TR 351 Rat Pathology Tables
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
Facility: Battelle Columbus Laboratory
Chemical CAS #: 000106478
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 5| 5| 7| 1| 6| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 2| 7| 7|
DAY ON TEST | 1| 5| 3| 8| 1| 3| 3| 3| 8| 3| 3| 3| 2| 2| 3| 3| 2| 3| 3| 1| 6| 3| 0| 0| 2|
| 9| 7| 2| 9| 8| 1| 0| 2| 2| 1| 0| 7| 8| 9| 1| 7| 9| 0| 2| 4| 9| 1| 0| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 4 4 4 3|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + A A + + + + + + + A + + + M|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + A|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + A A + + + + + + + + + + + M|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + A + + A M + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + A A + + + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X|
Degeneration, Fatty | 4 |
Fibrosis | 2 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic | 1 2 1 2 2 1 1 2 3 1 1 3 1|
Inflammation, Necrotizing | 2 |
Vacuolization Cytoplasmic | 2 |
Bile Duct, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 2 1 1 1 2 |
__________________________________________________________________________|
Pharynx | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Hyperkeratosis | 2 |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Necrosis, Coagulative | |
__________________________________________________________________________|
Tongue | + + |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 5| 5| 7| 1| 6| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 2| 7| 7|
DAY ON TEST | 1| 5| 3| 8| 1| 3| 3| 3| 8| 3| 3| 3| 2| 2| 3| 3| 2| 3| 3| 1| 6| 3| 0| 0| 2|
| 9| 7| 2| 9| 8| 1| 0| 2| 2| 1| 0| 7| 8| 9| 1| 7| 9| 0| 2| 4| 9| 1| 0| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1|
Coronary Artery, Inflammation, | |
Chronic Active | |
Valve, Inflammation, Chronic Active | 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Degeneration, Fatty | 3 2 |
Hyperplasia | 2 1 2 2 2 2 |
Hypertrophy | |
Necrosis | 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + M + + M + + + + M + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 2 2 2 1 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Cyst | X |
C-Cell, Hyperplasia | 1 1 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia | 2 |
Inflammation, Chronic Active | 1 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 4 |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 3 1 1 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + |
Lymphopenia | X |
Neutropenia | X |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 5| 5| 7| 1| 6| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 2| 7| 7|
DAY ON TEST | 1| 5| 3| 8| 1| 3| 3| 3| 8| 3| 3| 3| 2| 2| 3| 3| 2| 3| 3| 1| 6| 3| 0| 0| 2|
| 9| 7| 2| 9| 8| 1| 0| 2| 2| 1| 0| 7| 8| 9| 1| 7| 9| 0| 2| 4| 9| 1| 0| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Neutrophilia | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Atrophy | 4 |
Femoral, Hyperplasia | 3 3 4 3 2 3 |
Femoral, Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Necrosis | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + + +|
Hemorrhage | |
Hyperplasia, Plasma Cell | 2 |
Infiltration Cellular, Histiocyte | 2 |
Necrosis | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + +|
Edema | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | |
Necrosis | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 1 2 2 2 2 4 1 2 2 2 2 2 2 2 2 2|
Necrosis | 4 |
Pigmentation, Hemosiderin | 2 2 2 2 2 2 2 2 1 2 1 2 2 2 2 2 2 1|
__________________________________________________________________________|
Thymus | + + M + + + + M + + + M M + + + + M + + + + + + +|
Depletion Lymphoid | 4 |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia, Cystic | 2 3 2 2 2 2 3 2 2 3 2 2 3 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Hydrocephalus | 2 |
Thrombosis | |
__________________________________________________________________________|
Peripheral Nerve | + |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 5| 5| 7| 1| 6| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 2| 7| 7|
DAY ON TEST | 1| 5| 3| 8| 1| 3| 3| 3| 8| 3| 3| 3| 2| 2| 3| 3| 2| 3| 3| 1| 6| 3| 0| 0| 2|
| 9| 7| 2| 9| 8| 1| 0| 2| 2| 1| 0| 7| 8| 9| 1| 7| 9| 0| 2| 4| 9| 1| 0| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | 2 |
Inflammation, Chronic Active | 4 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Mediastinum, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Inflammation, Chronic Active | 3 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + |
Inflammation, Chronic | 4 |
Lens, Cataract | 3 3 3 3 3 |
Retina, Atrophy | 3 3 3 3 3 |
__________________________________________________________________________|
Harderian Gland | + + + + M + + + M + + M + M + + + + + + M + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 2 2 2 2 2 2 1 1 1 1 1 2 1 1 1 2 1 2 1|
Renal Tubule, Pigmentation, | |
Hemosiderin | 1 1 1 1 1 1 1 1 2 2 2 1 1 1 1 1 1 1 1 2 2 1|
__________________________________________________________________________|
Ureter | + + + + + + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 2| 0| 7| 7| |
DAY ON TEST | 3| 0| 2| 6| 3| 1| 3| 2| 4| 2| 3| 3| 3| 3| 2| 0| 3| 3| 3| 5| 3| 0| 8| 3| 3| |
| 0| 5| 9| 2| 1| 2| 0| 9| 4| 9| 0| 2| 2| 2| 9| 0| 2| 0| 2| 8| 2| 9| 0| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 4 4 | 6 3.8|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + A + + + + + + A + + + A + A + + +| 40 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +| 47 |
Parasite Metazoan | X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + A + + + + +| 45 |
Parasite Metazoan | X X X | 3 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + A + + + + + + + + + A + + + A + A + + +| 40 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + A + A + + +| 43 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X| 38 |
Degeneration, Fatty | | 1 4.0|
Fibrosis | | 1 2.0|
Hepatodiaphragmatic Nodule | X X X X| 5 |
Inflammation, Chronic | 1 1 2 2 2 3 3 2 1 1 2 2 1 2 1 2 1 2 2| 32 1.7|
Inflammation, Necrotizing | | 1 2.0|
Vacuolization Cytoplasmic | 3 2 | 3 2.3|
Bile Duct, Hyperplasia | 1 1 1 1 1| 8 1.4|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 2 1 1 2 1 | 13 1.5|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | | 1 3.0|
Hyperkeratosis | | 1 2.0|
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
Necrosis, Coagulative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + | 3 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 2| 0| 7| 7| |
DAY ON TEST | 3| 0| 2| 6| 3| 1| 3| 2| 4| 2| 3| 3| 3| 3| 2| 0| 3| 3| 3| 5| 3| 0| 8| 3| 3| |
| 0| 5| 9| 2| 1| 2| 0| 9| 4| 9| 0| 2| 2| 2| 9| 0| 2| 0| 2| 8| 2| 9| 0| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 2 2 2 2 2 1 2 2 1 2 1 2 1 2 2 2 2 | 32 1.8|
Coronary Artery, Inflammation, | | |
Chronic Active | 4 | 1 4.0|
Valve, Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 2.5|
Degeneration, Fatty | 2 2 | 4 2.3|
Hyperplasia | 2 1 2 1 2 2 1| 13 1.7|
Hypertrophy | 1 | 1 1.0|
Necrosis | 3 | 3 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 4 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + + + + M + + + + + M + + +| 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | | 2 2.0|
Pars Distalis, Cyst | | 2 |
Pars Distalis, Hyperplasia | 2 2 2 2 3 2 2 | 17 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 |
C-Cell, Hyperplasia | 2 1 2 1 1 2 2 1 1 2 1 2 2| 25 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + + M + + + + + + + + + + + + + M + + + + M +| 45 |
Hyperplasia | 2 | 2 2.0|
Inflammation, Chronic Active | 1 2 1 1 1 1| 8 1.1|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 2| 0| 7| 7| |
DAY ON TEST | 3| 0| 2| 6| 3| 1| 3| 2| 4| 2| 3| 3| 3| 3| 2| 0| 3| 3| 3| 5| 3| 0| 8| 3| 3| |
| 0| 5| 9| 2| 1| 2| 0| 9| 4| 9| 0| 2| 2| 2| 9| 0| 2| 0| 2| 8| 2| 9| 0| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Oviduct | + M + + + M M + M + + + + + + + + + + + + + + +| 38 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | | 2 3.5|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 1 2 1 2 | 9 1.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + +| 32 |
Lymphopenia | | 1 |
Neutropenia | | 1 |
Neutrophilia | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Atrophy | | 1 4.0|
Femoral, Hyperplasia | 3 2 2 2 4 | 11 2.8|
Femoral, Hyperplasia, Reticulum Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Plasma Cell | | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 7 |
Edema | 2 2 | 2 2.0|
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Lymphoid | | 1 2.0|
Fibrosis | | 1 3.0|
Hematopoietic Cell Proliferation | 2 2 2 3 1 2 2 2 2 1 2 2 2 1 3 1 2 2 2 2| 41 2.0|
Necrosis | | 1 4.0|
Pigmentation, Hemosiderin | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2| 39 1.9|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M M + + + + + + + + M + + + + +| 42 |
Depletion Lymphoid | | 1 4.0|
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 2| 0| 7| 7| |
DAY ON TEST | 3| 0| 2| 6| 3| 1| 3| 2| 4| 2| 3| 3| 3| 3| 2| 0| 3| 3| 3| 5| 3| 0| 8| 3| 3| |
| 0| 5| 9| 2| 1| 2| 0| 9| 4| 9| 0| 2| 2| 2| 9| 0| 2| 0| 2| 8| 2| 9| 0| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Cystic | 3 2 4 3 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 3| 34 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X X | 4 |
Hydrocephalus | 2 2 | 3 2.0|
Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + | 3 |
__________________________________________________________________________|____________|
Spinal Cord | + + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage, Acute | | 1 2.0|
Inflammation, Chronic Active | 2 2 1 | 5 2.2|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Mediastinum, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | | 1 2.0|
Inflammation, Chronic Active | 2 | 3 2.3|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + | 12 |
Inflammation, Chronic | | 1 4.0|
Lens, Cataract | 3 3 3 3 3 | 10 3.0|
Retina, Atrophy | 3 3 3 2 3 3 | 11 2.9|
__________________________________________________________________________|____________|
Harderian Gland | + + + + M + + + M M + + + + + + + + + + + + + + +| 42 |
Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 2| 0| 7| 7| |
DAY ON TEST | 3| 0| 2| 6| 3| 1| 3| 2| 4| 2| 3| 3| 3| 3| 2| 0| 3| 3| 3| 5| 3| 0| 8| 3| 3| |
| 0| 5| 9| 2| 1| 2| 0| 9| 4| 9| 0| 2| 2| 2| 9| 0| 2| 0| 2| 8| 2| 9| 0| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 2 2 2 2 1 1 1 1 2 1 1 2 2 3 2 1 2 2 3| 39 1.6|
Renal Tubule, Pigmentation, | | |
Hemosiderin | 1 1 1 2 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1| 44 1.2|
__________________________________________________________________________|____________|
Ureter | + + + + +| 17 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 1| 7| 7|
DAY ON TEST | 2| 2| 3| 0| 3| 3| 3| 2| 6| 2| 2| 3| 3| 3| 3| 3| 3| 3| 8| 2| 3| 2| 4| 1| 3|
| 9| 9| 1| 5| 2| 0| 0| 3| 4| 9| 9| 0| 2| 1| 1| 0| 2| 1| 8| 9| 1| 9| 0| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + |
Foreign Body | |
__________________________________________________________________________|
Intestine Large | + + |
__________________________________________________________________________|
Intestine Large, Cecum | + M |
Inflammation, Chronic Active | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + |
__________________________________________________________________________|
Intestine Large, Rectum | + M |
__________________________________________________________________________|
Intestine Small | + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + M |
__________________________________________________________________________|
Intestine Small, Ileum | + M |
__________________________________________________________________________|
Intestine Small, Jejunum | + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Degeneration, Cystic | 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic | 2 2 2 1 1 1 2 2 1 1 1 2 2 1 1 2 1|
Inflammation, Necrotizing | |
Vacuolization Cytoplasmic | 2 |
