TR 354 Rat Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
DIMETHOXANE
NTP Experiment-Test: 05038-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/05/94
Route: GAVAGE Time: 07:33:28
Facility: Battelle Columbus Laboratory
Chemical CAS #: 828-00-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05038-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIMETHOXANE Date: 09/05/94
Route: GAVAGE Time: 07:33:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 125 MG/ 250 MG/
KG KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund 12 13 13
Dead 6 3 2
Dosing Accident 2 3 11
Survivors
Terminal Sacrifice 30 31 24
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50)
Foreign Body 1 (2%)
Hemorrhage, Acute 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 3 (6%)
Perforation 1 (2%)
Intestine Large, Cecum (44) (47) (45)
Concretion 1 (2%)
Inflammation, Chronic Active 1 (2%)
Parasite Metazoan 1 (2%) 1 (2%)
Intestine Large, Colon (48) (50) (50)
Diverticulum 1 (2%)
Parasite Metazoan 1 (2%) 4 (8%)
Intestine Large, Rectum (47) (47) (46)
Parasite Metazoan 4 (9%) 4 (9%) 2 (4%)
Liver (50) (49) (50)
Basophilic Focus 40 (80%) 35 (71%) 34 (68%)
Clear Cell Focus 3 (6%) 3 (6%) 3 (6%)
Degeneration, Cystic 1 (2%)
Eosinophilic Focus 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hepatodiaphragmatic Nodule 6 (12%) 4 (8%)
Inflammation, Chronic 23 (46%) 18 (37%) 21 (42%)
Inflammation, Necrotizing 1 (2%)
Necrosis, Coagulative 1 (2%)
Vacuolization Cytoplasmic 2 (4%)
Mesentery (47) (46) (49)
Inflammation, Chronic Active 2 (4%) 1 (2%) 1 (2%)
Mineralization 1 (2%)
Pancreas (50) (50) (50)
Acinus, Atrophy 14 (28%) 19 (38%) 12 (24%)
Salivary Glands (48) (50) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05038-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIMETHOXANE Date: 09/05/94
Route: GAVAGE Time: 07:33:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 125 MG/ 250 MG/
KG KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Chronic Active 1 (2%)
Acinus, Atrophy 1 (2%)
Duct, Hyperplasia 1 (2%)
Stomach, Forestomach (50) (50) (50)
Acanthosis, Diffuse 3 (6%)
Acanthosis, Focal 8 (16%) 41 (82%)
Hyperkeratosis, Diffuse 10 (20%)
Hyperkeratosis, Focal 5 (10%) 12 (24%)
Hyperplasia, Focal 1 (2%) 3 (6%)
Inflammation, Chronic Active 1 (2%) 3 (6%)
Ulcer 3 (6%)
Stomach, Glandular (50) (49) (50)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (49) (50) (50)
Inflammation, Chronic Active 1 (2%)
Heart (50) (50) (50)
Bacterium, Multiple 1 (2%) 1 (2%)
Cardiomyopathy, Chronic 37 (74%) 33 (66%) 32 (64%)
Foreign Body 1 (2%) 2 (4%)
Infarct 1 (2%)
Inflammation, Chronic Active 3 (6%) 6 (12%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50)
Degeneration, Fatty 3 (6%) 13 (26%) 7 (14%)
Hyperplasia 17 (34%) 20 (40%) 18 (36%)
Hypertrophy 1 (2%) 1 (2%)
Necrosis, Coagulative 1 (2%) 4 (8%)
Adrenal Gland, Medulla (50) (50) (49)
Hyperplasia 5 (10%) 5 (10%) 8 (16%)
Parathyroid Gland (46) (43) (42)
Cyst 1 (2%)
Hyperplasia 2 (5%)
Pituitary Gland (48) (49) (50)
Pars Distalis, Cyst 19 (40%) 21 (43%) 28 (56%)
Pars Distalis, Hemorrhage, Acute 1 (2%)
Pars Distalis, Hyperplasia 20 (42%) 18 (37%) 15 (30%)
Pars Distalis, Pigmentation, Hemosiderin 4 (8%)
Pars Intermedia, Cyst 1 (2%)
Thyroid Gland (50) (50) (50)
Hemorrhage, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05038-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIMETHOXANE Date: 09/05/94
Route: GAVAGE Time: 07:33:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 125 MG/ 250 MG/
