TR 354 Rat Pathology Tables
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
Facility: Battelle Columbus Laboratory
Chemical CAS #: 828-00-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7|
DAY ON TEST | 6| 3| 2| 8| 4| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 8| 9| 3| 3|
| 2| 0| 3| 3| 9| 0| 0| 4| 0| 0| 5| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 5| 8| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 |
Hemorrhage, Acute | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + M + + + + + + + I + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Chronic | 1 2 2 2 1 2 2 2 1 3 2 2 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
Mineralization | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 2 2 2 2 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Acinus, Atrophy | 2 |
Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7|
DAY ON TEST | 6| 3| 2| 8| 4| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 8| 9| 3| 3|
| 2| 0| 3| 3| 9| 0| 0| 4| 0| 0| 5| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 5| 8| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Degeneration, Fatty | 2 |
Hyperplasia | 2 2 2 2 2 2 2 |
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + I + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Pars Distalis, Cyst | X X X X X X X X |
Pars Distalis, Hemorrhage, Acute | |
Pars Distalis, Hyperplasia | 3 2 2 2 2 3 2 2 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 |
Hemorrhage | |
Prolapse | X |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 |
__________________________________________________________________________|
Vagina | + + |
Prolapse | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Reticulum Cell | 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Cyst | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + I + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + M + + + M M + + M + + + M +|
Cyst | X |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7|
DAY ON TEST | 6| 3| 2| 8| 4| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 8| 9| 3| 3|
| 2| 0| 3| 3| 9| 0| 0| 4| 0| 0| 5| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 5| 8| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 4 4 2 2 3 3 4 3 3 3 3 2 2 4 3 3 2 2 2 2 3 1 3 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
Hemorrhage, Acute | |
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Inflammation, Chronic | 2 1 2 2 1 1 1 2|
Alveolar Epithelium, Hyperplasia | 1 1 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Hemorrhage, Acute | |
Lens, Cataract | 4 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Infarct, Chronic | |
Mineralization | 1 1 |
Nephropathy, Chronic | 1 1 1 2 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1 2 |
__________________________________________________________________________|
Ureter | + + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + A + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 6| 5| 5| 7| 7| 7| 7| 7| 6| 0| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 4| 5|
DAY ON TEST | 4| 7| 8| 3| 3| 3| 3| 3| 4| 8| 2| 3| 3| 3| 3| 9| 9| 3| 3| 3| 3| 3| 1| 6| 8|
| 6| 1| 0| 1| 1| 1| 1| 2| 2| 5| 5| 2| 2| 2| 2| 3| 8| 2| 2| 2| 2| 2| 5| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Hemorrhage, Acute | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + A + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + A + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Chronic | 2 2 2 1 1 2 1 2 1 2 1 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
Mineralization | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 2 1 3 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + M + M + + + + + + +|
Inflammation, Chronic Active | |
Acinus, Atrophy | |
Duct, Hyperplasia | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 1 2 1 2 2 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 6| 5| 5| 7| 7| 7| 7| 7| 6| 0| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 4| 5|
DAY ON TEST | 4| 7| 8| 3| 3| 3| 3| 3| 4| 8| 2| 3| 3| 3| 3| 9| 9| 3| 3| 3| 3| 3| 1| 6| 8|
| 6| 1| 0| 1| 1| 1| 1| 2| 2| 5| 5| 2| 2| 2| 2| 3| 8| 2| 2| 2| 2| 2| 5| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Degeneration, Fatty | 2 2 |
Hyperplasia | 2 2 2 2 1 2 2 2 2 2 |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + I + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X X X X X X X X|
Pars Distalis, Hemorrhage, Acute | 4 |
Pars Distalis, Hyperplasia | 2 2 3 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + M + + + + + + + + M + +|
Hyperplasia | 2 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3|
Hemorrhage | 4 3|
Prolapse | |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 1 |
__________________________________________________________________________|
Vagina | |
Prolapse | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Reticulum Cell | 1 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Cyst | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + M + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + M + + M + + + + + + + + M + + + + + + +|
Cyst | X X |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 6| 5| 5| 7| 7| 7| 7| 7| 6| 0| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 4| 5|
DAY ON TEST | 4| 7| 8| 3| 3| 3| 3| 3| 4| 8| 2| 3| 3| 3| 3| 9| 9| 3| 3| 3| 3| 3| 1| 6| 8|
| 6| 1| 0| 1| 1| 1| 1| 2| 2| 5| 5| 2| 2| 2| 2| 3| 8| 2| 2| 2| 2| 2| 5| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + M|
Hyperplasia, Cystic | 2 3 2 2 2 3 2 2 3 2 4 2 3 2 3 4 2 3 1 3 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X |
Hemorrhage, Acute | 4 4 4 |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Inflammation, Chronic | 3 1 1 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Inflammation, Chronic Active | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Hemorrhage, Acute | 3 |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infarct, Chronic | 3 |
Mineralization | 1 |
Nephropathy, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Ureter | + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 50 |
Foreign Body | | 1 3.0|
Hemorrhage, Acute | 3 | 1 3.0|
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large | + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A | 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 48 |
Diverticulum | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 47 |
Parasite Metazoan | | 4 |
__________________________________________________________________________|____________|
Intestine Small | + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A | 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 47 |
__________________________________________________________________________|____________|
Liver | + | 50 |
Basophilic Focus | | 40 |
Clear Cell Focus | | 3 |
Hepatodiaphragmatic Nodule | | 6 |
Inflammation, Chronic | | 23 1.7|
Necrosis, Coagulative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 47 |
Inflammation, Chronic Active | | 2 4.0|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + | 50 |
Acinus, Atrophy | | 14 1.7|
__________________________________________________________________________|____________|
Salivary Glands | + | 48 |
Inflammation, Chronic Active | | 1 2.0|
Acinus, Atrophy | | 1 2.0|
Duct, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 50 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 50 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + | 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 49 |
__________________________________________________________________________|____________|
Heart | + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy, Chronic | 2 | 37 1.9|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + | 50 |
Degeneration, Fatty | | 3 2.0|
Hyperplasia | | 17 1.9|
Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + | 50 |
Hyperplasia | | 5 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + | 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + | 48 |
Pars Distalis, Cyst | X | 19 |
Pars Distalis, Hemorrhage, Acute | | 1 4.0|
Pars Distalis, Hyperplasia | | 20 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + | 50 |
C-Cell, Hyperplasia | | 26 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 47 |
Hyperplasia | | 5 2.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + | 50 |
Cyst | | 3 |
__________________________________________________________________________|____________|
Oviduct | + | 50 |
__________________________________________________________________________|____________|
Uterus | + | 50 |
Dilatation | 3 | 5 3.0|
Hemorrhage | | 2 3.5|
Prolapse | | 1 |
Endometrium, Hyperplasia, Cystic, | | |
Glandular | | 2 1.5|
__________________________________________________________________________|____________|
Vagina | | 2 |
Prolapse | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 50 |
Femoral, Hyperplasia, Reticulum Cell | | 5 1.8|
__________________________________________________________________________|____________|
Lymph Node | + | 50 |
Inguinal, Cyst | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 47 |
__________________________________________________________________________|____________|
Spleen | + | 50 |
Fibrosis | | 1 3.0|
Hematopoietic Cell Proliferation | 3 | 3 3.0|
__________________________________________________________________________|____________|
Thymus | + | 41 |
Cyst | | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M | 47 |
Hyperplasia, Cystic | | 47 2.6|
__________________________________________________________________________|____________|
Skin | + | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 50 |
Compression | | 5 |
Hemorrhage, Acute | | 3 4.0|
Hydrocephalus | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 50 |
Foreign Body | | 2 2.0|
Inflammation, Chronic | 2 | 12 1.6|
Alveolar Epithelium, Hyperplasia | | 3 1.3|
__________________________________________________________________________|____________|
Nose | + | 50 |
Foreign Body | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Hemorrhage, Acute | | 1 3.0|
Lens, Cataract | | 1 4.0|
Retina, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | M | 49 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 50 |
