| |
| 9| 7| 0| 0| 0| 6| 7| 4| 7| 0| 7| 1| 7| 8| 8| 9| 9| 6| 8| 0| 9| 7| 7| 8| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
200 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 11 |
Mesenteric, Hematopoietic Cell | | |
Proliferation | 2 2 | 4 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 4 |
__________________________________________________________________________|____________|
Spleen | + + + + A + + + + + | 17 |
Hemorrhage | | 1 4.0|
Necrosis | | 1 4.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | 3 3 | 5 3.0|
__________________________________________________________________________|____________|
Thymus | M + + + | 5 |
Inflammation, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + +| 7 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + | 18 |
Alopecia | X X | 7 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 5 |
Joint, Tarsal, Hyperostosis | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 6 |
Interstitium, Inflammation, Chronic | | |
Active | | 1 3.0|
Mediastinum, Inflammation, Acute | 2 | 2 3.0|
__________________________________________________________________________|____________|
Nose | + + + + | 5 |
Glands, Inflammation, Acute, Focal | 1 | 2 1.5|
Olfactory Epithelium, Metaplasia, | | |
Focal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + M + + | 4 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + M + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 0| 3| 3| 3| 3| 2| 1| 2| 3| 2| 3| 2| 2| 2| 2| 2| 2| 4| 3| 2| 2| 2| 2| 1| |
| 9| 7| 0| 0| 0| 6| 7| 4| 7| 0| 7| 1| 7| 8| 8| 9| 9| 6| 8| 0| 9| 7| 7| 8| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
200 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 8 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 0| 2| 2| 2| 2| 3| 3| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 7| 2| 8| 2| 2| 2|
| 2| 9| 9| 8| 7| 0| 0| 7| 7| 8| 7| 9| 8| 9| 9| 7| 9| 7| 8| 0| 9| 9| 9| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
600 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + + + + + + + + + + + + + + + + + A + A + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + A + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X X X X X X X X|
Clear Cell Focus, Multiple | X X X X X X X |
Cytomegaly, Diffuse | |
Degeneration, Cystic | |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 2 2 2 3 2 2 2 2 2 3 2 2 2 3 2 2 2 2 2 2 2 2 2|
Inflammation, Chronic Active, Diffuse| 2 2 2 2 1 2 2 2 1 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2|
Pigmentation, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Bile Duct, Cyst | |
Bile Duct, Hyperplasia, Multifocal | 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Hepatocyte, Cytomegaly, Diffuse | 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 3 2 3 3 3|
Hepatocyte, Necrosis, Acute, Diffuse | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 2 3 3 2 2 2 3 2 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 0| 2| 2| 2| 2| 3| 3| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 7| 2| 8| 2| 2| 2|
| 2| 9| 9| 8| 7| 0| 0| 7| 7| 8| 7| 9| 8| 9| 9| 7| 9| 7| 8| 0| 9| 9| 9| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
600 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + I + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 3 2 2 3 2 3 2 2 2 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Ultimobranchial Cyst | X |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 3 2 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X X X X X X |
Periovarian Tissue, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Endometrium, Hyperplasia, Cystic, | |
Glandular, Multifocal | 3 2 2 3 2 2 2 3 3 2 2 2 2 3 3 2 3 2 2 3 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | 2 2 2 3 2 2 2 2 2 3 3 2 2|
__________________________________________________________________________|
Lymph Node | M + + + + + + + + + + + + + + + + + + + + M + + +|
Lumbar, Hematopoietic Cell | |
Proliferation | |
Mesenteric, Hematopoietic Cell | |
Proliferation | 3 2 |
Mesenteric, Hematopoietic Cell | |
Proliferation, Multifocal | 2 3 2 |
Renal, Hematopoietic Cell | |
Proliferation | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + A + + + + +|
Depletion Lymphoid | 2 |
Hyperplasia, Lymphoid | 3 |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 2 4 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 0| 2| 2| 2| 2| 3| 3| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 7| 2| 8| 2| 2| 2|
| 2| 9| 9| 8| 7| 0| 0| 7| 7| 8| 7| 9| 8| 9| 9| 7| 9| 7| 8| 0| 9| 9| 9| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
600 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | M + M + + + + + + + + + + + + + + + + + M M + + +|
Hyperplasia, Cystic | 2 3 2 2 3 3 3 3 3 2 3 4 2 2 3 2 |
__________________________________________________________________________|
Skin | A + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | X |
Ulcer | 4 |
Sebaceous Gland, Hyperplasia | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | A + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Infiltration Cellular, | |
Lymphocyte | 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Inflammation, Acute, Focal | 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Olfactory Epithelium, Metaplasia, | |
Focal | 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Trachea | A + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | A + + + M M M M + + + + + + M M M M M M M + M + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 3 |
Nephropathy, Chronic | 2 |
Glomerulus, Inflammation, Chronic, | |
Diffuse | |
Renal Tubule, Regeneration | 2 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| |
DAY ON TEST | 2| 2| 3| 2| 2| 5| 1| 2| 2| 2| 1| 2| 5| 2| 2| 2| 3| 3| 3| 3| 1| 2| 2| 2| 8| |
| 9| 7| 0| 7| 8| 5| 6| 8| 8| 8| 1| 9| 3| 9| 8| 9| 0| 0| 0| 0| 2| 8| 8| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
600 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + A M + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + A A + + + A + A + + + + + + + + + + + | 42 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + A A + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A A + + + + + + + + + + + + + + + + + | 45 |
Peyer's Patch, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A A + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A A + + + M + + + + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A A + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A A + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A A + + + + + + + + + + + + + + + + + | 46 |
Peyer's Patch, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A A + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Liver | + + + + + A + + + + + + + + + + + + + + + + + + | 48 |
Clear Cell Focus | X X X X X | 13 |
Clear Cell Focus, Multiple | X X X X X X | 13 |
Cytomegaly, Diffuse | 3 | 1 3.0|
Degeneration, Cystic | 2 | 1 2.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 2 2 2 3 2 2 2 2 2 2 2 2 3 3 3 3 3 2 3 3 | 45 2.2|
Inflammation, Chronic Active, Diffuse| 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 47 1.9|
Pigmentation, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 48 2.0|
Bile Duct, Cyst | X X | 2 |
Bile Duct, Hyperplasia, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 40 2.0|
Hepatocyte, Cytomegaly, Diffuse | 3 3 3 3 3 3 3 3 3 3 3 3 2 3 3 3 2 2 3 3 3 3 | 47 2.5|
