TR 351 Mouse Pathology Tables
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
Facility: Battelle Columbus Laboratory
Chemical CAS #: 106-47-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 2| 2| 3| 2| 2| 3| 2| 3| 2| 2| 2| 3| 2| 6| 8| 1| 3| 2|
| 3| 8| 8| 7| 9| 1| 0| 9| 8| 0| 8| 8| 2| 8| 1| 9| 8| 8| 0| 9| 6| 0| 7| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + A A + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + A A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + A A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A A + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A A + + +|
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + + + + + + A A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + A A + + +|
Inflammation, Chronic, Focal | |
Ulcer, Chronic, Focal | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + A A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + A A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Basophilic Focus | X |
Clear Cell Focus | |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 2 2 2 2 2 1 2 2 |
Necrosis, Acute, Multifocal | 2 |
Hepatocyte, Karyomegaly, Focal | 2|
Periportal, Inflammation, Multifocal | 2 |
Sinusoid, Infiltration Cellular, | |
Diffuse, Polymorphonuclear | 3 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + A + + +|
Acinus, Atrophy, Diffuse | |
Acinus, Atrophy, Focal | 2 |
Acinus, Atrophy, Multifocal | |
Duct, Cyst, Multiple | |
Duct, Inflammation, Chronic, | |
Multifocal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + A A + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + A A + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A A + + +|
Necrosis, Acute, Focal | 2 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 2| 2| 3| 2| 2| 3| 2| 3| 2| 2| 2| 3| 2| 6| 8| 1| 3| 2|
| 3| 8| 8| 7| 9| 1| 0| 9| 8| 0| 8| 8| 2| 8| 1| 9| 8| 8| 0| 9| 6| 0| 7| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Capsule, Cyst | |
Capsule, Hyperplasia, Cystic, | |
Glandular, Multifocal | |
Capsule, Hyperplasia, Multifocal | 3 3 2 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 3 2 3|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Hyperplasia, Focal | 2 |
Hyperplasia, Multifocal | |
Hypertrophy, Focal | 2 |
Hypertrophy, Multifocal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M M + + + + + M + M + M + + M + + M M M + +|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + M +|
Pars Distalis, Cyst | X X |
Pars Distalis, Cyst, Multiple | |
Pars Distalis, Hyperplasia, Focal | 2 2 |
Pars Distalis, Hyperplasia, | |
Multifocal | 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Necrosis, Acute, Focal | |
Follicular Cell, Hyperplasia, Focal | 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Multifocal | |
Thrombosis, Chronic Active | |
Follicle, Cyst | X X X X X X X |
Follicle, Cyst, Multiple | |
Periovarian Tissue, Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Angiectasis, Multifocal | 3 |
Endometrium, Hyperplasia, Cystic, | |
Glandular, Multifocal | 3 2 3 3 2 3 3 4 2 3 3 3 2 3 3 3 3 4 4 2 4 3 3|
Myometrium, Angiectasis, Multifocal | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Angiectasis, Focal | 3 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 2| 2| 3| 2| 2| 3| 2| 3| 2| 2| 2| 3| 2| 6| 8| 1| 3| 2|
| 3| 8| 8| 7| 9| 1| 0| 9| 8| 0| 8| 8| 2| 8| 1| 9| 8| 8| 0| 9| 6| 0| 7| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Femoral, Myelofibrosis, Multifocal | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + M M M M M M M M M + M M M M M M M M M + M + M M|
Lymphatic, Ectasia, Focal | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Follicle, Necrosis, Acute, | |
Multifocal | |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 1 1 2 3 1 1 1 1 2 1 2 2 1 1 2 2 1 1 1 2 3 3 3 1 1|
Red Pulp, Pigmentation, Hemosiderin, | |
Multifocal | 2 1 2 1 1 2 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Thymus | + + M M + + + + + M M + + + + + + + + + + + + + +|
Necrosis, Acute, Multifocal | |
Medulla, Thymocyte, Hyperplasia, | |
Diffuse | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + + + + + + M + + + + + + + + + + + M + + M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite External | X X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Joint, Tarsal, | |
Hyperostosis | 2 |
Bilateral, Joint, Tarsal, Metaplasia,| |
Multifocal, Osseous | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Multifocal | 2 |
Meninges, Infiltration Cellular, | |
Multifocal, Lymphocyte | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitium, Inflammation, Chronic, | |
Multifocal | 2 2 |
Interstitium, Inflammation, Chronic | |
Active, Multifocal | |
Mediastinum, Foreign Body, Multifocal| |
Perivascular, Hyperplasia, Lymphoid, | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 2| 2| 3| 2| 2| 3| 2| 3| 2| 2| 2| 3| 2| 6| 8| 1| 3| 2|
| 3| 8| 8| 7| 9| 1| 0| 9| 8| 0| 8| 8| 2| 8| 1| 9| 8| 8| 0| 9| 6| 0| 7| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Multifocal | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Inflammation, Chronic Active, Diffuse| 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic, Diffuse | |
Nephropathy, Chronic, Focal | 3 2 2 |
Nephropathy, Chronic, Multifocal | |
Glomerulus, Amyloid Deposition, | |
Multifocal | |
Renal Tubule, Regeneration, Focal | |
Renal Tubule, Regeneration, | |
Multifocal | 2 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + A + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 1| 3| 3| 0| 3| 2| 3| 7| 3| 2| 9| 9| 2| 3| 3| 2| 3| 2| 4| 2| 3| 2| 3| 2| |
| 0| 4| 2| 2| 1| 1| 9| 0| 2| 0| 8| 5| 5| 8| 0| 0| 8| 1| 8| 3| 9| 2| 8| 0| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + A + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + A + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +| 47 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + A + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +| 46 |
Inflammation, Chronic, Focal | 3 | 1 3.0|
Ulcer, Chronic, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | | 1 2.0|
Basophilic Focus | | 1 |
Clear Cell Focus | X | 1 |
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 2 2 2 2 2 | 15 1.9|
Necrosis, Acute, Multifocal | | 1 2.0|
Hepatocyte, Karyomegaly, Focal | | 1 2.0|
Periportal, Inflammation, Multifocal | | 1 2.0|
Sinusoid, Infiltration Cellular, | | |
Diffuse, Polymorphonuclear | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Acinus, Atrophy, Diffuse | 4 | 1 4.0|
Acinus, Atrophy, Focal | | 1 2.0|
Acinus, Atrophy, Multifocal | 4 | 1 4.0|
Duct, Cyst, Multiple | X | 1 |
Duct, Inflammation, Chronic, | | |
Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + M + + + M + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Necrosis, Acute, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 1| 3| 3| 0| 3| 2| 3| 7| 3| 2| 9| 9| 2| 3| 3| 2| 3| 2| 4| 2| 3| 2| 3| 2| |
| 0| 4| 2| 2| 1| 1| 9| 0| 2| 0| 8| 5| 5| 8| 0| 0| 8| 1| 8| 3| 9| 2| 8| 0| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Capsule, Cyst | X | 1 |
Capsule, Hyperplasia, Cystic, | | |
Glandular, Multifocal | 3 | 1 3.0|
Capsule, Hyperplasia, Multifocal | 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 3 3 3 3 3| 48 2.9|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 |
Hyperplasia, Focal | | 1 2.0|
Hyperplasia, Multifocal | 2 | 1 2.0|
Hypertrophy, Focal | 2| 2 2.0|
Hypertrophy, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M M M + + + + + + + M + + + + +| 37 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + M M + + + + + + + + + + + +| 46 |
Pars Distalis, Cyst | X | 3 |
Pars Distalis, Cyst, Multiple | X | 1 |
Pars Distalis, Hyperplasia, Focal | 2 3 2 | 5 2.2|
Pars Distalis, Hyperplasia, | | |
Multifocal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Necrosis, Acute, Focal | 2 | 1 2.0|
Follicular Cell, Hyperplasia, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Multifocal | 3 | 1 3.0|
Thrombosis, Chronic Active | X | 1 |
Follicle, Cyst | X X X | 10 |
Follicle, Cyst, Multiple | X X X | 3 |
Periovarian Tissue, Cyst | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 1| 3| 3| 0| 3| 2| 3| 7| 3| 2| 9| 9| 2| 3| 3| 2| 3| 2| 4| 2| 3| 2| 3| 2| |
| 0| 4| 2| 2| 1| 1| 9| 0| 2| 0| 8| 5| 5| 8| 0| 0| 8| 1| 8| 3| 9| 2| 8| 0| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Endometrium, Angiectasis, Multifocal | | 1 3.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular, Multifocal | 2 2 4 3 4 4 3 4 3 2 2 3 2 3 1 3 3 3 3 3 4 2| 45 2.9|
Myometrium, Angiectasis, Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + A + + + I + + + + + + + + + + + + + + + + + + +| 48 |
Femoral, Angiectasis, Focal | | 1 3.0|
Femoral, Myelofibrosis, Multifocal | 2 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + M + + + + + + + + + + + M + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + M + + + + + + + M + + + + +| 46 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M M M M M M + M + M M + + M M M M M M M M M M M M| 8 |
Lymphatic, Ectasia, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoid Follicle, Necrosis, Acute, | | |
Multifocal | 3 | 1 3.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | 1 1 1 2 1 3 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1| 48 1.4|
Red Pulp, Pigmentation, Hemosiderin, | | |
Multifocal | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 45 1.1|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + M + + + + + + + M + + M M +| 41 |
Necrosis, Acute, Multifocal | 3 | 1 3.0|
Medulla, Thymocyte, Hyperplasia, | | |
Diffuse | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + M M + + M + + M + + + + + M + M + + +| 38 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite External | | 3 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + I + + + + + + + + + + + + + + + + + + +| 49 |
Bilateral, Joint, Tarsal, | | |
Hyperostosis | | 1 2.0|
Bilateral, Joint, Tarsal, Metaplasia,| | |
Multifocal, Osseous | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 1| 3| 3| 0| 3| 2| 3| 7| 3| 2| 9| 9| 2| 3| 3| 2| 3| 2| 4| 2| 3| 2| 3| 2| |
| 0| 4| 2| 2| 1| 1| 9| 0| 2| 0| 8| 5| 5| 8| 0| 0| 8| 1| 8| 3| 9| 2| 8| 0| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage, Multifocal | | 1 2.0|
Meninges, Infiltration Cellular, | | |
Multifocal, Lymphocyte | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitium, Inflammation, Chronic, | | |
Multifocal | | 2 2.0|
Interstitium, Inflammation, Chronic | | |
Active, Multifocal | 2 | 1 2.0|
Mediastinum, Foreign Body, Multifocal| 4 | 1 4.0|
Perivascular, Hyperplasia, Lymphoid, | | |
Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active, Diffuse| | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic, Diffuse | 4 | 1 4.0|
Nephropathy, Chronic, Focal | | 3 2.3|
Nephropathy, Chronic, Multifocal | 2 | 1 2.0|
Glomerulus, Amyloid Deposition, | | |
Multifocal | 4 | 1 4.0|
Renal Tubule, Regeneration, Focal | 1 2 2 | 3 1.7|
Renal Tubule, Regeneration, | | |
Multifocal | | 4 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 7| 5| 0| 7| 0| 7| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 1| 2| 0| 3| 0| 3| 2| 3| 3| 3| 0| 3| 8| 2| 3| 3| 3| 0| 2| 3| 2| 3| 2| 2|
| 9| 4| 8| 1| 1| 1| 1| 8| 1| 2| 1| 2| 1| 2| 9| 0| 1| 2| 9| 9| 0| 8| 2| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
3 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + |
__________________________________________________________________________|
Gallbladder | + + + A |
__________________________________________________________________________|
Intestine Large | + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + M |
__________________________________________________________________________|
Intestine Large, Colon | + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + M |
__________________________________________________________________________|
Intestine Small | + + + A |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X|
Hematopoietic Cell Proliferation, | |
Multifocal | 2 3 1 1 1 1 2 2 3 2 1 2 2 2 2 1|
Necrosis, Acute, Multifocal | |
Bile Duct, Cyst | |