Cyst | | 1 |
Infarct, Chronic | | 1 3.0|
Mineralization | | 3 1.0|
Nephropathy, Chronic | | 38 1.1|
__________________________________________________________________________|____________|
Ureter | + | 12 |
__________________________________________________________________________|____________|
Urinary Bladder | + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 5| 7| 7| 7| 7| 5| 1|
DAY ON TEST | 0| 3| 3| 3| 3| 1| 3| 3| 3| 0| 3| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3| 2| 3| 4| 2|
| 7| 0| 0| 0| 0| 5| 0| 0| 0| 9| 0| 0| 0| 0| 1| 9| 1| 3| 6| 1| 1| 6| 1| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
125 MG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + M + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X |
Clear Cell Focus | |
Degeneration, Cystic | |
Inflammation, Chronic | 2 2 2 2 2 2 2 |
Vacuolization Cytoplasmic | 4 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 2 1 1 1 1 1 1 2 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | 1 1 2 2 |
Hyperkeratosis, Focal | 1 2 1 |
Hyperplasia, Focal | 2 |
Inflammation, Chronic Active | 1 3 |
Ulcer | 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium, Multiple | |
Cardiomyopathy, Chronic | 1 2 2 1 1 2 2 1 2 2 2 2 1 2 1 2 |
Foreign Body | |
Infarct | 1 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 5| 7| 7| 7| 7| 5| 1|
DAY ON TEST | 0| 3| 3| 3| 3| 1| 3| 3| 3| 0| 3| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3| 2| 3| 4| 2|
| 7| 0| 0| 0| 0| 5| 0| 0| 0| 9| 0| 0| 0| 0| 1| 9| 1| 3| 6| 1| 1| 6| 1| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
125 MG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 3 1 |
Hyperplasia | 2 2 2 2 2 2 2 2 1 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + I + M + + + + M + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X X X X X X X X X X X X |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 3 2 |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 1 2 2 2 2 2 2 2 2 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + M M + + + + +|
Hyperplasia | 2 3 |
Inflammation, Chronic Active | 4 |
Necrosis, Caseous | |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + M + + + + + + + + + + + +|
Atrophy | 2 |
Cyst | X X |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + M + + + + + + + + + + + +|
Dilatation | |
Hemorrhage | 3 |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Reticulum Cell | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Inflammation, Chronic | |
Active | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 5| 7| 7| 7| 7| 5| 1|
DAY ON TEST | 0| 3| 3| 3| 3| 1| 3| 3| 3| 0| 3| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3| 2| 3| 4| 2|
| 7| 0| 0| 0| 0| 5| 0| 0| 0| 9| 0| 0| 0| 0| 1| 9| 1| 3| 6| 1| 1| 6| 1| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
125 MG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Thrombosis | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 |
Infarct, Chronic | |
__________________________________________________________________________|
Thymus | + M M + + M + + + + + M M + + + + + + + + M + + +|
Necrosis | 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Hyperplasia, Cystic | 2 2 2 3 2 1 2 2 3 3 2 4 2 4 2 3 3 2 3 2 2 2 3 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X |
Hemorrhage, Acute | 2 |
Hydrocephalus | 3 2 3 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2|
Inflammation, Chronic | 2 2 2 1 1 2 1 |
Mediastinum, Bacterium, Multiple | |
Mediastinum, Inflammation, Chronic | |
Active | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 2 |
Inflammation, Chronic Active | 1 2 4 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 3 |
Retina, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 5| 7| 7| 7| 7| 5| 1|
DAY ON TEST | 0| 3| 3| 3| 3| 1| 3| 3| 3| 0| 3| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3| 2| 3| 4| 2|
| 7| 0| 0| 0| 0| 5| 0| 0| 0| 9| 0| 0| 0| 0| 1| 9| 1| 3| 6| 1| 1| 6| 1| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
125 MG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Nephropathy, Chronic | 1 1 1 1 1 1 1 1 2 3 2 1 1 1 3 1 1 |
__________________________________________________________________________|
Ureter | + + + + + + + + +|
__________________________________________________________________________|
Urethra | + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 3| 5| 3| 3| 3| 3| 3| 3| 3| 7| 7| 4| 3| 3| 3| 0| 2| 3| 2| 1| 3| 3| 3|
| 1| 5| 1| 9| 1| 1| 1| 2| 2| 2| 2| 7| 0| 4| 8| 2| 2| 6| 6| 2| 6| 4| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
125 MG/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + A + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + A + + M + + + + + + + + + + + + + + + + + + M +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X |
Degeneration, Cystic | 2 |
Inflammation, Chronic | 2 1 2 2 1 2 2 2 2 2 2 |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 2 1 3 2 1|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | 1 1 1 1 |
Hyperkeratosis, Focal | 1 1 |
Hyperplasia, Focal | |
Inflammation, Chronic Active | 2 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium, Multiple | X |
Cardiomyopathy, Chronic | 2 2 2 1 2 2 1 2 2 1 1 2 2 2 3 2 1|
Foreign Body | 4 |
Infarct | |
Inflammation, Chronic Active | 4 4 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 3| 5| 3| 3| 3| 3| 3| 3| 3| 7| 7| 4| 3| 3| 3| 0| 2| 3| 2| 1| 3| 3| 3|
| 1| 5| 1| 9| 1| 1| 1| 2| 2| 2| 2| 7| 0| 4| 8| 2| 2| 6| 6| 2| 6| 4| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
125 MG/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 2 2 2 3 2 2 3 2 2 |
Hyperplasia | 2 2 2 2 2 2 2 2 2 3 2 |
Necrosis, Coagulative | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + M + + + M M + + + + + + + + +|
Cyst | X |
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + I + + + + + + + + +|
Pars Distalis, Cyst | X X X X X X X |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 3 3 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + M + + + + + + + + + M + + + + + +|
Hyperplasia | 2 4 2 1 2 |
Inflammation, Chronic Active | 2 2 |
Necrosis, Caseous | 3 1 |
Duct, Dilatation | 4 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
Cyst | X X |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 2 4 2 3 |
Hemorrhage | |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Inflammation, Chronic | |
Active | 3 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 3| 5| 3| 3| 3| 3| 3| 3| 3| 7| 7| 4| 3| 3| 3| 0| 2| 3| 2| 1| 3| 3| 3|
| 1| 5| 1| 9| 1| 1| 1| 2| 2| 2| 2| 7| 0| 4| 8| 2| 2| 6| 6| 2| 6| 4| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
125 MG/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Thrombosis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Infarct, Chronic | 4 |
__________________________________________________________________________|
Thymus | + M + + + + M + + + + + M M + + + + + + + M + M +|
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Cystic | 2 2 2 2 2 2 1 4 2 2 3 2 3 2 2 2 4 2 4 2 2 2 3 2 4|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X |
Hemorrhage, Acute | 3 |
Hydrocephalus | 2 2 2 2 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 3 |
Inflammation, Chronic | 2 3 3 1 |
Mediastinum, Bacterium, Multiple | X |
Mediastinum, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 1 2 |
Inflammation, Chronic Active | 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 4 |
Retina, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 3| 5| 3| 3| 3| 3| 3| 3| 3| 7| 7| 4| 3| 3| 3| 0| 2| 3| 2| 1| 3| 3| 3|
| 1| 5| 1| 9| 1| 1| 1| 2| 2| 2| 2| 7| 0| 4| 8| 2| 2| 6| 6| 2| 6| 4| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
125 MG/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Harderian Gland | + + + I + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
Nephropathy, Chronic | 1 1 1 1 1 1 2 2 1 1 1 3 2 1 1 1 1 1|
__________________________________________________________________________|
Ureter | + + + + + + + + |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
125 MG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 47 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 47 |
Parasite Metazoan | | 4 |
__________________________________________________________________________|____________|
Intestine Small | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 49 |
__________________________________________________________________________|____________|
Liver | | 49 |
Basophilic Focus | | 35 |
Clear Cell Focus | | 3 |
Degeneration, Cystic | | 1 2.0|
Inflammation, Chronic | | 18 1.9|
Vacuolization Cytoplasmic | | 2 3.5|
__________________________________________________________________________|____________|
Mesentery | | 46 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Acinus, Atrophy | | 19 1.5|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Acanthosis, Focal | | 8 1.3|
Hyperkeratosis, Focal | | 5 1.2|
Hyperplasia, Focal | | 1 2.0|
Inflammation, Chronic Active | | 3 2.0|
Ulcer | | 3 1.7|
__________________________________________________________________________|____________|
Stomach, Glandular | | 49 |
__________________________________________________________________________|____________|
Tooth | | 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 50 |
__________________________________________________________________________|____________|
Heart | | 50 |
Bacterium, Multiple | | 1 |
Cardiomyopathy, Chronic | | 33 1.7|
Foreign Body | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
125 MG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Infarct | | 1 1.0|
Inflammation, Chronic Active | | 3 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Degeneration, Fatty | | 13 2.2|
Hyperplasia | | 20 2.0|
Necrosis, Coagulative | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Hyperplasia | | 5 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 43 |
Cyst | | 1 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | | 49 |
Pars Distalis, Cyst | | 21 |
Pars Distalis, Hyperplasia | | 18 2.2|
Pars Intermedia, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
C-Cell, Hyperplasia | | 24 1.9|
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 46 |
Hyperplasia | | 7 2.3|