Hepatocyte, Necrosis, Acute, Diffuse | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 48 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + A A + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + M + M + + + + + + + + + + + + + + + + + | 46 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + A A + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + A A + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + A A + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + M + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| |
DAY ON TEST | 2| 2| 3| 2| 2| 5| 1| 2| 2| 2| 1| 2| 5| 2| 2| 2| 3| 3| 3| 3| 1| 2| 2| 2| 8| |
| 9| 7| 0| 7| 8| 5| 6| 8| 8| 8| 1| 9| 3| 9| 8| 9| 0| 0| 0| 0| 2| 8| 8| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
600 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Capsule, Hyperplasia | 2 3 2 3 3 3 3 3 3 3 3 3 2 3 3 3 3 3 2 3 3 3 2 3 | 49 2.9|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Degeneration, Fatty | 3 | 2 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia | 2 2 3 3 3 2 2 | 17 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + A A + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M M + + + + + + + M M + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + M + + M M + + + + + + + + + + + + + + + + + | 44 |
Pars Distalis, Hyperplasia | 3 3 3 3 2 3 | 19 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + A M + + + + + + + + M + + + + + + + + | 46 |
Inflammation, Chronic | 3 | 1 3.0|
Ultimobranchial Cyst | | 1 |
Follicle, Cyst | X | 2 |
Follicular Cell, Hyperplasia | 3 | 5 2.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + A + + + + + + + + + + + + + + + + + + | 48 |
Follicle, Cyst | X X X X X X | 12 |
Periovarian Tissue, Cyst | X X | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + A + + + + + + + + + + + + + + + + + + | 47 |
Inflammation, Chronic Active | | 1 2.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular, Multifocal | 3 3 2 2 2 2 3 3 3 2 2 2 3 3 2 2 2 3 | 40 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + A + + + + + + + + + + + + + + + + + + | 48 |
Femoral, Myelofibrosis | 2 2 3 2 2 2 3 | 20 2.3|
__________________________________________________________________________|____________|
Lymph Node | + M + + M A + + + + + + + + + + + + + + + + + + | 44 |
Lumbar, Hematopoietic Cell | | |
Proliferation | 3 | 1 3.0|
Mesenteric, Hematopoietic Cell | | |
Proliferation | 3 3 | 4 2.8|
Mesenteric, Hematopoietic Cell | | |
Proliferation, Multifocal | | 3 2.3|
Renal, Hematopoietic Cell | | |
Proliferation | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| |
DAY ON TEST | 2| 2| 3| 2| 2| 5| 1| 2| 2| 2| 1| 2| 5| 2| 2| 2| 3| 3| 3| 3| 1| 2| 2| 2| 8| |
| 9| 7| 0| 7| 8| 5| 6| 8| 8| 8| 1| 9| 3| 9| 8| 9| 0| 0| 0| 0| 2| 8| 8| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
600 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + M A M + + + + + + + + + + + + + + + + M | 42 |
Hyperplasia, Lymphoid | 3 | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + A + + + + + + + + + + + + + + + + + + | 47 |
Depletion Lymphoid | | 1 2.0|
Hyperplasia, Lymphoid | 3 | 2 3.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | 4 3 4 | 5 3.4|
__________________________________________________________________________|____________|
Thymus | + + + + + M M + M + M + + + + + + + + + + + + + | 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + M M + + + + + + + + M + + + + + M + + | 40 |
Hyperplasia, Cystic | 3 3 2 3 3 3 2 2 3 3 3 2 2 3 2 | 31 2.6|
__________________________________________________________________________|____________|
Skin | + + + + + A A + + + + + + + + + + + + + + + + + | 46 |
Alopecia | X | 2 |
Ulcer | | 1 4.0|
Sebaceous Gland, Hyperplasia | 3 | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Femur, Hyperostosis | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + M + + + + + + + + + + + + + + + + + | 47 |
Meninges, Infiltration Cellular, | | |
Lymphocyte | 2 2 | 5 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + M + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia, Lymphoid | 3 | 2 3.0|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + M + + + + + + + + + + + + + + + + + | 48 |
Glands, Inflammation, Acute, Focal | 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 46 2.0|
Olfactory Epithelium, Metaplasia, | | |
Focal | 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 45 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + A M + + + + + + + + + + + + + + + + + | 46 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| |
DAY ON TEST | 2| 2| 3| 2| 2| 5| 1| 2| 2| 2| 1| 2| 5| 2| 2| 2| 3| 3| 3| 3| 1| 2| 2| 2| 8| |
| 9| 7| 0| 7| 8| 5| 6| 8| 8| 8| 1| 9| 3| 9| 8| 9| 0| 0| 0| 0| 2| 8| 8| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
600 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + M M M + + M M + M + M + M + M M + M + + M M + | 23 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + A + + + + + + + + + + + + + + + + + + | 48 |
Infarct | | 1 3.0|
Nephropathy, Chronic | 2 4 | 3 2.7|
Glomerulus, Inflammation, Chronic, | | |
Diffuse | 3 | 1 3.0|
Renal Tubule, Regeneration | 2 | 5 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + + + + + + + + + M + + + + + + + + | 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 4| 1|
DAY ON TEST | 2| 2| 2| 3| 2| 5| 2| 9| 2| 2| 2| 3| 2| 2| 2| 2| 8| 3| 2| 2| 2| 2| 1| 7| 9|
| 8| 7| 9| 0| 7| 4| 9| 8| 9| 9| 9| 0| 7| 9| 9| 9| 1| 0| 9| 8| 7| 4| 0| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + A + + + + + + + + A + + + + + A A +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + A + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + A + + + + + A + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + A + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + M + + + + + + + + + + + + + + A + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + M + + + + + + + + A + + + + + A + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + A + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 |
Infarct | 4 2|
Inflammation, Acute | 2 |
Bile Duct, Hyperplasia, Multifocal | 4 |
Hepatocyte, Necrosis, Acute, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + A + + + + + + + +|
Inflammation, Acute | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + + + + + +|
Ulcer, Acute | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Ectopic Tissue | X X |
Capsule, Hyperplasia | 2 2 2 2 2 1 2 2 3 4 2 2 2 2 2 3 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 3 2 2 2 2 |
Hypertrophy | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + M + + + + M M M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + M + I + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 4| 1|
DAY ON TEST | 2| 2| 2| 3| 2| 5| 2| 9| 2| 2| 2| 3| 2| 2| 2| 2| 8| 3| 2| 2| 2| 2| 1| 7| 9|
| 8| 7| 9| 0| 7| 4| 9| 8| 9| 9| 9| 0| 7| 9| 9| 9| 1| 0| 9| 8| 7| 4| 0| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + + +|
Inflammation, Chronic Active | 3 3 3|
__________________________________________________________________________|
Preputial Gland | + + |
Inflammation, Chronic Active | |
Duct, Dilatation | 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Seminal Vesicle | + |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + |
Neutrophilia | X X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Neutrophil | 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + M + + + + + + + M + + M + + + + + + + +|
Lumbar, Hyperplasia, Lymphoid | 3|
Mesenteric, Hematopoietic Cell | |
Proliferation | 3 3 3 |
Mesenteric, Hematopoietic Cell | |
Proliferation, Multifocal | 3 |
Pancreatic, Inflammation, Chronic | |
