Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/2864

TR 351 Mouse Pathology Tables

NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97
Route: GAVAGE                                                                                                     Time: 14:10:11




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  106-47-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 3| 2| 2| 3| 2| 2| 3| 2| 3| 2| 2| 2| 3| 2| 6| 8| 1| 3| 2|             
                                           | 3| 8| 8| 7| 9| 1| 0| 9| 8| 0| 8| 8| 2| 8| 1| 9| 8| 8| 0| 9| 6| 0| 7| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                                          |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                              X                           |             
      Hepatocellular Carcinoma             |                                                                X         |             
      Hepatocellular Adenoma               |                                           X                          X   |             
      Lymphoma Malignant Histiocytic       | X                                                                        |             
      Lymphoma Malignant Lymphocytic       |                               X                             X           X|             
      Lymphoma Malignant Mixed             |                                                                   X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Lymphoma Malignant Histiocytic       | X                                                                        |             
      Lymphoma Malignant Lymphocytic       |                               X                             X            |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                               X                             X           X|             
      Lymphoma Malignant Mixed             |                                                                   X      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
      Squamous Cell Papilloma              |       X                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 3| 2| 2| 3| 2| 2| 3| 2| 3| 2| 2| 2| 3| 2| 6| 8| 1| 3| 2|             
                                           | 3| 8| 8| 7| 9| 1| 0| 9| 8| 0| 8| 8| 2| 8| 1| 9| 8| 8| 0| 9| 6| 0| 7| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Adenoma                     |                X           X                                             |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  M  +  +  +  +  +  M  +  M  +  M  +  +  M  +  +  M  M  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Pars Distalis, Adenoma               |                      X                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Follicular Cell, Adenoma             |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |       X                                                                  |             
      Granulosa Cell Tumor Benign          |                                                                      X   |             
      Lymphoma Malignant Histiocytic       | X                                                                        |             
      Lymphoma Malignant Lymphocytic       |                               X                             X     X      |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Follicle, Adenoma                    |                                                          X               |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Lymphocytic            |                                                                         X|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                  X                                       |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
      Polyp Stromal                        |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                             +            |             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       | X                                                                        |             
      Femoral, Lymphoma Malignant          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 3| 2| 2| 3| 2| 2| 3| 2| 3| 2| 2| 2| 3| 2| 6| 8| 1| 3| 2|             
                                           | 3| 8| 8| 7| 9| 1| 0| 9| 8| 0| 8| 8| 2| 8| 1| 9| 8| 8| 0| 9| 6| 0| 7| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Lymphocytic                      |                                                             X            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Histiocytic                      | X                                                                        |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                               X                             X            |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      | X                                                                        |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                               X                             X            |             
      Mediastinal, Lymphoma Malignant Mixed|                            X                                             |             
      Renal, Fibrosarcoma, Metastatic, Skin|          X                                                               |             
      Renal, Lymphoma Malignant Histiocytic|                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                             X            |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       | X                                                                        |             
      Lymphoma Malignant Lymphocytic       |                               X                             X           X|             
      Lymphoma Malignant Mixed             |                            X                                      X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  +  M  +  M  M|             
      Lymphoma Malignant Histiocytic       | X                                                                        |             
      Lymphoma Malignant Lymphocytic       |                               X                             X            |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                  X                                       |             
      Lymphoma Malignant Histiocytic       | X                                                                        |             
      Lymphoma Malignant Lymphocytic       |                               X                             X           X|             
      Lymphoma Malignant Mixed             |                            X              X                       X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                             X           X|             
      Lymphoma Malignant Mixed             |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibrosarcoma    |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 3| 2| 2| 3| 2| 2| 3| 2| 3| 2| 2| 2| 3| 2| 6| 8| 1| 3| 2|             
                                           | 3| 8| 8| 7| 9| 1| 0| 9| 8| 0| 8| 8| 2| 8| 1| 9| 8| 8| 0| 9| 6| 0| 7| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                             +            |             
      Abdominal, Lymphoma Malignant        |                                                                          |             
          Lymphocytic                      |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Choroid Plexus, Lymphoma Malignant   |                                                                          |             
          Lymphocytic                      |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                         X        X                          X        X   |             
      Alveolar/Bronchiolar Carcinoma       |                   X                                                      |             
      Fibrosarcoma, Metastatic, Skin       |          X                                                               |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                               X                             X            |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Adenoma                              |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                               X                             X           X|             
      Lymphoma Malignant Mixed             |                                                                   X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |          X                                                               |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                               X                             X            |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 3| 2| 2| 3| 2| 2| 3| 2| 3| 2| 2| 2| 3| 2| 6| 8| 1| 3| 2|             
                                           | 3| 8| 8| 7| 9| 1| 0| 9| 8| 0| 8| 8| 2| 8| 1| 9| 8| 8| 0| 9| 6| 0| 7| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Histiocytic       | X                                                                        |             
      Lymphoma Malignant Lymphocytic       |                               X                             X     X     X|             
      Lymphoma Malignant Mixed             |                            X              X                       X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 0| 3| 2| 3| 7| 3| 2| 9| 9| 2| 3| 3| 2| 3| 2| 4| 2| 3| 2| 3| 2|            |
                                           | 0| 4| 2| 2| 1| 1| 9| 0| 2| 0| 8| 5| 5| 8| 0| 0| 8| 1| 8| 3| 9| 2| 8| 0| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Lymphocytic                      | X                                                                        |          1 |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                         X                                                |          1 |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Undifferentiated Cell Type       |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Hepatocellular Adenoma               |                   X     X                                         X      |          5 |
      Lymphoma Malignant Histiocytic       |    X                             X                                       |          3 |
      Lymphoma Malignant Lymphocytic       |                                                                   X  X  X|          6 |
      Lymphoma Malignant Mixed             |                         X                             X                  |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +                                                |   2        |
      Lymphoma Malignant Mixed             |                         X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Histiocytic       |    X                                                                     |          2 |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoma Malignant Histiocytic       |    X                                                                     |          1 |
      Lymphoma Malignant Lymphocytic       | X     X                                                              X   |          6 |
      Lymphoma Malignant Mixed             |                         X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Squamous Cell Papilloma              |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   7                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 0| 3| 2| 3| 7| 3| 2| 9| 9| 2| 3| 3| 2| 3| 2| 4| 2| 3| 2| 3| 2|            |
                                           | 0| 4| 2| 2| 1| 1| 9| 0| 2| 0| 8| 5| 5| 8| 0| 0| 8| 1| 8| 3| 9| 2| 8| 0| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Capsule, Adenoma                     |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pheochromocytoma Benign              |                   X                                X                     |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  M  +  +  +  +  +|  37        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Pars Distalis, Adenoma               | X        X                                                               |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Follicular Cell, Adenoma             |                      X                             X                     |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cystadenoma                          |                                                                          |          1 |
      Granulosa Cell Tumor Benign          |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |    X                                                                     |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          3 |
      Lymphoma Malignant Mixed             |                         X                                                |          1 |
      Follicle, Adenoma                    |                                                                          |          1 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Lymphocytic            |                                                                      X   |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangioma                           |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |    X                                                                     |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 0| 3| 2| 3| 7| 3| 2| 9| 9| 2| 3| 3| 2| 3| 2| 4| 2| 3| 2| 3| 2|            |
                                           | 0| 4| 2| 2| 1| 1| 9| 0| 2| 0| 8| 5| 5| 8| 0| 0| 8| 1| 8| 3| 9| 2| 8| 0| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Polyp Stromal                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  A  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Histiocytic                      |    X                                                                     |          2 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                                                          |          2 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |    X                                                                     |          2 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      | X     X                                                              X   |          5 |
      Mediastinal, Lymphoma Malignant Mixed|                         X           X                                    |          3 |
      Renal, Fibrosarcoma, Metastatic, Skin|                                                                          |          1 |
      Renal, Lymphoma Malignant Histiocytic|                                  X                                       |          1 |
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +|  46        |
      Lymphoma Malignant Histiocytic       |    X                                                                     |          2 |
      Lymphoma Malignant Lymphocytic       | X     X                       X                                   X  X  X|          9 |
      Lymphoma Malignant Mixed             |                         X           X                 X                  |          5 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  M  M  M  M  M  +  M  +  M  M  +  +  M  M  M  M  M  M  M  M  M  M  M  M|   8        |
      Lymphoma Malignant Histiocytic       |                                  X                                       |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                         X           X                                    |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   9                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 0| 3| 2| 3| 7| 3| 2| 9| 9| 2| 3| 3| 2| 3| 2| 4| 2| 3| 2| 3| 2|            |
                                           | 0| 4| 2| 2| 1| 1| 9| 0| 2| 0| 8| 5| 5| 8| 0| 0| 8| 1| 8| 3| 9| 2| 8| 0| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Histiocytic       |    X                             X                                       |          3 |