Hepatocyte, Karyomegaly, Focal | 2 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic Active, | |
Multifocal | 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + |
Inflammation, Chronic Active, | |
Multifocal | 3 |
Acinus, Atrophy, Multifocal | 3 |
Duct, Cyst | X |
__________________________________________________________________________|
Salivary Glands | + + + + |
__________________________________________________________________________|
Stomach | + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + |
__________________________________________________________________________|
Tooth | + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + |
Epicardium, Inflammation, Acute, | |
Multifocal | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + |
Capsule, Hyperplasia, Multifocal | 3 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + |
__________________________________________________________________________|
Parathyroid Gland | + M M M |
__________________________________________________________________________|
Pituitary Gland | + + + M |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 7| 5| 0| 7| 0| 7| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 1| 2| 0| 3| 0| 3| 2| 3| 3| 3| 0| 3| 8| 2| 3| 3| 3| 0| 2| 3| 2| 3| 2| 2|
| 9| 4| 8| 1| 1| 1| 1| 8| 1| 2| 1| 2| 1| 2| 9| 0| 1| 2| 9| 9| 0| 8| 2| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
3 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + M + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + |
Thrombosis, Chronic Active | |
Follicle, Cyst | X X X |
Periovarian Tissue, Cyst | X |
Periovarian Tissue, Inflammation, | |
Chronic Active, Multifocal | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Multifocal, | |
Suppurative | 4 |
Endometrium, Hyperplasia, Cystic, | |
Glandular, Multifocal | 3 2 3 4 3 3 3 3 3 3 3 2 3 4 4 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + |
__________________________________________________________________________|
Lymph Node | + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | M M M M |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Follicle, Necrosis, Acute, | |
Multifocal | 2 2 |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 2 4 4 2 2 2 2 2 2 3 2 2 2 4 2 2 2 2 2 2 2 2 2 2 2|
Red Pulp, Pigmentation, Hemosiderin, | |
Multifocal | 2 2 2 2 1 2 2 2 2 3 2 2 3 2 2 3 2 2 2 2 2 2|
__________________________________________________________________________|
Thymus | M + + + |
Necrosis, Acute, Multifocal | 3 3 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + M +|
__________________________________________________________________________|
Skin | + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 7| 5| 0| 7| 0| 7| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 1| 2| 0| 3| 0| 3| 2| 3| 3| 3| 0| 3| 8| 2| 3| 3| 3| 0| 2| 3| 2| 3| 2| 2|
| 9| 4| 8| 1| 1| 1| 1| 8| 1| 2| 1| 2| 1| 2| 9| 0| 1| 2| 9| 9| 0| 8| 2| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
3 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Mediastinum, Foreign Body, Multifocal| 3 3 4 |
Pleura, Inflammation, Acute, Diffuse | 3 |
__________________________________________________________________________|
Nose | + + + + |
__________________________________________________________________________|
Trachea | + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic Active,| |
Diffuse, Necrotizing | 4 |
__________________________________________________________________________|
Harderian Gland | + + M + M |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + |
Renal Tubule, Cytoplasmic Alteration,| |
Diffuse | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 2| 3| 2| 2| 3| 3| 3| 3| 2| 3| 2| 2| 3| 2| 2| 3| 3| 3| 2| 2| 3| |
| 8| 0| 2| 1| 9| 2| 8| 8| 1| 1| 2| 2| 9| 2| 9| 9| 2| 9| 9| 9| 1| 2| 8| 8| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
3 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 5 |
__________________________________________________________________________|____________|
Gallbladder | A | 3 |
__________________________________________________________________________|____________|
Intestine Large | + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 4 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 4 |
__________________________________________________________________________|____________|
Intestine Small | + | 4 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 4 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 4 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 4 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | X | 2 |
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 2 2 1 1 2 2 2 2 2 2 2 2| 29 1.8|
Necrosis, Acute, Multifocal | 2 | 1 2.0|
Bile Duct, Cyst | X | 1 |
Hepatocyte, Karyomegaly, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Inflammation, Chronic Active, | | |
Multifocal | | 2 4.0|
__________________________________________________________________________|____________|
Pancreas | + + | 7 |
Inflammation, Chronic Active, | | |
Multifocal | | 1 3.0|
Acinus, Atrophy, Multifocal | | 1 3.0|
Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + | 5 |
__________________________________________________________________________|____________|
Stomach | + | 5 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 5 |
__________________________________________________________________________|____________|
Tooth | + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 5 |
Epicardium, Inflammation, Acute, | | |
Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + | 5 |
Capsule, Hyperplasia, Multifocal | 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 2| 3| 2| 2| 3| 3| 3| 3| 2| 3| 2| 2| 3| 2| 2| 3| 3| 3| 2| 2| 3| |
| 8| 0| 2| 1| 9| 2| 8| 8| 1| 1| 2| 2| 9| 2| 9| 9| 2| 9| 9| 9| 1| 2| 8| 8| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
3 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + | 5 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 5 |
__________________________________________________________________________|____________|
Parathyroid Gland | + | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + | 5 |
__________________________________________________________________________|____________|
Thyroid Gland | + | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + | 14 |
Thrombosis, Chronic Active | X | 1 |
Follicle, Cyst | X X X X | 7 |
Periovarian Tissue, Cyst | | 1 |
Periovarian Tissue, Inflammation, | | |
Chronic Active, Multifocal | | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + +| 38 |
Inflammation, Chronic, Multifocal, | | |
Suppurative | | 1 4.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular, Multifocal | 3 3 3 2 3 3 3 3 3 3 2 3 2 3 2 3 3 3 2| 35 2.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 5 |
__________________________________________________________________________|____________|
Lymph Node | + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoid Follicle, Necrosis, Acute, | | |
Multifocal | | 2 2.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 3 3 2 2| 50 2.2|
Red Pulp, Pigmentation, Hemosiderin, | | |
Multifocal | 2 3 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2| 47 2.1|
__________________________________________________________________________|____________|
Thymus | + | 4 |
Necrosis, Acute, Multifocal | | 3 3.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 2| 3| 2| 2| 3| 3| 3| 3| 2| 3| 2| 2| 3| 2| 2| 3| 3| 3| 2| 2| 3| |
| 8| 0| 2| 1| 9| 2| 8| 8| 1| 1| 2| 2| 9| 2| 9| 9| 2| 9| 9| 9| 1| 2| 8| 8| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
3 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 5 |
__________________________________________________________________________|____________|
Skin | + | 7 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 6 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + | 8 |
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
Mediastinum, Foreign Body, Multifocal| | 3 3.3|
Pleura, Inflammation, Acute, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + | 5 |
__________________________________________________________________________|____________|
Trachea | + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cornea, Inflammation, Chronic Active,| | |
Diffuse, Necrotizing | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 7 |
Renal Tubule, Cytoplasmic Alteration,| | |
Diffuse | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 2| 3| 3| 3| 3| 3| 6| 2| 0| 2| 2| 3| 2| 3| 5| 3| 0| 2| 3| 2| 2| 3|
| 1| 9| 8| 8| 1| 2| 2| 2| 0| 7| 9| 4| 9| 8| 2| 8| 1| 0| 2| 9| 9| 2| 8| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + A + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
Lumen, Pigmentation, Diffuse | 3 |
Mucosa, Cyst | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + +|
Necrosis, Acute, Diffuse | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Cytomegaly, Focal | 3 |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 2 2 2 2 2 2 2 2 2 2 3 1 2 2 2 2|
Necrosis, Acute, Multifocal | 3 |
Thrombosis, Chronic | |
Vacuolization Cytoplasmic, Focal | 3 |
Centrilobular, Necrosis, Acute, | |
Multifocal | |
Kupffer Cell, Pigmentation, | |
Hemosiderin | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Serosa, Inflammation, Chronic, | |
Multifocal, Suppurative | |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic, Multifocal, | |
Suppurative | 3 |
Inflammation, Chronic Active, | |
Multifocal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Multifocal, | |
Suppurative | 3 |
Acinus, Atrophy, Focal | 2 |
Acinus, Atrophy, Multifocal | 2 2 |
Duct, Cyst | |
Duct, Ectasia, Focal | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 3 2 2 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 2| 3| 3| 3| 3| 3| 6| 2| 0| 2| 2| 3| 2| 3| 5| 3| 0| 2| 3| 2| 2| 3|
| 1| 9| 8| 8| 1| 2| 2| 2| 0| 7| 9| 4| 9| 8| 2| 8| 1| 0| 2| 9| 9| 2| 8| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acinus, Atrophy, Focal | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + M + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | 2 |
Hyperkeratosis, Focal | 2 |
Ulcer, Acute, Focal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + + + +|
Cyst | X |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Coronary Artery, Inflammation, | |
Chronic Active, Multifocal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia, Focal | |
Capsule, Hyperplasia, Multifocal | 3 3 3 3 3 3 3 3 3 3 3 2 3 3 3 3 3 2 3 2 3 3 3 3 3|
Corticomedullary Junction, | |
Degeneration, Fatty, Multifocal | 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty, Focal | 2 |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 |
Hyperplasia, Focal | |
Hypertrophy, Focal | |
Hypertrophy, Multifocal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, Plasma | |
Cell | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + M + + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + M M + + + + + + + + + + + I + + + + + + M + + I|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Focal | 2 |
Follicular Cell, Hyperplasia | 3 |
Follicular Cell, Hyperplasia, | |
Multifocal | 2 |
Interstitium, Inflammation, Chronic, | |
Focal | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 2| 3| 3| 3| 3| 3| 6| 2| 0| 2| 2| 3| 2| 3| 5| 3| 0| 2| 3| 2| 2| 3|
| 1| 9| 8| 8| 1| 2| 2| 2| 0| 7| 9| 4| 9| 8| 2| 8| 1| 0| 2| 9| 9| 2| 8| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Inflammation, Chronic, Multifocal, | |
Suppurative | 4 |
Corpus Luteum, Angiectasis, | |
Multifocal | |
Follicle, Cyst | X X X X X X X |
Follicle, Cyst, Multiple | X |
Periovarian Tissue, Cyst | |
Periovarian Tissue, Infiltration | |
Cellular, Multifocal, Lymphocyte | 3 |
Rete Ovarii, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Multifocal, | |
Suppurative | 3 |
Endometrium, Hyperplasia, Cystic, | |
Glandular, Multifocal | 3 2 3 3 3 3 3 2 3 2 3 3 3 3 2 2 3 3 4 3 4 3|
Mucosa, Metaplasia, Multifocal, | |
Squamous | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
Neutrophilia | X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Diffuse, | |