Inflammation, Chronic Active | | 3 2.7|
Necrosis, Caseous | | 2 2.0|
Duct, Dilatation | | 2 3.5|
__________________________________________________________________________|____________|
Ovary | | 49 |
Atrophy | | 3 2.0|
Cyst | | 4 |
__________________________________________________________________________|____________|
Oviduct | | 47 |
__________________________________________________________________________|____________|
Uterus | | 49 |
Dilatation | | 5 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
125 MG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hemorrhage | | 1 3.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | | 6 1.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Femoral, Hyperplasia, Reticulum Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Mediastinal, Inflammation, Chronic | | |
Active | | 1 3.0|
Pancreatic, Thrombosis | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
__________________________________________________________________________|____________|
Spleen | | 50 |
Hematopoietic Cell Proliferation | | 3 3.0|
Infarct, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | | 38 |
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 50 |
Cyst | | 2 |
Hyperplasia, Cystic | | 49 2.4|
__________________________________________________________________________|____________|
Skin | | 50 |
Acanthosis | | 1 2.0|
Hyperkeratosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 49 |
Compression | | 8 |
Hemorrhage, Acute | | 2 2.5|
Hydrocephalus | | 9 2.4|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Foreign Body | | 4 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
125 MG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 11 1.8|
Mediastinum, Bacterium, Multiple | | 1 |
Mediastinum, Inflammation, Chronic | | |
Active | | 1 2.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Foreign Body | | 7 1.9|
Inflammation, Chronic Active | | 5 2.2|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 3 2.3|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Lens, Cataract | | 2 3.5|
Retina, Atrophy | | 2 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 49 |
Atrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Mineralization | | 2 1.5|
Nephropathy, Chronic | | 35 1.3|
__________________________________________________________________________|____________|
Ureter | | 17 |
__________________________________________________________________________|____________|
Urethra | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 0| 6| 7| 7| 5| 7| 7| 7| 5| 6| 5| 5| 7| 7| 7| 5| 5| 6| 5| 6| 7|
DAY ON TEST | 6| 3| 8| 6| 1| 2| 3| 3| 5| 1| 3| 3| 1| 6| 2| 5| 3| 3| 3| 9| 3| 6| 4| 0| 3|
| 8| 0| 7| 7| 5| 5| 0| 0| 4| 5| 0| 0| 5| 8| 3| 7| 0| 0| 0| 7| 8| 8| 7| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
250 MG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | 3 |
Inflammation, Chronic Active | 3 2 |
Perforation | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + A + + + A A + + + +|
Concretion | |
Inflammation, Chronic Active | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + + + + A + + + + A + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + A + + + A A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X|
Clear Cell Focus | X X X|
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic | 2 1 2 1 1 2 1 |
Inflammation, Necrotizing | 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 2 1 1 1|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Diffuse | |
Acanthosis, Focal | 1 1 1 1 1 1 1 2 1 1 2 2 1 2 2 1 1 1 1 3 1 2 1|
Hyperkeratosis, Diffuse | 1 1 2 1 1 2 2 1 |
Hyperkeratosis, Focal | 1 1 2 3 2 |
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 0| 6| 7| 7| 5| 7| 7| 7| 5| 6| 5| 5| 7| 7| 7| 5| 5| 6| 5| 6| 7|
DAY ON TEST | 6| 3| 8| 6| 1| 2| 3| 3| 5| 1| 3| 3| 1| 6| 2| 5| 3| 3| 3| 9| 3| 6| 4| 0| 3|
| 8| 0| 7| 7| 5| 5| 0| 0| 4| 5| 0| 0| 5| 8| 3| 7| 0| 0| 0| 7| 8| 8| 7| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
250 MG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Bacterium, Multiple | |
Cardiomyopathy, Chronic | 3 2 1 2 2 2 2 2 2 2 2 2|
Foreign Body | 3 4 |
Inflammation, Chronic Active | 4 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 2 |
Hyperplasia | 2 2 2 3 2 2 2 2 2|
Hypertrophy | |
Necrosis, Coagulative | 3 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M M + + + M + + + + + + M + + M + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X X X X X X X X X X X X X|
Pars Distalis, Hyperplasia | 1 1 3 2 3 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Chronic | |
Inflammation, Chronic Active | |
C-Cell, Hyperplasia | 2 2 2 2 2 2 2 1 1 2 2 1 2|
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia | 2 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Cyst | X |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2|
Diverticulum | 4 |
Inflammation, Chronic Active | 3 |
Endometrium, Hyperplasia, Cystic, | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 0| 6| 7| 7| 5| 7| 7| 7| 5| 6| 5| 5| 7| 7| 7| 5| 5| 6| 5| 6| 7|
DAY ON TEST | 6| 3| 8| 6| 1| 2| 3| 3| 5| 1| 3| 3| 1| 6| 2| 5| 3| 3| 3| 9| 3| 6| 4| 0| 3|
| 8| 0| 7| 7| 5| 5| 0| 0| 4| 5| 0| 0| 5| 8| 3| 7| 0| 0| 0| 7| 8| 8| 7| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
250 MG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Glandular | 1 3 |
__________________________________________________________________________|
Vagina | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Plasma Cell| |
Mediastinal, Lymphocyte, Necrosis, | |
Acute | 3 |
Mesenteric, Hemorrhage, Acute | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 |
Hyperplasia, Lymphoid | |
Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Thymus | + + M + + + + M + + + M + M + M + + M + + + + + +|
Cyst | X |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + + + + + + M + + + + + +|
Hyperplasia, Cystic | 3 2 3 2 2 3 3 4 3 2 2 2 3 2 2 2 2 2 3 2 2 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X|
Edema | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
Hemorrhage, Acute | 3 |
Hydrocephalus | 3 2 |
Pigmentation, Hemosiderin | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | X |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 0| 6| 7| 7| 5| 7| 7| 7| 5| 6| 5| 5| 7| 7| 7| 5| 5| 6| 5| 6| 7|
DAY ON TEST | 6| 3| 8| 6| 1| 2| 3| 3| 5| 1| 3| 3| 1| 6| 2| 5| 3| 3| 3| 9| 3| 6| 4| 0| 3|
| 8| 0| 7| 7| 5| 5| 0| 0| 4| 5| 0| 0| 5| 8| 3| 7| 0| 0| 0| 7| 8| 8| 7| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
250 MG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Foreign Body | 3 2 |
Inflammation, Chronic | 2 1 2 1 |
Alveolar Epithelium, Hyperplasia | 2 |
Mediastinum, Bacterium, Multiple | |
Mediastinum, Foreign Body | 4 |
Mediastinum, Hemorrhage, Acute | 4 |
Mediastinum, Inflammation, Chronic | |
Active | 3 4 3 |
Pleura, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Hemorrhage, Acute | 3 |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infarct, Chronic | 2|
Mineralization | 1 |
Nephropathy, Chronic | 2 2 1 1 1 1 1 1 1 2 2 1|
__________________________________________________________________________|
Ureter | + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + A + + + + A + + + +|
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 2| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 2|
DAY ON TEST | 3| 3| 3| 4| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 0| 3| 3| 3| 6| 6| 6| 9|
| 1| 1| 1| 4| 6| 1| 1| 1| 1| 2| 2| 2| 8| 8| 2| 2| 6| 7| 2| 2| 2| 5| 5| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
250 MG/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | |
Inflammation, Chronic Active | 3 |
Perforation | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +|
Concretion | 4 |
Inflammation, Chronic Active | 3 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + M + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Chronic | 1 2 1 2 2 1 2 2 2 1 2 2 1 1|
Inflammation, Necrotizing | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 2 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Diffuse | 1 1 |
Acanthosis, Focal | 1 2 1 2 2 1 1 1 1 1 1 1 1 1 2 1 1 |
Hyperkeratosis, Diffuse | 2 |
Hyperkeratosis, Focal | 1 1 1 1 1 2 |
Hyperplasia, Focal | 1 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 2| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 2|
DAY ON TEST | 3| 3| 3| 4| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 0| 3| 3| 3| 6| 6| 6| 9|
| 1| 1| 1| 4| 6| 1| 1| 1| 1| 2| 2| 2| 8| 8| 2| 2| 6| 7| 2| 2| 2| 5| 5| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
250 MG/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Bacterium, Multiple | X |
Cardiomyopathy, Chronic | 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Foreign Body | |
Inflammation, Chronic Active | 4 3 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 2 2 2 2 |
Hyperplasia | 2 1 2 2 2 2 2 2 2 |
Hypertrophy | 2 |
Necrosis, Coagulative | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X X X X X X X X X X X |
Pars Distalis, Hyperplasia | 2 2 2 2 2 3 2 2 3 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Chronic | |
Inflammation, Chronic Active | 3 |
C-Cell, Hyperplasia | 2 2 2 2 2 2 1 1 1 1 2 2 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + + + + + + + + + M + + + + + + +|
Fibrosis | 3 |
Hyperplasia | 2 |
Inflammation, Chronic Active | 1 3 1 2 1 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | X |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Diverticulum | |
Inflammation, Chronic Active | 2 |
Endometrium, Hyperplasia, Cystic, | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 2| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 2|
DAY ON TEST | 3| 3| 3| 4| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 0| 3| 3| 3| 6| 6| 6| 9|
| 1| 1| 1| 4| 6| 1| 1| 1| 1| 2| 2| 2| 8| 8| 2| 2| 6| 7| 2| 2| 2| 5| 5| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
250 MG/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Glandular | 2 1 1 2 2 1 |
__________________________________________________________________________|
Vagina | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Reticulum Cell | 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia, Plasma Cell| 2 |
