TR 358 Rat Pathology Tables
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
Facility: Battelle Columbus Laboratory
Chemical CAS #: 303-47-9
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 2| 4| 5| 7| 7| 5| 7| 7| 6| 7| 6|
DAY ON TEST | 2| 9| 2| 2| 4| 2| 8| 2| 2| 2| 5| 6| 2| 2| 1| 6| 8| 2| 2| 2| 2| 2| 7| 2| 5|
| 8| 5| 8| 8| 8| 8| 9| 8| 8| 8| 4| 0| 8| 9| 6| 6| 3| 9| 9| 5| 9| 9| 3| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0 UG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + + M + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Eosinophilic Focus | X |
Inflammation, Chronic Active, | |
Multifocal | 2 2 2 2 2 2 3|
Bile Duct, Hyperplasia, Multifocal | 2 2 |
Centrilobular, Degeneration | 2 2 |
Centrilobular, Vacuolization | |
Cytoplasmic, Diffuse | 2 |
Periportal, Vacuolization | |
Cytoplasmic, Diffuse | 3 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 3 2 2 2 2 2|
Acinus, Degeneration, Multifocal | 2 |
__________________________________________________________________________|
Pharynx | +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, | |
Multifocal | 3|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Tongue | +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 2| 4| 5| 7| 7| 5| 7| 7| 6| 7| 6|
DAY ON TEST | 2| 9| 2| 2| 4| 2| 8| 2| 2| 2| 5| 6| 2| 2| 1| 6| 8| 2| 2| 2| 2| 2| 7| 2| 5|
| 8| 5| 8| 8| 8| 8| 9| 8| 8| 8| 4| 0| 8| 9| 6| 6| 3| 9| 9| 5| 9| 9| 3| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0 UG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 3 2 2 2 |
Degeneration | 3 |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 |
Hyperplasia | 3 2 2 2 2 2 2|
Hypertrophy | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + M M + + + M M + + + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X X X X X X X X X X X |
Pars Distalis, Hyperplasia | 3 2 2 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Infiltration Cellular, Focal, | |
Lipocyte | |
Duct, Cyst | |
__________________________________________________________________________|
Ovary | + M + + + + + + + + + + + + + + + + + + + + + + +|
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + M + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Endometrium, Hyperplasia, Cystic, | |
Glandular, Multifocal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + I + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pancreatic, Inflammation, Chronic | |
Active, Multifocal | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 2| 4| 5| 7| 7| 5| 7| 7| 6| 7| 6|
DAY ON TEST | 2| 9| 2| 2| 4| 2| 8| 2| 2| 2| 5| 6| 2| 2| 1| 6| 8| 2| 2| 2| 2| 2| 7| 2| 5|
| 8| 5| 8| 8| 8| 8| 9| 8| 8| 8| 4| 0| 8| 9| 6| 6| 3| 9| 9| 5| 9| 9| 3| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0 UG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Multifocal, Reticulum | |
Cell | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + + + M M M M +|
Depletion Lymphoid, Multifocal | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia, Cystic, Multifocal | 3 3 2 3 3 2 3 3 3 3 4 3 3 3 2 4 3 3 3 3 3 3 3 3|
__________________________________________________________________________|
Skin | + + + + M + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
Cyst | X |
Hemorrhage, Multifocal | 3 |
Inflammation, Chronic, Multifocal | 3 |
Ventricle, Hydrocephalus | 3 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body, Multifocal | |
Interstitium, Inflammation, Chronic | |
Active, Multifocal | 2 2 2 3 1 2 1 2 3 3 2 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Foreign Body | 2 2 2 2 2|
Mucosa, Inflammation, Acute, | |
Multifocal | 2 2 2 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + + |
Lens, Cataract | 3 3 |
Retina, Atrophy, Diffuse | 4 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 2| 4| 5| 7| 7| 5| 7| 7| 6| 7| 6|
DAY ON TEST | 2| 9| 2| 2| 4| 2| 8| 2| 2| 2| 5| 6| 2| 2| 1| 6| 8| 2| 2| 2| 2| 2| 7| 2| 5|
| 8| 5| 8| 8| 8| 8| 9| 8| 8| 8| 4| 0| 8| 9| 6| 6| 3| 9| 9| 5| 9| 9| 3| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0 UG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic, Diffuse | 1 1 1 2 2 1 1 2 2 1 1 2 2 2 2 1 1 2|
Renal Tubule, Epithelium, | |
Pigmentation, Diffuse | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 9| 2| 2| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 3| 7| 9| 3| 3| 3| 3| 3|
| 9| 7| 5| 9| 8| 0| 0| 0| 0| 0| 0| 0| 1| 0| 8| 1| 1| 1| 5| 5| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0 UG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | X X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Eosinophilic Focus | |
Inflammation, Chronic Active, | |
Multifocal | 2 2 2 2 2 2 2 2 |
Bile Duct, Hyperplasia, Multifocal | 3 2 2 2 3 2 2 2 2 2 2|
Centrilobular, Degeneration | |
Centrilobular, Vacuolization | |
Cytoplasmic, Diffuse | |
Periportal, Vacuolization | |
Cytoplasmic, Diffuse | 2 3 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 2 2 2 2 |
Acinus, Degeneration, Multifocal | |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, | |
Multifocal | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 9| 2| 2| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 3| 7| 9| 3| 3| 3| 3| 3|
| 9| 7| 5| 9| 8| 0| 0| 0| 0| 0| 0| 0| 1| 0| 8| 1| 1| 1| 5| 5| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0 UG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 2 3 2 2 2 2 2 3|
Degeneration | 2 |
Hematopoietic Cell Proliferation, | |
Multifocal | |
Hyperplasia | 2 2 2 2 2 2 2 |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + M + + + + M + M + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + I + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X X X X X X |
Pars Distalis, Hyperplasia | 2 2 3 3 2 3 2 2 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2|
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
Infiltration Cellular, Focal, | |
Lipocyte | 3 |
Duct, Cyst | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periovarian Tissue, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Endometrium, Hyperplasia, Cystic, | |
Glandular, Multifocal | 3 3 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pancreatic, Inflammation, Chronic | |
Active, Multifocal | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Multifocal | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 9| 2| 2| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 3| 7| 9| 3| 3| 3| 3| 3|
| 9| 7| 5| 9| 8| 0| 0| 0| 0| 0| 0| 0| 1| 0| 8| 1| 1| 1| 5| 5| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0 UG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Multifocal, Reticulum | |
Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | |
__________________________________________________________________________|
Thymus | M + + + + + + + M + + + + + + + + + + + + + + + +|
Depletion Lymphoid, Multifocal | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia, Cystic, Multifocal | 3 3 3 3 3 2 3 4 3 2 3 3 3 3 3 2 3 3 3 2 4 4|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 3 |
Cyst | |
Hemorrhage, Multifocal | |
Inflammation, Chronic, Multifocal | |
Ventricle, Hydrocephalus | 3 3 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body, Multifocal | 2 1 3 2 |
Interstitium, Inflammation, Chronic | |
Active, Multifocal | 3 2 1 2 2 3 1 3 1 2 2 1 4 1 1 2 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Foreign Body | 2 2 |
Mucosa, Inflammation, Acute, | |
Multifocal | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Atrophy, Diffuse | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 9| 2| 2| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 3| 7| 9| 3| 3| 3| 3| 3|
| 9| 7| 5| 9| 8| 0| 0| 0| 0| 0| 0| 0| 1| 0| 8| 1| 1| 1| 5| 5| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0 UG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic, Diffuse | 2 2 3 1 1 1 2 1 2 2 1 1 1 1 2 1 1 |
Renal Tubule, Epithelium, | |
Pigmentation, Diffuse | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 UG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | |
__________________________________________________________________________|
Intestine Large | |
__________________________________________________________________________|
Intestine Large, Cecum | |
__________________________________________________________________________|
Intestine Large, Colon | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | |
__________________________________________________________________________|
Intestine Small, Duodenum | |
__________________________________________________________________________|
Intestine Small, Ileum | |
__________________________________________________________________________|
Intestine Small, Jejunum | |
__________________________________________________________________________|
Liver | |
Basophilic Focus, Multiple | |
Clear Cell Focus | |
Eosinophilic Focus | |
Inflammation, Chronic Active, | |
