TR 351 Mouse Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
PARA-CHLOROANILINE
NTP Experiment-Test: 05020-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/03/94
Route: GAVAGE Time: 19:58:17
Facility: Battelle Columbus Laboratory
Chemical CAS #: 106-47-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05020-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 19:58:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund 5 4 3 4
Dead 5 1 3 5
Dosing Accident 1 3
Survivors
Terminal Sacrifice 39 42 44 41
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (47) (3) (2) (46)
Infiltration Cellular, Multifocal, Lymphocyte 1 (2%)
Lumen, Pigmentation, Diffuse 1 (2%)
Mucosa, Cyst 1 (2%)
Intestine Large, Colon (47) (5) (3) (48)
Parasite Metazoan 3 (6%)
Intestine Small, Duodenum (46) (4) (3) (48)
Inflammation, Chronic, Focal 1 (2%)
Ulcer, Chronic, Focal 1 (2%)
Intestine Small, Jejunum (46) (4) (2) (48)
Necrosis, Acute, Diffuse 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis, Focal 1 (2%)
Basophilic Focus 1 (2%) 1 (2%)
Clear Cell Focus 1 (2%) 2 (4%)
Cytomegaly, Focal 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation, Multifocal 15 (30%) 29 (58%) 24 (48%) 31 (62%)
Necrosis, Acute, Multifocal 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Thrombosis, Chronic 1 (2%)
Vacuolization Cytoplasmic, Focal 1 (2%) 1 (2%)
Bile Duct, Cyst 1 (2%)
Centrilobular, Necrosis, Acute, Multifocal 1 (2%)
Hepatocyte, Karyomegaly, Focal 1 (2%) 1 (2%)
Kupffer Cell, Pigmentation, Hemosiderin 1 (2%) 46 (92%)
Periportal, Inflammation, Multifocal 1 (2%)
Serosa, Inflammation, Chronic, Multifocal,
Suppurative 1 (2%)
Sinusoid, Infiltration Cellular, Diffuse,
Polymorphonuclear 1 (2%)
Mesentery (2) (2) (3) (3)
Inflammation, Chronic, Multifocal,
Suppurative 2 (67%)
Inflammation, Chronic Active, Multifocal 2 (100%) 2 (67%) 1 (33%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05020-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 19:58:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pancreas (48) (7) (5) (49)
Inflammation, Chronic, Multifocal,
Suppurative 1 (2%)
Inflammation, Chronic Active, Multifocal 1 (14%) 1 (20%)
Acinus, Atrophy, Diffuse 1 (2%)
Acinus, Atrophy, Focal 1 (2%) 2 (4%)
Acinus, Atrophy, Multifocal 1 (2%) 1 (14%) 2 (40%) 5 (10%)
Duct, Cyst 1 (14%) 1 (2%)
Duct, Cyst, Multiple 1 (2%)
Duct, Ectasia, Focal 1 (2%)
Duct, Ectasia, Multifocal 1 (20%)
Duct, Inflammation, Chronic, Multifocal 1 (2%)
Salivary Glands (47) (5) (3) (48)
Infiltration Cellular, Multifocal, Lymphocyte 3 (6%)
Acinus, Atrophy, Focal 1 (2%)
Stomach, Forestomach (48) (5) (3) (46)
Acanthosis, Focal 1 (2%)
Hyperkeratosis, Focal 1 (2%)
Ulcer, Acute, Focal 1 (2%)
Stomach, Glandular (48) (5) (3) (47)
Cyst 1 (2%)
Necrosis, Acute, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (5) (3) (50)
Atrium, Inflammation, Chronic, Focal 1 (33%)
Coronary Artery, Inflammation, Chronic
Active, Multifocal 1 (2%)
Epicardium, Inflammation, Acute, Multifocal 1 (20%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (5) (4) (49)
Capsule, Cyst 1 (2%)
Capsule, Hyperplasia, Cystic, Glandular,
Multifocal 1 (2%)
Capsule, Hyperplasia, Focal 1 (2%)
Capsule, Hyperplasia, Multifocal 48 (96%) 2 (40%) 3 (75%) 48 (98%)