Bile Duct, Hyperplasia | 1 1 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic | 3 |
Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + |
__________________________________________________________________________|
Stomach | + + |
__________________________________________________________________________|
Stomach, Forestomach | + + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + |
Necrosis, Coagulative | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + |
__________________________________________________________________________|
Heart | + + + |
Cardiomyopathy, Chronic | 2 |
Coronary Artery, Inflammation, | |
Chronic Active | |
Endocardium, Proliferation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 1| 7| 7|
DAY ON TEST | 2| 2| 3| 0| 3| 3| 3| 2| 6| 2| 2| 3| 3| 3| 3| 3| 3| 3| 8| 2| 3| 2| 4| 1| 3|
| 9| 9| 1| 5| 2| 0| 0| 3| 4| 9| 9| 0| 2| 1| 1| 0| 2| 1| 8| 9| 1| 9| 0| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Degeneration, Fatty | 2 1 1 2 2 |
Hyperplasia | 2 2 2 2 2 1 2 2 2 |
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1|
__________________________________________________________________________|
Islets, Pancreatic | + + |
__________________________________________________________________________|
Parathyroid Gland | + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 3 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + |
C-Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + M |
Hyperplasia | |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Ovary | + + + + + + |
__________________________________________________________________________|
Oviduct | + + + + |
__________________________________________________________________________|
Uterus | + + + + |
Dilatation | 4 |
Inflammation, Chronic Active | 3 |
Endometrium, Hyperplasia, Cystic, | |
Glandular | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + + + + +|
Neutrophilia | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + I + + + + + + + + + +|
Femoral, Atrophy | |
Femoral, Hemorrhage, Acute | |
Femoral, Hyperplasia | 3 4 3 |
Femoral, Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Lymph Node | + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | M |
Cyst | |
Ectasia | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 1| 7| 7|
DAY ON TEST | 2| 2| 3| 0| 3| 3| 3| 2| 6| 2| 2| 3| 3| 3| 3| 3| 3| 3| 8| 2| 3| 2| 4| 1| 3|
| 9| 9| 1| 5| 2| 0| 0| 3| 4| 9| 9| 0| 2| 1| 1| 0| 2| 1| 8| 9| 1| 9| 0| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 4 2 3 2 2 2 2|
Hyperplasia, Lymphoid | |
Pigmentation, Hemosiderin | 2 2 3 1 3 3 2 2 2 2 2 2 2 2 3 2 2 3 2 2 2 2 2 2 2|
__________________________________________________________________________|
Thymus | + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M |
Hyperplasia, Cystic | 1 3 |
__________________________________________________________________________|
Skin | + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + I + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + |
Compression | |
Hydrocephalus | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + |
__________________________________________________________________________|
Nose | + M |
__________________________________________________________________________|
Trachea | + M + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + |
Cornea, Inflammation, Chronic | 2 |
Lens, Cataract | 3 3 3 3 3 3 3 3 3 3 3 |
Retina, Atrophy | 3 3 3 3 3 3 3 3 3 3 3 3 |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 2 3 1 2 2 2 2 2 2 2 3 2 1 3 1 1 2 2 2|
Renal Tubule, Pigmentation, | |
Hemosiderin | 1 2 1 2 1 1 1 1 1 2 2 2 2 2 2 1 2 2 2 2 2 2 1 2|
__________________________________________________________________________|
Ureter | + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 2| 2| 1| 3| 2| 3| 9| 3| 3| 2| 3| 2| 2| 2| |
| 0| 0| 1| 1| 0| 2| 9| 0| 1| 2| 5| 9| 9| 7| 0| 9| 2| 3| 0| 0| 9| 0| 8| 8| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
2 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 8 |
Foreign Body | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A | 4 |
Inflammation, Chronic Active | 4 | 1 4.0|
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 6 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A | 3 |
__________________________________________________________________________|____________|
Intestine Small | + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A | 3 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A | 3 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 5 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X| 45 |
Clear Cell Focus | | 1 |
Degeneration, Cystic | | 1 1.0|
Hepatodiaphragmatic Nodule | X | 2 |
Inflammation, Chronic | 2 2 2 1 2 2 2 2 1 1 3 2 2 | 30 1.6|
Inflammation, Necrotizing | 1 | 1 1.0|
Vacuolization Cytoplasmic | 1 3 | 3 2.0|
Bile Duct, Hyperplasia | 1 | 3 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 7 |
Inflammation, Chronic | 4 | 2 3.5|
Necrosis | 4 | 2 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + | 6 |
Acinus, Atrophy | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + | 8 |
__________________________________________________________________________|____________|
Stomach | + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 5 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + A | 4 |
Necrosis, Coagulative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + + + | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + | 8 |
__________________________________________________________________________|____________|
Heart | + + + + | 7 |
Cardiomyopathy, Chronic | 2 | 2 2.0|
Coronary Artery, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 2| 2| 1| 3| 2| 3| 9| 3| 3| 2| 3| 2| 2| 2| |
| 0| 0| 1| 1| 0| 2| 9| 0| 1| 2| 5| 9| 9| 7| 0| 9| 2| 3| 0| 0| 9| 0| 8| 8| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
2 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Chronic Active | 2 | 1 2.0|
Endocardium, Proliferation | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Degeneration, Fatty | 1 1 1 2 2 | 10 1.5|
Hyperplasia | 2 1 2 2 1 2 2 1 2 2 2 1 2 2| 23 1.8|
Hypertrophy | 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 4 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 5 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M | 4 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 33 |
Pars Distalis, Angiectasis | | 1 4.0|
Pars Distalis, Cyst | X X X | 3 |
Pars Distalis, Hyperplasia | 2 2 3 3 2 2 2 2 2 | 18 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 6 |
C-Cell, Hyperplasia | 1 2 | 3 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + + | 5 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Oviduct | + + + + + + | 10 |
__________________________________________________________________________|____________|
Uterus | + + M + + + + + + + + | 14 |
Dilatation | 3 | 2 3.5|
Inflammation, Chronic Active | | 1 3.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Neutrophilia | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 2| 2| 1| 3| 2| 3| 9| 3| 3| 2| 3| 2| 2| 2| |
| 0| 0| 1| 1| 0| 2| 9| 0| 1| 2| 5| 9| 9| 7| 0| 9| 2| 3| 0| 0| 9| 0| 8| 8| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
2 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Femoral, Atrophy | 4 | 1 4.0|
Femoral, Hemorrhage, Acute | 4 | 1 4.0|
Femoral, Hyperplasia | 4 2 4 3 2 3 2 4 2 | 12 3.0|
Femoral, Hyperplasia, Reticulum Cell | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 12 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 4 |
Cyst | X | 1 |
Ectasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 | 2 2.5|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 3 2 2 3 2 2 2 2 2 2 2 4 2 2 2 2| 48 2.1|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Pigmentation, Hemosiderin | 2 1 3 2 2 2 2 1 2 2 3 2 2 2 3 2 3 2 1 3 2 1 3 1| 49 2.1|
__________________________________________________________________________|____________|
Thymus | + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + +| 17 |
Hyperplasia, Cystic | 2 2 2 3 2 2 2 3 2 | 11 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + +| 20 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 5 |
Compression | X | 1 |
Hydrocephalus | 4 | 1 4.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + | 5 |
__________________________________________________________________________|____________|
Nose | + + + | 4 |
__________________________________________________________________________|____________|
Trachea | + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 2| 2| 1| 3| 2| 3| 9| 3| 3| 2| 3| 2| 2| 2| |
| 0| 0| 1| 1| 0| 2| 9| 0| 1| 2| 5| 9| 9| 7| 0| 9| 2| 3| 0| 0| 9| 0| 8| 8| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
2 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + | 32 |
Cornea, Inflammation, Chronic | | 1 2.0|
Lens, Cataract | 3 3 3 3 3 3 3 3 3 3 2 3 3 3 3 3 3 3 3 | 30 3.0|
Retina, Atrophy | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 | 32 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + | 6 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 2 1 1 2 1 2 1 2 2 1 1 1 1 2 1 2 1 1 1| 39 1.7|
Renal Tubule, Pigmentation, | | |
Hemosiderin | 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2| 48 1.8|
__________________________________________________________________________|____________|
Ureter | + + + + + + | 12 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 3| 3| 3| 3| 2| 3| 4| 3| 1| 3| 3| 3| 3| 3| 3| 9| 0| 2| 3| 3| 3| 0|
| 0| 1| 7| 2| 0| 0| 2| 9| 0| 4| 2| 9| 0| 2| 1| 2| 0| 1| 5| 5| 9| 1| 2| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
18 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + A + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + A|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + A|
Inflammation, Chronic Active | 2 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + + + + + + A|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + A + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + A + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic | 1 2 1 2 1 1 1 2 2 3 1 1 2 2 1 3 2 |
Inflammation, Necrotizing | |
Necrosis, Coagulative | 3|
Pigmentation, Hemosiderin | |
Vacuolization Cytoplasmic | 3 |
Bile Duct, Hyperplasia | 1 1 1 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 4 1 |
Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +|
Ectopic Tissue | X |
Inflammation, Chronic | 1 4 |
Acinus, Atrophy | 1 1 1 2 1 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + A + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + A + + + + + + + + + + + + + + A|
Inflammation, Chronic Active | 3 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + A|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric Artery, Inflammation, | |
Chronic Active | 4 3 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 3| 3| 3| 3| 2| 3| 4| 3| 1| 3| 3| 3| 3| 3| 3| 9| 0| 2| 3| 3| 3| 0|
| 0| 1| 7| 2| 0| 0| 2| 9| 0| 4| 2| 9| 0| 2| 1| 2| 0| 1| 5| 5| 9| 1| 2| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
18 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 1 1 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 1 2 2 1 2 1 |
Hyperplasia | 2 2 1 3 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 1 2 1 1 2 1 2 1 2 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Parathyroid Gland | M + + + M + + + + + + M + + + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X X X X X |
Pars Distalis, Degeneration, Cystic | |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 1 1|
Pars Distalis, Inflammation, Chronic | |
Pars Nervosa, Hyperplasia, Glandular | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + A + + + + + + + + + + + + + + A|
Inflammation, Chronic Active | 2 |
C-Cell, Hyperplasia | 1 1 1 2 2 2 1 2 1 2 2 2 2 1 2 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + M + + + + + M + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
Inflammation, Chronic Active | 2 2 1 3 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + A + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 4 3 |
Hemorrhage, Chronic | 4 |
