TR 354 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus DIMETHOXANE DATE: 09/05/94
EXPERIMENT: 05038 TEST: 01 TIME: 07:44:49
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01CP9565302 ROUTE: GAVAGE NTP C#: 56213
PATHOLOGIST: J. TOFT S. EUSTIS CAS: 828-00-2
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus DIMETHOXANE DATE: 09/05/94
EXPERIMENT: 05038 TEST: 01 TIME: 07:44:49
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01CP9565302 ROUTE: GAVAGE NTP C#: 56213
PATHOLOGIST: J. TOFT S. EUSTIS CAS: 828-00-2
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus DIMETHOXANE DATE: 09/05/94
EXPERIMENT: 05038 TEST: 01 TIME: 07:44:49
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01CP9565302 ROUTE: GAVAGE NTP C#: 56213
PATHOLOGIST: J. TOFT S. EUSTIS CAS: 828-00-2
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF DIMETHOXANE
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Thyroid Gland: Follicular Cell
Carcinoma or Adenoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear,
or Undifferentiated
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
All Organs Benign Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/05/94 EXPERIMENT: 05038 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIMETHOXANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 62.5 MG/ 125 MG/ | 0 MG/KG 125 MG/ 250 MG/ |
| | KG KG | KG KG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/49 (0%) | 1/50 (2%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 3.6% 0.0% | 3.3% 3.2% 8.3% |
|TERMINAL (d) | 0/23 (0%) 1/28 (4%) 0/21 (0%) | 1/30 (3%) 1/31 (3%) 2/24 (8%) |
|FIRST INCIDENCE (DAYS) | --- 730 (T) --- | 730 (T) 730 (T) 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.727 P=0.539 (e) | P=0.308 P=0.755N P=0.422 |
|INCIDENTAL TUMOR | P=0.727 P=0.539 (e) | P=0.308 P=0.755N P=0.422 |
|LOGISTIC REGRESSION | P=0.727 P=0.539 (e) | P=0.308 P=0.755N P=0.422 |
|COCHRAN-ARMITAGE | P=0.728 | P=0.378 |
|FISHER EXACT | P=0.500 (e) | P=0.753N P=0.500 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 10/50 (20%) 4/50 (8%) | 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 17.3% 30.8% 17.1% | 6.5% 0.0% 0.0% |
|TERMINAL (d) | 3/23 (13%) 7/28 (25%) 3/21 (14%) | 1/30 (3%) 0/31 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 571 563 634 | 723 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.539N P=0.201 P=0.593N | P=0.113N P=0.226N P=0.294N |
|INCIDENTAL TUMOR | P=0.336N P=0.114 P=0.385N | P=0.089N P=0.186N P=0.243N |
|LOGISTIC REGRESSION | P=0.533N P=0.127 P=0.582N | P=0.106N P=0.213N P=0.286N |
|COCHRAN-ARMITAGE | P=0.440N | P=0.095N |
|FISHER EXACT | P=0.131 P=0.500N | P=0.247N P=0.247N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05038 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIMETHOXANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 62.5 MG/ 125 MG/ | 0 MG/KG 125 MG/ 250 MG/ |
| | KG KG | KG KG |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/48 (0%) 2/47 (4%) 2/49 (4%) | 1/47 (2%) 0/46 (0%) 0/48 (0%) |
|ADJUSTED (b) | 0.0% 6.2% 4.7% | 2.6% 0.0% 0.0% |
|TERMINAL (d) | 0/21 (0%) 1/27 (4%) 0/21 (0%) | 0/27 (0%) 0/29 (0%) 0/22 (0%) |
|FIRST INCIDENCE (DAYS) | --- 641 515 | 625 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.152 P=0.264 P=0.224 | P=0.296N P=0.500N P=0.546N |
|INCIDENTAL TUMOR | P=0.288 P=0.213 P=0.320 | P=0.312N P=0.718N P=0.523N |
|LOGISTIC REGRESSION | P=0.203 P=0.231 P=0.308 | P=0.260N P=0.515N P=0.492N |
|COCHRAN-ARMITAGE | P=0.182 | P=0.268N |
