TR 354 Mouse Pathology Tables
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
Facility: Battelle Columbus Laboratory
Chemical CAS #: 828-00-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 5| 5| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 9| 3| 3| 2| 3| 3| 8| 0| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9|
| 1| 6| 1| 1| 4| 1| 9| 4| 3| 1| 1| 9| 1| 1| 8| 1| 1| 1| 1| 2| 2| 2| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + A A + + + + + + + + + + + + + + + + A|
Cyst | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + M + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 3|
Infarct | 4 |
Inflammation, Chronic | 3 |
Leukocytosis | X|
Necrosis, Coagulative | 2 |
Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Necrosis, Coagulative | |
Acinus, Atrophy | 1 4 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + M|
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 |
Fibrosis | |
Inflammation, Chronic Active | |
Necrosis, Fibrinoid | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 5| 5| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 9| 3| 3| 2| 3| 3| 8| 0| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9|
| 1| 6| 1| 1| 4| 1| 9| 4| 3| 1| 1| 9| 1| 1| 8| 1| 1| 1| 1| 2| 2| 2| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Degeneration, Fatty | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + M + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 2 2 2|
Cyst | X X X X X X X X X |
Inflammation, Chronic Active | 4 4 4|
Mineralization | 2 2 |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Bacterium | |
Inflammation, Suppurative | 2 1|
Endometrium, Hyperplasia, Cystic, | |
Glandular | 3 2 3 2 2 3 1 3 2 2 2 4 1 3 3 1 3 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia | 4 4 4|
Femoral, Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Inflammation, | |
Suppurative | |
Mesenteric, Angiectasis | 2 |
Mesenteric, Cyst | |
Mesenteric, Hematopoietic Cell | |
Proliferation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 5| 5| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 9| 3| 3| 2| 3| 3| 8| 0| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9|
| 1| 6| 1| 1| 4| 1| 9| 4| 3| 1| 1| 9| 1| 1| 8| 1| 1| 1| 1| 2| 2| 2| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 3 2 2 2 2 2 3 3|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | M + + M + + + M + M + M + + M + + M + + + + M + +|
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + + M M + M + + M +|
Hyperplasia, Cystic | 2 2 2 2 2 1 3 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Joint, Tarsal, Metaplasia, Osseous | 2 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Leukocytosis | X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + + M + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Glomerulosclerosis | |
Infarct, Chronic | |
Inflammation, Chronic Active | 2|
Metaplasia, Osseous | |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 5| 5| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 9| 3| 3| 2| 3| 3| 8| 0| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9|
| 1| 6| 1| 1| 4| 1| 9| 4| 3| 1| 1| 9| 1| 1| 8| 1| 1| 1| 1| 2| 2| 2| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy, Chronic | 1|
__________________________________________________________________________|
Ureter | + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3| 9| 3| 3| 2| 3| 3| 6|
| 2| 2| 2| 2| 2| 2| 2| 3| 9| 3| 3| 3| 3| 3| 3| 4| 3| 3| 6| 3| 3| 2| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + M A + + A|
Cyst | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + A + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + + + A|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + A + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + + A + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + M + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 1 3 2 2 2 2 |
Infarct | |
Inflammation, Chronic | 2 2 |
Leukocytosis | X |
Necrosis, Coagulative | 4 |
Pigmentation, Hemosiderin | 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + M|
Inflammation, Suppurative | 2 |
Necrosis, Coagulative | 3 |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + M + +|
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A|
Cyst | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | |
Fibrosis | 2 |
Inflammation, Chronic Active | 2 |
Necrosis, Fibrinoid | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3| 9| 3| 3| 2| 3| 3| 6|
| 2| 2| 2| 2| 2| 2| 2| 3| 9| 3| 3| 3| 3| 3| 3| 4| 3| 3| 6| 3| 3| 2| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Degeneration, Fatty | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + M + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 3 2 4 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + M + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Cyst | X X X X X X X X X |
Inflammation, Chronic Active | 3 4 |
Mineralization | 2 |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Bacterium | X |
Inflammation, Suppurative | 1 2 4 2 |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 3 2 2 3 2 3 3 2 2 2 2 2 2 2 3 3 2 2 1 2 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia | 4 |
Femoral, Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Inflammation, | |
Suppurative | 2 |
Mesenteric, Angiectasis | |
Mesenteric, Cyst | X |
Mesenteric, Hematopoietic Cell | |
Proliferation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3| 9| 3| 3| 2| 3| 3| 6|
| 2| 2| 2| 2| 2| 2| 2| 3| 9| 3| 3| 3| 3| 3| 3| 4| 3| 3| 6| 3| 3| 2| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation, Hemosiderin | 2 1 1 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 2 3 2 2 2 3 2 3 3 3 4 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + M + + + + M M M + M M M M + + + M M + M|
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia, Cystic | 2 4 2 1 1 4 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Joint, Tarsal, Metaplasia, Osseous | 2 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Leukocytosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Glomerulosclerosis | 4 |
Infarct, Chronic | 2 2 |
Inflammation, Chronic Active | 2 |
Metaplasia, Osseous | 2 |
Mineralization | 1|
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3| 9| 3| 3| 2| 3| 3| 6|
| 2| 2| 2| 2| 2| 2| 2| 3| 9| 3| 3| 3| 3| 3| 3| 4| 3| 3| 6| 3| 3| 2| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy, Chronic | 1 1 1 |
__________________________________________________________________________|
Ureter | + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Gallbladder | | 44 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Intestine Large | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 48 |
__________________________________________________________________________|____________|
Intestine Small | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 48 |
__________________________________________________________________________|____________|
Liver | | 50 |
Hematopoietic Cell Proliferation | | 11 2.0|
Infarct | | 1 4.0|
Inflammation, Chronic | | 3 2.3|
Leukocytosis | | 2 |
Necrosis, Coagulative | | 2 3.0|
Pigmentation, Hemosiderin | | 3 2.3|
__________________________________________________________________________|____________|
Mesentery | | 41 |
Inflammation, Chronic Active | | 4 2.5|
__________________________________________________________________________|____________|
Pancreas | | 49 |
Inflammation, Suppurative | | 1 2.0|
Necrosis, Coagulative | | 1 3.0|
Acinus, Atrophy | | 3 2.7|
__________________________________________________________________________|____________|
Salivary Glands | | 48 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 49 |
Hyperplasia, Focal | | 3 2.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 49 |
Cyst | | 1 1.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 50 |
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 45 |
__________________________________________________________________________|____________|
Heart | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy, Chronic | | 1 2.0|
Fibrosis | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Necrosis, Fibrinoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Accessory Adrenal Cortical Nodule | | 1 |
Degeneration, Fatty | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 49 |
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 49 |
__________________________________________________________________________|____________|
Pituitary Gland | | 47 |
Pars Distalis, Cyst | | 2 |
Pars Distalis, Hyperplasia | | 14 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Follicular Cell, Hyperplasia | | 9 2.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 49 |
Atrophy | | 6 2.2|
Cyst | | 18 |
Inflammation, Chronic Active | | 5 3.8|
Mineralization | | 3 2.0|
__________________________________________________________________________|____________|
Oviduct | | 46 |
__________________________________________________________________________|____________|
Uterus | | 50 |
Angiectasis | | 1 2.0|
Bacterium | | 1 |
Inflammation, Suppurative | | 6 2.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | | 40 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Femoral, Hyperplasia | | 4 4.0|
Femoral, Myelofibrosis | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Mediastinal, Inflammation, | | |
Suppurative | | 1 2.0|
Mesenteric, Angiectasis | | 1 2.0|
Mesenteric, Cyst | | 1 |
Mesenteric, Hematopoietic Cell | | |
Proliferation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 48 |
Pigmentation, Hemosiderin | | 6 1.2|
__________________________________________________________________________|____________|
Spleen | | 50 |