Active | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + M + + M + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Depletion Lymphoid | 3 2 3 3|
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 3 3 3 2 3|
__________________________________________________________________________|
Thymus | + + + M + + + M + + + + M + I + M M M + M M M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 4| 1|
DAY ON TEST | 2| 2| 2| 3| 2| 5| 2| 9| 2| 2| 2| 3| 2| 2| 2| 2| 8| 3| 2| 2| 2| 2| 1| 7| 9|
| 8| 7| 9| 0| 7| 4| 9| 8| 9| 9| 9| 0| 7| 9| 9| 9| 1| 0| 9| 8| 7| 4| 0| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + I + +|
Acanthosis | 2 2 2|
Alopecia | X X X X |
Inflammation, Acute | 3 |
Metaplasia, Focal, Osseous | |
Necrosis | 4 |
Ulcer | 2|
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 3 |
Subcutaneous Tissue, Lymphatic, | |
Dilatation | 3 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Joint, Tarsal, Hyperostosis | X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Meninges, Infiltration Cellular, | |
Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Inflammation, Acute, Focal | 2 1 |
Olfactory Epithelium, Metaplasia, | |
Focal | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + M + + + + M + + + + M + + M M + + + + + + + + M|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 4 |
Infarct | 4 |
Inflammation, Chronic Active | 4 3 |
Nephropathy, Chronic | 2 |
Capsule, Fibrosis | 1 |
Renal Tubule, Dilatation | 2 3 3|
Renal Tubule, Regeneration | 2 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 4| 1|
DAY ON TEST | 2| 2| 2| 3| 2| 5| 2| 9| 2| 2| 2| 3| 2| 2| 2| 2| 8| 3| 2| 2| 2| 2| 1| 7| 9|
| 8| 7| 9| 0| 7| 4| 9| 8| 9| 9| 9| 0| 7| 9| 9| 9| 1| 0| 9| 8| 7| 4| 0| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urethra | + +|
Calculus Micro Observation Only | X|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + + + + A + +|
Calculus Micro Observation Only | |
Dilatation | 3 4 4 3|
Inflammation, Chronic Active | |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 0| 2| 2| 2| 2| 2| 2| 2| | |
| 0| 8| 5| 9| 8| 8| 8| 9| 9| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Gallbladder | + A + + + + + + + + | 30 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 32 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + + + + + + + | 31 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 33 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + M + + + + + + + + | 31 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + M + + + + + + + + | 30 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 32 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 35 |
Basophilic Focus | | 1 |
Hematopoietic Cell Proliferation, | | |
Multifocal | | 1 2.0|
Infarct | | 2 3.0|
Inflammation, Acute | | 1 2.0|
Bile Duct, Hyperplasia, Multifocal | | 1 4.0|
Hepatocyte, Necrosis, Acute, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + M + + + + + + + + | 34 |
Acinus, Atrophy | 1 | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Stomach | + M + + + + + + + + | 33 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + M + + + + + + + + | 33 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + M + + + + + + + + | 33 |
Ulcer, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 35 |
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + A + + + + + + + + | 34 |
Capsule, Ectopic Tissue | X | 3 |
Capsule, Hyperplasia | 3 3 2 2 2 2 2 3 2 | 30 2.2|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + A + + + + + + + + | 34 |
Cyst | X | 1 |
Hyperplasia | 2 | 6 2.2|
Hypertrophy | 1 2 | 4 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 0| 2| 2| 2| 2| 2| 2| 2| | |
| 0| 8| 5| 9| 8| 8| 8| 9| 9| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + A + + + + + + + + | 34 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + M + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + M + + + + | 28 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + M + + + | 29 |
Pars Distalis, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 35 |
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Penis | + + | 6 |
Inflammation, Chronic Active | | 3 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + | 3 |
Inflammation, Chronic Active | 4 | 1 4.0|
Duct, Dilatation | | 2 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 34 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 1 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 35 |
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 3 |
Neutrophilia | | 3 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 35 |
Femoral, Hyperplasia, Neutrophil | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + I + + + + + + + + | 31 |
Lumbar, Hyperplasia, Lymphoid | | 1 3.0|
Mesenteric, Hematopoietic Cell | | |
Proliferation | 2 3 | 5 2.8|
Mesenteric, Hematopoietic Cell | | |
Proliferation, Multifocal | | 1 3.0|
Pancreatic, Inflammation, Chronic | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 0| 2| 2| 2| 2| 2| 2| 2| | |
| 0| 8| 5| 9| 8| 8| 8| 9| 9| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Active | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + I + + + + + + + + | 31 |
__________________________________________________________________________|____________|
Spleen | + A + + + + + + + + | 34 |
Angiectasis | | 1 2.0|
Depletion Lymphoid | 3 | 5 2.8|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | | 5 2.8|
__________________________________________________________________________|____________|
Thymus | + M + + M + + + M + | 21 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 34 |
Acanthosis | | 3 2.0|
Alopecia | X | 5 |
Inflammation, Acute | | 1 3.0|
Metaplasia, Focal, Osseous | 2 | 1 2.0|
Necrosis | | 1 4.0|
Ulcer | 3 | 2 2.5|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | 3 | 2 3.0|
Subcutaneous Tissue, Lymphatic, | | |
Dilatation | 3 | 3 2.7|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 35 |
Joint, Tarsal, Hyperostosis | X X X X | 18 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 35 |
Cyst Epithelial Inclusion | X | 1 |
Meninges, Infiltration Cellular, | | |
Lymphocyte | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 35 |
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 35 |
Glands, Inflammation, Acute, Focal | 1 1 | 4 1.3|
Olfactory Epithelium, Metaplasia, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 0| 2| 2| 2| 2| 2| 2| 2| | |
| 0| 8| 5| 9| 8| 8| 8| 9| 9| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Focal | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 35 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + M M + + + + + + | 27 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 35 |
Hydronephrosis | | 1 4.0|
Infarct | | 1 4.0|
Inflammation, Chronic Active | 4 | 3 3.7|
Nephropathy, Chronic | | 1 2.0|
Capsule, Fibrosis | | 1 1.0|
Renal Tubule, Dilatation | | 3 2.7|
Renal Tubule, Regeneration | 2 | 12 2.0|
__________________________________________________________________________|____________|
Urethra | + | 3 |
Calculus Micro Observation Only | X | 2 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 33 |
Calculus Micro Observation Only | X | 1 |
Dilatation | 3 | 5 3.4|
Inflammation, Chronic Active | 2 | 1 2.0|
Mucosa, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
_____________________________________________________________________________________________________________________
| 6| 4| 2| 6| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7|
DAY ON TEST | 9| 7| 5| 1| 2| 5| 2| 2| 2| 2| 1| 3| 5| 0| 2| 2| 2| 5| 3| 2| 1| 6| 2| 2| 2|