Neutrophil | 3 3 |
Femoral, Myelofibrosis, Multifocal | 2 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + M + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Diffuse, | |
Lymphoid | 4 |
Renal, Hyperplasia, Diffuse, Lymphoid| 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia, Diffuse, Lymphoid | 4 |
Hyperplasia, Multifocal, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | M M M M M + M M M M M M M M M + M M M M M M M M M|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia, Multifocal | 2 |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 2 1 2 3 2 2 2 3 1 3 2 4 2 2 2 2 3 4 2 2 2 2 2 2|
Red Pulp, Pigmentation, Hemosiderin, | |
Multifocal | 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Thymus | + + M M + + + M + M + M + + + M + + + M + + + M M|
Depletion Lymphoid, Multifocal | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 2| 3| 3| 3| 3| 3| 6| 2| 0| 2| 2| 3| 2| 3| 5| 3| 0| 2| 3| 2| 2| 3|
| 1| 9| 8| 8| 1| 2| 2| 2| 0| 7| 9| 4| 9| 8| 2| 8| 1| 0| 2| 9| 9| 2| 8| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | |
Cranium, Hyperostosis, Focal | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression, Focal | 3 |
Meninges, Infiltration Cellular, | |
Multifocal, Lymphocyte | 2 |
Meninges, Inflammation, Chronic | |
Active, Multifocal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolus, Hemorrhage, Multifocal | 3 |
Interstitium, Inflammation, Chronic | |
Active, Focal | |
Perivascular, Inflammation, Chronic, | |
Multifocal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | I + |
Degeneration, Diffuse | 4 |
__________________________________________________________________________|
Harderian Gland | + M + + + + + + + + + + + + + + + + + M + + + + +|
Acinus, Hyperplasia, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | |
Nephropathy, Chronic, Focal | |
Nephropathy, Chronic, Multifocal | |
Glomerulus, Inflammation, Chronic, | |
Multifocal | 2 |
Perivascular, Infiltration Cellular, | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 2| 3| 3| 3| 3| 3| 6| 2| 0| 2| 2| 3| 2| 3| 5| 3| 0| 2| 3| 2| 2| 3|
| 1| 9| 8| 8| 1| 2| 2| 2| 0| 7| 9| 4| 9| 8| 2| 8| 1| 0| 2| 9| 9| 2| 8| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Multifocal, Plasma Cell | 2 |
Renal Tubule, Dilatation, Diffuse | |
Renal Tubule, Pigmentation, | |
Hemosiderin, Multifocal | 2 2 1 1 2 1 1 1 2 1 1 1 2 1 1 1 1 1 1 1 1|
Renal Tubule, Regeneration, | |
Multifocal | 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + I A + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 5| 1| 2| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2| |
| 1| 2| 8| 6| 9| 2| 1| 0| 0| 1| 1| 0| 9| 2| 7| 2| 0| 8| 1| 1| 0| 2| 1| 2| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
30 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + A A + + + + + + + + + + + A + + + + + + + + + +| 46 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 2.0|
Lumen, Pigmentation, Diffuse | | 1 3.0|
Mucosa, Cyst | X | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
Necrosis, Acute, Diffuse | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 1 |
Cytomegaly, Focal | | 1 3.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 2 3 3 2 2 2 2 2 2 2 2 2 2| 31 2.1|
Necrosis, Acute, Multifocal | | 1 3.0|
Thrombosis, Chronic | X | 1 |
Vacuolization Cytoplasmic, Focal | | 1 3.0|
Centrilobular, Necrosis, Acute, | | |
Multifocal | 3 | 1 3.0|
Kupffer Cell, Pigmentation, | | |
Hemosiderin | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 46 2.0|
Serosa, Inflammation, Chronic, | | |
Multifocal, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + | 3 |
Inflammation, Chronic, Multifocal, | | |
Suppurative | 3 | 2 3.0|
Inflammation, Chronic Active, | | |
Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Inflammation, Chronic, Multifocal, | | |
Suppurative | | 1 3.0|
Acinus, Atrophy, Focal | 2 | 2 2.0|
Acinus, Atrophy, Multifocal | 4 2 3 | 5 2.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 5| 1| 2| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2| |
| 1| 2| 8| 6| 9| 2| 1| 0| 0| 1| 1| 0| 9| 2| 7| 2| 0| 8| 1| 1| 0| 2| 1| 2| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
30 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Duct, Cyst | X | 1 |
Duct, Ectasia, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + M + + + + + + A + + + + + + + + + +| 48 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 3 2.3|
Acinus, Atrophy, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + A + + + + + + + + + + + + M + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + A + + + + + M + + + + + + M + + + + + + + + + +| 46 |
Acanthosis, Focal | | 1 2.0|
Hyperkeratosis, Focal | | 1 2.0|
Ulcer, Acute, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + + + + + + + + + M + + + + + + + + + +| 47 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Coronary Artery, Inflammation, | | |
Chronic Active, Multifocal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Capsule, Hyperplasia, Focal | 3 | 1 3.0|
Capsule, Hyperplasia, Multifocal | 3 2 2 2 3 3 3 3 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3| 48 2.9|
Corticomedullary Junction, | | |
Degeneration, Fatty, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Degeneration, Fatty, Focal | | 1 2.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | | 1 2.0|
Hyperplasia, Focal | 2 | 1 2.0|
Hypertrophy, Focal | 2 3 | 2 2.5|
Hypertrophy, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Infiltration Cellular, Focal, Plasma | | |
Cell | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + M + M + + + + M + + + + + + + + + +| 42 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 5| 1| 2| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2| |
| 1| 2| 8| 6| 9| 2| 1| 0| 0| 1| 1| 0| 9| 2| 7| 2| 0| 8| 1| 1| 0| 2| 1| 2| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
30 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia, Focal | 1 2 2 | 6 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Follicular Cell, Hyperplasia, Focal | | 1 2.0|
Follicular Cell, Hyperplasia | | 1 3.0|
Follicular Cell, Hyperplasia, | | |
Multifocal | | 1 2.0|
Interstitium, Inflammation, Chronic, | | |
Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + I + + A M + + + + + + + + +| 47 |
Angiectasis, Focal | 2 | 1 2.0|
Inflammation, Chronic, Multifocal, | | |
Suppurative | 4 | 2 4.0|
Corpus Luteum, Angiectasis, | | |
Multifocal | 3 | 1 3.0|
Follicle, Cyst | X X X X X X X | 14 |
Follicle, Cyst, Multiple | | 1 |
Periovarian Tissue, Cyst | X | 1 |
Periovarian Tissue, Infiltration | | |
Cellular, Multifocal, Lymphocyte | | 1 3.0|
Rete Ovarii, Cyst | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + A M + + + + + + + + +| 48 |
Inflammation, Chronic, Multifocal, | | |
Suppurative | 4 | 2 3.5|
Endometrium, Hyperplasia, Cystic, | | |
Glandular, Multifocal | 2 2 1 2 2 3 2 3 3 2 3 4 3 2 3 4 3 3 2 3 4| 43 2.8|
Mucosa, Metaplasia, Multifocal, | | |
Squamous | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 3 |
Neutrophilia | X | 3 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Femoral, Hyperplasia, Diffuse, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 5| 1| 2| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2| |
| 1| 2| 8| 6| 9| 2| 1| 0| 0| 1| 1| 0| 9| 2| 7| 2| 0| 8| 1| 1| 0| 2| 1| 2| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
30 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Neutrophil | | 2 3.0|
Femoral, Myelofibrosis, Multifocal | 2 2 | 4 1.8|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + M + + + + + + A + + + + + + + + + +| 47 |
Mediastinal, Hyperplasia, Diffuse, | | |
Lymphoid | 3 | 2 3.5|
Renal, Hyperplasia, Diffuse, Lymphoid| | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + A + + + + + + + + + +| 47 |
Hyperplasia, Diffuse, Lymphoid | | 1 4.0|
Hyperplasia, Multifocal, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M M M M M M M M M M + M M M A M M M M M M M M M M| 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Capsule, Hyperplasia, Multifocal | | 1 2.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | 2 3 4 3 2 2 2 3 2 3 1 2 2 2 2 3 2 2 2 2 2 3 2 2| 48 2.3|
Red Pulp, Pigmentation, Hemosiderin, | | |
Multifocal | 2 2 2 2 2 2 2 2 2 2 1 2 3 2 2 2 2 2 2 2 2 2 2 2| 49 2.0|
__________________________________________________________________________|____________|
Thymus | + + M M + + M + + + + M + + M + + + + + + + M + +| 35 |
Depletion Lymphoid, Multifocal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + + M + + + M M M + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Fibrous Osteodystrophy | X | 1 |
Cranium, Hyperostosis, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Hypothalamus, Compression, Focal | | 1 3.0|
Meninges, Infiltration Cellular, | | |
Multifocal, Lymphocyte | 2 | 2 2.0|
Meninges, Inflammation, Chronic | | |
Active, Multifocal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 5| 1| 2| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2| |
| 1| 2| 8| 6| 9| 2| 1| 0| 0| 1| 1| 0| 9| 2| 7| 2| 0| 8| 1| 1| 0| 2| 1| 2| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
30 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 2 | 3 2.0|
Alveolus, Hemorrhage, Multifocal | | 1 3.0|
Interstitium, Inflammation, Chronic | | |
Active, Focal | 2 | 1 2.0|
Perivascular, Inflammation, Chronic, | | |
Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Degeneration, Diffuse | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| 47 |
Acinus, Hyperplasia, Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Mineralization, Multifocal | 2 | 1 2.0|
Nephropathy, Chronic, Focal | 2 | 1 2.0|
Nephropathy, Chronic, Multifocal | 2 | 1 2.0|
Glomerulus, Inflammation, Chronic, | | |
Multifocal | 2 2 | 3 2.0|
Perivascular, Infiltration Cellular, | | |
Multifocal, Plasma Cell | | 1 2.0|
Renal Tubule, Dilatation, Diffuse | 3 | 1 3.0|
Renal Tubule, Pigmentation, | | |
Hemosiderin, Multifocal | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 | 38 1.2|
Renal Tubule, Regeneration, | | |
Multifocal | 2 | 3 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + + + + + + + + + A M + + + + I + + + +| 44 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 3| 2| 3| 2| 2| 2| 2| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 2|
| 8| 0| 9| 2| 9| 0| 9| 5| 8| 9| 0| 8| 0| 0| 0| 2| 0| 9| 0| 1| 2| 1| 0| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + |
__________________________________________________________________________|
Gallbladder | A |
__________________________________________________________________________|
Intestine Large | + |
__________________________________________________________________________|
Intestine Large, Cecum | A |
__________________________________________________________________________|
Intestine Large, Colon | + |
__________________________________________________________________________|
Intestine Large, Rectum | A |
__________________________________________________________________________|
Intestine Small | + |
__________________________________________________________________________|
Intestine Small, Duodenum | + |
__________________________________________________________________________|
Intestine Small, Ileum | + |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytomegaly, Focal | 2 |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 2 2 2 2 2 3 1 2 2 2|
Necrosis, Acute, Multifocal | |
Vacuolization Cytoplasmic, Focal | |
Kupffer Cell, Pigmentation, | |
Hemosiderin | 2 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic Active, | |
Multifocal | 2 |
__________________________________________________________________________|
Pancreas | + |
Inflammation, Chronic Active, | |
Multifocal | |
Acinus, Atrophy, Multifocal | |
Duct, Ectasia, Multifocal | |
__________________________________________________________________________|
Salivary Glands | + |
__________________________________________________________________________|
Stomach | + + |
__________________________________________________________________________|
Stomach, Forestomach | + |