KG KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Inflammation, Chronic Active 2 (4%)
C-Cell, Hyperplasia 26 (52%) 24 (48%) 27 (54%)
Follicle, Cyst 1 (2%)
Follicular Cell, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (47) (46) (48)
Fibrosis 1 (2%)
Hyperplasia 5 (11%) 7 (15%) 2 (4%)
Inflammation, Chronic Active 1 (2%) 3 (7%) 7 (15%)
Necrosis, Caseous 2 (4%)
Duct, Dilatation 2 (4%)
Ovary (50) (49) (50)
Atrophy 3 (6%) 1 (2%)
Cyst 3 (6%) 4 (8%) 2 (4%)
Uterus (50) (49) (50)
Dilatation 5 (10%) 5 (10%) 2 (4%)
Diverticulum 1 (2%)
Hemorrhage 2 (4%) 1 (2%)
Inflammation, Chronic Active 3 (6%)
Prolapse 1 (2%)
Endometrium, Hyperplasia, Cystic, Glandular 2 (4%) 6 (12%) 8 (16%)
Vagina (2) (1)
Inflammation, Chronic Active 1 (100%)
Prolapse 1 (50%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Femoral, Hyperplasia, Reticulum Cell 5 (10%) 1 (2%) 2 (4%)
Lymph Node (50) (50) (50)
Inguinal, Cyst 1 (2%)
Mediastinal, Hyperplasia, Lymphoid 1 (2%)
Mediastinal, Hyperplasia, Plasma Cell 1 (2%)
Mediastinal, Inflammation, Chronic Active 1 (2%)
Mediastinal, Lymphocyte, Necrosis, Acute 1 (2%)
Mesenteric, Hemorrhage, Acute 1 (2%)
Pancreatic, Thrombosis 1 (2%)
Spleen (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05038-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIMETHOXANE Date: 09/05/94
Route: GAVAGE Time: 07:33:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 125 MG/ 250 MG/
KG KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 3 (6%) 3 (6%) 4 (8%)
Hyperplasia, Lymphoid 1 (2%)
Hyperplasia, Reticulum Cell 1 (2%)
Infarct, Chronic 1 (2%)
Thymus (41) (38) (41)
Cyst 3 (7%) 2 (5%)
Hyperplasia, Lymphoid 1 (2%)
Necrosis 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (47) (50) (47)
Cyst 2 (4%)
Hyperplasia, Cystic 47 (100%) 49 (98%) 43 (91%)
Skin (50) (50) (50)
Acanthosis 1 (2%)
Cyst Epithelial Inclusion 1 (2%)
Edema 1 (2%)
Hyperkeratosis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (50)
Compression 5 (10%) 8 (16%) 4 (8%)
Hemorrhage, Acute 3 (6%) 2 (4%) 2 (4%)
Hydrocephalus 1 (2%) 9 (18%) 4 (8%)
Pigmentation, Hemosiderin 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Bacterium 1 (2%)
Foreign Body 2 (4%) 4 (8%) 6 (12%)
Inflammation, Chronic 12 (24%) 11 (22%) 11 (22%)
Alveolar Epithelium, Hyperplasia 3 (6%) 2 (4%)
Mediastinum, Bacterium, Multiple 1 (2%) 1 (2%)
Mediastinum, Foreign Body 1 (2%)
Mediastinum, Hemorrhage, Acute 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05038-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIMETHOXANE Date: 09/05/94
Route: GAVAGE Time: 07:33:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 125 MG/ 250 MG/
KG KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Mediastinum, Inflammation, Chronic Active 1 (2%) 7 (14%)
Pleura, Hyperplasia 1 (2%)
Nose (50) (50) (50)
Foreign Body 1 (2%) 7 (14%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 5 (10%) 3 (6%)
Nasolacrimal Duct, Inflammation, Suppurative 2 (4%) 3 (6%) 2 (4%)
Trachea (50) (50) (50)
Foreign Body 1 (2%)
Hemorrhage, Acute 1 (2%)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (2) (4)
Hemorrhage, Acute 1 (50%)
Lens, Cataract 1 (50%) 2 (100%) 2 (50%)
Retina, Atrophy 1 (50%) 2 (100%) 2 (50%)
Harderian Gland (49) (49) (49)
Atrophy 1 (2%)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Cyst 1 (2%) 1 (2%)
Infarct, Chronic 1 (2%) 1 (2%)
Mineralization 3 (6%) 2 (4%) 1 (2%)
Nephropathy, Chronic 38 (76%) 35 (70%) 26 (52%)
Urinary Bladder (49) (48) (48)
