TR 351 Rat Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
PARA-CHLOROANILINE
NTP Experiment-Test: 05020-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/03/94
Route: GAVAGE Time: 18:08:59
Facility: Battelle Columbus Laboratory
Chemical CAS #: 000106478
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05020-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 18:08:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 2 MG/KG 6 MG/KG 18 MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Dead 15 5 11 8
Moribund 8 6 3 5
Survivors
Terminal Sacrifice 27 39 36 37
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (40) (4) (3) (46)
Intestine Large, Colon (47) (6) (8) (46)
Intestine Small, Duodenum (49) (3) (8) (48)
Adenocarcinoma, Metastatic, Uterus 1 (2%)
Intestine Small, Ileum (40) (3) (2) (45)
Liver (50) (50) (50) (50)
Neoplastic Nodule 1 (2%) 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%)
Artery, Adenocarcinoma, Metastatic, Uterus 1 (2%)
Mesentery (49) (7) (11) (47)
Adenocarcinoma, Metastatic, Uterus 1 (2%) 1 (2%)
Lipoma 1 (9%)
Pancreas (50) (6) (12) (49)
Adenocarcinoma, Metastatic, Uterus 1 (2%) 1 (2%)
Salivary Glands (50) (8) (12) (49)
Carcinoma, Metastatic, Zymbal's Gland 1 (13%)
Stomach, Forestomach (50) (5) (9) (48)
Stomach, Glandular (50) (4) (9) (48)
Adenocarcinoma, Metastatic, Uterus 1 (2%)
Tongue (3) (1)
Squamous Cell Papilloma 2 (67%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (7) (10) (50)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05020-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 18:08:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 2 MG/KG 6 MG/KG 18 MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50) (50)
Adenoma 1 (2%)
Capsule, Adenocarcinoma, Metastatic, Uterus 1 (2%)
Adrenal Gland, Medulla (50) (50) (50) (50)
Pheochromocytoma Benign 2 (4%) 3 (6%) 1 (2%) 6 (12%)
Islets, Pancreatic (50) (5) (9) (48)
Adenoma 1 (2%) 1 (2%)
Pituitary Gland (50) (33) (35) (50)
Pars Distalis, Adenoma 20 (40%) 13 (39%) 17 (49%) 20 (40%)
Pars Distalis, Adenoma, Multiple 1 (2%) 3 (6%)
Pars Distalis, Carcinoma 1 (2%)
Thyroid Gland (49) (6) (11) (48)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 4 (8%) 1 (9%) 5 (10%)
C-Cell, Carcinoma 1 (2%) 1 (9%) 1 (2%)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (45) (5) (11) (48)
Adenoma 1 (2%) 1 (20%) 1 (9%) 4 (8%)
Ovary (50) (15) (15) (49)
Granulosa-Theca Tumor Benign 2 (13%)
Bilateral, Adenocarcinoma, Metastatic, Uterus 1 (2%)
Uterus (50) (14) (20) (50)
Adenocarcinoma 1 (2%) 1 (7%) 1 (2%)
Fibroma 1 (2%)
Polyp Stromal 4 (8%) 6 (43%) 7 (35%) 6 (12%)
Polyp Stromal, Multiple 1 (2%)
Vagina (1)
Polyp 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (32) (45) (37) (43)
Bone Marrow (50) (48) (50) (47)
Lymph Node (50) (12) (17) (50)
Mediastinal, Adenocarcinoma, Metastatic,
Uterus 1 (2%) 1 (2%)
Page 3
NTP Experiment-Test: 05020-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 18:08:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 2 MG/KG 6 MG/KG 18 MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Mediastinal, Sarcoma, Metastatic, Skin 1 (2%)
Lymph Node, Mandibular (49) (7) (14) (49)
Lymph Node, Mesenteric (7) (4) (1) (9)
Spleen (50) (50) (50) (50)
Adenocarcinoma, Metastatic, Uterus 1 (2%) 1 (2%)
Fibrosarcoma 1 (2%)
Osteosarcoma 1 (2%)