Multifocal | |
Bile Duct, Hyperplasia, Multifocal | |
Centrilobular, Degeneration | |
Centrilobular, Vacuolization | |
Cytoplasmic, Diffuse | |
Periportal, Vacuolization | |
Cytoplasmic, Diffuse | |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | |
Acinus, Atrophy | |
Acinus, Degeneration, Multifocal | |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | |
Inflammation, Chronic Active, | |
Multifocal | |
__________________________________________________________________________|
Stomach | |
__________________________________________________________________________|
Stomach, Forestomach | |
Cyst Epithelial Inclusion | |
__________________________________________________________________________|
Stomach, Glandular | |
Ulcer | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | |
Degeneration, Chronic, Multifocal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 UG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | |
__________________________________________________________________________|
Adrenal Gland, Cortex | |
Degeneration, Fatty | |
Degeneration | |
Hematopoietic Cell Proliferation, | |
Multifocal | |
Hyperplasia | |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | |
__________________________________________________________________________|
Parathyroid Gland | |
__________________________________________________________________________|
Pituitary Gland | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | |
C-Cell, Hyperplasia | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Hyperplasia | |
Infiltration Cellular, Focal, | |
Lipocyte | |
Duct, Cyst | |
__________________________________________________________________________|
Ovary | |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | |
Dilatation | |
Endometrium, Hyperplasia, Cystic, | |
Glandular, Multifocal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | |
__________________________________________________________________________|
Lymph Node | |
Pancreatic, Inflammation, Chronic | |
Active, Multifocal | |
__________________________________________________________________________|
Lymph Node, Mandibular | |
Hemorrhage, Multifocal | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 UG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Multifocal, Reticulum | |
Cell | |
__________________________________________________________________________|
Spleen | |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | |
__________________________________________________________________________|
Thymus | |
Depletion Lymphoid, Multifocal | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | |
Hyperplasia, Cystic, Multifocal | |
__________________________________________________________________________|
Skin | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
Femur, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | |
Compression | |
Cyst | |
Hemorrhage, Multifocal | |
Inflammation, Chronic, Multifocal | |
Ventricle, Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | |
Foreign Body, Multifocal | |
Interstitium, Inflammation, Chronic | |
Active, Multifocal | |
__________________________________________________________________________|
Nose | |
Lumen, Foreign Body | |
Mucosa, Inflammation, Acute, | |
Multifocal | |
__________________________________________________________________________|
Trachea | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Atrophy, Diffuse | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 UG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | |
Nephropathy, Chronic, Diffuse | |
Renal Tubule, Epithelium, | |
Pigmentation, Diffuse | |
__________________________________________________________________________|
Urinary Bladder | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| | A |
0 UG/KG | 3| 3| 3| 3| 3| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 49 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 48 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 49 |
__________________________________________________________________________|____________|
Liver | | 50 |
Basophilic Focus, Multiple | | 41 |
Clear Cell Focus | | 4 |
Eosinophilic Focus | | 1 |
Inflammation, Chronic Active, | | |
Multifocal | | 15 2.1|
Bile Duct, Hyperplasia, Multifocal | | 13 2.2|
Centrilobular, Degeneration | | 2 2.0|
Centrilobular, Vacuolization | | |
Cytoplasmic, Diffuse | | 1 2.0|
Periportal, Vacuolization | | |
Cytoplasmic, Diffuse | | 3 2.7|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Acinus, Atrophy | | 12 2.2|
Acinus, Degeneration, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
Inflammation, Chronic Active, | | |
Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Cyst Epithelial Inclusion | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| | A |
0 UG/KG | 3| 3| 3| 3| 3| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Degeneration, Chronic, Multifocal | | 34 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Degeneration, Fatty | | 13 2.2|
Degeneration | | 2 2.5|
Hematopoietic Cell Proliferation, | | |
Multifocal | | 1 2.0|
Hyperplasia | | 14 2.1|
Hypertrophy | | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 39 |
__________________________________________________________________________|____________|
Pituitary Gland | | 49 |
Pars Distalis, Cyst | | 21 |
Pars Distalis, Hyperplasia | | 15 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
C-Cell, Hyperplasia | | 24 2.0|
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 49 |
Hyperplasia | | 3 2.0|
Infiltration Cellular, Focal, | | |
Lipocyte | | 1 3.0|
Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Ovary | | 49 |
Periovarian Tissue, Cyst | | 1 |
__________________________________________________________________________|____________|
Uterus | | 49 |
Dilatation | | 1 3.0|
Endometrium, Hyperplasia, Cystic, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| | A |
0 UG/KG | 3| 3| 3| 3| 3| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Glandular, Multifocal | | 3 3.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | | 49 |
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Pancreatic, Inflammation, Chronic | | |
Active, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
Hemorrhage, Multifocal | | 1 2.0|
Hyperplasia, Multifocal, Reticulum | | |
Cell | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | | 50 |
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | | 2 3.0|
__________________________________________________________________________|____________|
Thymus | | 43 |
Depletion Lymphoid, Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 47 |
Hyperplasia, Cystic, Multifocal | | 46 3.0|
__________________________________________________________________________|____________|
Skin | | 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Femur, Hyperostosis | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Compression | | 5 3.0|
Cyst | | 1 |
Hemorrhage, Multifocal | | 1 3.0|
Inflammation, Chronic, Multifocal | | 1 3.0|
Ventricle, Hydrocephalus | | 5 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Foreign Body, Multifocal | | 4 2.0|
Interstitium, Inflammation, Chronic | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| | A |
0 UG/KG | 3| 3| 3| 3| 3| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Active, Multifocal | | 30 2.1|
__________________________________________________________________________|____________|
Nose | | 50 |
Lumen, Foreign Body | | 7 2.0|
Mucosa, Inflammation, Acute, | | |
Multifocal | | 5 2.2|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 4 |
Lens, Cataract | | 2 3.0|
Retina, Atrophy, Diffuse | | 2 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 49 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Nephropathy, Chronic, Diffuse | | 35 1.5|
Renal Tubule, Epithelium, | | |
Pigmentation, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 4| 4| 6| 7| 7| 7| 0| 7| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7|
DAY ON TEST | 8| 1| 2| 3| 2| 2| 2| 1| 5| 7| 2| 2| 2| 0| 2| 3| 5| 1| 2| 2| 2| 2| 6| 5| 2|
| 5| 8| 8| 8| 8| 8| 8| 5| 2| 4| 8| 8| 9| 5| 9| 2| 8| 6| 6| 9| 9| 9| 5| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
21 UG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + |
Basophilic Focus, Multiple | X X X X X X X |
Cytoplasmic Alteration, Focal | |
Inflammation, Chronic Active, | |
Multifocal | 2 2 |
Bile Duct, Hyperplasia, Multifocal | 2 3 |
Centrilobular, Vacuolization | |
Cytoplasmic, Diffuse | |
Periportal, Vacuolization | |
Cytoplasmic, Diffuse | 2 3 |
__________________________________________________________________________|
Mesentery | |
Perivascular, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + |
Acinus, Atrophy | 2 4 |
Perivascular, Inflammation, Chronic | |
Active, Multifocal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + |
