TR 354 Mouse Pathology Tables
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
Facility: Battelle Columbus Laboratory
Chemical CAS #: 828-00-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 5| 5| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 9| 3| 3| 2| 3| 3| 8| 0| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9|
| 1| 6| 1| 1| 4| 1| 9| 4| 3| 1| 1| 9| 1| 1| 8| 1| 1| 1| 1| 2| 2| 2| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Gallbladder | + + + + + + A A + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + M + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X X X |
Histiocytic Sarcoma | |
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + M|
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + M + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 5| 5| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 9| 3| 3| 2| 3| 3| 8| 0| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9|
| 1| 6| 1| 1| 4| 1| 9| 4| 3| 1| 1| 9| 1| 1| 8| 1| 1| 1| 1| 2| 2| 2| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa-Theca Tumor Benign | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Femoral, Hemangiosarcoma | X |
Femoral, Histiocytic Sarcoma | |
Femoral, Lymphoma Malignant | |
Histiocytic | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deep Cervical, Lymphoma Malignant | |
Histiocytic | X |
Inguinal, Lymphoma Malignant | |
Histiocytic | X X |
Lumbar, Lymphoma Malignant | |
Histiocytic | X |
Lumbar, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Histiocytic Sarcoma | |
Mediastinal, Lymphoma Malignant | |
Histiocytic | X X |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X X |
Mesenteric, Lymphoma Malignant | |
Histiocytic | X X |
Mesenteric, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 5| 5| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 9| 3| 3| 2| 3| 3| 8| 0| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9|
| 1| 6| 1| 1| 4| 1| 9| 4| 3| 1| 1| 9| 1| 1| 8| 1| 1| 1| 1| 2| 2| 2| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphocytic | X X |
Pancreatic, Lymphoma Malignant | |
Histiocytic | X |
Renal, Lymphoma Malignant Histiocytic| |
Renal, Lymphoma Malignant Lymphocytic| X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M|
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | X X X X |
__________________________________________________________________________|
Thymus | M + + M + + + M + M + M + + M + + M + + + + M + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + + M M + M + + M +|
Adenocarcinoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 5| 5| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 9| 3| 3| 2| 3| 3| 8| 0| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9|
| 1| 6| 1| 1| 4| 1| 9| 4| 3| 1| 1| 9| 1| 1| 8| 1| 1| 1| 1| 2| 2| 2| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + + M + + + M + + + + + + + + + + + + + + + + +|
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Ureter | + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | X X X X |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3| 9| 3| 3| 2| 3| 3| 6|
| 2| 2| 2| 2| 2| 2| 2| 3| 9| 3| 3| 3| 3| 3| 3| 4| 3| 3| 6| 3| 3| 2| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + M A + + A|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + A + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + + + A|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + A + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + + A + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + M + + + + + + + + A|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X X|
Hepatocellular Adenoma | X X X X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Histiocytic | X X X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + M|
Lymphoma Malignant Histiocytic | X X X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + M + +|
Lymphoma Malignant Histiocytic | X X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3| 9| 3| 3| 2| 3| 3| 6|
| 2| 2| 2| 2| 2| 2| 2| 3| 9| 3| 3| 3| 3| 3| 3| 4| 3| 3| 6| 3| 3| 2| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + M + +|
Pars Distalis, Adenoma | X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + M + + + + + + + + + + + + + + + + + + +|
Granulosa-Theca Tumor Benign | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Polyp Stromal | X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Femoral, Hemangiosarcoma | |
Femoral, Histiocytic Sarcoma | X |
Femoral, Lymphoma Malignant | |
Histiocytic | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deep Cervical, Lymphoma Malignant | |
Histiocytic | |
Inguinal, Lymphoma Malignant | |
Histiocytic | |
Lumbar, Lymphoma Malignant | |
Histiocytic | |
Lumbar, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Histiocytic Sarcoma | X |
Mediastinal, Lymphoma Malignant | |
Histiocytic | X |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | |
Mesenteric, Lymphoma Malignant | |
Histiocytic | X X |
Mesenteric, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3| 9| 3| 3| 2| 3| 3| 6|
| 2| 2| 2| 2| 2| 2| 2| 3| 9| 3| 3| 3| 3| 3| 3| 4| 3| 3| 6| 3| 3| 2| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphocytic | |
Pancreatic, Lymphoma Malignant | |
Histiocytic | X X X |
Renal, Lymphoma Malignant Histiocytic| X |
Renal, Lymphoma Malignant Lymphocytic| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M + +|
Lymphoma Malignant Histiocytic | X X X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Histiocytic Sarcoma | X |
Lymphoma Malignant Histiocytic | X X X X X X X X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Thymus | + + + + + M + + + + M M M + M M M M + + + M M + M|
Histiocytic Sarcoma | X |
Lymphoma Malignant Histiocytic | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Adenocarcinoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | |
Histiocytic Sarcoma | X |
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3| 9| 3| 3| 2| 3| 3| 6|
| 2| 2| 2| 2| 2| 2| 2| 3| 9| 3| 3| 3| 3| 3| 3| 4| 3| 3| 6| 3| 3| 2| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X X X X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Ureter | + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + M +|
Lymphoma Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Histiocytic | X X X X X X X X |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Gallbladder | | 44 |
__________________________________________________________________________|____________|
Intestine Large | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 48 |
__________________________________________________________________________|____________|
Intestine Small | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 48 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Liver | | 50 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma | | 2 |
Hepatocellular Adenoma | | 7 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Histiocytic | | 5 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Mesentery | | 41 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Pancreas | | 49 |
Lymphoma Malignant Histiocytic | | 4 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | | 48 |
Lymphoma Malignant Histiocytic | | 3 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 49 |
Squamous Cell Papilloma | | 3 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 49 |
__________________________________________________________________________|____________|
Tooth | | 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 45 |
__________________________________________________________________________|____________|
Heart | | 50 |
Histiocytic Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 49 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 49 |
__________________________________________________________________________|____________|
Pituitary Gland | | 47 |
Pars Distalis, Adenoma | | 6 |
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 49 |
Granulosa-Theca Tumor Benign | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Oviduct | | 46 |
__________________________________________________________________________|____________|
Uterus | | 50 |
Lymphoma Malignant Histiocytic | | 1 |
Polyp Stromal | | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Hemangiosarcoma | | 1 |
Femoral, Hemangiosarcoma | | 1 |
Femoral, Histiocytic Sarcoma | | 1 |
Femoral, Lymphoma Malignant | | |
Histiocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Deep Cervical, Lymphoma Malignant | | |
Histiocytic | | 1 |
Inguinal, Lymphoma Malignant | | |
Histiocytic | | 2 |
Lumbar, Lymphoma Malignant | | |
Histiocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mediastinal, Histiocytic Sarcoma | | 1 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | | 3 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | | 2 |
Mesenteric, Lymphoma Malignant | | |
Histiocytic | | 4 |
Mesenteric, Lymphoma Malignant | | |
Lymphocytic | | 2 |
Pancreatic, Lymphoma Malignant | | |
Histiocytic | | 4 |
Renal, Lymphoma Malignant Histiocytic| | 1 |
Renal, Lymphoma Malignant Lymphocytic| | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 48 |
Lymphoma Malignant Histiocytic | | 5 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Spleen | | 50 |
Hemangiosarcoma | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Histiocytic | | 10 |
Lymphoma Malignant Lymphocytic | | 4 |
__________________________________________________________________________|____________|
Thymus | | 31 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 44 |
Adenocarcinoma | | 1 |
__________________________________________________________________________|____________|
Skin | | 50 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 50 |
Lymphoma Malignant Lymphocytic | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Lymphoma Malignant Histiocytic | | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Alveolar/Bronchiolar Adenoma | | 3 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Histiocytic | | 4 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Nose | | 50 |
__________________________________________________________________________|____________|
Trachea | | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 48 |
Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Lymphoma Malignant Histiocytic | | 5 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Ureter | | 16 |
__________________________________________________________________________|____________|
Urinary Bladder | | 49 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 50 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Histiocytic | | 10 |
Lymphoma Malignant Lymphocytic | | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 6| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 0| 5| 3| 2| 8| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 3| 3|
| 1| 9| 1| 1| 1| 9| 1| 1| 2| 4| 1| 3| 0| 1| 1| 1| 2| 1| 2| 9| 2| 0| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 MG/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + |
__________________________________________________________________________|
Gallbladder | A + + A A M A |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large | + + + + + + A |
__________________________________________________________________________|
Intestine Large, Cecum | A + + + M + A |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A A |
__________________________________________________________________________|
Intestine Small | + + + + + + + A |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A A A A |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + A |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + +|
Hemangioma | |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X|
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Mesentery | + + + + + |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Squamous Cell Papilloma | X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + A |
Adenoma | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Tooth | + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 6| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 0| 5| 3| 2| 8| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 3| 3|
| 1| 9| 1| 1| 1| 9| 1| 1| 2| 4| 1| 3| 0| 1| 1| 1| 2| 1| 2| 9| 2| 0| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 MG/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M M |
Lymphoma Malignant Lymphocytic | |
Pars Distalis, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + M + + + + + + + + + |
Cystadenoma | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Oviduct | + + + + + + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
Axillary, Lymphoma Malignant | |
Lymphocytic | |
Deep Cervical, Lymphoma Malignant | |
Histiocytic | X |
Deep Cervical, Lymphoma Malignant | |
Lymphocytic | |
Lumbar, Lymphoma Malignant | |
Histiocytic | X X |
Lumbar, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Lymphoma Malignant | |
Histiocytic | X |
Mediastinal, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 6| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 0| 5| 3| 2| 8| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 3| 3|
| 1| 9| 1| 1| 1| 9| 1| 1| 2| 4| 1| 3| 0| 1| 1| 1| 2| 1| 2| 9| 2| 0| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 MG/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphocytic | X X |
Mediastinal, Osteosarcoma, | |
Metastatic, Skin | X |
Mesenteric, Lymphoma Malignant | |
Histiocytic | X X |
Mesenteric, Lymphoma Malignant | |
Lymphocytic | X X |
Mesenteric, Lymphoma Malignant Mixed | X |
Pancreatic, Lymphoma Malignant | |
Histiocytic | X |
Pancreatic, Lymphoma Malignant | |
Lymphocytic | X |
Renal, Lymphoma Malignant Histiocytic| X X |
Renal, Lymphoma Malignant Lymphocytic| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + |
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant Histiocytic | X X X |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X|
__________________________________________________________________________|
Thymus | + + M + + + + |
Lymphoma Malignant Lymphocytic | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M M + + |
__________________________________________________________________________|
Skin | + + + + + + + + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Subcutaneous Tissue, Fibrosarcoma | X X |
Subcutaneous Tissue, Osteosarcoma, | |
Metastatic, Bone | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + |
Osteosarcoma | X |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + |
Fibrosarcoma, Metastatic, Skin | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 6| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 0| 5| 3| 2| 8| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 3| 3|
| 1| 9| 1| 1| 1| 9| 1| 1| 2| 4| 1| 3| 0| 1| 1| 1| 2| 1| 2| 9| 2| 0| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 MG/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + |
Alveolar/Bronchiolar Adenoma | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X |
Osteosarcoma, Metastatic, Bone | X |
__________________________________________________________________________|
Nose | + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + M + M + + |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Ureter | + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + A |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X X X |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X X|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 3| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 8| 3| 3| 3| 3| 3| 0| 1| 3|
| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 7| 1| 5| 3| 9| 3| 3| 3| 6| 3| 1| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 MG/ | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + |
__________________________________________________________________________|
Gallbladder | A + + + A A + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + M + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + A + + |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + M + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + M + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Liver | + + + + + + + + + |
Hemangioma | X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Mesentery | + + + + + + |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Pancreas | + + + + A + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Salivary Glands | + + + + M + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + A + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + |
Adenoma | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Tooth | + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + |
Lymphoma Malignant Lymphocytic | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 3| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 8| 3| 3| 3| 3| 3| 0| 1| 3|
| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 7| 1| 5| 3| 9| 3| 3| 3| 6| 3| 1| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 MG/ | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + |
__________________________________________________________________________|
Parathyroid Gland | + M + + M M + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
Pars Distalis, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + |
Cystadenoma | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Oviduct | + + + + + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node | + + + + + + M + M |
Lymphoma Malignant Lymphocytic | X |
Axillary, Lymphoma Malignant | |
Lymphocytic | X |
Deep Cervical, Lymphoma Malignant | |
Histiocytic | |
Deep Cervical, Lymphoma Malignant | |
Lymphocytic | X |
Lumbar, Lymphoma Malignant | |
Histiocytic | |
Lumbar, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Lymphoma Malignant | |
Histiocytic | |
Mediastinal, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 3| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 8| 3| 3| 3| 3| 3| 0| 1| 3|
| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 7| 1| 5| 3| 9| 3| 3| 3| 6| 3| 1| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 MG/ | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphocytic | X X |
Mediastinal, Osteosarcoma, | |
Metastatic, Skin | |
Mesenteric, Lymphoma Malignant | |
Histiocytic | |
Mesenteric, Lymphoma Malignant | |
Lymphocytic | X X |
Mesenteric, Lymphoma Malignant Mixed | |
Pancreatic, Lymphoma Malignant | |
Histiocytic | |
Pancreatic, Lymphoma Malignant | |
Lymphocytic | X |
Renal, Lymphoma Malignant Histiocytic| |
Renal, Lymphoma Malignant Lymphocytic| X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + M |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + |
Hemangiosarcoma | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + + M + M M M |
Lymphoma Malignant Lymphocytic | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + M |
__________________________________________________________________________|
Skin | + + + + M + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Osteosarcoma, | |
Metastatic, Bone | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + |
Osteosarcoma | |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + |
Fibrosarcoma, Metastatic, Skin | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 3| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 8| 3| 3| 3| 3| 3| 0| 1| 3|
| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 7| 1| 5| 3| 9| 3| 3| 3| 6| 3| 1| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 MG/ | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + |
Alveolar/Bronchiolar Adenoma | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Nose | + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + M |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Ureter | + + |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
250 MG/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 14 |
__________________________________________________________________________|____________|
Gallbladder | | 6 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Large | | 13 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 12 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 11 |
__________________________________________________________________________|____________|
Intestine Small | | 14 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 8 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 13 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Liver | | 19 |