| 5| 7| 4| 3| 7| 9| 9| 8| 8| 8| 1| 0| 5| 5| 9| 8| 8| 9| 0| 9| 3| 8| 7| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | A M + + + + |
__________________________________________________________________________|
Gallbladder | A A A + A + |
__________________________________________________________________________|
Intestine Large | A + + + A + |
__________________________________________________________________________|
Intestine Large, Cecum | A M M + A + |
__________________________________________________________________________|
Intestine Large, Colon | A + + + A + |
__________________________________________________________________________|
Intestine Large, Rectum | A M A + A M |
__________________________________________________________________________|
Intestine Small | A + + + A + |
__________________________________________________________________________|
Intestine Small, Duodenum | A A + + A |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + A |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + A |
__________________________________________________________________________|
Liver | + A + + + + + + + + + + + + + + + + + + A + + + +|
Basophilic Focus | |
Clear Cell Focus | X |
Clear Cell Focus, Multiple | X X X X X X X X|
Degeneration, Cystic | |
Hematopoietic Cell Proliferation, | |
Diffuse | |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2|
Hyperplasia, Focal | |
Infarct | |
Inflammation, Chronic Active, Diffuse| 2 2 1 2 2 2 1 1 2 1 2 1 2 2 2 2 2 2|
Pigmentation, Multifocal | 2 2 2 2 2 1 2 2 1 2 2 2 2 2 2 2 2 2 2 2|
Thrombosis, Multiple | X |
Bile Canaliculi, Hyperplasia, | |
Atypical, Diffuse | |
Bile Duct, Cyst | X |
Bile Duct, Cyst, Multiple | X |
Bile Duct, Hyperplasia, Multifocal | 2 |
Hepatocyte, Cytomegaly, Diffuse | 3 1 3 2 2 2 3 2 3 3 2 2 3 2 2 3 2 2 2 1 2 2 2|
Hepatocyte, Necrosis, Acute, Diffuse | 3 1 2 2 2 2 2 3 3 2 2 2 3 2 2 2 2 2 2 1 2 2 2|
__________________________________________________________________________|
Pancreas | A + + + A + |
Acinus, Atrophy | |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | A M + + + + |
__________________________________________________________________________|
Stomach | A + + + A + |
__________________________________________________________________________|
Stomach, Forestomach | A + + + A + |
Acanthosis | |
Hyperkeratosis | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | A + + + A + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
_____________________________________________________________________________________________________________________
| 6| 4| 2| 6| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7|
DAY ON TEST | 9| 7| 5| 1| 2| 5| 2| 2| 2| 2| 1| 3| 5| 0| 2| 2| 2| 5| 3| 2| 1| 6| 2| 2| 2|
| 5| 7| 4| 3| 7| 9| 9| 8| 8| 8| 1| 0| 5| 5| 9| 8| 8| 9| 0| 9| 3| 8| 7| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + A + + + + + + + + + + + + + + + + + + A + + + +|
Capsule, Hyperplasia | 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + A + + + + + + + + + + + + + + + + + + A + + + +|
Cytoplasmic Alteration | 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 2 2 |
Hypertrophy | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + A + + + + + + + + + + + + + + + + + + A + + + +|
Hyperplasia | 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | A + + + A + |
__________________________________________________________________________|
Parathyroid Gland | A M M + + + |
__________________________________________________________________________|
Pituitary Gland | M M + + M + |
__________________________________________________________________________|
Thyroid Gland | A M + + + + |
Follicular Cell, Hypertrophy | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + |
Spermatocele | X |
__________________________________________________________________________|
Penis | + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Preputial Gland | + + + |
Dilatation | 3 |
Hyperplasia | |
Inflammation, Chronic Active | 4 |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Prostate | A + + + A + |
Inflammation, Acute | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + |
Dilatation | 2 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Testes | + + + + A + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | A + + + A + |
Femoral, Hyperplasia, Diffuse, | |
Neutrophil | 3 |
Femoral, Hyperplasia, Neutrophil | 3 |
__________________________________________________________________________|
Lymph Node | A M M + + + + M |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
_____________________________________________________________________________________________________________________
| 6| 4| 2| 6| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7|
DAY ON TEST | 9| 7| 5| 1| 2| 5| 2| 2| 2| 2| 1| 3| 5| 0| 2| 2| 2| 5| 3| 2| 1| 6| 2| 2| 2|
| 5| 7| 4| 3| 7| 9| 9| 8| 8| 8| 1| 0| 5| 5| 9| 8| 8| 9| 0| 9| 3| 8| 7| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Angiectasis | 3 |
Hyperplasia, Plasma Cell | |
Mesenteric, Hematopoietic Cell | |
Proliferation | 3 |
Mesenteric, Hematopoietic Cell | |
Proliferation, Multifocal | |
__________________________________________________________________________|
Lymph Node, Mandibular | A M M + + M |
__________________________________________________________________________|
Spleen | A + + + + + A + +|
Cyst | X |
Depletion Lymphoid | 2 |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 4 4 4 2|
__________________________________________________________________________|
Thymus | M M M M A M |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M |
__________________________________________________________________________|
Skin | + A + + + + + + + + + + + + + + + + |
Acanthosis | |
Alopecia | X X X X X |
Cyst Epithelial Inclusion | |
Hyperkeratosis | 3 |
Ulcer | 4 3 2 4 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic | 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 3 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + |
Joint, Tarsal, Hyperostosis | X X X X X X X X X X X |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | A + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + |
Glands, Inflammation, Acute, Focal | 2 |
Nasolacrimal Duct, Inflammation, | |
Acute, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
_____________________________________________________________________________________________________________________
| 6| 4| 2| 6| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7|
DAY ON TEST | 9| 7| 5| 1| 2| 5| 2| 2| 2| 2| 1| 3| 5| 0| 2| 2| 2| 5| 3| 2| 1| 6| 2| 2| 2|
| 5| 7| 4| 3| 7| 9| 9| 8| 8| 8| 1| 0| 5| 5| 9| 8| 8| 9| 0| 9| 3| 8| 7| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Olfactory Epithelium, Metaplasia, | |
Focal | 1 |
__________________________________________________________________________|
Trachea | A M + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Hyperplasia, Focal | |
__________________________________________________________________________|
Harderian Gland | + M + + + A + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | A + + + + + + A + |
Hydronephrosis | |
Inflammation, Acute | 4 |
__________________________________________________________________________|
Urethra | + |
Calculus Micro Observation Only | X |
Inflammation, Acute | |
__________________________________________________________________________|
Urinary Bladder | A + + + A + |
Dilatation | |
Inflammation, Acute | 2 |
Mucosa, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 6| 3| 6| 7| 4| 7| 4| 5| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| |