Inflammation, Chronic Active | 3 |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 2 |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + + + + |
Neutrophilia | X |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 3| 3| 3| 3| 2| 3| 4| 3| 1| 3| 3| 3| 3| 3| 3| 9| 0| 2| 3| 3| 3| 0|
| 0| 1| 7| 2| 0| 0| 2| 9| 0| 4| 2| 9| 0| 2| 1| 2| 0| 1| 5| 5| 9| 1| 2| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
18 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + I + + + A + + + + + M + + + + + + + + +|
Femoral, Hyperplasia | 2 2 4 3 2 2 2 4 2 3 3 4 3 2 3 2 3|
Femoral, Hyperplasia, Re Cell | 3 2 2 |
Femoral, Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Pigmentation, Hemosiderin | 2 |
Mediastinal, Cyst | X |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 3 |
Pancreatic, Pigmentation, Hemosiderin| 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Fibrosis | 2 2 2 3 2 2 2 2 4 3 2 2 2 3 2 2 2 3 2 2|
Hematopoietic Cell Proliferation | 2 2 2 2 2 1 3 1 2 1 3 1 1 4 3 1 1 |
Infiltration Cellular, Lipocyte | 1 2 3 3 |
Inflammation, Chronic Active | 4 |
Pigmentation, Hemosiderin | 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 3 1 2 2 2 2 |
Capsule, Cyst | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + M + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 2 2 1 3 2 3 3 4 4 2 3 3 4 2 2 2 2 4 3 4 4 2 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 3| 3| 3| 3| 2| 3| 4| 3| 1| 3| 3| 3| 3| 3| 3| 9| 0| 2| 3| 3| 3| 0|
| 0| 1| 7| 2| 0| 0| 2| 9| 0| 4| 2| 9| 0| 2| 1| 2| 0| 1| 5| 5| 9| 1| 2| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
18 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | 2 4 |
Mediastinum, Inflammation, Chronic | |
Active | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 2 2 2 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
Anterior Chamber, Inflammation, | |
Suppurative | |
Lens, Cataract | 3 3 3 3 2 3 3 3 3 3 3 3 3 3 3 |
Retina, Atrophy | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + M + + + + M +|
Atrophy | 2 |
Inflammation, Chronic | 2 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Chronic Active | 2 |
Nephropathy, Chronic | 1 2 1 1 1 1 1 1 1 1 2 1 2 2 1 1 1 1 3 2 2|
Renal Tubule, Pigmentation, | |
Hemosiderin | 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
__________________________________________________________________________|
Ureter | + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A|
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 5| |
DAY ON TEST | 2| 3| 3| 2| 3| 3| 2| 3| 3| 1| 2| 3| 3| 3| 2| 3| 5| 8| 6| 3| 3| 1| 3| 3| 2| |
| 9| 2| 2| 6| 0| 0| 9| 0| 2| 1| 9| 2| 1| 1| 9| 1| 2| 8| 5| 1| 0| 6| 2| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
18 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + A + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + A + + +| 46 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + A + + +| 46 |
Inflammation, Chronic Active | | 1 2.0|
Parasite Metazoan | X X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + A + + +| 47 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + M + A + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X| 44 |
Clear Cell Focus | X X | 3 |
Hepatodiaphragmatic Nodule | X X | 3 |
Inflammation, Chronic | 2 1 3 2 2 2 2 1 1 1 2 1 2 2 1 1 1 1 2 | 36 1.6|
Inflammation, Necrotizing | 2 | 1 2.0|
Necrosis, Coagulative | | 1 3.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
Vacuolization Cytoplasmic | | 1 3.0|
Bile Duct, Hyperplasia | 1 1 1 1 1 | 9 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Inflammation, Chronic | 2 2 2 1 1 1 | 8 1.8|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ectopic Tissue | | 1 |
Inflammation, Chronic | | 2 2.5|
Acinus, Atrophy | 2 1 1 1 2 1 1 2 | 15 1.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | | 2 3.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 5| |
DAY ON TEST | 2| 3| 3| 2| 3| 3| 2| 3| 3| 1| 2| 3| 3| 3| 2| 3| 5| 8| 6| 3| 3| 1| 3| 3| 2| |
| 9| 2| 2| 6| 0| 0| 9| 0| 2| 1| 9| 2| 1| 1| 9| 1| 2| 8| 5| 1| 0| 6| 2| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
18 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mesenteric Artery, Inflammation, | | |
Chronic Active | | 2 3.5|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 44 1.9|
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | 2 1 3 3 | 11 1.7|
Hyperplasia | 2 2 2 2 2 2 2 3 2 2 2 | 20 2.1|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 1 2 1 2 2| 24 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + M + + + + + M + + + M + + + +| 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | X X X X X | 12 |
Pars Distalis, Degeneration, Cystic | 2| 1 2.0|
Pars Distalis, Hyperplasia | 2 2 2 2 | 16 1.9|
Pars Distalis, Inflammation, Chronic | 2 | 1 2.0|
Pars Nervosa, Hyperplasia, Glandular | 2| 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | | 1 2.0|
C-Cell, Hyperplasia | 1 1 2 1 2 2 2 2 2 2 2 2 2 1 1 2 2 2 2 | 39 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 1 3 | 5 2.0|
Inflammation, Chronic Active | 2 3 | 7 2.1|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | X X| 4 |
__________________________________________________________________________|____________|
Oviduct | + + + + + + + + + + + + + + + + + + + M + + M| 42 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 5| |
DAY ON TEST | 2| 3| 3| 2| 3| 3| 2| 3| 3| 1| 2| 3| 3| 3| 2| 3| 5| 8| 6| 3| 3| 1| 3| 3| 2| |
| 9| 2| 2| 6| 0| 0| 9| 0| 2| 1| 9| 2| 1| 1| 9| 1| 2| 8| 5| 1| 0| 6| 2| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
18 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Dilatation | 3 3 2 | 6 3.0|
Hemorrhage, Chronic | | 1 4.0|
Inflammation, Chronic Active | | 1 3.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 2 2 1 2 3 1 | 8 1.9|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + + + + + + +| 43 |
Neutrophilia | X X | 3 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Femoral, Hyperplasia | 3 3 2 2 3 4 2 2 2 4 2 2 2 3 4 4 3 4 2 4| 37 2.8|
Femoral, Hyperplasia, Re Cell | 4 | 4 2.8|
Femoral, Hyperplasia, Reticulum Cell | 2 2 2 1 2 1 2 | 7 1.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bronchial, Pigmentation, Hemosiderin | | 1 2.0|
Mediastinal, Cyst | X | 2 |
Mediastinal, Infiltration Cellular, | | |
Histiocyte | 3 | 2 3.0|
Pancreatic, Pigmentation, Hemosiderin| | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 2 |
Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + +| 9 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Fibrosis | 3 3 2 3 3 2 2 2 3 3 3 2 2 2 2 2 4 3 3 2 3 2 | 42 2.4|
Hematopoietic Cell Proliferation | 2 2 2 2 2 1 2 3 3 4 2 4 2 3 4| 32 2.2|
Infiltration Cellular, Lipocyte | 2 2 2 2 2 2 2 | 11 2.1|
Inflammation, Chronic Active | | 1 4.0|
Pigmentation, Hemosiderin | 2 1 2 3 2 3 3 2 2 2 2 2 2 1 2 2 2 2 2 1 1 2 2 2 2| 48 2.0|
Capsule, Cyst | X X | 3 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M M + + + + + + M + + + + + +| 44 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 3 1 2 3 2 4 2 2 2 1 4 2 2 3 2 2 3 4 2 2 3 2 2| 48 2.6|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 5| |
DAY ON TEST | 2| 3| 3| 2| 3| 3| 2| 3| 3| 1| 2| 3| 3| 3| 2| 3| 5| 8| 6| 3| 3| 1| 3| 3| 2| |
| 9| 2| 2| 6| 0| 0| 9| 0| 2| 1| 9| 2| 1| 1| 9| 1| 2| 8| 5| 1| 0| 6| 2| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
18 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X | 5 |
Hydrocephalus | 3 2 2 | 4 2.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma | 1| 1 1.0|
Inflammation, Chronic Active | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 2 3.0|
Mediastinum, Inflammation, Chronic | | |
Active | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 2 2 2 2 2 | 11 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | | 2 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 | 4 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + | 31 |
Inflammation, Chronic | 4 | 1 4.0|
Anterior Chamber, Inflammation, | | |
Suppurative | 2 | 1 2.0|
Lens, Cataract | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 | 30 3.0|
Retina, Atrophy | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 | 31 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + M + + + + + M + + + + + + + + + + + + + M M| 44 |
Atrophy | | 1 2.0|
Inflammation, Chronic | 2 2 2 2 | 6 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 5| |
DAY ON TEST | 2| 3| 3| 2| 3| 3| 2| 3| 3| 1| 2| 3| 3| 3| 2| 3| 5| 8| 6| 3| 3| 1| 3| 3| 2| |
| 9| 2| 2| 6| 0| 0| 9| 0| 2| 1| 9| 2| 1| 1| 9| 1| 2| 8| 5| 1| 0| 6| 2| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
18 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Cyst | | 1 |
Inflammation, Chronic Active | | 1 2.0|
Nephropathy, Chronic | 1 1 1 1 2 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 | 41 1.2|
Renal Tubule, Pigmentation, | | |
Hemosiderin | 3 3 3 2 3 3 3 3 3 2 3 3 3 3 3 3 2 3 3 3 3 2 3 3 2| 50 2.9|
__________________________________________________________________________|____________|
Ureter | + + | 9 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7|
DAY ON TEST | 8| 1| 5| 3| 2| 3| 3| 2| 3| 0| 3| 3| 3| 7| 3| 3| 3| 3| 3| 5| 2| 3| 2| 2| 2|
| 1| 1| 7| 1| 9| 0| 1| 9| 1| 5| 0| 1| 1| 4| 0| 0| 2| 0| 1| 3| 1| 2| 0| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
6 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + |
Foreign Body | 2 4 |
__________________________________________________________________________|
Intestine Large | + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | A A + A A A |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A A |
Inflammation, Necrotizing | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + A + |
__________________________________________________________________________|
Intestine Small, Ileum | A A + A A A |
__________________________________________________________________________|
Intestine Small, Jejunum | A A + + A A |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X|
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic | 2 2 2 2 2 3 1 1 2 2 1 1 1 2 2 2|
Inflammation, Necrotizing | 1 |
Necrosis, Coagulative | 2 4 |
Bile Duct, Hyperplasia | 1 |
Portal Vein, Intima, Proliferation | |
__________________________________________________________________________|
Mesentery | + + + + + + |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + |
Inflammation, Chronic | 2 |
Acinus, Atrophy | 2 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + |
Cardiomyopathy, Chronic | 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Angiectasis | 2 |
Degeneration, Fatty | 2 2 1 2 2 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7|
DAY ON TEST | 8| 1| 5| 3| 2| 3| 3| 2| 3| 0| 3| 3| 3| 7| 3| 3| 3| 3| 3| 5| 2| 3| 2| 2| 2|
| 1| 1| 7| 1| 9| 0| 1| 9| 1| 5| 0| 1| 1| 4| 0| 0| 2| 0| 1| 3| 1| 2| 0| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
6 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 2 1 3 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + A |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + |
Pars Distalis, Atypia Cellular | X |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + |
C-Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + |
Hyperplasia | |
Inflammation, Chronic Active | |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + |
Cyst | X X |
__________________________________________________________________________|
Oviduct | + + + + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + |
Dilatation | 4 |
Inflammation, Chronic Active | |
Endometrium, Hyperplasia, Cystic, | |
Glandular | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + I + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia | 3 2 2 4 2 4 3 3 3 |
Femoral, Hyperplasia, Reticulum Cell | 2 3 4 3 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + |
Mediastinal, Inflammation, | |
Suppurative | 2 |
Renal, Cyst | X |
Renal, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | |
Cyst | |
Edema | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7|
DAY ON TEST | 8| 1| 5| 3| 2| 3| 3| 2| 3| 0| 3| 3| 3| 7| 3| 3| 3| 3| 3| 5| 2| 3| 2| 2| 2|
| 1| 1| 7| 1| 9| 0| 1| 9| 1| 5| 0| 1| 1| 4| 0| 0| 2| 0| 1| 3| 1| 2| 0| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