Hemangioma | | 1 |
Hepatocellular Carcinoma, Multiple | | 2 |
Hepatocellular Adenoma | | 3 |
Lymphoma Malignant Histiocytic | | 2 |
Lymphoma Malignant Lymphocytic | | 4 |
__________________________________________________________________________|____________|
Mesentery | | 11 |
Lymphoma Malignant Lymphocytic | | 4 |
__________________________________________________________________________|____________|
Pancreas | | 15 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 3 |
__________________________________________________________________________|____________|
Salivary Glands | | 13 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 3 |
__________________________________________________________________________|____________|
Stomach | | 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 48 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Squamous Cell Papilloma | | 3 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 12 |
Adenoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Tooth | | 14 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
250 MG/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | | 14 |
Lymphoma Malignant Lymphocytic | | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 14 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 14 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 14 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 13 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 11 |
__________________________________________________________________________|____________|
Pituitary Gland | | 19 |
Lymphoma Malignant Lymphocytic | | 1 |
Pars Distalis, Adenoma | | 4 |
__________________________________________________________________________|____________|
Thyroid Gland | | 14 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 21 |
Cystadenoma | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 3 |
__________________________________________________________________________|____________|
Oviduct | | 13 |
__________________________________________________________________________|____________|
Uterus | | 43 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Polyp Stromal | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 14 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 16 |
Lymphoma Malignant Lymphocytic | | 1 |
Axillary, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Deep Cervical, Lymphoma Malignant | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
250 MG/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Histiocytic | | 1 |
Deep Cervical, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Lumbar, Lymphoma Malignant | | |
Histiocytic | | 2 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | | 2 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | | 4 |
Mediastinal, Osteosarcoma, | | |
Metastatic, Skin | | 1 |
Mesenteric, Lymphoma Malignant | | |
Histiocytic | | 2 |
Mesenteric, Lymphoma Malignant | | |
Lymphocytic | | 4 |
Mesenteric, Lymphoma Malignant Mixed | | 1 |
Pancreatic, Lymphoma Malignant | | |
Histiocytic | | 1 |
Pancreatic, Lymphoma Malignant | | |
Lymphocytic | | 2 |
Renal, Lymphoma Malignant Histiocytic| | 2 |
Renal, Lymphoma Malignant Lymphocytic| | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 13 |
Lymphoma Malignant Histiocytic | | 2 |
Lymphoma Malignant Lymphocytic | | 4 |
__________________________________________________________________________|____________|
Spleen | | 23 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Histiocytic | | 3 |
Lymphoma Malignant Lymphocytic | | 6 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Thymus | | 9 |
Lymphoma Malignant Lymphocytic | | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 10 |
__________________________________________________________________________|____________|
Skin | | 14 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
250 MG/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | | 2 |
Subcutaneous Tissue, Fibrosarcoma | | 3 |
Subcutaneous Tissue, Osteosarcoma, | | |
Metastatic, Bone | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 14 |
Osteosarcoma | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 13 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 14 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 14 |
Alveolar/Bronchiolar Adenoma | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 4 |
Osteosarcoma, Metastatic, Bone | | 1 |
__________________________________________________________________________|____________|
Nose | | 14 |
__________________________________________________________________________|____________|
Trachea | | 14 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 11 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 14 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 4 |
__________________________________________________________________________|____________|
Ureter | | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | | 12 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
250 MG/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Lymphoma Malignant Histiocytic | | 3 |
Lymphoma Malignant Lymphocytic | | 6 |
Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 26
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 2| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 3| 8| 9| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 8| 1| 1| 1| 1| 1| 1| 2| 6| 1| 1| 1| 1| 3| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
500 MG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + + + M A + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +|
Leiomyoma | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + M + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Small | + A + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + A + + + + + + + + + + M + + + +|
Polyp Adenomatous | X |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Choriocarcinoma, Metastatic, Ovary | X |
Hepatocellular Carcinoma | X|
Hepatocellular Adenoma | X X X|
Ito Cell Tumor NOS | |
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | X |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Salivary Glands | + M + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + A + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 2| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 3| 8| 9| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 8| 1| 1| 1| 1| 1| 1| 2| 6| 1| 1| 1| 1| 3| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
500 MG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Capsule, Adenoma | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M M + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X |
__________________________________________________________________________|
Thyroid Gland | + M + + + + + + + A + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | X |
Mixed Tumor Benign | X |
Yolk Sac Carcinoma | X |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 2| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 3| 8| 9| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 8| 1| 1| 1| 1| 1| 1| 2| 6| 1| 1| 1| 1| 3| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
500 MG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Femoral, Lymphoma Malignant | |
Lymphocytic | |
Femoral, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Lymphoma Malignant | |
Histiocytic | |
Lumbar, Lymphoma Malignant | |
Lymphocytic | |
Lumbar, Lymphoma Malignant | |
Mediastinal, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
Mediastinal, Lymphoma Malignant | |
Histiocytic | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Lymphoma Malignant Mixed| X |
Mediastinal, Mesenteric, | |
Fibrosarcoma, Metastatic, Skin | |
Mesenteric, Lymphoma Malignant | |
Histiocytic | |
Mesenteric, Lymphoma Malignant | |
Lymphocytic | |
Mesenteric, Lymphoma Malignant | |
Mesenteric, Lymphoma Malignant Mixed | |
Pancreatic, Lymphoma Malignant | |
Lymphocytic | |
Pancreatic, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Histiocytic| |
Renal, Lymphoma Malignant Lymphocytic| |
Renal, Lymphoma Malignant | X |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | X |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Thymus | + + M + + + + M + M M M + + M + M + + + + + M + M|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 2| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 3| 8| 9| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 8| 1| 1| 1| 1| 1| 1| 2| 6| 1| 1| 1| 1| 3| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
500 MG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M + + + + + M M + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Adenoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basosquamous Tumor Malignant | |
Lymphoma Malignant Lymphocytic | |
Subcutaneous Tissue, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | |
Basosquamous Tumor Malignant, | |
Metastatic, Skin | |
Choriocarcinoma, Metastatic, Ovary | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | X |
Lymphoma Malignant Mixed | X X |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 2| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 3| 8| 9| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 8| 1| 1| 1| 1| 1| 1| 2| 6| 1| 1| 1| 1| 3| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
500 MG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Carcinoma | X |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | X |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Ureter | + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + M + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
Lymphoma Malignant Histiocytic | X X X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 7| 7| 7| 7| 5| 7| 6| 5| 6| 6| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 3| 5| 7| 3| 3| 3| 3| 3| 8| 3| 5| 0| 4| 5| 8| 3| 3| 3| 3| 3| 8| 7| 3| 0|
| 2| 2| 5| 4| 2| 3| 3| 3| 3| 4| 3| 3| 9| 6| 4| 8| 3| 3| 3| 4| 3| 0| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