__________________________________________________________________________|
Stomach, Glandular | + |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + |
Atrium, Inflammation, Chronic, Focal | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + |
Capsule, Hyperplasia, Multifocal | 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + |
__________________________________________________________________________|
Islets, Pancreatic | + |
__________________________________________________________________________|
Parathyroid Gland | + |
__________________________________________________________________________|
Pituitary Gland | + + + |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 3| 2| 3| 2| 2| 2| 2| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 2|
| 8| 0| 9| 2| 9| 0| 9| 5| 8| 9| 0| 8| 0| 0| 0| 2| 0| 9| 0| 1| 2| 1| 0| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + +|
Angiectasis, Multifocal | 3|
Follicle, Cyst | X X X X X X X |
Periovarian Tissue, Cyst | X X X|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic, | |
Glandular, Multifocal | 3 3 2 3 2 2 3 3 4 2 2 2 2 3 3 3 3 3 2 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + |
__________________________________________________________________________|
Lymph Node | + + + + |
Pancreatic, Inflammation, Chronic | |
Active, Multifocal | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + |
Lymphatic, Angiectasis, Diffuse | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + |
Cyst | |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Inflammation, Chronic | |
Active, Multifocal | |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 2 2 2 3 2 2 2 4 3 2 2 2 2 2 2 3 4 2 2 2 3 2 2 3 3|
Red Pulp, Pigmentation, Hemosiderin, | |
Multifocal | 2 2 2 2 3 2 3 2 2 3 2 3 2 2 2 2 1 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Thymus | M |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + |
Hyperplasia, Cystic, Multifocal | 1 |
__________________________________________________________________________|
Skin | + + + + |
Ulcer | 3 4 |
Subcutaneous Tissue, Fibrosis, | |
Multifocal | 3 |
Subcutaneous Tissue, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 3| 2| 3| 2| 2| 2| 2| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 2|
| 8| 0| 9| 2| 9| 0| 9| 5| 8| 9| 0| 8| 0| 0| 0| 2| 0| 9| 0| 1| 2| 1| 0| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Chronic Active, Multifocal | 3 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + |
Necrosis, Acute, Multifocal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + |
Alveolus, Hemorrhage, Multifocal | 2 |
__________________________________________________________________________|
Nose | + |
__________________________________________________________________________|
Trachea | + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + |
Inflammation, Chronic Active, | |
Multifocal | 3 |
Capsule, Fibrosis, Chronic, Focal | 2 |
__________________________________________________________________________|
Urinary Bladder | + |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 2| 7| 2| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 3| |
| 9| 1| 2| 2| 0| 8| 9| 2| 1| 9| 1| 8| 9| 9| 0| 8| 2| 2| 7| 1| 0| 1| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
10 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 3 |
__________________________________________________________________________|____________|
Gallbladder | + + M | 2 |
__________________________________________________________________________|____________|
Intestine Large | + + | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + | 3 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 3 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + M | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cytomegaly, Focal | | 1 2.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 2 3 2 2 2 2 2 1 2 2 2 2| 24 2.0|
Necrosis, Acute, Multifocal | 2 | 1 2.0|
Vacuolization Cytoplasmic, Focal | 2 | 1 2.0|
Kupffer Cell, Pigmentation, | | |
Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Inflammation, Chronic Active, | | |
Multifocal | 4 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + | 5 |
Inflammation, Chronic Active, | | |
Multifocal | 4 | 1 4.0|
Acinus, Atrophy, Multifocal | 3 3 | 2 3.0|
Duct, Ectasia, Multifocal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + | 3 |
__________________________________________________________________________|____________|
Stomach | + + | 4 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 3 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 3 |
__________________________________________________________________________|____________|
Tooth | + + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 3 |
Atrium, Inflammation, Chronic, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + | 4 |
Capsule, Hyperplasia, Multifocal | 2 3 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 2| 7| 2| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 3| |
| 9| 1| 2| 2| 0| 8| 9| 2| 1| 9| 1| 8| 9| 9| 0| 8| 2| 2| 7| 1| 0| 1| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
10 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + | 4 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 4 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + | 3 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 6 |
Pars Distalis, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + +| 17 |
Angiectasis, Multifocal | | 1 3.0|
Follicle, Cyst | X X X X | 11 |
Periovarian Tissue, Cyst | X X| 5 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +| 42 |
Endometrium, Hyperplasia, Cystic, | | |
Glandular, Multifocal | 3 3 2 3 3 3 4 3 4 2 3 3 2 3 2 2 3 3 3 2 3| 41 2.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + | 3 |
__________________________________________________________________________|____________|
Lymph Node | + M + + | 7 |
Pancreatic, Inflammation, Chronic | | |
Active, Multifocal | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M | 5 |
Lymphatic, Angiectasis, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M M + | 4 |
Cyst | X | 1 |
Hematopoietic Cell Proliferation, | | |
Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Capsule, Inflammation, Chronic | | |
Active, Multifocal | 3 | 1 3.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | 2 2 3 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2| 49 2.2|
Red Pulp, Pigmentation, Hemosiderin, | | |
Multifocal | 2 1 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 49 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 2| 7| 2| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 3| |
| 9| 1| 2| 2| 0| 8| 9| 2| 1| 9| 1| 8| 9| 9| 0| 8| 2| 2| 7| 1| 0| 1| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
10 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | M + | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 3 |
Hyperplasia, Cystic, Multifocal | 2 | 2 1.5|
__________________________________________________________________________|____________|
Skin | + + + | 7 |
Ulcer | | 2 3.5|
Subcutaneous Tissue, Fibrosis, | | |
Multifocal | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active, Multifocal | | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 3 |
Necrosis, Acute, Multifocal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 7 |
Alveolus, Hemorrhage, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + | 3 |
__________________________________________________________________________|____________|
Trachea | + + | 3 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + M | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 4 |
Inflammation, Chronic Active, | | |
Multifocal | | 1 3.0|
Capsule, Fibrosis, Chronic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 3| 3| 3| 7| 9| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 0| 9| 6| 2| 3| 3| 2|
| 2| 1| 1| 1| 0| 2| 6| 0| 0| 1| 0| 9| 2| 0| 2| 8| 1| 0| 2| 1| 7| 8| 1| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + A + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + M + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + M + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small | + A + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + A + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + A + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Clear Cell Focus, Focal | |
Hematopoietic Cell Proliferation, | |
Diffuse | 3 |
Hematopoietic Cell Proliferation, | |
Multifocal | 3 1 |
Necrosis, Chronic Active, Focal | 3 |
Centrilobular, Necrosis, Acute, | |
Multifocal | 2 |
Centrilobular, Vacuolization | |
Cytoplasmic, Diffuse | 2 3 2 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + A + + + + + +|
Acinus, Atrophy, Multifocal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Molar, Dysplasia | 3 |
Peridontal Tissue, Foreign Body, | |
Focal | 2 |
Peridontal Tissue, Foreign Body, | |
Multifocal | |
Peridontal Tissue, Inflammation, | |
Chronic Active, Focal | 2 |
Peridontal Tissue, Inflammation, | |
Chronic Active, Multifocal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 3| 3| 3| 7| 9| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 0| 9| 6| 2| 3| 3| 2|
| 2| 1| 1| 1| 0| 2| 6| 0| 0| 1| 0| 9| 2| 0| 2| 8| 1| 0| 2| 1| 7| 8| 1| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Capsule, Ectopic Tissue | X X |
Capsule, Hyperplasia, Focal | 2 2 |
Capsule, Hyperplasia, Multifocal | 3 2 1 2 2 2 1 2 2 3 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia, Focal | 2 2 2 2 |
Hypertrophy, Focal | 2 2 2 2 2 2 |
Hypertrophy, Multifocal | 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M M + M + + + + M M M + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + M + + M M + + + M + + + M M M|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, | |
Multifocal | 2 |
Follicle, Cyst, Multiple | X |
Follicular Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | |
Atrophy, Diffuse | |
Inflammation, Chronic Active, Diffuse| |
Duct, Dilatation, Multifocal | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + M + + + + + + M +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Neutrophilia | 3 |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Diffuse, Neutrophil | 4 |
Hyperplasia, Multifocal, Neutrophil | |
Thrombosis, Chronic Active | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + M + +|
Mediastinal, Hematopoietic Cell | |
Proliferation, Diffuse | |
Mediastinal, Hematopoietic Cell | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 3| 3| 3| 7| 9| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 0| 9| 6| 2| 3| 3| 2|
| 2| 1| 1| 1| 0| 2| 6| 0| 0| 1| 0| 9| 2| 0| 2| 8| 1| 0| 2| 1| 7| 8| 1| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Proliferation, Multifocal | 3 |
Pancreatic, Hematopoietic Cell | |
Proliferation, Multifocal | |
Renal, Hyperplasia, Multifocal, | |
Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M + +|
Hematopoietic Cell Proliferation, | |
Multifocal | 3 |
Hyperplasia, Lymphoid, Multifocal | 3 |
Hyperplasia, Multifocal, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + M M M + + M M M M + + + + + M M + M M M M M|
Hematopoietic Cell Proliferation, | |
Multifocal | 2 2 3 |
Hemorrhage, Multifocal | 2 2 2 2 |
Hyperplasia, Diffuse, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Red Pulp, Fibrosis | |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 1 2 2 2 1 4 3 1 2 1 1 1 1 2 2 1 2 1 3 4 3 3 1 1 1|
Red Pulp, Pigmentation, Hemosiderin, | |
Multifocal | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + M M I + M + M M + M + + M|
Necrosis, Acute, Multifocal | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Diffuse | 2 |
Acanthosis, Multifocal | 2 3 |
Hyperkeratosis, Multifocal | |
Parasite External | X X X |
Ulcer | 3 |
Subcutaneous Tissue, Fibrosis, | |
Diffuse | 3 |
Subcutaneous Tissue, Fibrosis, Focal | |
Subcutaneous Tissue, Fibrosis, | |
Multifocal | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Joint, Radius, | |