Thymus (42) (8) (11) (44)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (17) (22) (50)
Adenoma 1 (2%) 1 (6%) 3 (6%)
Fibroadenoma 6 (12%) 8 (47%) 12 (55%) 6 (12%)
Fibroadenoma, Multiple 2 (4%) 2 (12%) 1 (5%)
Sarcoma, Metastatic, Skin 1 (2%)
Skin (50) (20) (21) (50)
Basosquamous Tumor Benign 1 (2%)
Subcutaneous Tissue, Fibroma 2 (4%) 2 (10%) 2 (4%)
Subcutaneous Tissue, Fibrosarcoma 1 (5%)
Subcutaneous Tissue, Neurofibroma 1 (5%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (49) (5) (10) (50)
Sarcoma, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (5) (10) (50)
Astrocytoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (5) (11) (50)
Adenocarcinoma, Metastatic, Uterus 1 (2%) 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%)
Nose (49) (4) (11) (49)
Osteosarcoma 1 (9%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05020-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 18:08:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 2 MG/KG 6 MG/KG 18 MG/KG
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (2)
Carcinoma 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Adenocarcinoma, Metastatic, Uterus 1 (2%) 1 (2%)
Lipoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Leukemia Mononuclear 10 (20%) 2 (4%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05020-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 18:08:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 2 MG/KG 6 MG/KG 18 MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 37 30 34 40
Total Primary Neoplasms 63 48 46 65
Total Animals with Benign Neoplasms 32 27 31 36
Total Benign Neoplasms 51 42 42 59
Total Animals with Malignant Neoplasms 10 6 4 6
Total Malignant Neoplasms 12 6 4 6
Total Animals with Metastatic Neoplasms 1 1 2
Total Metastatic Neoplasm 11 1 11
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05020-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 18:08:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 2 MG/KG 6 MG/KG 18 MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 49 50 50 50
Early Deaths
Dead 5 5 9 17
Dosing Accident 2 1
Moribund 26 13 7 11
Survivors
Dead 1
Terminal Sacrifice 18 32 32 20
Animals Examined Microscopically 49 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (46) (5) (6) (44)
Colon, Rectum, Osteosarcoma, Metastatic,
Spleen 1 (2%)
Intestine Large, Rectum (47) (5) (8) (44)
Intestine Small, Duodenum (48) (5) (10) (46)
Fibrosarcoma, Metastatic, Spleen 2 (4%)
Osteosarcoma, Metastatic, Spleen 3 (7%)
Ileum, Jejunum, Osteosarcoma, Metastatic,
Spleen 1 (2%)
Intestine Small, Jejunum (46) (6) (8) (41)
Adenocarcinoma 1 (17%)
Osteosarcoma, Metastatic, Spleen 1 (2%)
Polyp Adenomatous 1 (13%)
Liver (49) (50) (49) (49)
Fibrosarcoma, Metastatic, Spleen 4 (8%)
Hepatocellular Carcinoma 1 (2%) 1 (2%) 1 (2%)
Hepatocellular Carcinoma, Multiple 1 (2%)
Neoplastic Nodule 5 (10%) 3 (6%)
Osteosarcoma, Metastatic, Spleen 8 (16%)
Mesentery (47) (11) (11) (48)
Fibrosarcoma, Metastatic, Spleen 1 (9%) 9 (19%)
Osteosarcoma, Metastatic, Spleen 11 (23%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Gland 1 (9%)
Sarcoma 1 (9%)
Pancreas (48) (8) (14) (47)
Fibrosarcoma, Metastatic, Spleen 1 (7%) 6 (13%)
Osteosarcoma, Metastatic, Spleen 10 (21%)
Acinus, Adenoma 1 (2%)
Salivary Glands (49) (6) (11) (49)
Stomach, Forestomach (47) (6) (11) (46)
Page 7
