TR 358 Rat Pathology Tables
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
Facility: Battelle Columbus Laboratory
Chemical CAS #: 303-47-9
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 2| 4| 5| 7| 7| 5| 7| 7| 6| 7| 6|
DAY ON TEST | 2| 9| 2| 2| 4| 2| 8| 2| 2| 2| 5| 6| 2| 2| 1| 6| 8| 2| 2| 2| 2| 2| 7| 2| 5|
| 8| 5| 8| 8| 8| 8| 9| 8| 8| 8| 4| 0| 8| 9| 6| 6| 3| 9| 9| 5| 9| 9| 3| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0 UG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pharynx | +|
Squamous Cell Carcinoma | X|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Multiple | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + M M + + + M M + + + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X|
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 2| 4| 5| 7| 7| 5| 7| 7| 6| 7| 6|
DAY ON TEST | 2| 9| 2| 2| 4| 2| 8| 2| 2| 2| 5| 6| 2| 2| 1| 6| 8| 2| 2| 2| 2| 2| 7| 2| 5|
| 8| 5| 8| 8| 8| 8| 9| 8| 8| 8| 4| 0| 8| 9| 6| 6| 3| 9| 9| 5| 9| 9| 3| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0 UG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X |
__________________________________________________________________________|
Ovary | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + M + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + I + + + + + + + + + + + + + + + +|
Femoral, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Leukemia Mononuclear | X X |
Mesenteric, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + + + M M M M +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Adenocarcinoma | |
Fibroadenoma | X X X X X |
Fibroadenoma, Multiple | X X |
__________________________________________________________________________|
Skin | + + + + M + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 2| 4| 5| 7| 7| 5| 7| 7| 6| 7| 6|
DAY ON TEST | 2| 9| 2| 2| 4| 2| 8| 2| 2| 2| 5| 6| 2| 2| 1| 6| 8| 2| 2| 2| 2| 2| 7| 2| 5|
| 8| 5| 8| 8| 8| 8| 9| 8| 8| 8| 4| 0| 8| 9| 6| 6| 3| 9| 9| 5| 9| 9| 3| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0 UG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + + |
__________________________________________________________________________|
Harderian Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 9| 2| 2| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 3| 7| 9| 3| 3| 3| 3| 3|
| 9| 7| 5| 9| 8| 0| 0| 0| 0| 0| 0| 0| 1| 0| 8| 1| 1| 1| 5| 5| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0 UG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Pharynx | |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Multiple | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + M + + + + M + M + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + I + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X|
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 9| 2| 2| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 3| 7| 9| 3| 3| 3| 3| 3|
| 9| 7| 5| 9| 8| 0| 0| 0| 0| 0| 0| 0| 1| 0| 8| 1| 1| 1| 5| 5| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0 UG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Adenoma | X X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Leukemia Mononuclear | X X X X X|
Mesenteric, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Thymus | M + + + + + + + M + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + + M + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Fibroadenoma | X X X X X X X X |
Fibroadenoma, Multiple | X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 9| 2| 2| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 3| 7| 9| 3| 3| 3| 3| 3|
| 9| 7| 5| 9| 8| 0| 0| 0| 0| 0| 0| 0| 1| 0| 8| 1| 1| 1| 5| 5| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0 UG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 UG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | |
__________________________________________________________________________|
Intestine Large | |
__________________________________________________________________________|
Intestine Large, Cecum | |
__________________________________________________________________________|
Intestine Large, Colon | |
__________________________________________________________________________|
Intestine Large, Rectum | |
__________________________________________________________________________|
Intestine Small | |
__________________________________________________________________________|
Intestine Small, Duodenum | |
__________________________________________________________________________|
Intestine Small, Ileum | |
__________________________________________________________________________|
Intestine Small, Jejunum | |
__________________________________________________________________________|
Liver | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pharynx | |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Salivary Glands | |
__________________________________________________________________________|
Stomach | |
__________________________________________________________________________|
Stomach, Forestomach | |
__________________________________________________________________________|
Stomach, Glandular | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | |
__________________________________________________________________________|
Adrenal Gland, Cortex | |
Adenoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | |
Leukemia Mononuclear | |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | |
Carcinoma, Multiple | |
__________________________________________________________________________|
Parathyroid Gland | |
__________________________________________________________________________|
Pituitary Gland | |
Pars Distalis, Adenoma | |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | |
C-Cell, Adenoma | |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 UG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Adenoma | |
__________________________________________________________________________|
Ovary | |
__________________________________________________________________________|
Uterus | |
Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Bone Marrow | |
Femoral, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | |
Mediastinal, Leukemia Mononuclear | |
Mesenteric, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Thymus | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | |
Adenocarcinoma | |
Fibroadenoma | |
Fibroadenoma, Multiple | |
__________________________________________________________________________|
Skin | |
Subcutaneous Tissue, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | |
Carcinoma, Metastatic, Pituitary | |
Gland | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Nose | |
__________________________________________________________________________|
Trachea | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 UG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Urinary Bladder | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| | A |
0 UG/KG | 3| 3| 3| 3| 3| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 48 |
__________________________________________________________________________|____________|
Intestine Small | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 49 |
__________________________________________________________________________|____________|
Liver | | 50 |
Leukemia Mononuclear | | 10 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pharynx | | 1 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Adenoma | | 2 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Leukemia Mononuclear | | 5 |
Pheochromocytoma Benign | | 3 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
Carcinoma, Multiple | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 39 |
__________________________________________________________________________|____________|
Pituitary Gland | | 49 |
Pars Distalis, Adenoma | | 16 |
Pars Distalis, Carcinoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| | A |
0 UG/KG | 3| 3| 3| 3| 3| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
C-Cell, Adenoma | | 7 |
C-Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 49 |
Adenoma | | 7 |
__________________________________________________________________________|____________|
Ovary | | 49 |
__________________________________________________________________________|____________|
Uterus | | 49 |
Polyp Stromal | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | | 49 |
Femoral, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Mediastinal, Leukemia Mononuclear | | 7 |
Mesenteric, Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
Leukemia Mononuclear | | 9 |
__________________________________________________________________________|____________|
Spleen | | 50 |
Leukemia Mononuclear | | 10 |
__________________________________________________________________________|____________|
Thymus | | 43 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 47 |
Adenocarcinoma | | 1 |
Fibroadenoma | | 13 |
Fibroadenoma, Multiple | | 4 |
__________________________________________________________________________|____________|
Skin | | 49 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| | A |
0 UG/KG | 3| 3| 3| 3| 3| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Carcinoma, Metastatic, Pituitary | | |
Gland | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Leukemia Mononuclear | | 9 |
__________________________________________________________________________|____________|
Nose | | 50 |
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 4 |
__________________________________________________________________________|____________|
Harderian Gland | | 49 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 50 |
Leukemia Mononuclear | | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 4| 4| 6| 7| 7| 7| 0| 7| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7|
DAY ON TEST | 8| 1| 2| 3| 2| 2| 2| 1| 5| 7| 2| 2| 2| 0| 2| 3| 5| 1| 2| 2| 2| 2| 6| 5| 2|
| 5| 8| 8| 8| 8| 8| 8| 5| 2| 4| 8| 8| 9| 5| 9| 2| 8| 6| 6| 9| 9| 9| 5| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
21 UG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Pheochromocytoma Complex | X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + M M + + M M M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X |
Pars Distalis, Carcinoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + |
C-Cell, Adenoma | X X X |
Follicular Cell, Adenoma | X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 4| 4| 6| 7| 7| 7| 0| 7| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7|
DAY ON TEST | 8| 1| 2| 3| 2| 2| 2| 1| 5| 7| 2| 2| 2| 0| 2| 3| 5| 1| 2| 2| 2| 2| 6| 5| 2|
| 5| 8| 8| 8| 8| 8| 8| 5| 2| 4| 8| 8| 9| 5| 9| 2| 8| 6| 6| 9| 9| 9| 5| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
21 UG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + |
Adenoma | X X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Polyp Stromal | X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + |
Femoral, Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + |
Mediastinal, Leukemia Mononuclear | X X |
Mesenteric, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X X|
Fibroadenoma | X X X X X X X X X |
Fibroadenoma, Multiple | X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + |
Basosquamous Tumor Benign | |
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Lipoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + |
Astrocytoma Malignant | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 4| 4| 6| 7| 7| 7| 0| 7| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7|
DAY ON TEST | 8| 1| 2| 3| 2| 2| 2| 1| 5| 7| 2| 2| 2| 0| 2| 3| 5| 1| 2| 2| 2| 2| 6| 5| 2|
| 5| 8| 8| 8| 8| 8| 8| 5| 2| 4| 8| 8| 9| 5| 9| 2| 8| 6| 6| 9| 9| 9| 5| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
21 UG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 5| 7| 4| 5| 6| 7| 6| 6|
DAY ON TEST | 3| 1| 5| 4| 3| 0| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 7| 2| 3| 4| 6|
| 0| 6| 8| 6| 0| 4| 0| 0| 0| 5| 0| 1| 1| 7| 1| 2| 6| 8| 1| 6| 7| 4| 1| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
21 UG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pheochromocytoma Complex | |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + M + M + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X|
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X X |
Follicular Cell, Adenoma | |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 5| 7| 4| 5| 6| 7| 6| 6|
DAY ON TEST | 3| 1| 5| 4| 3| 0| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 7| 2| 3| 4| 6|
| 0| 6| 8| 6| 0| 4| 0| 0| 0| 5| 0| 1| 1| 7| 1| 2| 6| 8| 1| 6| 7| 4| 1| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
21 UG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + M|
Adenoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Polyp Stromal | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + +|
Femoral, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + M + + + + +|
Mediastinal, Leukemia Mononuclear | X |
Mesenteric, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + I|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + M M + + + + + + + +|
Adenocarcinoma | |
Fibroadenoma | X X X X X X X X X X|
Fibroadenoma, Multiple | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + +|
Basosquamous Tumor Benign | X |
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | X X |
Subcutaneous Tissue, Lipoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + +|
Astrocytoma Malignant | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 5| 7| 4| 5| 6| 7| 6| 6|
DAY ON TEST | 3| 1| 5| 4| 3| 0| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 7| 2| 3| 4| 6|