      Lymphoma Malignant Lymphocytic       | X     X                       X                                   X  X  X|          9 |
      Lymphoma Malignant Mixed             |                         X           X                 X                  |          6 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  M  +  +  M  M  +|  41        |
      Lymphoma Malignant Histiocytic       |    X                                                                     |          1 |
      Lymphoma Malignant Lymphocytic       |       X                                                                 X|          4 |
      Lymphoma Malignant Mixed             |                         X           X                 X                  |          4 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  M  M  +  +  M  +  +  M  +  +  +  +  +  M  +  M  +  +  +|  38        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Abdominal, Lymphoma Malignant        |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Choroid Plexus, Lymphoma Malignant   |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         | X                                                                        |          5 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |    X                                                                     |          1 |
      Lymphoma Malignant Lymphocytic       |       X                                                           X     X|          5 |
      Lymphoma Malignant Mixed             |                         X                             X                  |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 0| 3| 2| 3| 7| 3| 2| 9| 9| 2| 3| 3| 2| 3| 2| 4| 2| 3| 2| 3| 2|            |
                                           | 0| 4| 2| 2| 1| 1| 9| 0| 2| 0| 8| 5| 5| 8| 0| 0| 8| 1| 8| 3| 9| 2| 8| 0| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Adenoma                              |                   X                             X                        |          3 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |    X                                                                     |          1 |
      Lymphoma Malignant Lymphocytic       | X                             X                                   X     X|          7 |
      Lymphoma Malignant Mixed             |                         X                             X                  |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |    X                                                                     |          1 |
      Lymphoma Malignant Lymphocytic       | X     X                                                                  |          4 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |    X                             X                                       |          3 |
      Lymphoma Malignant Lymphocytic       | X     X                       X                                   X  X  X|         10 |
      Lymphoma Malignant Mixed             |                         X           X                 X                  |          6 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  11                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 0| 7| 0| 7| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 1| 2| 0| 3| 0| 3| 2| 3| 3| 3| 0| 3| 8| 2| 3| 3| 3| 0| 2| 3| 2| 3| 2| 2|             
                                           | 9| 4| 8| 1| 1| 1| 1| 8| 1| 2| 1| 2| 1| 2| 9| 0| 1| 2| 9| 9| 0| 8| 2| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    3 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Gallbladder                             |       +  +     +                 A                                       |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +     +                 M                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +     +                 M                                       |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +     +                 A                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  +     +                 A                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +     +                 A                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +     +                 A                                       |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |             X                                                            |             
      Hepatocellular Adenoma               |                                           X              X        X      |             
      Hepatocellular Adenoma, Multiple     |                                                    X                     |             
      Lymphoma Malignant Histiocytic       |       X                                                                  |             
      Lymphoma Malignant Lymphocytic       |                                           X     X        X               |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                   +                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +     +                 +     +                                 |             
      Lymphoma Malignant Histiocytic       |       X                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +     +                 +                                       |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Tooth                                   |       +  +     +                 +                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +     +                 +                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +  +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +  +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +  +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +  M     M                 M                                       |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +     +                 M                                       |             
      Pars Distalis, Adenoma               |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +     M                 +                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 0| 7| 0| 7| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 1| 2| 0| 3| 0| 3| 2| 3| 3| 3| 0| 3| 8| 2| 3| 3| 3| 0| 2| 3| 2| 3| 2| 2|             
                                           | 9| 4| 8| 1| 1| 1| 1| 8| 1| 2| 1| 2| 1| 2| 9| 0| 1| 2| 9| 9| 0| 8| 2| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    3 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +     +           +     +                    +        +         |             
      Lymphoma Malignant Histiocytic       |       X                                                                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +  +     +  +  +        +  +  +  +  +  +  +  +  +  +  +  +        +|             
      Lymphoma Malignant Histiocytic       |       X                                                                  |             
      Polyp Stromal                        |                                                                          |             
      Cervix, Lymphoma Malignant           |                                                                          |             
          Histiocytic                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +  +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       M  M     M                 M                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                      X   |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                           X     X        X               |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Thymus                                  |       M  +     +                 +                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  M     +              +  M                                      +|             
      Adenocarcinoma                       |                                                                         X|             
      Adenoma                              |                               X                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +     +              +  +                                      +|             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Histiocytic            |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +     +                 +                                       |             
      Cranium, Osteoma                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +     +                 +                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +     +           +     +                                   +   |             
      Alveolar/Bronchiolar Adenoma         |                                                                      X   |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +     +                 +                                       |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 0| 7| 0| 7| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 1| 2| 0| 3| 0| 3| 2| 3| 3| 3| 0| 3| 8| 2| 3| 3| 3| 0| 2| 3| 2| 3| 2| 2|             
                                           | 9| 4| 8| 1| 1| 1| 1| 8| 1| 2| 1| 2| 1| 2| 9| 0| 1| 2| 9| 9| 0| 8| 2| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    3 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                                                   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +  +     M     +           M                                       |             
      Adenoma                              |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +     +                 +                       +               |             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +     +                 +                                       |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |       X                                                                  |             
      Lymphoma Malignant Lymphocytic       |                                           X     X        X               |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 2| 3| 2| 2| 3| 3| 3| 3| 2| 3| 2| 2| 3| 2| 2| 3| 3| 3| 2| 2| 3|            |
                                           | 8| 0| 2| 1| 9| 2| 8| 8| 1| 1| 2| 2| 9| 2| 9| 9| 2| 9| 9| 9| 1| 2| 8| 8| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     A      |
    3 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                          +               |   5        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                          A               |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                          +               |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                          +               |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                          +               |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                          +               |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                          +               |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                          +               |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                          +               |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                          +               |   4        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |                                  X                                       |          2 |
      Hepatocellular Adenoma               |                                                 X     X        X         |          6 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |       X                                                                  |          2 |
      Lymphoma Malignant Lymphocytic       |                                                       X                  |          4 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                  +                       +               |   7        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                          +               |   5        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                          +               |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                          +               |   5        |
      Squamous Cell Papilloma              |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                          +               |   5        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                          +               |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                          +               |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                          +               |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                          +               |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                          +               |   5        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                          +               |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                          +               |   2        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          M        +                                      +               |   5        |
      Pars Distalis, Adenoma               |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                          +               |   4        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  15                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 2| 3| 2| 2| 3| 3| 3| 3| 2| 3| 2| 2| 3| 2| 2| 3| 3| 3| 2| 2| 3|            |
                                           | 8| 0| 2| 1| 9| 2| 8| 8| 1| 1| 2| 2| 9| 2| 9| 9| 2| 9| 9| 9| 1| 2| 8| 8| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     A      |
    3 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                +                 +                       +     +  +      |  14        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +        +     +  +  +  +     +  +  +  +  +     +  +  +  +     +  +|  38        |
      Lymphoma Malignant Histiocytic       |                                     X                                    |          2 |
      Polyp Stromal                        |                                                             X            |          1 |
      Cervix, Lymphoma Malignant           |                                                                          |            |
          Histiocytic                      |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                          +               |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                          +               |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                          +               |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                          M               |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |       X                                                                  |          1 |
      Lymphoma Malignant Lymphocytic       |             X  X                       X              X                 X|          8 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                          +               |   4        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                          +               |   5        |
      Adenocarcinoma                       |                                                                          |          1 |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                          +               |   7        |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant Histiocytic            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                          +        +      |   6        |