Hematopoietic Cell Proliferation | | 26 2.4|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | | 31 |
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 44 |
Hyperplasia, Cystic | | 17 2.1|
__________________________________________________________________________|____________|
Skin | | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Joint, Tarsal, Metaplasia, Osseous | | 2 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Compression | | 1 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Inflammation, Chronic Active | | 1 3.0|
Leukocytosis | | 1 |
__________________________________________________________________________|____________|
Nose | | 50 |
__________________________________________________________________________|____________|
Trachea | | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 48 |
Hyperplasia | | 3 1.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Cyst | | 1 |
Glomerulosclerosis | | 1 4.0|
Infarct, Chronic | | 2 2.0|
Inflammation, Chronic Active | | 2 2.0|
Metaplasia, Osseous | | 1 2.0|
Mineralization | | 1 1.0|
Nephropathy, Chronic | | 4 1.0|
__________________________________________________________________________|____________|
Ureter | | 16 |
__________________________________________________________________________|____________|
Urinary Bladder | | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 6| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 0| 5| 3| 2| 8| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 3| 3|
| 1| 9| 1| 1| 1| 9| 1| 1| 2| 4| 1| 3| 0| 1| 1| 1| 2| 1| 2| 9| 2| 0| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 MG/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + |
__________________________________________________________________________|
Gallbladder | A + + A A M A |
__________________________________________________________________________|
Intestine Large | + + + + + + A |
__________________________________________________________________________|
Intestine Large, Cecum | A + + + M + A |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A A |
__________________________________________________________________________|
Intestine Small | + + + + + + + A |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A A A A |
Amyloid Deposition | |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + A |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A |
__________________________________________________________________________|
Liver | + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + |
Cyst | X |
Acinus, Atrophy | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 3 4 |
Hyperkeratosis | 2 3 3 |
Hyperplasia, Focal | 2 3 2 2|
Hyperplasia, Lymphoid | 4 |
Inflammation, Chronic Active | 2 3 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + A |
__________________________________________________________________________|
Tooth | + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + |
Necrosis, Coagulative | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M M |
Pars Distalis, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 6| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 0| 5| 3| 2| 8| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 3| 3|
| 1| 9| 1| 1| 1| 9| 1| 1| 2| 4| 1| 3| 0| 1| 1| 1| 2| 1| 2| 9| 2| 0| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 MG/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + M + + + + + + + + + |
Atrophy | 2 |
Cyst | X X X X X |
__________________________________________________________________________|
Oviduct | + + + + + + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Thrombosis | X |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 4 2 3 3 3 2 2 3 2 3 2 3 2 1 3 3 3 2 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Mesenteric, Angiectasis | |
Mesenteric, Hematopoietic Cell | |
Proliferation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 3 |
__________________________________________________________________________|
Thymus | + + M + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M M + + |
__________________________________________________________________________|
Skin | + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + |
Edema | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 6| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 0| 5| 3| 2| 8| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 3| 3|
| 1| 9| 1| 1| 1| 9| 1| 1| 2| 4| 1| 3| 0| 1| 1| 1| 2| 1| 2| 9| 2| 0| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 MG/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + M + M + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + |
Glomerulosclerosis | |
__________________________________________________________________________|
Ureter | + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + A |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 3| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 8| 3| 3| 3| 3| 3| 0| 1| 3|
| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 7| 1| 5| 3| 9| 3| 3| 3| 6| 3| 1| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 MG/ | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + |
__________________________________________________________________________|
Gallbladder | A + + + A A + |
__________________________________________________________________________|
Intestine Large | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + M + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + A + + |
Amyloid Deposition | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + M + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + M + + |
__________________________________________________________________________|
Liver | + + + + + + + + + |
Hematopoietic Cell Proliferation | |
Necrosis, Coagulative | 2 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Pancreas | + + + + A + + |
Cyst | |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + M + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + A + + + +|
Acanthosis | 2 |
Hyperkeratosis | 2 |
Hyperplasia, Focal | 2 3 2 2 2 1 2 2 1 1|
Hyperplasia, Lymphoid | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + |
__________________________________________________________________________|
Tooth | + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + |
Necrosis, Coagulative | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + |
__________________________________________________________________________|
Parathyroid Gland | + M + + M M + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + |
Pars Distalis, Hyperplasia | 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 3| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 8| 3| 3| 3| 3| 3| 0| 1| 3|
| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 7| 1| 5| 3| 9| 3| 3| 3| 6| 3| 1| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 MG/ | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + |
Atrophy | 2 |
Cyst | X X X X |
__________________________________________________________________________|
Oviduct | + + + + + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 2 |
Thrombosis | |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 2 2 2 3 3 4 3 2 3 3 2 2 2 2 3 3 3 1 2 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + M + M |
Mesenteric, Angiectasis | 3 1 |
Mesenteric, Hematopoietic Cell | |
Proliferation | 2 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + M |
__________________________________________________________________________|
Spleen | + + + + + + + + + + |
Hematopoietic Cell Proliferation | 3 3 4 4 |
__________________________________________________________________________|
Thymus | + + M + M M M |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + M |
__________________________________________________________________________|
Skin | + + + + M + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + |
Edema | 3 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 3| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 8| 3| 3| 3| 3| 3| 0| 1| 3|
| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 7| 1| 5| 3| 9| 3| 3| 3| 6| 3| 1| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 MG/ | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + M |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + |
Glomerulosclerosis | 4 |
__________________________________________________________________________|
Ureter | + + |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
250 MG/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 14 |
__________________________________________________________________________|____________|
Gallbladder | | 6 |
__________________________________________________________________________|____________|
Intestine Large | | 13 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 12 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 11 |
__________________________________________________________________________|____________|
Intestine Small | | 14 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 8 |
Amyloid Deposition | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 13 |
__________________________________________________________________________|____________|
Liver | | 19 |
Hematopoietic Cell Proliferation | | 1 2.0|
Necrosis, Coagulative | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 11 |
Inflammation, Chronic Active | | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | | 15 |
Cyst | | 1 |
Acinus, Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | | 13 |
__________________________________________________________________________|____________|
Stomach | | 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 48 |