Mediastinal, Lymphocyte, Necrosis, | |
Acute | |
Mesenteric, Hemorrhage, Acute | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 4 |
Hyperplasia, Reticulum Cell | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M M + M + + + +|
Cyst | X |
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia, Cystic | 3 4 2 2 2 2 3 4 3 3 3 2 2 2 2 2 3 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
Hemorrhage, Acute | 2 |
Hydrocephalus | 3 2 |
Pigmentation, Hemosiderin | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 2| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 2|
DAY ON TEST | 3| 3| 3| 4| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 0| 3| 3| 3| 6| 6| 6| 9|
| 1| 1| 1| 4| 6| 1| 1| 1| 1| 2| 2| 2| 8| 8| 2| 2| 6| 7| 2| 2| 2| 5| 5| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
250 MG/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Foreign Body | 2 3|
Inflammation, Chronic | 4 1 2 1 1 1 |
Alveolar Epithelium, Hyperplasia | 1 |
Mediastinum, Bacterium, Multiple | X |
Mediastinum, Foreign Body | |
Mediastinum, Hemorrhage, Acute | 4 3 |
Mediastinum, Inflammation, Chronic | |
Active | 3 3 2 3 |
Pleura, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Hemorrhage, Acute | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 4 4 |
Retina, Atrophy | 4 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Infarct, Chronic | |
Mineralization | |
Nephropathy, Chronic | 2 1 1 1 1 1 1 2 1 1 1 1 1 3 |
__________________________________________________________________________|
Ureter | + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 2| 4| 4| 4| 3| 2| | |
DAY ON TEST | 6| 6| 6| 6| 0| 6| 6| 6| 8| 5| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
250 MG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 50 |
Hemorrhage, Acute | | 1 3.0|
Inflammation, Chronic Active | | 3 2.7|
Perforation | | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A | 45 |
Concretion | | 1 4.0|
Inflammation, Chronic Active | | 1 3.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 50 |
Parasite Metazoan | | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 46 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A | 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A | 47 |
__________________________________________________________________________|____________|
Liver | + + + | 50 |
Basophilic Focus | | 34 |
Clear Cell Focus | | 3 |
Eosinophilic Focus | | 1 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hepatodiaphragmatic Nodule | | 4 |
Inflammation, Chronic | | 21 1.5|
Inflammation, Necrotizing | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 49 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + | 50 |
Acinus, Atrophy | | 12 1.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + | 49 |
__________________________________________________________________________|____________|
Stomach | + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 50 |
Acanthosis, Diffuse | 1 | 3 1.0|
Acanthosis, Focal | 1 | 41 1.3|
Hyperkeratosis, Diffuse | 1 | 10 1.4|
Hyperkeratosis, Focal | 1 | 12 1.4|
Hyperplasia, Focal | | 3 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 50 |
__________________________________________________________________________|____________|
Tooth | + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 2| 4| 4| 4| 3| 2| | |
DAY ON TEST | 6| 6| 6| 6| 0| 6| 6| 6| 8| 5| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
250 MG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + | 50 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + | 50 |
Bacterium, Multiple | | 1 |
Cardiomyopathy, Chronic | 2 | 32 2.0|
Foreign Body | | 2 3.5|
Inflammation, Chronic Active | 2 | 6 3.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + | 50 |
Degeneration, Fatty | | 7 2.0|
Hyperplasia | | 18 2.0|
Hypertrophy | | 1 2.0|
Necrosis, Coagulative | 2 | 4 2.8|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + | 49 |
Hyperplasia | | 8 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 50 |
Pars Distalis, Cyst | | 28 |
Pars Distalis, Hyperplasia | | 15 2.1|
Pars Distalis, Pigmentation, | | |
Hemosiderin | | 4 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 50 |
Hemorrhage, Chronic | 4 | 1 4.0|
Inflammation, Chronic Active | 4 | 2 3.5|
C-Cell, Hyperplasia | 2 | 27 1.7|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + | 48 |
Fibrosis | | 1 3.0|
Hyperplasia | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 2| 4| 4| 4| 3| 2| | |
DAY ON TEST | 6| 6| 6| 6| 0| 6| 6| 6| 8| 5| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
250 MG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 7 1.7|
__________________________________________________________________________|____________|
Ovary | + + + | 50 |
Atrophy | | 1 2.0|
Cyst | | 2 |
__________________________________________________________________________|____________|
Oviduct | + + | 44 |
__________________________________________________________________________|____________|
Uterus | + + + | 50 |
Dilatation | | 2 2.0|
Diverticulum | | 1 4.0|
Inflammation, Chronic Active | 4 | 3 3.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | | 8 1.6|
__________________________________________________________________________|____________|
Vagina | + | 1 |
Inflammation, Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 50 |
Femoral, Hyperplasia, Reticulum Cell | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + | 50 |
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 2.0|
Mediastinal, Lymphocyte, Necrosis, | | |
Acute | | 1 3.0|
Mesenteric, Hemorrhage, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 49 |
__________________________________________________________________________|____________|
Spleen | + + + | 50 |
Hematopoietic Cell Proliferation | | 4 2.8|
Hyperplasia, Lymphoid | | 1 4.0|
Hyperplasia, Reticulum Cell | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + | 41 |
Cyst | | 2 |
Hyperplasia, Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 47 |
Hyperplasia, Cystic | 2 2 | 43 2.5|
__________________________________________________________________________|____________|
Skin | + + + | 50 |
Cyst Epithelial Inclusion | | 1 |
Edema | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 2| 4| 4| 4| 3| 2| | |
DAY ON TEST | 6| 6| 6| 6| 0| 6| 6| 6| 8| 5| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
250 MG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 50 |
Compression | | 4 |
Hemorrhage, Acute | | 2 2.5|
Hydrocephalus | | 4 2.5|
Pigmentation, Hemosiderin | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + | 50 |
Bacterium | | 1 |
Foreign Body | 2 3 | 6 2.5|
Inflammation, Chronic | 4 | 11 1.8|
Alveolar Epithelium, Hyperplasia | | 2 1.5|
Mediastinum, Bacterium, Multiple | | 1 |
Mediastinum, Foreign Body | | 1 4.0|
Mediastinum, Hemorrhage, Acute | | 3 3.7|
Mediastinum, Inflammation, Chronic | | |
Active | | 7 3.0|
Pleura, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + | 50 |
Foreign Body | | 1 2.0|
Inflammation, Chronic Active | 4 | 3 2.7|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + | 50 |
Foreign Body | | 1 2.0|
Hemorrhage, Acute | | 1 3.0|
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 4 |
Lens, Cataract | | 2 4.0|
Retina, Atrophy | | 2 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + M + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 2| 4| 4| 4| 3| 2| | |
DAY ON TEST | 6| 6| 6| 6| 0| 6| 6| 6| 8| 5| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
250 MG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 50 |
Cyst | | 1 |
Infarct, Chronic | | 1 2.0|
Mineralization | | 1 1.0|
Nephropathy, Chronic | | 26 1.3|
__________________________________________________________________________|____________|
Ureter | + | 15 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 48 |
Dilatation | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 7| 5| 6| 7| 5| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 0| 0| 0| 3| 5| 3| 3| 2| 8| 7| 2| 9| 3| 1| 5| 3| 3| 3| 3| 7| 3| 3| 3| 2| 8|
| 6| 6| 0| 0| 6| 0| 0| 6| 8| 3| 6| 9| 0| 7| 0| 0| 0| 1| 1| 0| 1| 1| 1| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + M + M + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X|
Clear Cell Focus | |
Degeneration, Cystic | 1 1 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Chronic | 1 1 3 2 1 2 2|
Inflammation, Necrotizing | |
Necrosis, Coagulative | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Acinus, Atrophy | 3 1 2 3 1 3 1 3 1 2 3|
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | 1 1 1 |
Edema | 2 |
Hyperkeratosis, Focal | |
Hyperplasia, Focal | |
Inflammation, Chronic Active | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 3 3 2 2 2 2 2 3 2 3 2 1 2 2 3 2 2 2 2 2 2 2|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 7| 5| 6| 7| 5| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 0| 0| 0| 3| 5| 3| 3| 2| 8| 7| 2| 9| 3| 1| 5| 3| 3| 3| 3| 7| 3| 3| 3| 2| 8|
| 6| 6| 0| 0| 6| 0| 0| 6| 8| 3| 6| 9| 0| 7| 0| 0| 0| 1| 1| 0| 1| 1| 1| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Degeneration, Fatty | 2 1 2 3 |
Hyperplasia | 1 2 1 2 2 2 |
Hypertrophy | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X |
Pars Distalis, Hemorrhage, Acute | 4 |
Pars Distalis, Hyperplasia | 3 2 2 1 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 1 2 2 2 2 2|
Follicular Cell, Hyperplasia | 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ductus Deferens | + + + + + + + + + + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + M M + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 1|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic Active | 3 2 2 2 2 2 2 2 1 1 2 2 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Mineralization | 1 1 1 1 1 1 1 |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 2 1 2 1 2 1|
Seminiferous Tubule, Atrophy | 2 4 4 4 4 4 3 4 3 4 4 4 4 4 4 4 4 3 4 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Reticulum Cell | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 7| 5| 6| 7| 5| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 0| 0| 0| 3| 5| 3| 3| 2| 8| 7| 2| 9| 3| 1| 5| 3| 3| 3| 3| 7| 3| 3| 3| 2| 8|