Corticomedullary Junction, Degeneration,
Fatty, Multifocal 1 (2%)
Adrenal Gland, Cortex (50) (5) (4) (49)
Accessory Adrenal Cortical Nodule 1 (2%)
Degeneration, Fatty, Focal 1 (2%)
Hematopoietic Cell Proliferation, Multifocal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05020-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 19:58:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia, Focal 1 (2%) 1 (2%)
Hyperplasia, Multifocal 1 (2%)
Hypertrophy, Focal 2 (4%) 2 (4%)
Hypertrophy, Multifocal 1 (2%) 1 (2%)
Adrenal Gland, Medulla (50) (5) (4) (49)
Hyperplasia, Focal 1 (2%)
Infiltration Cellular, Focal, Plasma Cell 1 (2%)
Pituitary Gland (46) (5) (6) (42)
Pars Distalis, Cyst 3 (7%) 1 (2%)
Pars Distalis, Cyst, Multiple 1 (2%)
Pars Distalis, Hyperplasia, Focal 5 (11%) 1 (17%) 6 (14%)
Pars Distalis, Hyperplasia, Multifocal 2 (4%)
Thyroid Gland (49) (4) (3) (49)
Necrosis, Acute, Focal 1 (2%)
Follicular Cell, Hyperplasia 1 (2%)
Follicular Cell, Hyperplasia, Focal 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia, Multifocal 1 (2%)
Interstitium, Inflammation, Chronic, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (50) (14) (17) (47)
Angiectasis, Focal 1 (2%)
Angiectasis, Multifocal 1 (2%) 1 (6%)
Inflammation, Chronic, Multifocal,
Suppurative 2 (4%)
Thrombosis, Chronic Active 1 (2%) 1 (7%)
Corpus Luteum, Angiectasis, Multifocal 1 (2%)
Follicle, Cyst 10 (20%) 7 (50%) 11 (65%) 14 (30%)
Follicle, Cyst, Multiple 3 (6%) 1 (2%)
Periovarian Tissue, Cyst 3 (6%) 1 (7%) 5 (29%) 1 (2%)
Periovarian Tissue, Infiltration Cellular,
Multifocal, Lymphocyte 1 (2%)
Periovarian Tissue, Inflammation, Chronic
Active, Multifocal 1 (7%)
Rete Ovarii, Cyst 1 (2%)
Uterus (50) (38) (42) (48)
Inflammation, Chronic, Multifocal,
Suppurative 1 (3%) 2 (4%)
Endometrium, Angiectasis, Multifocal 1 (2%)
Endometrium, Hyperplasia, Cystic, Glandular,
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05020-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 19:58:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Multifocal 45 (90%) 35 (92%) 41 (98%) 43 (90%)
Mucosa, Metaplasia, Multifocal, Squamous 1 (2%)
Myometrium, Angiectasis, Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (1) (2) (3)
Neutrophilia 3 (100%)
Bone Marrow (48) (5) (3) (49)
Femoral, Angiectasis, Focal 1 (2%)
Femoral, Hyperplasia, Diffuse, Neutrophil 2 (4%)
Femoral, Myelofibrosis, Multifocal 3 (6%) 4 (8%)
Lymph Node (48) (5) (7) (47)
Mediastinal, Hyperplasia, Diffuse, Lymphoid 2 (4%)
Pancreatic, Inflammation, Chronic Active,
Multifocal 1 (14%)
Renal, Hyperplasia, Diffuse, Lymphoid 1 (2%)
Lymph Node, Mandibular (46) (5) (5) (47)
Hyperplasia, Diffuse, Lymphoid 1 (2%)
Hyperplasia, Multifocal, Plasma Cell 1 (2%)
Lymphatic, Angiectasis, Diffuse 1 (20%)
Lymph Node, Mesenteric (8) (4) (3)
Cyst 1 (25%)
Hematopoietic Cell Proliferation, Multifocal 1 (25%)
Lymphatic, Ectasia, Focal 1 (13%)
Spleen (50) (50) (50) (49)
Capsule, Hyperplasia, Multifocal 1 (2%)
Capsule, Inflammation, Chronic Active,
Multifocal 1 (2%)
Lymphoid Follicle, Necrosis, Acute,
Multifocal 1 (2%) 2 (4%)
Red Pulp, Hematopoietic Cell Proliferation,
Diffuse 48 (96%) 50 (100%) 49 (98%) 48 (98%)
Red Pulp, Pigmentation, Hemosiderin,
Multifocal 45 (90%) 47 (94%) 49 (98%) 49 (100%)
Thymus (41) (4) (1) (35)
