TR 351 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/03/94
EXP: 05020 PARA-CHLOROANILINE TIME: 20:08:06
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 02039B
CONT: NO1CP9565302 CAS: 106-47-8
PATHOLOGIST: R. PERSING
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/03/94
EXP: 05020 PARA-CHLOROANILINE TIME: 20:08:06
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 02039B
CONT: NO1CP9565302 CAS: 106-47-8
PATHOLOGIST: R. PERSING
PARA-CHLOROANILINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 7 CENSORED DEATHS 0 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 496 502 541 591 654 667 672 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 3 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 1 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 246 375 432 479 637 667 667 674 674 703 |
| 703 708 714 |
| CENSORED DEATHS |
| 133 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 389 423 443 511 514 526 584 655 666 666 |
| 667 667 667 667 674 674 687 687 703 703 |
| 724 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PARA-CHLOROANILINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 30 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 399 490 502 524 600 628 667 674 682 682 |
| 682 688 690 722 725 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PARA-CHLOROANILINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 728 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 100.0 100.0 94.0 92.0 90.0 86.0 |
| | |
| | |
|3 MG/KG | 100.0 100.0 98.0 98.0 95.9 91.8 91.8 91.8 89.8 73.5 |
| | |
| | |
|10 MG/KG | 100.0 100.0 100.0 100.0 96.0 94.0 88.0 86.0 84.0 58.0 |
| | |
| | |
|30 MG/KG | 100.0 100.0 100.0 100.0 98.0 98.0 92.0 90.0 88.0 70.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 3 MG/KG 10 MG/KG 30 MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 86.0% 73.5% 58.0% 70.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.295 P=0.211 P=0.005 P=0.110 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 589.0 590.7 614.1 623.7 |
|NATURAL DEATHS (C) | (29.2) (42.7) (22.3) (25.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 708.5 680.4 680.2 696.7 |
|(STANDARD ERROR) | ( 7.9) (17.7) (12.2) (10.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PARA-CHLOROANILINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 1 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 143 480 527 666 672 695 695 714 717 723 |
| CENSORED DEATHS |
| 1 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 3 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 5 CENSORED DEATHS 3 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 439 528 682 709 714 |
| CENSORED DEATHS |
| 1 1 2 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 6 CENSORED DEATHS 0 TERMINAL 44 |
| |
| UNCENSORED DEATHS |
| 521 532 625 667 672 679 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PARA-CHLOROANILINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 30 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 9 CENSORED DEATHS 0 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 458 550 609 616 637 667 702 704 722 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PARA-CHLOROANILINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 728 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 98.0 98.0 98.0 98.0 95.9 93.9 93.9 93.9 79.6 |
| | |
| | |
|3 MG/KG | 100.0 100.0 100.0 100.0 100.0 97.9 95.7 95.7 95.7 89.4 |
| | |
| | |
|10 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 96.0 94.0 88.0 |
| | |
| | |
|30 MG/KG | 100.0 100.0 100.0 100.0 100.0 98.0 98.0 96.0 90.0 82.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 3 MG/KG 10 MG/KG 30 MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 79.6% 89.4% 88.0% 82.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.875 P=0.298N P=0.408N P=0.966N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 603.2 614.4 616.0 629.4 |
|NATURAL DEATHS (C) | (57.5) (55.5) (29.4) (28.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 688.5 673.0 714.6 710.3 |
|(STANDARD ERROR) | (19.2) (25.2) ( 6.1) ( 7.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PARA-CHLOROANILINE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE = 1
3 MG/KG = 2
10 MG/KG = 3
30 MG/KG = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 34 1
|
| 2 2 34 3 411
| 2 32 3 4 1 1
95 +
| 2 3 2 43 4 1 1
| 33 4 14 1
| 2 2
90 + 3 3 4 42 1 1
|
P | 3 3 4 4
E | 3 3 12 1
R 85 +
C | 3 344
E |
N | 2 2
T 80 +
|
S | 44 22
U |
R 75 +
V | 4 2 2
I | 33
V |
A 70 + 4
L |
| 3 3
|
65 +
| 3 3
|
|
60 + 3 3
|
| 3
|
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 9 obs hidden.
PARA-CHLOROANILINE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE = 1
3 MG/KG = 2
10 MG/KG = 3
30 MG/KG = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100.0 +1 1 2 4 3
|
|
| 1 2 4 1 32 4
97.5 +
|
| 3 4 4 3
| 1 1 2
95.0 +
|
P | 1 44 3 1 2 2
E |
R 92.5 +
C | 4 4
E |
N |
T 90.0 + 4 13 1
| 2 2
S |
U | 43 4 3
R 87.5 +
V |
I |
V | 1 1
A 85.0 +
L |
| 4114
|
82.5 +
| 11
|
|
80.0 +
| 1
|
|
77.5 +
|
-+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 9 obs hidden.