      Cranium, Osteoma                     |                                                                   X      |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                          +               |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  16                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 2| 3| 2| 2| 3| 3| 3| 3| 2| 3| 2| 2| 3| 2| 2| 3| 3| 3| 2| 2| 3|            |
                                           | 8| 0| 2| 1| 9| 2| 8| 8| 1| 1| 2| 2| 9| 2| 9| 9| 2| 9| 9| 9| 1| 2| 8| 8| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     A      |
    3 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                  +                       +               |   8        |
      Alveolar/Bronchiolar Adenoma         |                                  X                                       |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                  X                                       |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                          +               |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                          +               |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                          +               |   4        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                +                                         +               |   7        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                          +               |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |       X                             X                                    |          3 |
      Lymphoma Malignant Lymphocytic       |             X  X                       X              X                 X|          8 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  17                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 3| 3| 3| 3| 3| 6| 2| 0| 2| 2| 3| 2| 3| 5| 3| 0| 2| 3| 2| 2| 3|             
                                           | 1| 9| 8| 8| 1| 2| 2| 2| 0| 7| 9| 4| 9| 8| 2| 8| 1| 0| 2| 9| 9| 2| 8| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                  X                                       |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                              X                           |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Carcinoma, Multiple   |                                                 X                        |             
      Hepatocellular Adenoma               |                               X                 X                       X|             
      Lymphoma Malignant Histiocytic       |                                                          X               |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                          X               |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                          X               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  M  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  M  +  +  I|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 3| 3| 3| 3| 3| 6| 2| 0| 2| 2| 3| 2| 3| 5| 3| 0| 2| 3| 2| 2| 3|             
                                           | 1| 9| 8| 8| 1| 2| 2| 2| 0| 7| 9| 4| 9| 8| 2| 8| 1| 0| 2| 9| 9| 2| 8| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma               |                                              X  X                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                X                             X                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                                                          |             
      Fibrosarcoma, Metastatic, Skin       |                            X                                             |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Mixed                  |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |          +                       +                                       |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchial, Lymphoma Malignant        |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Bronchial, Lymphoma Malignant Mixed  |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |             
      Mediastinal, Fibrosarcoma,           |                                                                          |             
          Metastatic, Skin                 |                      X                                                   |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                          X               |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                          X               |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M|             
      Lymphoma Malignant Mixed             |                                              X                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                          X               |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                              X                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  M  +  +  +  M  +  M  +  M  +  +  +  M  +  +  +  M  +  +  +  M  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 3| 3| 3| 3| 3| 6| 2| 0| 2| 2| 3| 2| 3| 5| 3| 0| 2| 3| 2| 2| 3|             
                                           | 1| 9| 8| 8| 1| 2| 2| 2| 0| 7| 9| 4| 9| 8| 2| 8| 1| 0| 2| 9| 9| 2| 8| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibrosarcoma    |                      X     X                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sacrum, Osteosarcoma                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                           X                              |             
      Alveolar/Bronchiolar Carcinoma       |                                        X                                 |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                 X                        |             
      Lymphoma Malignant Histiocytic       |                                                          X               |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Mediastinum, Fibrosarcoma,           |                                                                          |             
          Metastatic, Skin                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              I     +                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Adenoma                              |          X                                            X                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  A  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                  X                       X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 3| 3| 3| 3| 3| 6| 2| 0| 2| 2| 3| 2| 3| 5| 3| 0| 2| 3| 2| 2| 3|             
                                           | 1| 9| 8| 8| 1| 2| 2| 2| 0| 7| 9| 4| 9| 8| 2| 8| 1| 0| 2| 9| 9| 2| 8| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 5| 1| 2| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2|            |
                                           | 1| 2| 8| 6| 9| 2| 1| 0| 0| 1| 1| 0| 9| 2| 7| 2| 0| 8| 1| 1| 0| 2| 1| 2| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    30 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                    X                     |          1 |
      Hepatocellular Carcinoma             |          X                       X                 X                     |          3 |
      Hepatocellular Carcinoma, Multiple   |                                                                   X      |          2 |
      Hepatocellular Adenoma               |    X                 X                 X              X           X      |          8 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                               X                                X         |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                       +                                          |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
      Lymphoma Malignant Mixed             |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                          X              X|          2 |
      Lymphoma Malignant Mixed             |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  A  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  22                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 5| 1| 2| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2|            |
                                           | 1| 2| 8| 6| 9| 2| 1| 0| 0| 1| 1| 0| 9| 2| 7| 2| 0| 8| 1| 1| 0| 2| 1| 2| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    30 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  42        |
      Pars Distalis, Adenoma               | X                                                                        |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Adenoma             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  I  +  +  A  M  +  +  +  +  +  +  +  +  +|  47        |
      Cystadenoma                          |                      X                                                   |          1 |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Mixed                  |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +|  48        |
      Polyp Stromal                        |                                                          X               |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                      +                                                   |   3        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Bronchial, Lymphoma Malignant        |                                                                          |            |
          Lymphocytic                      |                                                          X               |          1 |
      Bronchial, Lymphoma Malignant Mixed  |                               X                                          |          1 |
      Lumbar, Lymphoma Malignant Mixed     |                               X                                          |          1 |
      Mediastinal, Fibrosarcoma,           |                                                                          |            |
          Metastatic, Skin                 |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                         X|          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                X         |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  23                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 5| 1| 2| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2|            |
                                           | 1| 2| 8| 6| 9| 2| 1| 0| 0| 1| 1| 0| 9| 2| 7| 2| 0| 8| 1| 1| 0| 2| 1| 2| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    30 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                   X                                      X  X           X|          4 |
      Lymphoma Malignant Mixed             |                               X                                X         |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  M  M  M  M  M  M  M  M  M  +  M  M  M  A  M  M  M  M  M  M  M  M  M  M|   3        |
      Lymphoma Malignant Mixed             |                               X                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |             X     X                                      X  X           X|          5 |
      Lymphoma Malignant Mixed             |                               X                                X         |          3 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  M  +  +  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  M  +  +|  35        |
      Lymphoma Malignant Mixed             |                               X                                X         |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  M  +  +  +  M  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Subcutaneous Tissue, Fibrosarcoma    |                      X                                                   |          3 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Sacrum, Osteosarcoma                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                               X                                          |          2 |
      Alveolar/Bronchiolar Carcinoma       |                            X                                             |          2 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                  X                                       |          2 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                   X                                      X              X|          3 |
      Lymphoma Malignant Mixed             |                               X                                          |          1 |
      Mediastinum, Fibrosarcoma,           |                                                                          |            |
          Metastatic, Skin                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  24                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 5| 1| 2| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2|            |
                                           | 1| 2| 8| 6| 9| 2| 1| 0| 0| 1| 1| 0| 9| 2| 7| 2| 0| 8| 1| 1| 0| 2| 1| 2| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    30 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Adenoma                              |                                                 X                 X      |          4 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Lymphocytic       |             X                                            X  X            |          3 |
      Lymphoma Malignant Mixed             |                               X                                          |          1 |
      Renal Tubule, Adenoma                |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  I  +  +  +  +|  44        |
      Lymphoma Malignant Mixed             |                               X                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
      Lymphoma Malignant Lymphocytic       |             X     X                                      X  X           X|          5 |
      Lymphoma Malignant Mixed             |                               X                                X         |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  25                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 2| 3| 2| 3| 2| 2| 2| 2| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 2|             
                                           | 8| 0| 9| 2| 9| 0| 9| 5| 8| 9| 0| 8| 0| 0| 0| 2| 0| 9| 0| 1| 2| 1| 0| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                      +                                                   |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                      A                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                      +                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                      A                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                      +                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                      A                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                      +                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                      +                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                      +                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                      +                                                   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Islets,       |                                                                          |             
          Pancreatic                       |                                                                          |             
      Hepatocellular Adenoma               |                         X                    X                 X        X|             