| 6| 6| 0| 0| 6| 0| 0| 6| 8| 3| 6| 9| 0| 7| 0| 0| 0| 1| 1| 0| 1| 1| 1| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Femoral, Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + M + + M + + + + M + M + M + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + M + M + + + M + +|
Hyperplasia, Cystic | 2 2 3 3 2 1 2 4 2 4 2 2 2 2 2 2 2 4|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Fibrosis | |
Hyperkeratosis | 4 |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X |
Hemorrhage, Acute | 3 2|
Hydrocephalus | 2 2 2 2 |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Chronic | 2 1 3 1 1 2 2 1 2 1|
Alveolar Epithelium, Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 3 4 |
Retina, Atrophy | 4 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 7| 5| 6| 7| 5| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 0| 0| 0| 3| 5| 3| 3| 2| 8| 7| 2| 9| 3| 1| 5| 3| 3| 3| 3| 7| 3| 3| 3| 2| 8|
| 6| 6| 0| 0| 6| 0| 0| 6| 8| 3| 6| 9| 0| 7| 0| 0| 0| 1| 1| 0| 1| 1| 1| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | |
Nephropathy, Chronic | 1 1 2 3 1 2 2 2 3 3 2 2 2 1 2 2 1 2 2 2 2 2 2 3|
__________________________________________________________________________|
Ureter | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urethra | + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 6| 7| 3| 7| 5| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 7| 6| 6| 7| 7| 5| 6| 7|
DAY ON TEST | 6| 3| 4| 1| 0| 3| 9| 3| 3| 3| 3| 3| 4| 3| 1| 7| 3| 3| 5| 4| 3| 3| 5| 6| 3|
| 1| 1| 9| 8| 7| 7| 3| 1| 1| 2| 2| 2| 1| 2| 7| 1| 2| 2| 2| 2| 2| 2| 7| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X |
Clear Cell Focus | X |
Degeneration, Cystic | |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic | 1 1 1 2|
Inflammation, Necrotizing | 2 |
Necrosis, Coagulative | 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 4|
Acinus, Atrophy | 2 2 1 1 2 2 3|
Duct, Ectasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | 1 1 |
Edema | |
Hyperkeratosis, Focal | 1 |
Hyperplasia, Focal | 3 4 |
Inflammation, Chronic Active | |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 3 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 3 2 2 2 3|
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 6| 7| 3| 7| 5| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 7| 6| 6| 7| 7| 5| 6| 7|
DAY ON TEST | 6| 3| 4| 1| 0| 3| 9| 3| 3| 3| 3| 3| 4| 3| 1| 7| 3| 3| 5| 4| 3| 3| 5| 6| 3|
| 1| 1| 9| 8| 7| 7| 3| 1| 1| 2| 2| 2| 1| 2| 7| 1| 2| 2| 2| 2| 2| 2| 7| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Degeneration, Fatty | 2 |
Hyperplasia | 2 2 2 2 1 2 |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 2 2 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X |
Pars Distalis, Hemorrhage, Acute | |
Pars Distalis, Hyperplasia | 2 2 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 2 1|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Ductus Deferens | + + + + + + + + +|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Preputial Gland | + M + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Chronic Active | 1 3 1 2 2 1 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Chronic Active | 2 1 2 3 2 2 2 2 2 1 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Mineralization | 1 |
Interstitial Cell, Hyperplasia | 2 1 2 2 2 1 1 2 1 1 1 |
Seminiferous Tubule, Atrophy | 4 2 3 3 4 4 4 3 2 4 4 4 4 4 4 4 2 4 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Reticulum Cell | 2 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 6| 7| 3| 7| 5| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 7| 6| 6| 7| 7| 5| 6| 7|
DAY ON TEST | 6| 3| 4| 1| 0| 3| 9| 3| 3| 3| 3| 3| 4| 3| 1| 7| 3| 3| 5| 4| 3| 3| 5| 6| 3|
| 1| 1| 9| 8| 7| 7| 3| 1| 1| 2| 2| 2| 1| 2| 7| 1| 2| 2| 2| 2| 2| 2| 7| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Femoral, Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 2 |
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + + + M M + + + + + + I + + + + M M + + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + + + + M + M + + + + + + M + +|
Hyperplasia, Cystic | 4 2 2 2 2 2 2 4 2 2 2 1 4 2 1 2 3 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 4 |
Fibrosis | 3 |
Hyperkeratosis | 4 |
Inflammation, Chronic Active | 3 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
Hemorrhage, Acute | 3 |
Hydrocephalus | 2 2 3 |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 2 |
Inflammation, Chronic | 1 2 2 2 2 2 2 2 2 3 1|
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 3 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + + M + + + + M + + + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 6| 7| 3| 7| 5| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 7| 6| 6| 7| 7| 5| 6| 7|
DAY ON TEST | 6| 3| 4| 1| 0| 3| 9| 3| 3| 3| 3| 3| 4| 3| 1| 7| 3| 3| 5| 4| 3| 3| 5| 6| 3|
| 1| 1| 9| 8| 7| 7| 3| 1| 1| 2| 2| 2| 1| 2| 7| 1| 2| 2| 2| 2| 2| 2| 7| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | 3 |
Nephropathy, Chronic | 2 3 3 1 1 2 2 3 2 2 1 2 2 2 2 3 2 2 3 3 1 2 2|
__________________________________________________________________________|
Ureter | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urethra | + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + M + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 49 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 49 |
Parasite Metazoan | | 6 |
__________________________________________________________________________|____________|
Intestine Small | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 49 |
__________________________________________________________________________|____________|
Liver | | 50 |
Basophilic Focus | | 24 |
Clear Cell Focus | | 1 |
Degeneration, Cystic | | 2 1.0|
Hepatodiaphragmatic Nodule | | 2 |
Inflammation, Chronic | | 11 1.5|
Inflammation, Necrotizing | | 1 2.0|
Necrosis, Coagulative | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 49 |
Inflammation, Chronic Active | | 4 4.0|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Inflammation, Chronic Active | | 2 3.5|
Acinus, Atrophy | | 18 2.0|
Duct, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Acanthosis, Focal | | 5 1.0|
Edema | | 1 2.0|
Hyperkeratosis, Focal | | 1 1.0|
Hyperplasia, Focal | | 2 3.5|
Inflammation, Chronic Active | | 1 2.0|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 50 |
Inflammation, Chronic Active | | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 49 |
__________________________________________________________________________|____________|
Heart | | 50 |
Cardiomyopathy, Chronic | | 45 2.2|
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Accessory Adrenal Cortical Nodule | | 1 |
Degeneration, Fatty | | 5 2.0|
Hyperplasia | | 12 1.8|
Hypertrophy | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Hyperplasia | | 13 2.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 49 |
__________________________________________________________________________|____________|
Pituitary Gland | | 49 |
Pars Distalis, Cyst | | 6 |
Pars Distalis, Hemorrhage, Acute | | 1 4.0|
Pars Distalis, Hyperplasia | | 9 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
C-Cell, Hyperplasia | | 14 1.7|
Follicular Cell, Hyperplasia | | 5 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 43 |
__________________________________________________________________________|____________|
Ductus Deferens | | 19 |
__________________________________________________________________________|____________|
Epididymis | | 48 |
Inflammation, Chronic Active | | 2 2.0|
__________________________________________________________________________|____________|
Preputial Gland | | 48 |
Hyperplasia | | 2 3.5|
Inflammation, Chronic Active | | 45 1.9|
__________________________________________________________________________|____________|
Prostate | | 50 |
Cyst | | 1 |
Inflammation, Chronic Active | | 24 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | | 48 |
__________________________________________________________________________|____________|
Testes | | 50 |
Cyst | | 1 |
Mineralization | | 8 1.0|
Interstitial Cell, Hyperplasia | | 27 1.3|
Seminiferous Tubule, Atrophy | | 40 3.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Femoral, Hyperplasia, Reticulum Cell | | 1 2.0|
Femoral, Myelofibrosis | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
__________________________________________________________________________|____________|
Spleen | | 50 |
Fibrosis | | 3 2.7|
Hematopoietic Cell Proliferation | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | | 38 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 42 |
Hyperplasia, Cystic | | 38 2.3|
__________________________________________________________________________|____________|
Skin | | 50 |
Acanthosis | | 1 4.0|
Fibrosis | | 1 3.0|
Hyperkeratosis | | 2 4.0|
Inflammation, Chronic Active | | 3 3.3|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Compression | | 7 |
Hemorrhage, Acute | | 3 2.7|
Hydrocephalus | | 7 2.1|
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Foreign Body | | 2 2.5|
Inflammation, Chronic | | 21 1.8|
Alveolar Epithelium, Hyperplasia | | 4 2.3|
__________________________________________________________________________|____________|
Nose | | 50 |
Inflammation, Chronic Active | | 2 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 3 1.7|
__________________________________________________________________________|____________|
Trachea | | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
Lens, Cataract | | 3 3.3|
Retina, Atrophy | | 3 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 47 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Inflammation, Necrotizing | | 1 3.0|
Nephropathy, Chronic | | 47 2.0|
__________________________________________________________________________|____________|
Ureter | | 50 |
__________________________________________________________________________|____________|
Urethra | | 6 |
__________________________________________________________________________|____________|
Urinary Bladder | | 49 |
Dilatation | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 3| 7| 7| 6| 2| 4| 6| 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 6| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 9| 8| 3| 3| 7| 7| 1| 9| 3| 3| 0| 3| 6| 3| 7| 3| 1| 3| 8| 3| 1|