NTP Experiment-Test: 05020-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 18:08:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 2 MG/KG 6 MG/KG 18 MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Osteosarcoma, Metastatic, Spleen 1 (2%)
Glandular, Osteosarcoma, Metastatic, Spleen 1 (2%)
Stomach, Glandular (48) (6) (11) (45)
Fibrosarcoma, Metastatic, Spleen 1 (2%)
Osteosarcoma, Metastatic, Spleen 1 (2%)
Tongue (2) (1) (1)
Squamous Cell Papilloma 2 (100%) 1 (100%) 1 (100%)
Tooth (49) (5) (10) (49)
Gingiva, Squamous Cell Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (49) (8) (12) (50)
Pulmonary Artery, Fibrosarcoma, Metastatic,
Spleen 1 (2%)
Heart (49) (18) (23) (50)
Osteosarcoma, Metastatic, Bone 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (49) (50) (49) (49)
Adenoma 1 (2%)
Capsule, Fibrosarcoma, Metastatic, Spleen 1 (2%)
Capsule, Osteosarcoma, Metastatic, Spleen 1 (2%)
Medulla, Fibrosarcoma, Metastatic, Spleen 1 (2%)
Adrenal Gland, Medulla (49) (49) (48) (48)
Osteosarcoma, Metastatic, Bone 1 (2%)
Pheochromocytoma Malignant 1 (2%) 1 (2%) 1 (2%)
Pheochromocytoma Benign 10 (20%) 12 (24%) 9 (19%) 13 (27%)
Bilateral, Pheochromocytoma Benign 3 (6%) 2 (4%) 5 (10%) 12 (25%)
Islets, Pancreatic (48) (4) (10) (46)
Adenoma 3 (6%) 1 (2%)
Carcinoma 1 (2%)
Fibrosarcoma, Metastatic, Spleen 4 (9%)
Osteosarcoma, Metastatic, Spleen 7 (15%)
Parathyroid Gland (48) (7) (10) (45)
Adenoma 1 (14%) 1 (2%)
Pituitary Gland (47) (18) (19) (46)
Pars Distalis, Adenoma 19 (40%) 13 (72%) 11 (58%) 10 (22%)
Pars Distalis, Adenoma, Multiple 1 (2%) 1 (2%)
Pars Distalis, Carcinoma 1 (5%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (48) (8) (10) (45)
C-Cell, Adenoma 8 (17%) 2 (25%) 9 (20%)
C-Cell, Adenoma, Multiple 1 (2%)
Page 8
NTP Experiment-Test: 05020-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 18:08:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 2 MG/KG 6 MG/KG 18 MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
C-Cell, Carcinoma 1 (2%) 1 (13%) 1 (2%)
Follicular Cell, Adenocarcinoma 1 (13%)
Follicular Cell, Adenoma 1 (13%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Osteosarcoma, Metastatic, Spleen 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (20) (26) (50)
Fibrosarcoma, Metastatic, Spleen 2 (4%)
Osteosarcoma, Metastatic, Spleen 3 (6%)
Sarcoma 1 (2%)
Bilateral, Osteosarcoma, Metastatic, Spleen 1 (2%)
Penis (1)
Preputial Gland (46) (12) (15) (48)
Adenocarcinoma 1 (2%)
Adenoma 1 (2%) 7 (58%) 4 (27%) 2 (4%)
Prostate (49) (6) (13) (48)
Fibrosarcoma, Metastatic, Spleen 1 (2%)
Osteosarcoma, Metastatic, Spleen 3 (6%)
Seminal Vesicle (36) (3) (5) (23)
Osteosarcoma, Metastatic, Spleen 2 (9%)
Testes (49) (46) (50) (50)
Osteosarcoma, Metastatic, Spleen 3 (6%)
Bilateral, Interstitial Cell, Adenoma 25 (51%) 38 (83%) 33 (66%) 40 (80%)
Interstitial Cell, Adenoma 11 (22%) 6 (13%) 11 (22%) 6 (12%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (44) (45) (39) (31)
Bone Marrow (49) (50) (49) (50)
Osteosarcoma, Metastatic, Spleen 1 (2%)
Lymph Node (49) (16) (15) (49)
Mediastinal, Fibrosarcoma, Metastatic, Spleen 2 (4%)
Mediastinal, Osteosarcoma, Metastatic, Spleen 6 (12%)
Mediastinal, Pancreatic, Fibrosarcoma,
Metastatic, Spleen 1 (2%)
Lymph Node, Mandibular (48) (7) (12) (48)
Lymph Node, Mesenteric (10) (5) (2) (10)
Mediastinal, Osteosarcoma, Metastatic, Spleen 1 (10%)