      Hepatocellular Adenoma, Multiple     | X        X                                                               |             
      Lymphoma Malignant Histiocytic       |                      X                                                   |             
      Lymphoma Malignant Lymphocytic       |                                     X                    X               |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                      +            |             
      Lymphoma Malignant Histiocytic       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                |                      +                                                   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                      +                                                   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |                      +                          +                        |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                      +                                                   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                      +                                                   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                      +                                                   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                      +                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                      +                                                   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                      +                                                   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Pheochromocytoma Malignant           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 2| 3| 2| 3| 2| 2| 2| 2| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 2|             
                                           | 8| 0| 9| 2| 9| 0| 9| 5| 8| 9| 0| 8| 0| 0| 0| 2| 0| 9| 0| 1| 2| 1| 0| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                      +                                                   |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                      +                                                   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +              +                                                   |             
      Pars Distalis, Adenoma               |    X  X                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +                 +  +  +     +  +                          +     +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +        +  +  +  +     +  +  +  +     +  +  +     +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
      Polyp                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                      +                                                   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +                 +              +        +                           |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                     X                                    |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                      X                                                   |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +                 +              +                                    |             
      Lymphoma Malignant Histiocytic       |                      X                                                   |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +                 M              +                                    |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 2| 3| 2| 3| 2| 2| 2| 2| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 2|             
                                           | 8| 0| 9| 2| 9| 0| 9| 5| 8| 9| 0| 8| 0| 0| 0| 2| 0| 9| 0| 1| 2| 1| 0| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hemangiosarcoma                      |                                     X                                    |             
      Lymphoma Malignant Lymphocytic       |                                     X                    X               |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                      M                                                   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                      +                                                   |             
                                            __________________________________________________________________________|             
   Skin                                    |          +           +           +              +                        |             
      Subcutaneous Tissue, Fibrosarcoma    |          X                                      X                        |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Lymphocytic            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                      +                                      +            |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Carcinoma, Metastatic, Islets,       |                                                                          |             
          Pancreatic                       |                                                                          |             
      Lymphoma Malignant Histiocytic       |                      X                                                   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Gland        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                      +                                                   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +        +                                                   |             
      Adenoma                              |             X                                                            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                      +                       +                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 2| 3| 2| 3| 2| 2| 2| 2| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 2|             
                                           | 8| 0| 9| 2| 9| 0| 9| 5| 8| 9| 0| 8| 0| 0| 0| 2| 0| 9| 0| 1| 2| 1| 0| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                      X                                                   |             
      Lymphoma Malignant Lymphocytic       |                                     X                    X               |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 2| 7| 2| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 3|            |
                                           | 9| 1| 2| 2| 0| 8| 9| 2| 1| 9| 1| 8| 9| 9| 0| 8| 2| 2| 7| 1| 0| 1| 2| 2| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    10 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +                 +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |       +              +  M                                                |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +                 +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +                 +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +                 +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +                 +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +                 +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +                 +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +                 M                                                |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +                 A                                                |   2        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma, Metastatic, Islets,       |                                                                          |            |
          Pancreatic                       |                      X                                                   |          1 |
      Hepatocellular Adenoma               |                                           X        X                     |          6 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          2 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                     +                                    |   3        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +              +  +           +                                    |   5        |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +                 +                                                |   3        |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +                 +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +                 +                                                |   3        |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +                 +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |       +                 +                                                |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +                 +                                                |   3        |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |       +                 +                                      +         |   4        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  30                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 2| 7| 2| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 3|            |
                                           | 9| 1| 2| 2| 0| 8| 9| 2| 1| 9| 1| 8| 9| 9| 0| 8| 2| 2| 7| 1| 0| 1| 2| 2| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    10 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |       +                 +                                      +         |   4        |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +                 +                                      +         |   4        |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          1 |
      Pheochromocytoma Malignant           |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +              +  +                                                |   4        |
      Carcinoma                            |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +                 +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +        +        +                                                |   6        |
      Pars Distalis, Adenoma               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +                 +                                                |   3        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +        +     +  +              +                                +|  17        |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  42        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Polyp                                |                                  X                                       |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |       +                 +                                                |   2        |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +                 +                                                |   3        |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +              M  +                             +                  |   7        |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |       X                                                                  |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Undifferentiated Cell Type       |                         X                                                |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  31                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 2| 7| 2| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 3|            |
                                           | 9| 1| 2| 2| 0| 8| 9| 2| 1| 9| 1| 8| 9| 9| 0| 8| 2| 2| 7| 1| 0| 1| 2| 2| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    10 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Lymphocytic                      |       X                                                                  |          1 |
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +                 +                             M                  |   5        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +              M  M                             +                  |   4        |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       M                 +                                                |   1        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       +                 +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +                 +                             +                  |   7        |
      Subcutaneous Tissue, Fibrosarcoma    |                                                       X                  |          3 |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant Lymphocytic            |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +                 +                                                |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +                 +                                                |   3        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +              +  +                          +           +         |   7        |
      Alveolar/Bronchiolar Adenoma         |                                                    X                     |          1 |
      Carcinoma, Metastatic, Islets,       |                                                                          |            |
          Pancreatic                       |                      X                                                   |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  32                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 2| 7| 2| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 3|            |
                                           | 9| 1| 2| 2| 0| 8| 9| 2| 1| 9| 1| 8| 9| 9| 0| 8| 2| 2| 7| 1| 0| 1| 2| 2| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    10 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
          Cell Type                        |                         X                                                |          1 |
      Pheochromocytoma Malignant,          |                                                                          |            |
          Metastatic, Adrenal Gland        |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |       +                 +                                                |   3        |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +                 +                                                |   3        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       +                 M                                                |   3        |
      Adenoma                              |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +                 +                                                |   4        |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +                 +                                                |   3        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                         X                                                |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  33                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 7| 9| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 0| 9| 6| 2| 3| 3| 2|             
                                           | 2| 1| 1| 1| 0| 2| 6| 0| 0| 1| 0| 9| 2| 0| 2| 8| 1| 0| 2| 1| 7| 8| 1| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Lymphoma Malignant Histiocytic       |                X                                                         |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |       X                                                                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                              X                           |             