|FISHER EXACT | P=0.242 P=0.253 | P=0.505N P=0.495N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/48 (0%) 2/47 (4%) 2/49 (4%) | 1/47 (2%) 0/46 (0%) 0/48 (0%) |
|ADJUSTED (b) | 0.0% 6.2% 4.7% | 2.6% 0.0% 0.0% |
|TERMINAL (d) | 0/21 (0%) 1/27 (4%) 0/21 (0%) | 0/27 (0%) 0/29 (0%) 0/22 (0%) |
|FIRST INCIDENCE (DAYS) | --- 641 515 | 625 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.152 P=0.264 P=0.224 | P=0.296N P=0.500N P=0.546N |
|INCIDENTAL TUMOR | P=0.288 P=0.213 P=0.320 | P=0.312N P=0.718N P=0.523N |
|LOGISTIC REGRESSION | P=0.203 P=0.231 P=0.308 | P=0.260N P=0.515N P=0.492N |
|COCHRAN-ARMITAGE | P=0.182 | P=0.268N |
|FISHER EXACT | P=0.242 P=0.253 | P=0.505N P=0.495N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05038 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIMETHOXANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 62.5 MG/ 125 MG/ | 0 MG/KG 125 MG/ 250 MG/ |
| | KG KG | KG KG |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/49 (6%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 11.9% 3.4% 0.0% | 0.0% 0.0% 4.2% |
|TERMINAL (d) | 1/22 (5%) 0/28 (0%) 0/21 (0%) | 0/30 (0%) 0/31 (0%) 1/24 (4%) |
|FIRST INCIDENCE (DAYS) | 726 724 --- | --- --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.072N P=0.265N P=0.152N | P=0.236 (e) P=0.455 |
|INCIDENTAL TUMOR | P=0.138N P=0.402N P=0.232N | P=0.236 (e) P=0.455 |
|LOGISTIC REGRESSION | P=0.070N P=0.253N P=0.156N | P=0.236 (e) P=0.455 |
|COCHRAN-ARMITAGE | P=0.058N | P=0.269 |
|FISHER EXACT | P=0.301N P=0.117N | (e) P=0.500 |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/49 (6%) 1/50 (2%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 11.9% 3.4% 3.4% | 0.0% 0.0% 4.2% |
|TERMINAL (d) | 1/22 (5%) 0/28 (0%) 0/21 (0%) | 0/30 (0%) 0/31 (0%) 1/24 (4%) |
|FIRST INCIDENCE (DAYS) | 726 724 635 | --- --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.248N P=0.265N P=0.378N | P=0.236 (e) P=0.455 |
|INCIDENTAL TUMOR | P=0.292N P=0.402N P=0.386N | P=0.236 (e) P=0.455 |
|LOGISTIC REGRESSION | P=0.235N P=0.253N P=0.360N | P=0.236 (e) P=0.455 |
|COCHRAN-ARMITAGE | P=0.196N | P=0.269 |
|FISHER EXACT | P=0.301N P=0.301N | (e) P=0.500 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05038 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIMETHOXANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 62.5 MG/ 125 MG/ | 0 MG/KG 125 MG/ 250 MG/ |
| | KG KG | KG KG |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 8.7% 0.0% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/23 (9%) 0/28 (0%) 0/21 (0%) | 0/30 (0%) 0/31 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 730 (T) --- --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.094N P=0.195N P=0.257N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.094N P=0.195N P=0.257N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.094N P=0.195N P=0.257N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.095N | (e) |
|FISHER EXACT | P=0.247N P=0.247N | (e) (e) |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 8.7% 0.0% 4.8% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/23 (9%) 0/28 (0%) 1/21 (5%) | 0/30 (0%) 0/31 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 730 (T) --- 730 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.377N P=0.195N P=0.532N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.377N P=0.195N P=0.532N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.377N P=0.195N P=0.532N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.360N | (e) |