Degeneration, Chronic, Multifocal | 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + |
Degeneration, Fatty | 2 2 2 |
Hyperplasia | 2 2 2 |
Hypertrophy | |
Necrosis, Acute | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 4| 4| 6| 7| 7| 7| 0| 7| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7|
DAY ON TEST | 8| 1| 2| 3| 2| 2| 2| 1| 5| 7| 2| 2| 2| 0| 2| 3| 5| 1| 2| 2| 2| 2| 6| 5| 2|
| 5| 8| 8| 8| 8| 8| 8| 5| 2| 4| 8| 8| 9| 5| 9| 2| 8| 6| 6| 9| 9| 9| 5| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
21 UG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + M M + + M M M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Cyst | X X X X X |
Pars Distalis, Hyperplasia | 3 2 2 2 3 3 2 |
Pars Nervosa, Hyperplasia, Glandular | |
Rathke's Cleft, Cyst | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 2 2 2 2 2 2 2 |
Follicular Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 2 |
Duct, Cyst | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + |
Follicle, Cyst | X |
Periovarian Tissue, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + |
Dilatation | 3 |
Inflammation, Chronic Active | 4 |
Endometrium, Hyperplasia, Cystic, | |
Glandular, Multifocal | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + |
Mesenteric, Sinus, Ectasia | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + |
Depletion Lymphoid | 2 |
Red Pulp, Fibrosis | 1 |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic, Multifocal | 3 3 2 2 3 2 3 3 3 3 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 4| 4| 6| 7| 7| 7| 0| 7| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7|
DAY ON TEST | 8| 1| 2| 3| 2| 2| 2| 1| 5| 7| 2| 2| 2| 0| 2| 3| 5| 1| 2| 2| 2| 2| 6| 5| 2|
| 5| 8| 8| 8| 8| 8| 8| 5| 2| 4| 8| 8| 9| 5| 9| 2| 8| 6| 6| 9| 9| 9| 5| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
21 UG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + |
Compression | 3 3 |
Ventricle, Hydrocephalus | 2 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + |
Foreign Body, Multifocal | 2 3 |
Alveolar Epithelium, Hyperplasia | 3 |
Interstitium, Inflammation, Chronic | |
Active, Multifocal | 2 1 2 3 3 |
Perivascular, Edema, Acute | 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Hyperplasia | 2 |
Lens, Cataract | |
Retina, Atrophy, Diffuse | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic, Diffuse | 1 4 1 2 1 1 1 1 2 1 2 1 2 2 1 2 2 1 3 |
Renal Tubule, Epithelium, | |
Karyomegaly, Multifocal | 1 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + |
Hemorrhage | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 5| 7| 4| 5| 6| 7| 6| 6|
DAY ON TEST | 3| 1| 5| 4| 3| 0| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 7| 2| 3| 4| 6|
| 0| 6| 8| 6| 0| 4| 0| 0| 0| 5| 0| 1| 1| 7| 1| 2| 6| 8| 1| 6| 7| 4| 1| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
21 UG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | X X X X X X X X |
Cytoplasmic Alteration, Focal | 3 2 |
Inflammation, Chronic Active, | |
Multifocal | 2 |
Bile Duct, Hyperplasia, Multifocal | 2 |
Centrilobular, Vacuolization | |
Cytoplasmic, Diffuse | 2 3 2 |
Periportal, Vacuolization | |
Cytoplasmic, Diffuse | |
__________________________________________________________________________|
Mesentery | + |
Perivascular, Inflammation, Chronic | |
Active | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Perivascular, Inflammation, Chronic | |
Active, Multifocal | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + +|
Degeneration, Chronic, Multifocal | 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + +|
Degeneration, Fatty | |
Hyperplasia | 2 3 2 |
Hypertrophy | 2 2 |
Necrosis, Acute | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 5| 7| 4| 5| 6| 7| 6| 6|
DAY ON TEST | 3| 1| 5| 4| 3| 0| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 7| 2| 3| 4| 6|
| 0| 6| 8| 6| 0| 4| 0| 0| 0| 5| 0| 1| 1| 7| 1| 2| 6| 8| 1| 6| 7| 4| 1| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
21 UG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + M + M + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hyperplasia | 3 2 |
Pars Nervosa, Hyperplasia, Glandular | 2 |
Rathke's Cleft, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 2 2 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + M|
Inflammation, Chronic Active | |
Duct, Cyst | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + +|
Follicle, Cyst | X |
Periovarian Tissue, Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + +|
Dilatation | |
Inflammation, Chronic Active | |
Endometrium, Hyperplasia, Cystic, | |
Glandular, Multifocal | 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + M + + + + +|
Mesenteric, Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Red Pulp, Fibrosis | |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + I|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + M M + + + + + + + +|
Hyperplasia, Cystic, Multifocal | 3 4 3 3 3 3 3 2 2 3 3 3|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 5| 7| 4| 5| 6| 7| 6| 6|
DAY ON TEST | 3| 1| 5| 4| 3| 0| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 7| 2| 3| 4| 6|
| 0| 6| 8| 6| 0| 4| 0| 0| 0| 5| 0| 1| 1| 7| 1| 2| 6| 8| 1| 6| 7| 4| 1| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
21 UG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + +|
Compression | 3 2 3 2 3|
Ventricle, Hydrocephalus | 3 3 2 3 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + +|
Foreign Body, Multifocal | 2 1 2 |
Alveolar Epithelium, Hyperplasia | 2 2 |
Interstitium, Inflammation, Chronic | |
Active, Multifocal | 2 3 2 3 2 2 2|
Perivascular, Edema, Acute | 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
Cornea, Hyperplasia | |
Lens, Cataract | 2|
Retina, Atrophy, Diffuse | 2|
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + M + + +|
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic, Diffuse | 2 2 2 3 2 4 2 1 1 2 2 1 3 2 1 3 2 3 3 2|
Renal Tubule, Epithelium, | |
Karyomegaly, Multifocal | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + M + + + +|
Hemorrhage | 3 |
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
21 UG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + |
__________________________________________________________________________|
Intestine Large | + |
__________________________________________________________________________|
Intestine Large, Cecum | + |
__________________________________________________________________________|
Intestine Large, Colon | + |
__________________________________________________________________________|
Intestine Large, Rectum | + |
__________________________________________________________________________|
Intestine Small | + |
__________________________________________________________________________|
Intestine Small, Duodenum | + |
__________________________________________________________________________|
Intestine Small, Ileum | + |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
__________________________________________________________________________|
Liver | + |
Basophilic Focus, Multiple | |
Cytoplasmic Alteration, Focal | |
Inflammation, Chronic Active, | |
Multifocal | |
Bile Duct, Hyperplasia, Multifocal | |
Centrilobular, Vacuolization | |
Cytoplasmic, Diffuse | |
Periportal, Vacuolization | |
Cytoplasmic, Diffuse | |
__________________________________________________________________________|
Mesentery | |
Perivascular, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Pancreas | + |
Acinus, Atrophy | |
Perivascular, Inflammation, Chronic | |
Active, Multifocal | |
__________________________________________________________________________|
Salivary Glands | + |
__________________________________________________________________________|
Stomach | + |
__________________________________________________________________________|
Stomach, Forestomach | + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + |
Degeneration, Chronic, Multifocal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + |
Degeneration, Fatty | |
Hyperplasia | |
Hypertrophy | |
Necrosis, Acute | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
21 UG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + |
__________________________________________________________________________|
Parathyroid Gland | M |
__________________________________________________________________________|
Pituitary Gland | + |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
Pars Nervosa, Hyperplasia, Glandular | |
Rathke's Cleft, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + |
C-Cell, Hyperplasia | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Inflammation, Chronic Active | |
Duct, Cyst | |
__________________________________________________________________________|
Ovary | + |
Follicle, Cyst | |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + |
Dilatation | |
Inflammation, Chronic Active | |
Endometrium, Hyperplasia, Cystic, | |
Glandular, Multifocal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + |
__________________________________________________________________________|
Lymph Node | + |
Mesenteric, Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + |
__________________________________________________________________________|
Spleen | + |
Depletion Lymphoid | |
Red Pulp, Fibrosis | |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 3 |
__________________________________________________________________________|
Thymus | + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + |
Hyperplasia, Cystic, Multifocal | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
21 UG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + |
Compression | |
Ventricle, Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + |
Foreign Body, Multifocal | |
Alveolar Epithelium, Hyperplasia | |
Interstitium, Inflammation, Chronic | |
Active, Multifocal | |
Perivascular, Edema, Acute | |
__________________________________________________________________________|
Nose | + |
__________________________________________________________________________|
Trachea | + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Hyperplasia | |
Lens, Cataract | |
Retina, Atrophy, Diffuse | |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + |
Nephropathy, Chronic, Diffuse | 1 |
Renal Tubule, Epithelium, | |
Karyomegaly, Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + |
Hemorrhage | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| | A |
21 UG/KG | 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 28 |
__________________________________________________________________________|____________|
Intestine Large | | 28 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 28 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 28 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 28 |
__________________________________________________________________________|____________|
Intestine Small | | 28 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 28 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 28 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 28 |
__________________________________________________________________________|____________|
Liver | | 29 |
Basophilic Focus, Multiple | | 15 |
Cytoplasmic Alteration, Focal | | 2 2.5|
Inflammation, Chronic Active, | | |
Multifocal | | 3 2.0|
Bile Duct, Hyperplasia, Multifocal | | 3 2.3|
Centrilobular, Vacuolization | | |
Cytoplasmic, Diffuse | | 3 2.3|
Periportal, Vacuolization | | |
Cytoplasmic, Diffuse | | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Perivascular, Inflammation, Chronic | | |
Active | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | | 29 |
Acinus, Atrophy | | 2 3.0|
Perivascular, Inflammation, Chronic | | |
Active, Multifocal | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | | 28 |
__________________________________________________________________________|____________|
Stomach | | 28 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 28 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 28 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 28 |
Degeneration, Chronic, Multifocal | | 10 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 29 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 29 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| | A |
21 UG/KG | 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Degeneration, Fatty | | 3 2.0|
Hyperplasia | | 6 2.2|
Hypertrophy | | 2 2.0|
Necrosis, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 27 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 28 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 17 |
__________________________________________________________________________|____________|
Pituitary Gland | | 41 |
Pars Distalis, Cyst | | 9 |
Pars Distalis, Hyperplasia | | 9 2.4|
Pars Nervosa, Hyperplasia, Glandular | | 1 2.0|
Rathke's Cleft, Cyst | | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | | 32 |
C-Cell, Hyperplasia | | 14 2.0|
Follicular Cell, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 29 |
Inflammation, Chronic Active | | 1 2.0|
Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Ovary | | 29 |
Follicle, Cyst | | 2 |
Periovarian Tissue, Cyst | | 3 |
__________________________________________________________________________|____________|
Uterus | | 32 |
Dilatation | | 1 3.0|
Inflammation, Chronic Active | | 1 4.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular, Multifocal | | 4 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | | 28 |
__________________________________________________________________________|____________|
Lymph Node | | 27 |
Mesenteric, Sinus, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 26 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| | A |
21 UG/KG | 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | | 29 |
Depletion Lymphoid | | 1 2.0|
Red Pulp, Fibrosis | | 1 1.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | | 3 3.0|
__________________________________________________________________________|____________|
Thymus | | 27 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 40 |
Hyperplasia, Cystic, Multifocal | | 22 2.8|
__________________________________________________________________________|____________|
Skin | | 31 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 28 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 28 |
Compression | | 7 2.7|
Ventricle, Hydrocephalus | | 7 2.6|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 32 |
Foreign Body, Multifocal | | 5 2.0|
Alveolar Epithelium, Hyperplasia | | 3 2.3|
Interstitium, Inflammation, Chronic | | |
Active, Multifocal | | 12 2.3|
Perivascular, Edema, Acute | | 4 2.5|
__________________________________________________________________________|____________|
Nose | | 28 |
__________________________________________________________________________|____________|
Trachea | | 28 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cornea, Hyperplasia | | 1 2.0|
Lens, Cataract | | 1 2.0|
Retina, Atrophy, Diffuse | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 27 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| | A |
21 UG/KG | 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 51 |
Nephropathy, Chronic, Diffuse | | 40 1.9|
Renal Tubule, Epithelium, | | |
Karyomegaly, Multifocal | | 8 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 27 |
Hemorrhage | | 1 3.0|
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 5| 6| 7|
DAY ON TEST | 2| 2| 2| 2| 0| 2| 2| 2| 2| 6| 2| 6| 2| 5| 2| 2| 2| 2| 2| 2| 6| 2| 8| 9| 3|
| 8| 8| 8| 8| 6| 8| 8| 8| 8| 7| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 UG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + |
Basophilic Focus, Multiple | X X X X X X X |
Cytoplasmic Alteration, Focal | 2 |
Inflammation, Chronic Active, | |
Multifocal | 2 |
Bile Duct, Hyperplasia, Multifocal | 2 3 |
Centrilobular, Vacuolization | |
Cytoplasmic, Diffuse | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + |
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + |
__________________________________________________________________________|
Tongue | +|
Epithelium, Hyperkeratosis, Focal | 2|
Epithelium, Hyperplasia | 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + |
Degeneration, Chronic, Multifocal | 2 2 2 2 2 2 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + |
Accessory Adrenal Cortical Nodule | X |
Degeneration, Fatty, Focal | |
Degeneration, Fatty | 2 2 |
Necrosis, Acute | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 5| 6| 7|
DAY ON TEST | 2| 2| 2| 2| 0| 2| 2| 2| 2| 6| 2| 6| 2| 5| 2| 2| 2| 2| 2| 2| 6| 2| 8| 9| 3|
| 8| 8| 8| 8| 6| 8| 8| 8| 8| 7| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 UG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hyperplasia | 3 2 3 3 3 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + |
C-Cell, Hyperplasia | 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + M + + |
Inflammation, Chronic Active | 3 2 |
Duct, Hyperplasia, Multifocal, | |
Squamous | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + |
Periovarian Tissue, Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + |
Endometrium, Hyperplasia, Cystic, | |
Glandular, Multifocal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Lumbar, Cyst | |
Lumbar, Inflammation, Chronic Active,| |
Multifocal | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + |
Hyperplasia, Lymphoid, Multifocal | |
__________________________________________________________________________|
Spleen | + + + + + + + + |
Degeneration, Fatty, Focal | 3 |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic, Multifocal | 4 3 3 3 3 3 4 3 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + |
Acanthosis, Multifocal | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active, Diffuse | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 5| 6| 7|
DAY ON TEST | 2| 2| 2| 2| 0| 2| 2| 2| 2| 6| 2| 6| 2| 5| 2| 2| 2| 2| 2| 2| 6| 2| 8| 9| 3|
| 8| 8| 8| 8| 6| 8| 8| 8| 8| 7| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 UG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + |
Compression | X |
Ventricle, Hydrocephalus | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + |
Foreign Body, Multifocal | |
Alveolar Epithelium, Hyperplasia | 2 |
Interstitium, Inflammation, Chronic | |
Active, Multifocal | 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Lens, Cataract | 3 4 4 |
Retina, Atrophy, Diffuse | 4 4 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hydronephrosis | 3 |
Mineralization, Multifocal | 3 |
Nephropathy, Chronic, Diffuse | 1 1 1 2 1 2 1 4 2 1 1 1 1 1 1 1 2 1 1 2 3 2|
Cortex, Hemorrhage, Focal | |
Renal Tubule, Epithelium, | |
Cytoplasmic Alteration, Focal | |
Renal Tubule, Epithelium, | |
Degeneration, Multifocal | 2 2 2 3 2 2 2 2 2 2 2 1 2 1 1 2 2 2 2 1 2 2 2 2 2|
Renal Tubule, Epithelium, | |
Hyperplasia, Focal | 2 2 2 2 |
Renal Tubule, Epithelium, | |
Hyperplasia, Multifocal | 2 2 2 2 2 2 |
Renal Tubule, Epithelium, | |
Karyomegaly, Multifocal | 2 2 2 2 2 2 2 2 2 1 2 1 2 1 1 2 2 2 3 2 2 2 2 2 2|
Renal Tubule, Epithelium, | |
Proliferation, Focal | |
Renal Tubule, Epithelium, | |
Proliferation, Multifocal | 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + |
Calculus Gross Observation | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 5| 6| 7|
DAY ON TEST | 2| 2| 2| 2| 0| 2| 2| 2| 2| 6| 2| 6| 2| 5| 2| 2| 2| 2| 2| 2| 6| 2| 8| 9| 3|
| 8| 8| 8| 8| 6| 8| 8| 8| 8| 7| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 UG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Ectasia | 4 |
Mucosa, Hyperplasia, Diffuse | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 3| 7| 7| 7| 4| 7| 6| 7| 7| 3| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 6| 3| 2| 3| 3| 7| 3| 9| 3| 3| 3| 3| 3| 3| 6| 3| 0|
| 0| 7| 0| 0| 9| 0| 0| 0| 6| 0| 2| 0| 1| 0| 1| 5| 1| 1| 1| 1| 1| 1| 4| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 UG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + +|
Basophilic Focus, Multiple | X X X X|
Cytoplasmic Alteration, Focal | 3 |
Inflammation, Chronic Active, | |
Multifocal | 2 |
Bile Duct, Hyperplasia, Multifocal | |
Centrilobular, Vacuolization | |
Cytoplasmic, Diffuse | 2 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + A + + +|
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + +|
__________________________________________________________________________|
Tongue | |
Epithelium, Hyperkeratosis, Focal | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + +|
Degeneration, Chronic, Multifocal | 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Degeneration, Fatty, Focal | 2 |
Degeneration, Fatty | 4 2 2 |
Necrosis, Acute | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 3| 7| 7| 7| 4| 7| 6| 7| 7| 3| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 6| 3| 2| 3| 3| 7| 3| 9| 3| 3| 3| 3| 3| 3| 6| 3| 0|
| 0| 7| 0| 0| 9| 0| 0| 0| 6| 0| 2| 0| 1| 0| 1| 5| 1| 1| 1| 1| 1| 1| 4| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 UG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Cyst | X X X X X|
Pars Distalis, Hyperplasia | 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + M + + + + +|
Inflammation, Chronic Active | |
Duct, Hyperplasia, Multifocal, | |
Squamous | |
__________________________________________________________________________|
Ovary | + + + + + + + + + +|
Periovarian Tissue, Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic, | |
Glandular, Multifocal | 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + +|
Lumbar, Cyst | X |
Lumbar, Inflammation, Chronic Active,| |
Multifocal | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + +|
Hyperplasia, Lymphoid, Multifocal | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + +|
Degeneration, Fatty, Focal | |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 3 |
__________________________________________________________________________|
Thymus | M M + + M M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + + + + + + + +|
Hyperplasia, Cystic, Multifocal | 3 2 3 4 3 2 2|
__________________________________________________________________________|
Skin | + + + + + + + +|
Acanthosis, Multifocal | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active, Diffuse | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 3| 7| 7| 7| 4| 7| 6| 7| 7| 3| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 6| 3| 2| 3| 3| 7| 3| 9| 3| 3| 3| 3| 3| 3| 6| 3| 0|
| 0| 7| 0| 0| 9| 0| 0| 0| 6| 0| 2| 0| 1| 0| 1| 5| 1| 1| 1| 1| 1| 1| 4| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 UG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + +|
Compression | X |
Ventricle, Hydrocephalus | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + +|
Foreign Body, Multifocal | 2 |
Alveolar Epithelium, Hyperplasia | |
Interstitium, Inflammation, Chronic | |
Active, Multifocal | 2 3 3 3 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 3 3 |
Retina, Atrophy, Diffuse | 4 3 |
__________________________________________________________________________|
Harderian Gland | + + + + M + + +|
__________________________________________________________________________|
Zymbal's Gland | + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hydronephrosis | |
Mineralization, Multifocal | |
Nephropathy, Chronic, Diffuse | 1 2 1 1 1 1 1 1 2 1 2 2 2 3 1 3 1 1 2 1 1 1 |
Cortex, Hemorrhage, Focal | 3 |
Renal Tubule, Epithelium, | |
Cytoplasmic Alteration, Focal | 2 |
Renal Tubule, Epithelium, | |
Degeneration, Multifocal | 2 1 1 2 1 2 2 1 1 2 2 2 2 2 2 2 2 2 2 2 1 1 2 2|
Renal Tubule, Epithelium, | |
Hyperplasia, Focal | 2 2 |
Renal Tubule, Epithelium, | |
Hyperplasia, Multifocal | |
Renal Tubule, Epithelium, | |
Karyomegaly, Multifocal | 2 1 1 2 1 2 2 1 1 2 2 2 2 2 2 2 2 2 2 2 2 1 1 2 2|
Renal Tubule, Epithelium, | |
Proliferation, Focal | 2 |
Renal Tubule, Epithelium, | |
Proliferation, Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + +|
Calculus Gross Observation | X |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 3| 7| 7| 7| 4| 7| 6| 7| 7| 3| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 6| 3| 2| 3| 3| 7| 3| 9| 3| 3| 3| 3| 3| 3| 6| 3| 0|
| 0| 7| 0| 0| 9| 0| 0| 0| 6| 0| 2| 0| 1| 0| 1| 5| 1| 1| 1| 1| 1| 1| 4| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 UG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Ectasia | 4 |
Mucosa, Hyperplasia, Diffuse | 4 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
70 UG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | |
__________________________________________________________________________|
Intestine Large | |
__________________________________________________________________________|
Intestine Large, Cecum | |
__________________________________________________________________________|
Intestine Large, Colon | |
__________________________________________________________________________|
Intestine Large, Rectum | |
__________________________________________________________________________|
Intestine Small | |
__________________________________________________________________________|
Intestine Small, Duodenum | |
__________________________________________________________________________|
Intestine Small, Ileum | |
__________________________________________________________________________|
Intestine Small, Jejunum | |
__________________________________________________________________________|
Liver | |
Basophilic Focus, Multiple | |
Cytoplasmic Alteration, Focal | |
Inflammation, Chronic Active, | |
Multifocal | |
Bile Duct, Hyperplasia, Multifocal | |
Centrilobular, Vacuolization | |
Cytoplasmic, Diffuse | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | |
__________________________________________________________________________|
Stomach | |
__________________________________________________________________________|
Stomach, Forestomach | |
__________________________________________________________________________|
Stomach, Glandular | |
__________________________________________________________________________|
Tongue | |
Epithelium, Hyperkeratosis, Focal | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | |
Degeneration, Chronic, Multifocal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | |
__________________________________________________________________________|
Adrenal Gland, Cortex | |
Accessory Adrenal Cortical Nodule | |
Degeneration, Fatty, Focal | |
Degeneration, Fatty | |
Necrosis, Acute | |