Hyperostosis | 3 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 3| 3| 3| 7| 9| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 0| 9| 6| 2| 3| 3| 2|
| 2| 1| 1| 1| 0| 2| 6| 0| 0| 1| 0| 9| 2| 0| 2| 8| 1| 0| 2| 1| 7| 8| 1| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Bilateral, Joint, Tarsal, | |
Hyperostosis | 3 2 3 3 |
Bilateral, Joint, Tarsal, Metaplasia,| |
Multifocal, Osseous | 2 2 2 2 |
Joint, Tarsal, Hyperostosis | 3 3 3 2 2 3 3 |
Joint, Tarsal, Metaplasia, | |
Multifocal, Osseous | 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 |
Interstitium, Inflammation, Chronic | |
Active, Focal | |
Interstitium, Inflammation, Chronic | |
Active, Multifocal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Dilatation, Diffuse | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic, Focal | 3 2|
Nephropathy, Chronic, Multifocal | 3 2 |
Bilateral, Hydronephrosis, Acute, | |
Multifocal | 2 |
Renal Tubule, Regeneration, Focal | |
Renal Tubule, Regeneration, | |
Multifocal | 2 2 2 2 1 1 2 2 2 1 2 2 2 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + M + + + + + + + +|
Dilatation | |
Submucosa, Congestion, Multifocal | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 3| 3| 5| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| |
| 8| 8| 8| 1| 2| 4| 2| 1| 0| 2| 0| 8| 2| 2| 1| 1| 0| 1| 0| 2| 1| 8| 1| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + A M + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 1 | 1 1.0|
Clear Cell Focus, Focal | X | 1 |
Hematopoietic Cell Proliferation, | | |
Diffuse | | 1 3.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 4 2 3 2 | 6 2.5|
Necrosis, Chronic Active, Focal | | 1 3.0|
Centrilobular, Necrosis, Acute, | | |
Multifocal | | 1 2.0|
Centrilobular, Vacuolization | | |
Cytoplasmic, Diffuse | 2 | 4 2.3|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy, Multifocal | 2 2 2 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Molar, Dysplasia | | 1 3.0|
Peridontal Tissue, Foreign Body, | | |
Focal | 2 | 2 2.0|
Peridontal Tissue, Foreign Body, | | |
Multifocal | 2 | 1 2.0|
Peridontal Tissue, Inflammation, | | |
Chronic Active, Focal | 2 3 | 3 2.3|
Peridontal Tissue, Inflammation, | | |
Chronic Active, Multifocal | 2 2 3 3 3 3| 6 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 3| 3| 5| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| |
| 8| 8| 8| 1| 2| 4| 2| 1| 0| 2| 0| 8| 2| 2| 1| 1| 0| 1| 0| 2| 1| 8| 1| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Capsule, Ectopic Tissue | | 2 |
Capsule, Hyperplasia, Focal | | 2 2.0|
Capsule, Hyperplasia, Multifocal | 2 2 3 2 2 2 2 2 2 2 2 3 2 2 1 3 2 2 2 2 2 2 2 2| 44 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 2 2 2 2 2 2 3 | 11 2.1|
Hypertrophy, Focal | 1 2 2 | 9 1.9|
Hypertrophy, Multifocal | 2 | 5 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M M + + + M M M + + + I M + + +| 36 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + M + + + + + M + + + + + + + +| 40 |
Pars Distalis, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active, | | |
Multifocal | | 1 2.0|
Follicle, Cyst, Multiple | | 1 |
Follicular Cell, Hyperplasia, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Preputial Gland | + + | 2 |
Atrophy, Diffuse | 4 4 | 2 4.0|
Inflammation, Chronic Active, Diffuse| 3 | 1 3.0|
Duct, Dilatation, Multifocal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + | 19 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 3| 3| 5| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| |
| 8| 8| 8| 1| 2| 4| 2| 1| 0| 2| 0| 8| 2| 2| 1| 1| 0| 1| 0| 2| 1| 8| 1| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 2 |
Neutrophilia | 4 | 2 3.5|
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Diffuse, Neutrophil | 3 3 | 3 3.3|
Hyperplasia, Multifocal, Neutrophil | 3 | 1 3.0|
Thrombosis, Chronic Active | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mediastinal, Hematopoietic Cell | | |
Proliferation, Diffuse | 3 | 1 3.0|
Mediastinal, Hematopoietic Cell | | |
Proliferation, Multifocal | 2 | 2 2.5|
Pancreatic, Hematopoietic Cell | | |
Proliferation, Multifocal | 3 | 1 3.0|
Renal, Hyperplasia, Multifocal, | | |
Plasma Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + I + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation, | | |
Multifocal | | 1 3.0|
Hyperplasia, Lymphoid, Multifocal | 2 | 2 2.5|
Hyperplasia, Multifocal, Plasma Cell | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M M + + M M M M + M + M + + M + + + + M + + M M M| 22 |
Hematopoietic Cell Proliferation, | | |
Multifocal | 3 3 3 2 3 3 2 | 10 2.6|
Hemorrhage, Multifocal | | 4 2.0|
Hyperplasia, Diffuse, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Red Pulp, Fibrosis | 2 | 1 2.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | 4 2 3 3 1 4 2 1 1 1 2 1 2 1 2 3 3 2 1 1 1 3 3 1 1| 50 1.9|
Red Pulp, Pigmentation, Hemosiderin, | | |
Multifocal | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 37 1.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + + + M M + + + + + + + M M| 36 |
Necrosis, Acute, Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + I + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis, Diffuse | | 1 2.0|
Acanthosis, Multifocal | 3 3 3 3 3 3 3 | 9 2.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 3| 3| 5| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| |
| 8| 8| 8| 1| 2| 4| 2| 1| 0| 2| 0| 8| 2| 2| 1| 1| 0| 1| 0| 2| 1| 8| 1| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperkeratosis, Multifocal | 3 | 1 3.0|
Parasite External | X X X X | 7 |
Ulcer | 2 3 4 2 4 | 6 3.0|
Subcutaneous Tissue, Fibrosis, | | |
Diffuse | | 1 3.0|
Subcutaneous Tissue, Fibrosis, Focal | 2 | 1 2.0|
Subcutaneous Tissue, Fibrosis, | | |
Multifocal | 2 3 3 4 3 | 5 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active, Multifocal | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | I + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Bilateral, Joint, Radius, | | |
Hyperostosis | | 1 3.0|
Bilateral, Joint, Tarsal, | | |
Hyperostosis | 3 3 3 2 3 2 | 10 2.7|
Bilateral, Joint, Tarsal, Metaplasia,| | |
Multifocal, Osseous | 2 2 2 2 2 2 | 10 2.0|
Joint, Tarsal, Hyperostosis | 3 3 2 2 | 11 2.6|
Joint, Tarsal, Metaplasia, | | |
Multifocal, Osseous | 2 2 2 2 | 11 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 3.0|
Interstitium, Inflammation, Chronic | | |
Active, Focal | 2 | 1 2.0|
Interstitium, Inflammation, Chronic | | |
Active, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 3| 3| 5| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| |
| 8| 8| 8| 1| 2| 4| 2| 1| 0| 2| 0| 8| 2| 2| 1| 1| 0| 1| 0| 2| 1| 8| 1| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Cataract | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Dilatation, Diffuse | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic, Focal | 2 | 3 2.3|
Nephropathy, Chronic, Multifocal | | 2 2.5|
Bilateral, Hydronephrosis, Acute, | | |
Multifocal | | 1 2.0|
Renal Tubule, Regeneration, Focal | 1 | 1 1.0|
Renal Tubule, Regeneration, | | |
Multifocal | 1 2 2 2 2 1 2 2 1 2 2 2 1 2 1 2 1| 33 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Dilatation | 3 | 1 3.0|
Submucosa, Congestion, Multifocal | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 2| 6| 7| 7|
DAY ON TEST | 2| 3| 7| 3| 3| 3| 2| 3| 3| 1| 2| 7| 3| 0| 3| 6| 3| 3| 3| 2| 2| 4| 7| 2| 3|
| 9| 1| 9| 2| 0| 3| 8| 2| 0| 4| 9| 4| 0| 8| 2| 7| 2| 1| 2| 8| 9| 6| 4| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
3 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + |
__________________________________________________________________________|
Gallbladder | A A |
__________________________________________________________________________|
Intestine Large | + + + |
__________________________________________________________________________|
Intestine Large, Cecum | A A |
__________________________________________________________________________|
Intestine Large, Colon | + + + |
Inflammation, Acute, Multifocal, | |
Necrotizing | 3 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | A A |
__________________________________________________________________________|
Intestine Small | A + |
__________________________________________________________________________|
Intestine Small, Duodenum | A + |
__________________________________________________________________________|
Intestine Small, Ileum | A + |
__________________________________________________________________________|
Intestine Small, Jejunum | A + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 2 |
Inflammation | 1 |
Necrosis, Chronic Active, Multifocal | 4 |
Vacuolization Cytoplasmic, Focal | 2 |
__________________________________________________________________________|
Pancreas | A + |
__________________________________________________________________________|
Salivary Glands | + + |
__________________________________________________________________________|
Stomach | + + |
__________________________________________________________________________|
Stomach, Forestomach | + + |
__________________________________________________________________________|
Stomach, Glandular | + + |
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + |
Capsule, Hyperplasia, Focal | 1 |
Capsule, Hyperplasia, Multifocal | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + |
__________________________________________________________________________|
Islets, Pancreatic | A M |
__________________________________________________________________________|
Parathyroid Gland | + M |
__________________________________________________________________________|
Pituitary Gland | + + |
__________________________________________________________________________|
Thyroid Gland | + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 2| 6| 7| 7|
DAY ON TEST | 2| 3| 7| 3| 3| 3| 2| 3| 3| 1| 2| 7| 3| 0| 3| 6| 3| 3| 3| 2| 2| 4| 7| 2| 3|
| 9| 1| 9| 2| 0| 3| 8| 2| 0| 4| 9| 4| 0| 8| 2| 7| 2| 1| 2| 8| 9| 6| 4| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
3 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Epididymis | + + |
__________________________________________________________________________|
Penis | |
Concretion, Chronic Active, | |
Multifocal | |
Inflammation, Chronic Active, | |
Multifocal | |
__________________________________________________________________________|
Preputial Gland | + + |
Inflammation, Chronic Active, | |
Multifocal | 4 |
Duct, Dilatation, Focal | 4 |
__________________________________________________________________________|
Prostate | + + |
Inflammation, Chronic Active, | |
Multifocal | |
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | A + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + |
Depletion Lymphoid, Diffuse | 3 |
Hyperplasia, Lymphoid, Multifocal | 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + |
Hematopoietic Cell Proliferation, | |
Multifocal | 3 3 3 4 3 3 2 3 3 3 |
Inflammation, Multifocal, Suppurative| 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + A + + + + + + + + + + + + + + +|
Lymphoid Follicle, Depletion | |
Lymphoid, Multifocal | 3 |
Lymphoid Follicle, Necrosis, Acute, | |
Multifocal | |
Red Pulp, Fibrosis, Multifocal | 2 |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 2 2 3 2 2 2 2 2 2 3 3 3 2 2 2 2 2 2 2 3 3 2 2|
Red Pulp, Pigmentation, Hemosiderin, | |
Multifocal | 2 2 1 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 1 1 1 2|
__________________________________________________________________________|
Thymus | I M |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + |
Acanthosis, Diffuse | 3 3 2 |
Acanthosis, Focal | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 2| 6| 7| 7|
DAY ON TEST | 2| 3| 7| 3| 3| 3| 2| 3| 3| 1| 2| 7| 3| 0| 3| 6| 3| 3| 3| 2| 2| 4| 7| 2| 3|
| 9| 1| 9| 2| 0| 3| 8| 2| 0| 4| 9| 4| 0| 8| 2| 7| 2| 1| 2| 8| 9| 6| 4| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
3 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Acanthosis, Multifocal | 3 2 3 |
Inflammation, Chronic Active, | |
Multifocal | 2 |
Ulcer | 2 4 2 3 |
Sebaceous Gland, Hyperplasia, Focal | |
