TR 358 Rat Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
OCHRATOXIN A
NTP Experiment-Test: 05036-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/05/94
Route: GAVAGE Time: 02:27:31
Facility: Battelle Columbus Laboratory
Chemical CAS #: 303-47-9
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05036-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OCHRATOXIN A Date: 09/05/94
Route: GAVAGE Time: 02:27:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 UG/KG 21 UG/KG 70 UG/KG 210 UG/
KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 80 80 80 80
Scheduled Sacrifice 30 29 30 30
Early Deaths
Moribund 10 22 11 11
Dead 7 3 4 4
Gavage Death 1 3
Survivors
Terminal Sacrifice 32 23 35 34
Dead 1
Animals Examined Microscopically 50 51 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (50) (29) (19) (50)
Carcinoma, Metastatic, Kidney 1 (5%)
Mesentery (1) (1) (1) (1)
Carcinoma, Metastatic, Kidney 1 (100%)
Pancreas (50) (29) (14) (50)
Carcinoma, Metastatic, Kidney 1 (7%)
Acinus, Adenoma 1 (2%)
Pharynx (1)
Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (28) (15) (50)
Sarcoma 1 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (29) (15) (50)
Adenoma 2 (4%)
Carcinoma 1 (2%)
Medulla, Carcinoma, Metastatic, Kidney 1 (7%)
Adrenal Gland, Medulla (50) (27) (15) (50)
Pheochromocytoma Complex 1 (4%)
Pheochromocytoma Benign 3 (6%) 1 (4%) 2 (13%) 4 (8%)
Islets, Pancreatic (50) (28) (14) (50)
Adenoma 1 (7%)
Carcinoma, Multiple 1 (2%)
Page 2
NTP Experiment-Test: 05036-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OCHRATOXIN A Date: 09/05/94
Route: GAVAGE Time: 02:27:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 UG/KG 21 UG/KG 70 UG/KG 210 UG/
KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Parathyroid Gland (39) (17) (13) (42)
Adenoma 1 (2%)
Pituitary Gland (49) (41) (35) (49)
Pars Distalis, Adenoma 16 (33%) 19 (46%) 15 (43%) 22 (45%)
Pars Distalis, Carcinoma 1 (2%) 2 (5%) 1 (3%)
Pars Intermedia, Adenoma 1 (3%)
Pars Intermedia, Carcinoma 1 (3%)
Thyroid Gland (50) (32) (18) (50)
Bilateral, C-Cell, Adenoma 1 (6%) 1 (2%)
C-Cell, Adenoma 7 (14%) 7 (22%) 4 (22%) 2 (4%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 1 (3%)
Follicular Cell, Carcinoma 1 (3%) 1 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (29) (17) (47)
Adenoma 7 (14%) 4 (14%) 2 (12%) 3 (6%)
Carcinoma 1 (6%) 1 (2%)
Bilateral, Adenoma 1 (6%)
Ovary (49) (29) (19) (50)
Carcinoma, Metastatic, Kidney 1 (5%)
Uterus (49) (32) (19) (50)
Leiomyosarcoma 1 (5%)
Polyp Stromal 2 (4%) 7 (22%) 2 (11%) 6 (12%)
Polyp Stromal, Multiple 1 (2%)
Sarcoma Stromal 1 (5%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (2) (2)
Bone Marrow (49) (28) (15) (50)
Lymph Node (50) (27) (16) (50)
Mediastinal, Basosquamous Tumor Malignant,
Metastatic, Thymus 1 (2%)
Lymph Node, Mandibular (50) (26) (15) (50)
Spleen (50) (29) (16) (50)
Thymus (43) (27) (11) (44)
Basosquamous Tumor Malignant 1 (2%)
Thymoma Benign 1 (2%)
Page 3
NTP Experiment-Test: 05036-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OCHRATOXIN A Date: 09/05/94
Route: GAVAGE Time: 02:27:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 UG/KG 21 UG/KG 70 UG/KG 210 UG/
KG
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (47) (40) (34) (49)
Adenocarcinoma 1 (2%) 2 (5%) 2 (6%) 2 (4%)
Adenoma 1 (3%)
Fibroadenoma 13 (28%) 19 (48%) 17 (50%) 14 (29%)
Fibroadenoma, Multiple 4 (9%) 4 (10%) 5 (15%) 14 (29%)
Skin (49) (31) (16) (50)
Basosquamous Tumor Benign 1 (3%)
Squamous Cell Papilloma 2 (6%) 1 (2%)
Subcutaneous Tissue, Fibroma 1 (3%) 1 (6%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 2 (6%) 2 (4%)
Subcutaneous Tissue, Lipoma 1 (3%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (28) (15) (50)
Astrocytoma Malignant 2 (7%)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
Oligodendroglioma Malignant 1 (7%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (32) (18) (50)
Alveolar/Bronchiolar Adenoma 1 (3%) 1 (2%)
Basosquamous Tumor Malignant, Metastatic,
Thymus 1 (2%)
Carcinoma, Metastatic, Kidney 1 (6%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (2)
Carcinoma 1 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05036-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OCHRATOXIN A Date: 09/05/94
Route: GAVAGE Time: 02:27:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 UG/KG 21 UG/KG 70 UG/KG 210 UG/
KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (51) (50) (50)
Renal Tubule, Adenoma 1 (2%) 3 (6%)
Renal Tubule, Adenoma, Multiple 2 (4%)
Renal Tubule, Carcinoma 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(51) *(50) *(50)
Leukemia Mononuclear 10 (20%) 8 (16%) 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05036-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OCHRATOXIN A Date: 09/05/94
Route: GAVAGE Time: 02:27:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 UG/KG 21 UG/KG 70 UG/KG 210 UG/
KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 39 44 40 45
Total Primary Neoplasms 70 88 68 90
Total Animals with Benign Neoplasms 34 38 34 42
Total Benign Neoplasms 54 68 54 77
Total Animals with Malignant Neoplasms 14 19 13 10
Total Malignant Neoplasms 16 20 14 13
Total Animals with Metastatic Neoplasms 1 1 1
Total Metastatic Neoplasm 1 6 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05036-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OCHRATOXIN A Date: 09/05/94
Route: GAVAGE Time: 02:27:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 UG/KG 21 UG/KG 70 UG/KG 210 UG/
KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 80 80 80 80
Scheduled Sacrifice 30 29 29 30
Early Deaths
Gavage Death 4 6 2 1
Moribund 7 13 14 23
Dead 6 9 3
Survivors
Terminal Sacrifice 39 26 26 23
Animals Examined Microscopically 50 51 51 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Ileum (50) (24) (21) (50)
Adenocarcinoma 1 (2%)
Liver (50) (26) (26) (50)
Carcinoma, Metastatic, Kidney 2 (4%)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Carcinoma, Multiple 1 (2%)
Neoplastic Nodule 1 (2%)
Mesentery (1) (7) (5) (11)
Carcinoma, Metastatic, Kidney 1 (20%) 8 (73%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (14%)
Pancreas (50) (26) (24) (50)
Carcinoma, Metastatic, Kidney 4 (17%) 3 (6%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (4%)
Acinus, Adenoma 3 (6%) 3 (12%) 3 (6%)
Acinus, Adenoma, Multiple 1 (2%)
Pharynx (1)
Palate, Squamous Cell Papilloma 1 (100%)
Salivary Glands (50) (26) (25) (49)
Acinus, Adenoma 1 (2%)
Stomach, Forestomach (50) (25) (25) (50)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (50) (25) (25) (49)
Adenocarcinoma 1 (2%)
Tongue (3) (2) (2)
Squamous Cell Papilloma 2 (67%) 2 (100%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05036-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OCHRATOXIN A Date: 09/05/94
Route: GAVAGE Time: 02:27:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 UG/KG 21 UG/KG 70 UG/KG 210 UG/
KG
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (26) (25) (50)
Carcinoma, Metastatic, Kidney 2 (4%)
Atrium, Sarcoma, Metastatic, Uncertain
Primary Site 1 (4%)
Epicardium, Carcinoma, Metastatic, Kidney 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (25) (25) (50)
Adenoma 2 (4%)
Medulla, Carcinoma, Metastatic, Kidney 1 (2%)
Adrenal Gland, Medulla (50) (25) (26) (49)
Pheochromocytoma Malignant 2 (8%) 1 (2%)
Pheochromocytoma Complex 1 (2%) 1 (4%) 1 (2%)
Pheochromocytoma Benign 13 (26%) 4 (16%) 3 (12%) 9 (18%)
Bilateral, Pheochromocytoma Benign 4 (8%) 2 (8%) 2 (4%)
Islets, Pancreatic (50) (26) (26) (50)
Adenoma 4 (8%) 2 (8%) 3 (12%) 1 (2%)
Adenoma, Multiple 1 (2%)
Carcinoma 1 (2%) 1 (4%) 1 (2%)
Parathyroid Gland (41) (21) (21) (47)
Adenoma 2 (5%)
Pituitary Gland (50) (33) (27) (49)
Pars Distalis, Adenoma 14 (28%) 16 (48%) 7 (26%) 11 (22%)
Pars Distalis, Carcinoma 2 (6%) 2 (7%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (50) (29) (26) (50)
Carcinoma, Metastatic, Kidney 2 (4%)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 8 (16%) 5 (17%) 6 (23%) 5 (10%)
C-Cell, Carcinoma 1 (3%) 1 (4%) 1 (2%)
Follicular Cell, Adenoma 1 (2%) 1 (4%) 1 (2%)
Follicular Cell, Carcinoma 2 (4%) 1 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1) (2)
Sarcoma 1 (100%) 1 (50%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (100%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05036-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OCHRATOXIN A Date: 09/05/94
Route: GAVAGE Time: 02:27:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 UG/KG 21 UG/KG 70 UG/KG 210 UG/
KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (26) (25) (50)
Carcinoma, Metastatic, Kidney 1 (2%)
Preputial Gland (50) (28) (25) (48)