| 0| 6| 8| 6| 0| 4| 0| 0| 0| 5| 0| 1| 1| 7| 1| 2| 6| 8| 1| 6| 7| 4| 1| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
21 UG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + M + + +|
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
21 UG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + |
__________________________________________________________________________|
Intestine Large | + |
__________________________________________________________________________|
Intestine Large, Cecum | + |
__________________________________________________________________________|
Intestine Large, Colon | + |
__________________________________________________________________________|
Intestine Large, Rectum | + |
__________________________________________________________________________|
Intestine Small | + |
__________________________________________________________________________|
Intestine Small, Duodenum | + |
__________________________________________________________________________|
Intestine Small, Ileum | + |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
__________________________________________________________________________|
Liver | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + |
__________________________________________________________________________|
Stomach | + |
__________________________________________________________________________|
Stomach, Forestomach | + |
__________________________________________________________________________|
Stomach, Glandular | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + |
Leukemia Mononuclear | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + |
Leukemia Mononuclear | |
Pheochromocytoma Complex | |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + |
__________________________________________________________________________|
Parathyroid Gland | M |
__________________________________________________________________________|
Pituitary Gland | + |
Leukemia Mononuclear | |
Pars Distalis, Adenoma | |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + |
C-Cell, Adenoma | |
Follicular Cell, Adenoma | |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
21 UG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Adenoma | |
__________________________________________________________________________|
Ovary | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Uterus | + |
Leukemia Mononuclear | |
Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + |
Femoral, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + |
Mediastinal, Leukemia Mononuclear | |
Mesenteric, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Thymus | + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + |
Adenocarcinoma | |
Fibroadenoma | |
Fibroadenoma, Multiple | |
__________________________________________________________________________|
Skin | + |
Basosquamous Tumor Benign | |
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Lipoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + |
Astrocytoma Malignant | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + |
Alveolar/Bronchiolar Adenoma | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
21 UG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + |
__________________________________________________________________________|
Trachea | + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Urinary Bladder | + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| | A |
21 UG/KG | 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 28 |
__________________________________________________________________________|____________|
Intestine Large | | 28 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 28 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 28 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 28 |
__________________________________________________________________________|____________|
Intestine Small | | 28 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 28 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 28 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 28 |
__________________________________________________________________________|____________|
Liver | | 29 |
Leukemia Mononuclear | | 8 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 29 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | | 28 |
__________________________________________________________________________|____________|
Stomach | | 28 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 28 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 28 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 28 |
Leukemia Mononuclear | | 1 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 29 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 29 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 27 |
Leukemia Mononuclear | | 2 |
Pheochromocytoma Complex | | 1 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 28 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 17 |
__________________________________________________________________________|____________|
Pituitary Gland | | 41 |
Leukemia Mononuclear | | 1 |
Pars Distalis, Adenoma | | 19 |
Pars Distalis, Carcinoma | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | | 32 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| | A |
21 UG/KG | 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Adenoma | | 7 |
Follicular Cell, Adenoma | | 1 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 29 |
Adenoma | | 4 |
__________________________________________________________________________|____________|
Ovary | | 29 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Uterus | | 32 |
Leukemia Mononuclear | | 1 |
Polyp Stromal | | 7 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | | 28 |
Femoral, Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Lymph Node | | 27 |
Mediastinal, Leukemia Mononuclear | | 3 |
Mesenteric, Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 26 |
Leukemia Mononuclear | | 6 |
__________________________________________________________________________|____________|
Spleen | | 29 |
Leukemia Mononuclear | | 8 |
__________________________________________________________________________|____________|
Thymus | | 27 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 40 |
Adenocarcinoma | | 2 |
Fibroadenoma | | 19 |
Fibroadenoma, Multiple | | 4 |
__________________________________________________________________________|____________|
Skin | | 31 |
Basosquamous Tumor Benign | | 1 |
Squamous Cell Papilloma | | 2 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| | A |
21 UG/KG | 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Subcutaneous Tissue, Lipoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 28 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 28 |
Astrocytoma Malignant | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 32 |
Alveolar/Bronchiolar Adenoma | | 1 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Nose | | 28 |
__________________________________________________________________________|____________|
Trachea | | 28 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | | 27 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 51 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | | 27 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 51 |
Leukemia Mononuclear | | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 5| 6| 7|
DAY ON TEST | 2| 2| 2| 2| 0| 2| 2| 2| 2| 6| 2| 6| 2| 5| 2| 2| 2| 2| 2| 2| 6| 2| 8| 9| 3|
| 8| 8| 8| 8| 6| 8| 8| 8| 8| 7| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 UG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + |
Carcinoma, Metastatic, Kidney | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Mesentery | |
Carcinoma, Metastatic, Kidney | |
__________________________________________________________________________|
Pancreas | + + + + + + + |
Carcinoma, Metastatic, Kidney | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + |
__________________________________________________________________________|
Tongue | +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + |
Medulla, Carcinoma, Metastatic, | |
Kidney | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + |
Leukemia Mononuclear | X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + |
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X|
Pars Distalis, Carcinoma | X |
Pars Intermedia, Adenoma | |
Pars Intermedia, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + |
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | X X X X |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 5| 6| 7|
DAY ON TEST | 2| 2| 2| 2| 0| 2| 2| 2| 2| 6| 2| 6| 2| 5| 2| 2| 2| 2| 2| 2| 6| 2| 8| 9| 3|
| 8| 8| 8| 8| 6| 8| 8| 8| 8| 7| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 UG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + M + + |
Adenoma | X |
Carcinoma | |
Bilateral, Adenoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + |
Carcinoma, Metastatic, Kidney | |
__________________________________________________________________________|
Uterus | + + + + + + + + + |
Leiomyosarcoma | X |
Polyp Stromal | X X |
Sarcoma Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + |
Femoral, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Thymus | + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X X |
Adenoma | X |
Fibroadenoma | X X X X X X X X X X|
Fibroadenoma, Multiple | X X |
__________________________________________________________________________|
Skin | + + + + + + + + |
Subcutaneous Tissue, Fibroma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + |
Oligodendroglioma Malignant | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 5| 6| 7|
DAY ON TEST | 2| 2| 2| 2| 0| 2| 2| 2| 2| 6| 2| 6| 2| 5| 2| 2| 2| 2| 2| 2| 6| 2| 8| 9| 3|
| 8| 8| 8| 8| 6| 8| 8| 8| 8| 7| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 UG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + |
Carcinoma, Metastatic, Kidney | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Nose | + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Renal Tubule, Adenoma | |
Renal Tubule, Carcinoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 3| 7| 7| 7| 4| 7| 6| 7| 7| 3| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 6| 3| 2| 3| 3| 7| 3| 9| 3| 3| 3| 3| 3| 3| 6| 3| 0|
| 0| 7| 0| 0| 9| 0| 0| 0| 6| 0| 2| 0| 1| 0| 1| 5| 1| 1| 1| 1| 1| 1| 4| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 UG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + +|
Carcinoma, Metastatic, Kidney | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Mesentery | + |
Carcinoma, Metastatic, Kidney | X |
__________________________________________________________________________|
Pancreas | + + + + A + + +|
Carcinoma, Metastatic, Kidney | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + +|
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + +|
Medulla, Carcinoma, Metastatic, | |
Kidney | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + +|
Leukemia Mononuclear | |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X |
Pars Distalis, Carcinoma | |
Pars Intermedia, Adenoma | X |
Pars Intermedia, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 3| 7| 7| 7| 4| 7| 6| 7| 7| 3| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 6| 3| 2| 3| 3| 7| 3| 9| 3| 3| 3| 3| 3| 3| 6| 3| 0|
| 0| 7| 0| 0| 9| 0| 0| 0| 6| 0| 2| 0| 1| 0| 1| 5| 1| 1| 1| 1| 1| 1| 4| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 UG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + M + + + + +|
Adenoma | X |
Carcinoma | X |
Bilateral, Adenoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + +|
Leiomyosarcoma | |
Polyp Stromal | |
Sarcoma Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + +|
Femoral, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Thymus | M M + + M M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + + + + + + + +|
Adenocarcinoma | |
Adenoma | |
Fibroadenoma | X X X X X X X |
Fibroadenoma, Multiple | X X X |
__________________________________________________________________________|
Skin | + + + + + + + +|
Subcutaneous Tissue, Fibroma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + +|
Oligodendroglioma Malignant | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 3| 7| 7| 7| 4| 7| 6| 7| 7| 3| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 6| 3| 2| 3| 3| 7| 3| 9| 3| 3| 3| 3| 3| 3| 6| 3| 0|
| 0| 7| 0| 0| 9| 0| 0| 0| 6| 0| 2| 0| 1| 0| 1| 5| 1| 1| 1| 1| 1| 1| 4| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 UG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Nose | + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + + + M + + +|
__________________________________________________________________________|
Zymbal's Gland | + +|
Carcinoma | X X|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Renal Tubule, Adenoma | X |
Renal Tubule, Carcinoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
70 UG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | |
__________________________________________________________________________|
Intestine Large | |
__________________________________________________________________________|
Intestine Large, Cecum | |
__________________________________________________________________________|
Intestine Large, Colon | |
__________________________________________________________________________|
Intestine Large, Rectum | |
__________________________________________________________________________|
Intestine Small | |