__________________________________________________________________________|
Adrenal Gland, Medulla | |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | |
__________________________________________________________________________|
Parathyroid Gland | |
__________________________________________________________________________|
Pituitary Gland | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
70 UG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | |
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Inflammation, Chronic Active | |
Duct, Hyperplasia, Multifocal, | |
Squamous | |
__________________________________________________________________________|
Ovary | |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | |
Endometrium, Hyperplasia, Cystic, | |
Glandular, Multifocal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | |
__________________________________________________________________________|
Lymph Node | |
Lumbar, Cyst | |
Lumbar, Inflammation, Chronic Active,| |
Multifocal | |
__________________________________________________________________________|
Lymph Node, Mandibular | |
Hyperplasia, Lymphoid, Multifocal | |
__________________________________________________________________________|
Spleen | |
Degeneration, Fatty, Focal | |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | |
__________________________________________________________________________|
Thymus | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | |
Hyperplasia, Cystic, Multifocal | |
__________________________________________________________________________|
Skin | |
Acanthosis, Multifocal | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active, Diffuse | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
70 UG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | |
Compression | |
Ventricle, Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | |
Foreign Body, Multifocal | |
Alveolar Epithelium, Hyperplasia | |
Interstitium, Inflammation, Chronic | |
Active, Multifocal | |
__________________________________________________________________________|
Nose | |
__________________________________________________________________________|
Trachea | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Atrophy, Diffuse | |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | |
Cyst | |
Hydronephrosis | |
Mineralization, Multifocal | |
Nephropathy, Chronic, Diffuse | |
Cortex, Hemorrhage, Focal | |
Renal Tubule, Epithelium, | |
Cytoplasmic Alteration, Focal | |
Renal Tubule, Epithelium, | |
Degeneration, Multifocal | |
Renal Tubule, Epithelium, | |
Hyperplasia, Focal | |
Renal Tubule, Epithelium, | |
Hyperplasia, Multifocal | |
Renal Tubule, Epithelium, | |
Karyomegaly, Multifocal | |
Renal Tubule, Epithelium, | |
Proliferation, Focal | |
Renal Tubule, Epithelium, | |
Proliferation, Multifocal | |
__________________________________________________________________________|
Urinary Bladder | |
Calculus Gross Observation | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
70 UG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Ectasia | |
Mucosa, Hyperplasia, Diffuse | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| | A |
70 UG/KG | 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 15 |
__________________________________________________________________________|____________|
Intestine Large | | 15 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 14 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 15 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 14 |
__________________________________________________________________________|____________|
Intestine Small | | 15 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 14 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 14 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 15 |
__________________________________________________________________________|____________|
Liver | | 19 |
Basophilic Focus, Multiple | | 11 |
Cytoplasmic Alteration, Focal | | 2 2.5|
Inflammation, Chronic Active, | | |
Multifocal | | 2 2.0|
Bile Duct, Hyperplasia, Multifocal | | 2 2.5|
Centrilobular, Vacuolization | | |
Cytoplasmic, Diffuse | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 14 |
Acinus, Atrophy | | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | | 15 |
__________________________________________________________________________|____________|
Stomach | | 15 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 15 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 15 |
__________________________________________________________________________|____________|
Tongue | | 1 |
Epithelium, Hyperkeratosis, Focal | | 1 2.0|
Epithelium, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 15 |
Degeneration, Chronic, Multifocal | | 9 2.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 16 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 15 |
Accessory Adrenal Cortical Nodule | | 1 |
Degeneration, Fatty, Focal | | 1 2.0|
Degeneration, Fatty | | 5 2.4|
Necrosis, Acute | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| | A |
70 UG/KG | 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 15 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 14 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 13 |
__________________________________________________________________________|____________|
Pituitary Gland | | 35 |
Pars Distalis, Cyst | | 9 |
Pars Distalis, Hyperplasia | | 8 2.9|
__________________________________________________________________________|____________|
Thyroid Gland | | 18 |
C-Cell, Hyperplasia | | 9 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 17 |
Inflammation, Chronic Active | | 2 2.5|
Duct, Hyperplasia, Multifocal, | | |
Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | | 19 |
Periovarian Tissue, Cyst | | 4 |
__________________________________________________________________________|____________|
Uterus | | 19 |
Endometrium, Hyperplasia, Cystic, | | |
Glandular, Multifocal | | 2 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 15 |
__________________________________________________________________________|____________|
Lymph Node | | 16 |
Lumbar, Cyst | | 1 |
Lumbar, Inflammation, Chronic Active,| | |
Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 15 |
Hyperplasia, Lymphoid, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | | 16 |
Degeneration, Fatty, Focal | | 1 3.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | | 2 3.0|
__________________________________________________________________________|____________|
Thymus | | 11 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| | A |
70 UG/KG | 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 34 |
Hyperplasia, Cystic, Multifocal | | 17 3.0|
__________________________________________________________________________|____________|
Skin | | 16 |
Acanthosis, Multifocal | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active, Diffuse | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 15 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 15 |
Compression | | 2 |
Ventricle, Hydrocephalus | | 2 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 18 |
Foreign Body, Multifocal | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Interstitium, Inflammation, Chronic | | |
Active, Multifocal | | 8 2.6|
__________________________________________________________________________|____________|
Nose | | 15 |
__________________________________________________________________________|____________|
Trachea | | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 5 |
Lens, Cataract | | 5 3.4|
Retina, Atrophy, Diffuse | | 5 3.8|
__________________________________________________________________________|____________|
Harderian Gland | | 14 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Cyst | | 1 |
Hydronephrosis | | 1 3.0|
Mineralization, Multifocal | | 1 3.0|
Nephropathy, Chronic, Diffuse | | 44 1.5|
Cortex, Hemorrhage, Focal | | 1 3.0|
Renal Tubule, Epithelium, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| | A |
70 UG/KG | 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Cytoplasmic Alteration, Focal | | 1 2.0|
Renal Tubule, Epithelium, | | |
Degeneration, Multifocal | | 49 1.8|
Renal Tubule, Epithelium, | | |
Hyperplasia, Focal | | 6 2.0|
Renal Tubule, Epithelium, | | |
Hyperplasia, Multifocal | | 6 2.0|
Renal Tubule, Epithelium, | | |
Karyomegaly, Multifocal | | 50 1.8|
Renal Tubule, Epithelium, | | |
Proliferation, Focal | | 1 2.0|
Renal Tubule, Epithelium, | | |
Proliferation, Multifocal | | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 15 |
Calculus Gross Observation | | 1 |
Ectasia | | 2 4.0|
Mucosa, Hyperplasia, Diffuse | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3|
DAY ON TEST | 2| 2| 2| 2| 2| 6| 2| 2| 1| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 3| 2| 2| 3| 0|