500 MG/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + A + + + + + + + + + + + + + + + + + + + + + A|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Leiomyoma | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + + + + M + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + M + + + + + + + + + + + + + + + + + + + + + + A|
Polyp Adenomatous | |
__________________________________________________________________________|
Intestine Small, Ileum | M + + + + + + + + + + + + + A + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + M M + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Choriocarcinoma, Metastatic, Ovary | |
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X |
Ito Cell Tumor NOS | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X X X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X X X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Stomach | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + M + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + M + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 7| 7| 7| 7| 5| 7| 6| 5| 6| 6| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 3| 5| 7| 3| 3| 3| 3| 3| 8| 3| 5| 0| 4| 5| 8| 3| 3| 3| 3| 3| 8| 7| 3| 0|
| 2| 2| 5| 4| 2| 3| 3| 3| 3| 4| 3| 3| 9| 6| 4| 8| 3| 3| 3| 4| 3| 0| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
500 MG/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Capsule, Adenoma | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + I + + M + +|
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + +|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant | X|
Mixed Tumor Benign | |
Yolk Sac Carcinoma | |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 7| 7| 7| 7| 5| 7| 6| 5| 6| 6| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 3| 5| 7| 3| 3| 3| 3| 3| 8| 3| 5| 0| 4| 5| 8| 3| 3| 3| 3| 3| 8| 7| 3| 0|
| 2| 2| 5| 4| 2| 3| 3| 3| 3| 4| 3| 3| 9| 6| 4| 8| 3| 3| 3| 4| 3| 0| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
500 MG/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Femoral, Lymphoma Malignant | |
Lymphocytic | X X |
Femoral, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Lymphoma Malignant | |
Histiocytic | X |
Lumbar, Lymphoma Malignant | |
Lymphocytic | X |
Lumbar, Lymphoma Malignant | X|
Mediastinal, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
Mediastinal, Lymphoma Malignant | |
Histiocytic | X |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X X X |
Mediastinal, Lymphoma Malignant Mixed| X |
Mediastinal, Mesenteric, | |
Fibrosarcoma, Metastatic, Skin | X |
Mesenteric, Lymphoma Malignant | |
Histiocytic | X |
Mesenteric, Lymphoma Malignant | |
Lymphocytic | X X X |
Mesenteric, Lymphoma Malignant | X|
Mesenteric, Lymphoma Malignant Mixed | X |
Pancreatic, Lymphoma Malignant | |
Lymphocytic | X |
Pancreatic, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Histiocytic| X |
Renal, Lymphoma Malignant Lymphocytic| X X |
Renal, Lymphoma Malignant | X|
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant | X|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X X X X |
Lymphoma Malignant | X|
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Thymus | + M + + + M + M + M M + M + M + + M + M + + M + +|
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 7| 7| 7| 7| 5| 7| 6| 5| 6| 6| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 3| 5| 7| 3| 3| 3| 3| 3| 8| 3| 5| 0| 4| 5| 8| 3| 3| 3| 3| 3| 8| 7| 3| 0|
| 2| 2| 5| 4| 2| 3| 3| 3| 3| 4| 3| 3| 9| 6| 4| 8| 3| 3| 3| 4| 3| 0| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
500 MG/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + M + M + + + + M + + M M + + + + + +|
Adenocarcinoma | X |
Adenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + |
Basosquamous Tumor Malignant | X |
Lymphoma Malignant Lymphocytic | X |
Subcutaneous Tissue, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X |
Basosquamous Tumor Malignant, | |
Metastatic, Skin | X |
Choriocarcinoma, Metastatic, Ovary | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X X X X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 7| 7| 7| 7| 5| 7| 6| 5| 6| 6| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 3| 5| 7| 3| 3| 3| 3| 3| 8| 3| 5| 0| 4| 5| 8| 3| 3| 3| 3| 3| 8| 7| 3| 0|
| 2| 2| 5| 4| 2| 3| 3| 3| 3| 4| 3| 3| 9| 6| 4| 8| 3| 3| 3| 4| 3| 0| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
500 MG/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Carcinoma | |
Lymphoma Malignant Lymphocytic | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X X X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Ureter | + + + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X X X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X|
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | X X X X X |
Lymphoma Malignant Mixed | X X X |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
500 MG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Gallbladder | | 45 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Large | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 48 |
Leiomyoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 44 |
__________________________________________________________________________|____________|
Intestine Small | | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 45 |
Polyp Adenomatous | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 45 |
__________________________________________________________________________|____________|
Liver | | 50 |
Choriocarcinoma, Metastatic, Ovary | | 1 |
Hepatocellular Carcinoma | | 1 |
Hepatocellular Adenoma | | 4 |
Ito Cell Tumor NOS | | 1 |
Lymphoma Malignant Histiocytic | | 3 |
Lymphoma Malignant Lymphocytic | | 4 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________|____________|
Mesentery | | 49 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 4 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 49 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________|____________|
Salivary Glands | | 49 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Stomach | | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
500 MG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 48 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 1 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 48 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Tooth | | 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 45 |
__________________________________________________________________________|____________|
Heart | | 50 |
Lymphoma Malignant Lymphocytic | | 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Capsule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Lymphoma Malignant Lymphocytic | | 1 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 47 |
__________________________________________________________________________|____________|
Pituitary Gland | | 45 |
Pars Distalis, Adenoma | | 6 |
__________________________________________________________________________|____________|
Thyroid Gland | | 47 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 50 |
Cystadenoma | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
500 MG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Mixed Tumor Benign | | 1 |
Yolk Sac Carcinoma | | 1 |
__________________________________________________________________________|____________|
Oviduct | | 47 |
__________________________________________________________________________|____________|
Uterus | | 50 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Femoral, Lymphoma Malignant | | |
Lymphocytic | | 2 |
Femoral, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Lumbar, Lymphoma Malignant | | |
Histiocytic | | 1 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Lumbar, Lymphoma Malignant | | 1 |
Mediastinal, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | | 3 |
Mediastinal, Lymphoma Malignant Mixed| | 2 |
Mediastinal, Mesenteric, | | |
Fibrosarcoma, Metastatic, Skin | | 1 |
Mesenteric, Lymphoma Malignant | | |
Histiocytic | | 1 |
Mesenteric, Lymphoma Malignant | | |
Lymphocytic | | 3 |
Mesenteric, Lymphoma Malignant | | 1 |
Mesenteric, Lymphoma Malignant Mixed | | 1 |
Pancreatic, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Pancreatic, Lymphoma Malignant Mixed | | 1 |
Renal, Lymphoma Malignant Histiocytic| | 1 |
Renal, Lymphoma Malignant Lymphocytic| | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 39
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
500 MG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Lymphoma Malignant | | 2 |
Renal, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 49 |
Lymphoma Malignant Histiocytic | | 2 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Mixed | | 5 |
__________________________________________________________________________|____________|
Spleen | | 50 |
Lymphoma Malignant Histiocytic | | 3 |
Lymphoma Malignant Lymphocytic | | 5 |
Lymphoma Malignant | | 2 |
Lymphoma Malignant Mixed | | 6 |
__________________________________________________________________________|____________|
Thymus | | 31 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 40 |
Adenocarcinoma | | 2 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Skin | | 49 |
Basosquamous Tumor Malignant | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 50 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Alveolar/Bronchiolar Adenoma | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
500 MG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Basosquamous Tumor Malignant, | | |
Metastatic, Skin | | 1 |
Choriocarcinoma, Metastatic, Ovary | | 1 |
Lymphoma Malignant Histiocytic | | 2 |
Lymphoma Malignant Lymphocytic | | 5 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Mixed | | 3 |
Mediastinum, Alveolar/Bronchiolar | | |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Nose | | 50 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
__________________________________________________________________________|____________|
Harderian Gland | | 50 |
Adenoma | | 1 |
Carcinoma | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Lymphoma Malignant Histiocytic | | 2 |
Lymphoma Malignant Lymphocytic | | 4 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________|____________|
Ureter | | 16 |