__________________________________________________________________________|
Intestine Small, Duodenum | |
__________________________________________________________________________|
Intestine Small, Ileum | |
__________________________________________________________________________|
Intestine Small, Jejunum | |
__________________________________________________________________________|
Liver | |
Carcinoma, Metastatic, Kidney | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Mesentery | |
Carcinoma, Metastatic, Kidney | |
__________________________________________________________________________|
Pancreas | |
Carcinoma, Metastatic, Kidney | |
__________________________________________________________________________|
Salivary Glands | |
__________________________________________________________________________|
Stomach | |
__________________________________________________________________________|
Stomach, Forestomach | |
__________________________________________________________________________|
Stomach, Glandular | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | |
__________________________________________________________________________|
Adrenal Gland, Cortex | |
Medulla, Carcinoma, Metastatic, | |
Kidney | |
__________________________________________________________________________|
Adrenal Gland, Medulla | |
Leukemia Mononuclear | |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | |
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | |
__________________________________________________________________________|
Pituitary Gland | |
Pars Distalis, Adenoma | |
Pars Distalis, Carcinoma | |
Pars Intermedia, Adenoma | |
Pars Intermedia, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | |
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
70 UG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Adenoma | |
Carcinoma | |
Bilateral, Adenoma | |
__________________________________________________________________________|
Ovary | |
Carcinoma, Metastatic, Kidney | |
__________________________________________________________________________|
Uterus | |
Leiomyosarcoma | |
Polyp Stromal | |
Sarcoma Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | |
Femoral, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Thymus | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | |
Adenocarcinoma | |
Adenoma | |
Fibroadenoma | |
Fibroadenoma, Multiple | |
__________________________________________________________________________|
Skin | |
Subcutaneous Tissue, Fibroma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | |
Oligodendroglioma Malignant | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
70 UG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | |
Carcinoma, Metastatic, Kidney | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Nose | |
__________________________________________________________________________|
Trachea | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | |
Renal Tubule, Adenoma | |
Renal Tubule, Carcinoma | |
__________________________________________________________________________|
Urinary Bladder | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| | A |
70 UG/KG | 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 15 |
__________________________________________________________________________|____________|
Intestine Large | | 15 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 14 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 15 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 14 |
__________________________________________________________________________|____________|
Intestine Small | | 15 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 14 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 14 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 15 |
__________________________________________________________________________|____________|
Liver | | 19 |
Carcinoma, Metastatic, Kidney | | 1 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
Carcinoma, Metastatic, Kidney | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 14 |
Carcinoma, Metastatic, Kidney | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | | 15 |
__________________________________________________________________________|____________|
Stomach | | 15 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 15 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 15 |
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 16 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 15 |
Medulla, Carcinoma, Metastatic, | | |
Kidney | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 15 |
Leukemia Mononuclear | | 1 |
Pheochromocytoma Benign | | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 14 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 13 |
__________________________________________________________________________|____________|
Pituitary Gland | | 35 |
Pars Distalis, Adenoma | | 15 |
Pars Distalis, Carcinoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| | A |
70 UG/KG | 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Intermedia, Adenoma | | 1 |
Pars Intermedia, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | | 18 |
Bilateral, C-Cell, Adenoma | | 1 |
C-Cell, Adenoma | | 4 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 17 |
Adenoma | | 2 |
Carcinoma | | 1 |
Bilateral, Adenoma | | 1 |
__________________________________________________________________________|____________|
Ovary | | 19 |
Carcinoma, Metastatic, Kidney | | 1 |
__________________________________________________________________________|____________|
Uterus | | 19 |
Leiomyosarcoma | | 1 |
Polyp Stromal | | 2 |
Sarcoma Stromal | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 15 |
Femoral, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 16 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 15 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Spleen | | 16 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Thymus | | 11 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 34 |
Adenocarcinoma | | 2 |
Adenoma | | 1 |
Fibroadenoma | | 17 |
Fibroadenoma, Multiple | | 5 |
__________________________________________________________________________|____________|
Skin | | 16 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 36
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| | A |
70 UG/KG | 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Subcutaneous Tissue, Fibroma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 15 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 15 |
Oligodendroglioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 18 |
Carcinoma, Metastatic, Kidney | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Nose | | 15 |
__________________________________________________________________________|____________|
Trachea | | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 5 |
__________________________________________________________________________|____________|
Harderian Gland | | 14 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Renal Tubule, Adenoma | | 1 |
Renal Tubule, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | | 15 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3|
DAY ON TEST | 2| 2| 2| 2| 2| 6| 2| 2| 1| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 3| 2| 2| 3| 0|
| 8| 8| 8| 8| 0| 8| 8| 1| 3| 8| 8| 8| 8| 0| 9| 9| 9| 9| 9| 9| 0| 9| 9| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
210 UG/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Adenoma | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + M + + + + + + + + + + + + + + M + + M M|
Adenoma | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + I + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + + M + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3|
DAY ON TEST | 2| 2| 2| 2| 2| 6| 2| 2| 1| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 3| 2| 2| 3| 0|
| 8| 8| 8| 8| 0| 8| 8| 1| 3| 8| 8| 8| 8| 0| 9| 9| 9| 9| 9| 9| 0| 9| 9| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
210 UG/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X X X X|
Polyp Stromal, Multiple | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Basosquamous Tumor | |
Malignant, Metastatic, Thymus | X|
Mediastinal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + + +|
Basosquamous Tumor Malignant | X|
Thymoma Benign | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Adenocarcinoma | |
Fibroadenoma | X X X X X X X |
Fibroadenoma, Multiple | X X X X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Basosquamous Tumor Malignant, | |
Metastatic, Thymus | X|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3|
DAY ON TEST | 2| 2| 2| 2| 2| 6| 2| 2| 1| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 3| 2| 2| 3| 0|
| 8| 8| 8| 8| 0| 8| 8| 1| 3| 8| 8| 8| 8| 0| 9| 9| 9| 9| 9| 9| 0| 9| 9| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
210 UG/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + + + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Renal Tubule, Adenoma | X X X |
Renal Tubule, Adenoma, Multiple | X X |
Renal Tubule, Carcinoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 4| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 4| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 3| 3| 4| 3| 3| 3| 3| 6| 1| 3| 3|
| 0| 0| 9| 0| 0| 6| 0| 6| 0| 0| 0| 9| 0| 1| 1| 1| 5| 1| 1| 1| 1| 0| 5| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
210 UG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Small | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Adenoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M M + + + + + M + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 4| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 4| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 3| 3| 4| 3| 3| 3| 3| 6| 1| 3| 3|
| 0| 0| 9| 0| 0| 6| 0| 6| 0| 0| 0| 9| 0| 1| 1| 1| 5| 1| 1| 1| 1| 0| 5| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
210 UG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X X |
Polyp Stromal, Multiple | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Basosquamous Tumor | |
Malignant, Metastatic, Thymus | |
Mediastinal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Thymus | + I + + M + + + + M + + + + + + + + + I + + + M +|
Basosquamous Tumor Malignant | |
Thymoma Benign | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X X |
Fibroadenoma | X X X X X X X |
Fibroadenoma, Multiple | X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibrosarcoma | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Basosquamous Tumor Malignant, | |
Metastatic, Thymus | |
Leukemia Mononuclear | X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 4| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 4| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 3| 3| 4| 3| 3| 3| 3| 6| 1| 3| 3|
| 0| 0| 9| 0| 0| 6| 0| 6| 0| 0| 0| 9| 0| 1| 1| 1| 5| 1| 1| 1| 1| 0| 5| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
210 UG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Renal Tubule, Adenoma | |
Renal Tubule, Adenoma, Multiple | |
Renal Tubule, Carcinoma | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
210 UG/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | |
__________________________________________________________________________|
Intestine Large | |
__________________________________________________________________________|
Intestine Large, Cecum | |
__________________________________________________________________________|
Intestine Large, Colon | |
__________________________________________________________________________|
Intestine Large, Rectum | |
__________________________________________________________________________|
Intestine Small | |
__________________________________________________________________________|
Intestine Small, Duodenum | |
__________________________________________________________________________|
Intestine Small, Ileum | |
__________________________________________________________________________|
Intestine Small, Jejunum | |
__________________________________________________________________________|
Liver | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | |
Acinus, Adenoma | |
__________________________________________________________________________|
Salivary Glands | |
__________________________________________________________________________|
Stomach | |
__________________________________________________________________________|
Stomach, Forestomach | |
__________________________________________________________________________|
Stomach, Glandular | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | |
__________________________________________________________________________|
Adrenal Gland, Cortex | |
Carcinoma | |
__________________________________________________________________________|
Adrenal Gland, Medulla | |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | |
__________________________________________________________________________|
Parathyroid Gland | |
Adenoma | |
__________________________________________________________________________|
Pituitary Gland | |
Pars Distalis, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | |
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Adenoma | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
210 UG/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Ovary | |
__________________________________________________________________________|
Uterus | |
Polyp Stromal | |
Polyp Stromal, Multiple | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | |
__________________________________________________________________________|
Lymph Node | |
Mediastinal, Basosquamous Tumor | |
Malignant, Metastatic, Thymus | |
Mediastinal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Thymus | |
Basosquamous Tumor Malignant | |
Thymoma Benign | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | |
Adenocarcinoma | |
Fibroadenoma | |
Fibroadenoma, Multiple | |
__________________________________________________________________________|
Skin | |
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | |
Alveolar/Bronchiolar Adenoma | |
Basosquamous Tumor Malignant, | |
Metastatic, Thymus | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Nose | |
__________________________________________________________________________|
Trachea | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
210 UG/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | |
Renal Tubule, Adenoma | |
Renal Tubule, Adenoma, Multiple | |
Renal Tubule, Carcinoma | |
__________________________________________________________________________|
Urinary Bladder | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| | T |
ANIMAL ID | 3| 3| 3| 3| 3| | A |
210 UG/ | 1| 1| 1| 1| 1| | L |
KG | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 47 |
__________________________________________________________________________|____________|
Intestine Small | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 49 |
__________________________________________________________________________|____________|
Liver | | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 50 |
Acinus, Adenoma | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach | | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 49 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Pheochromocytoma Benign | | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 42 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | | 49 |
Pars Distalis, Adenoma | | 22 |
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Bilateral, C-Cell, Adenoma | | 1 |
C-Cell, Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| | T |
ANIMAL ID | 3| 3| 3| 3| 3| | A |
210 UG/ | 1| 1| 1| 1| 1| | L |
KG | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 47 |
Adenoma | | 3 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Ovary | | 50 |
__________________________________________________________________________|____________|
Uterus | | 50 |
Polyp Stromal | | 6 |
Polyp Stromal, Multiple | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Mediastinal, Basosquamous Tumor | | |
Malignant, Metastatic, Thymus | | 1 |
Mediastinal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Spleen | | 50 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Thymus | | 44 |
Basosquamous Tumor Malignant | | 1 |
Thymoma Benign | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 49 |
Adenocarcinoma | | 2 |
Fibroadenoma | | 14 |
Fibroadenoma, Multiple | | 14 |
__________________________________________________________________________|____________|
Skin | | 50 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| | T |
ANIMAL ID | 3| 3| 3| 3| 3| | A |
210 UG/ | 1| 1| 1| 1| 1| | L |
KG | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Adenoma | | 1 |
Basosquamous Tumor Malignant, | | |
Metastatic, Thymus | | 1 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Nose | | 50 |
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 4 |
__________________________________________________________________________|____________|
Harderian Gland | | 50 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Renal Tubule, Adenoma | | 3 |
Renal Tubule, Adenoma, Multiple | | 2 |
Renal Tubule, Carcinoma | | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 50 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 49
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 0| 7| 7| 3| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 8| 2| 2| 1| 2| 2| 7| 2| 2| 2| 2| 3| 3| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3|
| 9| 9| 6| 9| 9| 0| 9| 9| 7| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 UG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma, Multiple | X |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Acinus, Adenoma | X |
Acinus, Adenoma, Multiple | |
__________________________________________________________________________|
Pharynx | + |
Palate, Squamous Cell Papilloma | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Adenoma | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Complex | X |
Pheochromocytoma Benign | X X X X X |
Bilateral, Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
Adenoma, Multiple | |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | M + M + + M + M + + + + + + + M + + + + + + + + +|
Adenoma | X|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 0| 7| 7| 3| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 8| 2| 2| 1| 2| 2| 7| 2| 2| 2| 2| 3| 3| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3|
| 9| 9| 6| 9| 9| 0| 9| 9| 7| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 UG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Adenoma | X X X X X X X|
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X X X |
Follicular Cell, Adenoma | |
Follicular Cell, Carcinoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X |
Tunic, Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deep Cervical, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X |
Mesenteric, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma | X |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + M + + + + M M +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M M + + + + + + M + + + + M + + + M + + M + +|
Fibroadenoma | X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 0| 7| 7| 3| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 8| 2| 2| 1| 2| 2| 7| 2| 2| 2| 2| 3| 3| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3|
| 9| 9| 6| 9| 9| 0| 9| 9| 7| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 UG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Keratoacanthoma | |
Squamous Cell Papilloma | X |
Trichoepithelioma | |
Sebaceous Gland, Adenoma | |
Subcutaneous Tissue, Fibroma | X X |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mixed Tumor Malignant | |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 4| 3| 9| 0| 3| 3| 1| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 1| 1| 1| 1| 6| 1| 1| 1| 0| 1| 1| 4| 1| 1| 6| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 UG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma, Multiple | |
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Acinus, Adenoma | X X |
Acinus, Adenoma, Multiple | X |
__________________________________________________________________________|
Pharynx | |
Palate, Squamous Cell Papilloma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Adenoma | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Complex | |
Pheochromocytoma Benign | X X X X X X X X|
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Adenoma, Multiple | X |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + M + M + + M M + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 4| 3| 9| 0| 3| 3| 1| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 1| 1| 1| 1| 6| 1| 1| 1| 0| 1| 1| 4| 1| 1| 6| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 UG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Adenoma | X X X X X X X |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | X X X X X |
Follicular Cell, Adenoma | X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X |
Tunic, Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deep Cervical, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X X X X X X X |
Mesenteric, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma | |
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Thymus | M M + + + + + + + + I M + + + + + M + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + M + + M + + + + M + + + + + + +|
Fibroadenoma | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + M + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 4| 3| 9| 0| 3| 3| 1| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 1| 1| 1| 1| 6| 1| 1| 1| 0| 1| 1| 4| 1| 1| 6| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 UG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Keratoacanthoma | X |
Squamous Cell Papilloma | X|
Trichoepithelioma | X |
Sebaceous Gland, Adenoma | X |
Subcutaneous Tissue, Fibroma | X X |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mixed Tumor Malignant | X |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 UG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | |
__________________________________________________________________________|
Intestine Large | |
__________________________________________________________________________|
Intestine Large, Cecum | |
__________________________________________________________________________|
Intestine Large, Colon | |
__________________________________________________________________________|
Intestine Large, Rectum | |
__________________________________________________________________________|
Intestine Small | |
__________________________________________________________________________|
Intestine Small, Duodenum | |
__________________________________________________________________________|
Intestine Small, Ileum | |
__________________________________________________________________________|
Intestine Small, Jejunum | |
__________________________________________________________________________|
Liver | |
Hepatocellular Carcinoma, Multiple | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | |
Leukemia Mononuclear | |
Acinus, Adenoma | |
Acinus, Adenoma, Multiple | |
__________________________________________________________________________|
Pharynx | |
Palate, Squamous Cell Papilloma | |
__________________________________________________________________________|
Salivary Glands | |
Acinus, Adenoma | |
__________________________________________________________________________|
Stomach | |
__________________________________________________________________________|
Stomach, Forestomach | |
__________________________________________________________________________|
Stomach, Glandular | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | |
__________________________________________________________________________|
Adrenal Gland, Cortex | |
Adenoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | |
Pheochromocytoma Complex | |
Pheochromocytoma Benign | |
Bilateral, Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | |
Adenoma | |
Adenoma, Multiple | |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | |
Adenoma | |
__________________________________________________________________________|
Pituitary Gland | |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 UG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Adenoma | |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | |
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | |
Follicular Cell, Adenoma | |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Preputial Gland | |
Adenoma | |
__________________________________________________________________________|
Prostate | |
__________________________________________________________________________|
Testes | |
Bilateral, Interstitial Cell, Adenoma| |
Interstitial Cell, Adenoma | |
Tunic, Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Bone Marrow | |
Femoral, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | |
Deep Cervical, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | |
Mesenteric, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | |
Fibrosarcoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Thymus | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | |
Fibroadenoma | |
__________________________________________________________________________|
Skin | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 UG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Keratoacanthoma | |
Squamous Cell Papilloma | |
Trichoepithelioma | |
Sebaceous Gland, Adenoma | |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | |
Astrocytoma Malignant | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Nose | |
__________________________________________________________________________|
Trachea | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | |
Leukemia Mononuclear | |
Mixed Tumor Malignant | |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | |
Serosa, Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | |
Leukemia Mononuclear | |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| | A |
0 UG/KG | 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 48 |
__________________________________________________________________________|____________|
Intestine Small | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 50 |
__________________________________________________________________________|____________|
Liver | | 50 |
Hepatocellular Carcinoma, Multiple | | 1 |
Leukemia Mononuclear | | 12 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 50 |
Leukemia Mononuclear | | 2 |
Acinus, Adenoma | | 3 |
Acinus, Adenoma, Multiple | | 1 |
__________________________________________________________________________|____________|
Pharynx | | 1 |
Palate, Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
Acinus, Adenoma | | 1 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Adenoma | | 2 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Pheochromocytoma Complex | | 1 |
Pheochromocytoma Benign | | 13 |