|FISHER EXACT | P=0.247N P=0.500N | (e) (e) |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05038 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIMETHOXANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 62.5 MG/ 125 MG/ | 0 MG/KG 125 MG/ 250 MG/ |
| | KG KG | KG KG |
|=================================================================================================================================|
| |
|Mammary Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 2/50 (4%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 6.7% 0.0% 3.0% |
|TERMINAL (d) | 0/23 (0%) 0/28 (0%) 0/21 (0%) | 2/30 (7%) 0/31 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 730 (T) --- 604 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.412N P=0.231N P=0.571N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.415N P=0.231N P=0.565N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.383N P=0.231N P=0.539N |
|COCHRAN-ARMITAGE | (e) | P=0.360N |
|FISHER EXACT | (e) (e) | P=0.247N P=0.500N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 2/50 (4%) | 14/50 (28%) 11/50 (22%) 13/50 (26%) |
|ADJUSTED (b) | 4.3% 3.2% 4.7% | 38.9% 29.5% 45.6% |
|TERMINAL (d) | 1/23 (4%) 0/28 (0%) 0/21 (0%) | 9/30 (30%) 6/31 (19%) 9/24 (38%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 722 493 | 449 533 607 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.342 P=0.718N P=0.470 | P=0.406 P=0.286N P=0.422 |
|INCIDENTAL TUMOR | P=0.391 P=0.736 P=0.599 | P=0.524 P=0.283N P=0.537 |
|LOGISTIC REGRESSION | P=0.406 P=0.741N P=0.569 | P=0.507 P=0.291N P=0.520 |
|COCHRAN-ARMITAGE | P=0.378 | P=0.454N |
|FISHER EXACT | P=0.753N P=0.500 | P=0.322N P=0.500N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05038 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIMETHOXANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 62.5 MG/ 125 MG/ | 0 MG/KG 125 MG/ 250 MG/ |
| | KG KG | KG KG |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 2/50 (4%) | 16/50 (32%) 11/50 (22%) 14/50 (28%) |
|ADJUSTED (b) | 4.3% 3.2% 4.7% | 44.7% 29.5% 47.3% |
|TERMINAL (d) | 1/23 (4%) 0/28 (0%) 0/21 (0%) | 11/30 (37%) 6/31 (19%) 9/24 (38%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 722 493 | 449 533 604 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.342 P=0.718N P=0.470 | P=0.478 P=0.163N P=0.483 |
|INCIDENTAL TUMOR | P=0.391 P=0.736 P=0.599 | P=0.494N P=0.153N P=0.578N |
|LOGISTIC REGRESSION | P=0.406 P=0.741N P=0.569 | P=0.502N P=0.155N P=0.586N |
|COCHRAN-ARMITAGE | P=0.378 | P=0.368N |
|FISHER EXACT | P=0.753N P=0.500 | P=0.184N P=0.414N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 2/50 (4%) | 16/50 (32%) 11/50 (22%) 14/50 (28%) |
|ADJUSTED (b) | 4.3% 3.2% 4.7% | 44.7% 29.5% 47.3% |
|TERMINAL (d) | 1/23 (4%) 0/28 (0%) 0/21 (0%) | 11/30 (37%) 6/31 (19%) 9/24 (38%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 722 493 | 449 533 604 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.342 P=0.718N P=0.470 | P=0.478 P=0.163N P=0.483 |
|INCIDENTAL TUMOR | P=0.391 P=0.736 P=0.599 | P=0.494N P=0.153N P=0.578N |
|LOGISTIC REGRESSION | P=0.406 P=0.741N P=0.569 | P=0.502N P=0.155N P=0.586N |
|COCHRAN-ARMITAGE | P=0.378 | P=0.368N |
|FISHER EXACT | P=0.753N P=0.500 | P=0.184N P=0.414N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05038 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIMETHOXANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 62.5 MG/ 125 MG/ | 0 MG/KG 125 MG/ 250 MG/ |
| | KG KG | KG KG |
|=================================================================================================================================|