Acanthosis | | 5 2.6|
Hyperkeratosis | | 4 2.5|
Hyperplasia, Focal | | 14 1.9|
Hyperplasia, Lymphoid | | 1 4.0|
Inflammation, Chronic Active | | 4 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | | 12 |
__________________________________________________________________________|____________|
Tooth | | 14 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 11 |
__________________________________________________________________________|____________|
Heart | | 14 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 14 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 14 |
Necrosis, Coagulative | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 14 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
250 MG/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 13 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 11 |
__________________________________________________________________________|____________|
Pituitary Gland | | 19 |
Pars Distalis, Hyperplasia | | 3 2.7|
__________________________________________________________________________|____________|
Thyroid Gland | | 14 |
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 21 |
Atrophy | | 2 2.0|
Cyst | | 9 |
__________________________________________________________________________|____________|
Oviduct | | 13 |
__________________________________________________________________________|____________|
Uterus | | 43 |
Inflammation, Suppurative | | 4 2.0|
Thrombosis | | 1 |
Endometrium, Hyperplasia, Cystic, | | |
Glandular | | 40 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 14 |
__________________________________________________________________________|____________|
Lymph Node | | 16 |
Mesenteric, Angiectasis | | 2 2.0|
Mesenteric, Hematopoietic Cell | | |
Proliferation | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 13 |
__________________________________________________________________________|____________|
Spleen | | 23 |
Hematopoietic Cell Proliferation | | 6 3.5|
__________________________________________________________________________|____________|
Thymus | | 9 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 10 |
__________________________________________________________________________|____________|
Skin | | 14 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 14 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
250 MG/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 14 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 14 |
Edema | | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | | 14 |
__________________________________________________________________________|____________|
Trachea | | 14 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 11 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 14 |
Glomerulosclerosis | | 1 4.0|
__________________________________________________________________________|____________|
Ureter | | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 2| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 3| 8| 9| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 8| 1| 1| 1| 1| 1| 1| 2| 6| 1| 1| 1| 1| 3| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
500 MG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + + + M A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + M + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + M + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Small | + A + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + A + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + A + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X |
Hematopoietic Cell Proliferation | 1 1 2 2 1 |
Hyperplasia, Lymphoid | 2 |
Inflammation, Necrotizing | |
Leukocytosis | |
Necrosis, Coagulative | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Necrosis, Coagulative | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + A + + + + + + + + + + + + + + +|
Acanthosis | 2 1 2 2 2 2 2 2 2 3 |
Hyperkeratosis | 2 1 2 2 2 1 2 2 2 1 1 2 3 |
Hyperplasia, Focal | 1 2 1 2 2 2 1 3 3 2|
Hyperplasia, Lymphoid | 3 |
Inflammation, Chronic Active | 2 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +|
Cyst | 1 1 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 2| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 3| 8| 9| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 8| 1| 1| 1| 1| 1| 1| 2| 6| 1| 1| 1| 1| 3| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
500 MG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X|
Degeneration, Fatty | 2 |
Hematopoietic Cell Proliferation | |
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M M + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + M + + + + + + + A + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 2 |
Cyst | X X X X X X X X X X |
Inflammation, Chronic Active | |
Mineralization | 1 |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation, Suppurative | 2 |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 4 2 2 3 3 1 3 2 2 2 1 2 1 3 2 2 2 2 2 1 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia | |
Femoral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Pigmentation, | |
Hemosiderin | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 2| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 3| 8| 9| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 8| 1| 1| 1| 1| 1| 1| 2| 6| 1| 1| 1| 1| 3| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
500 MG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation, Hemosiderin | 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 2 3 2 2 3 3 2 2|
Hyperplasia, Lymphoid | 2 3 3 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Thymus | + + M + + + + M + M M M + + M + M + + + + + M + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M + + + + + M M + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 2 2 1 2 3 3 1 2 1 1 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic Active | 2 2 |
Leukocytosis | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 2| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 3| 8| 9| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 8| 1| 1| 1| 1| 1| 1| 2| 6| 1| 1| 1| 1| 3| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
500 MG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Glomerulosclerosis | 4 |
Hyperplasia, Lymphoid | 3 |
Nephropathy, Chronic | 1 1 1 |
__________________________________________________________________________|
Ureter | + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 7| 7| 7| 7| 5| 7| 6| 5| 6| 6| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 3| 5| 7| 3| 3| 3| 3| 3| 8| 3| 5| 0| 4| 5| 8| 3| 3| 3| 3| 3| 8| 7| 3| 0|
| 2| 2| 5| 4| 2| 3| 3| 3| 3| 4| 3| 3| 9| 6| 4| 8| 3| 3| 3| 4| 3| 0| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
500 MG/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + A + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + + + + M + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + M + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | M + + + + + + + + + + + + + A + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + M M + + + + + + + + + + + + + + + + + + + + + A|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | |
Hematopoietic Cell Proliferation | 1 3 1 1 3 3|
Hyperplasia, Lymphoid | |
Inflammation, Necrotizing | 2 2|
Leukocytosis | X X|
Necrosis, Coagulative | 3 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 4|
Necrosis, Coagulative | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + M + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 1 2 2 2 2 3 3 2 2 2 2 2 |
Hyperkeratosis | 2 1 1 2 2 2 2 2 1 3 2 2 2 2 |
Hyperplasia, Focal | 2 4 2 2 2 2 1 2 1 3 2 4 |
Hyperplasia, Lymphoid | |
Inflammation, Chronic Active | 2 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + M + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 7| 7| 7| 7| 5| 7| 6| 5| 6| 6| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 3| 5| 7| 3| 3| 3| 3| 3| 8| 3| 5| 0| 4| 5| 8| 3| 3| 3| 3| 3| 8| 7| 3| 0|
| 2| 2| 5| 4| 2| 3| 3| 3| 3| 4| 3| 3| 9| 6| 4| 8| 3| 3| 3| 4| 3| 0| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
500 MG/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Degeneration, Fatty | |
Hematopoietic Cell Proliferation | 2 |
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + I + + M + +|
Pars Distalis, Hyperplasia | 2 2 1 2 2 2 2 2 2 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + +|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | X X X X X X X X X X X |
Inflammation, Chronic Active | 4 |
Mineralization | |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Suppurative | 2 4 1 2 |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 3 3 2 1 3 2 1 2 3 1 1 2 2 2 2 2 1 3 2 1 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia | 4 4 4|
Femoral, Myelofibrosis | 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Pigmentation, | |
Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 7| 7| 7| 7| 5| 7| 6| 5| 6| 6| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 3| 5| 7| 3| 3| 3| 3| 3| 8| 3| 5| 0| 4| 5| 8| 3| 3| 3| 3| 3| 8| 7| 3| 0|
| 2| 2| 5| 4| 2| 3| 3| 3| 3| 4| 3| 3| 9| 6| 4| 8| 3| 3| 3| 4| 3| 0| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
500 MG/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation, Hemosiderin | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 4 2 2 2 2 4 3 2 2 2 4 4|
Hyperplasia, Lymphoid | |
Necrosis, Coagulative | 2 |
__________________________________________________________________________|
Thymus | + M + + + M + M + M M + M + M + + M + M + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + M + M + + + + M + + M M + + + + + +|