Depletion Lymphoid, Multifocal 1 (3%)
Necrosis, Acute, Multifocal 1 (2%) 3 (75%)
Medulla, Thymocyte, Hyperplasia, Diffuse 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05020-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 19:58:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (38) (5) (3) (44)
Hyperplasia, Cystic, Multifocal 2 (67%)
Skin (50) (7) (7) (49)
Parasite External 3 (6%)
Ulcer 2 (29%)
Subcutaneous Tissue, Fibrosis, Multifocal 1 (14%)
Subcutaneous Tissue, Inflammation, Chronic
Active, Multifocal 2 (29%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (6) (3) (50)
Bilateral, Joint, Tarsal, Hyperostosis 1 (2%)
Bilateral, Joint, Tarsal, Metaplasia,
Multifocal, Osseous 1 (2%)
Cranium, Fibrous Osteodystrophy 1 (2%)
Cranium, Hyperostosis, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (48) (5) (3) (49)
Hemorrhage, Multifocal 1 (2%)
Necrosis, Acute, Multifocal 1 (33%)
Hypothalamus, Compression, Focal 1 (2%)
Meninges, Infiltration Cellular, Multifocal,
Lymphocyte 1 (2%) 2 (4%)
Meninges, Inflammation, Chronic Active,
Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (8) (7) (50)
Alveolar Epithelium, Hyperplasia, Focal 1 (13%) 3 (6%)
Alveolus, Hemorrhage, Multifocal 1 (14%) 1 (2%)
Interstitium, Inflammation, Chronic,
Multifocal 2 (4%)
Interstitium, Inflammation, Chronic Active,
Focal 1 (2%)
Interstitium, Inflammation, Chronic Active,
Multifocal 1 (2%)
Mediastinum, Foreign Body, Multifocal 1 (2%) 3 (38%)
Perivascular, Hyperplasia, Lymphoid,
Multifocal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05020-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 19:58:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Perivascular, Inflammation, Chronic,
Multifocal 1 (2%)
Pleura, Inflammation, Acute, Diffuse 1 (13%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1) (1)
Degeneration, Diffuse 1 (100%)
Cornea, Inflammation, Chronic Active,
Diffuse, Necrotizing 1 (100%)
Harderian Gland (48) (4) (3) (47)
Inflammation, Chronic Active, Diffuse 1 (2%)
Acinus, Hyperplasia, Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (7) (4) (49)
Inflammation, Chronic Active, Multifocal 1 (25%)
Mineralization, Multifocal 1 (2%)
Nephropathy, Chronic, Diffuse 1 (2%)
Nephropathy, Chronic, Focal 3 (6%) 1 (2%)
Nephropathy, Chronic, Multifocal 1 (2%) 1 (2%)
Capsule, Fibrosis, Chronic, Focal 1 (25%)
Glomerulus, Amyloid Deposition, Multifocal 1 (2%)
Glomerulus, Inflammation, Chronic, Multifocal 3 (6%)
Perivascular, Infiltration Cellular,
Multifocal, Plasma Cell 1 (2%)
Renal Tubule, Cytoplasmic Alteration, Diffuse 1 (14%)
Renal Tubule, Dilatation, Diffuse 1 (2%)
Renal Tubule, Pigmentation, Hemosiderin,
Multifocal 38 (78%)
Renal Tubule, Regeneration, Focal 3 (6%)
Renal Tubule, Regeneration, Multifocal 4 (8%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05020-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 19:58:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund 3 6 12 9
Dead 4 7 9 6
Survivors
Terminal Sacrifice 43 36 29 35
Missing 1
Animals Examined Microscopically 50 49 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (45) (4) (47)
Necrosis, Acute, Multifocal 1 (25%)
Lumen, Crystals, Diffuse 1 (2%)
Submucosa, Fibrosis, Diffuse 1 (25%)