DAY ON TEST | 1| 0| 9| 2| 3| 2| 4| 3| 1| 2| 2| 3| 2| 6| 3| 2| 2| 2| 2| 2| 9| 2| 2| 2| 8| |
| 2| 5| 0| 9| 1| 7| 0| 2| 2| 8| 3| 0| 7| 3| 0| 8| 7| 9| 7| 7| 7| 8| 8| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| A |
100 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + +| 11 |
__________________________________________________________________________|____________|
Gallbladder | + A A + A + A| 5 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + A +| 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A M + + A A| 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A +| 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + A +| 6 |
__________________________________________________________________________|____________|
Intestine Small | + A M + + A A| 7 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A M + + A A| 5 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A M + + A A| 6 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A M + + A A| 6 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Basophilic Focus | X X X | 3 |
Clear Cell Focus | X | 2 |
Clear Cell Focus, Multiple | X X X X X X X X X | 17 |
Degeneration, Cystic | 3 2 | 2 2.5|
Hematopoietic Cell Proliferation, | | |
Diffuse | 4 | 1 4.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 2 2 2 2 2 2 2 | 20 2.0|
Hyperplasia, Focal | 3 3 | 2 3.0|
Infarct | 4 | 1 4.0|
Inflammation, Chronic Active, Diffuse| 2 2 2 2 2 2 2 2 2 2 2 1 1 2 1 1 2 1 | 36 1.7|
Pigmentation, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 40 2.0|
Thrombosis, Multiple | | 1 |
Bile Canaliculi, Hyperplasia, | | |
Atypical, Diffuse | 4 | 1 4.0|
Bile Duct, Cyst | 2 | 2 2.0|
Bile Duct, Cyst, Multiple | X | 2 |
Bile Duct, Hyperplasia, Multifocal | 2 2 | 3 2.0|
Hepatocyte, Cytomegaly, Diffuse | 3 2 2 3 2 2 1 1 2 3 2 3 3 1 2 3 3 3 2 2 2 3 2 2 1| 48 2.2|
Hepatocyte, Necrosis, Acute, Diffuse | 2 1 1 3 2 2 1 1 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 | 47 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + +| 12 |
Acinus, Atrophy | 2 | 1 2.0|
Duct, Ectasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + +| 11 |
__________________________________________________________________________|____________|
Stomach | + + + + + + +| 11 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + +| 11 |
Acanthosis | 3 | 1 3.0|
Hyperkeratosis | 3| 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 6| 3| 6| 7| 4| 7| 4| 5| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| |
DAY ON TEST | 1| 0| 9| 2| 3| 2| 4| 3| 1| 2| 2| 3| 2| 6| 3| 2| 2| 2| 2| 2| 9| 2| 2| 2| 8| |
| 2| 5| 0| 9| 1| 7| 0| 2| 2| 8| 3| 0| 7| 3| 0| 8| 7| 9| 7| 7| 7| 8| 8| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| A |
100 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + +| 11 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + +| 13 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Capsule, Hyperplasia | 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 | 34 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cytoplasmic Alteration | | 1 2.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia | 2 2 2 2 | 7 2.0|
Hypertrophy | 3 | 3 2.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 2 2 3 2 2 2 2 2 2 | 19 2.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + +| 11 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + +| 10 |
__________________________________________________________________________|____________|
Pituitary Gland | + + M + + + +| 9 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + +| 11 |
Follicular Cell, Hypertrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + +| 13 |
Spermatocele | | 1 |
__________________________________________________________________________|____________|
Penis | + + | 6 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 8 |
Dilatation | | 1 3.0|
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic Active | 3 3 2 2 3 | 6 2.8|
Duct, Dilatation | 4 | 2 3.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + +| 11 |
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 6| 3| 6| 7| 4| 7| 4| 5| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| |
DAY ON TEST | 1| 0| 9| 2| 3| 2| 4| 3| 1| 2| 2| 3| 2| 6| 3| 2| 2| 2| 2| 2| 9| 2| 2| 2| 8| |
| 2| 5| 0| 9| 1| 7| 0| 2| 2| 8| 3| 0| 7| 3| 0| 8| 7| 9| 7| 7| 7| 8| 8| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| A |
100 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Dilatation | 3 | 2 2.5|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + +| 12 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + A| 10 |
Femoral, Hyperplasia, Diffuse, | | |
Neutrophil | | 1 3.0|
Femoral, Hyperplasia, Neutrophil | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + M + + + + + + + + +| 14 |
Angiectasis | | 1 3.0|
Hyperplasia, Plasma Cell | 2 | 1 2.0|
Mesenteric, Hematopoietic Cell | | |
Proliferation | 3 2 2 | 4 2.5|
Mesenteric, Hematopoietic Cell | | |
Proliferation, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + +| 8 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + +| 19 |
Cyst | | 1 |
Depletion Lymphoid | 2 3| 3 2.3|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | 2 4 3 4 | 8 3.4|
__________________________________________________________________________|____________|
Thymus | + + M + + + M| 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + +| 32 |
Acanthosis | 3 3 3 | 3 3.0|
Alopecia | X X X | 8 |
Cyst Epithelial Inclusion | X | 1 |
Hyperkeratosis | | 1 3.0|
Ulcer | | 5 3.2|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | 3 | 3 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + +| 36 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 6| 3| 6| 7| 4| 7| 4| 5| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| |
DAY ON TEST | 1| 0| 9| 2| 3| 2| 4| 3| 1| 2| 2| 3| 2| 6| 3| 2| 2| 2| 2| 2| 9| 2| 2| 2| 8| |
| 2| 5| 0| 9| 1| 7| 0| 2| 2| 8| 3| 0| 7| 3| 0| 8| 7| 9| 7| 7| 7| 8| 8| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| A |
100 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Joint, Tarsal, Hyperostosis | X X X X X X X X X X X X X X X | 26 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + +| 12 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + +| 15 |
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2| 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + +| 13 |
Glands, Inflammation, Acute, Focal | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Acute, Focal | | 1 2.0|
Olfactory Epithelium, Metaplasia, | | |
Focal | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + +| 11 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cornea, Hyperplasia, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + +| 12 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + +| 14 |
Hydronephrosis | 3 | 1 3.0|
Inflammation, Acute | 2 | 2 3.0|
__________________________________________________________________________|____________|
Urethra | + | 2 |
Calculus Micro Observation Only | | 1 |
Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + A +| 11 |
Dilatation | 3 3 3 | 3 3.0|
Inflammation, Acute | | 1 2.0|
Mucosa, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3| 7| 6| 1| 3| 7| 7| 5| 7| 2| 2| 7| 2| 2|
DAY ON TEST | 8| 1| 2| 3| 2| 3| 2| 2| 3| 3| 2| 5| 2| 6| 4| 1| 2| 3| 9| 2| 9| 9| 2| 9| 9|
| 1| 6| 9| 0| 7| 0| 9| 8| 0| 0| 4| 2| 7| 0| 0| 5| 7| 0| 8| 9| 3| 2| 7| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + A + + A +|
__________________________________________________________________________|
Gallbladder | + + A + + A A A A A|