| 8| 8| 8| 8| 0| 8| 8| 1| 3| 8| 8| 8| 8| 0| 9| 9| 9| 9| 9| 9| 0| 9| 9| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
210 UG/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | X X X X X X X X X X X X X X X X X X X X X X |
Cytoplasmic Alteration, Focal | 2 2 2 |
Cytoplasmic Alteration, Multifocal | |
Eosinophilic Focus | |
Inflammation, Chronic Active, | |
Multifocal | 2 3 2 |
Necrosis, Acute | 4 |
Regeneration, Focal | 3 |
Bile Duct, Hyperplasia, Multifocal | 2 2 3 2 2 2 2 2 2 2 2 |
Periportal, Fibrosis, Chronic, | |
Multifocal | 3 |
Periportal, Vacuolization | |
Cytoplasmic, Diffuse | 2 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 4 2 2 2 2 2 |
Acinus, Focal Cellular Change | |
Duct, Ectasia | 2 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic, Multifocal | 2 3 3 2 3 2 3 2 3 2 2 2 3 2 2 3 2 3 2 3 2 3 2 |
Epicardium, Inflammation, Chronic, | |
Multifocal | 3|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3|
DAY ON TEST | 2| 2| 2| 2| 2| 6| 2| 2| 1| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 3| 2| 2| 3| 0|
| 8| 8| 8| 8| 0| 8| 8| 1| 3| 8| 8| 8| 8| 0| 9| 9| 9| 9| 9| 9| 0| 9| 9| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
210 UG/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | |
Degeneration, Fatty | 2 2 2 2 |
Hyperplasia | 2 2 2 2 2 2 |
Hypertrophy | 2 2 |
Necrosis, Acute | 3 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + M + + + + + + + + + + + + + + M + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + I + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X X X X X X X X X|
Pars Distalis, Hyperplasia | 3 3 3 3 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 3 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 2 |
Inflammation, Chronic Active | 2 2 3 2 3 |
Duct, Cyst | X |
Duct, Hyperplasia, Multifocal, | |
Squamous | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema, Diffuse | 4 |
Follicle, Cyst | |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic, | |
Glandular, Multifocal | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Reticulum Cell | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric, Hyperplasia, Lymphoid, | |
Multifocal | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3|
DAY ON TEST | 2| 2| 2| 2| 2| 6| 2| 2| 1| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 3| 2| 2| 3| 0|
| 8| 8| 8| 8| 0| 8| 8| 1| 3| 8| 8| 8| 8| 0| 9| 9| 9| 9| 9| 9| 0| 9| 9| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
210 UG/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema, Diffuse | 4 |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia, Cystic, Multifocal | 3 3 4 2 3 2 4 4 3 4 3 3 3 3 4 4 4 4 3 3 2 4 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Osteopetrosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
Ventricle, Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body, Multifocal | |
Alveolar Epithelium, Hyperplasia | 3 |
Interstitium, Inflammation, Chronic | |
Active, Multifocal | 1 1 2 3 2 3 2 4 1 2 1 2 2 |
Perivascular, Edema, Acute | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Foreign Body | 3 3 |
Mucosa, Inflammation, Acute, | |
Multifocal | 2 3 2|
Mucosa, Inflammation, Chronic Active,| |
Multifocal | |
Nasolacrimal Duct, Inflammation, | |
Acute, Multifocal | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Lens, Cataract | 4 3 4 |
Retina, Atrophy, Diffuse | 4 4 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3|
DAY ON TEST | 2| 2| 2| 2| 2| 6| 2| 2| 1| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 3| 2| 2| 3| 0|
| 8| 8| 8| 8| 0| 8| 8| 1| 3| 8| 8| 8| 8| 0| 9| 9| 9| 9| 9| 9| 0| 9| 9| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
210 UG/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X X X X X |
Cyst, Multiple | X X X |
Nephropathy, Chronic, Diffuse | 3 2 2 4 1 3 2 2 3 2 2 2 2 2 1 2 1 2 2 3 2 2 |
Pelvis, Epithelium, Hyperplasia, | |
Multifocal | |
Renal Tubule, Epithelium, | |
Cytoplasmic Alteration, Focal | 2 2 |
Renal Tubule, Epithelium, | |
Degeneration, Multifocal | 3 3 3 3 2 3 3 3 3 3 3 3 3 2 3 3 3 3 3 3 3 3 3 3 2|
Renal Tubule, Epithelium, | |
Hyperplasia, Focal | 2 2 2 2 2 2 |
Renal Tubule, Epithelium, | |
Hyperplasia, Multifocal | 2 |
Renal Tubule, Epithelium, | |
Karyomegaly, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Renal Tubule, Epithelium, | |
Proliferation, Focal | 2 2 2 2 |
Renal Tubule, Epithelium, | |
Proliferation, Multifocal | 2 2 2 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia, Diffuse | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 4| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 4| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 3| 3| 4| 3| 3| 3| 3| 6| 1| 3| 3|
| 0| 0| 9| 0| 0| 6| 0| 6| 0| 0| 0| 9| 0| 1| 1| 1| 5| 1| 1| 1| 1| 0| 5| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
210 UG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + M|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | X X X X X X X X X X X X X X X X X X X X X X X|
Cytoplasmic Alteration, Focal | 2 |
Cytoplasmic Alteration, Multifocal | 2 |
Eosinophilic Focus | X |
Inflammation, Chronic Active, | |
Multifocal | 2 2 2 2 2 |
Necrosis, Acute | |
Regeneration, Focal | |
Bile Duct, Hyperplasia, Multifocal | 2 2 2 2 3 3 3|
Periportal, Fibrosis, Chronic, | |
Multifocal | |
Periportal, Vacuolization | |
Cytoplasmic, Diffuse | |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 2 2 2 2 |
Acinus, Focal Cellular Change | X|
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | |
__________________________________________________________________________|
Stomach | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic, Multifocal | 2 2 3 2 2 2 2 3 2 2 2 2 2 2 3 2 2 2 |
Epicardium, Inflammation, Chronic, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 4| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 4| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 3| 3| 4| 3| 3| 3| 3| 6| 1| 3| 3|
| 0| 0| 9| 0| 0| 6| 0| 6| 0| 0| 0| 9| 0| 1| 1| 1| 5| 1| 1| 1| 1| 0| 5| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
210 UG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | 4 |
Degeneration, Fatty | 2 3 2 2 2 2 2 2 2|
Hyperplasia | 2 2 2 2 2 2 2 |
Hypertrophy | 2 |
Necrosis, Acute | 4 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M M + + + + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X X X X|
Pars Distalis, Hyperplasia | 3 2 3 3 3 2 3 3 3 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 2 |
Inflammation, Chronic Active | 2 |
Duct, Cyst | |
Duct, Hyperplasia, Multifocal, | |
Squamous | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema, Diffuse | |
Follicle, Cyst | X X |
Periovarian Tissue, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic, | |
Glandular, Multifocal | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Reticulum Cell | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric, Hyperplasia, Lymphoid, | |
Multifocal | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 4| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 4| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 3| 3| 4| 3| 3| 3| 3| 6| 1| 3| 3|
| 0| 0| 9| 0| 0| 6| 0| 6| 0| 0| 0| 9| 0| 1| 1| 1| 5| 1| 1| 1| 1| 0| 5| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
210 UG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema, Diffuse | |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 3 3 3 3 |
__________________________________________________________________________|
Thymus | + I + + M + + + + M + + + + + + + + + I + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic, Multifocal | 3 4 4 3 4 2 3 2 2 3 3 4 2 4 4 4 3 3 3 3 3 4 2 3 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 2 |
Ventricle, Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body, Multifocal | 1 2 |
Alveolar Epithelium, Hyperplasia | 2 3 2 |
Interstitium, Inflammation, Chronic | |
Active, Multifocal | 1 1 1 3 2 1 1 4 2 3 1 |
Perivascular, Edema, Acute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Foreign Body | 2 2 2 2 |
Mucosa, Inflammation, Acute, | |
Multifocal | 3 2 |
Mucosa, Inflammation, Chronic Active,| |
Multifocal | 2 3 |
Nasolacrimal Duct, Inflammation, | |
Acute, Multifocal | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 3 |
Retina, Atrophy, Diffuse | 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 4| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 4| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 3| 3| 4| 3| 3| 3| 3| 6| 1| 3| 3|
| 0| 0| 9| 0| 0| 6| 0| 6| 0| 0| 0| 9| 0| 1| 1| 1| 5| 1| 1| 1| 1| 0| 5| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
210 UG/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X X X X X X X X|
Cyst, Multiple | X X X |
Nephropathy, Chronic, Diffuse | 2 1 2 1 1 1 1 2 2 1 2 1 1 1 2 1 1 2 3 3 2 2 2 2|
Pelvis, Epithelium, Hyperplasia, | |
Multifocal | 2 3 |
Renal Tubule, Epithelium, | |