Subcutaneous Tissue, Fibrosis, | |
Diffuse | 2 |
Subcutaneous Tissue, Fibrosis, Focal | |
Subcutaneous Tissue, Fibrosis, | |
Multifocal | 2 |
Subcutaneous Tissue, Inflammation, | |
Acute, Multifocal | 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active, Diffuse | 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active, Focal | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active, Multifocal | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + +|
Bilateral, Joint, Tarsal, | |
Hyperostosis | 3 2 3 3 2 2 3 3 3 2 3 3|
Bilateral, Joint, Tarsal, Metaplasia,| |
Multifocal, Osseous | 2 2 2 2 2 2 2 2 2 2 2 2|
Joint, Tarsal, Hyperostosis | |
Joint, Tarsal, Metaplasia, | |
Multifocal, Osseous | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + |
Interstitium, Inflammation, Chronic | |
Active, Multifocal | |
__________________________________________________________________________|
Nose | + + |
__________________________________________________________________________|
Trachea | + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + M +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 2| 6| 7| 7|
DAY ON TEST | 2| 3| 7| 3| 3| 3| 2| 3| 3| 1| 2| 7| 3| 0| 3| 6| 3| 3| 3| 2| 2| 4| 7| 2| 3|
| 9| 1| 9| 2| 0| 3| 8| 2| 0| 4| 9| 4| 0| 8| 2| 7| 2| 1| 2| 8| 9| 6| 4| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
3 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Infarct, Chronic, Focal | |
Inflammation, Acute, Multifocal, | |
Suppurative | |
Mineralization, Focal | |
__________________________________________________________________________|
Urinary Bladder | + A + + + |
Dilatation, Diffuse | 4 4 4 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 2| 3| 3| 3| 2| 0| 2| 3| 0| 3| 3| 2| 2| 3| 7| 2| 3| 2| 6| 3| 2| 3| 2| 3| 3| |
| 8| 1| 0| 0| 9| 3| 9| 2| 3| 2| 1| 8| 9| 1| 5| 8| 1| 9| 7| 2| 8| 0| 9| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
3 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 5 |
__________________________________________________________________________|____________|
Gallbladder | A A A | |
__________________________________________________________________________|____________|
Intestine Large | + + + | 6 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + A | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 6 |
Inflammation, Acute, Multifocal, | | |
Necrotizing | | 1 3.0|
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + A | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + A | 4 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | I + A | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | M + A | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A | 4 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 |
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 2 | 4 2.0|
Inflammation | | 1 1.0|
Necrosis, Chronic Active, Multifocal | | 1 4.0|
Vacuolization Cytoplasmic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + A | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + | 5 |
__________________________________________________________________________|____________|
Stomach | + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 5 |
__________________________________________________________________________|____________|
Tooth | + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + | 5 |
Capsule, Hyperplasia, Focal | | 1 1.0|
Capsule, Hyperplasia, Multifocal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + | 5 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | I + + | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + A | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 4 |
__________________________________________________________________________|____________|
Pituitary Gland | + + M | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 2| 3| 3| 3| 2| 0| 2| 3| 0| 3| 3| 2| 2| 3| 7| 2| 3| 2| 6| 3| 2| 3| 2| 3| 3| |
| 8| 1| 0| 0| 9| 3| 9| 2| 3| 2| 1| 8| 9| 1| 5| 8| 1| 9| 7| 2| 8| 0| 9| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
3 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + | 5 |
__________________________________________________________________________|____________|
Penis | + | 1 |
Concretion, Chronic Active, | | |
Multifocal | 3 | 1 3.0|
Inflammation, Chronic Active, | | |
Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + | 3 |
Inflammation, Chronic Active, | | |
Multifocal | 4 | 2 4.0|
Duct, Dilatation, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + M | 4 |
Inflammation, Chronic Active, | | |
Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 1 |
__________________________________________________________________________|____________|
Testes | + + + | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + A | 3 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + | 25 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 8 |
Depletion Lymphoid, Diffuse | | 1 3.0|
Hyperplasia, Lymphoid, Multifocal | 3 | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + + M + + M | 19 |
Hematopoietic Cell Proliferation, | | |
Multifocal | 3 3 3 3 2 3 2 3 | 18 2.9|
Inflammation, Multifocal, Suppurative| | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + A +| 47 |
Lymphoid Follicle, Depletion | | |
Lymphoid, Multifocal | | 1 3.0|
Lymphoid Follicle, Necrosis, Acute, | | |
Multifocal | 3 | 1 3.0|
Red Pulp, Fibrosis, Multifocal | | 1 2.0|
Red Pulp, Hematopoietic Cell | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 2| 3| 3| 3| 2| 0| 2| 3| 0| 3| 3| 2| 2| 3| 7| 2| 3| 2| 6| 3| 2| 3| 2| 3| 3| |
| 8| 1| 0| 0| 9| 3| 9| 2| 3| 2| 1| 8| 9| 1| 5| 8| 1| 9| 7| 2| 8| 0| 9| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
3 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Proliferation, Diffuse | 2 2 3 2 3 3 2 3 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 47 2.2|
Red Pulp, Pigmentation, Hemosiderin, | | |
Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 1| 47 1.9|
__________________________________________________________________________|____________|
Thymus | M A M | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + M + + + + + + +| 27 |
Acanthosis, Diffuse | | 3 2.7|
Acanthosis, Focal | 3 3| 2 3.0|
Acanthosis, Multifocal | 3 | 4 2.8|
Inflammation, Chronic Active, | | |
Multifocal | | 1 2.0|
Ulcer | 3 2 3 3 2 | 9 2.7|
Sebaceous Gland, Hyperplasia, Focal | 2| 1 2.0|
Subcutaneous Tissue, Fibrosis, | | |
Diffuse | | 1 2.0|
Subcutaneous Tissue, Fibrosis, Focal | 3 2 | 2 2.5|
Subcutaneous Tissue, Fibrosis, | | |
Multifocal | 3 3 3 | 4 2.8|
Subcutaneous Tissue, Inflammation, | | |
Acute, Multifocal | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active, Diffuse | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active, Focal | 2 3 | 2 2.5|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active, Multifocal | 3 2 3 3 | 5 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + +| 28 |
Bilateral, Joint, Tarsal, | | |
Hyperostosis | 3 2 3 3 3 3 3 3 3| 21 2.8|
Bilateral, Joint, Tarsal, Metaplasia,| | |
Multifocal, Osseous | 2 2 2 2 2 2 2 2 2| 21 2.0|
Joint, Tarsal, Hyperostosis | 2 2 | 2 2.0|
Joint, Tarsal, Metaplasia, | | |
Multifocal, Osseous | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 2| 3| 3| 3| 2| 0| 2| 3| 0| 3| 3| 2| 2| 3| 7| 2| 3| 2| 6| 3| 2| 3| 2| 3| 3| |
| 8| 1| 0| 0| 9| 3| 9| 2| 3| 2| 1| 8| 9| 1| 5| 8| 1| 9| 7| 2| 8| 0| 9| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
3 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + +| 10 |
Interstitium, Inflammation, Chronic | | |
Active, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + | 5 |
__________________________________________________________________________|____________|
Trachea | + + + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + M | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 6 |
Infarct, Chronic, Focal | 3 | 1 3.0|
Inflammation, Acute, Multifocal, | | |
Suppurative | 3 3 4 | 3 3.3|
Mineralization, Focal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A A | 8 |
Dilatation, Diffuse | 4 3 4 3 | 7 3.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 9| 9| 3| 3| 2| 3| 3| 2| 2| 7| 3| 3| 2| 2| 2| 2| 2| 3| 2| 3| 2| 0| 3| 3|
| 1| 0| 9| 2| 0| 9| 1| 2| 9| 9| 4| 1| 1| 8| 8| 9| 9| 8| 2| 8| 2| 8| 0| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + A + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Crystals, Diffuse | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + M + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2|
Angiectasis, Multifocal | 3 |
Hematopoietic Cell Proliferation, | |
Diffuse | |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 |
Inflammation, Acute, Multifocal | 2 |
Inflammation, Chronic Active, | |
Multifocal | |
Necrosis, Acute, Multifocal | |
Necrosis, Chronic Active, Multifocal | 4 |
Thrombosis, Chronic | |
Centrilobular, Vacuolization | |
Cytoplasmic, Diffuse | 2 |
Kupffer Cell, Pigmentation, | |
Hemosiderin | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Multifocal | |
Acinus, Atrophy, Focal | 1 |
Acinus, Atrophy, Multifocal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Incisor, Dysplasia, Multifocal | 3 |
Molar, Dysplasia | |
Peridontal Tissue, Inflammation, | |
Chronic Active, Focal | 2 3 3 |
Peridontal Tissue, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 9| 9| 3| 3| 2| 3| 3| 2| 2| 7| 3| 3| 2| 2| 2| 2| 2| 3| 2| 3| 2| 0| 3| 3|
| 1| 0| 9| 2| 0| 9| 1| 2| 9| 9| 4| 1| 1| 8| 8| 9| 9| 8| 2| 8| 2| 8| 0| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Chronic Active, Multifocal | 3 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Coronary Artery, Inflammation, | |
Chronic Active, Focal | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia, Focal | |
Capsule, Hyperplasia, Multifocal | 2 2 2 2 2 2 2 3 2 2 2 3 3 2 2 2 3 2 2 2 3|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia, Focal | 2 2 3 |
Hyperplasia, Multifocal | 2 |
Hypertrophy, Focal | 2 2 2|
Necrosis, Acute, Focal | 2|
Vacuolization Cytoplasmic, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M M M M + + + + + + + + + + + + + + + + + + + M|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | M + + M M + I M + + + + + + + + + + + I + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Cyst, Multiple | X |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
Inflammation, Chronic, Multifocal | 2 |
Inflammation, Chronic Active, | |
Multifocal | 2 |
__________________________________________________________________________|
Preputial Gland | + + + |
Atrophy, Multifocal | 4 |
Inflammation, Chronic Active, | |
Multifocal | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Diffuse | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 9| 9| 3| 3| 2| 3| 3| 2| 2| 7| 3| 3| 2| 2| 2| 2| 2| 3| 2| 3| 2| 0| 3| 3|
| 1| 0| 9| 2| 0| 9| 1| 2| 9| 9| 4| 1| 1| 8| 8| 9| 9| 8| 2| 8| 2| 8| 0| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic Active, | |
Multifocal | |
Epithelium, Hyperplasia, Focal | |
__________________________________________________________________________|
Seminal Vesicle | + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration, | |
Chronic, Multifocal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Diffuse, Neutrophil | 4 3 |
Femoral, Angiectasis, Focal | 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hematopoietic Cell | |
Proliferation, Multifocal | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Multifocal, Plasma Cell | 3 3 |
Lymphocyte, Necrosis, Multifocal | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M M M M M M M M M M M M M M M + + + + M M +|
Hematocyst, Chronic Active | |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 3 2 2 2|
Hyperplasia, Lymphoid, Multifocal | 3 |
Inflammation, Chronic, Multifocal | |
__________________________________________________________________________|
Spleen | + + A + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Red Pulp, Angiectasis, Focal | 2 |
Red Pulp, Fibrosis, Multifocal | |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 2 2 3 2 2 2 2 2 3 2 3 3 2 3 2 2 2 3 2 3 3 2 2|
Red Pulp, Pigmentation, Hemosiderin, | |