Hyperplasia, Cystic | 2 2 1 2 2 2 2 2 4 1 1 1 2 1 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + |
Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Hydrocephalus | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Infiltration Cellular, Lymphocyte | 2 2 |
Inflammation, Chronic Active | |
Leukocytosis | X X X|
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 2 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 7| 7| 7| 7| 5| 7| 6| 5| 6| 6| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 3| 5| 7| 3| 3| 3| 3| 3| 8| 3| 5| 0| 4| 5| 8| 3| 3| 3| 3| 3| 8| 7| 3| 0|
| 2| 2| 5| 4| 2| 3| 3| 3| 3| 4| 3| 3| 9| 6| 4| 8| 3| 3| 3| 4| 3| 0| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
500 MG/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Glomerulosclerosis | |
Hyperplasia, Lymphoid | |
Nephropathy, Chronic | 1 3 2 |
__________________________________________________________________________|
Ureter | + + + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
500 MG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Gallbladder | | 45 |
__________________________________________________________________________|____________|
Intestine Large | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 48 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 44 |
__________________________________________________________________________|____________|
Intestine Small | | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 45 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Liver | | 50 |
Angiectasis | | 1 2.0|
Basophilic Focus | | 1 |
Hematopoietic Cell Proliferation | | 11 1.7|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Necrotizing | | 2 2.0|
Leukocytosis | | 2 |
Necrosis, Coagulative | | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | | 49 |
Inflammation, Chronic Active | | 2 3.0|
Necrosis, Coagulative | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | | 49 |
Hyperplasia, Lymphoid | | 1 3.0|
Acinus, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | | 49 |
__________________________________________________________________________|____________|
Stomach | | 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 48 |
Acanthosis | | 23 2.0|
Hyperkeratosis | | 27 1.8|
Hyperplasia, Focal | | 22 2.1|
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Chronic Active | | 6 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 48 |
Cyst | | 4 1.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 50 |
Dysplasia | | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
500 MG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 45 |
__________________________________________________________________________|____________|
Heart | | 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Cyst | | 2 |
Degeneration, Fatty | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hypertrophy | | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 47 |
__________________________________________________________________________|____________|
Pituitary Gland | | 45 |
Pars Distalis, Hyperplasia | | 18 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 47 |
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 50 |
Atrophy | | 3 2.3|
Cyst | | 21 |
Inflammation, Chronic Active | | 1 4.0|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Oviduct | | 47 |
__________________________________________________________________________|____________|
Uterus | | 50 |
Hemorrhage | | 1 3.0|
Inflammation, Suppurative | | 5 2.2|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | | 45 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
500 MG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Femoral, Hyperplasia | | 3 4.0|
Femoral, Myelofibrosis | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 49 |
Pigmentation, Hemosiderin | | 4 1.0|
__________________________________________________________________________|____________|
Spleen | | 50 |
Hematopoietic Cell Proliferation | | 23 2.6|
Hyperplasia, Lymphoid | | 3 2.7|
Necrosis, Coagulative | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | | 31 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 40 |
Hyperplasia, Cystic | | 28 1.8|
__________________________________________________________________________|____________|
Skin | | 49 |
Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 50 |
Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Compression | | 1 |
Hydrocephalus | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Hyperplasia, Lymphoid | | 2 2.5|
Infiltration Cellular, Lymphocyte | | 2 2.0|
Inflammation, Chronic Active | | 2 2.0|
Leukocytosis | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
500 MG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
Lens, Cataract | | 1 2.0|
Retina, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 50 |
Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Glomerulosclerosis | | 1 4.0|
Hyperplasia, Lymphoid | | 1 3.0|
Nephropathy, Chronic | | 6 1.5|
__________________________________________________________________________|____________|
Ureter | | 16 |
__________________________________________________________________________|____________|
Urinary Bladder | | 49 |
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 1|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 8| 3| 4| 0| 3| 3| 3| 3| 3| 2| 1| 6| 3| 1| 3| 3| 3| 3| 0|
| 1| 1| 1| 1| 1| 1| 9| 1| 9| 9| 1| 1| 1| 1| 2| 9| 6| 4| 2| 9| 2| 2| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Gallbladder | M + + + + + M + + A + + + + + + A + + + + + + + M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + M + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + M + + + + + + + M|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + M + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | X |
Necrosis, Coagulative | 2 3 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + A + + + + + + + M|
Acinus, Atrophy | 1 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + M|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + A + + + + + + + M|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + A + + + + + + + M|
Acanthosis, Focal | 1 1 |
Hyperkeratosis, Focal | 2 |
Hyperplasia, Focal | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + + + + + M|
Cyst | X |
Diverticulum | 2 |
Dysplasia | 2 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 2 2 2 |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + M|
Cardiomyopathy, Chronic | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 1|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 8| 3| 4| 0| 3| 3| 3| 3| 3| 2| 1| 6| 3| 1| 3| 3| 3| 3| 0|
| 1| 1| 1| 1| 1| 1| 9| 1| 9| 9| 1| 1| 1| 1| 2| 9| 6| 4| 2| 9| 2| 2| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + + + + + + + M|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + M + + + + + + + M|
Cyst | X X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + M|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ductus Deferens | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + |
__________________________________________________________________________|
Preputial Gland | + + + + |
Duct, Dilatation | 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + M + + + + + + + + + M M + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | 1 |
Mineralization | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric, Angiectasis | 3 3 2 2 2 2 |
Mesenteric, Hematopoietic Cell | |
Proliferation | 3 3 2 2 2 3 |
Mesenteric, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hematopoietic Cell Proliferation | 3 2 3 3 2 3 3 4 3 3 3 2 3 3 |
__________________________________________________________________________|
Thymus | + + + M M + + M M M M + + + M + + + + M + M + M M|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 1|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 8| 3| 4| 0| 3| 3| 3| 3| 3| 2| 1| 6| 3| 1| 3| 3| 3| 3| 0|
| 1| 1| 1| 1| 1| 1| 9| 1| 9| 9| 1| 1| 1| 1| 2| 9| 6| 4| 2| 9| 2| 2| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M + M M M + M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | |
Fibrosis | |
Inflammation, Chronic Active | 2 3 2 4 2|
Parasite External | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Joint, Tarsal, Metaplasia, Osseous | 4 2 3 4 4 4 4 4 4 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + M|
Edema, Acute | 4 |
Hemorrhage, Acute | 4 |
Inflammation, Chronic Active | 1 |
Alveolar Epithelium, Hyperplasia | 2 1 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + M|
Inflammation, Suppurative | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + I + + + + + + + + + + + + + + M|
Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Glomerulosclerosis | 4 |
Hydronephrosis | 2 |
Infarct | |
Necrosis, Coagulative | |
Nephropathy, Chronic | 2 2 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Ureter | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Urethra | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 1|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 8| 3| 4| 0| 3| 3| 3| 3| 3| 2| 1| 6| 3| 1| 3| 3| 3| 3| 0|
| 1| 1| 1| 1| 1| 1| 9| 1| 9| 9| 1| 1| 1| 1| 2| 9| 6| 4| 2| 9| 2| 2| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + M + + + + + + + + + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 5| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 0| 3| 2| 3| 3| 3| 6| 4| 3| 3| 2| 3| 3| 3| 4| 3| 3| 8| 3| 3|
| 2| 2| 2| 5| 2| 0| 2| 4| 3| 3| 3| 6| 9| 3| 3| 0| 3| 3| 3| 2| 3| 3| 4| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + + + + + A M M + M + + + A + M A A +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + M + + + + + + + + + + + A + + + + + + A + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + M + + + + + + + + + + + A + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + M + + + + + A + + + + + + M + +|