6 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
Hematopoietic Cell Proliferation | 4 2 2 3 3 2 3 2 4 3 4 2 4 2 3 2 2 3 3 4 2 2 2 2|
Pigmentation, Hemosiderin | 3 1 3 3 3 3 2 3 3 3 3 3 2 2 3 3 3 3 3 2 2 3 2 2|
__________________________________________________________________________|
Thymus | + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 3 2 3 3 1 2 3 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + +|
Inflammation, Necrotizing | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + |
Compression | X X |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + |
Mediastinum, Inflammation, Chronic | |
Active | 4 |
__________________________________________________________________________|
Nose | + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + |
Inflammation, Chronic | |
Lens, Cataract | 3 3 3 3 3 3 3 3 3 3 3 3 |
Retina, Atrophy | 3 3 3 3 3 3 3 3 3 3 3 3 |
__________________________________________________________________________|
Harderian Gland | + + + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 2 1 1 2 2 1 2 2 2 1 1 1 1 2 2 2 4 2 2 1|
Renal Tubule, Pigmentation, | |
Hemosiderin | 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 3 2 1 2 2|
__________________________________________________________________________|
Ureter | + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + M |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| |
DAY ON TEST | 3| 0| 2| 3| 3| 3| 2| 2| 2| 3| 3| 2| 2| 3| 9| 3| 2| 3| 3| 2| 3| 2| 3| 2| 3| |
| 1| 1| 9| 2| 0| 9| 9| 9| 6| 1| 1| 9| 9| 2| 4| 0| 9| 0| 1| 9| 2| 9| 1| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
6 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 12 |
Foreign Body | 2 | 3 2.7|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + A A | 3 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + | 8 |
Inflammation, Necrotizing | 4 | 1 4.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A M + M | 6 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | M + A A | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A M A A | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X| 46 |
Hepatodiaphragmatic Nodule | X | 2 |
Inflammation, Chronic | 2 2 2 3 3 1 2 1 1 1 2 2 2 2 2 1| 32 1.8|
Inflammation, Necrotizing | 2 3 | 3 2.0|
Necrosis, Coagulative | | 2 3.0|
Bile Duct, Hyperplasia | | 1 1.0|
Portal Vein, Intima, Proliferation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 11 |
Inflammation, Chronic | 2 | 2 1.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 12 |
Inflammation, Chronic | 2 | 2 2.0|
Acinus, Atrophy | | 3 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 12 |
__________________________________________________________________________|____________|
Stomach | + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | A + + + | 9 |
__________________________________________________________________________|____________|
Stomach, Glandular | A + + + | 9 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________|____________|
Tooth | + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + | 12 |
__________________________________________________________________________|____________|
Heart | + + + + | 10 |
Cardiomyopathy, Chronic | 2 2 2 1 | 7 1.9|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| |
DAY ON TEST | 3| 0| 2| 3| 3| 3| 2| 2| 2| 3| 3| 2| 2| 3| 9| 3| 2| 3| 3| 2| 3| 2| 3| 2| 3| |
| 1| 1| 9| 2| 0| 9| 9| 9| 6| 1| 1| 9| 9| 2| 4| 0| 9| 0| 1| 9| 2| 9| 1| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
6 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X | 1 |
Angiectasis | | 1 2.0|
Degeneration, Fatty | 1 1 1 2 | 9 1.6|
Hyperplasia | 2 2 3 2 1 2 2 2 1 2 2 | 18 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 1 | 7 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 9 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + | 9 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + +| 35 |
Pars Distalis, Atypia Cellular | | 1 |
Pars Distalis, Cyst | X X X X X | 7 |
Pars Distalis, Hyperplasia | 3 2 3 2 2 2 | 9 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 11 |
C-Cell, Hyperplasia | 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + | 11 |
Hyperplasia | 3 | 1 3.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Duct, Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + | 15 |
Cyst | X X | 4 |
__________________________________________________________________________|____________|
Oviduct | + + + | 8 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + | 20 |
Dilatation | 4 4 4 2 | 5 3.6|
Inflammation, Chronic Active | 4 | 1 4.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 2 4 2 | 3 2.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + + + + +| 37 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Hyperplasia | 3 2 2 2 2 3 2 2 2 3 4 2 | 21 2.6|
Femoral, Hyperplasia, Reticulum Cell | 2 2 | 7 2.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| |
DAY ON TEST | 3| 0| 2| 3| 3| 3| 2| 2| 2| 3| 3| 2| 2| 3| 9| 3| 2| 3| 3| 2| 3| 2| 3| 2| 3| |
| 1| 1| 9| 2| 0| 9| 9| 9| 6| 1| 1| 9| 9| 2| 4| 0| 9| 0| 1| 9| 2| 9| 1| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
6 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 17 |
Mediastinal, Inflammation, | | |
Suppurative | | 1 2.0|
Renal, Cyst | | 1 |
Renal, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 14 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 1 |
Cyst | X | 1 |
Edema | 4 | 1 4.0|
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 1 1 | 3 1.0|
Hematopoietic Cell Proliferation | 1 2 2 2 2 2 2 3 2 1 2 2 2 3 2 2 2 2 2 2 2 2 2 2| 48 2.4|
Pigmentation, Hemosiderin | 2 3 3 2 3 3 2 2 2 2 3 3 2 2 3 2 2 2 1 3 2 2 2 2 2| 49 2.4|
__________________________________________________________________________|____________|
Thymus | + + + + | 11 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + +| 22 |
Hyperplasia, Cystic | 2 2 2 2 2 2 2| 17 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + +| 21 |
Inflammation, Necrotizing | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 10 |
Compression | X X | 4 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + | 11 |
Mediastinum, Inflammation, Chronic | | |
Active | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + | 11 |
__________________________________________________________________________|____________|
Trachea | + + + + + | 13 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| |
DAY ON TEST | 3| 0| 2| 3| 3| 3| 2| 2| 2| 3| 3| 2| 2| 3| 9| 3| 2| 3| 3| 2| 3| 2| 3| 2| 3| |
| 1| 1| 9| 2| 0| 9| 9| 9| 6| 1| 1| 9| 9| 2| 4| 0| 9| 0| 1| 9| 2| 9| 1| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
6 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + +| 31 |
Inflammation, Chronic | 3 | 1 3.0|
Lens, Cataract | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 30 3.0|
Retina, Atrophy | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 31 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 1 2 2 1 2 2 1 1 1 2 1 2 2 2 2 1 1 2 2 2 1 1 1 2| 45 1.6|
Renal Tubule, Pigmentation, | | |
Hemosiderin | 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2| 50 1.9|
__________________________________________________________________________|____________|
Ureter | + + + + + + +| 11 |
__________________________________________________________________________|____________|
Urinary Bladder | A + + + | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7| 6| 4| 7| 5| 4| 7| 6| 7| 6| 2| 7| 6| 7|
DAY ON TEST | 2| 1| 3| 3| 3| 2| 3| 2| 2| 3| 3| 2| 5| 5| 3| 6| 6| 3| 3| 3| 5| 6| 3| 6| 3|
| 9| 0| 1| 1| 0| 1| 1| 9| 6| 3| 3| 1| 5| 5| 2| 8| 6| 0| 9| 2| 5| 3| 0| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 4 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + + + +|
Inflammation, Chronic Active | |
Parasite Metazoan | X|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X|
Degeneration, Cystic | 2 2 2 2 2 1 |
Eosinophilic Focus | X X X |
Hepatodiaphragmatic Nodule | X X|
Inflammation, Chronic | 2 2 2 2 |
Inflammation, Necrotizing | 1 2 2|
Necrosis, Coagulative | 2 2 |
Pigmentation, Hemosiderin | |
Vacuolization Cytoplasmic | 2 2 3 2 |
Bile Duct, Hyperplasia | 2 1 1 2 2 4 2 2 3 2 1 2 1 1 2 1 2 1|
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 1 |
Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 1 2 4 2 2 2 1 2|
Duct, Ectasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | 2 |
Inflammation, Chronic Active | 2 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | 2 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Tongue | + + |
Foreign Body | 2 2 |
Inflammation, Chronic Active | 3 3 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7| 6| 4| 7| 5| 4| 7| 6| 7| 6| 2| 7| 6| 7|
DAY ON TEST | 2| 1| 3| 3| 3| 2| 3| 2| 2| 3| 3| 2| 5| 5| 3| 6| 6| 3| 3| 3| 5| 6| 3| 6| 3|
| 9| 0| 1| 1| 0| 1| 1| 9| 6| 3| 3| 1| 5| 5| 2| 8| 6| 0| 9| 2| 5| 3| 0| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peridontal Tissue, Inflammation, | |
Chronic Active | 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric Artery, Intima, | |
Proliferation | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 2 2 3 2 3 3 2 2 2 1 3 2 2 2 3 2 3 3 2|
Atrium, Thrombosis | |
Endocardium, Proliferation | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 2 2 |
Hyperplasia | 2 2 2 2 2 3 2 2|
Hypertrophy | |
Necrosis, Coagulative | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 |
Mineralization | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | |
__________________________________________________________________________|
Preputial Gland | M + + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 2 2 2 2 3 2 2 2 3 2 2 3 2 2 2 2 2 2 2 3 1 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 3 3 3 1 2 2 2 2 2 2 2 1 2 2 |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7| 6| 4| 7| 5| 4| 7| 6| 7| 6| 2| 7| 6| 7|
DAY ON TEST | 2| 1| 3| 3| 3| 2| 3| 2| 2| 3| 3| 2| 5| 5| 3| 6| 6| 3| 3| 3| 5| 6| 3| 6| 3|
| 9| 0| 1| 1| 0| 1| 1| 9| 6| 3| 3| 1| 5| 5| 2| 8| 6| 0| 9| 2| 5| 3| 0| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + M + + + M + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 1 2 2 2 2 2 2 2 1 2 |
Seminiferous Tubule, Atrophy | 4 4 4 4 4 4 4 4 4 2 4 4 4 4 2 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + + + + +|
Leukocytosis | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia | 3 2 3 3 3 4 3 4 3 4 3|
Femoral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M +|
Cyst | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
Cyst | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | 1 1 1 2 1 1 1 2 1 1 2 2 1 4 1 2 2 1 1|
Infarct, Acute | |
Pigmentation, Hemosiderin | 1 2 1 1 1 2 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1|
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + M + + + + + + + M + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + M M + + + + + + + + M + + + M M M + M M M M|
Hyperplasia, Cystic | 4 2 1 3 1 1 4 2 3 2 3 |
__________________________________________________________________________|
Skin | M + + M + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | M + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X |
Hemorrhage, Acute | 3 |
Hydrocephalus | 2 2 2 4 |
Infarct, Chronic | 2 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | + |
Degeneration | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7| 6| 4| 7| 5| 4| 7| 6| 7| 6| 2| 7| 6| 7|
DAY ON TEST | 2| 1| 3| 3| 3| 2| 3| 2| 2| 3| 3| 2| 5| 5| 3| 6| 6| 3| 3| 3| 5| 6| 3| 6| 3|
| 9| 0| 1| 1| 0| 1| 1| 9| 6| 3| 3| 1| 5| 5| 2| 8| 6| 0| 9| 2| 5| 3| 0| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | 3 |
Inflammation, Chronic | 2 2 |
Pigmentation, Hemosiderin | 2 |
Alveolar Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 1 |
Septum, Thrombosis, Multiple | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 3 4 |
Retina, Atrophy | 4 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 3 3 3 3 2 3 4 4 2 2 3 4 4 3 2 2 3 3 3 3 4 3 3|
Renal Tubule, Pigmentation, | |
Hemosiderin | 1 1 1 2 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Ureter | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urethra | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | 2 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 7| 6| 6| 3| 0| 7| 5| 7| 6| 7| 6| 7| 6| 5| 7| 6| 5| 7| | |