Intestine Large, Colon (48) (6) (7) (48)
Inflammation, Acute, Multifocal, Necrotizing 1 (17%)
Parasite Metazoan 1 (17%) 3 (6%)
Intestine Large, Rectum (46) (1) (5) (50)
Parasite Metazoan 2 (4%)
Liver (50) (49) (50) (50)
Amyloid Deposition, Multifocal 1 (2%)
Angiectasis, Focal 1 (2%) 2 (4%)
Angiectasis, Multifocal 3 (6%)
Clear Cell Focus, Focal 1 (2%)
Cyst 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation, Diffuse 1 (2%) 2 (4%)
Hematopoietic Cell Proliferation, Focal 1 (2%)
Hematopoietic Cell Proliferation, Multifocal 6 (12%) 4 (8%) 6 (12%) 3 (6%)
Inflammation 1 (2%)
Inflammation, Acute, Multifocal 1 (2%)
Inflammation, Chronic, Multifocal 2 (4%)
Inflammation, Chronic Active, Multifocal 1 (2%)
Necrosis, Acute, Multifocal 1 (2%)
Necrosis, Chronic Active, Focal 1 (2%)
Necrosis, Chronic Active, Multifocal 1 (2%) 1 (2%) 6 (12%)
Necrosis, Coagulative, Focal 1 (2%)
Thrombosis, Chronic 2 (4%)
Vacuolization Cytoplasmic, Focal 1 (2%)
Bile Duct, Hyperplasia, Multifocal 2 (4%)
Centrilobular, Necrosis, Acute, Multifocal 1 (2%)
Centrilobular, Vacuolization Cytoplasmic,
Diffuse 4 (8%) 4 (8%)
Hepatocyte, Cytomegaly, Diffuse 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05020-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 19:58:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hepatocyte, Hyperplasia, Focal 1 (2%)
Kupffer Cell, Pigmentation, Hemosiderin 50 (100%)
Pancreas (49) (3) (7) (49)
Inflammation, Chronic, Multifocal 1 (2%)
Acinus, Atrophy, Focal 1 (2%)
Acinus, Atrophy, Multifocal 6 (12%) 4 (8%)
Tooth (50) (5) (7) (50)
Incisor, Dysplasia, Multifocal 1 (2%)
Molar, Dysplasia 1 (2%) 1 (2%)
Peridontal Tissue, Foreign Body, Focal 2 (4%)
Peridontal Tissue, Foreign Body, Multifocal 1 (2%)
Peridontal Tissue, Inflammation, Chronic
Active, Focal 3 (6%) 4 (8%)
Peridontal Tissue, Inflammation, Chronic
Active, Multifocal 6 (12%) 3 (6%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (5) (8) (50)
Coronary Artery, Inflammation, Chronic
Active, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (49) (5) (7) (50)
Capsule, Ectopic Tissue 2 (4%)
Capsule, Hyperplasia, Focal 2 (4%) 1 (20%) 1 (2%)
Capsule, Hyperplasia, Multifocal 44 (90%) 1 (20%) 4 (57%) 44 (88%)
Adrenal Gland, Cortex (49) (5) (7) (50)
Cyst 2 (4%)
Hyperplasia, Focal 11 (22%) 5 (10%)
Hyperplasia, Multifocal 1 (2%)
Hypertrophy, Focal 9 (18%) 10 (20%)
Hypertrophy, Multifocal 5 (10%)
Necrosis, Acute, Focal 1 (2%)
Vacuolization Cytoplasmic, Focal 1 (2%)
Adrenal Gland, Medulla (49) (4) (7) (50)
Hyperplasia, Focal 1 (2%)
Parathyroid Gland (36) (4) (1) (38)
Cyst 1 (3%)
Pituitary Gland (40) (4) (4) (41)
Pars Distalis, Cyst 1 (3%) 2 (5%)
Pars Distalis, Cyst, Multiple 1 (2%)
Pars Distalis, Hyperplasia, Focal 1 (2%)
Thyroid Gland (50) (5) (7) (48)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05020-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 19:58:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Inflammation, Chronic Active, Multifocal 1 (2%)
Follicle, Cyst, Multiple 1 (2%)
Follicular Cell, Hyperplasia, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (5) (7) (49)
Infiltration Cellular, Multifocal, Lymphocyte 2 (4%)
Inflammation, Chronic, Multifocal 1 (2%)
Inflammation, Chronic Active, Multifocal 4 (8%)
Penis (1) (2)