Bilateral, Pheochromocytoma Benign | | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
Adenoma | | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| | A |
0 UG/KG | 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Adenoma, Multiple | | 1 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 41 |
Adenoma | | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | | 50 |
Pars Distalis, Adenoma | | 14 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Bilateral, C-Cell, Adenoma | | 1 |
C-Cell, Adenoma | | 8 |
Follicular Cell, Adenoma | | 1 |
Follicular Cell, Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | | 50 |
Adenoma | | 6 |
__________________________________________________________________________|____________|
Prostate | | 50 |
__________________________________________________________________________|____________|
Testes | | 50 |
Bilateral, Interstitial Cell, Adenoma| | 39 |
Interstitial Cell, Adenoma | | 5 |
Tunic, Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Femoral, Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Deep Cervical, Leukemia Mononuclear | | 2 |
Mediastinal, Leukemia Mononuclear | | 8 |
Mesenteric, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 49 |
Leukemia Mononuclear | | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 60
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| | A |
0 UG/KG | 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | | 50 |
Fibrosarcoma | | 1 |
Leukemia Mononuclear | | 12 |
__________________________________________________________________________|____________|
Thymus | | 41 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 39 |
Fibroadenoma | | 3 |
__________________________________________________________________________|____________|
Skin | | 49 |
Keratoacanthoma | | 1 |
Squamous Cell Papilloma | | 2 |
Trichoepithelioma | | 1 |
Sebaceous Gland, Adenoma | | 1 |
Subcutaneous Tissue, Fibroma | | 4 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Astrocytoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Nose | | 50 |
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
__________________________________________________________________________|____________|
Harderian Gland | | 49 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Leukemia Mononuclear | | 1 |
Mixed Tumor Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 61
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| | A |
0 UG/KG | 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
Serosa, Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 50 |
Leukemia Mononuclear | | 12 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 62
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 6| 7| 5| 7|
DAY ON TEST | 2| 7| 2| 7| 8| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 1| 3| 8| 2| 3| 3| 7| 3| 5| 3|
| 9| 6| 9| 4| 0| 9| 9| 9| 7| 9| 0| 0| 0| 6| 8| 6| 0| 7| 2| 0| 0| 8| 1| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
21 UG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Mesentery | + + + + + |
Mesothelioma Malignant | X X X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
Acinus, Adenoma | X X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + |
__________________________________________________________________________|
Tongue | + |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + |
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X X |
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 6| 7| 5| 7|
DAY ON TEST | 2| 7| 2| 7| 8| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 1| 3| 8| 2| 3| 3| 7| 3| 5| 3|
| 9| 6| 9| 4| 0| 9| 9| 9| 7| 9| 0| 0| 0| 6| 8| 6| 0| 7| 2| 0| 0| 8| 1| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
21 UG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + |
Mesothelioma Malignant | X X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + |
Adenoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Benign | X |
Mesothelioma Malignant | X X X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + |
Femoral, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + |
Mediastinal, Leukemia Mononuclear | X X |
Mediastinal, Sarcoma, Metastatic, | |
Uncertain Primary Site | |
Mesenteric, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Thymus | + + + + + M + + M M + M |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + M + + +|
Fibroadenoma | X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + |
Basosquamous Tumor Benign | X |
Keratoacanthoma | X |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 6| 7| 5| 7|
DAY ON TEST | 2| 7| 2| 7| 8| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 1| 3| 8| 2| 3| 3| 7| 3| 5| 3|
| 9| 6| 9| 4| 0| 9| 9| 9| 7| 9| 0| 0| 0| 6| 8| 6| 0| 7| 2| 0| 0| 8| 1| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
21 UG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Sebaceous Gland, Adenoma | |
Subcutaneous Tissue, Fibroma | X X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
Diaphragm, Sarcoma, Metastatic, | |
Uncertain Primary Site | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Leukemia Mononuclear | X X |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + A + + + + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Mesothelioma Benign | X |
Mesothelioma Malignant | X X X X |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 6| 5| 7| 6| 7| 4| 7| 6| 2| 7| 6| 7| 4| 6| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 1| 3| 3| 3| 2| 5| 3| 7| 3| 1| 3| 3| 6| 1| 2| 3| 0| 8| 3| 3| 8| 3| 0|
| 1| 1| 7| 1| 1| 1| 8| 6| 2| 5| 2| 8| 2| 3| 2| 7| 4| 2| 9| 1| 2| 2| 8| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
21 UG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Mesentery | + + |
Mesothelioma Malignant | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
Acinus, Adenoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + |
__________________________________________________________________________|
Tongue | + + |
Squamous Cell Papilloma | X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + +|
Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + +|
Adenoma | X X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M A + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X|
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + A + + + + +|
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 6| 5| 7| 6| 7| 4| 7| 6| 2| 7| 6| 7| 4| 6| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 1| 3| 3| 3| 2| 5| 3| 7| 3| 1| 3| 3| 6| 1| 2| 3| 0| 8| 3| 3| 8| 3| 0|
| 1| 1| 7| 1| 1| 1| 8| 6| 2| 5| 2| 8| 2| 3| 2| 7| 4| 2| 9| 1| 2| 2| 8| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
21 UG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + +|
Mesothelioma Malignant | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + +|
Adenoma | X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Benign | |
Mesothelioma Malignant | |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + A + + + + + + + +|
Femoral, Leukemia Mononuclear | X X|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + +|
Mediastinal, Leukemia Mononuclear | X |
Mediastinal, Sarcoma, Metastatic, | |
Uncertain Primary Site | X |
Mesenteric, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + M M + + + + M +|
Fibroadenoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + +|
Basosquamous Tumor Benign | |
Keratoacanthoma | |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 6| 5| 7| 6| 7| 4| 7| 6| 2| 7| 6| 7| 4| 6| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 1| 3| 3| 3| 2| 5| 3| 7| 3| 1| 3| 3| 6| 1| 2| 3| 0| 8| 3| 3| 8| 3| 0|
| 1| 1| 7| 1| 1| 1| 8| 6| 2| 5| 2| 8| 2| 3| 2| 7| 4| 2| 9| 1| 2| 2| 8| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
21 UG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Sebaceous Gland, Adenoma | X |
Subcutaneous Tissue, Fibroma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Diaphragm, Sarcoma, Metastatic, | |
Uncertain Primary Site | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + A + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | |
Leukemia Mononuclear | X X X X|
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + A +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + + + + + M + + M M M +|
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + A + + M + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
Mesothelioma Benign | |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
21 UG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + |
__________________________________________________________________________|
Intestine Large | + |
__________________________________________________________________________|
Intestine Large, Cecum | + |
__________________________________________________________________________|
Intestine Large, Colon | + |
__________________________________________________________________________|
Intestine Large, Rectum | + |
__________________________________________________________________________|
Intestine Small | + |
__________________________________________________________________________|
Intestine Small, Duodenum | + |
__________________________________________________________________________|
Intestine Small, Ileum | + |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
__________________________________________________________________________|
Liver | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Mesentery | |
Mesothelioma Malignant | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Pancreas | + |
Leukemia Mononuclear | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
Acinus, Adenoma | |
__________________________________________________________________________|
Salivary Glands | + |
__________________________________________________________________________|
Stomach | + |
__________________________________________________________________________|
Stomach, Forestomach | + |
__________________________________________________________________________|
Stomach, Glandular | + |
__________________________________________________________________________|
Tongue | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + |
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | M |
__________________________________________________________________________|
Pituitary Gland | + |
Leukemia Mononuclear | |
Pars Distalis, Adenoma | |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
21 UG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Adenoma | |
C-Cell, Carcinoma | |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + |
Mesothelioma Malignant | |
__________________________________________________________________________|
Preputial Gland | + |
Adenoma | |
__________________________________________________________________________|
Prostate | + |
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + |
Mesothelioma Benign | |
Mesothelioma Malignant | |
Bilateral, Interstitial Cell, Adenoma| |
Interstitial Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + |
Femoral, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + |
Mediastinal, Leukemia Mononuclear | |
Mediastinal, Sarcoma, Metastatic, | |
Uncertain Primary Site | |
Mesenteric, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Thymus | + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + |
Fibroadenoma | |
__________________________________________________________________________|
Skin | + |
Basosquamous Tumor Benign | |
Keratoacanthoma | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
21 UG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Sebaceous Gland, Adenoma | |
Subcutaneous Tissue, Fibroma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + |
__________________________________________________________________________|
Skeletal Muscle | |
Diaphragm, Sarcoma, Metastatic, | |
Uncertain Primary Site | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + |
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | |
Leukemia Mononuclear | |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
__________________________________________________________________________|
Nose | + |
__________________________________________________________________________|
Trachea | + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + |
Leukemia Mononuclear | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + |
Leukemia Mononuclear | |
Mesothelioma Benign | |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| | A |
21 UG/KG | 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 26 |
__________________________________________________________________________|____________|
Intestine Large | | 26 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 23 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 25 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 23 |
__________________________________________________________________________|____________|
Intestine Small | | 26 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 25 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 24 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 25 |
__________________________________________________________________________|____________|
Liver | | 26 |
Leukemia Mononuclear | | 6 |
__________________________________________________________________________|____________|
Mesentery | | 7 |
Mesothelioma Malignant | | 3 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 26 |
Leukemia Mononuclear | | 2 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
Acinus, Adenoma | | 3 |
__________________________________________________________________________|____________|
Salivary Glands | | 26 |
