TR 349 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/09/94
EXP: 05074 DOWICIDE EC-7 PENTACHLOROPHENOL TIME: 06:58:06
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 55389
CONT: N01-ES-38068 CAS: 87-86-5
PATHOLOGIST: R. PERSING S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/09/94
EXP: 05074 DOWICIDE EC-7 PENTACHLOROPHENOL TIME: 06:58:06
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 55389
CONT: N01-ES-38068 CAS: 87-86-5
PATHOLOGIST: R. PERSING S. EUSTIS
DOWICIDE EC-7 PENTACHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 727 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 35 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 199 224 454 468 471 498 528 681 705 710 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 63 254 305 431 440 477 489 513 532 568 |
| 611 612 612 613 655 659 659 690 695 697 |
| 705 723 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 200 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 26 134 140 292 292 293 293 315 324 342 |
| 352 416 541 551 578 598 603 608 660 681 |
| 690 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DOWICIDE EC-7 PENTACHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 727 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 600 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 57 253 365 379 458 536 604 608 608 611 |
| 635 680 695 711 717 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DOWICIDE EC-7 PENTACHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 727 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 727 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 94.3 94.3 94.3 85.7 80.0 80.0 80.0 71.4 |
| | |
| | |
|100 PPM | 98.0 98.0 96.0 94.0 94.0 88.0 82.0 80.0 66.0 56.0 |
| | |
| | |
|200 PPM | 98.0 94.0 94.0 78.0 76.0 76.0 74.0 66.0 62.0 58.0 |
| | |
| | |
|600 PPM | 98.0 98.0 96.0 94.0 92.0 90.0 88.0 86.0 78.0 70.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 100 PPM 200 PPM 600 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 71.4% 56.0% 58.0% 70.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.496N P=0.255 P=0.241 P=1.000 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 493.8 545.6 415.7 527.8 |
|NATURAL DEATHS (C) | (56.8) (35.7) (42.7) (49.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 660.4 647.2 596.2 667.2 |
|(STANDARD ERROR) | (23.9) (20.1) (28.2) (19.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DOWICIDE EC-7 PENTACHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 727 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 35 UNCENSORED DEATHS 6 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 494 643 685 717 720 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 1 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 321 443 454 483 497 521 542 566 572 596 |
| 629 631 636 643 645 669 701 712 713 714 |
| 720 |
| CENSORED DEATHS |
| 564 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 200 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 514 626 631 635 636 648 689 699 706 707 |
| 710 711 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DOWICIDE EC-7 PENTACHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 727 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 600 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 485 502 516 528 555 611 653 668 670 689 |
| 712 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DOWICIDE EC-7 PENTACHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 727 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 727 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 97.1 97.1 94.3 82.9 |
| | |
| | |
|100 PPM | 100.0 100.0 100.0 98.0 98.0 92.0 86.0 79.9 69.6 57.3 |
| | |
| | |
|200 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 98.0 88.0 76.0 |
| | |
| | |
|600 PPM | 100.0 100.0 100.0 100.0 100.0 98.0 92.0 90.0 86.0 78.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 100 PPM 200 PPM 600 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 82.9% 57.3% 76.0% 78.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.567N P=0.016 P=0.558 P=0.687 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 663.5 590.9 659.3 599.0 |
|NATURAL DEATHS (C) | (36.1) (23.5) (16.6) (25.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 716.1 666.6 710.8 698.8 |
|(STANDARD ERROR) | ( 7.0) (13.8) ( 5.6) ( 9.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DOWICIDE EC-7 PENTACHLOROPHENOL
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
100 PPM = 2
200 PPM = 3
600 PPM = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
104 +
|
| 1 3 2 1
| 3 2 3 1 1 2
P 96 + 2 2 4
E | 3 1 3 2 4 4 2 1
R | 4 22 141
C | 2 4 2 4
E 88 + 1122 4 4
N | 3 3 1 2 1 2
T | 3 3 2 2
| 3 3 1 1 2 44
S 80 + 3 3 1 2 2 4 1
U | 3 3 4 1 1
R | 3 3 4 4
V | 33 411
I 72 + 3 3 2 2 141
V | 3 3 2 2 44
A | 33
L | 2 2
64 + 3 3 22
| 3 3
| 3322
| 3 2 2
56 + 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 13 obs hidden.
DOWICIDE EC-7 PENTACHLOROPHENOL
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
100 PPM = 2
200 PPM = 3
600 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 41 3
|
| 2 2 414 3 3 1
| 2 2 4 4 33
95 +
| 2 2 4 4 1 1
| 2 2 4 4
| 1 1
90 + 2 2 4 4 3 3
|
P | 2 2 4 34 3
E | 2 2 4 4 33 11
R 85 +
C | 22 33
E | 2 2 4 4 1
N |
T 80 + 2 2 4 33
|
S | 22 4 4
U | 3 3
R 75 +
V | 22
I |
V | 22
A 70 + 2 2
L |
| 2 2
|
65 + 22
|
|
|
60 + 22
|
| 22
|
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 4 obs hidden.
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