| |
|Parathyroid Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 0/46 (0%) 0/47 (0%) | 0/46 (0%) 0/43 (0%) 0/42 (0%) |
|ADJUSTED (b) | 8.1% 0.0% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/22 (5%) 0/26 (0%) 0/18 (0%) | 0/27 (0%) 0/26 (0%) 0/20 (0%) |
|FIRST INCIDENCE (DAYS) | 718 --- --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.107N P=0.207N P=0.291N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.150N P=0.279N P=0.356N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.119N P=0.225N P=0.317N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.101N | (e) |
|FISHER EXACT | P=0.263N P=0.258N | (e) (e) |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 13/49 (27%) 7/50 (14%) 11/49 (22%) | 13/48 (27%) 13/49 (27%) 7/50 (14%) |
|ADJUSTED (b) | 35.7% 21.5% 36.0% | 36.2% 38.6% 23.6% |
|TERMINAL (d) | 3/23 (13%) 4/28 (14%) 5/21 (24%) | 8/30 (27%) 10/30 (33%) 3/24 (13%) |
|FIRST INCIDENCE (DAYS) | 349 674 371 | 580 599 567 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.494N P=0.080N P=0.561N | P=0.221N P=0.560N P=0.249N |
|INCIDENTAL TUMOR | P=0.453N P=0.174N P=0.461N | P=0.161N P=0.493 P=0.163N |
|LOGISTIC REGRESSION | P=0.356N P=0.097N P=0.363N | P=0.144N P=0.549N P=0.151N |
|COCHRAN-ARMITAGE | P=0.355N | P=0.075N |
|FISHER EXACT | P=0.096N P=0.407N | P=0.566N P=0.087N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05038 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIMETHOXANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 62.5 MG/ 125 MG/ | 0 MG/KG 125 MG/ 250 MG/ |
| | KG KG | KG KG |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.8% 10.3% 7.3% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/23 (0%) 2/28 (7%) 0/21 (0%) | 0/30 (0%) 0/31 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 656 724 598 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.326 P=0.355 P=0.409 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.286 P=0.261 P=0.390 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.359 P=0.311 P=0.508 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.399 | (e) |
|FISHER EXACT | P=0.309 P=0.500 | (e) (e) |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 4.3% 5.7% 0.0% | 0.0% 2.3% 0.0% |
|TERMINAL (d) | 1/23 (4%) 0/28 (0%) 0/21 (0%) | 0/30 (0%) 0/31 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 674 --- | --- 541 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.408N P=0.554 P=0.518N | P=0.716 P=0.500 (e) |
|INCIDENTAL TUMOR | P=0.524N P=0.420 P=0.518N | P=0.669N P=0.612 (e) |
|LOGISTIC REGRESSION | P=0.396N P=0.500 P=0.518N | P=0.697N P=0.473 (e) |
|COCHRAN-ARMITAGE | P=0.360N | P=0.731 |
|FISHER EXACT | P=0.500 P=0.500N | P=0.500 (e) |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05038 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIMETHOXANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 62.5 MG/ 125 MG/ | 0 MG/KG 125 MG/ 250 MG/ |
| | KG KG | KG KG |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 5/50 (10%) 2/50 (4%) | 0/50 (0%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 7.0% 15.4% 7.3% | 0.0% 2.3% 3.4% |
|TERMINAL (d) | 1/23 (4%) 2/28 (7%) 0/21 (0%) | 0/30 (0%) 0/31 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 656 674 598 | --- 541 668 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.491 P=0.283 P=0.611 | P=0.301 P=0.500 P=0.468 |
|INCIDENTAL TUMOR | P=0.385 P=0.149 P=0.609 | P=0.397 P=0.612 P=0.536 |
|LOGISTIC REGRESSION | P=0.529 P=0.218 P=0.681 | P=0.354 P=0.473 P=0.487 |