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + M + + + + + + + + + A + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + M + + + + + + + + + A + + + + + + A + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Hepatodiaphragmatic Nodule | |
Necrosis, Coagulative | 3 3 3 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Acinus, Hyperplasia | 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | |
Hyperkeratosis, Focal | |
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Diverticulum | |
Dysplasia | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 2 3 2 2 2|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 5| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 0| 3| 2| 3| 3| 3| 6| 4| 3| 3| 2| 3| 3| 3| 4| 3| 3| 8| 3| 3|
| 2| 2| 2| 5| 2| 0| 2| 4| 3| 3| 3| 6| 9| 3| 3| 0| 3| 3| 3| 2| 3| 3| 4| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + M + M + + + + + + M M + + + + M + +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + + M + +|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 1 1 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Ductus Deferens | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + |
Duct, Dilatation | 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + M + + + + M + + M + + + M + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric, Angiectasis | 2 2 3 2 |
Mesenteric, Hematopoietic Cell | |
Proliferation | 2 2 2 2 3 2 |
Mesenteric, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 4 2 2 4 2 3 4 |
__________________________________________________________________________|
Thymus | + + + M + M + + + M + M M M M M + M + M + + M M +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 5| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 0| 3| 2| 3| 3| 3| 6| 4| 3| 3| 2| 3| 3| 3| 4| 3| 3| 8| 3| 3|
| 2| 2| 2| 5| 2| 0| 2| 4| 3| 3| 3| 6| 9| 3| 3| 0| 3| 3| 3| 2| 3| 3| 4| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M + M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | X |
Fibrosis | 2 2 4 |
Inflammation, Chronic Active | 3 2 2 2 |
Parasite External | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Joint, Tarsal, Metaplasia, Osseous | 2 3 4 3 3 4 4 4 3 2 3 4 2 4 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema, Acute | |
Hemorrhage, Acute | |
Inflammation, Chronic Active | 3 |
Alveolar Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Glomerulosclerosis | |
Hydronephrosis | |
Infarct | 2 |
Necrosis, Coagulative | 2 |
Nephropathy, Chronic | 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Ureter | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urethra | + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 5| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 0| 3| 2| 3| 3| 3| 6| 4| 3| 3| 2| 3| 3| 3| 4| 3| 3| 8| 3| 3|
| 2| 2| 2| 5| 2| 0| 2| 4| 3| 3| 3| 6| 9| 3| 3| 0| 3| 3| 3| 2| 3| 3| 4| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + A + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 49 |
__________________________________________________________________________|____________|
Gallbladder | | 36 |
__________________________________________________________________________|____________|
Intestine Large | | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 46 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | | 47 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 45 |
__________________________________________________________________________|____________|
Intestine Small | | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 44 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 47 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Liver | | 49 |
Hematopoietic Cell Proliferation | | 2 2.5|
Hepatodiaphragmatic Nodule | | 1 |
Necrosis, Coagulative | | 5 2.8|
__________________________________________________________________________|____________|
Mesentery | | 41 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | | 48 |
Acinus, Atrophy | | 1 1.0|
Acinus, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | | 49 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | | 47 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 47 |
Acanthosis, Focal | | 2 1.0|
Hyperkeratosis, Focal | | 1 2.0|
Hyperplasia, Focal | | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 47 |
Cyst | | 1 |
Diverticulum | | 1 2.0|
Dysplasia | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 50 |
Dysplasia | | 8 2.1|
Inflammation, Chronic Active | | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 43 |
__________________________________________________________________________|____________|
Heart | | 49 |
Cardiomyopathy, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Hyperplasia | | 5 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 41 |
Cyst | | 3 |
__________________________________________________________________________|____________|
Pituitary Gland | | 46 |
Pars Distalis, Cyst | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | | 49 |
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | | 7 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 45 |
__________________________________________________________________________|____________|
Ductus Deferens | | 47 |
__________________________________________________________________________|____________|
Epididymis | | 50 |
__________________________________________________________________________|____________|
Penis | | 2 |
__________________________________________________________________________|____________|
Preputial Gland | | 6 |
Duct, Dilatation | | 4 2.5|
__________________________________________________________________________|____________|
Prostate | | 48 |
__________________________________________________________________________|____________|
Seminal Vesicle | | 43 |
__________________________________________________________________________|____________|
Testes | | 50 |
Inflammation, Necrotizing | | 1 1.0|
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Mesenteric, Angiectasis | | 10 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mesenteric, Hematopoietic Cell | | |
Proliferation | | 12 2.3|
Mesenteric, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 48 |
__________________________________________________________________________|____________|
Spleen | | 49 |
Hematopoietic Cell Proliferation | | 23 2.9|
__________________________________________________________________________|____________|
Thymus | | 27 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 3 |
__________________________________________________________________________|____________|
Skin | | 50 |
Alopecia | | 1 |
Fibrosis | | 3 2.7|
Inflammation, Chronic Active | | 9 2.4|
Parasite External | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Joint, Tarsal, Metaplasia, Osseous | | 23 3.4|
__________________________________________________________________________|____________|
Skeletal Muscle | | 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 49 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 49 |
Edema, Acute | | 1 4.0|
Hemorrhage, Acute | | 1 4.0|
Inflammation, Chronic Active | | 2 2.0|
Alveolar Epithelium, Hyperplasia | | 6 1.8|
__________________________________________________________________________|____________|
Nose | | 49 |
Inflammation, Suppurative | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 1.5|
__________________________________________________________________________|____________|
Trachea | | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 48 |
Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Cyst | | 1 |
Glomerulosclerosis | | 1 4.0|
Hydronephrosis | | 1 2.0|
Infarct | | 1 2.0|
Necrosis, Coagulative | | 1 2.0|
Nephropathy, Chronic | | 27 1.1|
__________________________________________________________________________|____________|
Ureter | | 41 |
__________________________________________________________________________|____________|
Urethra | | 23 |
__________________________________________________________________________|____________|
Urinary Bladder | | 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| 6| 7| 7| 7| 2|
DAY ON TEST | 3| 3| 7| 3| 3| 0| 8| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2| 1| 3| 3| 3| 8|
| 1| 1| 8| 1| 1| 9| 2| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 5| 3| 2| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 MG/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + + + + + A A A|
__________________________________________________________________________|
Intestine Large | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + M + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A|
__________________________________________________________________________|
Intestine Small | A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + +|
Inflammation, Necrotizing | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + +|
Cyst | |
Infarct | 4 |
Inflammation, Chronic | |
Inflammation, Necrotizing | 4 |
Necrosis, Coagulative | 3 4 |
Thrombosis | X |
__________________________________________________________________________|
Mesentery | + + + + + + + +|
__________________________________________________________________________|
Pancreas | + + + + + + + +|
Inflammation, Chronic Active | 4 |
Acinus, Atrophy | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 2 |
Hyperkeratosis | |
Hyperplasia, Focal | 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + +|
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + +|
Inflammation, Chronic Active | |
Valve, Bacterium | X |
Valve, Inflammation, Chronic Active | 4 |