__________________________________________________________________________|____________|
Urinary Bladder | | 49 |
Lymphoma Malignant Lymphocytic | | 4 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 50 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 2 |
Lymphoma Malignant Histiocytic | | 5 |
Lymphoma Malignant Lymphocytic | | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 41
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
500 MG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Lymphoma Malignant Mixed | | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 1|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 8| 3| 4| 0| 3| 3| 3| 3| 3| 2| 1| 6| 3| 1| 3| 3| 3| 3| 0|
| 1| 1| 1| 1| 1| 1| 9| 1| 9| 9| 1| 1| 1| 1| 2| 9| 6| 4| 2| 9| 2| 2| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + M|
Adenocarcinoma, Metastatic, | |
Uncertain Primary Site | |
__________________________________________________________________________|
Gallbladder | M + + + + + M + + A + + + + + + A + + + + + + + M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + M + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + M + + + + + + + M|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + M + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + +|
Lymphoma Malignant Mixed | |
Lymphoid Tissue, Lymphoma Malignant | |
Histiocytic | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + M|
Cholangiocarcinoma | |
Hemangiosarcoma, Multiple | X X |
Hepatocellular Carcinoma | X X X X X X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant | |
Sarcoma | X |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + |
Carcinosarcoma, Metastatic, | |
Uncertain Primary Site | |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + A + + + + + + + M|
Adenocarcinoma, Metastatic, | |
Uncertain Primary Site | |
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + A + + + + + + + M|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + A + + + + + + + M|
Squamous Cell Papilloma | X |
Squamous Cell Papilloma, Multiple | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + + + + + M|
Adenocarcinoma | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 1|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 8| 3| 4| 0| 3| 3| 3| 3| 3| 2| 1| 6| 3| 1| 3| 3| 3| 3| 0|
| 1| 1| 1| 1| 1| 1| 9| 1| 9| 9| 1| 1| 1| 1| 2| 9| 6| 4| 2| 9| 2| 2| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + M|
Adenocarcinoma, Metastatic, | |
Uncertain Primary Site | |
Carcinosarcoma, Metastatic, | |
Uncertain Primary Site | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, | |
Uncertain Primary Site | |
Adenoma | X |
Capsule, Adenoma | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + + + + + + + M|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + M + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + M|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ductus Deferens | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + |
__________________________________________________________________________|
Preputial Gland | + + + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + M + + + + + + + + + M M + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hemangiosarcoma | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Lymphoma Malignant | |
Histiocytic | X |
Mediastinal, Sarcoma, Metastatic, | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 1|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 8| 3| 4| 0| 3| 3| 3| 3| 3| 2| 1| 6| 3| 1| 3| 3| 3| 3| 0|
| 1| 1| 1| 1| 1| 1| 9| 1| 9| 9| 1| 1| 1| 1| 2| 9| 6| 4| 2| 9| 2| 2| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Uncertain Primary Site | X |
Mesenteric, Lymphoma Malignant | |
Histiocytic | X |
Mesenteric, Lymphoma Malignant | |
Lymphocytic | X |
Mesenteric, Lymphoma Malignant Mixed | |
Pancreatic, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Lymphocytic| X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M|
Adenocarcinoma, Metastatic, | |
Uncertain Primary Site | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + M|
Adenocarcinoma, Metastatic, | |
Uncertain Primary Site | |
Hemangiosarcoma | |
Lymphoma Malignant Histiocytic | X X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + + + M M + + M M M M + + + M + + + + M + M + M M|
Lymphoma Malignant Lymphocytic | X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M + M M M + M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | X X X X X |
Subcutaneous Tissue, Fibrosarcoma, | |
Multiple | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 1|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 8| 3| 4| 0| 3| 3| 3| 3| 3| 2| 1| 6| 3| 1| 3| 3| 3| 3| 0|
| 1| 1| 1| 1| 1| 1| 9| 1| 9| 9| 1| 1| 1| 1| 2| 9| 6| 4| 2| 9| 2| 2| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + M|
Adenocarcinoma, Metastatic, | |
Uncertain Primary Site | |
Alveolar/Bronchiolar Adenoma | X X |
Carcinosarcoma, Metastatic, | |
Uncertain Primary Site | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + I + + + + + + + + + + + + + + M|
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, | |
Uncertain Primary Site | |
Adenoma | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Ureter | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Urethra | + + + + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + M + + + + + + + + + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Lymphoma Malignant Histiocytic | X X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 5| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 0| 3| 2| 3| 3| 3| 6| 4| 3| 3| 2| 3| 3| 3| 4| 3| 3| 8| 3| 3|
| 2| 2| 2| 5| 2| 0| 2| 4| 3| 3| 3| 6| 9| 3| 3| 0| 3| 3| 3| 2| 3| 3| 4| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, | |
Uncertain Primary Site | X |
__________________________________________________________________________|
Gallbladder | + + + A + + + + + + + A M M + M + + + A + M A A +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + M + + + + + + + + + + + A + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + M + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + M + + + + + A + + + + + + M + +|
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + M + + + + + + + + + A + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + M + + + + + + + + + A + + + + + + A + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + A + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Lymphoid Tissue, Lymphoma Malignant | |
Histiocytic | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangiocarcinoma | X |
Hemangiosarcoma, Multiple | X |
Hepatocellular Carcinoma | X X X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant | X |
Sarcoma | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + +|
Carcinosarcoma, Metastatic, | |
Uncertain Primary Site | X |
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, | |
Uncertain Primary Site | X |
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
Squamous Cell Papilloma, Multiple | X |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 5| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 0| 3| 2| 3| 3| 3| 6| 4| 3| 3| 2| 3| 3| 3| 4| 3| 3| 8| 3| 3|
| 2| 2| 2| 5| 2| 0| 2| 4| 3| 3| 3| 6| 9| 3| 3| 0| 3| 3| 3| 2| 3| 3| 4| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, | |
Uncertain Primary Site | X |
Carcinosarcoma, Metastatic, | |
Uncertain Primary Site | X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, | |
Uncertain Primary Site | X |
Adenoma | |
Capsule, Adenoma | X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + M + M + + + + + + M M + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Ductus Deferens | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + M + + + + M + + M + + + M + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hemangiosarcoma | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Lymphoma Malignant | |
Histiocytic | |
Mediastinal, Sarcoma, Metastatic, | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 5| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 0| 3| 2| 3| 3| 3| 6| 4| 3| 3| 2| 3| 3| 3| 4| 3| 3| 8| 3| 3|
| 2| 2| 2| 5| 2| 0| 2| 4| 3| 3| 3| 6| 9| 3| 3| 0| 3| 3| 3| 2| 3| 3| 4| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Uncertain Primary Site | |
Mesenteric, Lymphoma Malignant | |
Histiocytic | X |
Mesenteric, Lymphoma Malignant | |
Lymphocytic | |
Mesenteric, Lymphoma Malignant Mixed | X |
Pancreatic, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Lymphocytic| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M + +|
Adenocarcinoma, Metastatic, | |
Uncertain Primary Site | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, | |
Uncertain Primary Site | X |
Hemangiosarcoma | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + + + M + M + + + M + M M M M M + M + M + + M M +|
Lymphoma Malignant Lymphocytic | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M + M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibroma | X X |
Subcutaneous Tissue, Fibrosarcoma | X X X |
Subcutaneous Tissue, Fibrosarcoma, | |
Multiple | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 5| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 0| 3| 2| 3| 3| 3| 6| 4| 3| 3| 2| 3| 3| 3| 4| 3| 3| 8| 3| 3|
| 2| 2| 2| 5| 2| 0| 2| 4| 3| 3| 3| 6| 9| 3| 3| 0| 3| 3| 3| 2| 3| 3| 4| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, | |
Uncertain Primary Site | X |
Alveolar/Bronchiolar Adenoma | X X X X X X |
Carcinosarcoma, Metastatic, | |
Uncertain Primary Site | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, | |
Uncertain Primary Site | X |
Adenoma | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Ureter | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urethra | + + + + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + A + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 49 |
Adenocarcinoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
__________________________________________________________________________|____________|
Gallbladder | | 36 |
__________________________________________________________________________|____________|
Intestine Large | | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 45 |