|COCHRAN-ARMITAGE | P=0.583 | P=0.331 |
|FISHER EXACT | P=0.218 P=0.691N | P=0.500 P=0.500 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 1/50 (2%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.5% 3.6% 4.8% | 3.3% 0.0% 0.0% |
|TERMINAL (d) | 0/23 (0%) 1/28 (4%) 1/21 (5%) | 1/30 (3%) 0/31 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 641 730 (T) 730 (T) | 730 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.435N P=0.467N P=0.580N | P=0.294N P=0.493N P=0.545N |
|INCIDENTAL TUMOR | P=0.385N P=0.582N P=0.521N | P=0.294N P=0.493N P=0.545N |
|LOGISTIC REGRESSION | P=0.412N P=0.503N P=0.530N | P=0.294N P=0.493N P=0.545N |
|COCHRAN-ARMITAGE | P=0.378N | P=0.269N |
|FISHER EXACT | P=0.500N P=0.500N | P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05038 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIMETHOXANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 62.5 MG/ 125 MG/ | 0 MG/KG 125 MG/ 250 MG/ |
| | KG KG | KG KG |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 7.1% 7.7% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/23 (0%) 2/28 (7%) 1/21 (5%) | 0/30 (0%) 0/31 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | --- 730 (T) 619 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.145 P=0.282 P=0.209 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.210 P=0.282 P=0.308 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.140 P=0.282 P=0.221 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.176 | (e) |
|FISHER EXACT | P=0.247 P=0.247 | (e) (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 3/50 (6%) 3/50 (6%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 5.5% 10.7% 12.4% | 3.3% 2.1% 0.0% |
|TERMINAL (d) | 0/23 (0%) 3/28 (11%) 2/21 (10%) | 1/30 (3%) 0/31 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 641 730 (T) 619 | 730 (T) 515 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.341 P=0.561 P=0.412 | P=0.355N P=0.750N P=0.545N |
|INCIDENTAL TUMOR | P=0.444 P=0.472 P=0.543 | P=0.294N P=0.696N P=0.545N |
|LOGISTIC REGRESSION | P=0.350 P=0.500 P=0.465 | P=0.317N P=0.752 P=0.545N |
|COCHRAN-ARMITAGE | P=0.412 | P=0.331N |
|FISHER EXACT | P=0.500 P=0.500 | P=0.753N P=0.500N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05038 TEST: 01 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIMETHOXANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 62.5 MG/ 125 MG/ | 0 MG/KG 125 MG/ 250 MG/ |
| | KG KG | KG KG |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 2/50 (4%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 7.1% 7.7% | 0.0% 2.1% 0.0% |
|TERMINAL (d) | 0/23 (0%) 2/28 (7%) 1/21 (5%) | 0/30 (0%) 0/31 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | --- 730 (T) 619 | --- 515 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.145 P=0.282 P=0.209 | P=0.730 P=0.513 (e) |
|INCIDENTAL TUMOR | P=0.210 P=0.282 P=0.308 | P=0.669N P=0.612 (e) |
|LOGISTIC REGRESSION | P=0.140 P=0.282 P=0.221 | P=0.689N P=0.468 (e) |
|COCHRAN-ARMITAGE | P=0.176 | P=0.731 |
|FISHER EXACT | P=0.247 P=0.247 | P=0.500 (e) |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 45/50 (90%) 43/50 (86%) 44/50 (88%) | |
|ADJUSTED (b) | 97.8% 97.7% 100.0% | |
|TERMINAL (d) | 22/23 (96%) 27/28 (96%) 21/21 (100%) | |
|FIRST INCIDENCE (DAYS) | 450 514 493 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.254 P=0.152N P=0.256 | |
|INCIDENTAL TUMOR | P=0.533 P=0.415N P=0.563 | |
|LOGISTIC REGRESSION | P=0.402 P=0.578N P=0.501 | |
|COCHRAN-ARMITAGE | P=0.439N | |
