TR 351 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/03/94
EXP: 05020 PARA-CHLOROANILINE TIME: 18:21:54
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 02039B
CONT: NO1CP9565302 CAS: 000106478
PATHOLOGIST: J. TOFT S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/03/94
EXP: 05020 PARA-CHLOROANILINE TIME: 18:21:54
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 02039B
CONT: NO1CP9565302 CAS: 000106478
PATHOLOGIST: J. TOFT S. EUSTIS
PARA-CHLOROANILINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE |
| --------------------- |
| |
| TOTAL 49 UNCENSORED DEATHS 31 CENSORED DEATHS 0 TERMINAL 18 |
| |
| UNCENSORED DEATHS |
| 72 263 330 455 466 512 521 554 568 578 |
| 584 626 627 628 633 633 639 647 655 655 |
| 662 674 680 688 688 701 704 709 710 721 |
| 723 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 486 529 556 626 627 651 651 651 654 654 |
| 654 673 674 687 693 714 715 716 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 6 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 2 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 338 361 498 521 533 549 570 572 578 686 |
| 702 710 711 716 718 724 |
| CENSORED DEATHS |
| 476 476 |
| |
==================================================================================
PARA-CHLOROANILINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 18 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 28 CENSORED DEATHS 1 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 415 494 522 535 556 584 615 618 622 624 |
| 654 659 659 674 676 679 680 686 686 689 |
| 700 712 716 721 722 728 728 728 |
| CENSORED DEATHS |
| 476 |
| |
==================================================================================
PARA-CHLOROANILINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 98.0 98.0 95.9 93.9 93.9 89.8 85.7 77.6 57.1 36.7 |
| | |
| | |
|2 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 94.0 78.0 64.0 |
| | |
| | |
|6 MG/KG | 100.0 100.0 100.0 96.0 96.0 96.0 89.7 81.4 81.4 66.8 |
| | |
| | |
|18 MG/KG | 100.0 100.0 100.0 100.0 98.0 98.0 91.9 87.8 73.5 42.9 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 2 MG/KG 6 MG/KG 18 MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 36.7% 64.0% 66.8% 42.9% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.793 P=0.007N P=0.005N P=0.367N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 590.5 645.1 592.9 645.8 |
|NATURAL DEATHS (C) | (26.2) (14.9) (31.3) (15.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 641.4 698.8 675.3 677.3 |
|(STANDARD ERROR) | (19.1) ( 7.8) (14.5) (11.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PARA-CHLOROANILINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 80 189 200 209 369 400 482 519 529 537 |
| 544 557 605 612 618 630 637 658 662 701 |
| 714 722 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 140 428 605 605 617 664 688 693 716 723 |
| 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 6 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 332 520 539 553 574 581 594 605 626 629 |
| 657 701 711 721 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PARA-CHLOROANILINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 18 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 511 526 529 552 577 595 616 619 644 665 |
| 688 705 708 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PARA-CHLOROANILINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 98.0 98.0 92.0 92.0 88.0 86.0 78.0 74.0 62.0 54.0 |
| | |
| | |
|2 MG/KG | 100.0 98.0 98.0 98.0 98.0 96.0 96.0 92.0 88.0 78.0 |
| | |
| | |
|6 MG/KG | 100.0 100.0 100.0 98.0 98.0 98.0 94.0 84.0 78.0 72.0 |
| | |
| | |
|18 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 94.0 88.0 80.0 74.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 2 MG/KG 6 MG/KG 18 MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 54.0% 78.0% 72.0% 74.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.244N P=0.011N P=0.075N P=0.043N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 517.5 600.6 595.9 610.4 |
|NATURAL DEATHS (C) | (39.5) (52.8) (26.4) (19.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 631.7 700.8 691.7 698.2 |
|(STANDARD ERROR) | (23.4) (13.5) (11.2) ( 8.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PARA-CHLOROANILINE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE = 1
2 MG/KG = 2
6 MG/KG = 3
18 MG/KG = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3 4 2
| 1 1 3 3 4 24 2
| 1 1 3 1 43 324 2 2
| 1 1 3 3 4
90 + 1 1 3 34 4 2 2
| 1 1 3 3 4 4
P | 1 1 44 22
E | 1 11 44 3
R 80 + 11 4 4 3 3
C | 1 1 2 4 2 33
E | 2 2
N | 11 4 4 33
T 70 + 2 233
| 11 44 223 3
S | 11 2 2
U | 11 44
R 60 + 1 1 44
V | 1 1 4 4
I | 11 44
V | 11
A 50 + 1 1 44
L |
| 11
| 4 4
40 + 111
| 1 1
|
|
30 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 15 obs hidden.
PARA-CHLOROANILINE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE = 1
2 MG/KG = 2
6 MG/KG = 3
18 MG/KG = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 1 2 3 4
|
| 1 2 1 3 2 4 34
| 1 1 2 3 3 2
95 +
| 11 43 3
| 1 1 3 34 2 2
|
90 + 1 1 33 4 2 2
|
| 1 1 3 3 4 2 2
| 1 1 3 344
P 85 +
E | 11 3 43 4 2 2
R | 11 4 4 22
C |
E 80 + 11 3 3 4 4
N |
T | 1 1 3 4 3 2 2
| 1 1 33
S 75 +
U | 11 33 4
R | 11 3 3
V |
I 70 + 11
V |
A | 11
L | 1 1
65 +
| 1 1
| 1 1
|
60 + 11
|
| 1 1
|
55 +
| 1 1
|
|
50 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 11 obs hidden.