__________________________________________________________________________|____________|
Intestine Small | | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 44 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 47 |
Lymphoma Malignant Mixed | | 1 |
Lymphoid Tissue, Lymphoma Malignant | | |
Histiocytic | | 2 |
__________________________________________________________________________|____________|
Liver | | 49 |
Cholangiocarcinoma | | 1 |
Hemangiosarcoma, Multiple | | 3 |
Hepatocellular Carcinoma | | 9 |
Hepatocellular Adenoma | | 6 |
Hepatocellular Adenoma, Multiple | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant | | 1 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 41 |
Carcinosarcoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 48 |
Adenocarcinoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Lymphoma Malignant Histiocytic | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | | 49 |
__________________________________________________________________________|____________|
Stomach | | 47 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 47 |
Squamous Cell Papilloma | | 1 |
Squamous Cell Papilloma, Multiple | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 51
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Adenocarcinoma | | 1 |
__________________________________________________________________________|____________|
Tooth | | 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 43 |
__________________________________________________________________________|____________|
Heart | | 49 |
Adenocarcinoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Carcinosarcoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Adenocarcinoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Adenoma | | 1 |
Capsule, Adenoma | | 5 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Pheochromocytoma Benign | | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 48 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 41 |
__________________________________________________________________________|____________|
Pituitary Gland | | 46 |
__________________________________________________________________________|____________|
Thyroid Gland | | 49 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 45 |
__________________________________________________________________________|____________|
Ductus Deferens | | 47 |
__________________________________________________________________________|____________|
Epididymis | | 50 |
__________________________________________________________________________|____________|
Penis | | 2 |
__________________________________________________________________________|____________|
Preputial Gland | | 6 |
__________________________________________________________________________|____________|
Prostate | | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 52
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | | 43 |
__________________________________________________________________________|____________|
Testes | | 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Femoral, Hemangiosarcoma | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | | 1 |
Mediastinal, Sarcoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Mesenteric, Lymphoma Malignant | | |
Histiocytic | | 2 |
Mesenteric, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mesenteric, Lymphoma Malignant Mixed | | 1 |
Pancreatic, Lymphoma Malignant Mixed | | 1 |
Renal, Lymphoma Malignant Lymphocytic| | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 48 |
Adenocarcinoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Spleen | | 49 |
Adenocarcinoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Histiocytic | | 4 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Thymus | | 27 |
Lymphoma Malignant Lymphocytic | | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 53
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | | 50 |
Subcutaneous Tissue, Fibroma | | 2 |
Subcutaneous Tissue, Fibrosarcoma | | 8 |
Subcutaneous Tissue, Fibrosarcoma, | | |
Multiple | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 49 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 49 |
Adenocarcinoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Alveolar/Bronchiolar Adenoma | | 8 |
Carcinosarcoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 3 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant | | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Nose | | 49 |
__________________________________________________________________________|____________|
Trachea | | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 48 |
Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Adenocarcinoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 54
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Adenoma | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Ureter | | 41 |
__________________________________________________________________________|____________|
Urethra | | 23 |
__________________________________________________________________________|____________|
Urinary Bladder | | 47 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 50 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Histiocytic | | 4 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 55
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| 6| 7| 7| 7| 2|
DAY ON TEST | 3| 3| 7| 3| 3| 0| 8| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2| 1| 3| 3| 3| 8|
| 1| 1| 8| 1| 1| 9| 2| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 5| 3| 2| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 MG/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Gallbladder | M + + + + + A A A|
__________________________________________________________________________|
Intestine Large | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + M + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A|
__________________________________________________________________________|
Intestine Small | A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | |
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X X X X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Mesentery | + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Pancreas | + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + M|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + +|
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| 6| 7| 7| 7| 2|
DAY ON TEST | 3| 3| 7| 3| 3| 0| 8| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2| 1| 3| 3| 3| 8|
| 1| 1| 8| 1| 1| 9| 2| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 5| 3| 2| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 MG/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + +|
__________________________________________________________________________|
Ductus Deferens | + + + + + + +|
__________________________________________________________________________|
Epididymis | + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Penis | + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Testes | + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + M + + + + + + +|
Axillary, Fibrosarcoma, Metastatic, | |
Skin | X |
Inguinal, Fibrosarcoma, Metastatic, | |
Skin | |
Mesenteric, Lymphoma Malignant | |
Lymphocytic | |
Pancreatic, Lymphoma Malignant | |
Histiocytic | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | |
Hemangiosarcoma | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Thymus | + + M + M M + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | X X X X |
Subcutaneous Tissue, Fibrosarcoma, | |
Multiple | |
Subcutaneous Tissue, Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| 6| 7| 7| 7| 2|
DAY ON TEST | 3| 3| 7| 3| 3| 0| 8| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2| 1| 3| 3| 3| 8|
| 1| 1| 8| 1| 1| 9| 2| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 5| 3| 2| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 MG/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Fibrosarcoma, Metastatic, Skin | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Nose | + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + M + +|
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Ureter | + + + + + + + + +|
__________________________________________________________________________|
Urethra | + + + + +|
Transitional Epithelium, Carcinoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 6| 4| 1| 0| 6| 6| 5| 5| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 0| 7| 6| 5| 7| 4|
DAY ON TEST | 3| 0| 4| 0| 3| 6| 8| 4| 5| 3| 3| 3| 3| 3| 3| 3| 8| 6| 3| 0| 3| 7| 5| 3| 5|
| 2| 5| 6| 2| 0| 7| 8| 9| 5| 3| 3| 3| 3| 3| 7| 3| 9| 2| 3| 3| 3| 5| 1| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
250 MG/ | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + |
Fibrosarcoma, Metastatic, Skin | X |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Gallbladder | + + + + + + + + A + A + + |
__________________________________________________________________________|
Intestine Large | + A + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + A + M + + + + A + A + + |
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + A + M + + + + A + + + + |
__________________________________________________________________________|
Intestine Small | + A + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + A + M + + + + A + A + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + M + + + + + + + + + + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + |
Fibrosarcoma, Metastatic, Skin | X |
Hemangiosarcoma | |
Hepatocellular Carcinoma | X X X |
Hepatocellular Carcinoma, Multiple | X X |
Hepatocellular Adenoma | X X X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + |
Fibrosarcoma, Metastatic, Skin | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + A + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + + + + |
Squamous Cell Papilloma | X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A + + + + |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + A + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + M + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 6| 4| 1| 0| 6| 6| 5| 5| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 0| 7| 6| 5| 7| 4|