__________________________________________________________________________|
Intestine Large | + + + + + A + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A M + A A + A A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + A A M A A|
__________________________________________________________________________|
Intestine Small | + + + M + A A + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + A M + A A + A +|
__________________________________________________________________________|
Intestine Small, Ileum | A + A M + A A + A A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + M + A A + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + A + + + + A +|
Clear Cell Focus, Multiple | X X X X X X X X X X |
Degeneration, Cystic | 3 |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 2 2 2 2 2 |
Hyperplasia, Focal | 3 |
Infarct | |
Inflammation, Chronic Active, Diffuse| 2 2 2 1 2 2 2 1 1 1 2 2 2 2 1 3 2 2 1 1 2 2|
Pigmentation, Multifocal | 3 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 |
Bile Duct, Cyst | 4 X |
Bile Duct, Cyst, Multifocal | |
Bile Duct, Hyperplasia, Multifocal | 2 2 2 |
Hepatocyte, Cytomegaly, Diffuse | 2 2 3 3 3 2 3 2 2 3 2 3 3 2 2 2 3 3 2 3 2 3 2|
Hepatocyte, Necrosis, Acute, Diffuse | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 1 2 2 2 2 2 3 2|
__________________________________________________________________________|
Pancreas | + + M + + A + + M +|
__________________________________________________________________________|
Salivary Glands | + + + + + A + + A +|
__________________________________________________________________________|
Stomach | + + + + + A A + A +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + A A + A +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + A A + A +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + +|
Degeneration, Chronic | 2 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + A +|
Capsule, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + A +|
Hyperplasia | |
Hypertrophy | 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + A +|
Hyperplasia | 2 2 1 2 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + M + + A + + M +|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3| 7| 6| 1| 3| 7| 7| 5| 7| 2| 2| 7| 2| 2|
DAY ON TEST | 8| 1| 2| 3| 2| 3| 2| 2| 3| 3| 2| 5| 2| 6| 4| 1| 2| 3| 9| 2| 9| 9| 2| 9| 9|
| 1| 6| 9| 0| 7| 0| 9| 8| 0| 0| 4| 2| 7| 0| 0| 5| 7| 0| 8| 9| 3| 2| 7| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + M + M M M M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + M I + M +|
__________________________________________________________________________|
Thyroid Gland | + + + + + M M + A +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | + + + |
Inflammation, Chronic Active | 2 4 3 |
__________________________________________________________________________|
Prostate | + + + + + M M + + +|
Inflammation, Acute | 2 2 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Neutrophilia | |
__________________________________________________________________________|
Bone Marrow | + + + + + A A A A +|
Femoral, Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node | + + + + + + + M + + + M|
Mesenteric, Hematopoietic Cell | |
Proliferation | 3 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + M|
Depletion Lymphoid | |
Necrosis | 2 |
__________________________________________________________________________|
Spleen | + + + + + + A A + A +|
Depletion Lymphoid | 3 2 2 2 3 2|
Necrosis | 3 |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | |
__________________________________________________________________________|
Thymus | + + + M + M M + A +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + I + + + + + A + + + + +|
Acanthosis | |
Alopecia | |
Inflammation, Chronic Active | 3 |
Ulcer, Focal | 3 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3| 7| 6| 1| 3| 7| 7| 5| 7| 2| 2| 7| 2| 2|
DAY ON TEST | 8| 1| 2| 3| 2| 3| 2| 2| 3| 3| 2| 5| 2| 6| 4| 1| 2| 3| 9| 2| 9| 9| 2| 9| 9|
| 1| 6| 9| 0| 7| 0| 9| 8| 0| 0| 4| 2| 7| 0| 0| 5| 7| 0| 8| 9| 3| 2| 7| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Ulcer | 2 |
Subcutaneous Tissue, Inflammation, | |
Acute | 4 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 3 |
Subcutaneous Tissue, Necrosis, Acute | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + +|
Joint, Tarsal, Hyperostosis | X X X X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + A + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + +|
__________________________________________________________________________|
Nose | + + + M + + + + + +|
Glands, Inflammation, Acute, Focal | 1 |
Olfactory Epithelium, Atrophy | 1 |
Olfactory Epithelium, Metaplasia, | |
Focal | |
__________________________________________________________________________|
Trachea | + + + + + A + + A +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + M + M + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + A + + + +|
Hydronephrosis | |
Inflammation, Acute | |
Inflammation, Chronic Active | |
Pelvis, Inflammation, Acute | 3 |
Renal Tubule, Dilatation, Diffuse | 3 |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Metaplasia, Osseous | 2 |
Renal Tubule, Mineralization | 2 |
__________________________________________________________________________|
Urethra | + + + +|
Calculus Micro Observation Only | X X|
Inflammation, Acute | 3 3 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + A A + A +|
Dilatation | 4 3 4 3 3|
Inflammation, Chronic Active | 3 |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 1| 6| 7| 5| 7| 7| 3| 7| 0| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 5| 2| 2| 2| 3| 9| 2| 4| 2| 2| 4| 2| 2| 2| 2| 3| 2| 0| 0| 2| 3| 2| 7| 2| 3| |
| 1| 9| 9| 9| 4| 0| 9| 1| 7| 8| 2| 7| 6| 9| 8| 0| 7| 8| 3| 7| 0| 8| 8| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| A |
200 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + M + + + + | 15 |
__________________________________________________________________________|____________|
Gallbladder | + + + A + A A + | 9 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + + M M + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + M M M + + | 8 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + M + + | 13 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + M + + | 11 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + M M + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + M M + + | 12 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Clear Cell Focus, Multiple | X X X X X X X X X X X| 21 |
Degeneration, Cystic | | 1 3.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 2 2 2 2 3 2 2 2 2| 16 2.1|
Hyperplasia, Focal | 3 3 | 3 3.0|
Infarct | 4 | 1 4.0|
Inflammation, Chronic Active, Diffuse| 2 2 1 2 1 2 2 2 2 2 2 1 2 2 2 3 1 1 1 2 1 2| 44 1.7|
Pigmentation, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 37 2.0|
Bile Duct, Cyst | X | 3 4.0|
Bile Duct, Cyst, Multifocal | X X | 2 |
Bile Duct, Hyperplasia, Multifocal | 2 2 | 5 2.0|
Hepatocyte, Cytomegaly, Diffuse | 3 3 3 2 2 2 2 3 3 3 2 2 1 3 2 3 3 3 3 3 2 2 3 2 2| 48 2.5|
Hepatocyte, Necrosis, Acute, Diffuse | 3 2 2 2 1 1 2 2 2 3 3 2 2 2 2 2 3 3 2 2 2 2 2 2| 47 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + M + + + + | 14 |
__________________________________________________________________________|____________|
Salivary Glands | + + + M + + + + | 15 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + M + + + + | 17 |
Degeneration, Chronic | | 1 2.0|