Pancreatic, Fibrosarcoma, Metastatic, Spleen 1 (10%)
Page 9
NTP Experiment-Test: 05020-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 18:08:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 2 MG/KG 6 MG/KG 18 MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Spleen (49) (50) (50) (50)
Fibroma 2 (4%)
Fibrosarcoma 1 (2%) 2 (4%) 17 (34%)
Hemangiosarcoma 4 (8%)
Osteosarcoma 1 (2%) 19 (38%)
Thymus (43) (5) (13) (36)
Osteosarcoma, Metastatic, Spleen 1 (3%)
Thymoma Benign 1 (20%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (32) (6) (13) (36)
Fibroadenoma 1 (3%) 2 (33%) 3 (23%) 3 (8%)
Skin (47) (18) (19) (49)
Basal Cell Adenoma 1 (6%)
Basosquamous Tumor Benign 1 (2%) 1 (6%)
Keratoacanthoma 2 (4%) 1 (6%) 1 (5%) 1 (2%)
Squamous Cell Carcinoma 1 (6%)
Squamous Cell Papilloma 1 (5%)
Sebaceous Gland, Adenoma 1 (5%)
Subcutaneous Tissue, Fibroma 3 (6%) 2 (11%) 1 (5%) 4 (8%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 2 (11%) 1 (5%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (48) (50) (49) (50)
Cranium, Osteosarcoma 1 (2%)
Rib, Osteosarcoma 1 (2%)
Skeletal Muscle (47) (6) (11) (50)
Osteosarcoma, Metastatic, Bone 1 (2%) 1 (17%)
Osteosarcoma, Metastatic, Spleen 2 (4%)
Diaphragm, Fibrosarcoma, Metastatic, Spleen 3 (6%)
Diaphragm, Osteosarcoma, Metastatic, Spleen 2 (4%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (5) (10) (50)
Astrocytoma Benign 1 (2%)
Ependymoma Malignant 1 (2%)
Cerebellum, Meningioma Malignant 1 (10%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 05020-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 18:08:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 2 MG/KG 6 MG/KG 18 MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (7) (11) (50)
Alveolar/Bronchiolar Adenoma 1 (2%)
Fibrosarcoma, Metastatic, Spleen 5 (10%)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (14%)
Osteosarcoma, Metastatic, Spleen 3 (6%)
Squamous Cell Carcinoma 1 (9%)
Nose (48) (5) (10) (46)
Polyp 1 (2%)
Nasolacrimal Duct, Squamous Cell Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (7) (11) (13) (14)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (48) (50) (49) (50)
Fibrosarcoma, Metastatic, Spleen 1 (2%) 3 (6%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Osteosarcoma, Metastatic, Spleen 6 (12%)
Renal Tubule, Adenoma 1 (2%)
Ureter (47) (24) (27) (44)
Urethra (21) (3) (1) (11)
Urinary Bladder (47) (7) (12) (46)
Fibrosarcoma, Metastatic, Spleen 2 (4%)
Osteosarcoma, Metastatic, Spleen 1 (2%)
Papilloma 1 (8%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(49) *(50) *(50) *(50)
Leukemia Mononuclear 21 (43%) 3 (6%) 2 (4%) 3 (6%)
Mesothelioma Malignant 1 (2%) 3 (6%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 05020-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 18:08:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 2 MG/KG 6 MG/KG 18 MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 46 49 49 49
Total Primary Neoplasms 125 112 98 159
Total Animals with Benign Neoplasms 44 49 47 47
Total Benign Neoplasms 97 96 85 107
Total Animals with Malignant Neoplasms 28 14 12 43
Total Malignant Neoplasms 28 16 13 52
Total Animals with Metastatic Neoplasms 1 1 2 23
Total Metastatic Neoplasm 2 4 4 132
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 12
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