TR 354 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/05/94
EXP: 05038 DIMETHOXANE TIME: 07:44:56
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56213
CONT: N01CP9565302 CAS: 828-00-2
PATHOLOGIST: J. TOFT S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/05/94
EXP: 05038 DIMETHOXANE TIME: 07:44:56
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56213
CONT: N01CP9565302 CAS: 828-00-2
PATHOLOGIST: J. TOFT S. EUSTIS
DIMETHOXANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 25 CENSORED DEATHS 12 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 349 450 500 507 571 588 593 599 617 641 |
| 642 652 656 661 666 670 673 683 706 706 |
| 717 718 726 726 726 |
| CENSORED DEATHS |
| 465 465 465 465 465 465 465 465 465 465 |
| 537 557 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 62.5 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 19 CENSORED DEATHS 13 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 380 383 416 514 515 563 593 617 619 641 |
| 674 677 689 694 695 706 722 722 724 |
| CENSORED DEATHS |
| 271 403 465 465 465 465 465 465 465 465 |
| 465 465 534 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 125 MG/ KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 18 CENSORED DEATHS 21 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 371 423 493 515 555 556 561 561 587 598 |
| 611 619 634 645 682 694 694 695 |
| CENSORED DEATHS |
| 278 465 465 465 465 465 465 465 465 465 |
| 465 538 549 555 555 557 613 627 635 641 |
| 665 |
| |
==================================================================================
DIMETHOXANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 98.3 98.3 96.7 92.6 84.2 71.6 48.4 |
| | |
| | |
|62.5 MG/KG | 100.0 100.0 100.0 100.0 94.9 94.9 90.7 86.4 79.9 60.4 |
| | |
| | |
|125 MG/ KG | 100.0 100.0 100.0 100.0 96.6 96.6 92.5 78.8 69.0 57.9 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 62.5 MG/KG 125 MG/ KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 48.4% 60.4% 57.9% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.655N P=0.375N P=0.784N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 629.7 607.6 583.0 |
|NATURAL DEATHS (C) | (19.0) (26.5) (21.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 638.0 630.7 611.5 |
|(STANDARD ERROR) | (14.3) (16.7) (15.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DIMETHOXANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 18 CENSORED DEATHS 12 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 85 449 485 515 562 571 580 582 593 625 |
| 625 634 642 646 681 683 698 723 |
| CENSORED DEATHS |
| 267 465 465 465 465 465 465 465 465 465 |
| 465 498 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 125 MG/ KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 16 CENSORED DEATHS 13 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 128 515 526 533 541 544 599 607 670 677 |
| 706 709 714 726 726 726 |
| CENSORED DEATHS |
| 459 465 465 465 465 465 465 465 465 465 |
| 465 538 615 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 250 MG/ KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 15 CENSORED DEATHS 21 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 388 523 538 547 567 597 604 607 625 656 |
| 668 668 668 687 715 |
| CENSORED DEATHS |
| 15 205 256 257 297 465 465 465 465 465 |
| 465 465 465 465 465 515 538 538 544 554 |
| 557 |
| |
==================================================================================
DIMETHOXANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 98.3 98.3 98.3 98.3 98.3 94.6 92.5 82.0 71.5 63.1 |
| | |
| | |
|125 MG/ KG | 100.0 98.3 98.3 98.3 98.3 98.3 88.0 85.9 83.8 66.6 |
| | |
| | |
|250 MG/ KG | 100.0 100.0 100.0 100.0 98.2 98.2 93.6 83.3 75.5 62.5 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 125 MG/ KG 250 MG/ KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 63.1% 66.6% 62.5% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=1.000N P=0.721N P=1.000N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 576.6 602.9 603.9 |
|NATURAL DEATHS (C) | (33.6) (37.7) (21.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 628.2 642.3 591.7 |
|(STANDARD ERROR) | (17.8) (16.5) (20.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DIMETHOXANE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
62.5 MG/KG = 2
125 MG/ KG = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3 2
| 1 3 2 23 1 31
| 2 3112
| 13 3 1
P 90 + 2 21 1
E | 32 1 11 2
R | 1 1
C | 3 3 1 1
E 80 + 3 3 3 2 2
N | 33 1 1
T | 3 3 2 2
| 3 31 11 22
S 70 + 3 3 22
U | 11 2 2
R | 11 3
V | 1 1
I 60 + 1 12 2
V | 3 3
A | 11
L |
50 +
| 1 1
|
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 14 obs hidden.
DIMETHOXANE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
125 MG/ KG = 2
250 MG/ KG = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 3
| 1 2 3 1 2 3
|
| 1 1 2 323
95 + 1 1
| 22 3
| 1 22 1
| 3 3
P 90 + 11
E | 311 3
R | 2 2
C | 11 22
E 85 +
N | 1 1 2 2
T | 1 1
| 3 3 22
S 80 + 2 2
U | 3 3
R | 11 22
V | 11
I 75 + 3 3
V | 11
A | 2 2
L | 1 1
70 +
|
| 3 131
| 2 2
65 + 31 31
|
| 31 1
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 6 obs hidden.
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