Atrium, Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Capsule, Hyperplasia | 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2| 34 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 1| 6| 7| 5| 7| 7| 3| 7| 0| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 5| 2| 2| 2| 3| 9| 2| 4| 2| 2| 4| 2| 2| 2| 2| 3| 2| 0| 0| 2| 3| 2| 7| 2| 3| |
| 1| 9| 9| 9| 4| 0| 9| 1| 7| 8| 2| 7| 6| 9| 8| 0| 7| 8| 3| 7| 0| 8| 8| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| A |
200 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 2 | 1 2.0|
Hypertrophy | 2 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 2 2 2 2 2 | 13 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + M + + + + | 14 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M M + + + + | 11 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + | 14 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + M + + + + | 14 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Penis | + | 1 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + | 4 |
Inflammation, Chronic Active | 3 | 4 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + M + + | 15 |
Inflammation, Acute | | 3 2.3|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 2 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + | 18 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
Neutrophilia | X | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 14 |
Femoral, Hyperplasia, Neutrophil | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + M + + + + M M + + + + + + | 22 |
Mesenteric, Hematopoietic Cell | | |
Proliferation | 2 3 3 3 2 3 3 3 | 10 2.8|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + M M + + + | 13 |
Depletion Lymphoid | 3 | 1 3.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + M + + + + + +| 20 |
Depletion Lymphoid | | 6 2.3|
Necrosis | | 1 3.0|
Red Pulp, Hematopoietic Cell | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 1| 6| 7| 5| 7| 7| 3| 7| 0| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 5| 2| 2| 2| 3| 9| 2| 4| 2| 2| 4| 2| 2| 2| 2| 3| 2| 0| 0| 2| 3| 2| 7| 2| 3| |
| 1| 9| 9| 9| 4| 0| 9| 1| 7| 8| 2| 7| 6| 9| 8| 0| 7| 8| 3| 7| 0| 8| 8| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| A |
200 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Proliferation, Diffuse | 4 4 2 3 4 3 4| 7 3.4|
__________________________________________________________________________|____________|
Thymus | M + + M + + M + | 11 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + +| 26 |
Acanthosis | 2 | 1 2.0|
Alopecia | X X | 2 |
Inflammation, Chronic Active | | 1 3.0|
Ulcer, Focal | | 1 3.0|
Ulcer | 3 4 4| 4 3.3|
Subcutaneous Tissue, Inflammation, | | |
Acute | 4 | 2 4.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | 2 3 4 3| 5 3.0|
Subcutaneous Tissue, Necrosis, Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + +| 29 |
Joint, Tarsal, Hyperostosis | X X X X X X X X X| 14 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + M + + + + | 16 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + M + + + + | 19 |
__________________________________________________________________________|____________|
Nose | + + + + M + + + | 16 |
Glands, Inflammation, Acute, Focal | 2 2 | 3 1.7|
Olfactory Epithelium, Atrophy | | 1 1.0|
Olfactory Epithelium, Metaplasia, | | |
Focal | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + M + + + + | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + M M + M + | 13 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + +| 20 |
Hydronephrosis | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 1| 6| 7| 5| 7| 7| 3| 7| 0| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 5| 2| 2| 2| 3| 9| 2| 4| 2| 2| 4| 2| 2| 2| 2| 3| 2| 0| 0| 2| 3| 2| 7| 2| 3| |
| 1| 9| 9| 9| 4| 0| 9| 1| 7| 8| 2| 7| 6| 9| 8| 0| 7| 8| 3| 7| 0| 8| 8| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| A |
200 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic Active | 3 4| 2 3.5|
Pelvis, Inflammation, Acute | | 1 3.0|
Renal Tubule, Dilatation, Diffuse | | 1 3.0|
Renal Tubule, Dilatation | 2 | 2 2.0|
Renal Tubule, Metaplasia, Osseous | | 1 2.0|
Renal Tubule, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Urethra | | 4 |
Calculus Micro Observation Only | | 2 |
Inflammation, Acute | | 3 3.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + A + + | 15 |
Dilatation | 4 3 4 | 8 3.5|
Inflammation, Chronic Active | | 1 3.0|
Mucosa, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 3| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 0| 0| 2| 3| 2| 6| 2| 2| 3| 5| 3| 2| 2| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 3| 0|
| 8| 4| 7| 0| 9| 5| 7| 9| 0| 7| 0| 9| 8| 5| 0| 0| 8| 8| 8| 8| 8| 8| 8| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
600 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + M + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
Prolapse | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + M + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X |
Clear Cell Focus, Multiple | X X X X X X X X|
Hematopoietic Cell Proliferation, | |
Multifocal | 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 |
Infarct | 4|
Inflammation, Chronic Active, Diffuse| 2 2 2 2 1 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 |
Pigmentation, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Bile Duct, Cyst | X |
Bile Duct, Hyperplasia, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Hepatocyte, Cytomegaly, Diffuse | 3 3 3 3 3 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
Hepatocyte, Necrosis, Acute, Diffuse | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Degeneration | |
Acinus, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 2 2 |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | X |
Peridontal Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 3| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 0| 0| 2| 3| 2| 6| 2| 2| 3| 5| 3| 2| 2| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 3| 0|
| 8| 4| 7| 0| 9| 5| 7| 9| 0| 7| 0| 9| 8| 5| 0| 0| 8| 8| 8| 8| 8| 8| 8| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
600 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + M M M + + + M + M + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + M + M M M M + M + + + + + M|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2|
__________________________________________________________________________|
Penis | + |
Inflammation, Acute | |
__________________________________________________________________________|
Preputial Gland | + + |
Inflammation, Chronic Active | 3 3 |
Duct, Dilatation | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric, Hematopoietic Cell | |
Proliferation | 3 2 2 |
Mesenteric, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 4 4|
__________________________________________________________________________|
Thymus | + + M M + M M + M M + + M + + + M + + M M M + M|
Necrosis, Acute | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 3| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 0| 0| 2| 3| 2| 6| 2| 2| 3| 5| 3| 2| 2| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 3| 0|
| 8| 4| 7| 0| 9| 5| 7| 9| 0| 7| 0| 9| 8| 5| 0| 0| 8| 8| 8| 8| 8| 8| 8| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
600 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 3 3 |
Alopecia | X X X X X X X X X |
Ulcer | 4 |
Subcutaneous Tissue, Fibrosis | 2 |
Subcutaneous Tissue, Inflammation, | |
Acute | 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 3 |
Subcutaneous Tissue, Mineralization | |