Dilatation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05038-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIMETHOXANE Date: 09/05/94
Route: GAVAGE Time: 07:33:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 62.5 MG/ 125 MG/
KG KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund 21 15 12
Dead 4 4 6
Dosing Accident 2 3 11
Survivors
Terminal Sacrifice 23 28 21
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (49) (50) (50)
Hemorrhage, Acute 1 (2%)
Inflammation, Chronic Active 2 (4%) 2 (4%)
Intestine Large, Colon (50) (49) (49)
Parasite Metazoan 3 (6%) 3 (6%)
Intestine Large, Rectum (49) (47) (47)
Parasite Metazoan 6 (12%) 7 (15%) 3 (6%)
Intestine Small, Ileum (50) (45) (45)
Inflammation, Chronic Active 1 (2%)
Liver (50) (50) (50)
Basophilic Focus 24 (48%) 17 (34%) 18 (36%)
Clear Cell Focus 1 (2%) 2 (4%)
Degeneration, Cystic 2 (4%) 1 (2%) 3 (6%)
Hematopoietic Cell Proliferation 1 (2%)
Hepatodiaphragmatic Nodule 2 (4%) 1 (2%) 2 (4%)
Hyperplasia, Nodular 1 (2%)
Inflammation, Chronic 11 (22%) 6 (12%) 13 (26%)
Inflammation, Necrotizing 1 (2%) 2 (4%)
Necrosis, Coagulative 1 (2%) 1 (2%) 1 (2%)
Vacuolization Cytoplasmic 1 (2%) 2 (4%)
Mesentery (49) (49) (46)
Hemorrhage, Chronic 1 (2%) 1 (2%)
Inflammation, Chronic Active 4 (8%) 13 (27%) 9 (20%)
Mineralization 3 (6%) 5 (11%)
Necrosis 1 (2%)
Pancreas (50) (50) (50)
Ectopic Tissue 1 (2%)
Inflammation, Chronic Active 2 (4%) 1 (2%)
Acinus, Atrophy 18 (36%) 22 (44%) 21 (42%)
Acinus, Hyperplasia 2 (4%) 1 (2%)
Duct, Ectasia 1 (2%) 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05038-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIMETHOXANE Date: 09/05/94
Route: GAVAGE Time: 07:33:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 62.5 MG/ 125 MG/
KG KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Stomach, Forestomach (50) (50) (50)
Acanthosis, Focal 5 (10%) 9 (18%) 23 (46%)
Edema 1 (2%)
Hyperkeratosis, Diffuse 2 (4%)
Hyperkeratosis, Focal 1 (2%) 8 (16%)
Hyperplasia, Focal 2 (4%) 1 (2%) 3 (6%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Ulcer 1 (2%)
Stomach, Glandular (50) (49) (50)
Inflammation, Chronic Active 1 (2%)
Tooth (50) (49) (50)
Dysplasia 1 (2%)
Inflammation, Chronic Active 2 (4%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
Cardiomyopathy, Chronic 45 (90%) 48 (96%) 46 (92%)
Foreign Body 2 (4%)
Inflammation, Chronic Active 2 (4%) 3 (6%)
Atrium, Thrombosis 1 (2%) 5 (10%) 1 (2%)
Coronary Artery, Inflammation, Chronic Active 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (49)
Accessory Adrenal Cortical Nodule 1 (2%)
Atrophy 1 (2%)
Degeneration, Fatty 5 (10%) 7 (14%) 7 (14%)
Hyperplasia 12 (24%) 19 (38%) 18 (37%)
Hypertrophy 1 (2%) 2 (4%)
Necrosis, Coagulative 1 (2%)
Adrenal Gland, Medulla (50) (50) (50)
Hyperplasia 13 (26%) 18 (36%) 13 (26%)
Islets, Pancreatic (49) (50) (50)
Hyperplasia 1 (2%)
Pituitary Gland (49) (50) (49)
Pars Distalis, Cyst 6 (12%) 6 (12%) 9 (18%)
Pars Distalis, Hemorrhage, Acute 1 (2%)
Pars Distalis, Hyperplasia 9 (18%) 8 (16%) 11 (22%)
Pars Intermedia, Cyst 1 (2%)
Thyroid Gland (50) (50) (50)
Inflammation, Chronic Active 1 (2%)
C-Cell, Hyperplasia 14 (28%) 16 (32%) 14 (28%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05038-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIMETHOXANE Date: 09/05/94
Route: GAVAGE Time: 07:33:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 62.5 MG/ 125 MG/
KG KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Follicle, Cyst 1 (2%)