Valve, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| 6| 7| 7| 7| 2|
DAY ON TEST | 3| 3| 7| 3| 3| 0| 8| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2| 1| 3| 3| 3| 8|
| 1| 1| 8| 1| 1| 9| 2| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 5| 3| 2| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 MG/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + M|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + +|
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + +|
__________________________________________________________________________|
Ductus Deferens | + + + + + + +|
__________________________________________________________________________|
Epididymis | + + + + + + + +|
__________________________________________________________________________|
Penis | + + + +|
Hemorrhage | 4 |
__________________________________________________________________________|
Preputial Gland | + + + + +|
Inflammation, Chronic Active | 4 4 |
Duct, Dilatation | 2|
__________________________________________________________________________|
Prostate | + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Testes | + + + + + + + +|
Germinal Epithelium, Degeneration | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + +|
Femoral, Hyperplasia | 4|
__________________________________________________________________________|
Lymph Node | + M + + + + + + +|
Axillary, Hyperplasia, Plasma Cell | |
Inguinal, Hyperplasia, Plasma Cell | |
Lumbar, Hyperplasia, Plasma Cell | |
Mesenteric, Angiectasis | 4 |
Mesenteric, Cyst | |
Mesenteric, Hematopoietic Cell | |
Proliferation | |
Mesenteric, Thrombosis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + +|
Inflammation, Chronic Active | 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| 6| 7| 7| 7| 2|
DAY ON TEST | 3| 3| 7| 3| 3| 0| 8| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2| 1| 3| 3| 3| 8|
| 1| 1| 8| 1| 1| 9| 2| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 5| 3| 2| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 MG/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + M + M M + M|
Cyst | |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Chronic Active | 2 3|
Metaplasia, Osseous | |
Necrosis, Coagulative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + +|
Joint, Femur, Tibia, Metaplasia, | |
Osseous | |
Joint, Tarsal, Metaplasia, Osseous | 4 3 4 4 4 4 4 4 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + +|
Compression | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + +|
Leukocytosis | |
__________________________________________________________________________|
Nose | + + + + + + + +|
Inflammation, Suppurative | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + M + +|
Hyperplasia | 4 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + +|
Hydronephrosis | 2 2 |
Infarct | 2 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| 6| 7| 7| 7| 2|
DAY ON TEST | 3| 3| 7| 3| 3| 0| 8| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2| 1| 3| 3| 3| 8|
| 1| 1| 8| 1| 1| 9| 2| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 5| 3| 2| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 MG/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Suppurative | |
Mineralization | 1 |
Nephropathy, Chronic | 1 |
Artery, Necrosis, Fibrinoid | |
__________________________________________________________________________|
Ureter | + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Urethra | + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + +|
Dilatation | 4 4 4 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 6| 4| 1| 0| 6| 6| 5| 5| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 0| 7| 6| 5| 7| 4|
DAY ON TEST | 3| 0| 4| 0| 3| 6| 8| 4| 5| 3| 3| 3| 3| 3| 3| 3| 8| 6| 3| 0| 3| 7| 5| 3| 5|
| 2| 5| 6| 2| 0| 7| 8| 9| 5| 3| 3| 3| 3| 3| 7| 3| 9| 2| 3| 3| 3| 5| 1| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
250 MG/ | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + A + A + + |
__________________________________________________________________________|
Intestine Large | + A + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + A + M + + + + A + A + + |
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + A + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + A + M + + + + A + + + + |
__________________________________________________________________________|
Intestine Small | + A + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + A + + + + |
Inflammation, Necrotizing | |
__________________________________________________________________________|
Intestine Small, Ileum | + A + M + + + + A + A + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + M + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + |
Cyst | X |
Infarct | |
Inflammation, Chronic | 2 |
Inflammation, Necrotizing | 2 |
Necrosis, Coagulative | 3 2 |
Thrombosis | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + A + + + + |
Inflammation, Chronic Active | |
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + + + + |
Acanthosis | 2 |
Hyperkeratosis | 2 |
Hyperplasia, Focal | 4 4 4 4 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A + + + + |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + |
Dysplasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + |
Inflammation, Chronic Active | 1 |
Valve, Bacterium | |
Valve, Inflammation, Chronic Active | |
Valve, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 6| 4| 1| 0| 6| 6| 5| 5| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 0| 7| 6| 5| 7| 4|
DAY ON TEST | 3| 0| 4| 0| 3| 6| 8| 4| 5| 3| 3| 3| 3| 3| 3| 3| 8| 6| 3| 0| 3| 7| 5| 3| 5|
| 2| 5| 6| 2| 0| 7| 8| 9| 5| 3| 3| 3| 3| 3| 7| 3| 9| 2| 3| 3| 3| 5| 1| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
250 MG/ | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + A + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + M + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + |
__________________________________________________________________________|
Ductus Deferens | + + + + + + + + + + + + + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + |
__________________________________________________________________________|
Penis | |
Hemorrhage | |
__________________________________________________________________________|
Preputial Gland | + |
Inflammation, Chronic Active | |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + |
Germinal Epithelium, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + |
Femoral, Hyperplasia | 4 4 4 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + |
Axillary, Hyperplasia, Plasma Cell | 3 |
Inguinal, Hyperplasia, Plasma Cell | 3 |
Lumbar, Hyperplasia, Plasma Cell | 4 |
Mesenteric, Angiectasis | 2 3 3 3 2 |
Mesenteric, Cyst | X |
Mesenteric, Hematopoietic Cell | |
Proliferation | 3 2 2 2 3 |
Mesenteric, Thrombosis | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 3 4 3 2 3 3 4 4 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 6| 4| 1| 0| 6| 6| 5| 5| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 0| 7| 6| 5| 7| 4|
DAY ON TEST | 3| 0| 4| 0| 3| 6| 8| 4| 5| 3| 3| 3| 3| 3| 3| 3| 8| 6| 3| 0| 3| 7| 5| 3| 5|
| 2| 5| 6| 2| 0| 7| 8| 9| 5| 3| 3| 3| 3| 3| 7| 3| 9| 2| 3| 3| 3| 5| 1| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
250 MG/ | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | M + + + M + M + + M + M + |
Cyst | X X |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + |
Hyperkeratosis | 2 |
Inflammation, Chronic Active | 3 3 4 4 |
Metaplasia, Osseous | 3 |
Necrosis, Coagulative | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + |
Joint, Femur, Tibia, Metaplasia, | |
Osseous | 4 |
Joint, Tarsal, Metaplasia, Osseous | 4 4 4 4 4 4 4 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + |
Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + |
Leukocytosis | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + |
Inflammation, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + I + + |
Hyperplasia | |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + |
Hydronephrosis | 3 2 4 |
Infarct | |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 6| 4| 1| 0| 6| 6| 5| 5| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 0| 7| 6| 5| 7| 4|
DAY ON TEST | 3| 0| 4| 0| 3| 6| 8| 4| 5| 3| 3| 3| 3| 3| 3| 3| 8| 6| 3| 0| 3| 7| 5| 3| 5|
| 2| 5| 6| 2| 0| 7| 8| 9| 5| 3| 3| 3| 3| 3| 7| 3| 9| 2| 3| 3| 3| 5| 1| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
250 MG/ | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Suppurative | 2 |
Mineralization | 2 |
Nephropathy, Chronic | 2 2 1 |
Artery, Necrosis, Fibrinoid | 3 |
__________________________________________________________________________|
Ureter | + + + + + + + + + + + + |
Dilatation | 4 |
__________________________________________________________________________|
Urethra | + + + + + + + + + + |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + |
Dilatation | 3 4 |
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
250 MG/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 21 |
__________________________________________________________________________|____________|
Gallbladder | | 16 |
__________________________________________________________________________|____________|
Intestine Large | | 19 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 15 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 19 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 16 |
__________________________________________________________________________|____________|
Intestine Small | | 20 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 18 |
Inflammation, Necrotizing | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 16 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 19 |
