TR 354 Rat Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
DIMETHOXANE
NTP Experiment-Test: 05038-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/05/94
Route: GAVAGE Time: 07:33:29
Facility: Battelle Columbus Laboratory
Chemical CAS #: 828-00-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05038-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIMETHOXANE Date: 09/05/94
Route: GAVAGE Time: 07:33:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 125 MG/ 250 MG/
KG KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund 12 13 13
Dead 6 3 2
Dosing Accident 2 3 11
Survivors
Terminal Sacrifice 30 31 24
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (50) (49) (50)
Histiocytic Sarcoma 1 (2%)
Neoplastic Nodule 1 (2%) 1 (2%)
Mesentery (47) (46) (49)
Pancreas (50) (50) (50)
Salivary Glands (48) (50) (49)
Stomach, Forestomach (50) (50) (50)
Squamous Cell Papilloma, Multiple 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50)
Adenoma 1 (2%) 2 (4%)
Bilateral, Adenoma 1 (2%)
Medulla, Granulosa-Theca Tumor Malignant,
Metastatic, Ovary 1 (2%)
Adrenal Gland, Medulla (50) (50) (49)
Pheochromocytoma Benign 2 (4%)
Islets, Pancreatic (50) (50) (50)
Adenoma 1 (2%)
Pituitary Gland (48) (49) (50)
Pars Distalis, Adenoma 13 (27%) 13 (27%) 7 (14%)
Thyroid Gland (50) (50) (50)
Bilateral, C-Cell, Adenoma 1 (2%) 1 (2%) 1 (2%)
Page 2
NTP Experiment-Test: 05038-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIMETHOXANE Date: 09/05/94
Route: GAVAGE Time: 07:33:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 125 MG/ 250 MG/
KG KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
C-Cell, Adenoma 12 (24%) 11 (22%) 6 (12%)
C-Cell, Carcinoma 2 (4%) 1 (2%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (47) (46) (48)
Adenoma 1 (2%)
Ovary (50) (49) (50)
Granulosa-Theca Tumor Malignant 1 (2%)
Granulosa-Theca Tumor Benign 1 (2%)
Histiocytic Sarcoma 1 (2%)
Uterus (50) (49) (50)
Adenocarcinoma 1 (2%) 1 (2%)
Polyp Stromal 5 (10%) 3 (6%) 2 (4%)
Polyp Stromal, Multiple 1 (2%)
Sarcoma Stromal 2 (4%)
Vagina (2) (1)
Polyp 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Lymph Node (50) (50) (50)
Lymph Node, Mandibular (47) (50) (49)
Spleen (50) (50) (50)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (47) (50) (47)
Adenoma 2 (4%) 1 (2%)
Fibroadenoma 12 (26%) 10 (20%) 10 (21%)
Fibroadenoma, Multiple 2 (4%) 1 (2%) 3 (6%)
Skin (50) (50) (50)
Basal Cell Carcinoma 1 (2%)
Granulosa-Theca Tumor Malignant, Metastatic,
Ovary 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
Page 3
NTP Experiment-Test: 05038-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIMETHOXANE Date: 09/05/94
Route: GAVAGE Time: 07:33:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 125 MG/ 250 MG/
KG KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (50)
Astrocytoma Malignant 1 (2%)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Basal Cell Carcinoma, Metastatic, Skin 1 (2%)
Granulosa-Theca Tumor Malignant, Metastatic,
Ovary 1 (2%)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Urinary Bladder (49) (48) (48)
Papilloma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 12 (24%) 14 (28%) 12 (24%)
Lymphoma Malignant Histiocytic 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 05038-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIMETHOXANE Date: 09/05/94
Route: GAVAGE Time: 07:33:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 125 MG/ 250 MG/
KG KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 41 37 32
Total Primary Neoplasms 71 63 56
Total Animals with Benign Neoplasms 35 28 26
Total Benign Neoplasms 54 42 37
Total Animals with Malignant Neoplasms 14 20 16
Total Malignant Neoplasms 17 21 19
Total Animals with Metastatic Neoplasms 2
Total Metastatic Neoplasm 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 5
NTP Experiment-Test: 05038-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIMETHOXANE Date: 09/05/94
Route: GAVAGE Time: 07:33:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 62.5 MG/ 125 MG/