| 0| 0| 4| 0| 4| 0| 0| 0| 4| 1| 6| 5| 0| 0| 6| 0| 3| 0| 7| 1| 5| 1| 9| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
62.5 MG/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | 3|
Inflammation, Chronic Active | 2 3|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + A + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + M + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X |
Clear Cell Focus | X X |
Degeneration, Cystic | |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Nodular | 2 |
Inflammation, Chronic | 1 1 1 |
Necrosis, Coagulative | 2 |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Chronic | 4 |
Inflammation, Chronic Active | 4 4 4 4 4 4|
Mineralization | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 1 2 3 1 3 1 1 2 |
Acinus, Hyperplasia | 2 |
Duct, Ectasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | 1 1 1 1 1 1 |
Hyperplasia, Focal | 2 |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 3| 7| 7| 6| 2| 4| 6| 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 6| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 9| 8| 3| 3| 7| 7| 1| 9| 3| 3| 0| 3| 6| 3| 7| 3| 1| 3| 8| 3| 1|
| 0| 0| 4| 0| 4| 0| 0| 0| 4| 1| 6| 5| 0| 0| 6| 0| 3| 0| 7| 1| 5| 1| 9| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
62.5 MG/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 3 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 3 3 2 |
Inflammation, Chronic Active | 2 |
Atrium, Thrombosis | X |
Coronary Artery, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 2 2 2|
Hyperplasia | 2 2 2 1 2 2 2 2 |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 3 1 2 2 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + M M + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 1 2 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Hemorrhage, Acute | 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ductus Deferens | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 |
Inflammation, Chronic Active | 3 2 1 2 2 1 2 2 2 3 4 2 2 2 2 2 2 1 2 1 1 1|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic Active | 1 2 2 2 2 2 2 3 2 2 2 1 2 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 1 1 1 1 |
Interstitial Cell, Hyperplasia | 1 2 2 1 1 1 2 1 1 1 1 2 2 2 1 2 2 2|
Seminiferous Tubule, Atrophy | 4 4 4 2 4 4 4 4 4 4 4 4 4 4 4 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 3| 7| 7| 6| 2| 4| 6| 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 6| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 9| 8| 3| 3| 7| 7| 1| 9| 3| 3| 0| 3| 6| 3| 7| 3| 1| 3| 8| 3| 1|
| 0| 0| 4| 0| 4| 0| 0| 0| 4| 1| 6| 5| 0| 0| 6| 0| 3| 0| 7| 1| 5| 1| 9| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
62.5 MG/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X|
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | |
Infarct, Chronic | 3 |
__________________________________________________________________________|
Thymus | + + + + + + M M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + M M + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 1 2 1 1 2 2 4 2 1 2 2 1 1 2 2 1 1 2 3 1 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | 4 3 |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X |
Hemorrhage, Acute | 4 |
Hydrocephalus | 2 3 3 |
__________________________________________________________________________|
Spinal Cord | |
White Matter, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 2 2 2|
Inflammation, Chronic | 2 2 2 |
Alveolar Epithelium, Hyperplasia | 2 2 |
Mediastinum, Hemorrhage, Acute | 3 |
Mediastinum, Inflammation, Chronic | |
Active | 2 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + A + + + + + + + + + + + + + + +|
Fibrosis | 2|
Foreign Body | 3 2 2 2 2 |
Inflammation, Chronic Active | 2 2 2 3 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 3| 7| 7| 6| 2| 4| 6| 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 6| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 9| 8| 3| 3| 7| 7| 1| 9| 3| 3| 0| 3| 6| 3| 7| 3| 1| 3| 8| 3| 1|
| 0| 0| 4| 0| 4| 0| 0| 0| 4| 1| 6| 5| 0| 0| 6| 0| 3| 0| 7| 1| 5| 1| 9| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
62.5 MG/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | 3|
Inflammation, Chronic Active | 2 3|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 4 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + M + + + M I + + + + + + + + + + + + + +|
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hemorrhage, Chronic | 4 |
Nephropathy, Chronic | 2 2 2 2 2 1 2 2 2 1 2 1 2 2 2 2 2 2 2 1 3 1 3 2|
__________________________________________________________________________|
Ureter | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 7| 5| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 2| 2| 3| 2| 3| 8| 3| 3| 3| 3| 3| 3| 0| 1| 3| 3| 4| 3| 9| 3|
| 7| 1| 1| 1| 1| 2| 2| 1| 4| 1| 3| 1| 2| 2| 2| 2| 2| 3| 9| 2| 2| 1| 2| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
62.5 MG/ | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + + + M + + + + + + M + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X |
Clear Cell Focus | |
Degeneration, Cystic | 2 |
Hepatodiaphragmatic Nodule | |
Hyperplasia, Nodular | |
Inflammation, Chronic | 1 1 1 |
Necrosis, Coagulative | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Chronic | |
Inflammation, Chronic Active | 4 4 4 4 4 4 4|
Mineralization | 2 2 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 3 1 2 2 3 1 2 2 3 1|
Acinus, Hyperplasia | 3 |
Duct, Ectasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | 1 1 1 |
Hyperplasia, Focal | |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 4 |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 7| 5| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 2| 2| 3| 2| 3| 8| 3| 3| 3| 3| 3| 3| 0| 1| 3| 3| 4| 3| 9| 3|
| 7| 1| 1| 1| 1| 2| 2| 1| 4| 1| 3| 1| 2| 2| 2| 2| 2| 3| 9| 2| 2| 1| 2| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
62.5 MG/ | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 2 2 2 2 2 2 1 1 1 2 2 2 2 2 2 2 3 2 2 2 2|
Inflammation, Chronic Active | 2|
Atrium, Thrombosis | X X X X|
Coronary Artery, Inflammation, | |
Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 2 2 |
Hyperplasia | 1 2 1 2 2 2 3 2 2 2 2|
Hypertrophy | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X|
Pars Distalis, Hyperplasia | 2 2 2 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 1 1 2 2 2 2 2 2|
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Hemorrhage, Acute | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ductus Deferens | + + + + + + + + + + + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + M + + + + + + + M + + + + + + + +|
Hyperplasia | 2 2 |
Inflammation, Chronic Active | 2 2 2 1 2 3 3 1 1 1 2 2 2 2 2 1 2 4 2 1 1|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Inflammation, Chronic Active | 2 2 1 2 2 1 1 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1|
Interstitial Cell, Hyperplasia | 1 2 1 2 2 1 2 1 1 1 2 1 1 2 2|
Seminiferous Tubule, Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 7| 5| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 2| 2| 3| 2| 3| 8| 3| 3| 3| 3| 3| 3| 0| 1| 3| 3| 4| 3| 9| 3|
| 7| 1| 1| 1| 1| 2| 2| 1| 4| 1| 3| 1| 2| 2| 2| 2| 2| 3| 9| 2| 2| 1| 2| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
62.5 MG/ | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 3 |
Hematopoietic Cell Proliferation | 2 |
Infarct, Chronic | |
__________________________________________________________________________|
Thymus | + + M + + + + + + + M M + + + M + + + M + M M + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M M + + + + + + + + + + + + M + M + + + + + +|
Hyperplasia, Cystic | 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1 1 1 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | 2 |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Hemorrhage, Acute | |
Hydrocephalus | |
__________________________________________________________________________|
Spinal Cord | + |
White Matter, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 3 |
Inflammation, Chronic | 3 2 3 2 2 1 2 3|
Alveolar Epithelium, Hyperplasia | 1 1 3 |
Mediastinum, Hemorrhage, Acute | |
Mediastinum, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Nose | + + + + + + + + M + + + + + + + + + + + + + + + +|
Fibrosis | |
Foreign Body | 2 2 2 2|
Inflammation, Chronic Active | 2 3 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 7| 5| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 2| 2| 3| 2| 3| 8| 3| 3| 3| 3| 3| 3| 0| 1| 3| 3| 4| 3| 9| 3|
| 7| 1| 1| 1| 1| 2| 2| 1| 4| 1| 3| 1| 2| 2| 2| 2| 2| 3| 9| 2| 2| 1| 2| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
62.5 MG/ | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | M + |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + M + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hemorrhage, Chronic | |
Nephropathy, Chronic | 2 3 1 2 2 2 2 1 2 2 1 2 2 3 2 1 2 1 1 2 2 2 2 2 3|
__________________________________________________________________________|
Ureter | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + A + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
62.5 MG/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
Hemorrhage, Acute | | 1 3.0|
Inflammation, Chronic Active | | 2 2.5|
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 49 |
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 47 |
Parasite Metazoan | | 7 |
__________________________________________________________________________|____________|
Intestine Small | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 50 |
__________________________________________________________________________|____________|
Liver | | 50 |
Basophilic Focus | | 17 |
Clear Cell Focus | | 2 |
Degeneration, Cystic | | 1 2.0|
Hepatodiaphragmatic Nodule | | 1 |
Hyperplasia, Nodular | | 1 2.0|
Inflammation, Chronic | | 6 1.0|
Necrosis, Coagulative | | 1 2.0|
Vacuolization Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 49 |
Hemorrhage, Chronic | | 1 4.0|
Inflammation, Chronic Active | | 13 4.0|
Mineralization | | 3 2.0|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Acinus, Atrophy | | 22 1.8|