__________________________________________________________________________|____________|
Liver | | 28 |
Cyst | | 1 |
Infarct | | 1 4.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Necrotizing | | 2 3.0|
Necrosis, Coagulative | | 4 3.0|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 19 |
__________________________________________________________________________|____________|
Pancreas | | 20 |
Inflammation, Chronic Active | | 1 4.0|
Acinus, Atrophy | | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | | 21 |
__________________________________________________________________________|____________|
Stomach | | 47 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 47 |
Acanthosis | | 4 1.5|
Hyperkeratosis | | 1 2.0|
Hyperplasia, Focal | | 7 3.9|
__________________________________________________________________________|____________|
Stomach, Glandular | | 20 |
__________________________________________________________________________|____________|
Tooth | | 20 |
Dysplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 21 |
__________________________________________________________________________|____________|
Heart | | 21 |
Inflammation, Chronic Active | | 1 1.0|
Valve, Bacterium | | 1 |
Valve, Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
250 MG/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Valve, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 21 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 21 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 21 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 19 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 19 |
__________________________________________________________________________|____________|
Pituitary Gland | | 20 |
__________________________________________________________________________|____________|
Thyroid Gland | | 22 |
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 20 |
__________________________________________________________________________|____________|
Ductus Deferens | | 20 |
__________________________________________________________________________|____________|
Epididymis | | 21 |
__________________________________________________________________________|____________|
Penis | | 4 |
Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | | 6 |
Inflammation, Chronic Active | | 2 4.0|
Duct, Dilatation | | 2 2.5|
__________________________________________________________________________|____________|
Prostate | | 21 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 20 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Testes | | 21 |
Germinal Epithelium, Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 21 |
Femoral, Hyperplasia | | 5 4.0|
__________________________________________________________________________|____________|
Lymph Node | | 24 |
Axillary, Hyperplasia, Plasma Cell | | 1 3.0|
Inguinal, Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
250 MG/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lumbar, Hyperplasia, Plasma Cell | | 1 4.0|
Mesenteric, Angiectasis | | 6 2.8|
Mesenteric, Cyst | | 1 |
Mesenteric, Hematopoietic Cell | | |
Proliferation | | 5 2.4|
Mesenteric, Thrombosis | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 20 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | | 26 |
Hematopoietic Cell Proliferation | | 10 3.2|
__________________________________________________________________________|____________|
Thymus | | 12 |
Cyst | | 2 |
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | |
__________________________________________________________________________|____________|
Skin | | 33 |
Hyperkeratosis | | 1 2.0|
Inflammation, Chronic Active | | 6 3.2|
Metaplasia, Osseous | | 1 3.0|
Necrosis, Coagulative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 30 |
Joint, Femur, Tibia, Metaplasia, | | |
Osseous | | 1 4.0|
Joint, Tarsal, Metaplasia, Osseous | | 15 3.9|
__________________________________________________________________________|____________|
Skeletal Muscle | | 21 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 21 |
Compression | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 25 |
Leukocytosis | | 2 |
__________________________________________________________________________|____________|
Nose | | 21 |
Inflammation, Suppurative | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
250 MG/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Suppurative | | 2 2.5|
__________________________________________________________________________|____________|
Trachea | | 21 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Lens, Cataract | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 25 |
Hyperplasia | | 1 4.0|
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 23 |
Hydronephrosis | | 5 2.6|
Infarct | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
Mineralization | | 2 1.5|
Nephropathy, Chronic | | 4 1.5|
Artery, Necrosis, Fibrinoid | | 1 3.0|
__________________________________________________________________________|____________|
Ureter | | 21 |
Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Urethra | | 15 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 21 |
Dilatation | | 5 3.8|
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 6| 6| 6| 5| 6| 5| 7| 6| 6| 7| 7| 7| 6| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 6| 6| 6| 7| 4| 5| 3| 9| 9| 3| 3| 3| 8| 3| 3| 6| 6| 2|
| 1| 1| 1| 1| 1| 0| 1| 8| 8| 8| 6| 6| 1| 1| 7| 5| 1| 1| 1| 8| 2| 2| 9| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 MG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A + + + + + + + + + + + + + + + + A M M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + + + + + + + + + + + + + + + + + A A|
Inflammation, Necrotizing | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + M + M A +|
Inflammation, Necrotizing | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + A A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + A A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | |
Hematopoietic Cell Proliferation | 2 2 2 1 2 2 2 |
Inflammation, Necrotizing | 2 |
Leukocytosis | X |
Necrosis, Coagulative | 2 3 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3|
Thrombosis | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Acinus, Atrophy | 4 |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 2 3 2 1 2 1 2 2 2 2 1 2 |
Cyst | |
Hyperkeratosis | 1 1 2 3 2 1 2 1 1 2 2 2 2 1 1 2 |
Hyperplasia, Focal | 4 4 3 4 2 |
Inflammation, Chronic Active | 2 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 2 2 |
Inflammation, Chronic Active | 2 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 6| 6| 6| 5| 6| 5| 7| 6| 6| 7| 7| 7| 6| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 6| 6| 6| 7| 4| 5| 3| 9| 9| 3| 3| 3| 8| 3| 3| 6| 6| 2|
| 1| 1| 1| 1| 1| 0| 1| 8| 8| 8| 6| 6| 1| 1| 7| 5| 1| 1| 1| 8| 2| 2| 9| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 MG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Cyst | X X |
Degeneration, Fatty | |
Hematopoietic Cell Proliferation | |
Hyperplasia | |
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + M + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + I + + + + + M + + + M + + M + +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X X |
Follicular Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Ductus Deferens | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Epididymis | M M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + |
Inflammation, Chronic Active | 3 |
Duct, Dilatation | 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + M + + + + + + + + +|
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia | 4 4 4 4 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 6| 6| 6| 5| 6| 5| 7| 6| 6| 7| 7| 7| 6| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 6| 6| 6| 7| 4| 5| 3| 9| 9| 3| 3| 3| 8| 3| 3| 6| 6| 2|
| 1| 1| 1| 1| 1| 0| 1| 8| 8| 8| 6| 6| 1| 1| 7| 5| 1| 1| 1| 8| 2| 2| 9| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 MG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Axillary, Hyperplasia, Plasma Cell | 2 |
Mediastinal, Inflammation, | |
Suppurative | 3 |
Mesenteric, Angiectasis | 3 2 2 2 2 2 2 3 |
Mesenteric, Hematopoietic Cell | |
Proliferation | 3 3 3 3 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 2 |
Pigmentation, Hemosiderin | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 3 3 3 4 3 4 4 4 2 3 2 2 4 2|
__________________________________________________________________________|
Thymus | + M + + M + + M + M + M + + + + + + M M M + M M M|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + M + + + +|
Alopecia | X X X |
Fibrosis | |
Inflammation, Chronic Active | 3 4 4 4 3 3 |
Parasite External | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Joint, Tarsal, Metaplasia, Osseous | 3 2 3 3 4 4 3 3 3 4 4 3 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukocytosis | |
Thrombosis | X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 6| 6| 6| 5| 6| 5| 7| 6| 6| 7| 7| 7| 6| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 6| 6| 6| 7| 4| 5| 3| 9| 9| 3| 3| 3| 8| 3| 3| 6| 6| 2|
| 1| 1| 1| 1| 1| 0| 1| 8| 8| 8| 6| 6| 1| 1| 7| 5| 1| 1| 1| 8| 2| 2| 9| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 MG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hydronephrosis | 2 |
Infarct | |
Inflammation, Suppurative | |
Mineralization | 2 2 |
Necrosis, Coagulative | 2 |
Nephropathy, Chronic | 1 1 1 1 1 1 1 1 2 |
__________________________________________________________________________|
Ureter | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urethra | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A|
