TR 351 Mouse Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
PARA-CHLOROANILINE
NTP Experiment-Test: 05020-02 Report: PEIRPT05
Study Type: CHRONIC Date: 09/03/94
Route: GAVAGE Time: 19:58:22
Facility: Battelle Columbus Laboratory
Chemical CAS #: 106-47-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05020-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 19:58:22
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund 5 4 3 4
Dead 5 1 3 5
Dosing Accident 1 3
Survivors
Terminal Sacrifice 39 42 44 41
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (47) (3) (2) (46)
Intestine Small, Jejunum (46) (4) (2) (48)
Liver (50) (50) (50) (50)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%)
Hemangiosarcoma 1 (2%) 1 (2%)
Hepatocellular Carcinoma 1 (2%) 2 (4%) 3 (6%)
Hepatocellular Carcinoma, Multiple 2 (4%)
Hepatocellular Adenoma 5 (10%) 6 (12%) 6 (12%) 8 (16%)
Hepatocellular Adenoma, Multiple 1 (2%) 2 (4%)
Mesentery (2) (2) (3) (3)
Pancreas (48) (7) (5) (49)
Salivary Glands (47) (5) (3) (48)
Stomach, Forestomach (48) (5) (3) (46)
Squamous Cell Papilloma 1 (2%) 1 (20%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (5) (3) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (5) (4) (49)
Capsule, Adenoma 2 (4%)
Adrenal Gland, Cortex (50) (5) (4) (49)
Adrenal Gland, Medulla (50) (5) (4) (49)
Pheochromocytoma Malignant 1 (25%)
Pheochromocytoma Benign 2 (4%)
Islets, Pancreatic (48) (5) (4) (49)
Carcinoma 1 (25%)
Pituitary Gland (46) (5) (6) (42)
Page 2
NTP Experiment-Test: 05020-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 19:58:22
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pars Distalis, Adenoma 3 (7%) 1 (20%) 2 (33%) 3 (7%)
Thyroid Gland (49) (4) (3) (49)
Follicular Cell, Adenoma 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (50) (14) (17) (47)
Cystadenoma 1 (2%) 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Granulosa Cell Tumor Benign 1 (2%)
Follicle, Adenoma 1 (2%)
Uterus (50) (38) (42) (48)
Hemangioma 1 (2%)
Polyp 1 (2%)
Polyp Stromal 1 (2%) 1 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (1) (2) (3)
Bone Marrow (48) (5) (3) (49)
Lymph Node (48) (5) (7) (47)
Mediastinal, Fibrosarcoma, Metastatic, Skin 1 (2%)
Renal, Fibrosarcoma, Metastatic, Skin 1 (2%)
Lymph Node, Mandibular (46) (5) (5) (47)
Lymph Node, Mesenteric (8) (4) (3)
Spleen (50) (50) (50) (49)
Hemangiosarcoma 1 (2%) 1 (2%) 1 (2%)
Thymus (41) (4) (1) (35)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (38) (5) (3) (44)
Adenocarcinoma 1 (20%)
Adenoma 1 (20%)
Skin (50) (7) (7) (49)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 3 (43%) 3 (6%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05020-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 19:58:22
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (6) (3) (50)
Cranium, Osteoma 1 (17%)
Sacrum, Osteosarcoma 1 (2%)
Skeletal Muscle (1) (1)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (48) (5) (3) (49)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (8) (7) (50)
Alveolar/Bronchiolar Adenoma 5 (10%) 2 (25%) 1 (14%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (13%) 2 (4%)
Carcinoma, Metastatic, Islets, Pancreatic 1 (14%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (13%) 2 (4%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Gland 1 (14%)
Mediastinum, Fibrosarcoma, Metastatic, Skin 1 (2%)
Nose (50) (5) (3) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (48) (4) (3) (47)
Adenoma 3 (6%) 1 (25%) 1 (33%) 4 (9%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (7) (4) (49)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (48) (5) (3) (44)
Fibrosarcoma, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Lymphoma Malignant Histiocytic 3 (6%) 3 (6%) 1 (2%) 2 (4%)
Lymphoma Malignant Lymphocytic 10 (20%) 8 (16%) 3 (6%) 5 (10%)
Lymphoma Malignant Mixed 6 (12%) 1 (2%) 3 (6%)
Lymphoma Malignant Undifferentiated Cell 1 (2%) 1 (2%)
* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 05020-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 19:58:22
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(50) *(50) *(50) *(50)
____________________________________________________________________________________________________________________________________
Page 5
NTP Experiment-Test: 05020-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 19:58:22
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 36 26 21 31
Total Primary Neoplasms 54 32 24 44
Total Animals with Benign Neoplasms 20 15 12 17
Total Benign Neoplasms 29 15 13 22
Total Animals with Malignant Neoplasms 24 16 10 21
Total Malignant Neoplasms 25 17 11 22
Total Animals with Metastatic Neoplasms 1 1 2 4
Total Metastatic Neoplasm 3 1 3 5
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05020-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 19:58:22