__________________________________________________________________________|____________|
Stomach | | 26 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 25 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 25 |
__________________________________________________________________________|____________|
Tongue | | 3 |
Squamous Cell Papilloma | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 26 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 25 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 25 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 25 |
Pheochromocytoma Benign | | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 26 |
Adenoma | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 21 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 72
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| | A |
21 UG/KG | 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | | 33 |
Leukemia Mononuclear | | 1 |
Pars Distalis, Adenoma | | 16 |
Pars Distalis, Carcinoma | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | | 29 |
C-Cell, Adenoma | | 5 |
C-Cell, Carcinoma | | 1 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 26 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________|____________|
Preputial Gland | | 28 |
Adenoma | | 3 |
__________________________________________________________________________|____________|
Prostate | | 26 |
__________________________________________________________________________|____________|
Seminal Vesicle | | 1 |
__________________________________________________________________________|____________|
Testes | | 50 |
Mesothelioma Benign | | 1 |
Mesothelioma Malignant | | 3 |
Bilateral, Interstitial Cell, Adenoma| | 34 |
Interstitial Cell, Adenoma | | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 25 |
Femoral, Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Lymph Node | | 28 |
Mediastinal, Leukemia Mononuclear | | 3 |
Mediastinal, Sarcoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Mesenteric, Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 28 |
Leukemia Mononuclear | | 6 |
__________________________________________________________________________|____________|
Spleen | | 29 |
Leukemia Mononuclear | | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 73
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| | A |
21 UG/KG | 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | | 22 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 22 |
Fibroadenoma | | 2 |
__________________________________________________________________________|____________|
Skin | | 32 |
Basosquamous Tumor Benign | | 1 |
Keratoacanthoma | | 1 |
Squamous Cell Papilloma | | 1 |
Sebaceous Gland, Adenoma | | 1 |
Subcutaneous Tissue, Fibroma | | 4 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 26 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Diaphragm, Sarcoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 25 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 30 |
Alveolar/Bronchiolar Adenoma | | 3 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Leukemia Mononuclear | | 6 |
Mediastinum, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
__________________________________________________________________________|____________|
Nose | | 25 |
__________________________________________________________________________|____________|
Trachea | | 26 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 22 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 74
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| | A |
21 UG/KG | 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | | 51 |
Leukemia Mononuclear | | 3 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
Renal Tubule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Urethra | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | | 23 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 51 |
Leukemia Mononuclear | | 7 |
Mesothelioma Benign | | 1 |
Mesothelioma Malignant | | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 75
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 5| 0| 2| 2| 2| 2| 2| 5| 4| 8| 3| 3| 3| 3| 1| 0| 3| 3| 1| 1| 3|
| 9| 9| 4| 9| 9| 6| 0| 9| 9| 9| 9| 4| 6| 1| 0| 0| 0| 0| 6| 7| 0| 0| 2| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
70 UG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | A + + A + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Mesentery | + + |
Carcinoma, Metastatic, Kidney | X |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + |
Carcinoma, Metastatic, Kidney | X X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + |
__________________________________________________________________________|
Tongue | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + |
Atrium, Sarcoma, Metastatic, | |
Uncertain Primary Site | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | M + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + |
Leukemia Mononuclear | |
Pheochromocytoma Malignant | X X |
Pheochromocytoma Complex | X |
Pheochromocytoma Benign | X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + + + + + + + |
Adenoma | X X |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + |
Pars Distalis, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 5| 0| 2| 2| 2| 2| 2| 5| 4| 8| 3| 3| 3| 3| 1| 0| 3| 3| 1| 1| 3|
| 9| 9| 4| 9| 9| 6| 0| 9| 9| 9| 9| 4| 6| 1| 0| 0| 0| 0| 6| 7| 0| 0| 2| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
70 UG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + A + + + + + + + + |
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + |
Adenoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + |
Femoral, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + |
Mediastinal, Carcinoma, Metastatic, | |
Kidney | X |
Mediastinal, Leukemia Mononuclear | |
Mediastinal, Squamous Cell Carcinoma,| |
Metastatic, Lung | X |
Mesenteric, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | |
Renal, Mediastinal, Pancreatic, | |
Carcinoma, Metastatic, Kidney | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + |
Carcinoma, Metastatic, Kidney | X |
Fibrosarcoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Thymus | + M + M + M + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + |
Adenoma | X |
Fibroadenoma | X |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 5| 0| 2| 2| 2| 2| 2| 5| 4| 8| 3| 3| 3| 3| 1| 0| 3| 3| 1| 1| 3|
| 9| 9| 4| 9| 9| 6| 0| 9| 9| 9| 9| 4| 6| 1| 0| 0| 0| 0| 6| 7| 0| 0| 2| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
70 UG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + |
Basosquamous Tumor Benign | |
Keratoacanthoma | X |
Squamous Cell Papilloma | X |
Sebaceous Gland, Adenoma | X |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + |
Astrocytoma Malignant | |
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + |
Carcinoma, Metastatic, Kidney | X X |
Leukemia Mononuclear | |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | X X |
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + + + + + M + + M + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Bilateral, Renal Tubule, Carcinoma | |
Renal Tubule, Adenoma | X X |
Renal Tubule, Carcinoma | X X X X X X X |
Renal Tubule, Carcinoma, Multiple | X X |
Renal Tubule, Epithelium, Adenoma | X |
Renal Tubule, Epithelium, Adenoma, | |
Multiple | X |
__________________________________________________________________________|
Urinary Bladder | + + + A + + + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 5| 0| 2| 2| 2| 2| 2| 5| 4| 8| 3| 3| 3| 3| 1| 0| 3| 3| 1| 1| 3|
| 9| 9| 4| 9| 9| 6| 0| 9| 9| 9| 9| 4| 6| 1| 0| 0| 0| 0| 6| 7| 0| 0| 2| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
70 UG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 2| 6| 7| 6| 7| 2| 7| 7| 7| 7| 5|
DAY ON TEST | 6| 3| 3| 0| 3| 3| 4| 7| 3| 3| 3| 6| 3| 4| 9| 9| 1| 7| 3| 9| 3| 3| 3| 1| 8|
| 1| 1| 1| 9| 1| 1| 4| 2| 1| 2| 2| 9| 2| 0| 7| 1| 6| 4| 2| 0| 2| 2| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
70 UG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Mesentery | + + + |
Carcinoma, Metastatic, Kidney | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | X X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + +|
Squamous Cell Papilloma | X X|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + +|
Atrium, Sarcoma, Metastatic, | |
Uncertain Primary Site | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Pheochromocytoma Malignant | |
Pheochromocytoma Complex | |
Pheochromocytoma Benign | X X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + M + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + I + + + + + + +|
Pars Distalis, Adenoma | X X X X |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 2| 6| 7| 6| 7| 2| 7| 7| 7| 7| 5|
DAY ON TEST | 6| 3| 3| 0| 3| 3| 4| 7| 3| 3| 3| 6| 3| 4| 9| 9| 1| 7| 3| 9| 3| 3| 3| 1| 8|
| 1| 1| 1| 9| 1| 1| 4| 2| 1| 2| 2| 9| 2| 0| 7| 1| 6| 4| 2| 0| 2| 2| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
70 UG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Carcinoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + +|
Femoral, Leukemia Mononuclear | X X X|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + +|
Mediastinal, Carcinoma, Metastatic, | |
Kidney | X |
Mediastinal, Leukemia Mononuclear | X X X X|
Mediastinal, Squamous Cell Carcinoma,| |
Metastatic, Lung | |
Mesenteric, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X X|
Renal, Mediastinal, Pancreatic, | |
Carcinoma, Metastatic, Kidney | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Spleen | + + + + + A + + + + + + + +|
Carcinoma, Metastatic, Kidney | |
Fibrosarcoma | X |
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + M + + + + + + + +|
Adenoma | |
Fibroadenoma | |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 2| 6| 7| 6| 7| 2| 7| 7| 7| 7| 5|
DAY ON TEST | 6| 3| 3| 0| 3| 3| 4| 7| 3| 3| 3| 6| 3| 4| 9| 9| 1| 7| 3| 9| 3| 3| 3| 1| 8|
| 1| 1| 1| 9| 1| 1| 4| 2| 1| 2| 2| 9| 2| 0| 7| 1| 6| 4| 2| 0| 2| 2| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
70 UG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + I + + + + + + + +|
Basosquamous Tumor Benign | X |
Keratoacanthoma | X X X|
Squamous Cell Papilloma | X X X|
Sebaceous Gland, Adenoma | |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | X X |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + +|
Astrocytoma Malignant | X |
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | X |
Leukemia Mononuclear | X X X X|
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + + + + M + M + + + M +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
Bilateral, Renal Tubule, Carcinoma | X |
Renal Tubule, Adenoma | X |
Renal Tubule, Carcinoma | X X X X X |
Renal Tubule, Carcinoma, Multiple | X |
Renal Tubule, Epithelium, Adenoma | X |
Renal Tubule, Epithelium, Adenoma, | |
Multiple | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 2| 6| 7| 6| 7| 2| 7| 7| 7| 7| 5|
DAY ON TEST | 6| 3| 3| 0| 3| 3| 4| 7| 3| 3| 3| 6| 3| 4| 9| 9| 1| 7| 3| 9| 3| 3| 3| 1| 8|
| 1| 1| 1| 9| 1| 1| 4| 2| 1| 2| 2| 9| 2| 0| 7| 1| 6| 4| 2| 0| 2| 2| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
70 UG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Leukemia Mononuclear | X X X X X|
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
70 UG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + |
__________________________________________________________________________|
Intestine Large | + |
__________________________________________________________________________|
Intestine Large, Cecum | A |
__________________________________________________________________________|
Intestine Large, Colon | + |
__________________________________________________________________________|
Intestine Large, Rectum | + |
__________________________________________________________________________|
Intestine Small | + |
__________________________________________________________________________|
Intestine Small, Duodenum | A |
__________________________________________________________________________|
Intestine Small, Ileum | A |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
__________________________________________________________________________|
Liver | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Mesentery | |
Carcinoma, Metastatic, Kidney | |
__________________________________________________________________________|
Pancreas | + |
Carcinoma, Metastatic, Kidney | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + |
__________________________________________________________________________|
Stomach | + |
__________________________________________________________________________|
Stomach, Forestomach | + |
__________________________________________________________________________|
Stomach, Glandular | + |
__________________________________________________________________________|
Tongue | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + |
Atrium, Sarcoma, Metastatic, | |
Uncertain Primary Site | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + |
Leukemia Mononuclear | |
Pheochromocytoma Malignant | |
Pheochromocytoma Complex | |
Pheochromocytoma Benign | |
Bilateral, Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + |
Adenoma | |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + |
__________________________________________________________________________|
Pituitary Gland | + |
Pars Distalis, Adenoma | |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
70 UG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + |
C-Cell, Adenoma | |