Dilatation | 4 |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 1| 7| 7| 7| 7| 7| 7| 6| 7| 6| 4|
DAY ON TEST | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 1| 0| 3| 2| 3| 2| 9|
| 9| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 5| 4| 3| 8| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 MG/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + M + + + + + + M + + + A A + + + A M + + + A +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + M + + + + A A + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A A + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + + + + + M + + + + + + + + M + + +|
Inflammation, Necrotizing | 2|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + A A + + + A +|
Inflammation, Necrotizing | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + M M + + + A A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A A + + + A A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 3 |
Hematopoietic Cell Proliferation | 4 |
Inflammation, Necrotizing | |
Leukocytosis | X |
Necrosis, Coagulative | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Thrombosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + A + + + + + + + + + + +|
Cyst | |
Acinus, Atrophy | 1 |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 1 3 1 3 3|
Cyst | 2 |
Hyperkeratosis | 1 2 1 3 1 3 3|
Hyperplasia, Focal | 4 4 3 3 4 3 |
Inflammation, Chronic Active | 2 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 1 1 1 1 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 3 |
Inflammation, Chronic Active | 2 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 1| 7| 7| 7| 7| 7| 7| 6| 7| 6| 4|
DAY ON TEST | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 1| 0| 3| 2| 3| 2| 9|
| 9| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 5| 4| 3| 8| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 MG/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Cyst | |
Degeneration, Fatty | 2 |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia | 2 |
Hypertrophy | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + M + + + + + + M + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + M + + + + + M + + M + M +|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Ductus Deferens | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | |
Inflammation, Chronic Active | |
Duct, Dilatation | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + M|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + M + + + + + + + + + + M|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 1| 7| 7| 7| 7| 7| 7| 6| 7| 6| 4|
DAY ON TEST | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 1| 0| 3| 2| 3| 2| 9|
| 9| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 5| 4| 3| 8| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 MG/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Axillary, Hyperplasia, Plasma Cell | |
Mediastinal, Inflammation, | |
Suppurative | |
Mesenteric, Angiectasis | 2 2 3 2 3 3 3 4 2 |
Mesenteric, Hematopoietic Cell | |
Proliferation | 3 2 3 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 2 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 2 3 2 2 3 3|
__________________________________________________________________________|
Thymus | M M M M M + M M + M M + + + + M M + + M M M + + M|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | |
Fibrosis | 3 2 |
Inflammation, Chronic Active | 2 3 |
Parasite External | X X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Joint, Tarsal, Metaplasia, Osseous | 4 3 4 4 3 4 3 4 3 4 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukocytosis | X |
Thrombosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 1| 7| 7| 7| 7| 7| 7| 6| 7| 6| 4|
DAY ON TEST | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 1| 0| 3| 2| 3| 2| 9|
| 9| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 5| 4| 3| 8| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 MG/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hydronephrosis | |
Infarct | 2 |
Inflammation, Suppurative | 2 |
Mineralization | 2 |
Necrosis, Coagulative | |
Nephropathy, Chronic | 1 3 1 1 1 1 1 1 1 1 1 1 1 4 1 |
__________________________________________________________________________|
Ureter | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urethra | + + + + + + + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + A + + + + + + + + + + +|
Dilatation | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
500 MG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Gallbladder | | 39 |
__________________________________________________________________________|____________|
Intestine Large | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 47 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 44 |
Inflammation, Necrotizing | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 43 |
Inflammation, Necrotizing | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 44 |
__________________________________________________________________________|____________|
Liver | | 50 |
Degeneration, Fatty | | 1 3.0|
Hematopoietic Cell Proliferation | | 8 2.1|
Inflammation, Necrotizing | | 1 2.0|
Leukocytosis | | 2 |
Necrosis, Coagulative | | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | | 48 |
Inflammation, Chronic Active | | 2 3.0|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 49 |
Cyst | | 1 |
Acinus, Atrophy | | 2 2.5|
Duct, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Acanthosis | | 20 1.9|
Cyst | | 1 2.0|
Hyperkeratosis | | 23 1.7|
Hyperplasia, Focal | | 11 3.5|
Inflammation, Chronic Active | | 5 2.2|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Cyst | | 5 1.0|
__________________________________________________________________________|____________|
Tooth | | 50 |
Dysplasia | | 3 2.3|
Inflammation, Chronic Active | | 6 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
500 MG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 47 |
__________________________________________________________________________|____________|
Heart | | 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Accessory Adrenal Cortical Nodule | | 1 |
Cyst | | 2 |
Degeneration, Fatty | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Hyperplasia | | 1 2.0|
Hypertrophy | | 3 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Hyperplasia | | 4 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 45 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | | 41 |
Pars Distalis, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Follicle, Cyst | | 2 |
Follicular Cell, Hyperplasia | | 3 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Ductus Deferens | | 43 |
__________________________________________________________________________|____________|
Epididymis | | 47 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | | 3 |
Inflammation, Chronic Active | | 1 3.0|
Duct, Dilatation | | 2 2.0|
__________________________________________________________________________|____________|
Prostate | | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
500 MG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 3 2.7|
__________________________________________________________________________|____________|
Seminal Vesicle | | 46 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Testes | | 50 |
Seminiferous Tubule, Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Femoral, Hyperplasia | | 6 4.0|
__________________________________________________________________________|____________|
Lymph Node | | 49 |
Axillary, Hyperplasia, Plasma Cell | | 1 2.0|
Mediastinal, Inflammation, | | |
Suppurative | | 1 3.0|
Mesenteric, Angiectasis | | 17 2.5|
Mesenteric, Hematopoietic Cell | | |
Proliferation | | 17 2.4|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 49 |
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia, Plasma Cell | | 3 2.0|
Pigmentation, Hemosiderin | | 2 2.0|
__________________________________________________________________________|____________|
Spleen | | 50 |
Hematopoietic Cell Proliferation | | 23 2.9|
__________________________________________________________________________|____________|
Thymus | | 24 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | |
__________________________________________________________________________|____________|
Skin | | 49 |
Alopecia | | 3 |
Fibrosis | | 2 2.5|
Inflammation, Chronic Active | | 8 3.3|
Parasite External | | 3 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Joint, Tarsal, Metaplasia, Osseous | | 22 3.4|
__________________________________________________________________________|____________|
Skeletal Muscle | | 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05038-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:50:27
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
500 MG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Leukocytosis | | 1 |
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Nose | | 50 |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 48 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Cyst | | 1 |
Hydronephrosis | | 1 2.0|
Infarct | | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
Mineralization | | 3 2.0|
Necrosis, Coagulative | | 1 2.0|
Nephropathy, Chronic | | 24 1.3|
__________________________________________________________________________|____________|
Ureter | | 43 |
__________________________________________________________________________|____________|
Urethra | | 29 |
__________________________________________________________________________|____________|
Urinary Bladder | | 48 |
Dilatation | | 1 4.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
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