Adenoma 6 (12%) 3 (11%) 1 (4%) 3 (6%)
Testes (50) (50) (48) (50)
Bilateral, Interstitial Cell, Adenoma 39 (78%) 34 (68%) 32 (67%) 27 (54%)
Interstitial Cell, Adenoma 5 (10%) 5 (10%) 10 (21%) 13 (26%)
Tunic, Carcinoma, Metastatic, Kidney 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (1) (9)
Bone Marrow (50) (25) (25) (50)
Lymph Node (50) (28) (25) (50)
Mediastinal, Carcinoma, Metastatic, Kidney 2 (8%) 7 (14%)
Mediastinal, Sarcoma, Metastatic, Uncertain
Primary Site 1 (4%)
Mediastinal, Squamous Cell Carcinoma,
Metastatic, Lung 1 (4%)
Pancreatic, Adenocarcinoma, Metastatic,
Stomach 1 (2%)
Renal, Mediastinal, Pancreatic, Carcinoma,
Metastatic, Kidney 1 (4%) 1 (2%)
Lymph Node, Mandibular (49) (28) (23) (50)
Carcinoma, Metastatic, Kidney 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Spleen (50) (29) (27) (50)
Carcinoma, Metastatic, Kidney 1 (4%) 2 (4%)
Fibrosarcoma 1 (2%) 1 (4%)
Thymus (41) (22) (20) (38)
Carcinoma, Metastatic, Kidney 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (39) (22) (23) (40)
Adenoma 1 (4%)
Fibroadenoma 3 (8%) 2 (9%) 1 (4%) 3 (8%)
Skin (49) (32) (30) (49)
Basosquamous Tumor Benign 1 (3%) 1 (3%)
Keratoacanthoma 1 (2%) 1 (3%) 4 (13%) 2 (4%)
Squamous Cell Papilloma 2 (4%) 1 (3%) 4 (13%) 1 (2%)
Trichoepithelioma 1 (2%)
Sebaceous Gland, Adenoma 1 (2%) 1 (3%) 1 (3%) 1 (2%)
Subcutaneous Tissue, Fibroma 4 (8%) 4 (13%) 1 (3%) 2 (4%)
Page 9
NTP Experiment-Test: 05036-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OCHRATOXIN A Date: 09/05/94
Route: GAVAGE Time: 02:27:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 UG/KG 21 UG/KG 70 UG/KG 210 UG/
KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 2 (7%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%) 1 (3%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (26) (25) (50)
Cranium, Osteosarcoma 1 (2%)
Skeletal Muscle (1)
Diaphragm, Sarcoma, Metastatic, Uncertain
Primary Site 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (25) (25) (50)
Astrocytoma Malignant 1 (2%) 1 (4%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (4%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (30) (27) (50)
Alveolar/Bronchiolar Adenoma 3 (10%)
Alveolar/Bronchiolar Carcinoma 1 (3%)
Carcinoma, Metastatic, Kidney 3 (11%) 13 (26%)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Gland 2 (7%)
Squamous Cell Carcinoma 1 (4%)
Mediastinum, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (3%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (2) (3)
Carcinoma 2 (100%) 3 (100%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 05036-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OCHRATOXIN A Date: 09/05/94
Route: GAVAGE Time: 02:27:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 UG/KG 21 UG/KG 70 UG/KG 210 UG/
KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (51) (51) (50)
Mixed Tumor Malignant 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Bilateral, Renal Tubule, Carcinoma 1 (2%) 3 (6%)
Bilateral, Renal Tubule, Carcinoma, Multiple 1 (2%)
Capsule, Carcinoma, Metastatic, Kidney 1 (2%)
Lymphatic, Carcinoma, Metastatic, Kidney 1 (2%)
Renal Tubule, Adenoma 1 (2%) 1 (2%) 3 (6%) 10 (20%)
Renal Tubule, Carcinoma 12 (24%) 20 (40%)
Renal Tubule, Carcinoma, Multiple 3 (6%) 6 (12%)
Renal Tubule, Epithelium, Adenoma 2 (4%)
Renal Tubule, Epithelium, Adenoma, Multiple 1 (2%)
Urinary Bladder (50) (23) (24) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(51) *(51) *(50)
Leukemia Mononuclear 12 (24%) 7 (14%) 7 (14%) 7 (14%)
Mesothelioma Benign 1 (2%)
Mesothelioma Malignant 1 (2%) 4 (8%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 05036-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OCHRATOXIN A Date: 09/05/94
Route: GAVAGE Time: 02:27:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 UG/KG 21 UG/KG 70 UG/KG 210 UG/
KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 47 47 50 50
Total Primary Neoplasms 143 107 123 146
Total Animals with Benign Neoplasms 47 46 48 44
Total Benign Neoplasms 120 89 86 97
Total Animals with Malignant Neoplasms 22 17 28 39
Total Malignant Neoplasms 23 18 37 49
Total Animals with Metastatic Neoplasms 2 9 16
Total Metastatic Neoplasm 7 17 51
Total Animals with Malignant Neoplasms 1 2 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 12
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