Concretion, Chronic Active, Multifocal 1 (100%)
Inflammation, Chronic Active, Multifocal 1 (100%)
Preputial Gland (2) (3) (5) (5)
Atrophy, Diffuse 2 (100%)
Atrophy, Multifocal 1 (20%) 1 (20%)
Inflammation, Chronic Active, Diffuse 1 (50%)
Inflammation, Chronic Active, Multifocal 2 (67%) 1 (20%) 1 (20%)
Inflammation, Multifocal, Suppurative 2 (40%)
Duct, Dilatation, Focal 1 (33%) 1 (20%)
Duct, Dilatation, Multifocal 1 (50%) 2 (40%)
Prostate (48) (4) (7) (50)
Inflammation, Acute, Diffuse 1 (2%)
Inflammation, Chronic Active, Multifocal 1 (25%) 1 (2%)
Epithelium, Hyperplasia, Focal 1 (2%)
Testes (49) (5) (7) (50)
Germinal Epithelium, Degeneration, Chronic,
Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (2) (2)
Neutrophilia 2 (100%) 1 (50%)
Bone Marrow (50) (3) (7) (50)
Hyperplasia, Diffuse, Neutrophil 3 (6%) 1 (14%) 5 (10%)
Hyperplasia, Multifocal, Neutrophil 1 (2%)
Thrombosis, Chronic Active 1 (2%)
Femoral, Angiectasis, Focal 2 (4%)
Lymph Node (49) (25) (28) (49)
Mediastinal, Hematopoietic Cell
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05020-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 19:58:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Proliferation, Diffuse 1 (2%)
Mediastinal, Hematopoietic Cell
Proliferation, Multifocal 2 (4%) 1 (2%)
Pancreatic, Hematopoietic Cell Proliferation,
Multifocal 1 (2%)
Renal, Hyperplasia, Multifocal, Plasma Cell 1 (2%)
Lymph Node, Mandibular (48) (8) (9) (49)
Depletion Lymphoid, Diffuse 1 (13%)
Hematopoietic Cell Proliferation, Multifocal 1 (2%)
Hyperplasia, Lymphoid, Multifocal 2 (4%) 3 (38%) 1 (11%)
Hyperplasia, Multifocal, Plasma Cell 2 (4%) 1 (11%) 3 (6%)
Lymphocyte, Necrosis, Multifocal 1 (2%)
Lymph Node, Mesenteric (22) (19) (20) (17)
Angiectasis, Multifocal 1 (5%)
Hematocyst, Chronic Active 1 (6%)
Hematopoietic Cell Proliferation, Multifocal 10 (45%) 18 (95%) 18 (90%) 14 (82%)
Hemorrhage, Multifocal 4 (18%)
Hyperplasia, Diffuse, Lymphoid 1 (5%)
Hyperplasia, Lymphoid, Multifocal 1 (6%)
Inflammation, Chronic, Multifocal 1 (6%)
Inflammation, Focal, Granulomatous 1 (5%)
Inflammation, Multifocal, Suppurative 1 (5%)
Spleen (50) (47) (49) (49)
Amyloid Deposition, Multifocal 1 (2%)
Angiectasis, Focal 1 (2%) 2 (4%)
Angiectasis, Multifocal 1 (2%)
Lymphoid Follicle, Depletion Lymphoid,
Multifocal 1 (2%)
Lymphoid Follicle, Necrosis, Acute,
Multifocal 1 (2%)
Red Pulp, Angiectasis, Focal 1 (2%)
Red Pulp, Fibrosis 1 (2%)
Red Pulp, Fibrosis, Multifocal 1 (2%) 1 (2%)
Red Pulp, Hematopoietic Cell Proliferation,
Diffuse 50 (100%) 47 (100%) 49 (100%) 48 (98%)
Red Pulp, Pigmentation, Hemosiderin,
Multifocal 37 (74%) 47 (100%) 45 (92%) 48 (98%)
Thymus (36) (3) (27)
Cyst, Multiple 1 (4%)
Depletion Lymphoid, Multifocal 1 (4%)
Necrosis, Acute, Multifocal 1 (3%) 2 (7%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05020-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 19:58:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (49) (27) (28) (49)
Acanthosis, Diffuse 1 (2%) 3 (11%) 5 (18%) 4 (8%)
Acanthosis, Focal 2 (7%) 1 (2%)
Acanthosis, Multifocal 9 (18%) 4 (15%) 2 (7%) 7 (14%)
Alopecia 1 (2%)
Hyperkeratosis, Multifocal 1 (2%) 1 (2%)
Inflammation, Chronic Active, Multifocal 1 (4%)
Parasite External 7 (14%) 12 (24%)
Ulcer 6 (12%) 9 (33%) 8 (29%) 5 (10%)