C-Cell, Carcinoma | |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + |
__________________________________________________________________________|
Preputial Gland | + |
Adenoma | |
__________________________________________________________________________|
Prostate | + |
__________________________________________________________________________|
Testes | + |
Bilateral, Interstitial Cell, Adenoma| |
Interstitial Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + |
Femoral, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + |
Mediastinal, Carcinoma, Metastatic, | |
Kidney | |
Mediastinal, Leukemia Mononuclear | |
Mediastinal, Squamous Cell Carcinoma,| |
Metastatic, Lung | |
Mesenteric, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | |
Renal, Mediastinal, Pancreatic, | |
Carcinoma, Metastatic, Kidney | |
__________________________________________________________________________|
Lymph Node, Mandibular | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + |
Carcinoma, Metastatic, Kidney | |
Fibrosarcoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Thymus | + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + |
Adenoma | |
Fibroadenoma | |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
70 UG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + |
Basosquamous Tumor Benign | |
Keratoacanthoma | |
Squamous Cell Papilloma | |
Sebaceous Gland, Adenoma | |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + |
Astrocytoma Malignant | |
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + |
Carcinoma, Metastatic, Kidney | |
Leukemia Mononuclear | |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Nose | + |
__________________________________________________________________________|
Trachea | + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | M |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + |
Leukemia Mononuclear | |
Bilateral, Renal Tubule, Carcinoma | |
Renal Tubule, Adenoma | |
Renal Tubule, Carcinoma | |
Renal Tubule, Carcinoma, Multiple | |
Renal Tubule, Epithelium, Adenoma | |
Renal Tubule, Epithelium, Adenoma, | |
Multiple | |
__________________________________________________________________________|
Urinary Bladder | + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
70 UG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| | A |
70 UG/KG | 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 25 |
__________________________________________________________________________|____________|
Intestine Large | | 25 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 20 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 24 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 24 |
__________________________________________________________________________|____________|
Intestine Small | | 25 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 23 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 21 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 22 |
__________________________________________________________________________|____________|
Liver | | 26 |
Leukemia Mononuclear | | 6 |
__________________________________________________________________________|____________|
Mesentery | | 5 |
Carcinoma, Metastatic, Kidney | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 24 |
Carcinoma, Metastatic, Kidney | | 4 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | | 25 |
__________________________________________________________________________|____________|
Stomach | | 25 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 25 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 25 |
__________________________________________________________________________|____________|
Tongue | | 2 |
Squamous Cell Papilloma | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 25 |
Atrium, Sarcoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 28 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 25 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 26 |
Leukemia Mononuclear | | 4 |
Pheochromocytoma Malignant | | 2 |
Pheochromocytoma Complex | | 1 |
Pheochromocytoma Benign | | 3 |
Bilateral, Pheochromocytoma Benign | | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 26 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 88
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| | A |
70 UG/KG | 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Adenoma | | 3 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 21 |
__________________________________________________________________________|____________|
Pituitary Gland | | 27 |
Pars Distalis, Adenoma | | 7 |
Pars Distalis, Carcinoma | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | | 26 |
C-Cell, Adenoma | | 6 |
C-Cell, Carcinoma | | 1 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 25 |
__________________________________________________________________________|____________|
Preputial Gland | | 25 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Prostate | | 25 |
__________________________________________________________________________|____________|
Testes | | 48 |
Bilateral, Interstitial Cell, Adenoma| | 32 |
Interstitial Cell, Adenoma | | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 25 |
Femoral, Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Lymph Node | | 25 |
Mediastinal, Carcinoma, Metastatic, | | |
Kidney | | 2 |
Mediastinal, Leukemia Mononuclear | | 4 |
Mediastinal, Squamous Cell Carcinoma,| | |
Metastatic, Lung | | 1 |
Mesenteric, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | | 2 |
Renal, Mediastinal, Pancreatic, | | |
Carcinoma, Metastatic, Kidney | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 23 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 89
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| | A |
70 UG/KG | 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | | 27 |
Carcinoma, Metastatic, Kidney | | 1 |
Fibrosarcoma | | 1 |
Leukemia Mononuclear | | 6 |
__________________________________________________________________________|____________|
Thymus | | 20 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 23 |
Adenoma | | 1 |
Fibroadenoma | | 1 |
__________________________________________________________________________|____________|
Skin | | 30 |
Basosquamous Tumor Benign | | 1 |
Keratoacanthoma | | 4 |
Squamous Cell Papilloma | | 4 |
Sebaceous Gland, Adenoma | | 1 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 2 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 25 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 25 |
Astrocytoma Malignant | | 1 |
Osteosarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 27 |
Carcinoma, Metastatic, Kidney | | 3 |
Leukemia Mononuclear | | 4 |
Pheochromocytoma Malignant, | | |
Metastatic, Adrenal Gland | | 2 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Nose | | 24 |
__________________________________________________________________________|____________|
Trachea | | 25 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 90
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| | A |
70 UG/KG | 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | | 4 |
__________________________________________________________________________|____________|
Harderian Gland | | 19 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 51 |
Leukemia Mononuclear | | 4 |
Bilateral, Renal Tubule, Carcinoma | | 1 |
Renal Tubule, Adenoma | | 3 |
Renal Tubule, Carcinoma | | 12 |
Renal Tubule, Carcinoma, Multiple | | 3 |
Renal Tubule, Epithelium, Adenoma | | 2 |
Renal Tubule, Epithelium, Adenoma, | | |
Multiple | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | | 24 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 51 |
Leukemia Mononuclear | | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 91
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 5| 4| 7| 6| 6| 7| 7| 6| 4| 5| 6| 6| 5| 7| 7| 5| 7| 7| 7| 3| 4|
DAY ON TEST | 2| 2| 1| 2| 1| 1| 2| 3| 4| 2| 2| 9| 0| 4| 4| 8| 8| 2| 3| 4| 3| 3| 3| 9| 3|
| 9| 9| 3| 5| 3| 5| 9| 8| 7| 9| 9| 0| 0| 0| 9| 4| 9| 9| 0| 0| 0| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
210 UG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + M + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | X X|
Hepatocellular Carcinoma | X |
Leukemia Mononuclear | X X X X |
Neoplastic Nodule | |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Carcinoma, Metastatic, Kidney | X X X X X X|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | X X X |
Leukemia Mononuclear | X |
Acinus, Adenoma | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | X X|
Epicardium, Carcinoma, Metastatic, | |
Kidney | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Medulla, Carcinoma, Metastatic, | |
Kidney | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | |
Pheochromocytoma Complex | X |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 5| 4| 7| 6| 6| 7| 7| 6| 4| 5| 6| 6| 5| 7| 7| 5| 7| 7| 7| 3| 4|
DAY ON TEST | 2| 2| 1| 2| 1| 1| 2| 3| 4| 2| 2| 9| 0| 4| 4| 8| 8| 2| 3| 4| 3| 3| 3| 9| 3|
| 9| 9| 3| 5| 3| 5| 9| 8| 7| 9| 9| 0| 0| 0| 9| 4| 9| 9| 0| 0| 0| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
210 UG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Benign | X X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | X |
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | X |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X X X |
Tunic, Carcinoma, Metastatic, Kidney | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Leukemia Mononuclear | X |
Lumbar, Leukemia Mononuclear | |
Mediastinal, Carcinoma, Metastatic, | |
Kidney | X X X X|
Mediastinal, Leukemia Mononuclear | X X |
Pancreatic, Adenocarcinoma, | |
Metastatic, Stomach | X |
Renal, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 5| 4| 7| 6| 6| 7| 7| 6| 4| 5| 6| 6| 5| 7| 7| 5| 7| 7| 7| 3| 4|
DAY ON TEST | 2| 2| 1| 2| 1| 1| 2| 3| 4| 2| 2| 9| 0| 4| 4| 8| 8| 2| 3| 4| 3| 3| 3| 9| 3|
| 9| 9| 3| 5| 3| 5| 9| 8| 7| 9| 9| 0| 0| 0| 9| 4| 9| 9| 0| 0| 0| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
210 UG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Mediastinal, Pancreatic, | |
Carcinoma, Metastatic, Kidney | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | X |
Carcinoma, Metastatic, Zymbal's Gland| X |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | X |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Thymus | + + + + + M + + + + M + + + + M + + + + + + + +|
Carcinoma, Metastatic, Kidney | X |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + + + + M + + + M + + M|
Fibroadenoma | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Squamous Cell Papilloma | |
Sebaceous Gland, Adenoma | X |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Lipoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | X X X X X X X|
Carcinoma, Metastatic, Uncertain | |
Primary Site | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + + M + + + + + + + + M M + + + + + + + + + M M|
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 5| 4| 7| 6| 6| 7| 7| 6| 4| 5| 6| 6| 5| 7| 7| 5| 7| 7| 7| 3| 4|
DAY ON TEST | 2| 2| 1| 2| 1| 1| 2| 3| 4| 2| 2| 9| 0| 4| 4| 8| 8| 2| 3| 4| 3| 3| 3| 9| 3|
| 9| 9| 3| 5| 3| 5| 9| 8| 7| 9| 9| 0| 0| 0| 9| 4| 9| 9| 0| 0| 0| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
210 UG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Carcinoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Bilateral, Renal Tubule, Carcinoma | X |
Bilateral, Renal Tubule, Carcinoma, | |
Multiple | |
Capsule, Carcinoma, Metastatic, | |
Kidney | X |
Lymphatic, Carcinoma, Metastatic, | |
Kidney | X |
Renal Tubule, Adenoma | X X X X |
Renal Tubule, Carcinoma | X X X X X X X X X|
Renal Tubule, Carcinoma, Multiple | X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 4| 7| 6| 5| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 4| 3| 3| 3| 4| 0| 2| 4| 0| 4| 6| 6| 0| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 4| 3|
| 4| 0| 0| 1| 0| 8| 3| 7| 6| 7| 1| 9| 2| 1| 1| 1| 1| 1| 2| 2| 7| 2| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
210 UG/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | |
Hepatocellular Carcinoma | |
Leukemia Mononuclear | X X X |
Neoplastic Nodule | X |
__________________________________________________________________________|
Mesentery | + + + + |
Carcinoma, Metastatic, Kidney | X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | |
Leukemia Mononuclear | X |
Acinus, Adenoma | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
__________________________________________________________________________|
Tongue | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | |
Epicardium, Carcinoma, Metastatic, | |
Kidney | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Medulla, Carcinoma, Metastatic, | |
Kidney | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | X |
Pheochromocytoma Complex | |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 4| 7| 6| 5| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 4| 3| 3| 3| 4| 0| 2| 4| 0| 4| 6| 6| 0| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 4| 3|
| 4| 0| 0| 1| 0| 8| 3| 7| 6| 7| 1| 9| 2| 1| 1| 1| 1| 1| 2| 2| 7| 2| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
210 UG/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Benign | X X X X X X X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + M + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | X |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Sarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X X X |
Tunic, Carcinoma, Metastatic, Kidney | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Leukemia Mononuclear | |