Multifocal | 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 1 2 2 2|
__________________________________________________________________________|
Thymus | + + M M + + + + + + M + M M + + M M + I + M + + +|
Cyst, Multiple | |
Depletion Lymphoid, Multifocal | |
Necrosis, Acute, Multifocal | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Diffuse | 2 3 |
Acanthosis, Focal | 3 |
Acanthosis, Multifocal | 3 3 3 3 3 2|
Alopecia | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 9| 9| 3| 3| 2| 3| 3| 2| 2| 7| 3| 3| 2| 2| 2| 2| 2| 3| 2| 3| 2| 0| 3| 3|
| 1| 0| 9| 2| 0| 9| 1| 2| 9| 9| 4| 1| 1| 8| 8| 9| 9| 8| 2| 8| 2| 8| 0| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hyperkeratosis, Multifocal | 3 |
Parasite External | X X X X X X X |
Ulcer | 2 4 |
Ulcer, Multiple | 4 4 2|
Subcutaneous Tissue, Fibrosis, | |
Diffuse | 2 |
Subcutaneous Tissue, Fibrosis, Focal | 2 |
Subcutaneous Tissue, Fibrosis, | |
Multifocal | 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active, Focal | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active, Multifocal | 3 4 4 3 3 2|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Joint, Tarsal, | |
Hyperostosis | 2 3 3 2 |
Bilateral, Joint, Tarsal, Metaplasia,| |
Multifocal, Osseous | 2 2 2 2 |
Joint, Tarsal, Hyperostosis | 3 3 3 3 3 3 2 2|
Joint, Tarsal, Metaplasia, | |
Multifocal, Osseous | 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 3 2 |
Interstitium, Inflammation, Acute, | |
Diffuse | 2 |
Interstitium, Inflammation, Acute, | |
Multifocal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Respiratory Epithelium, Inflammation,| |
Acute, Multifocal | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 2 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 9| 9| 3| 3| 2| 3| 3| 2| 2| 7| 3| 3| 2| 2| 2| 2| 2| 3| 2| 3| 2| 0| 3| 3|
| 1| 0| 9| 2| 0| 9| 1| 2| 9| 9| 4| 1| 1| 8| 8| 9| 9| 8| 2| 8| 2| 8| 0| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Inflammation, Chronic, Multifocal | 4 |
__________________________________________________________________________|
Harderian Gland | M + M + + M + + + + + M + + + + + + + M M M + + +|
Acinus, Hyperplasia, Multifocal | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Nephropathy, Chronic, Focal | 3 |
Nephropathy, Chronic, Multifocal | 2 2 |
Cortex, Inflammation, Chronic, | |
Multifocal | 3 |
Perivascular, Infiltration Cellular, | |
Multifocal, Lymphocyte | |
Renal Tubule, Atypia Cellular, | |
Multifocal | 2 |
Renal Tubule, Degeneration, | |
Multifocal | 2 |
Renal Tubule, Pigmentation, | |
Hemosiderin, Multifocal | 2 2 3 |
Renal Tubule, Regeneration, | |
Multifocal | 2 2 1 1 2 2 1 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Submucosa, Necrosis, Acute, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 3| 6| 2| 2| 3| 3| 2| 2| 2| 0| 2| 9| 3| 8| 3| 2| 3| 8| 8| 3| 2| 8| 3| 2| |
| 8| 2| 7| 5| 8| 2| 0| 8| 4| 9| 2| 9| 0| 1| 2| 0| 2| 2| 8| 2| 2| 9| 2| 0| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
30 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + A + + + + + A + + + + + + + + + + + + + +| 47 |
Lumen, Crystals, Diffuse | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + M + A + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + A + + + A + A + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + A + A + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + A + A + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + A + A + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 2 | 2 2.0|
Angiectasis, Multifocal | 4 4 | 3 3.7|
Hematopoietic Cell Proliferation, | | |
Diffuse | 1 3 | 2 2.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 3 | 3 2.3|
Inflammation, Acute, Multifocal | | 1 2.0|
Inflammation, Chronic Active, | | |
Multifocal | 2 | 1 2.0|
Necrosis, Acute, Multifocal | 2 | 1 2.0|
Necrosis, Chronic Active, Multifocal | 4 4 4 3 4 | 6 3.8|
Thrombosis, Chronic | X X | 2 |
Centrilobular, Vacuolization | | |
Cytoplasmic, Diffuse | 2 2 2 | 4 2.0|
Kupffer Cell, Pigmentation, | | |
Hemosiderin | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 50 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic, Multifocal | 2 | 1 2.0|
Acinus, Atrophy, Focal | | 1 1.0|
Acinus, Atrophy, Multifocal | 2 2 2| 4 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + A + + + + + A + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + A + + + + + A + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + + + A + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 3| 6| 2| 2| 3| 3| 2| 2| 2| 0| 2| 9| 3| 8| 3| 2| 3| 8| 8| 3| 2| 8| 3| 2| |
| 8| 2| 7| 5| 8| 2| 0| 8| 4| 9| 2| 9| 0| 1| 2| 0| 2| 2| 8| 2| 2| 9| 2| 0| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
30 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Incisor, Dysplasia, Multifocal | | 1 3.0|
Molar, Dysplasia | 2 | 1 2.0|
Peridontal Tissue, Inflammation, | | |
Chronic Active, Focal | 3 | 4 2.8|
Peridontal Tissue, Inflammation, | | |
Chronic Active, Multifocal | | 3 2.7|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Coronary Artery, Inflammation, | | |
Chronic Active, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Capsule, Hyperplasia, Focal | 2 | 1 2.0|
Capsule, Hyperplasia, Multifocal | 2 2 2 2 1 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2| 44 2.1|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 2 |
Hyperplasia, Focal | 2 2 | 5 2.2|
Hyperplasia, Multifocal | | 1 2.0|
Hypertrophy, Focal | 2 2 2 2 2 2 2| 10 2.0|
Necrosis, Acute, Focal | | 1 2.0|
Vacuolization Cytoplasmic, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M + M + + M + M M M + + + + M| 38 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | I + M + + + + + + + + + + + + + + + + M + + + + +| 41 |
Pars Distalis, Cyst | X X | 2 |
Pars Distalis, Cyst, Multiple | | 1 |
Pars Distalis, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Multifocal, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 3| 6| 2| 2| 3| 3| 2| 2| 2| 0| 2| 9| 3| 8| 3| 2| 3| 8| 8| 3| 2| 8| 3| 2| |
| 8| 2| 7| 5| 8| 2| 0| 8| 4| 9| 2| 9| 0| 1| 2| 0| 2| 2| 8| 2| 2| 9| 2| 0| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
30 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Lymphocyte | 2 | 2 2.0|
Inflammation, Chronic, Multifocal | | 1 2.0|
Inflammation, Chronic Active, | | |
Multifocal | 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + | 5 |
Atrophy, Multifocal | | 1 4.0|
Inflammation, Chronic Active, | | |
Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute, Diffuse | 2 | 1 2.0|
Inflammation, Chronic Active, | | |
Multifocal | 3 | 1 3.0|
Epithelium, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 3 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Degeneration, | | |
Chronic, Multifocal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Diffuse, Neutrophil | 3 3 2 | 5 3.0|
Femoral, Angiectasis, Focal | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Mediastinal, Hematopoietic Cell | | |
Proliferation, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Hyperplasia, Multifocal, Plasma Cell | 3 | 3 3.0|
Lymphocyte, Necrosis, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + M M M M + M M + M + M + + M + M + M + M + M M| 17 |
Hematocyst, Chronic Active | 4 | 1 4.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 3 3 3 3 3 3 3 3 | 14 2.6|
Hyperplasia, Lymphoid, Multifocal | | 1 3.0|
Inflammation, Chronic, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis, Focal | 2 1 | 2 1.5|
Red Pulp, Angiectasis, Focal | | 1 2.0|
Red Pulp, Fibrosis, Multifocal | 2 | 1 2.0|
Red Pulp, Hematopoietic Cell | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 3| 6| 2| 2| 3| 3| 2| 2| 2| 0| 2| 9| 3| 8| 3| 2| 3| 8| 8| 3| 2| 8| 3| 2| |
| 8| 2| 7| 5| 8| 2| 0| 8| 4| 9| 2| 9| 0| 1| 2| 0| 2| 2| 8| 2| 2| 9| 2| 0| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
30 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Proliferation, Diffuse | 2 2 4 4 2 2 3 2 2 2 2 2 3 3 3 2 4 2 3 3 2 2 3 1 1| 48 2.4|
Red Pulp, Pigmentation, Hemosiderin, | | |
Multifocal | 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 48 1.9|
__________________________________________________________________________|____________|
Thymus | M M M M + M + + + + + I M M M + M + M M I + M + +| 27 |
Cyst, Multiple | X | 1 |
Depletion Lymphoid, Multifocal | 3 | 1 3.0|
Necrosis, Acute, Multifocal | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Acanthosis, Diffuse | 3 2| 4 2.5|
Acanthosis, Focal | | 1 3.0|
Acanthosis, Multifocal | 3 | 7 2.9|
Alopecia | 3 | 1 3.0|
Hyperkeratosis, Multifocal | | 1 3.0|
Parasite External | X X X X X | 12 |
Ulcer | 4 3 3| 5 3.2|
Ulcer, Multiple | 2 | 4 3.0|
Subcutaneous Tissue, Fibrosis, | | |
Diffuse | 2 3| 3 2.3|
Subcutaneous Tissue, Fibrosis, Focal | | 1 2.0|
Subcutaneous Tissue, Fibrosis, | | |
Multifocal | 3 | 2 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active, Focal | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active, Multifocal | 3 | 7 3.1|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Joint, Tarsal, | | |
Hyperostosis | 3 3 3 2 3 2 3 | 11 2.6|
Bilateral, Joint, Tarsal, Metaplasia,| | |
Multifocal, Osseous | 2 2 2 2 2 2 2 | 11 2.0|
Joint, Tarsal, Hyperostosis | 3 | 9 2.8|
Joint, Tarsal, Metaplasia, | | |
Multifocal, Osseous | 2 | 9 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 3| 6| 2| 2| 3| 3| 2| 2| 2| 0| 2| 9| 3| 8| 3| 2| 3| 8| 8| 3| 2| 8| 3| 2| |
| 8| 2| 7| 5| 8| 2| 0| 8| 4| 9| 2| 9| 0| 1| 2| 0| 2| 2| 8| 2| 2| 9| 2| 0| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
30 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia, | | |
Focal | 3 | 4 2.5|
Interstitium, Inflammation, Acute, | | |
Diffuse | | 1 2.0|
Interstitium, Inflammation, Acute, | | |
Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Respiratory Epithelium, Inflammation,| | |
Acute, Multifocal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Cataract | | 1 2.0|
Inflammation, Chronic, Multifocal | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + M M + + + M + +| 40 |
Acinus, Hyperplasia, Multifocal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Cyst | | 1 |
Nephropathy, Chronic, Focal | | 1 3.0|
Nephropathy, Chronic, Multifocal | 3 3 2 2 2| 7 2.3|
Cortex, Inflammation, Chronic, | | |
Multifocal | | 1 3.0|
Perivascular, Infiltration Cellular, | | |
Multifocal, Lymphocyte | 3 | 1 3.0|
Renal Tubule, Atypia Cellular, | | |
Multifocal | | 1 2.0|
Renal Tubule, Degeneration, | | |
Multifocal | | 1 2.0|
Renal Tubule, Pigmentation, | | |
Hemosiderin, Multifocal | 2 | 4 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 3| 6| 2| 2| 3| 3| 2| 2| 2| 0| 2| 9| 3| 8| 3| 2| 3| 8| 8| 3| 2| 8| 3| 2| |
| 8| 2| 7| 5| 8| 2| 0| 8| 4| 9| 2| 9| 0| 1| 2| 0| 2| 2| 8| 2| 2| 9| 2| 0| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
30 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Regeneration, | | |
Multifocal | 2 2 2 2 2 2 2 2 2 2 1 2 2 | 30 1.9|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Submucosa, Necrosis, Acute, | | |
Multifocal | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 3| 7| 6| 7| 7| 4| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 8| 3| 5| 2| 2| 4| 2| 6| 2| 2| 6| 8| 3| 3| 2| 3| 3| 8| 3| 1| 3| 3| 3| 3|
| 9| 9| 0| 5| 8| 8| 3| 9| 6| 6| 8| 7| 7| 1| 0| 9| 2| 0| 4| 2| 4| 1| 2| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + M |
__________________________________________________________________________|
Gallbladder | A A + + A + |
Necrosis, Acute, Multifocal | 3 |
Submucosa, Fibrosis, Diffuse | 3 |
__________________________________________________________________________|
Intestine Large | + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + A + + A |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + M |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition, Multifocal | 3 |
Cyst | |
Hematopoietic Cell Proliferation, | |
Focal | |
Hematopoietic Cell Proliferation, | |
Multifocal | 1 |
Inflammation, Chronic, Multifocal | 3 2 |
Necrosis, Chronic Active, Multifocal | 3 |
Necrosis, Coagulative, Focal | 4 |
Bile Duct, Hyperplasia, Multifocal | 3 |