Subcutaneous Tissue, Lymphatic, | |
Dilatation | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Joint, Tarsal, Hyperostosis | X X X X X X X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | |
Alveolar Epithelium, Bronchiole, | |
Hyperplasia | 2 |
Peribronchiolar, Glands, | |
Inflammation, Acute | |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Inflammation, Acute, Focal | 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1|
Nasolacrimal Duct, Inflammation, | |
Acute, Focal | |
Olfactory Epithelium, Metaplasia, | |
Focal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 2 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + M M M + M + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 3| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 0| 0| 2| 3| 2| 6| 2| 2| 3| 5| 3| 2| 2| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 3| 0|
| 8| 4| 7| 0| 9| 5| 7| 9| 0| 7| 0| 9| 8| 5| 0| 0| 8| 8| 8| 8| 8| 8| 8| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
600 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
Nephropathy, Chronic | 2 |
Renal Tubule, Dilatation | |
Renal Tubule, Regeneration | 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 4 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 2| 7| 7| 6| 4| 7| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 9| 2| 1| 5| 2| 2| 1| 5| 2| 2| 8| 3| 2| 3| 2| 3| 7| 2| 2| 3| 2| 2| 3| 1| |
| 6| 5| 9| 1| 3| 9| 8| 1| 8| 9| 7| 0| 0| 8| 0| 8| 0| 9| 7| 8| 0| 7| 9| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| A |
600 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + A + + + + + + + + A + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + M + + + + + + + + M + + + + + + +| 47 |
Prolapse | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + M + + + M + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + M + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + M + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | X X | 2 |
Clear Cell Focus | X X X | 4 |
Clear Cell Focus, Multiple | X X X X X X X | 15 |
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 40 2.1|
Infarct | 3| 2 3.5|
Inflammation, Chronic Active, Diffuse| 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 43 2.0|
Pigmentation, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 45 2.0|
Bile Duct, Cyst | | 1 |
Bile Duct, Hyperplasia, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2| 32 2.0|
Hepatocyte, Cytomegaly, Diffuse | 3 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 47 3.0|
Hepatocyte, Necrosis, Acute, Diffuse | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 46 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Degeneration | 3 | 1 3.0|
Acinus, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 3 3 | 2 3.0|
Inflammation, Chronic Active | 3 | 1 3.0|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Dysplasia | 2 | 3 2.0|
__________________________________________________________________________|____________|
Tooth | + + | 3 |
Developmental Malformation | | 1 |
Peridontal Tissue, Inflammation, | | |
Chronic Active | 4 3 | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 2| 7| 7| 6| 4| 7| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 9| 2| 1| 5| 2| 2| 1| 5| 2| 2| 8| 3| 2| 3| 2| 3| 7| 2| 2| 3| 2| 2| 3| 1| |
| 6| 5| 9| 1| 3| 9| 8| 1| 8| 9| 7| 0| 0| 8| 0| 8| 0| 9| 7| 8| 0| 7| 9| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| A |
600 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrium, Thrombosis | X| 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Capsule, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 29 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 2.0|
Hypertrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 41 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + + + + + + + I + M + + + + + + +| 38 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Follicular Cell, Hyperplasia | | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Granuloma Sperm | | 1 2.0|
__________________________________________________________________________|____________|
Penis | + + + | 4 |
Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + | 4 |
Inflammation, Chronic Active | 3 2 | 4 2.8|
Duct, Dilatation | 3 | 2 3.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Seminal Vesicle | + | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Germinal Epithelium, Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + M + + + + + + + + + + + + + + + M + + + + + + +| 47 |
Mesenteric, Hematopoietic Cell | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 2| 7| 7| 6| 4| 7| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 9| 2| 1| 5| 2| 2| 1| 5| 2| 2| 8| 3| 2| 3| 2| 3| 7| 2| 2| 3| 2| 2| 3| 1| |
| 6| 5| 9| 1| 3| 9| 8| 1| 8| 9| 7| 0| 0| 8| 0| 8| 0| 9| 7| 8| 0| 7| 9| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| A |
600 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Proliferation | 3 3 3 3 3 3 3| 10 2.8|
Mesenteric, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + M + + + + + + +| 47 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Depletion Lymphoid | 2 3 | 2 2.5|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | 4 3 4 4 4| 7 3.9|
__________________________________________________________________________|____________|
Thymus | M M + + + + + + + M M M + + + M M M M + + + + + M| 27 |
Necrosis, Acute | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 3 3 3 3 3 3 | 10 2.8|
Alopecia | X X X | 12 |
Ulcer | 3 3 2 2 | 5 2.8|
Subcutaneous Tissue, Fibrosis | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Acute | 4 | 2 3.5|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | 2 | 2 2.5|
Subcutaneous Tissue, Mineralization | 2 | 1 2.0|
Subcutaneous Tissue, Lymphatic, | | |
Dilatation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Joint, Tarsal, Hyperostosis | X X X X | 12 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Alveolar Epithelium, Hyperplasia | 2 2| 2 2.0|
Alveolar Epithelium, Bronchiole, | | |
Hyperplasia | | 1 2.0|
Peribronchiolar, Glands, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05074-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL, DOWICIDE EC7 Date: 05/05/97
Route: DOSED FEED Time: 14:47:10
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 2| 7| 7| 6| 4| 7| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 9| 2| 1| 5| 2| 2| 1| 5| 2| 2| 8| 3| 2| 3| 2| 3| 7| 2| 2| 3| 2| 2| 3| 1| |
| 6| 5| 9| 1| 3| 9| 8| 1| 8| 9| 7| 0| 0| 8| 0| 8| 0| 9| 7| 8| 0| 7| 9| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| A |
600 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Acute | 3 | 1 3.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | 2 | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Glands, Inflammation, Acute, Focal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2| 47 1.9|
Nasolacrimal Duct, Inflammation, | | |
Acute, Focal | 2 2 | 2 2.0|
Olfactory Epithelium, Metaplasia, | | |
Focal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 46 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Lens, Cataract | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + M M M + + + M M + + + M + M M + + + + + + M| 35 |
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 4 |
Nephropathy, Chronic | | 1 2.0|
Renal Tubule, Dilatation | 2 | 1 2.0|
Renal Tubule, Regeneration | 2 2 2 2 2 2 2 | 17 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Dilatation | 3 | 3 3.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
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