|FISHER EXACT | P=0.380N P=0.500N | |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05038 TEST: 01 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIMETHOXANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 62.5 MG/ 125 MG/ | 0 MG/KG 125 MG/ 250 MG/ |
| | KG KG | KG KG |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 13/50 (26%) 12/50 (24%) 10/50 (20%) | 13/50 (26%) 12/50 (24%) 7/50 (14%) |
|ADJUSTED (b) | 41.9% 34.4% 36.1% | 39.0% 38.7% 25.2% |
|TERMINAL (d) | 7/23 (30%) 6/28 (21%) 6/21 (29%) | 10/30 (33%) 12/31 (39%) 4/24 (17%) |
|FIRST INCIDENCE (DAYS) | 593 619 423 | 634 730 (T) 607 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.426N P=0.360N P=0.472N | P=0.199N P=0.451N P=0.240N |
|INCIDENTAL TUMOR | P=0.371N P=0.559 P=0.337N | P=0.165N P=0.469N P=0.171N |
|LOGISTIC REGRESSION | P=0.376N P=0.500N P=0.406N | P=0.168N P=0.393N P=0.192N |
|COCHRAN-ARMITAGE | P=0.277N | P=0.090N |
|FISHER EXACT | P=0.500N P=0.318N | P=0.500N P=0.105N |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 0/50 (0%) | 2/50 (4%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 8.7% 6.7% 0.0% | 6.7% 2.3% 3.0% |
|TERMINAL (d) | 2/23 (9%) 1/28 (4%) 0/21 (0%) | 2/30 (7%) 0/31 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 722 --- | 730 (T) 541 604 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.190N P=0.624N P=0.257N | P=0.434N P=0.492N P=0.571N |
|INCIDENTAL TUMOR | P=0.230N P=0.682N P=0.257N | P=0.386N P=0.429N P=0.565N |
|LOGISTIC REGRESSION | P=0.214N P=0.654N P=0.257N | P=0.377N P=0.501N P=0.539N |
|COCHRAN-ARMITAGE | P=0.176N | P=0.378N |
|FISHER EXACT | P=0.691N P=0.247N | P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05038 TEST: 01 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIMETHOXANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 62.5 MG/ 125 MG/ | 0 MG/KG 125 MG/ 250 MG/ |
| | KG KG | KG KG |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/50 (28%) 14/50 (28%) 10/50 (20%) | 15/50 (30%) 13/50 (26%) 8/50 (16%) |
|ADJUSTED (b) | 45.5% 39.4% 36.1% | 45.1% 40.1% 27.4% |
|TERMINAL (d) | 8/23 (35%) 7/28 (25%) 6/21 (29%) | 12/30 (40%) 12/31 (39%) 4/24 (17%) |
|FIRST INCIDENCE (DAYS) | 593 619 423 | 634 541 604 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.352N P=0.422N P=0.387N | P=0.162N P=0.361N P=0.203N |
|INCIDENTAL TUMOR | P=0.315N P=0.464 P=0.259N | P=0.123N P=0.351N P=0.140N |
|LOGISTIC REGRESSION | P=0.312N P=0.587N P=0.329N | P=0.121N P=0.320N P=0.149N |
|COCHRAN-ARMITAGE | P=0.210N | P=0.064N |
|FISHER EXACT | P=0.588N P=0.241N | P=0.412N P=0.077N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 3/50 (6%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 9.2% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/23 (0%) 1/28 (4%) 0/21 (0%) | 0/30 (0%) 0/31 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | --- 694 --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.591 P=0.150 (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.476 P=0.082 (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.597 P=0.122 (e) | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.640 | (e) |
|FISHER EXACT | P=0.121 (e) | (e) (e) |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05038 TEST: 01 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIMETHOXANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 62.5 MG/ 125 MG/ | 0 MG/KG 125 MG/ 250 MG/ |
| | KG KG | KG KG |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 4/50 (8%) 1/50 (2%) | 1/50 (2%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 12.6% 4.8% | 3.3% 0.0% 3.1% |