DAY ON TEST | 3| 2| 3| 2| 3| 7| 3| 8| 2| 3| 7| 0| 5| 3| 7| 0| 8| 3| 4| 1| 0| 8| 8| 2| | |
| 2| 9| 0| 8| 1| 8| 2| 8| 7| 0| 2| 9| 4| 1| 4| 1| 8| 0| 7| 2| 4| 0| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | A |
VEHICLE | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Foreign Body | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + A + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A + M + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + M + + + + | 46 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + | 47 |
Inflammation, Chronic Active | 2 1 | 2 1.5|
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + A + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + M + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Basophilic Focus | X X X X | 14 |
Degeneration, Cystic | 2 2 2 2 | 10 1.9|
Eosinophilic Focus | | 3 |
Hepatodiaphragmatic Nodule | X | 3 |
Inflammation, Chronic | 2 2 1 1 | 8 1.8|
Inflammation, Necrotizing | 2 | 4 1.8|
Necrosis, Coagulative | 2 2 2 1 | 6 1.8|
Pigmentation, Hemosiderin | 2 | 1 2.0|
Vacuolization Cytoplasmic | 4 2 | 6 2.5|
Bile Duct, Hyperplasia | 1 2 2 2 2 2 1 3 2 1 3 2 1 2 3 2 1 3 2 2 3 2 3 | 41 1.9|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Inflammation, Chronic | 3 4 2 | 6 2.2|
Necrosis | 4 4 | 3 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + A + + + + + + + + + + + + + | 48 |
Acinus, Atrophy | 1 2 1 3 3 1 1 1 | 18 1.8|
Duct, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Granuloma | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + A + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + M + + + + + + + A + + + + + + + + + + + + + | 47 |
Acanthosis | | 1 2.0|
Hyperkeratosis | | 1 2.0|
Inflammation, Chronic Active | | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + A + + + + + + + + + + + + + | 48 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 7| 6| 6| 3| 0| 7| 5| 7| 6| 7| 6| 7| 6| 5| 7| 6| 5| 7| | |
DAY ON TEST | 3| 2| 3| 2| 3| 7| 3| 8| 2| 3| 7| 0| 5| 3| 7| 0| 8| 3| 4| 1| 0| 8| 8| 2| | |
| 2| 9| 0| 8| 1| 8| 2| 8| 7| 0| 2| 9| 4| 1| 4| 1| 8| 0| 7| 2| 4| 0| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | A |
VEHICLE | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | | 1 2.0|
Necrosis, Coagulative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 2 |
Foreign Body | | 2 2.0|
Inflammation, Chronic Active | | 2 3.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Peridontal Tissue, Inflammation, | | |
Chronic Active | | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Mesenteric Artery, Intima, | | |
Proliferation | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Cardiomyopathy, Chronic | 3 3 2 2 3 3 3 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 | 44 2.3|
Atrium, Thrombosis | X X X X X | 5 |
Endocardium, Proliferation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Degeneration, Fatty | 2 2 2 2 2 2 2 | 10 2.0|
Hyperplasia | 2 2 2 2 2 3 2 2 3 | 17 2.2|
Hypertrophy | 2 | 1 2.0|
Necrosis, Coagulative | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia | 2 2 2 2 3 2 2 2 2 | 15 2.1|
Mineralization | 3 | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + A + + + + + + + + + + + + + | 48 |
Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + + + | 47 |
Pars Distalis, Cyst | X X | 3 |
Pars Distalis, Hyperplasia | 2 2 2 2 3 2 3 2 | 11 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + A + + + + + + + + + + + + + | 48 |
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia | 2 2 1 2 2 2 2 | 19 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 7| 6| 6| 3| 0| 7| 5| 7| 6| 7| 6| 7| 6| 5| 7| 6| 5| 7| | |
DAY ON TEST | 3| 2| 3| 2| 3| 7| 3| 8| 2| 3| 7| 0| 5| 3| 7| 0| 8| 3| 4| 1| 0| 8| 8| 2| | |
| 2| 9| 0| 8| 1| 8| 2| 8| 7| 0| 2| 9| 4| 1| 4| 1| 8| 0| 7| 2| 4| 0| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | A |
VEHICLE | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Atrophy, Diffuse | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + M + + + + + + + + + + + + + + + + + + + | 46 |
Hyperplasia | 3 3 | 2 3.0|
Inflammation, Chronic Active | 2 2 2 3 2 2 2 2 2 2 3 2 2 3 2 2 2 1 2 2 2 2 | 45 2.1|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Inflammation, Chronic Active | 2 1 2 2 1 2 2 2 2 2 2 2 3 2 2 2 3 | 32 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + | 36 |
Inflammation, Chronic Active | | 3 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Interstitial Cell, Hyperplasia | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 26 1.8|
Seminiferous Tubule, Atrophy | 4 4 4 3 4 4 4 4 3 4 4 3 3 3 3 3 4 | 33 3.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + + + + + + + | 44 |
Leukocytosis | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Femoral, Hyperplasia | 3 3 3 3 2 4 3 4 4 4 3 3 4 3 3 | 26 3.2|
Femoral, Myelofibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cyst | X X X X | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 10 |
Cyst | X | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Fibrosis | 2 | 3 2.0|
Hematopoietic Cell Proliferation | 1 1 2 1 2 1 1 1 1 2 1 1 | 31 1.4|
Infarct, Acute | 4 | 1 4.0|
Pigmentation, Hemosiderin | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 | 37 1.1|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + + + + M + + + + M + + + + + | 43 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + + M M M + + + + M + + + + + + + M | 32 |
Hyperplasia, Cystic | 1 1 2 2 2 2 2 2 3 2 2 3 2 3 | 25 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 7| 6| 6| 3| 0| 7| 5| 7| 6| 7| 6| 7| 6| 5| 7| 6| 5| 7| | |
DAY ON TEST | 3| 2| 3| 2| 3| 7| 3| 8| 2| 3| 7| 0| 5| 3| 7| 0| 8| 3| 4| 1| 0| 8| 8| 2| | |
| 2| 9| 0| 8| 1| 8| 2| 8| 7| 0| 2| 9| 4| 1| 4| 1| 8| 0| 7| 2| 4| 0| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | A |
VEHICLE | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Compression | X | 4 |
Hemorrhage, Acute | | 1 3.0|
Hydrocephalus | 3 | 5 2.6|
Infarct, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + + + | 4 |
Degeneration | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hemorrhage, Acute | 3 2 | 3 2.7|
Inflammation, Chronic | | 2 2.0|
Pigmentation, Hemosiderin | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 3 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + M + | 48 |
Inflammation, Chronic Active | 2 3 4 2 2 | 6 2.7|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 | 4 1.5|
Septum, Thrombosis, Multiple | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + | 7 |
Lens, Cataract | 3 3 | 4 3.3|
Retina, Atrophy | 3 4 3 | 5 3.6|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + M M | 46 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + A + + + + + + + + + + + + + | 48 |
Nephropathy, Chronic | 4 3 3 2 4 2 3 2 2 2 2 2 4 2 2 2 3 2 2 3 2 2 3 | 46 2.8|
Renal Tubule, Pigmentation, | | |
Hemosiderin | 1 1 1 1 1 1 1 2 1 1 1 2 1 2 2 3 2 1 1 1 1 2 1 | 47 1.2|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Urethra | + + + + + + | 21 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 7| 6| 6| 3| 0| 7| 5| 7| 6| 7| 6| 7| 6| 5| 7| 6| 5| 7| | |
DAY ON TEST | 3| 2| 3| 2| 3| 7| 3| 8| 2| 3| 7| 0| 5| 3| 7| 0| 8| 3| 4| 1| 0| 8| 8| 2| | |
| 2| 9| 0| 8| 1| 8| 2| 8| 7| 0| 2| 9| 4| 1| 4| 1| 8| 0| 7| 2| 4| 0| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | A |
VEHICLE | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + A + + + + + + + + M + + + + | 47 |
Hemorrhage, Acute | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 3| 1| 2| 3| 5| 9| 8| 3| 3| 8| 5| 3| 3| 2| 3| 7| 3| 5| 3| 3| 3| 3|
| 2| 0| 6| 2| 5| 9| 2| 1| 3| 6| 0| 1| 7| 6| 2| 1| 9| 1| 3| 2| 1| 0| 2| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + |
Inflammation, Necrotizing | |
__________________________________________________________________________|
Intestine Large | + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + |
__________________________________________________________________________|
Intestine Large, Colon | + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + |
__________________________________________________________________________|
Intestine Small | + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + |
Metaplasia, Osseous | 3 |
Necrosis | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X X |
Degeneration, Cystic | 3 2 2 2 2 1 2 2 1|
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X X X X X X |
Inflammation, Chronic | 1 1 1 2 1 1 |
Inflammation, Necrotizing | 3 2 |
Necrosis, Coagulative | 3 |
Vacuolization Cytoplasmic | 2 |
Bile Duct, Hyperplasia | 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 3 2 2 2 2|
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Chronic | 3 3 3 3 3 |
Necrosis | 4 4 4 |
__________________________________________________________________________|
Pancreas | M + |
Pigmentation, Hemosiderin | |
Acinus, Atrophy | |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + |
__________________________________________________________________________|
Stomach | + + |
__________________________________________________________________________|
Stomach, Forestomach | + + |
Inflammation, Necrotizing | |
__________________________________________________________________________|
Stomach, Glandular | + + |
Necrosis, Coagulative | |
__________________________________________________________________________|
Tongue | + |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + |
Pulmonary Artery, Thrombosis | X |
__________________________________________________________________________|
Heart | + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 3| 1| 2| 3| 5| 9| 8| 3| 3| 8| 5| 3| 3| 2| 3| 7| 3| 5| 3| 3| 3| 3|
| 2| 0| 6| 2| 5| 9| 2| 1| 3| 6| 0| 1| 7| 6| 2| 1| 9| 1| 3| 2| 1| 0| 2| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy, Chronic | 2 2 2 4 2 2 2 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 2 |
Hyperplasia | 2 2 2 1 2 2 2 |
Hypertrophy | |
Necrosis, Coagulative | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 3 2 2 2 1 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | M + |
__________________________________________________________________________|
Parathyroid Gland | + + + + |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia | 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | |
Pars Intermedia, Angiectasis | 3|
__________________________________________________________________________|
Thyroid Gland | A + + + + |
C-Cell, Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + |
Inflammation, Chronic Active | 3 3 2 2 |
__________________________________________________________________________|
Prostate | + + |
Inflammation, Chronic Active | 3 1 |
__________________________________________________________________________|
Seminal Vesicle | + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 2 1 1 2 2 1 2 2 2 1 1 1 1|
Seminiferous Tubule, Atrophy | 4 2 3 4 4 4 4 4 4 4 4 2 4 4 4 4 4 4 4 4 4 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + + +|
Neutrophilia | X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia | 2 2 4 3 4 4 3 4 4 4 4 4 3 3 4 2 4 2 2 3|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 3| 1| 2| 3| 5| 9| 8| 3| 3| 8| 5| 3| 3| 2| 3| 7| 3| 5| 3| 3| 3| 3|
| 2| 0| 6| 2| 5| 9| 2| 1| 3| 6| 0| 1| 7| 6| 2| 1| 9| 1| 3| 2| 1| 0| 2| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Hyperplasia, Plasma Cell| 3 |
Renal, Cyst | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + |
Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
Cyst | X X |
Fibrosis | 2 |
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 4 3 3 1 1 3|
Hematopoietic Cell Proliferation | 2 2 2 2 1 2 1 3 4 2 2 2 2 3 2 1 2 1 4 1 3 1 1 1 1|
Pigmentation, Hemosiderin | 2 1 2 1 2 1 2 2 1 1 2 2 2 2 1 2 2 1 2|
__________________________________________________________________________|
Thymus | + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + |
Hyperplasia, Cystic | 2 2 3 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + |
Inflammation, Necrotizing | |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + |
Hydrocephalus | 3 |
__________________________________________________________________________|
Peripheral Nerve | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + |
Inflammation, Chronic | |
Mediastinum, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Nose | + + |
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Hemorrhage, Acute | |
Cornea, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 3| 1| 2| 3| 5| 9| 8| 3| 3| 8| 5| 3| 3| 2| 3| 7| 3| 5| 3| 3| 3| 3|
| 2| 0| 6| 2| 5| 9| 2| 1| 3| 6| 0| 1| 7| 6| 2| 1| 9| 1| 3| 2| 1| 0| 2| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Lens, Cataract | 3 3 3 3 |
Retina, Atrophy | 3 3 3 3 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Hemorrhagic | |
Nephropathy, Chronic | 3 3 3 3 2 4 3 2 3 3 4 3 2 2 4 3 3 3 2 3 2 2 4 2 3|
Renal Tubule, Degeneration | |
Renal Tubule, Pigmentation, | |
Hemosiderin | 2 1 1 1 1 1 1 1 2 1 1 1 1 1 2 1 1 1 2 2 2 1 1 2|
__________________________________________________________________________|
Ureter | + + + + + + + + + + + + + |
__________________________________________________________________________|
Urethra | + |
Inflammation, Hemorrhagic | |
__________________________________________________________________________|
Urinary Bladder | + + + |
Dilatation | 4 |
Inflammation, Hemorrhagic | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 5| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 2| 2| 2| 5| 2| 3| 3| 5| 2| 3| 5| 2| 3| 3| 3| 5| 2| 3| 3| 3| 7| 3| 1| 3| |
| 1| 9| 9| 6| 4| 9| 1| 1| 4| 9| 2| 1| 7| 0| 0| 1| 4| 9| 2| 0| 2| 4| 1| 4| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
2 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 5 |
Inflammation, Necrotizing | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small | + + + | 6 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 6 |
Metaplasia, Osseous | | 1 3.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Basophilic Focus | X X X X X X X X X X X X | 23 |
Degeneration, Cystic | 2 2 1 2 2 1 1 | 16 1.8|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | | 8 |
Inflammation, Chronic | 2 1 1 1 3 1 1 1 1 | 15 1.3|
Inflammation, Necrotizing | | 2 2.5|
Necrosis, Coagulative | 2 2 2 | 4 2.3|
Vacuolization Cytoplasmic | 2 3 1 | 4 2.0|
Bile Duct, Hyperplasia | 2 1 1 1 1 1 1 1 2 2 2 1 2 2 2 1 2 1 2 2 3 2| 45 1.8|
__________________________________________________________________________|____________|
Mesentery | + + + + + +| 11 |
Inflammation, Chronic | 3| 6 3.0|
Necrosis | 4| 4 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 8 |
Pigmentation, Hemosiderin | 3 | 1 3.0|
Acinus, Atrophy | 3 2 1 | 3 2.0|
Duct, Ectasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 6 |
__________________________________________________________________________|____________|
Stomach | + + + + | 6 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 6 |
Inflammation, Necrotizing | 4 | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 6 |
Necrosis, Coagulative | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 5| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 2| 2| 2| 5| 2| 3| 3| 5| 2| 3| 5| 2| 3| 3| 3| 5| 2| 3| 3| 3| 7| 3| 1| 3| |
| 1| 9| 9| 6| 4| 9| 1| 1| 4| 9| 2| 1| 7| 0| 0| 1| 4| 9| 2| 0| 2| 4| 1| 4| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
2 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + | 8 |
Pulmonary Artery, Thrombosis | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 18 |
Cardiomyopathy, Chronic | 2 2 2 2 2 2 2 2 | 15 2.1|
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | 1 2 1 2 2 2 2 1 2| 11 1.7|
Hyperplasia | 2 2 2 2 1 2| 13 1.8|
Hypertrophy | 2 | 1 2.0|
Necrosis, Coagulative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
Hyperplasia | 2 1 1 1 3 2 2 2 2 2 2 3 | 22 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 4 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 7 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + + + + | 18 |
Pars Distalis, Angiectasis | 4 | 1 4.0|
Pars Distalis, Hyperplasia | 2 | 2 2.0|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 1 | 1 1.0|
Pars Intermedia, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 8 |
C-Cell, Hyperplasia | 1 | 4 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + +| 20 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 12 |
Inflammation, Chronic Active | 2 2 | 6 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + | 6 |
Inflammation, Chronic Active | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 5| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 2| 2| 2| 5| 2| 3| 3| 5| 2| 3| 5| 2| 3| 3| 3| 5| 2| 3| 3| 3| 7| 3| 1| 3| |
| 1| 9| 9| 6| 4| 9| 1| 1| 4| 9| 2| 1| 7| 0| 0| 1| 4| 9| 2| 0| 2| 4| 1| 4| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
2 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Interstitial Cell, Hyperplasia | 2 2 2 2 1 1 2 2 1 1 1 1 1 1 | 29 1.5|
Seminiferous Tubule, Atrophy | 4 4 4 4 4 4 4 4 4 4 3 4 4 3 4 4 4 4 4 4 4 4| 44 3.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Neutrophilia | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Hyperplasia | 3 3 4 4 4 4 3 4 2 3 3 3 3 3 4 3| 36 3.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 16 |
Mediastinal, Hyperplasia, Plasma Cell| | 1 3.0|
Renal, Cyst | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 7 |
Ectasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 5 |
Cyst | | 2 |
Fibrosis | | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 1 2 1 3 | 11 2.2|
Hematopoietic Cell Proliferation | 1 1 1 2 3 3 3 1 4 1 1 4 1 2 1 1 1 1 1 1 1 4 1| 48 1.8|
Pigmentation, Hemosiderin | 2 1 2 3 2 2 2 1 2 2 2 2 2 2 2 1 2 1 2 1| 39 1.7|
__________________________________________________________________________|____________|
Thymus | M M + | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M | 6 |
Hyperplasia, Cystic | 2 | 6 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 18 |
Inflammation, Necrotizing | 3 | 1 3.0|
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femur, Fibrous Osteodystrophy | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + | 6 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 5 |
Hydrocephalus | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 5| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 2| 2| 2| 5| 2| 3| 3| 5| 2| 3| 5| 2| 3| 3| 3| 5| 2| 3| 3| 3| 7| 3| 1| 3| |
| 1| 9| 9| 6| 4| 9| 1| 1| 4| 9| 2| 1| 7| 0| 0| 1| 4| 9| 2| 0| 2| 4| 1| 4| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
2 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + | 7 |
Inflammation, Chronic | 2 | 1 2.0|
Mediastinum, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + | 5 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + | 11 |
Hemorrhage, Acute | 2 | 1 2.0|
Cornea, Inflammation, Chronic Active | 3 | 1 3.0|
Lens, Cataract | 3 3 3 3 3 3 3 | 11 3.0|
Retina, Atrophy | 3 3 3 3 3 3 3 | 11 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Hemorrhagic | 4 | 1 4.0|
Nephropathy, Chronic | 3 4 3 2 4 2 3 4 3 3 3 2 3 4 3 3 4 3 3 3 3 3 3 2 2| 50 2.9|
Renal Tubule, Degeneration | 3 | 1 3.0|
Renal Tubule, Pigmentation, | | |
Hemosiderin | 1 1 2 1 1 2 1 1 1 1 2 4 1 1 1 2 1 2 1 1 1 2 2 3 1| 49 1.4|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + + | 24 |
__________________________________________________________________________|____________|
Urethra | + + | 3 |
Inflammation, Hemorrhagic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 7 |
Dilatation | | 1 4.0|
Inflammation, Hemorrhagic | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 6| 7| 7| 6| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 5| 6| 6| 5| 5| 6|
DAY ON TEST | 2| 5| 3| 3| 7| 8| 1| 3| 2| 3| 7| 7| 2| 2| 1| 0| 2| 3| 3| 3| 2| 8| 8| 5| 8|
| 2| 4| 0| 2| 6| 6| 2| 0| 2| 1| 4| 6| 8| 8| 8| 0| 2| 0| 0| 5| 4| 6| 4| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
18 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 4 |
Inflammation, Necrotizing | 4 |
__________________________________________________________________________|
Intestine Large | + + + + A + + + A + + + + + A A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + A + + + + + A A + + + + A + + + +|
Dilatation | 2 |
Inflammation, Chronic Active | 2 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + A + + + + + A A + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + A + + + + + A A + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + A + + + + + + + + + A A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + A A + + + + + + M + +|
__________________________________________________________________________|
Intestine Small, Ileum | + M + + A + + + A + + A + + A A + + A + A + + + +|
Dilatation | 2 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + A + + + A + + A + + A A + + A + + + + + +|
Dilatation | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + A + + + + + + + + +|
Basophilic Focus | X X X X X X X X |
Clear Cell Focus | |
Degeneration, Cystic | 2 1 2 1 2|
Eosinophilic Focus | X|
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic | 1 2 2 1 |
Inflammation, Necrotizing | 2 1 2|
Necrosis, Coagulative | 2 3 3 4 |
Pigmentation, Hemosiderin | 2 2 2 2 2 1 3 2 2 2 1 1 |
Vacuolization Cytoplasmic | |
Bile Duct, Hyperplasia | 2 1 2 2 2 1 2 1 2 1 2 1 3 1 2 2 1 2 2 1 2 1|
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Inflammation, Chronic | 2 2 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Pancreas | + + + + A + + + + + + + + + + + + + + + M + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | 2 2 2 2 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + A + + + A + + + + + A A + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + A + + + + + A A + + + + + + + + +|
Acanthosis | 2 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 6| 7| 7| 6| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 5| 6| 6| 5| 5| 6|
DAY ON TEST | 2| 5| 3| 3| 7| 8| 1| 3| 2| 3| 7| 7| 2| 2| 1| 0| 2| 3| 3| 3| 2| 8| 8| 5| 8|
| 2| 4| 0| 2| 6| 6| 2| 0| 2| 1| 4| 6| 8| 8| 8| 0| 2| 0| 0| 5| 4| 6| 4| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
18 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hyperkeratosis | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + A + + + + A A + + + + + + + + +|
Necrosis, Coagulative | 3 2 |
__________________________________________________________________________|
Tongue | |
Foreign Body | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + M|
Peridontal Tissue, Foreign Body | |
Peridontal Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric Artery, Inflammation, | |
Chronic Active | 4 |
Mesenteric Artery, Necrosis, | |
Fibrinoid | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 3 2 2 2 2 2 2 2 2 2 1 2 3 2 2|
Mineralization | 1 |
Atrium, Thrombosis | X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + A + + + + + + + + +|
Degeneration, Fatty | 3 1 4 2 2 2|
Hematocyst | |
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + A + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 2 3 2 2 2 2 1|
__________________________________________________________________________|
Islets, Pancreatic | M + + + A + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + M + + M|
Craniopharyngeal Duct, Cyst | X |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + A + + A + + + A + + + + + + + + +|
Inflammation, Necrotizing | 3 |
C-Cell, Hyperplasia | 2 2 1 2 2 2 2 |
Follicular Cell, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 6| 7| 7| 6| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 5| 6| 6| 5| 5| 6|
DAY ON TEST | 2| 5| 3| 3| 7| 8| 1| 3| 2| 3| 7| 7| 2| 2| 1| 0| 2| 3| 3| 3| 2| 8| 8| 5| 8|
| 2| 4| 0| 2| 6| 6| 2| 0| 2| 1| 4| 6| 8| 8| 8| 0| 2| 0| 0| 5| 4| 6| 4| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
18 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia | 3 2|
Inflammation, Chronic Active | 3 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + M + + + + + + + + + + + +|
Abscess | 2 |
Inflammation, Chronic Active | 3 1 2 2 2 3 3 1 4 1 2 2 1 1 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + M + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Seminiferous Tubule, Atrophy | 2 3 3 3 4 3 4 3 3 4 4 4 2 4 4 4 3 4 4 3 2 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + +|