Hepatocyte, Cytomegaly, Diffuse | |
Hepatocyte, Hyperplasia, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + |
__________________________________________________________________________|
Stomach | + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + |
__________________________________________________________________________|
Tooth | + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + |
Capsule, Hyperplasia, Multifocal | 3 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + |
__________________________________________________________________________|
Parathyroid Gland | M M M M + |
__________________________________________________________________________|
Pituitary Gland | I M + M + |
__________________________________________________________________________|
Thyroid Gland | + + + + + |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 3| 7| 6| 7| 7| 4| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 8| 3| 5| 2| 2| 4| 2| 6| 2| 2| 6| 8| 3| 3| 2| 3| 3| 8| 3| 1| 3| 3| 3| 3|
| 9| 9| 0| 5| 8| 8| 3| 9| 6| 6| 8| 7| 7| 1| 0| 9| 2| 0| 4| 2| 4| 1| 2| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + +|
Atrophy, Multifocal | 3 |
Inflammation, Chronic Active, | |
Multifocal | 3|
Inflammation, Multifocal, Suppurative| 3 |
Duct, Dilatation, Focal | 3 |
Duct, Dilatation, Multifocal | 4 3|
__________________________________________________________________________|
Prostate | + + + + + |
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Neutrophilia | X |
__________________________________________________________________________|
Bone Marrow | + + + + + |
Hyperplasia, Diffuse, Neutrophil | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + |
Hyperplasia, Lymphoid, Multifocal | 2 |
Hyperplasia, Multifocal, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | M M + + M + + + + M M + + +|
Angiectasis, Multifocal | |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 2 3 2 3 3 3 3 2|
Inflammation, Focal, Granulomatous | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + A + + + + + + + + + + + +|
Amyloid Deposition, Multifocal | 3 |
Angiectasis, Focal | 1 |
Angiectasis, Multifocal | 2 |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 2 4 2 3 2 2 3 1 3 2 3 4 2 2 2 2 2 2 2 2 3 3 2 2|
Red Pulp, Pigmentation, Hemosiderin, | |
Multifocal | 2 2 2 1 2 1 1 1 1 1 2 2 2 2 2 1 2 2 2 2 2 2|
__________________________________________________________________________|
Thymus | M M M + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + M + + + + + + |
Acanthosis, Diffuse | 3 3 3 |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 3| 7| 6| 7| 7| 4| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 8| 3| 5| 2| 2| 4| 2| 6| 2| 2| 6| 8| 3| 3| 2| 3| 3| 8| 3| 1| 3| 3| 3| 3|
| 9| 9| 0| 5| 8| 8| 3| 9| 6| 6| 8| 7| 7| 1| 0| 9| 2| 0| 4| 2| 4| 1| 2| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Acanthosis, Multifocal | 3 |
Ulcer | 3 3 4 3 |
Subcutaneous Tissue, Fibrosis, | |
Diffuse | 3 3 3 |
Subcutaneous Tissue, Fibrosis, Focal | |
Subcutaneous Tissue, Fibrosis, | |
Multifocal | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active, Diffuse | 4 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active, Multifocal | |
Subcutaneous Tissue, Inflammation, | |
Multifocal | |
Subcutaneous Tissue, Mineralization, | |
Multifocal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + |
Bilateral, Joint, Tarsal, | |
Hyperostosis | 3 2 2 3 3 3 3 3 3 3 |
Bilateral, Joint, Tarsal, Metaplasia,| |
Multifocal, Osseous | 2 2 2 2 2 2 2 2 2 2 |
Joint, Tarsal, Hyperostosis | 3 2 2 |
Joint, Tarsal, Metaplasia, | |
Multifocal, Osseous | 2 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
__________________________________________________________________________|
Nose | + + + + + |
Respiratory Epithelium, Inflammation,| |
Acute, Multifocal | |
__________________________________________________________________________|
Trachea | + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract, Multifocal | 4 |
Retina, Atrophy, Multifocal | 3 |
__________________________________________________________________________|
Harderian Gland | M + + M + + |
Inflammation, Chronic Active, | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
_____________________________________________________________________________________________________________________
| 7| 3| 7| 6| 7| 7| 4| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 8| 3| 5| 2| 2| 4| 2| 6| 2| 2| 6| 8| 3| 3| 2| 3| 3| 8| 3| 1| 3| 3| 3| 3|
| 9| 9| 0| 5| 8| 8| 3| 9| 6| 6| 8| 7| 7| 1| 0| 9| 2| 0| 4| 2| 4| 1| 2| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Multifocal | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + |
Amyloid Deposition, Multifocal | 3 |
Infarct, Chronic, Focal | |
Nephropathy, Chronic, Multifocal | 2 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + |
Dilatation | 4 |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 7| 6| 7| 6| 6| |
DAY ON TEST | 2| 3| 2| 6| 2| 1| 0| 3| 6| 0| 2| 3| 3| 7| 3| 2| 2| 7| 2| 2| 2| 8| 2| 6| 6| |
| 9| 1| 9| 7| 8| 1| 3| 1| 7| 3| 4| 0| 2| 4| 0| 3| 9| 4| 9| 9| 9| 7| 9| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
10 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 6 |
__________________________________________________________________________|____________|
Gallbladder | + A | 4 |
Necrosis, Acute, Multifocal | | 1 3.0|
Submucosa, Fibrosis, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + | 7 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A | 4 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 7 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A | 5 |
__________________________________________________________________________|____________|
Intestine Small | + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 6 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | M A | 3 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + | 8 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition, Multifocal | | 1 3.0|
Cyst | X | 1 |
Hematopoietic Cell Proliferation, | | |
Focal | 3 | 1 3.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 1 2 1 2 2 | 6 1.5|
Inflammation, Chronic, Multifocal | | 2 2.5|
Necrosis, Chronic Active, Multifocal | | 1 3.0|
Necrosis, Coagulative, Focal | | 1 4.0|
Bile Duct, Hyperplasia, Multifocal | 4 | 2 3.5|
Hepatocyte, Cytomegaly, Diffuse | 4 | 1 4.0|
Hepatocyte, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + | 7 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 7 |
__________________________________________________________________________|____________|
Stomach | + + | 7 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 7 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 7 |
__________________________________________________________________________|____________|
Tooth | + + | 7 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + | 8 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + | 7 |
Capsule, Hyperplasia, Multifocal | 1 1 | 4 1.8|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 7| 6| 7| 6| 6| |
DAY ON TEST | 2| 3| 2| 6| 2| 1| 0| 3| 6| 0| 2| 3| 3| 7| 3| 2| 2| 7| 2| 2| 2| 8| 2| 6| 6| |
| 9| 1| 9| 7| 8| 1| 3| 1| 7| 3| 4| 0| 2| 4| 0| 3| 9| 4| 9| 9| 9| 7| 9| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
10 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + | 7 |
__________________________________________________________________________|____________|
Islets, Pancreatic | M + | 6 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + | 4 |
__________________________________________________________________________|____________|
Thyroid Gland | + + | 7 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + | 7 |
__________________________________________________________________________|____________|
Penis | + + | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + | 5 |
Atrophy, Multifocal | | 1 3.0|
Inflammation, Chronic Active, | | |
Multifocal | | 1 3.0|
Inflammation, Multifocal, Suppurative| 4 | 2 3.5|
Duct, Dilatation, Focal | | 1 3.0|
Duct, Dilatation, Multifocal | | 2 3.5|
__________________________________________________________________________|____________|
Prostate | + + | 7 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 2 |
__________________________________________________________________________|____________|
Testes | + + | 7 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 2 |
Neutrophilia | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + | 7 |
Hyperplasia, Diffuse, Neutrophil | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + +| 28 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 9 |
Hyperplasia, Lymphoid, Multifocal | | 1 2.0|
Hyperplasia, Multifocal, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + M + + + +| 20 |
Angiectasis, Multifocal | 3 | 1 3.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 4 2 3 3 3 2 3 3| 18 2.7|
Inflammation, Focal, Granulomatous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Amyloid Deposition, Multifocal | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 7| 6| 7| 6| 6| |
DAY ON TEST | 2| 3| 2| 6| 2| 1| 0| 3| 6| 0| 2| 3| 3| 7| 3| 2| 2| 7| 2| 2| 2| 8| 2| 6| 6| |
| 9| 1| 9| 7| 8| 1| 3| 1| 7| 3| 4| 0| 2| 4| 0| 3| 9| 4| 9| 9| 9| 7| 9| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
10 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Angiectasis, Focal | | 1 1.0|
Angiectasis, Multifocal | | 1 2.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | 2 2 2 4 1 2 3 2 3 4 3 2 3 3 2 3 2 2 3 4 3 2 2 3 3| 49 2.5|
Red Pulp, Pigmentation, Hemosiderin, | | |
Multifocal | 2 2 2 1 1 2 1 1 2 2 1 1 2 1 2 2 2 1 2 2 2 2 2| 45 1.7|
__________________________________________________________________________|____________|
Thymus | + M | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + +| 28 |
Acanthosis, Diffuse | 3 2 | 5 2.8|
Acanthosis, Multifocal | 3 | 2 3.0|
Ulcer | 4 3 3 3 | 8 3.3|
Subcutaneous Tissue, Fibrosis, | | |
Diffuse | 3 | 4 3.0|
Subcutaneous Tissue, Fibrosis, Focal | 3 | 1 3.0|
Subcutaneous Tissue, Fibrosis, | | |
Multifocal | 4 | 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active, Diffuse | 4 | 2 4.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active, Multifocal | 3 | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Multifocal | 3 | 1 3.0|
Subcutaneous Tissue, Mineralization, | | |
Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 26 |
Bilateral, Joint, Tarsal, | | |
Hyperostosis | 3 2 2 2 2 3 | 16 2.6|
Bilateral, Joint, Tarsal, Metaplasia,| | |
Multifocal, Osseous | 2 2 2 2 2 2 | 16 2.0|
Joint, Tarsal, Hyperostosis | 2 | 4 2.3|
Joint, Tarsal, Metaplasia, | | |
Multifocal, Osseous | 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05020-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 14:10:51
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 7| 6| 7| 6| 6| |
DAY ON TEST | 2| 3| 2| 6| 2| 1| 0| 3| 6| 0| 2| 3| 3| 7| 3| 2| 2| 7| 2| 2| 2| 8| 2| 6| 6| |
| 9| 1| 9| 7| 8| 1| 3| 1| 7| 3| 4| 0| 2| 4| 0| 3| 9| 4| 9| 9| 9| 7| 9| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
10 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 7 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + | 14 |
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + | 7 |
Respiratory Epithelium, Inflammation,| | |
Acute, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + | 7 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Lens, Cataract, Multifocal | | 1 4.0|
Retina, Atrophy, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + | 7 |
Inflammation, Chronic Active, | | |
Multifocal | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + +| 10 |
Amyloid Deposition, Multifocal | | 1 3.0|
Infarct, Chronic, Focal | 4 | 1 4.0|
Nephropathy, Chronic, Multifocal | 3| 3 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 11 |
Dilatation | 3 3 4 | 4 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
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---------- END OF REPORT ----------
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