Lumbar, Leukemia Mononuclear | X |
Mediastinal, Carcinoma, Metastatic, | |
Kidney | X X X |
Mediastinal, Leukemia Mononuclear | X X X |
Pancreatic, Adenocarcinoma, | |
Metastatic, Stomach | |
Renal, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 4| 7| 6| 5| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 4| 3| 3| 3| 4| 0| 2| 4| 0| 4| 6| 6| 0| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 4| 3|
| 4| 0| 0| 1| 0| 8| 3| 7| 6| 7| 1| 9| 2| 1| 1| 1| 1| 1| 2| 2| 7| 2| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
210 UG/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Mediastinal, Pancreatic, | |
Carcinoma, Metastatic, Kidney | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | |
Carcinoma, Metastatic, Zymbal's Gland| |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | X |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Thymus | + + + + + M M + + + + + M M + + + M M M + + + +|
Carcinoma, Metastatic, Kidney | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + M + + + + + + M M M + + + + + M +|
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + M + + + + + + + +|
Keratoacanthoma | X |
Squamous Cell Papilloma | X |
Sebaceous Gland, Adenoma | |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Lipoma | X|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteosarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | X X X X X X |
Carcinoma, Metastatic, Uncertain | |
Primary Site | X |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + + + + M + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 4| 7| 6| 5| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 4| 3| 3| 3| 4| 0| 2| 4| 0| 4| 6| 6| 0| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 4| 3|
| 4| 0| 0| 1| 0| 8| 3| 7| 6| 7| 1| 9| 2| 1| 1| 1| 1| 1| 2| 2| 7| 2| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
210 UG/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Bilateral, Renal Tubule, Carcinoma | X X |
Bilateral, Renal Tubule, Carcinoma, | |
Multiple | X |
Capsule, Carcinoma, Metastatic, | |
Kidney | |
Lymphatic, Carcinoma, Metastatic, | |
Kidney | |
Renal Tubule, Adenoma | X X X X X X |
Renal Tubule, Carcinoma | X X X X X X X X X X X|
Renal Tubule, Carcinoma, Multiple | X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
Page 99
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
210 UG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | |
__________________________________________________________________________|
Intestine Large | |
__________________________________________________________________________|
Intestine Large, Cecum | |
__________________________________________________________________________|
Intestine Large, Colon | |
__________________________________________________________________________|
Intestine Large, Rectum | |
__________________________________________________________________________|
Intestine Small | |
__________________________________________________________________________|
Intestine Small, Duodenum | |
__________________________________________________________________________|
Intestine Small, Ileum | |
Adenocarcinoma | |
__________________________________________________________________________|
Intestine Small, Jejunum | |
__________________________________________________________________________|
Liver | |
Carcinoma, Metastatic, Kidney | |
Hepatocellular Carcinoma | |
Leukemia Mononuclear | |
Neoplastic Nodule | |
__________________________________________________________________________|
Mesentery | |
Carcinoma, Metastatic, Kidney | |
__________________________________________________________________________|
Pancreas | |
Carcinoma, Metastatic, Kidney | |
Leukemia Mononuclear | |
Acinus, Adenoma | |
__________________________________________________________________________|
Salivary Glands | |
__________________________________________________________________________|
Stomach | |
__________________________________________________________________________|
Stomach, Forestomach | |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | |
Adenocarcinoma | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | |
Carcinoma, Metastatic, Kidney | |
Epicardium, Carcinoma, Metastatic, | |
Kidney | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | |
__________________________________________________________________________|
Adrenal Gland, Cortex | |
Leukemia Mononuclear | |
Medulla, Carcinoma, Metastatic, | |
Kidney | |
__________________________________________________________________________|
Adrenal Gland, Medulla | |
Pheochromocytoma Malignant | |
Pheochromocytoma Complex | |
_____________________________________________________________________________________________________________________|
Page 100
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
210 UG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Benign | |
Bilateral, Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | |
Adenoma | |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | |
__________________________________________________________________________|
Pituitary Gland | |
Pars Distalis, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | |
Carcinoma, Metastatic, Kidney | |
C-Cell, Adenoma | |
C-Cell, Carcinoma | |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | |
Carcinoma, Metastatic, Kidney | |
__________________________________________________________________________|
Preputial Gland | |
Adenoma | |
__________________________________________________________________________|
Prostate | |
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | |
Bilateral, Interstitial Cell, Adenoma| |
Interstitial Cell, Adenoma | |
Tunic, Carcinoma, Metastatic, Kidney | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Bone Marrow | |
Femoral, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | |
Inguinal, Leukemia Mononuclear | |
Lumbar, Leukemia Mononuclear | |
Mediastinal, Carcinoma, Metastatic, | |
Kidney | |
Mediastinal, Leukemia Mononuclear | |
Pancreatic, Adenocarcinoma, | |
Metastatic, Stomach | |
Renal, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 101
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
210 UG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Mediastinal, Pancreatic, | |
Carcinoma, Metastatic, Kidney | |
__________________________________________________________________________|
Lymph Node, Mandibular | |
Carcinoma, Metastatic, Kidney | |
Carcinoma, Metastatic, Zymbal's Gland| |
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | |
Carcinoma, Metastatic, Kidney | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Thymus | |
Carcinoma, Metastatic, Kidney | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | |
Fibroadenoma | |
__________________________________________________________________________|
Skin | |
Keratoacanthoma | |
Squamous Cell Papilloma | |
Sebaceous Gland, Adenoma | |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Lipoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
Cranium, Osteosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | |
Carcinoma, Metastatic, Kidney | |
Carcinoma, Metastatic, Uncertain | |
Primary Site | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Nose | |
__________________________________________________________________________|
Trachea | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
Page 102
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
210 UG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | |
Leukemia Mononuclear | |
Bilateral, Renal Tubule, Carcinoma | |
Bilateral, Renal Tubule, Carcinoma, | |
Multiple | |
Capsule, Carcinoma, Metastatic, | |
Kidney | |
Lymphatic, Carcinoma, Metastatic, | |
Kidney | |
Renal Tubule, Adenoma | |
Renal Tubule, Carcinoma | |
Renal Tubule, Carcinoma, Multiple | |
__________________________________________________________________________|
Urinary Bladder | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 103
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| | A |
210 UG/ | 4| 4| 4| 4| 4| | L |
KG | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 47 |
__________________________________________________________________________|____________|
Intestine Small | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 50 |
Adenocarcinoma | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 50 |
__________________________________________________________________________|____________|
Liver | | 50 |
Carcinoma, Metastatic, Kidney | | 2 |
Hepatocellular Carcinoma | | 1 |
Leukemia Mononuclear | | 7 |
Neoplastic Nodule | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 11 |
Carcinoma, Metastatic, Kidney | | 8 |
__________________________________________________________________________|____________|
Pancreas | | 50 |
Carcinoma, Metastatic, Kidney | | 3 |
Leukemia Mononuclear | | 2 |
Acinus, Adenoma | | 3 |
__________________________________________________________________________|____________|
Salivary Glands | | 49 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 49 |
Adenocarcinoma | | 1 |
__________________________________________________________________________|____________|
Tongue | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Carcinoma, Metastatic, Kidney | | 2 |
Epicardium, Carcinoma, Metastatic, | | |
Kidney | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 104
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| | A |
210 UG/ | 4| 4| 4| 4| 4| | L |
KG | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Medulla, Carcinoma, Metastatic, | | |
Kidney | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 49 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Complex | | 1 |
Pheochromocytoma Benign | | 9 |
Bilateral, Pheochromocytoma Benign | | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
Adenoma | | 1 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 47 |
__________________________________________________________________________|____________|
Pituitary Gland | | 49 |
Pars Distalis, Adenoma | | 11 |
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Carcinoma, Metastatic, Kidney | | 2 |
C-Cell, Adenoma | | 5 |
C-Cell, Carcinoma | | 1 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 50 |
Carcinoma, Metastatic, Kidney | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | | 48 |
Adenoma | | 3 |
__________________________________________________________________________|____________|
Prostate | | 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | | 1 |
__________________________________________________________________________|____________|
Testes | | 50 |
Bilateral, Interstitial Cell, Adenoma| | 27 |
Interstitial Cell, Adenoma | | 13 |
Tunic, Carcinoma, Metastatic, Kidney | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 9 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 105
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| | A |
210 UG/ | 4| 4| 4| 4| 4| | L |
KG | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Femoral, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Inguinal, Leukemia Mononuclear | | 1 |
Lumbar, Leukemia Mononuclear | | 1 |
Mediastinal, Carcinoma, Metastatic, | | |
Kidney | | 7 |
Mediastinal, Leukemia Mononuclear | | 5 |
Pancreatic, Adenocarcinoma, | | |
Metastatic, Stomach | | 1 |
Renal, Leukemia Mononuclear | | 1 |
Renal, Mediastinal, Pancreatic, | | |
Carcinoma, Metastatic, Kidney | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
Carcinoma, Metastatic, Kidney | | 1 |
Carcinoma, Metastatic, Zymbal's Gland| | 1 |
Leukemia Mononuclear | | 7 |
__________________________________________________________________________|____________|
Spleen | | 50 |
Carcinoma, Metastatic, Kidney | | 2 |
Leukemia Mononuclear | | 7 |
__________________________________________________________________________|____________|
Thymus | | 38 |
Carcinoma, Metastatic, Kidney | | 1 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 40 |
Fibroadenoma | | 3 |
__________________________________________________________________________|____________|
Skin | | 49 |
Keratoacanthoma | | 2 |
Squamous Cell Papilloma | | 1 |
Sebaceous Gland, Adenoma | | 1 |
Subcutaneous Tissue, Fibroma | | 2 |
Subcutaneous Tissue, Lipoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Cranium, Osteosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 106
NTP Experiment-Test: 05036-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 11:58:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| | A |
210 UG/ | 4| 4| 4| 4| 4| | L |
KG | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Carcinoma, Metastatic, Kidney | | 13 |
Carcinoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
Leukemia Mononuclear | | 6 |
__________________________________________________________________________|____________|
Nose | | 50 |
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | | 43 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 3 |
Carcinoma | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Leukemia Mononuclear | | 2 |
Bilateral, Renal Tubule, Carcinoma | | 3 |
Bilateral, Renal Tubule, Carcinoma, | | |
Multiple | | 1 |
Capsule, Carcinoma, Metastatic, | | |
Kidney | | 1 |
Lymphatic, Carcinoma, Metastatic, | | |
Kidney | | 1 |
Renal Tubule, Adenoma | | 10 |
Renal Tubule, Carcinoma | | 20 |
Renal Tubule, Carcinoma, Multiple | | 6 |
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 50 |
Leukemia Mononuclear | | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 107
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