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund 3 6 12 9
Dead 4 7 9 6
Survivors
Terminal Sacrifice 43 36 29 35
Missing 1
Animals Examined Microscopically 50 49 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (45) (4) (47)
Intestine Large, Colon (48) (6) (7) (48)
Cholangiocarcinoma, Metastatic, Liver 1 (17%)
Intestine Small, Duodenum (48) (2) (6) (45)
Intestine Small, Jejunum (47) (4) (8) (47)
Adenocarcinoma 1 (2%)
Liver (50) (49) (50) (50)
Cholangiocarcinoma 1 (2%)
Hemangiosarcoma 2 (4%) 1 (2%) 1 (2%) 3 (6%)
Hemangiosarcoma, Multiple 1 (2%) 3 (6%)
Hepatocellular Carcinoma 2 (4%) 7 (14%) 8 (16%) 13 (26%)
Hepatocellular Carcinoma, Multiple 1 (2%) 3 (6%) 4 (8%)
Hepatocellular Adenoma 7 (14%) 11 (22%) 8 (16%) 3 (6%)
Hepatocellular Adenoma, Multiple 2 (4%) 4 (8%) 2 (4%) 1 (2%)
Hepatocholangiocarcinoma 1 (2%)
Mesentery (1)
Pancreas (49) (3) (7) (49)
Hemangiosarcoma 1 (2%)
Salivary Glands (50) (5) (7) (49)
Stomach, Forestomach (49) (5) (7) (48)
Squamous Cell Papilloma 2 (4%)
Stomach, Glandular (50) (5) (7) (48)
Adenocarcinoma 1 (2%)
Serosa, Fibrosarcoma, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (5) (8) (50)
Fibrosarcoma, Multiple, Metastatic, Skin 1 (2%)
Epicardium, Sarcoma 1 (13%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05020-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 19:58:22
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (49) (5) (7) (50)
Capsule, Adenoma 2 (4%)
Adrenal Gland, Cortex (49) (5) (7) (50)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Adrenal Gland, Medulla (49) (4) (7) (50)
Pituitary Gland (40) (4) (4) (41)
Thyroid Gland (50) (5) (7) (48)
C-Cell, Adenoma 1 (20%)
Follicular Cell, Adenoma 4 (8%) 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (5) (7) (49)
Prostate (48) (4) (7) (50)
Testes (49) (5) (7) (50)
Interstitial Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (2) (2)
Bone Marrow (50) (3) (7) (50)
Femoral, Hemangiosarcoma 1 (2%) 2 (4%)
Lymph Node (49) (25) (28) (49)
Lymph Node, Mandibular (48) (8) (9) (49)
Mast Cell Tumor Benign 1 (2%)
Melanoma Malignant, Metastatic, Skin 1 (13%)
Mediastinal, Fibrosarcoma, Metastatic, Skin 1 (2%)
Lymph Node, Mesenteric (22) (19) (20) (17)
Hemangiosarcoma 1 (5%)
Spleen (50) (47) (49) (49)
Hemangiosarcoma 3 (6%) 2 (4%) 5 (10%)
Thymus (36) (3) (27)
Sarcoma, Metastatic, Uncertain Primary Site 1 (33%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05020-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 19:58:22
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (49) (27) (28) (49)
Basosquamous Tumor Benign 1 (2%)
Squamous Cell Papilloma 1 (4%)
Subcutaneous Tissue, Fibroma 3 (6%) 4 (15%) 5 (18%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 6 (12%) 3 (11%) 8 (29%) 4 (8%)
Subcutaneous Tissue, Fibrosarcoma, Multiple 1 (4%)
Subcutaneous Tissue, Melanoma Malignant 1 (4%)
Subcutaneous Tissue, Sarcoma 1 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (3)
Intercostal, Fibrosarcoma, Metastatic, Skin 1 (33%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (5) (7) (50)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (10) (14) (50)
Alveolar/Bronchiolar Adenoma 4 (8%) 4 (40%) 5 (36%) 4 (8%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 3 (6%) 1 (10%) 3 (21%) 3 (6%)
Fibrosarcoma, Multiple, Metastatic, Skin 1 (2%)
Hemangiosarcoma, Metastatic, Liver 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) 1 (10%) 2 (14%) 9 (18%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (7%)
Melanoma Malignant, Metastatic, Skin 1 (10%)
Mediastinum, Sarcoma 1 (7%)
Nose (50) (5) (7) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (50) (5) (7) (40)
Adenoma 5 (10%) 2 (40%) 1 (14%) 4 (10%)
Adenoma, Multiple 1 (3%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05020-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 19:58:22
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (6) (10) (49)
Urinary Bladder (49) (8) (11) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(49) *(50) *(50)
Lymphoma Malignant Histiocytic 3 (6%) 1 (2%) 1 (2%)
Lymphoma Malignant Lymphocytic 2 (4%) 2 (4%) 8 (16%)
Lymphoma Malignant Mixed 5 (10%) 3 (6%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05020-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 19:58:22
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 40 30 35 36
Total Primary Neoplasms 59 46 59 63
Total Animals with Benign Neoplasms 23 20 17 18
Total Benign Neoplasms 29 26 22 21
Total Animals with Malignant Neoplasms 25 16 28 27
Total Malignant Neoplasms 30 20 37 42
Total Animals with Metastatic Neoplasms 1 2 3 10
Total Metastatic Neoplasm 1 4 4 16
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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