Acinus, Hyperplasia | | 2 2.5|
Duct, Ectasia | | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Acanthosis, Focal | | 9 1.0|
Hyperplasia, Focal | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 49 |
__________________________________________________________________________|____________|
Tooth | | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
62.5 MG/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Dysplasia | | 1 4.0|
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 48 |
__________________________________________________________________________|____________|
Heart | | 50 |
Cardiomyopathy, Chronic | | 48 2.1|
Inflammation, Chronic Active | | 2 2.0|
Atrium, Thrombosis | | 5 |
Coronary Artery, Inflammation, | | |
Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Degeneration, Fatty | | 7 1.9|
Hyperplasia | | 19 1.9|
Hypertrophy | | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Hyperplasia | | 18 2.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 46 |
__________________________________________________________________________|____________|
Pituitary Gland | | 50 |
Pars Distalis, Cyst | | 6 |
Pars Distalis, Hyperplasia | | 8 1.9|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
C-Cell, Hyperplasia | | 16 1.6|
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Hemorrhage, Acute | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 50 |
__________________________________________________________________________|____________|
Ductus Deferens | | 25 |
__________________________________________________________________________|____________|
Epididymis | | 50 |
__________________________________________________________________________|____________|
Preputial Gland | | 47 |
Hyperplasia | | 4 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
62.5 MG/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 43 1.9|
__________________________________________________________________________|____________|
Prostate | | 50 |
Cyst | | 2 |
Inflammation, Chronic Active | | 23 1.8|
__________________________________________________________________________|____________|
Seminal Vesicle | | 49 |
__________________________________________________________________________|____________|
Testes | | 50 |
Mineralization | | 16 1.1|
Interstitial Cell, Hyperplasia | | 33 1.5|
Seminiferous Tubule, Atrophy | | 39 3.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
__________________________________________________________________________|____________|
Lymph Node | | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
Cyst | | 6 |
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | | 50 |
Fibrosis | | 2 3.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Infarct, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | | 40 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 43 |
Hyperplasia, Cystic | | 43 1.4|
__________________________________________________________________________|____________|
Skin | | 50 |
Acanthosis | | 1 2.0|
Hyperkeratosis | | 3 3.0|
Inflammation, Chronic Active | | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Compression | | 3 |
Hemorrhage, Acute | | 1 4.0|
Hydrocephalus | | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
62.5 MG/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
White Matter, Degeneration | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Foreign Body | | 6 2.5|
Inflammation, Chronic | | 11 2.2|
Alveolar Epithelium, Hyperplasia | | 5 1.8|
Mediastinum, Hemorrhage, Acute | | 1 3.0|
Mediastinum, Inflammation, Chronic | | |
Active | | 2 2.5|
__________________________________________________________________________|____________|
Nose | | 48 |
Fibrosis | | 1 2.0|
Foreign Body | | 9 2.1|
Inflammation, Chronic Active | | 6 2.3|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 3 1.3|
__________________________________________________________________________|____________|
Trachea | | 50 |
Hemorrhage, Acute | | 1 3.0|
Inflammation, Chronic Active | | 2 2.5|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Lens, Cataract | | 1 4.0|
Retina, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 45 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Cyst | | 1 |
Hemorrhage, Chronic | | 1 4.0|
Nephropathy, Chronic | | 49 1.9|
__________________________________________________________________________|____________|
Ureter | | 48 |
__________________________________________________________________________|____________|
Urethra | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7| 2| 6| 5| 6| 7| 7| 5| 6| 7| 6| 4|
DAY ON TEST | 2| 1| 3| 3| 3| 6| 3| 3| 5| 3| 3| 3| 3| 3| 7| 2| 5| 9| 3| 3| 8| 3| 3| 4| 9|
| 3| 5| 0| 0| 0| 1| 0| 4| 6| 0| 0| 0| 1| 1| 8| 7| 5| 4| 1| 1| 7| 5| 1| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
125 MG/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | M + + + + + + + + + + + + + A + A A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | M + + + + + + + + + + + + + + + A + + M + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X |
Degeneration, Cystic | |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic | 1 2 1 1 1 1 2 1 |
Inflammation, Necrotizing | 2 |
Necrosis, Coagulative | |
Vacuolization Cytoplasmic | 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Chronic | |
Inflammation, Chronic Active | 3 4 4 4 |
Mineralization | 2 2 2 1 |
Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Inflammation, Chronic Active | 2 |
Acinus, Atrophy | 3 2 1 1 1 2 2 3 |
Acinus, Hyperplasia | |
Duct, Ectasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Hyperkeratosis, Diffuse | |
Hyperkeratosis, Focal | 1 1 1 1 1 |
Hyperplasia, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7| 2| 6| 5| 6| 7| 7| 5| 6| 7| 6| 4|
DAY ON TEST | 2| 1| 3| 3| 3| 6| 3| 3| 5| 3| 3| 3| 3| 3| 7| 2| 5| 9| 3| 3| 8| 3| 3| 4| 9|
| 3| 5| 0| 0| 0| 1| 0| 4| 6| 0| 0| 0| 1| 1| 8| 7| 5| 4| 1| 1| 7| 5| 1| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
125 MG/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 1 2 2 3 2 3 2 2 2 2 2 2 2 2 2 3 3 3 3 1 2 2 2 |
Foreign Body | |
Inflammation, Chronic Active | |
Atrium, Thrombosis | |
Coronary Artery, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Degeneration, Fatty | 2 1 2 2 |
Hyperplasia | 2 2 2 2 2 1 1 2 2 2 |
Necrosis, Coagulative | 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 1 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X X X |
Pars Distalis, Hyperplasia | 2 2 3 2 1 2 3 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
C-Cell, Hyperplasia | 2 1 2 2 2 2 2 1 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Ductus Deferens | + + + + + + + + + + +|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + I|
Hyperplasia | 2 |
Inflammation, Chronic Active | 1 3 3 2 2 3 2 2 2 2 2 2 2 2 2 1 2 2 2 1 2 |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 2 2 1 3 2 2 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7| 2| 6| 5| 6| 7| 7| 5| 6| 7| 6| 4|
DAY ON TEST | 2| 1| 3| 3| 3| 6| 3| 3| 5| 3| 3| 3| 3| 3| 7| 2| 5| 9| 3| 3| 8| 3| 3| 4| 9|
| 3| 5| 0| 0| 0| 1| 0| 4| 6| 0| 0| 0| 1| 1| 8| 7| 5| 4| 1| 1| 7| 5| 1| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
125 MG/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Chronic | |
Inflammation, Chronic Active | |
Mineralization | 1 1 1 1 1 |
Interstitial Cell, Hyperplasia | 2 1 1 1 2 1 1 1 2 1 1 1 2 1|
Seminiferous Tubule, Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Reticulum Cell | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Cyst | |
Mediastinal, Edema, Acute | |
Mediastinal, Hemorrhage, Acute | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + + + +|
Cyst | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 3 3 |
__________________________________________________________________________|
Thymus | + + + + + M M + M M + M + M + + + M + + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + M + + M + + + + + + + +|
Hyperplasia, Cystic | 2 3 3 1 2 1 2 2 1 2 1 2 4 3 2 4 3 2 2 2|
Inflammation, Chronic Active | 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Hyperkeratosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
Hemorrhage, Acute | 2 |
Hydrocephalus | 3 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium, Multiple | |
Foreign Body | 2 3 3 3 3 |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7| 2| 6| 5| 6| 7| 7| 5| 6| 7| 6| 4|
DAY ON TEST | 2| 1| 3| 3| 3| 6| 3| 3| 5| 3| 3| 3| 3| 3| 7| 2| 5| 9| 3| 3| 8| 3| 3| 4| 9|
| 3| 5| 0| 0| 0| 1| 0| 4| 6| 0| 0| 0| 1| 1| 8| 7| 5| 4| 1| 1| 7| 5| 1| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
125 MG/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic | 1 2 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Mediastinum, Inflammation, Chronic | |
Active | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Acanthosis | 2 |
Hyperkeratosis | 2 |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Infarct, Chronic | |
Mineralization | |
Nephropathy, Chronic | 2 1 2 2 2 2 1 1 2 1 2 2 3 1 1 2 1 3 2 2 2 2 1|
__________________________________________________________________________|
Ureter | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 7| 7| 5| 5| 7| 5| 6| 5| 5| 7| 6| 7| 6| 5| 6| 6| 7| 7| 4| 6|
DAY ON TEST | 4| 1| 3| 3| 5| 3| 3| 4| 3| 3| 5| 9| 9| 6| 3| 8| 3| 9| 5| 1| 1| 3| 3| 6| 6|
| 5| 3| 1| 1| 5| 2| 2| 9| 8| 2| 5| 5| 8| 1| 2| 2| 2| 4| 7| 9| 1| 2| 2| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
125 MG/ | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 4|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | M + M + A + + + + + + + + + M + + + A + + + + M|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + M M + + M + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X |
Degeneration, Cystic | 2 1 1 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Chronic | 2 1 2 1 1 |
Inflammation, Necrotizing | 1 |
Necrosis, Coagulative | 3 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Chronic | 4 |
Inflammation, Chronic Active | 4 4 4 2 4 |
Mineralization | 1 |
Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X |
Inflammation, Chronic Active | |
Acinus, Atrophy | 1 1 2 2 1 1 2 2 1 3 1 2 2|