      Hepatocellular Carcinoma             |                         X                                                |             
      Hepatocellular Carcinoma, Multiple   |                                                                X         |             
      Hepatocellular Adenoma               |                                           X        X           X     X   |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Lymphoma Malignant Histiocytic       |                X  X                                                      |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                                         |             
      Lymphoma Malignant Histiocytic       |                X                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                X                                                         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                               X              X                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Lymphoma Malignant Histiocytic       |                   X                                                      |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 7| 9| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 0| 9| 6| 2| 3| 3| 2|             
                                           | 2| 1| 1| 1| 0| 2| 6| 0| 0| 1| 0| 9| 2| 0| 2| 8| 1| 0| 2| 1| 7| 8| 1| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Lymphoma Malignant Histiocytic       |                   X                                                      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  M  +  M  +  +  +  +  M  M  M  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  M  +  +  M  M  +  +  +  M  +  +  +  M  M  M|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                   X                                                      |             
      Follicular Cell, Adenoma             |                            X              X     X                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +     +                 +  +  +  +           +  +           +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Adenoma           |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                          +               |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                   X                                                      |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Femoral, Hemangiosarcoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                X  X                                                      |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Lymphoma Malignant Histiocytic       |                X                                                         |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             |       X                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  M  M  M  +  +  M  M  M  M  +  +  +  +  +  M  M  +  M  M  M  M  M|             
      Hemangiosarcoma                      |                                              X                           |             
      Lymphoma Malignant Histiocytic       |                   X                                                      |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             |       X                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                         X|             
      Lymphoma Malignant Histiocytic       |                X  X                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 7| 9| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 0| 9| 6| 2| 3| 3| 2|             
                                           | 2| 1| 1| 1| 0| 2| 6| 0| 0| 1| 0| 9| 2| 0| 2| 8| 1| 0| 2| 1| 7| 8| 1| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  M  M  I  +  M  +  M  M  +  M  +  +  M|             
      Lymphoma Malignant Histiocytic       |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibroma         |                                                 X                        |             
      Subcutaneous Tissue, Fibrosarcoma    |                                     X                 X  X  X            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                   X      |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                X         |             
      Lymphoma Malignant Histiocytic       |                   X                                                      |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                            +   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |             X                                                        X   |             
      Lymphoma Malignant Histiocytic       |                X  X                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                X  X                                                      |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                X  X                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 7| 9| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 0| 9| 6| 2| 3| 3| 2|             
                                           | 2| 1| 1| 1| 0| 2| 6| 0| 0| 1| 0| 9| 2| 0| 2| 8| 1| 0| 2| 1| 7| 8| 1| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 3| 3| 5| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2|            |
                                           | 8| 8| 8| 1| 2| 4| 2| 1| 0| 2| 0| 8| 2| 2| 1| 1| 0| 1| 0| 2| 1| 8| 1| 1| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Adenocarcinoma                       |                                                                   X      |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          1 |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Mixed                            | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                   X                                                      |          2 |
      Hepatocellular Carcinoma             |                   X                                                      |          2 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Hepatocellular Adenoma               |                                                    X  X                 X|          7 |
      Hepatocellular Adenoma, Multiple     |    X                                      X                              |          2 |
      Lymphoma Malignant Histiocytic       |                                                                X         |          3 |
      Lymphoma Malignant Mixed             |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Squamous Cell Papilloma              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  38                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 3| 3| 5| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2|            |
                                           | 8| 8| 8| 1| 2| 4| 2| 1| 0| 2| 0| 8| 2| 2| 1| 1| 0| 1| 0| 2| 1| 8| 1| 1| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  M  M  +  +  +  I  M  +  +  +|  36        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Follicular Cell, Adenoma             |                                                 X                        |          4 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                               +                             +            |   2        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +           +  +        +        +     +                              |  19        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Interstitial Cell, Adenoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +                                                                        |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                                                X         |          2 |
      Lymphoma Malignant Mixed             |                X                                                         |          1 |
      Femoral, Hemangiosarcoma             |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                                                                          |          2 |
      Mediastinal, Lymphoma Malignant Mixed|                X        X           X                                    |          3 |
      Pancreatic, Lymphoma Malignant Mixed | X                                                                        |          1 |
      Renal, Lymphoma Malignant Mixed      |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  39                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 3| 3| 5| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2|            |
                                           | 8| 8| 8| 1| 2| 4| 2| 1| 0| 2| 0| 8| 2| 2| 1| 1| 0| 1| 0| 2| 1| 8| 1| 1| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                X                    X                                    |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  M  +  +  M  M  M  M  +  M  +  M  +  +  M  +  +  +  +  M  +  +  M  M  M|  22        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                X         |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                         X           X                                    |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                   X                                                  X   |          3 |
      Lymphoma Malignant Histiocytic       |                                                                X         |          3 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                X        X           X                                    |          3 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  M  M|  36        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Subcutaneous Tissue, Fibroma         |                                        X              X                  |          3 |
      Subcutaneous Tissue, Fibrosarcoma    |                                        X           X                     |          6 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |       X                                                  X  X            |          4 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |             X                                                            |          1 |
      Alveolar/Bronchiolar Carcinoma       |          X                 X                                            X|          3 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                X         |          2 |
      Lymphoma Malignant Mixed             |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  40                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 3| 3| 5| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2|            |
                                           | 8| 8| 8| 1| 2| 4| 2| 1| 0| 2| 0| 8| 2| 2| 1| 1| 0| 1| 0| 2| 1| 8| 1| 1| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              | X           X                                                        X   |          5 |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                                                X         |          3 |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          2 |
      Lymphoma Malignant Mixed             | X              X        X           X                                    |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  41                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 2| 6| 7| 7|             
                             DAY ON TEST   | 2| 3| 7| 3| 3| 3| 2| 3| 3| 1| 2| 7| 3| 0| 3| 6| 3| 3| 3| 2| 2| 4| 7| 2| 3|             
                                           | 9| 1| 9| 2| 0| 3| 8| 2| 0| 4| 9| 4| 0| 8| 2| 7| 2| 1| 2| 8| 9| 6| 4| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +                                                        +         |             
                                            __________________________________________________________________________|             
   Gallbladder                             |       A                                                        A         |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +                                +                       +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       A                                                        A         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +                                +                       +         |             
      Cholangiocarcinoma, Metastatic, Liver|                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       A                                                        A         |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       A                                                        +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       A                                                        +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       A                                                        +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       A                                                        +         |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cholangiocarcinoma                   |                                        X                                 |             
      Hemangiosarcoma                      |                                                                          |             
      Hemangiosarcoma, Multiple            |       X                                                                  |             
      Hepatocellular Carcinoma             |    X                             X     X     X                    X      |             
      Hepatocellular Adenoma               |                      X     X              X  X     X     X               |             
      Hepatocellular Adenoma, Multiple     |          X                                                               |             
      Lymphoma Malignant Histiocytic       |                            X                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                |       A                                                        +         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +                                                        +         |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +                                                        +         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +                                                        +         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +                                                        +         |             
                                            __________________________________________________________________________|             
   Tooth                                   |       +                                                        +         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +                                                        +         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +                                                        +         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +                                                        +         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +                                                        +         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       A                                                        M         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +                                                        M         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +                                                        +         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +                                                        +         |             
      C-Cell, Adenoma                      |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 2| 6| 7| 7|             
                             DAY ON TEST   | 2| 3| 7| 3| 3| 3| 2| 3| 3| 1| 2| 7| 3| 0| 3| 6| 3| 3| 3| 2| 2| 4| 7| 2| 3|             