DAY ON TEST | 3| 0| 4| 0| 3| 6| 8| 4| 5| 3| 3| 3| 3| 3| 3| 3| 8| 6| 3| 0| 3| 7| 5| 3| 5|
| 2| 5| 6| 2| 0| 7| 8| 9| 5| 3| 3| 3| 3| 3| 7| 3| 9| 2| 3| 3| 3| 5| 1| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
250 MG/ | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + |
__________________________________________________________________________|
Ductus Deferens | + + + + + + + + + + + + + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + |
Fibrosarcoma, Metastatic, Skin | X |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + |
Fibrosarcoma, Metastatic, Skin | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + |
Axillary, Fibrosarcoma, Metastatic, | |
Skin | |
Inguinal, Fibrosarcoma, Metastatic, | |
Skin | X |
Mesenteric, Lymphoma Malignant | |
Lymphocytic | X |
Pancreatic, Lymphoma Malignant | |
Histiocytic | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + |
Fibrosarcoma, Metastatic, Skin | X |
Hemangiosarcoma | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Thymus | M + + + M + M + + M + M + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + |
Subcutaneous Tissue, Fibrosarcoma | X X X X X |
Subcutaneous Tissue, Fibrosarcoma, | |
Multiple | X |
Subcutaneous Tissue, Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 6| 4| 1| 0| 6| 6| 5| 5| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 0| 7| 6| 5| 7| 4|
DAY ON TEST | 3| 0| 4| 0| 3| 6| 8| 4| 5| 3| 3| 3| 3| 3| 3| 3| 8| 6| 3| 0| 3| 7| 5| 3| 5|
| 2| 5| 6| 2| 0| 7| 8| 9| 5| 3| 3| 3| 3| 3| 7| 3| 9| 2| 3| 3| 3| 5| 1| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
250 MG/ | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + |
Fibrosarcoma, Metastatic, Skin | X X X |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Fibrosarcoma, Metastatic, Skin | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + I + + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + |
Fibrosarcoma, Metastatic, Skin | X |
__________________________________________________________________________|
Ureter | + + + + + + + + + + + + |
__________________________________________________________________________|
Urethra | + + + + + + + + + + |
Transitional Epithelium, Carcinoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
250 MG/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 21 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Gallbladder | | 16 |
__________________________________________________________________________|____________|
Intestine Large | | 19 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 15 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 19 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 16 |
__________________________________________________________________________|____________|
Intestine Small | | 20 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 18 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 16 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 19 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Liver | | 28 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma | | 8 |
Hepatocellular Carcinoma, Multiple | | 2 |
Hepatocellular Adenoma | | 5 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 19 |
Fibrosarcoma, Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 20 |
__________________________________________________________________________|____________|
Salivary Glands | | 21 |
__________________________________________________________________________|____________|
Stomach | | 47 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 47 |
Squamous Cell Papilloma | | 3 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 20 |
__________________________________________________________________________|____________|
Tooth | | 20 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 21 |
__________________________________________________________________________|____________|
Heart | | 21 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 21 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 21 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 21 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 62
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
250 MG/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 19 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 19 |
__________________________________________________________________________|____________|
Pituitary Gland | | 20 |
Pars Distalis, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | | 22 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 20 |
__________________________________________________________________________|____________|
Ductus Deferens | | 20 |
__________________________________________________________________________|____________|
Epididymis | | 21 |
Fibrosarcoma, Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Penis | | 4 |
__________________________________________________________________________|____________|
Preputial Gland | | 6 |
__________________________________________________________________________|____________|
Prostate | | 21 |
__________________________________________________________________________|____________|
Seminal Vesicle | | 20 |
Fibrosarcoma, Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Testes | | 21 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 21 |
__________________________________________________________________________|____________|
Lymph Node | | 24 |
Axillary, Fibrosarcoma, Metastatic, | | |
Skin | | 1 |
Inguinal, Fibrosarcoma, Metastatic, | | |
Skin | | 1 |
Mesenteric, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Pancreatic, Lymphoma Malignant | | |
Histiocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 20 |
__________________________________________________________________________|____________|
Spleen | | 26 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 63
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
250 MG/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | | 12 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | |
__________________________________________________________________________|____________|
Skin | | 33 |
Subcutaneous Tissue, Fibrosarcoma | | 9 |
Subcutaneous Tissue, Fibrosarcoma, | | |
Multiple | | 1 |
Subcutaneous Tissue, Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 30 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 21 |
Fibrosarcoma, Metastatic, Skin | | 3 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 21 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 25 |
Alveolar/Bronchiolar Adenoma | | 2 |
Alveolar/Bronchiolar Carcinoma | | 2 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 3 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Nose | | 21 |
__________________________________________________________________________|____________|
Trachea | | 21 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 25 |
Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 23 |
Fibrosarcoma, Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Ureter | | 21 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 64
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
250 MG/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urethra | | 15 |
Transitional Epithelium, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | | 21 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 48 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 65
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 6| 6| 6| 5| 6| 5| 7| 6| 6| 7| 7| 7| 6| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 6| 6| 6| 7| 4| 5| 3| 9| 9| 3| 3| 3| 8| 3| 3| 6| 6| 2|
| 1| 1| 1| 1| 1| 0| 1| 8| 8| 8| 6| 6| 1| 1| 7| 5| 1| 1| 1| 8| 2| 2| 9| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 MG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
__________________________________________________________________________|
Gallbladder | + + + + + A + + + + + + + + + + + + + + + + A M M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + + + + + + + + + + + + + + + + + A A|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + M + M A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + A A|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + A A|
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Hemangiosarcoma | |
Hemangiosarcoma, Multiple | X |
Hepatocellular Carcinoma | X X|
Hepatocellular Adenoma | X X X X X X X |
Hepatocellular Adenoma, Multiple | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | X |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Hemangiosarcoma | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | X |
Squamous Cell Papilloma | X X X X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 6| 6| 6| 5| 6| 5| 7| 6| 6| 7| 7| 7| 6| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 6| 6| 6| 7| 4| 5| 3| 9| 9| 3| 3| 3| 8| 3| 3| 6| 6| 2|
| 1| 1| 1| 1| 1| 0| 1| 8| 8| 8| 6| 6| 1| 1| 7| 5| 1| 1| 1| 8| 2| 2| 9| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 MG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Capsule, Adenoma | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + I + + + + + M + + + M + + M + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma, Metastatic, | |
Stomach | X |
__________________________________________________________________________|
Ductus Deferens | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Epididymis | M M + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma, Metastatic, | |
Stomach | X |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma, Metastatic, | |
Stomach | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hemangiosarcoma | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Alveolar/Bronchiolar | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 6| 6| 6| 5| 6| 5| 7| 6| 6| 7| 7| 7| 6| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 6| 6| 6| 7| 4| 5| 3| 9| 9| 3| 3| 3| 8| 3| 3| 6| 6| 2|
| 1| 1| 1| 1| 1| 0| 1| 8| 8| 8| 6| 6| 1| 1| 7| 5| 1| 1| 1| 8| 2| 2| 9| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 MG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Carcinoma, Metastatic, Lung | X |
Mesenteric, Lymphoma Malignant | |