Neutrophilia | X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
Thrombosis | X |
Femoral, Hyperplasia | 3 4 3 3 4 3 4 4 3 3 4 4 4 3 4 4 4 4 3 2 4 4|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Cyst | X|
Mediastinal, Edema | |
Mediastinal, Hemorrhage, Acute | 4 |
Mediastinal, Infiltration Cellular, | |
Mast Cell | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
Mediastinal, Pigmentation, | |
Hemosiderin | |
Pancreatic, Ectopic Tissue | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
Pancreatic, Pigmentation, Hemosiderin| |
Renal, Cyst | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + +|
Cyst | X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + +|
Cyst | X |
Infiltration Cellular, Histiocyte | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 6| 7| 7| 6| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 5| 6| 6| 5| 5| 6|
DAY ON TEST | 2| 5| 3| 3| 7| 8| 1| 3| 2| 3| 7| 7| 2| 2| 1| 0| 2| 3| 3| 3| 2| 8| 8| 5| 8|
| 2| 4| 0| 2| 6| 6| 2| 0| 2| 1| 4| 6| 8| 8| 8| 0| 2| 0| 0| 5| 4| 6| 4| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
18 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Cyst | |
Fibrosis | 3 2 3 3 2 4 3 4 4 3 4 3 3 3 3 3 3 4 4|
Granuloma | 1 |
Hematopoietic Cell Proliferation | 1 2 2 1 1 4 2 3 2 1 2 1|
Infarct, Acute | |
Infiltration Cellular, Lipocyte | 2 1 3 2 3 2 3 3 2 2 1 3|
Pigmentation, Hemosiderin | 1 2 2 3 1 2 3 2 2 |
Sinusoid, Ectasia | 2 |
__________________________________________________________________________|
Thymus | + + + + A + + + + + M M M M + A M + + + + + + + M|
Cyst | X |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + + + + + + + M + + + + + M + + + M + + M M +|
Hyperplasia, Cystic | 1 2 1 2 1 3 2 2 2 4 1 1 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Hydrocephalus | 2 |
Mineralization | 2 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | |
Inflammation, Chronic | 2 1 2 |
Inflammation, Suppurative | 2 |
Alveolar Epithelium, Hyperplasia | |
Mediastinum, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Nose | + + + + A + + + + + + + + + + A + + + + + + + + M|
Inflammation, Chronic Active | |
Inflammation, Suppurative | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 6| 7| 7| 6| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 5| 6| 6| 5| 5| 6|
DAY ON TEST | 2| 5| 3| 3| 7| 8| 1| 3| 2| 3| 7| 7| 2| 2| 1| 0| 2| 3| 3| 3| 2| 8| 8| 5| 8|
| 2| 4| 0| 2| 6| 6| 2| 0| 2| 1| 4| 6| 8| 8| 8| 0| 2| 0| 0| 5| 4| 6| 4| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
18 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + + + + |
Inflammation, Chronic | |
Lens, Cataract | 3 3 3 3 3 3 3 |
Retina, Atrophy | 3 3 3 3 3 3 4 |
__________________________________________________________________________|
Harderian Gland | + + + + M + + + + + + + M + + A M + + + + + + + M|
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 2 3 3 2 2 3 2 2 2 2 1 4 2 1 3 3 2 2 2 1 2|
Renal Tubule, Pigmentation, | |
Hemosiderin | 3 2 3 3 2 3 4 2 2 2 3 2 2 3 2 2 2 2 2 2 3 2 1 3 2|
__________________________________________________________________________|
Ureter | + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Urethra | + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + M + + + + + + + M + + A + + + + + + + + +|
Dilatation | |
Inflammation, Chronic Active | 2 2 |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 4| 6| |
DAY ON TEST | 3| 3| 3| 5| 2| 3| 3| 2| 3| 3| 7| 2| 1| 2| 3| 5| 2| 2| 3| 3| 9| 1| 3| 1| 8| |
| 0| 1| 1| 9| 9| 0| 2| 9| 1| 2| 9| 1| 5| 9| 1| 9| 9| 8| 1| 2| 4| 6| 0| 5| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
18 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 4.0|
Inflammation, Necrotizing | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A| 44 |
Dilatation | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + M + + + + + + + + + + + +| 44 |
Parasite Metazoan | X X X X | 4 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + A| 39 |
Dilatation | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + +| 41 |
Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | X X X X X X X X X X X X X| 21 |
Clear Cell Focus | X X | 2 |
Degeneration, Cystic | 2 2 2 2 1 1 2 | 12 1.7|
Eosinophilic Focus | X | 2 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | X | 2 |
Inflammation, Chronic | 1 1 1 1 3 | 9 1.4|
Inflammation, Necrotizing | 1 | 4 1.5|
Necrosis, Coagulative | 3 3 3 2 3| 9 2.9|
Pigmentation, Hemosiderin | 1 2 1 2 1 1 2 1 2 1 1 1 1 1| 26 1.5|
Vacuolization Cytoplasmic | 1 | 1 1.0|
Bile Duct, Hyperplasia | 2 2 1 2 2 2 2 2 1 2 3 2 2 2 1 1 2 1 2 2 2 1 1 2 1| 47 1.7|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Ectopic Tissue | X | 1 |
Inflammation, Chronic | 1 2 2 | 5 1.8|
Pigmentation, Hemosiderin | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 |
Inflammation, Chronic | 3 | 1 3.0|
Acinus, Atrophy | 2 1 1 2 2 4 1 3 1| 13 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 4| 6| |
DAY ON TEST | 3| 3| 3| 5| 2| 3| 3| 2| 3| 3| 7| 2| 1| 2| 3| 5| 2| 2| 3| 3| 9| 1| 3| 1| 8| |
| 0| 1| 1| 9| 9| 0| 2| 9| 1| 2| 9| 1| 5| 9| 1| 9| 9| 8| 1| 2| 4| 6| 0| 5| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
18 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Acinus, Hyperplasia | 2| 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Acanthosis | | 1 2.0|
Hyperkeratosis | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Necrosis, Coagulative | 1 2 | 4 2.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
Foreign Body | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Peridontal Tissue, Foreign Body | 1 | 1 1.0|
Peridontal Tissue, Inflammation, | | |
Chronic Active | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mesenteric Artery, Inflammation, | | |
Chronic Active | | 1 4.0|
Mesenteric Artery, Necrosis, | | |
Fibrinoid | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 2 2 3 2 3 2 2 2 2 3 2 2 3 2 2 2 2 2 2 2 2 2 2 2| 42 2.1|
Mineralization | | 1 1.0|
Atrium, Thrombosis | X X X X| 8 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Fatty | 2 2 1 1 3 1 1 2 2 1| 16 1.9|
Hematocyst | X| 1 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia | 2 1 2 2 2 2 2 1 3 1 2| 17 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia | 2 2 2 2 2 2 2 1 2| 17 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + M + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + M + + M + + + + M + + + + +| 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 4| 6| |
DAY ON TEST | 3| 3| 3| 5| 2| 3| 3| 2| 3| 3| 7| 2| 1| 2| 3| 5| 2| 2| 3| 3| 9| 1| 3| 1| 8| |
| 0| 1| 1| 9| 9| 0| 2| 9| 1| 2| 9| 1| 5| 9| 1| 9| 9| 8| 1| 2| 4| 6| 0| 5| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
18 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 46 |
Craniopharyngeal Duct, Cyst | | 1 |
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia | 2 2 1 2 2 2 | 13 1.9|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + A + + + + + + + + + + + + A| 45 |
Inflammation, Necrotizing | | 1 3.0|
C-Cell, Hyperplasia | 2 2 2 2 1 1 2 1 2 1 2 2 1 1 1 1 2 | 24 1.6|
Follicular Cell, Hyperplasia | | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 3 | 3 2.7|
Inflammation, Chronic Active | 2 2 3 2 2 2 2 2 2 2 2 1 2 2 2 3 2 2 2 2 1 2| 43 2.1|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
Abscess | | 1 2.0|
Inflammation, Chronic Active | 2 2 2 2 1 2 2 2 2 2 2 2 2 2| 29 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + M + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Hyperplasia | 2 1 2 2 2 2 1 2 2 1 2 | 25 1.9|
Seminiferous Tubule, Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4| 46 3.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + + + + | 31 |
Neutrophilia | X X X X | 6 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 2.0|
Thrombosis | | 1 |
Femoral, Hyperplasia | 3 3 4 4 3 4 3 4 4 3 4 4 3 4 4 4 4 3 3 4 4 3 3 3| 46 3.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mediastinal, Cyst | X | 2 |
Mediastinal, Edema | 2 | 1 2.0|
Mediastinal, Hemorrhage, Acute | | 1 4.0|
Mediastinal, Infiltration Cellular, | | |
Mast Cell | 3 | 1 3.0|
Mediastinal, Infiltration Cellular, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 4| 6| |
DAY ON TEST | 3| 3| 3| 5| 2| 3| 3| 2| 3| 3| 7| 2| 1| 2| 3| 5| 2| 2| 3| 3| 9| 1| 3| 1| 8| |
| 0| 1| 1| 9| 9| 0| 2| 9| 1| 2| 9| 1| 5| 9| 1| 9| 9| 8| 1| 2| 4| 6| 0| 5| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
18 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Histiocyte | 3 | 1 3.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | 3 2 | 2 2.5|
Pancreatic, Ectopic Tissue | X | 1 |
Pancreatic, Infiltration Cellular, | | |
Histiocyte | 3 2 | 2 2.5|
Pancreatic, Pigmentation, Hemosiderin| 3 2 | 2 2.5|
Renal, Cyst | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | X X | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + | 10 |
Cyst | X | 2 |
Infiltration Cellular, Histiocyte | 3 | 1 3.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Fibrosis | 3 3 3 3 3 3 3 3 3 3 3 2 3 2 3 2 3 3 3 4 3 3| 41 3.0|
Granuloma | | 1 1.0|
Hematopoietic Cell Proliferation | 1 1 2 1 3 1 1 1 2 1 3 2 2 2 | 26 1.7|
Infarct, Acute | 4 | 1 4.0|
Infiltration Cellular, Lipocyte | 3 2 2 3 2 3 3 2 2 3 2 3| 24 2.4|
Pigmentation, Hemosiderin | 2 1 1 1 1 2 2 2 2 3 2 2 | 21 1.9|
Sinusoid, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + M + + + + + M + + + + + M M + + M +| 36 |
Cyst | | 1 |
Inflammation, Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + M + + + + + + + M + + M + + + + + M + + M M| 36 |
Hyperplasia, Cystic | 1 2 1 2 1 1 2 2 2 2 1 2 2 2 1 2 | 29 1.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 4| 6| |
DAY ON TEST | 3| 3| 3| 5| 2| 3| 3| 2| 3| 3| 7| 2| 1| 2| 3| 5| 2| 2| 3| 3| 9| 1| 3| 1| 8| |
| 0| 1| 1| 9| 9| 0| 2| 9| 1| 2| 9| 1| 5| 9| 1| 9| 9| 8| 1| 2| 4| 6| 0| 5| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
18 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Hydrocephalus | 3 | 2 2.5|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma | 1 | 1 1.0|
Inflammation, Chronic | 1 | 4 1.5|
Inflammation, Suppurative | 2 | 2 2.0|
Alveolar Epithelium, Hyperplasia | 3 2 | 2 2.5|
Mediastinum, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Inflammation, Chronic Active | 2 2 2 2 2 2 1 2 | 8 1.9|
Inflammation, Suppurative | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 3 | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 2 | 3 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + I + + + + + + + + + + + + + +| 49 |
Inflammation, Necrotizing | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + + + + + + + | 14 |
Inflammation, Chronic | 2 | 1 2.0|
Lens, Cataract | 3 4 3 3 3 3 | 13 3.1|
Retina, Atrophy | 3 4 3 3 3 3 | 13 3.2|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + M + + M + + + + + + + + +| 43 |
Inflammation, Chronic | 2 1 | 3 1.7|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 3 3 3 2 3 3 3 2 2 3 3 2 1 3 2 2 2 2 3 2 2 3 1 2| 46 2.3|
Renal Tubule, Pigmentation, | | |
Hemosiderin | 2 3 2 3 3 2 2 2 2 2 2 2 1 3 2 2 2 2 2 2 2 2 2 2 2| 50 2.2|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Urethra | + + + + + | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 4| 6| |
DAY ON TEST | 3| 3| 3| 5| 2| 3| 3| 2| 3| 3| 7| 2| 1| 2| 3| 5| 2| 2| 3| 3| 9| 1| 3| 1| 8| |
| 0| 1| 1| 9| 9| 0| 2| 9| 1| 2| 9| 1| 5| 9| 1| 9| 9| 8| 1| 2| 4| 6| 0| 5| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
18 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + M + + + + + + + + + + + +| 46 |
Dilatation | 4 | 1 4.0|
Inflammation, Chronic Active | | 2 2.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5|
DAY ON TEST | 6| 1| 2| 3| 2| 3| 2| 3| 3| 2| 4| 7| 1| 2| 2| 2| 3| 3| 2| 3| 3| 3| 3| 2| 7|
| 1| 6| 9| 0| 9| 0| 9| 2| 2| 9| 9| 6| 0| 9| 4| 9| 1| 1| 9| 2| 1| 1| 3| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
6 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + +|
Foreign Body | 4 |
Inflammation, Necrotizing | 3 |
__________________________________________________________________________|
Intestine Large | + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A A M +|