                                           | 9| 1| 9| 2| 0| 3| 8| 2| 0| 4| 9| 4| 0| 8| 2| 7| 2| 1| 2| 8| 9| 6| 4| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |       +                                                        +         |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                +  +      |             
                                            __________________________________________________________________________|             
   Prostate                                |       +                                                        +         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |       +                                                        +         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       A                                                        +         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +           +     +  +     +           +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +     +                                                  +         |             
      Melanoma Malignant, Metastatic, Skin |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +              +     +  +     +           +  +     +  M  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                              X                           |             
                                            __________________________________________________________________________|             
   Thymus                                  |       I                                                        M         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       M                                                        M         |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +     +  +     +        +        +           +  +  +  +      |             
      Subcutaneous Tissue, Fibroma         |                      X                                   X               |             
      Subcutaneous Tissue, Fibrosarcoma    |                                     X                       X            |             
      Subcutaneous Tissue, Melanoma        |                                                                          |             
          Malignant                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +           +  +        +        +  +        +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +                                                        +         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +                                               +        +         |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                       X                  |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Melanoma Malignant, Metastatic, Skin |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |       +                                                        +         |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +                                                        +         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 2| 6| 7| 7|             
                             DAY ON TEST   | 2| 3| 7| 3| 3| 3| 2| 3| 3| 1| 2| 7| 3| 0| 3| 6| 3| 3| 3| 2| 2| 4| 7| 2| 3|             
                                           | 9| 1| 9| 2| 0| 3| 8| 2| 0| 4| 9| 4| 0| 8| 2| 7| 2| 1| 2| 8| 9| 6| 4| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                            +           M        +|             
      Adenoma                              |                                                    X                    X|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +                                                        +         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     A     +                                               +  +         |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                            X                                             |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 2| 0| 2| 3| 0| 3| 3| 2| 2| 3| 7| 2| 3| 2| 6| 3| 2| 3| 2| 3| 3|            |
                                           | 8| 1| 0| 0| 9| 3| 9| 2| 3| 2| 1| 8| 9| 1| 5| 8| 1| 9| 7| 2| 8| 0| 9| 7| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    3 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                      +                    +                          +   |   5        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                      A                    A                          A   |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                      +                    +                          +   |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                      M                    +                          A   |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                      +                    +                          +   |   6        |
      Cholangiocarcinoma, Metastatic, Liver|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                      A                    +                          A   |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +                 +                    +                          A   |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                      I                    +                          A   |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                      M                    +                          A   |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +                 +                    +                          A   |   4        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Lymphocytic                      |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cholangiocarcinoma                   |                                                                          |          1 |
      Hemangiosarcoma                      |                                  X                                       |          1 |
      Hemangiosarcoma, Multiple            |                                                                          |          1 |
      Hepatocellular Carcinoma             |             X                                                        X   |          7 |
      Hepatocellular Adenoma               |                X     X              X                       X           X|         11 |
      Hepatocellular Adenoma, Multiple     |                                                 X     X        X         |          4 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                      +                    +                          A   |   3        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                      +                    +                          +   |   5        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                      +                    +                          +   |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                      +                    +                          +   |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                      +                    +                          +   |   5        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                      +                    +                          +   |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                      +                    +                          +   |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                      +                    +                          +   |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                      +                    +                          +   |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                      I                    +                          +   |   4        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                      +                    +                          A   |   2        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                      +                    +                          +   |   4        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                      +                    +                          M   |   4        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                      +                    +                          +   |   5        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  45                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 2| 0| 2| 3| 0| 3| 3| 2| 2| 3| 7| 2| 3| 2| 6| 3| 2| 3| 2| 3| 3|            |
                                           | 8| 1| 0| 0| 9| 3| 9| 2| 3| 2| 1| 8| 9| 1| 5| 8| 1| 9| 7| 2| 8| 0| 9| 7| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    3 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Adenoma                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                      +                    +                          +   |   5        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                     +                                    |   3        |
                                            __________________________________________________________________________|____________|
   Prostate                                |                      +                    +                          M   |   4        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  |                      +                    +                          +   |   5        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                      +                    +                          A   |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +           +     +  +        +  +  +  +        +  +              +   |  25        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                      +  +                 +                          +   |   8        |
      Melanoma Malignant, Metastatic, Skin |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +           +     M  +        +  +  +  M        +  +              M   |  19        |
      Lymphoma Malignant Lymphocytic       |    X                                                                     |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  47        |
      Hemangiosarcoma                      |                                              X                           |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                      M                    A                          M   |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                      M                    M                          M   |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +  +  +  +  +  +  +  M  +           +  +  +     +              +  +|  27        |
      Subcutaneous Tissue, Fibroma         |                               X                       X                  |          4 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                 X                        |          3 |
      Subcutaneous Tissue, Melanoma        |                                                                          |            |
          Malignant                        |                                                                      X   |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +  +  +     +  +                 +  +  +  +  +  +  +           +  +|  28        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                      +                    +                          +   |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  46                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 2| 0| 2| 3| 0| 3| 3| 2| 2| 3| 7| 2| 3| 2| 6| 3| 2| 3| 2| 3| 3|            |
                                           | 8| 1| 0| 0| 9| 3| 9| 2| 3| 2| 1| 8| 9| 1| 5| 8| 1| 9| 7| 2| 8| 0| 9| 7| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    3 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                      +           +        +  +              +        +  +|  10        |
      Alveolar/Bronchiolar Adenoma         |                                  X           X              X           X|          4 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                      X   |          1 |
      Melanoma Malignant, Metastatic, Skin |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                      +                    +                          +   |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                      +                    +                          +   |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                      +                    +                          M   |   5        |
      Adenoma                              |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                   +  +                    +                          +   |   6        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +              +  +     +           A                          A   |   8        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |    X                                                                     |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  47                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 9| 9| 3| 3| 2| 3| 3| 2| 2| 7| 3| 3| 2| 2| 2| 2| 2| 3| 2| 3| 2| 0| 3| 3|             
                                           | 1| 0| 9| 2| 0| 9| 1| 2| 9| 9| 4| 1| 1| 8| 8| 9| 9| 8| 2| 8| 2| 8| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |       X                                                                 X|             
      Hemangiosarcoma, Multiple            |                                        X                                 |             
      Hepatocellular Carcinoma             |          X                          X  X                 X        X      |             
      Hepatocellular Carcinoma, Multiple   |    X                                                                     |             
      Hepatocellular Adenoma               |             X  X                             X                           |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                         X|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                X                                                         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                          X               |             
      Serosa, Fibrosarcoma, Metastatic,    |                                                                          |             
           Skin                            |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Multiple, Metastatic,  |                                                                          |             
           Skin                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Adenoma                     |                                                             X            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 9| 9| 3| 3| 2| 3| 3| 2| 2| 7| 3| 3| 2| 2| 2| 2| 2| 3| 2| 3| 2| 0| 3| 3|             
                                           | 1| 0| 9| 2| 0| 9| 1| 2| 9| 9| 4| 1| 1| 8| 8| 9| 9| 8| 2| 8| 2| 8| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  M  M  +  I  M  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +     +                                +                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +                    +  +                                             |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                         X|             
      Femoral, Hemangiosarcoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                         X|             
      Lumbar, Lymphoma Malignant Mixed     |                                                                         X|             
      Mediastinal, Lymphoma Malignant Mixed|                                                                         X|             
      Pancreatic, Lymphoma Malignant Mixed |                                                                         X|             