Histiocytic | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Hemangioma | X |
Hemangiosarcoma | |
Lymphoma Malignant Histiocytic | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | X |
__________________________________________________________________________|
Thymus | + M + + M + + M + M + M + + + + + + M M M + M M M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + M + + + +|
Subcutaneous Tissue, Fibroma | X X |
Subcutaneous Tissue, Fibrosarcoma | X X X X |
Subcutaneous Tissue, Hemangiosarcoma | |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + +|
Diaphragm, Squamous Cell Carcinoma, | |
Metastatic, Stomach | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | X X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 6| 6| 6| 5| 6| 5| 7| 6| 6| 7| 7| 7| 6| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 6| 6| 6| 7| 4| 5| 3| 9| 9| 3| 3| 3| 8| 3| 3| 6| 6| 2|
| 1| 1| 1| 1| 1| 0| 1| 8| 8| 8| 6| 6| 1| 1| 7| 5| 1| 1| 1| 8| 2| 2| 9| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 MG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | X |
__________________________________________________________________________|
Ureter | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urethra | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 1| 7| 7| 7| 7| 7| 7| 6| 7| 6| 4|
DAY ON TEST | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 1| 0| 3| 2| 3| 2| 9|
| 9| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 5| 4| 3| 8| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 MG/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
__________________________________________________________________________|
Gallbladder | + + M + + + + + + M + + + A A + + + A M + + + A +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + M + + + + A A + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A A + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + + + + + M + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + A A + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + M M + + + A A + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A A + + + A A + + + + +|
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Hemangiosarcoma | X |
Hemangiosarcoma, Multiple | |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | X X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Hemangiosarcoma | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + A + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 1| 7| 7| 7| 7| 7| 7| 6| 7| 6| 4|
DAY ON TEST | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 1| 0| 3| 2| 3| 2| 9|
| 9| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 5| 4| 3| 8| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 MG/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Capsule, Adenoma | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + M + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + M + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + M + + + + + M + + M + M +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
__________________________________________________________________________|
Ductus Deferens | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + M|
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + M|
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + M + + + + + + + + + + M|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hemangiosarcoma | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + M + + + +|
Bronchial, Alveolar/Bronchiolar | |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 1| 7| 7| 7| 7| 7| 7| 6| 7| 6| 4|
DAY ON TEST | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 1| 0| 3| 2| 3| 2| 9|
| 9| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 5| 4| 3| 8| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 MG/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Carcinoma, Metastatic, Lung | |
Mesenteric, Lymphoma Malignant | |
Histiocytic | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Hemangioma | X |
Hemangiosarcoma | X |
Lymphoma Malignant Histiocytic | X X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
__________________________________________________________________________|
Thymus | M M M M M + M M + M M + + + + M M + + M M M + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibroma | X X |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Hemangiosarcoma | X |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diaphragm, Squamous Cell Carcinoma, | |
Metastatic, Stomach | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 1| 7| 7| 7| 7| 7| 7| 6| 7| 6| 4|
DAY ON TEST | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 1| 0| 3| 2| 3| 2| 9|
| 9| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 5| 4| 3| 8| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 MG/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
__________________________________________________________________________|
Ureter | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urethra | + + + + + + + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + A + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X X |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
500 MG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
__________________________________________________________________________|____________|
Gallbladder | | 39 |
__________________________________________________________________________|____________|
Intestine Large | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 44 |
__________________________________________________________________________|____________|
Intestine Small | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 44 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 44 |
Lymphoma Malignant Histiocytic | | 2 |
__________________________________________________________________________|____________|
Liver | | 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Hemangiosarcoma | | 1 |
Hemangiosarcoma, Multiple | | 1 |
Hepatocellular Carcinoma | | 6 |
Hepatocellular Adenoma | | 11 |
Hepatocellular Adenoma, Multiple | | 2 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 48 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Hemangiosarcoma | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 49 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 74
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
500 MG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Squamous Cell Carcinoma | | 1 |
Squamous Cell Papilloma | | 7 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Tooth | | 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 47 |
__________________________________________________________________________|____________|
Heart | | 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Capsule, Adenoma | | 3 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 45 |
__________________________________________________________________________|____________|
Pituitary Gland | | 41 |
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 49 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach | | 1 |
__________________________________________________________________________|____________|
Ductus Deferens | | 43 |
__________________________________________________________________________|____________|
Epididymis | | 47 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach | | 1 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | | 3 |
__________________________________________________________________________|____________|
Prostate | | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 75
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
500 MG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | | 46 |
__________________________________________________________________________|____________|
Testes | | 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Femoral, Hemangiosarcoma | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 49 |
Bronchial, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
Mesenteric, Lymphoma Malignant | | |
Histiocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 49 |
__________________________________________________________________________|____________|
Spleen | | 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Hemangioma | | 2 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Histiocytic | | 2 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach | | 1 |
__________________________________________________________________________|____________|
Thymus | | 24 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | |
__________________________________________________________________________|____________|
Skin | | 49 |
Subcutaneous Tissue, Fibroma | | 4 |
Subcutaneous Tissue, Fibrosarcoma | | 5 |
Subcutaneous Tissue, Hemangiosarcoma | | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 49 |
Diaphragm, Squamous Cell Carcinoma, | | |
Metastatic, Stomach | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 76
NTP Experiment-Test: 05038-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:48:12
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
500 MG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Alveolar/Bronchiolar Adenoma | | 8 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Alveolar/Bronchiolar Carcinoma | | 4 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach | | 1 |
__________________________________________________________________________|____________|
Nose | | 50 |
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 48 |
Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 2 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach | | 1 |
__________________________________________________________________________|____________|
Ureter | | 43 |
__________________________________________________________________________|____________|
Urethra | | 29 |
__________________________________________________________________________|____________|
Urinary Bladder | | 48 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 50 |
Lymphoma Malignant Histiocytic | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 77
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