Follicular Cell, Hyperplasia 5 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Hemorrhage, Acute 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (48) (50) (50)
Inflammation, Chronic Active 2 (4%)
Preputial Gland (48) (47) (49)
Hyperplasia 2 (4%) 4 (9%) 1 (2%)
Inflammation, Chronic Active 45 (94%) 43 (91%) 42 (86%)
Duct, Ectasia 2 (4%)
Prostate (50) (50) (50)
Cyst 1 (2%) 2 (4%)
Inflammation, Chronic Active 24 (48%) 23 (46%) 22 (44%)
Seminal Vesicle (48) (49) (48)
Inflammation, Chronic Active 1 (2%)
Testes (50) (50) (50)
Cyst 1 (2%)
Hemorrhage, Chronic 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 8 (16%) 16 (32%) 7 (14%)
Interstitial Cell, Hyperplasia 27 (54%) 33 (66%) 33 (66%)
Seminiferous Tubule, Atrophy 40 (80%) 38 (76%) 34 (68%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Femoral, Hyperplasia, Reticulum Cell 1 (2%) 2 (4%)
Femoral, Myelofibrosis 2 (4%)
Lymph Node (50) (50) (50)
Mediastinal, Cyst 1 (2%)
Mediastinal, Edema, Acute 1 (2%)
Mediastinal, Hemorrhage, Acute 1 (2%)
Lymph Node, Mandibular (50) (50) (49)
Cyst 6 (12%) 2 (4%)
Hyperplasia, Plasma Cell 1 (2%)
Spleen (50) (50) (50)
Fibrosis 3 (6%) 2 (4%) 2 (4%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05038-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIMETHOXANE Date: 09/05/94
Route: GAVAGE Time: 07:33:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 62.5 MG/ 125 MG/
KG KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Infarct, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (42) (43) (42)
Hyperplasia, Cystic 38 (90%) 43 (100%) 39 (93%)
Inflammation, Chronic Active 1 (2%)
Skin (50) (50) (50)
Acanthosis 1 (2%) 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Hyperkeratosis 2 (4%) 3 (6%) 2 (4%)
Inflammation, Chronic Active 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Compression 7 (14%) 3 (6%) 4 (8%)
Hemorrhage, Acute 3 (6%) 1 (2%) 1 (2%)
Hydrocephalus 7 (14%) 3 (6%) 3 (6%)
Necrosis 1 (2%)
Spinal Cord (1)
White Matter, Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Bacterium, Multiple 1 (2%)
Foreign Body 2 (4%) 6 (12%) 9 (18%)
Inflammation, Chronic 21 (42%) 11 (22%) 15 (30%)
Alveolar Epithelium, Hyperplasia 4 (8%) 5 (10%) 3 (6%)
Mediastinum, Hemorrhage, Acute 1 (2%)
Mediastinum, Inflammation, Chronic Active 2 (4%) 4 (8%)
Nose (50) (48) (50)
Fibrosis 1 (2%)
Foreign Body 9 (19%)
Inflammation, Chronic Active 2 (4%) 6 (13%) 1 (2%)
Nasolacrimal Duct, Inflammation, Chronic
Active 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 3 (6%) 3 (6%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05038-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIMETHOXANE Date: 09/05/94
Route: GAVAGE Time: 07:33:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 62.5 MG/ 125 MG/
KG KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Trachea (49) (50) (50)
Hemorrhage, Acute 1 (2%)
Inflammation, Chronic Active 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1)
Acanthosis 1 (100%)
Hyperkeratosis 1 (100%)
Eye (3) (2) (5)
Lens, Cataract 3 (100%) 1 (50%) 1 (20%)
Retina, Atrophy 3 (100%) 1 (50%) 1 (20%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Cyst 1 (2%) 2 (4%)
Hemorrhage, Chronic 1 (2%)
Infarct, Chronic 1 (2%)
Inflammation, Necrotizing 1 (2%)
Mineralization 1 (2%)
Nephropathy, Chronic 47 (94%) 49 (98%) 47 (94%)
Urinary Bladder (49) (49) (49)
Dilatation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
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