KG KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund 21 15 12
Dead 4 4 6
Dosing Accident 2 3 11
Survivors
Terminal Sacrifice 23 28 21
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (49) (47) (47)
Intestine Small, Ileum (50) (45) (45)
Intestine Small, Jejunum (49) (50) (49)
Liver (50) (50) (50)
Neoplastic Nodule 1 (2%)
Mesentery (49) (49) (46)
Pancreas (50) (50) (50)
Acinus, Adenoma, Multiple 1 (2%)
Salivary Glands (50) (50) (50)
Stomach, Forestomach (50) (50) (50)
Squamous Cell Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (49)
Adenoma 1 (2%)
Carcinoma 1 (2%) 1 (2%) 1 (2%)
Adrenal Gland, Medulla (50) (50) (50)
Pheochromocytoma Benign 5 (10%) 9 (18%) 4 (8%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (49) (50) (50)
Adenoma 2 (4%) 1 (2%)
Adenoma, Multiple 1 (2%)
Carcinoma 1 (2%)
Page 6
NTP Experiment-Test: 05038-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIMETHOXANE Date: 09/05/94
Route: GAVAGE Time: 07:33:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 62.5 MG/ 125 MG/
KG KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Parathyroid Gland (49) (46) (47)
Adenoma 2 (4%)
Pituitary Gland (49) (50) (49)
Pars Distalis, Adenoma 13 (27%) 7 (14%) 11 (22%)
Thyroid Gland (50) (50) (50)
Bilateral, C-Cell, Adenoma 1 (2%) 2 (4%) 2 (4%)
C-Cell, Adenoma 12 (24%) 10 (20%) 8 (16%)
C-Cell, Carcinoma 2 (4%) 2 (4%)
Follicular Cell, Adenoma 3 (6%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (48) (50) (50)
Preputial Gland (48) (47) (49)
Adenoma 2 (4%) 2 (4%)
Prostate (50) (50) (50)
Seminal Vesicle (48) (49) (48)
Testes (50) (50) (50)
Bilateral, Interstitial Cell, Adenoma 32 (64%) 34 (68%) 33 (66%)
Interstitial Cell, Adenoma 13 (26%) 9 (18%) 11 (22%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Lymph Node (50) (50) (50)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Lymph Node, Mandibular (50) (50) (49)
Squamous Cell Carcinoma, Metastatic, Skin 1 (2%)
Spleen (50) (50) (50)
Leiomyosarcoma 1 (2%)
Thymus (38) (40) (38)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (42) (43) (42)
Fibroadenoma 1 (2%) 1 (2%) 2 (5%)
Skin (50) (50) (50)
Keratoacanthoma 1 (2%) 3 (6%) 2 (4%)
Page 7
NTP Experiment-Test: 05038-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIMETHOXANE Date: 09/05/94
Route: GAVAGE Time: 07:33:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 62.5 MG/ 125 MG/
KG KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Lipoma 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Sebaceous Gland, Adenoma 1 (2%)
Subcutaneous Tissue, Fibroma 2 (4%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Astrocytoma Malignant 1 (2%)
Granular Cell Tumor Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Alveolar/Bronchiolar Adenoma 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Nose (50) (48) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Carcinoma 1 (2%)
Urinary Bladder (49) (49) (49)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 19 (38%) 14 (28%) 9 (18%)
Mesothelioma Malignant 2 (4%) 1 (2%) 1 (2%)
* Number of animals with any tissue examined microscopically
Page 8
NTP Experiment-Test: 05038-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIMETHOXANE Date: 09/05/94
Route: GAVAGE Time: 07:33:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 62.5 MG/ 125 MG/
KG KG
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(50) *(50) *(50)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05038-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIMETHOXANE Date: 09/05/94
Route: GAVAGE Time: 07:33:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 62.5 MG/ 125 MG/
KG KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 47 48
Total Primary Neoplasms 115 111 95
Total Animals with Benign Neoplasms 50 45 48
Total Benign Neoplasms 89 87 78
Total Animals with Malignant Neoplasms 24 23 16
Total Malignant Neoplasms 26 24 17
Total Animals with Metastatic Neoplasms 4
Total Metastatic Neoplasm 4
Total Animals with Malignant Neoplasms 2
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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