      Renal, Lymphoma Malignant Mixed      |                                                                         X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                         X|             
      Mast Cell Tumor Benign               |                X                                                         |             
      Mediastinal, Fibrosarcoma,           |                                                                          |             
          Metastatic, Skin                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  +  +  +  M  M  +|             
      Lymphoma Malignant Mixed             |                                                                         X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                     X                                    |             
      Lymphoma Malignant Mixed             |                                                                         X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  M  +  +  +  +  +  +  M  +  M  M  +  +  M  M  +  I  +  M  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basosquamous Tumor Benign            |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 9| 9| 3| 3| 2| 3| 3| 2| 2| 7| 3| 3| 2| 2| 2| 2| 2| 3| 2| 3| 2| 0| 3| 3|             
                                           | 1| 0| 9| 2| 0| 9| 1| 2| 9| 9| 4| 1| 1| 8| 8| 9| 9| 8| 2| 8| 2| 8| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                           X                              |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                               +           +                              |             
      Intercostal, Fibrosarcoma,           |                                                                          |             
          Metastatic, Skin                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                            X                 X                           |             
      Alveolar/Bronchiolar Carcinoma       |                                  X                    X                  |             
      Fibrosarcoma, Multiple, Metastatic,  |                                                                          |             
           Skin                            |                                                                          |             
      Hemangiosarcoma, Metastatic, Liver   |                                        X                                 |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                        X                 X               |             
      Lymphoma Malignant Mixed             |                                                                         X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                                     +                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | M  +  M  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  M  M  M  +  +  +|             
      Adenoma                              |                      X                             X  X                  |             
      Adenoma, Multiple                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                         X|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 6| 2| 2| 3| 3| 2| 2| 2| 0| 2| 9| 3| 8| 3| 2| 3| 8| 8| 3| 2| 8| 3| 2|            |
                                           | 8| 2| 7| 5| 8| 2| 0| 8| 4| 9| 2| 9| 0| 1| 2| 0| 2| 2| 8| 2| 2| 9| 2| 0| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    30 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  A  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                                   X      |          3 |
      Hemangiosarcoma, Multiple            |                                                 X           X            |          3 |
      Hepatocellular Carcinoma             |    X     X  X     X              X              X     X           X      |         13 |
      Hepatocellular Carcinoma, Multiple   |                               X        X                 X               |          4 |
      Hepatocellular Adenoma               |                                                                          |          3 |
      Hepatocellular Adenoma, Multiple     |                                                             X            |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Lymphoma Malignant Mixed             |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Adenocarcinoma                       |                                                                          |          1 |
      Serosa, Fibrosarcoma, Metastatic,    |                                                                          |            |
           Skin                            |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosarcoma, Multiple, Metastatic,  |                                                                          |            |
           Skin                            |                                     X                                    |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  51                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 6| 2| 2| 3| 3| 2| 2| 2| 0| 2| 9| 3| 8| 3| 2| 3| 8| 8| 3| 2| 8| 3| 2|            |
                                           | 8| 2| 7| 5| 8| 2| 0| 8| 4| 9| 2| 9| 0| 1| 2| 0| 2| 2| 8| 2| 2| 9| 2| 0| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    30 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Capsule, Adenoma                     |                                                             X            |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosarcoma, Metastatic, Skin       |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  M  +  M  M  M  +  +  +  +  M|  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | I  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Follicular Cell, Adenoma             |                   X              X                                      X|          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Mixed             |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +              +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Femoral, Hemangiosarcoma             |                                                 X           X            |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          1 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Lymphoma Malignant Mixed             |                                                                X         |          2 |
      Mast Cell Tumor Benign               |                                                                          |          1 |
      Mediastinal, Fibrosarcoma,           |                                                                          |            |
          Metastatic, Skin                 |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  +  M  M  M  M  +  M  M  +  M  +  M  +  +  M  +  M  +  M  +  M  +  M  M|  17        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  52                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 6| 2| 2| 3| 3| 2| 2| 2| 0| 2| 9| 3| 8| 3| 2| 3| 8| 8| 3| 2| 8| 3| 2|            |
                                           | 8| 2| 7| 5| 8| 2| 0| 8| 4| 9| 2| 9| 0| 1| 2| 0| 2| 2| 8| 2| 2| 9| 2| 0| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    30 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemangiosarcoma                      |             X                                   X        X  X            |          5 |
      Lymphoma Malignant Mixed             |                                                                X         |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  M  M  +  M  +  +  +  +  +  I  M  M  M  +  M  +  M  M  I  +  M  +  +|  27        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basosquamous Tumor Benign            |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |          X                          X     X                              |          4 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                     +                                    |   3        |
      Intercostal, Fibrosarcoma,           |                                                                          |            |
          Metastatic, Skin                 |                                     X                                    |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |          X                                               X               |          4 |
      Alveolar/Bronchiolar Carcinoma       |          X                                                               |          3 |
      Fibrosarcoma, Multiple, Metastatic,  |                                                                          |            |
           Skin                            |                                     X                                    |          1 |
      Hemangiosarcoma, Metastatic, Liver   |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |             X     X           X        X        X        X        X      |          9 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                                                      |   3        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  +  +|  40        |
      Adenoma                              | X                                                                        |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  53                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 6| 2| 2| 3| 3| 2| 2| 2| 0| 2| 9| 3| 8| 3| 2| 3| 8| 8| 3| 2| 8| 3| 2|            |
                                           | 8| 2| 7| 5| 8| 2| 0| 8| 4| 9| 2| 9| 0| 1| 2| 0| 2| 2| 8| 2| 2| 9| 2| 0| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    30 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Adenoma, Multiple                    |                                     X                                    |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Mixed             |                                                                X         |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                                          X     X         |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  54                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 6| 7| 7| 4| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 8| 3| 5| 2| 2| 4| 2| 6| 2| 2| 6| 8| 3| 3| 2| 3| 3| 8| 3| 1| 3| 3| 3| 3|             
                                           | 9| 9| 0| 5| 8| 8| 3| 9| 6| 6| 8| 7| 7| 1| 0| 9| 2| 0| 4| 2| 4| 1| 2| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +              +        +                          +     M            |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    A              A        +                          +     A  +         |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +              +        +                          +     +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +              A        +                          +     A            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +              +        +                          +     +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +              A        +                          +     +            |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +              +        +     +                    +     +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +              A        +                          +     +            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +              A        +                          +     M            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +              +        +     +                    +     +            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                                  X                                       |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             |                            X                                X  X         |             
      Hepatocellular Carcinoma, Multiple   |          X                          X                                    |             
      Hepatocellular Adenoma               |       X           X                                      X  X     X      |             
      Hepatocellular Adenoma, Multiple     |                                           X        X                     |             
      Hepatocholangiocarcinoma             |                                                       X                  |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +              +        +                          +     +            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +              +        +                          +     +            |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +              +        +                          +     +            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +              +        +                          +     +            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +              +        +                          +     +            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +              +        +                          +     +            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +              +        +                          +     +            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Epicardium, Sarcoma                  |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +              +        +                          +     +            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +              +        +                          +     +            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +              +        +                          +     +            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 6| 7| 7| 4| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 8| 3| 5| 2| 2| 4| 2| 6| 2| 2| 6| 8| 3| 3| 2| 3| 3| 8| 3| 1| 3| 3| 3| 3|             
                                           | 9| 9| 0| 5| 8| 8| 3| 9| 6| 6| 8| 7| 7| 1| 0| 9| 2| 0| 4| 2| 4| 1| 2| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +              +        +                          +     +            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M              M        M                          M     +            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    I              M        +                          M     +            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +              +        +                          +     +            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +              +        +                          +     +            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +           +                                            +  +|             
                                            __________________________________________________________________________|             
   Prostate                                |    +              +        +                          +     +            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |    +              +        +                          +     +            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +                                                                     |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +              +        +                          +     +            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +              +  +  +  +  +  +           +     +  +     +  +  +     +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +              +        +                 +        +     +            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    M              M  +  +  M  +  +           +     +  M     M  +  +     +|             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  |    M              M        M                          +     +            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 6| 7| 7| 4| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 8| 3| 5| 2| 2| 4| 2| 6| 2| 2| 6| 8| 3| 3| 2| 3| 3| 8| 3| 1| 3| 3| 3| 3|             