|TERMINAL (d) | 0/23 (0%) 2/28 (7%) 1/21 (5%) | 1/30 (3%) 0/31 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | --- 694 730 (T) | 730 (T) --- 607 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.333 P=0.087 P=0.482 | P=0.628 P=0.493N P=0.713 |
|INCIDENTAL TUMOR | P=0.255 P=0.047 * P=0.482 | P=0.623 P=0.493N P=0.722 |
|LOGISTIC REGRESSION | P=0.314 P=0.065 P=0.482 | P=0.662 P=0.493N P=0.750 |
|COCHRAN-ARMITAGE | P=0.390 | P=0.669N |
|FISHER EXACT | P=0.059 P=0.500 | P=0.500N P=0.753N |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 6/50 (12%) 3/50 (6%) 2/50 (4%) |
|ADJUSTED (b) | | 17.4% 8.6% 4.6% |
|TERMINAL (d) | | 4/30 (13%) 2/31 (6%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | | 562 544 515 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.135N P=0.238N P=0.202N |
|INCIDENTAL TUMOR | | P=0.090N P=0.312N P=0.134N |
|LOGISTIC REGRESSION | | P=0.086N P=0.239N P=0.132N |
|COCHRAN-ARMITAGE | | P=0.090N |
|FISHER EXACT | | P=0.243N P=0.134N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05038 TEST: 01 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIMETHOXANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 62.5 MG/ 125 MG/ | 0 MG/KG 125 MG/ 250 MG/ |
| | KG KG | KG KG |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | | 0.0% 4.7% 0.0% |
|TERMINAL (d) | | 0/30 (0%) 0/31 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | | --- 526 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.641 P=0.259 (e) |
|INCIDENTAL TUMOR | | P=0.603N P=0.358 (e) |
|LOGISTIC REGRESSION | | P=0.645N P=0.220 (e) |
|COCHRAN-ARMITAGE | | P=0.669 |
|FISHER EXACT | | P=0.247 (e) |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 6/50 (12%) 5/50 (10%) 2/50 (4%) |
|ADJUSTED (b) | | 17.4% 12.9% 4.6% |
|TERMINAL (d) | | 4/30 (13%) 2/31 (6%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | | 562 526 515 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.163N P=0.480N P=0.202N |
|INCIDENTAL TUMOR | | P=0.091N P=0.516N P=0.134N |
|LOGISTIC REGRESSION | | P=0.098N P=0.507N P=0.132N |
|COCHRAN-ARMITAGE | | P=0.107N |
|FISHER EXACT | | P=0.500N P=0.134N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05038 TEST: 01 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIMETHOXANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 62.5 MG/ 125 MG/ | 0 MG/KG 125 MG/ 250 MG/ |
| | KG KG | KG KG |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, |
| or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 19/50 (38%) 14/50 (28%) 9/50 (18%) | 12/50 (24%) 14/50 (28%) 12/50 (24%) |
|ADJUSTED (b) | 47.4% 39.7% 33.4% | 31.4% 36.5% 38.5% |
|TERMINAL (d) | 4/23 (17%) 8/28 (29%) 5/21 (24%) | 6/30 (20%) 7/31 (23%) 6/24 (25%) |
|FIRST INCIDENCE (DAYS) | 507 563 423 | 485 544 523 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.070N P=0.155N P=0.107N | P=0.342 P=0.480 P=0.394 |
|INCIDENTAL TUMOR | P=0.032N* P=0.410N P=0.058N | P=0.530 P=0.584 P=0.582 |
|LOGISTIC REGRESSION | P=0.024N* P=0.390N P=0.028N* | P=0.452 P=0.434 P=0.519 |
|COCHRAN-ARMITAGE | P=0.017N* | P=0.546N |
|FISHER EXACT | P=0.198N P=0.022N* | P=0.410 P=0.592N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 3.2% 6.4% |
|TERMINAL (d) | 0/23 (0%) 0/28 (0%) 0/21 (0%) | 0/30 (0%) 1/31 (3%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | --- 730 (T) 604 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.111 P=0.507 P=0.205 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.137 P=0.507 P=0.246 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.133 P=0.507 P=0.236 |