Acinus, Hyperplasia | 3 |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | 1 1 1 1 1 1 1 2 1 1|
Hyperkeratosis, Diffuse | 1 2|
Hyperkeratosis, Focal | 1 1 2 |
Hyperplasia, Focal | 3 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 7| 7| 5| 5| 7| 5| 6| 5| 5| 7| 6| 7| 6| 5| 6| 6| 7| 7| 4| 6|
DAY ON TEST | 4| 1| 3| 3| 5| 3| 3| 4| 3| 3| 5| 9| 9| 6| 3| 8| 3| 9| 5| 1| 1| 3| 3| 6| 6|
| 5| 3| 1| 1| 5| 2| 2| 9| 8| 2| 5| 5| 8| 1| 2| 2| 2| 4| 7| 9| 1| 2| 2| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
125 MG/ | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 3|
Foreign Body | 4 4 |
Inflammation, Chronic Active | 4 4 4 |
Atrium, Thrombosis | X |
Coronary Artery, Inflammation, | |
Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Degeneration, Fatty | 1 2 2 |
Hyperplasia | 1 2 3 2 1 3 1 2 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 2 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + I + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + +|
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hyperplasia | 2 2 2 2 |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3|
C-Cell, Hyperplasia | 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ductus Deferens | + + + + + + + + + + +|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 2 2 2 2 2 2 1 2 1 2 2 2 2 2 2 1 2 2 2 1|
Duct, Ectasia | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 3 1 1 1 2 2 2 2 1 3 2 |
__________________________________________________________________________|
Seminal Vesicle | M + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 7| 7| 5| 5| 7| 5| 6| 5| 5| 7| 6| 7| 6| 5| 6| 6| 7| 7| 4| 6|
DAY ON TEST | 4| 1| 3| 3| 5| 3| 3| 4| 3| 3| 5| 9| 9| 6| 3| 8| 3| 9| 5| 1| 1| 3| 3| 6| 6|
| 5| 3| 1| 1| 5| 2| 2| 9| 8| 2| 5| 5| 8| 1| 2| 2| 2| 4| 7| 9| 1| 2| 2| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
125 MG/ | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Chronic | 4 |
Inflammation, Chronic Active | 3 |
Mineralization | 1 1 |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 2 2 1 2 1 1 1 1 1 2 2 1 1 |
Seminiferous Tubule, Atrophy | 4 4 4 4 4 4 3 3 4 4 3 4 4 4 3 3 4 4 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Reticulum Cell | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Cyst | X |
Mediastinal, Edema, Acute | 2 |
Mediastinal, Hemorrhage, Acute | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 3 |
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + M + + + M M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + M M + + + + + M + + + + + M|
Hyperplasia, Cystic | 1 4 3 2 1 2 2 2 3 1 1 1 4 3 3 2 1 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Hemorrhage, Acute | |
Hydrocephalus | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium, Multiple | X|
Foreign Body | 2 3 2 2 |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 7| 7| 5| 5| 7| 5| 6| 5| 5| 7| 6| 7| 6| 5| 6| 6| 7| 7| 4| 6|
DAY ON TEST | 4| 1| 3| 3| 5| 3| 3| 4| 3| 3| 5| 9| 9| 6| 3| 8| 3| 9| 5| 1| 1| 3| 3| 6| 6|
| 5| 3| 1| 1| 5| 2| 2| 9| 8| 2| 5| 5| 8| 1| 2| 2| 2| 4| 7| 9| 1| 2| 2| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
125 MG/ | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic | 1 1 1 2 2 2 3 2 2 3 2 3|
Alveolar Epithelium, Hyperplasia | 2 2 |
Mediastinum, Inflammation, Chronic | |
Active | 2 3 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Acanthosis | |
Hyperkeratosis | |
__________________________________________________________________________|
Eye | + + + |
Lens, Cataract | 4 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Infarct, Chronic | 3 |
Mineralization | 1 |
Nephropathy, Chronic | 1 2 3 1 2 2 2 1 3 2 2 2 3 2 2 3 2 2 3 1 3 2 2|
__________________________________________________________________________|
Ureter | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urethra | + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 1| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
125 MG/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 50 |
Inflammation, Chronic Active | | 2 4.0|
__________________________________________________________________________|____________|
Intestine Large | + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A | 39 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 49 |
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 47 |
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Small | + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A | 45 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 49 |
__________________________________________________________________________|____________|
Liver | + | 50 |
Basophilic Focus | | 18 |
Degeneration, Cystic | | 3 1.3|
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | | 2 |
Inflammation, Chronic | | 13 1.3|
Inflammation, Necrotizing | | 2 1.5|
Necrosis, Coagulative | | 1 3.0|
Vacuolization Cytoplasmic | | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 46 |
Hemorrhage, Chronic | | 1 4.0|
Inflammation, Chronic Active | | 9 3.7|
Mineralization | | 5 1.6|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + | 50 |
Ectopic Tissue | | 1 |
Inflammation, Chronic Active | | 1 2.0|
Acinus, Atrophy | | 21 1.7|
Acinus, Hyperplasia | | 1 3.0|
Duct, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + | 50 |
__________________________________________________________________________|____________|
Stomach | + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 50 |
Acanthosis, Focal | | 23 1.0|
Hyperkeratosis, Diffuse | | 2 1.5|
Hyperkeratosis, Focal | | 8 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 1| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
125 MG/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Focal | | 3 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 50 |
__________________________________________________________________________|____________|
Tooth | + | 50 |
Inflammation, Chronic Active | | 2 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 49 |
__________________________________________________________________________|____________|
Heart | + | 50 |
Cardiomyopathy, Chronic | 2 | 46 2.2|
Foreign Body | | 2 4.0|
Inflammation, Chronic Active | | 3 4.0|
Atrium, Thrombosis | | 1 |
Coronary Artery, Inflammation, | | |
Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + | 49 |
Atrophy | | 1 3.0|
Degeneration, Fatty | | 7 1.7|
Hyperplasia | | 18 1.8|
Necrosis, Coagulative | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + | 50 |
Hyperplasia | | 13 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + | 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + | 49 |
Pars Distalis, Cyst | | 9 |
Pars Distalis, Hyperplasia | | 11 2.1|
Pars Intermedia, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + | 50 |
Inflammation, Chronic Active | | 1 3.0|
C-Cell, Hyperplasia | | 14 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 1| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
125 MG/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ductus Deferens | | 22 |
__________________________________________________________________________|____________|
Epididymis | + | 50 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + | 49 |
Hyperplasia | | 1 2.0|
Inflammation, Chronic Active | 1 | 42 1.9|
Duct, Ectasia | | 2 3.5|
__________________________________________________________________________|____________|
Prostate | + | 50 |
Inflammation, Chronic Active | 3 | 22 2.1|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 48 |
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Testes | + | 50 |
Hemorrhage, Chronic | | 1 4.0|
Inflammation, Chronic Active | | 1 3.0|
Mineralization | | 7 1.0|
Interstitial Cell, Hyperplasia | | 33 1.3|
Seminiferous Tubule, Atrophy | | 34 3.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 50 |
Femoral, Hyperplasia, Reticulum Cell | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + | 50 |
Mediastinal, Cyst | | 1 |
Mediastinal, Edema, Acute | | 1 2.0|
Mediastinal, Hemorrhage, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 49 |
Cyst | | 2 |
__________________________________________________________________________|____________|
Spleen | + | 50 |
Fibrosis | | 2 2.5|
Hematopoietic Cell Proliferation | | 3 3.0|
__________________________________________________________________________|____________|
Thymus | M | 38 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 42 |
Hyperplasia, Cystic | 4 | 39 2.2|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + | 50 |
Acanthosis | | 1 3.0|
Hyperkeratosis | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 1| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
125 MG/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 50 |
Compression | X | 4 |
Hemorrhage, Acute | | 1 2.0|
Hydrocephalus | | 3 3.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 50 |
Bacterium, Multiple | | 1 |
Foreign Body | | 9 2.6|
Inflammation, Chronic | | 15 1.9|
Alveolar Epithelium, Hyperplasia | | 3 2.0|
Mediastinum, Inflammation, Chronic | | |
Active | | 4 2.8|
__________________________________________________________________________|____________|
Nose | + | 50 |
Inflammation, Chronic Active | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Acanthosis | | 1 2.0|
Hyperkeratosis | | 1 2.0|
__________________________________________________________________________|____________|
Eye | | 5 |
Lens, Cataract | | 1 4.0|
Retina, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | I | 48 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 50 |
Cyst | | 2 |
Infarct, Chronic | | 1 3.0|
Mineralization | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05038-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIMETHOXANE Date: 05/05/97
Route: GAVAGE Time: 09:18:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 1| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
125 MG/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy, Chronic | 1 | 47 1.9|
__________________________________________________________________________|____________|
Ureter | + | 47 |
__________________________________________________________________________|____________|
Urethra | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
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