                                           | 9| 9| 0| 5| 8| 8| 3| 9| 6| 6| 8| 7| 7| 1| 0| 9| 2| 0| 4| 2| 4| 1| 2| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M              M        M                          M     M            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +  +  M  +     +           +  +     +     +      |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |             X                          X                                 |             
      Subcutaneous Tissue, Fibrosarcoma    |    X              X     X        X                                X      |             
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |             
           Multiple                        |                                                                          |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Lymphocytic            |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +     +  +  +  +  +  +              +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +              +        +                          +     +            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +     +        +     +  +                          +     +     +      |             
      Alveolar/Bronchiolar Adenoma         |                   X     X                                         X      |             
      Alveolar/Bronchiolar Carcinoma       |                         X                                                |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |          X                 X                                             |             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                       X                  |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Mediastinum, Sarcoma                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Nose                                    |    +              +        +                          +     +            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +              +        +                          +     +            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                                             |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    M              +        +                          M  +  +            |             
      Adenoma                              |                                                          X               |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +              +        +     +                    +     +            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +              +  +     +                          +     +            |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 6| 7| 7| 4| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 8| 3| 5| 2| 2| 4| 2| 6| 2| 2| 6| 8| 3| 3| 2| 3| 3| 8| 3| 1| 3| 3| 3| 3|             
                                           | 9| 9| 0| 5| 8| 8| 3| 9| 6| 6| 8| 7| 7| 1| 0| 9| 2| 0| 4| 2| 4| 1| 2| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                      X           X                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 7| 6| 7| 6| 6|            |
                             DAY ON TEST   | 2| 3| 2| 6| 2| 1| 0| 3| 6| 0| 2| 3| 3| 7| 3| 2| 2| 7| 2| 2| 2| 8| 2| 6| 6|            |
                                           | 9| 1| 9| 7| 8| 1| 3| 1| 7| 3| 4| 0| 2| 4| 0| 3| 9| 4| 9| 9| 9| 7| 9| 7| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    10 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                +                             +                           |   6        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                +                             A                           |   4        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                +                             +                           |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                +                             A                           |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                +                             +                           |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                +                             A                           |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                +                             +                       +   |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                +                             +                           |   6        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                M                             A                           |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                +                             A                       +   |   8        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Lymphocytic                      |                                                                      X   |          2 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                       X                  |          1 |
      Hepatocellular Carcinoma             |                               X        X           X                 X  X|          8 |
      Hepatocellular Carcinoma, Multiple   |          X                                                               |          3 |
      Hepatocellular Adenoma               |             X           X                                X               |          8 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          2 |
      Hepatocholangiocarcinoma             |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                   X                                                      |          1 |
      Lymphoma Malignant Lymphocytic       |             X  X                             X                           |          3 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                +                             +                           |   7        |
      Lymphoma Malignant Lymphocytic       |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                +                             +                           |   7        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                +                             +                           |   7        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                +                             +                           |   7        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                +                             +                           |   7        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                +                             +                           |   7        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                +  +                          +                           |   8        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
      Epicardium, Sarcoma                  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  59                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 7| 6| 7| 6| 6|            |
                             DAY ON TEST   | 2| 3| 2| 6| 2| 1| 0| 3| 6| 0| 2| 3| 3| 7| 3| 2| 2| 7| 2| 2| 2| 8| 2| 6| 6|            |
                                           | 9| 1| 9| 7| 8| 1| 3| 1| 7| 3| 4| 0| 2| 4| 0| 3| 9| 4| 9| 9| 9| 7| 9| 7| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    10 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                +                             +                           |   7        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                +                             +                           |   7        |
      Lymphoma Malignant Lymphocytic       |                X                             X                           |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                +                             +                           |   7        |
      Lymphoma Malignant Lymphocytic       |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                M                             +                           |   6        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                M                             M                           |   1        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                +                             +                           |   4        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                +                             +                           |   7        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                +                             +                           |   7        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Penis                                   |                   +        +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                      +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Prostate                                |                +                             +                           |   7        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                               +                                +         |   2        |
                                            __________________________________________________________________________|____________|
   Testes                                  |                +                             +                           |   7        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                +                                                         |   2        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                +                             +                           |   7        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +  +  +  +  +     +     +     +     +           +        +  +  +|  28        |
      Lymphoma Malignant Histiocytic       |                   X                                                      |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                X                             X                           |          2 |
      Renal, Lymphoma Malignant Lymphocytic|                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |             +  +                             +                           |   9        |
      Lymphoma Malignant Lymphocytic       |             X  X                             X                           |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +  +     +     +     +     +     +     M           +        +  +  +|  20        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  60                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 7| 6| 7| 6| 6|            |
                             DAY ON TEST   | 2| 3| 2| 6| 2| 1| 0| 3| 6| 0| 2| 3| 3| 7| 3| 2| 2| 7| 2| 2| 2| 8| 2| 6| 6|            |
                                           | 9| 1| 9| 7| 8| 1| 3| 1| 7| 3| 4| 0| 2| 4| 0| 3| 9| 4| 9| 9| 9| 7| 9| 7| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    10 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       |       X        X     X                                               X   |          5 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                   X                                                      |          1 |
      Lymphoma Malignant Lymphocytic       |       X     X  X                             X                           |          5 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                +                             M                           |   3        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                M                             M                           |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |          +     +     +  +  +                 +  +  +     +  +     +  +  +|  28        |
      Squamous Cell Papilloma              |                                                 X                        |          1 |
      Subcutaneous Tissue, Fibroma         |                      X                             X     X               |          5 |
      Subcutaneous Tissue, Fibrosarcoma    |          X              X                                X               |          8 |
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |            |
           Multiple                        |                            X                                             |          1 |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant Lymphocytic            |                X                                                         |          1 |
      Subcutaneous Tissue, Sarcoma         |                                                                         X|          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +        +           +           +     +        +  +  +     +      |  26        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                +                             +                           |   7        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                +     +     +  +              +        +                  |  14        |
      Alveolar/Bronchiolar Adenoma         |                      X     X                                             |          5 |
      Alveolar/Bronchiolar Carcinoma       |                               X                       X                  |          3 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          2 |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                X                             X                           |          2 |
      Mediastinum, Sarcoma                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                +                             +                           |   7        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  61                                                               
NTP Experiment-Test: 05020-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 7| 6| 7| 6| 6|            |
                             DAY ON TEST   | 2| 3| 2| 6| 2| 1| 0| 3| 6| 0| 2| 3| 3| 7| 3| 2| 2| 7| 2| 2| 2| 8| 2| 6| 6|            |
                                           | 9| 1| 9| 7| 8| 1| 3| 1| 7| 3| 4| 0| 2| 4| 0| 3| 9| 4| 9| 9| 9| 7| 9| 7| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    10 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                +                             +                           |   7        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                             +     +                     |   7        |
      Adenoma                              |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                +                             +  +                       +|  10        |
      Lymphoma Malignant Lymphocytic       |                X                             X                           |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                +              +              +           +     +         |  11        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                   X                                                      |          1 |
      Lymphoma Malignant Lymphocytic       |       X     X  X     X                       X                       X   |          8 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  62                                                               
                                  ------------------------------------------------------------                                      
                                  ----------              END OF REPORT             ----------                                      
                                  ------------------------------------------------------------