Ulcer, Multiple 4 (8%)
Sebaceous Gland, Hyperplasia, Focal 1 (4%)
Subcutaneous Tissue, Fibrosis, Diffuse 1 (2%) 1 (4%) 4 (14%) 3 (6%)
Subcutaneous Tissue, Fibrosis, Focal 1 (2%) 2 (7%) 1 (4%) 1 (2%)
Subcutaneous Tissue, Fibrosis, Multifocal 5 (10%) 4 (15%) 1 (4%) 2 (4%)
Subcutaneous Tissue, Inflammation, Acute,
Multifocal 1 (4%)
Subcutaneous Tissue, Inflammation, Chronic
Active, Diffuse 1 (4%) 2 (7%)
Subcutaneous Tissue, Inflammation, Chronic
Active, Focal 2 (7%) 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic
Active, Multifocal 2 (4%) 5 (19%) 1 (4%) 7 (14%)
Subcutaneous Tissue, Inflammation, Multifocal 1 (4%)
Subcutaneous Tissue, Mineralization,
Multifocal 1 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (28) (26) (50)
Bilateral, Joint, Radius, Hyperostosis 1 (2%)
Bilateral, Joint, Tarsal, Hyperostosis 10 (20%) 21 (75%) 16 (62%) 11 (22%)
Bilateral, Joint, Tarsal, Metaplasia,
Multifocal, Osseous 10 (20%) 21 (75%) 16 (62%) 11 (22%)
Joint, Tarsal, Hyperostosis 11 (22%) 2 (7%) 4 (15%) 9 (18%)
Joint, Tarsal, Metaplasia, Multifocal,
Osseous 11 (22%) 2 (7%) 4 (15%) 9 (18%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05020-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 19:58:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (10) (14) (50)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%) 1 (7%) 4 (8%)
Interstitium, Inflammation, Acute, Diffuse 1 (2%)
Interstitium, Inflammation, Acute, Multifocal 1 (2%)
Interstitium, Inflammation, Chronic Active,
Focal 1 (2%)
Interstitium, Inflammation, Chronic Active,
Multifocal 1 (2%) 1 (10%)
Nose (50) (5) (7) (50)
Respiratory Epithelium, Inflammation, Acute,
Multifocal 1 (14%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1) (3)
Cataract 1 (50%) 1 (33%)
Inflammation, Chronic, Multifocal 1 (33%)
Lens, Cataract, Multifocal 1 (100%)
Retina, Atrophy, Multifocal 1 (100%)
Harderian Gland (50) (5) (7) (40)
Inflammation, Chronic Active, Multifocal 1 (14%)
Acinus, Dilatation, Diffuse 1 (2%)
Acinus, Hyperplasia, Multifocal 1 (3%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (6) (10) (49)
Amyloid Deposition, Multifocal 1 (10%)
Cyst 1 (2%)
Infarct, Chronic, Focal 1 (17%) 1 (10%)
Inflammation, Acute, Multifocal, Suppurative 3 (50%)
Mineralization, Focal 1 (17%)
Nephropathy, Chronic, Focal 3 (6%) 1 (2%)
Nephropathy, Chronic, Multifocal 2 (4%) 3 (30%) 7 (14%)
Bilateral, Hydronephrosis, Acute, Multifocal 1 (2%)
Cortex, Inflammation, Chronic, Multifocal 1 (2%)
Perivascular, Infiltration Cellular,
Multifocal, Lymphocyte 1 (2%)
Renal Tubule, Atypia Cellular, Multifocal 1 (2%)
Renal Tubule, Degeneration, Multifocal 1 (2%)
Renal Tubule, Pigmentation, Hemosiderin,
Multifocal 4 (8%)
Renal Tubule, Regeneration, Focal 1 (2%)
Renal Tubule, Regeneration, Multifocal 33 (66%) 30 (61%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05020-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 19:58:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Urinary Bladder (49) (8) (11) (50)
Dilatation 1 (2%) 4 (36%)
Dilatation, Diffuse 7 (88%)
Submucosa, Congestion, Multifocal 1 (2%)
Submucosa, Necrosis, Acute, Multifocal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
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