__________________________________________________________________________|
Intestine Large, Colon | + + A A + +|
__________________________________________________________________________|
Intestine Large, Rectum | M A + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + A + +|
Metaplasia, Osseous | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X X X X|
Degeneration, Cystic | 4 2 2 1 2 3 2 |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic | 2 1 2 2 1 2 3 2 |
Inflammation, Necrotizing | 1 1 4 |
Necrosis, Coagulative | 2 4 |
Vacuolization Cytoplasmic | 2 1 1 2 |
Bile Duct, Hyperplasia | 2 2 2 2 1 2 2 2 2 2 2 3 1 2 2 2 2 2 2 2 3 2 2 2|
__________________________________________________________________________|
Mesentery | + + + + +|
Inflammation, Chronic | 2 1 |
Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Pancreas | + + + + A + + + +|
Pigmentation, Hemosiderin | 2 |
Acinus, Atrophy | 2 1|
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + A + + + +|
__________________________________________________________________________|
Stomach | + + + A + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + +|
Acanthosis | 2 |
Hyperkeratosis | 2 |
Inflammation, Chronic Active | 4 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + +|
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Tooth | + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5|
DAY ON TEST | 6| 1| 2| 3| 2| 3| 2| 3| 3| 2| 4| 7| 1| 2| 2| 2| 3| 3| 2| 3| 3| 3| 3| 2| 7|
| 1| 6| 9| 0| 9| 0| 9| 2| 2| 9| 9| 6| 0| 9| 4| 9| 1| 1| 9| 2| 1| 1| 3| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
6 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy, Chronic | 2 2 2 2 2 3 2 2 2 2 2 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 2 1 |
Hyperplasia | 2 1 2 2 2 2 2 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia | 2 2 2 1 2 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + A + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + A + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Hemorrhage, Acute | 3|
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + A + + +|
C-Cell, Hyperplasia | 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + +|
__________________________________________________________________________|
Penis | |
Concretion | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + +|
Hyperplasia | 4 |
Inflammation, Chronic Active | 2 4 2 2 2|
__________________________________________________________________________|
Prostate | + + + + + + +|
Inflammation, Chronic Active | 4 2 2 3 2 2|
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 1 2 2 2 2 1|
Seminiferous Tubule, Atrophy | 4 4 4 4 4 4 4 4 3 3 3 4 4 4 4 4 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + + |
Neutrophilia | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Femoral, Hyperplasia | 4 2 4 3 3 3 3 4 4 3 3 4 3 3 3 3 3 4 3|
Femoral, Hyperplasia, Reticulum Cell | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5|
DAY ON TEST | 6| 1| 2| 3| 2| 3| 2| 3| 3| 2| 4| 7| 1| 2| 2| 2| 3| 3| 2| 3| 3| 3| 3| 2| 7|
| 1| 6| 9| 0| 9| 0| 9| 2| 2| 9| 9| 6| 0| 9| 4| 9| 1| 1| 9| 2| 1| 1| 3| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
6 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + +|
Mediastinal, Infiltration Cellular, | |
Mast Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + A + + + +|
Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
Cyst | |
Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 1 1 2 1 2 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 1 2 2 2 3 2 3 2 2 2 2 2 2 3 2|
Pigmentation, Hemosiderin | 1 3 3 2 3 3 3 2 3 2 2 3 2 2 2 2 2 2 2 3 2 3 1 3|
__________________________________________________________________________|
Thymus | + + + + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + +|
Hyperplasia, Cystic | 2 4 2 2 2 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + A + + +|
Compression | X X|
Hemorrhage, Acute | 4|
Hydrocephalus | 2|
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + +|
__________________________________________________________________________|
Nose | + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + +|
Inflammation, Necrotizing | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + |
Lens, Cataract | 3 3 3 3 3 3 |
Retina, Atrophy | 3 3 3 3 3 3 3 |
__________________________________________________________________________|
Harderian Gland | + + + + + M|
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5|
DAY ON TEST | 6| 1| 2| 3| 2| 3| 2| 3| 3| 2| 4| 7| 1| 2| 2| 2| 3| 3| 2| 3| 3| 3| 3| 2| 7|
| 1| 6| 9| 0| 9| 0| 9| 2| 2| 9| 9| 6| 0| 9| 4| 9| 1| 1| 9| 2| 1| 1| 3| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
6 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 4 3 2 3 2 3 3 2 4 2 2 3 2 3 3 2 3 3 3 3 3 3 2 2|
Renal Tubule, Pigmentation, | |
Hemosiderin | 1 3 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 1 1 1|
__________________________________________________________________________|
Ureter | + + + + + + + + + + + + + |
__________________________________________________________________________|
Urethra | + |
Transitional Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 3| 7| 4| 7| 4| |
DAY ON TEST | 3| 3| 3| 7| 8| 1| 3| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 1| 3| 2| 7| 3| 9| |
| 2| 2| 0| 8| 6| 8| 2| 2| 0| 1| 2| 1| 2| 2| 9| 2| 2| 0| 1| 1| 8| 9| 6| 2| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
6 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + +| 13 |
Foreign Body | 4 | 2 4.0|
Inflammation, Necrotizing | 4 | 2 3.5|
__________________________________________________________________________|____________|
Intestine Large | + + + + + +| 12 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A A A +| 6 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + +| 9 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + +| 8 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + +| 12 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + +| 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A A + A +| 6 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + A +| 8 |
Metaplasia, Osseous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 | 2 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X | 31 |
Degeneration, Cystic | 2 3 2 | 10 2.3|
Eosinophilic Focus | | 1 |
Hepatodiaphragmatic Nodule | X | 2 |
Inflammation, Chronic | 2 2 2 2 1 2 2 1 1 2 2 | 19 1.8|
Inflammation, Necrotizing | 1 2 | 5 1.8|
Necrosis, Coagulative | 2| 3 2.7|
Vacuolization Cytoplasmic | 1 1 1 2 2 | 9 1.4|
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 3| 43 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + +| 11 |
Inflammation, Chronic | | 2 1.5|
Pigmentation, Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + +| 14 |
Pigmentation, Hemosiderin | | 1 2.0|
Acinus, Atrophy | 2 | 3 1.7|
Acinus, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + +| 11 |
__________________________________________________________________________|____________|
Stomach | + + + + +| 11 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + +| 11 |
Acanthosis | | 1 2.0|
Hyperkeratosis | | 1 2.0|
Inflammation, Chronic Active | | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + +| 11 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 3| 7| 4| 7| 4| |
DAY ON TEST | 3| 3| 3| 7| 8| 1| 3| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 1| 3| 2| 7| 3| 9| |
| 2| 2| 0| 8| 6| 8| 2| 2| 0| 1| 2| 1| 2| 2| 9| 2| 2| 0| 1| 1| 8| 9| 6| 2| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
6 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | + + + +| 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + +| 12 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + +| 23 |
Cardiomyopathy, Chronic | 2 2 2 2 2 2 2 2 3 2| 22 2.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Fatty | 2 2 1 2 3 2 2 | 10 1.9|
Hyperplasia | 1 2 2 2 2 1 2 2 2 2 2 2 | 19 1.8|
Necrosis, Coagulative | 2| 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | | 1 |
Hyperplasia | 2 2 1 2 2 2 2 | 15 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + +| 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + +| 10 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + +| 19 |
Pars Distalis, Angiectasis | | 1 3.0|
Pars Distalis, Hemorrhage, Acute | | 1 3.0|
Pars Distalis, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + +| 10 |
C-Cell, Hyperplasia | 2 2| 4 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + +| 26 |
__________________________________________________________________________|____________|
Penis | +| 1 |
Concretion | 3| 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + M + + + +| 15 |
Hyperplasia | | 1 4.0|
Inflammation, Chronic Active | 2 2| 7 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + +| 13 |
Inflammation, Chronic Active | 2 1 2 2 2| 11 2.2|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + +| 5 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 3| 7| 4| 7| 4| |
DAY ON TEST | 3| 3| 3| 7| 8| 1| 3| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 1| 3| 2| 7| 3| 9| |
| 2| 2| 0| 8| 6| 8| 2| 2| 0| 1| 2| 1| 2| 2| 9| 2| 2| 0| 1| 1| 8| 9| 6| 2| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
6 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 1 1 2 2 1 2 2 2 | 23 1.8|
Seminiferous Tubule, Atrophy | 4 4 4 4 4 4 4 4 2 4 4 4 4 4 4 4 2 4 4 4 4 | 39 3.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + + + + +| 39 |
Neutrophilia | X | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 1 2.0|
Femoral, Hyperplasia | 3 3 3 4 3 3 3 3 2 3 3 2 2 4 3 4| 35 3.1|
Femoral, Hyperplasia, Reticulum Cell | 3 2 2 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + +| 15 |
Mediastinal, Infiltration Cellular, | | |
Mast Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + +| 12 |
Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 2 |
Cyst | X | 1 |
Ectasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 1 3 2 1 1 1 | 12 1.4|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 4 2 2 2 1 2 2 2 2 2 2 3 3 2 | 42 2.1|
Pigmentation, Hemosiderin | 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 1| 48 2.2|
__________________________________________________________________________|____________|
Thymus | + + + + +| 13 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + M| 13 |
Hyperplasia, Cystic | 2 2 2 | 10 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + +| 19 |
Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + +| 11 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + +| 10 |
Compression | | 2 |
Hemorrhage, Acute | | 1 4.0|
Hydrocephalus | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PARA-CHLOROANILINE Date: 05/05/97
Route: GAVAGE Time: 13:22:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 3| 7| 4| 7| 4| |
DAY ON TEST | 3| 3| 3| 7| 8| 1| 3| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 1| 3| 2| 7| 3| 9| |
| 2| 2| 0| 8| 6| 8| 2| 2| 0| 1| 2| 1| 2| 2| 9| 2| 2| 0| 1| 1| 8| 9| 6| 2| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
6 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + +| 11 |
__________________________________________________________________________|____________|
Nose | M + + + +| 10 |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + +| 13 |
Inflammation, Necrotizing | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + | 13 |
Lens, Cataract | 3 3 3 3 3 3 | 12 3.0|
Retina, Atrophy | 3 3 3 3 3 3 | 13 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + +| 9 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Nephropathy, Chronic | 3 3 3 2 4 4 3 3 3 4 2 2 3 3 3 4 2 3 4 4 2 4 3| 48 2.9|
Renal Tubule, Pigmentation, | | |
Hemosiderin | 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 1 1 2| 47 1.8|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Urethra | | 1 |
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + +| 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
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---------- END OF REPORT ----------
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