TR 354 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/05/94
EXP: 05038 DIMETHOXANE TIME: 09:14:22
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56213
CONT: N01CP9565302 CAS: 828-00-2
PATHOLOGIST: J. TOFT S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/05/94
EXP: 05038 DIMETHOXANE TIME: 09:14:22
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56213
CONT: N01CP9565302 CAS: 828-00-2
PATHOLOGIST: J. TOFT S. EUSTIS
DIMETHOXANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 17 CENSORED DEATHS 10 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 109 509 519 530 542 549 549 600 616 664 |
| 665 666 684 689 720 724 729 |
| CENSORED DEATHS |
| 458 458 458 458 458 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 250 MG/ KG |
| --------------------- |
| |
| TOTAL 58 UNCENSORED DEATHS 21 CENSORED DEATHS 10 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 30 102 225 283 446 448 478 509 537 549 |
| 551 555 605 611 613 662 667 675 682 688 |
| 689 |
| CENSORED DEATHS |
| 458 458 458 458 458 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 500 MG/ KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 21 CENSORED DEATHS 10 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 186 302 423 469 493 549 550 551 576 623 |
| 628 646 668 668 668 669 688 695 697 704 |
| 715 |
| CENSORED DEATHS |
| 458 458 458 458 458 458 458 458 458 458 |
| |
==================================================================================
DIMETHOXANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 731 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 98.3 98.3 98.3 98.3 98.3 90.3 84.3 78.3 66.2 |
| | |
| | |
|250 MG/ KG | 98.3 96.6 94.8 93.1 93.1 87.5 83.3 74.7 68.3 57.6 |
| | |
| | |
|500 MG/ KG | 100.0 100.0 98.3 96.7 95.0 93.0 91.0 82.9 76.8 58.6 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 250 MG/ KG 500 MG/ KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 66.2% 57.6% 58.6% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.479 P=0.303 P=0.509 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 592.0 505.0 579.4 |
|NATURAL DEATHS (C) | (35.5) (42.0) (30.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 646.1 602.1 632.5 |
|(STANDARD ERROR) | (16.7) (22.0) (17.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DIMETHOXANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 14 CENSORED DEATHS 10 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 409 462 539 574 584 596 596 603 628 629 |
| 633 697 722 724 |
| CENSORED DEATHS |
| 458 458 458 458 458 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 250 MG/ KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 14 CENSORED DEATHS 11 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 336 454 601 602 614 617 623 635 639 659 |
| 680 689 710 711 |
| CENSORED DEATHS |
| 19 458 458 458 458 458 458 458 458 458 |
| 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 500 MG/ KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 16 CENSORED DEATHS 10 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 196 282 474 493 509 584 634 646 653 654 |
| 655 673 680 688 688 709 |
| CENSORED DEATHS |
| 458 458 458 458 458 458 458 458 458 458 |
| |
==================================================================================
DIMETHOXANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 731 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 100.0 98.3 96.3 94.3 84.3 78.3 72.2 |
| | |
| | |
|250 MG/ KG | 100.0 100.0 100.0 98.3 98.3 96.6 96.6 92.5 80.2 71.9 |
| | |
| | |
|500 MG/ KG | 100.0 100.0 98.3 96.7 96.7 94.7 90.6 88.6 78.5 68.5 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 250 MG/ KG 500 MG/ KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 72.2% 71.9% 68.5% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.768 P=1.000N P=0.837 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 599.7 612.1 576.1 |
|NATURAL DEATHS (C) | (23.7) (27.2) (37.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 654.9 645.9 644.2 |
|(STANDARD ERROR) | (14.5) (18.0) (17.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DIMETHOXANE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
250 MG/ KG = 2
500 MG/ KG = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1 3
| 2 21 3 3 1
|
| 2 2 3 3 1 1
95 + 2 2 3 3
| 11
| 2 2 3 3 1 1
| 3 3
90 + 2 2 11
|
P | 2 2
E | 1 1
R 85 + 2 2 3 3
C | 2 2 1 1
E | 3 13 1
N | 33
T 80 +
| 22 3 3 11
S |
U | 2 2 3 1 1
R 75 + 22
V | 11
I | 1 1
V |
A 70 + 2 2 11
L | 22 3 1 1
|
| 22 33 1
65 +
| 22
| 2233
| 3 3
60 +
| 3 3
| 2 2
|
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 4 obs hidden.
DIMETHOXANE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
250 MG/ KG = 2
500 MG/ KG = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 2 1
| 3 3 2 1 21
|
| 3 21 3 1 2
95 + 3 3
| 1 1
P | 3 3 1 1 2 2
E | 3 3
R 90 + 1 1 22
C | 3 3
E |
N | 11 2 2 3
T 85 + 33
| 1 122
S | 2 2
U |
R 80 + 11 2 2
V | 1 3 3 1
I | 22
V | 3321 2 1
A 75 + 33
L |
| 2 1 1
|
70 + 3 3
| 3 3
|
|
65 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 4 obs hidden.
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