|COCHRAN-ARMITAGE | (e) | P=0.142 |
|FISHER EXACT | (e) (e) | P=0.500 P=0.247 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05038 TEST: 01 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIMETHOXANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 62.5 MG/ 125 MG/ | 0 MG/KG 125 MG/ 250 MG/ |
| | KG KG | KG KG |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.7% 3.2% 3.3% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/23 (0%) 0/28 (0%) 0/21 (0%) | 0/30 (0%) 0/31 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 652 722 634 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.460N P=0.467N P=0.602N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.507N P=0.657N P=0.610N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.387N P=0.503N P=0.494N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.378N | (e) |
|FISHER EXACT | P=0.500N P=0.500N | (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 50/50 (100%) 45/50 (90%) 48/50 (96%) | 35/50 (70%) 28/50 (56%) 26/50 (52%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | 81.3% 71.2% 71.4% |
|TERMINAL (d) | 23/23 (100%) 28/28 (100%) 21/21 (100%) | 22/30 (73%) 20/31 (65%) 14/24 (58%) |
|FIRST INCIDENCE (DAYS) | 349 514 371 | 449 533 388 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.290 P=0.069N P=0.291 | P=0.319N P=0.105N P=0.385N |
|INCIDENTAL TUMOR | P=0.298N P=0.062N P=0.320N | P=0.109N P=0.129N P=0.114N |
|LOGISTIC REGRESSION | P=0.389N P=0.059N P=0.384N | P=0.103N P=0.062N P=0.122N |
|COCHRAN-ARMITAGE | P=0.238N | P=0.042N* |
|FISHER EXACT | P=0.028N* P=0.247N | P=0.107N P=0.050N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05038 TEST: 01 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIMETHOXANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 62.5 MG/ 125 MG/ | 0 MG/KG 125 MG/ 250 MG/ |
| | KG KG | KG KG |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 24/50 (48%) 24/50 (48%) 16/50 (32%) | 14/50 (28%) 20/50 (40%) 16/50 (32%) |
|ADJUSTED (b) | 58.2% 58.9% 54.9% | 37.1% 46.9% 46.4% |
|TERMINAL (d) | 7/23 (30%) 12/28 (43%) 9/21 (43%) | 8/30 (27%) 9/31 (29%) 6/24 (25%) |
|FIRST INCIDENCE (DAYS) | 507 380 423 | 485 515 523 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.231N P=0.405N P=0.283N | P=0.195 P=0.227 P=0.228 |
|INCIDENTAL TUMOR | P=0.127N P=0.368 P=0.163N | P=0.371 P=0.324 P=0.382 |
|LOGISTIC REGRESSION | P=0.090N P=0.418 P=0.117N | P=0.301 P=0.153 P=0.330 |
|COCHRAN-ARMITAGE | P=0.065N | P=0.375 |
|FISHER EXACT | P=0.579N P=0.076N | P=0.146 P=0.414 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 50/50 (100%) 47/50 (94%) 48/50 (96%) | 41/50 (82%) 37/50 (74%) 32/50 (64%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | 89.0% 80.3% 81.7% |
|TERMINAL (d) | 23/23 (100%) 28/28 (100%) 21/21 (100%) | 25/30 (83%) 22/31 (71%) 17/24 (71%) |
|FIRST INCIDENCE (DAYS) | 349 380 371 | 449 515 388 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.292 P=0.126N P=0.291 | P=0.401N P=0.229N P=0.452N |
|INCIDENTAL TUMOR | P=0.246N P=0.187N P=0.320N | P=0.059N P=0.150N P=0.080N |
|LOGISTIC REGRESSION | P=0.314N P=0.301N P=0.384N | P=0.073N P=0.174N P=0.092N |
|COCHRAN-ARMITAGE | P=0.202N | P=0.027N* |
|FISHER EXACT | P=0.121N P=0.247N | P=0.235N P=0.035N* |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05038 TEST: 01 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIMETHOXANE
TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
--multipart-boundary
Content-type: text/plain
Range: bytes 128097-128097/128097
--multipart-boundary--