Cytoplasmic Alteration, Focal | |
Renal Tubule, Epithelium, | |
Degeneration, Multifocal | 3 3 3 3 3 2 3 3 3 2 4 3 3 2 3 3 3 3 3 3 3 3 2 3|
Renal Tubule, Epithelium, | |
Hyperplasia, Focal | 2 2 2 2 2 2 |
Renal Tubule, Epithelium, | |
Hyperplasia, Multifocal | |
Renal Tubule, Epithelium, | |
Karyomegaly, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Renal Tubule, Epithelium, | |
Proliferation, Focal | 2 2 2 |
Renal Tubule, Epithelium, | |
Proliferation, Multifocal | 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia, Diffuse | 3 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
210 UG/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | |
__________________________________________________________________________|
Intestine Large | |
__________________________________________________________________________|
Intestine Large, Cecum | |
__________________________________________________________________________|
Intestine Large, Colon | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | |
__________________________________________________________________________|
Intestine Small, Duodenum | |
__________________________________________________________________________|
Intestine Small, Ileum | |
__________________________________________________________________________|
Intestine Small, Jejunum | |
__________________________________________________________________________|
Liver | |
Basophilic Focus, Multiple | |
Cytoplasmic Alteration, Focal | |
Cytoplasmic Alteration, Multifocal | |
Eosinophilic Focus | |
Inflammation, Chronic Active, | |
Multifocal | |
Necrosis, Acute | |
Regeneration, Focal | |
Bile Duct, Hyperplasia, Multifocal | |
Periportal, Fibrosis, Chronic, | |
Multifocal | |
Periportal, Vacuolization | |
Cytoplasmic, Diffuse | |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | |
Acinus, Atrophy | |
Acinus, Focal Cellular Change | |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | |
Acinus, Atrophy, Focal | |
__________________________________________________________________________|
Stomach | |
__________________________________________________________________________|
Stomach, Forestomach | |
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | |
Degeneration, Chronic, Multifocal | |
Epicardium, Inflammation, Chronic, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
210 UG/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | |
__________________________________________________________________________|
Adrenal Gland, Cortex | |
Atrophy, Diffuse | |
Degeneration, Fatty | |
Hyperplasia | |
Hypertrophy | |
Necrosis, Acute | |
__________________________________________________________________________|
Adrenal Gland, Medulla | |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | |
__________________________________________________________________________|
Parathyroid Gland | |
__________________________________________________________________________|
Pituitary Gland | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | |
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Hyperplasia | |
Inflammation, Chronic Active | |
Duct, Cyst | |
Duct, Hyperplasia, Multifocal, | |
Squamous | |
__________________________________________________________________________|
Ovary | |
Edema, Diffuse | |
Follicle, Cyst | |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | |
Endometrium, Hyperplasia, Cystic, | |
Glandular, Multifocal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | |
Femoral, Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Lymph Node | |
Mesenteric, Hyperplasia, Lymphoid, | |
Multifocal | |
__________________________________________________________________________|
Lymph Node, Mandibular | |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
210 UG/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | |
Edema, Diffuse | |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | |
__________________________________________________________________________|
Thymus | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | |
Hyperplasia, Cystic, Multifocal | |
__________________________________________________________________________|
Skin | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
Femur, Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | |
Compression | |
Ventricle, Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | |
Foreign Body, Multifocal | |
Alveolar Epithelium, Hyperplasia | |
Interstitium, Inflammation, Chronic | |
Active, Multifocal | |
Perivascular, Edema, Acute | |
__________________________________________________________________________|
Nose | |
Lumen, Foreign Body | |
Mucosa, Inflammation, Acute, | |
Multifocal | |
Mucosa, Inflammation, Chronic Active,| |
Multifocal | |
Nasolacrimal Duct, Inflammation, | |
Acute, Multifocal | |
__________________________________________________________________________|
Trachea | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Atrophy, Diffuse | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
210 UG/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | |
Cyst | |
Cyst, Multiple | |
Nephropathy, Chronic, Diffuse | |
Pelvis, Epithelium, Hyperplasia, | |
Multifocal | |
Renal Tubule, Epithelium, | |
Cytoplasmic Alteration, Focal | |
Renal Tubule, Epithelium, | |
Degeneration, Multifocal | |
Renal Tubule, Epithelium, | |
Hyperplasia, Focal | |
Renal Tubule, Epithelium, | |
Hyperplasia, Multifocal | |
Renal Tubule, Epithelium, | |
Karyomegaly, Multifocal | |
Renal Tubule, Epithelium, | |
Proliferation, Focal | |
Renal Tubule, Epithelium, | |
Proliferation, Multifocal | |
__________________________________________________________________________|
Urinary Bladder | |
Mucosa, Hyperplasia, Diffuse | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| | T |
ANIMAL ID | 3| 3| 3| 3| 3| | A |
210 UG/ | 1| 1| 1| 1| 1| | L |
KG | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 48 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 47 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Small | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 49 |
__________________________________________________________________________|____________|
Liver | | 50 |
Basophilic Focus, Multiple | | 45 |
Cytoplasmic Alteration, Focal | | 4 2.0|
Cytoplasmic Alteration, Multifocal | | 1 2.0|
Eosinophilic Focus | | 1 |
Inflammation, Chronic Active, | | |
Multifocal | | 8 2.1|
Necrosis, Acute | | 1 4.0|
Regeneration, Focal | | 1 3.0|
Bile Duct, Hyperplasia, Multifocal | | 18 2.2|
Periportal, Fibrosis, Chronic, | | |
Multifocal | | 1 3.0|
Periportal, Vacuolization | | |
Cytoplasmic, Diffuse | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Acinus, Atrophy | | 14 2.1|
Acinus, Focal Cellular Change | | 1 |
Duct, Ectasia | | 3 2.0|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
Acinus, Atrophy, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 49 |
Inflammation, Chronic Active | | 1 4.0|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 49 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| | T |
ANIMAL ID | 3| 3| 3| 3| 3| | A |
210 UG/ | 1| 1| 1| 1| 1| | L |
KG | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Degeneration, Chronic, Multifocal | | 41 2.3|
Epicardium, Inflammation, Chronic, | | |
Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Atrophy, Diffuse | | 1 4.0|
Degeneration, Fatty | | 13 2.1|
Hyperplasia | | 13 2.0|
Hypertrophy | | 3 2.0|
Necrosis, Acute | | 3 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Hyperplasia | | 7 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 42 |
__________________________________________________________________________|____________|
Pituitary Gland | | 49 |
Pars Distalis, Cyst | | 17 |
Pars Distalis, Hyperplasia | | 16 2.7|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
C-Cell, Hyperplasia | | 27 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 47 |
Hyperplasia | | 8 2.3|
Inflammation, Chronic Active | | 6 2.3|
Duct, Cyst | | 1 |
Duct, Hyperplasia, Multifocal, | | |
Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | | 50 |
Edema, Diffuse | | 1 4.0|
Follicle, Cyst | | 2 |
Periovarian Tissue, Cyst | | 1 |
__________________________________________________________________________|____________|
Uterus | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| | T |
ANIMAL ID | 3| 3| 3| 3| 3| | A |
210 UG/ | 1| 1| 1| 1| 1| | L |
KG | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Endometrium, Hyperplasia, Cystic, | | |
Glandular, Multifocal | | 3 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Femoral, Hyperplasia, Reticulum Cell | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Mesenteric, Hyperplasia, Lymphoid, | | |
Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
__________________________________________________________________________|____________|
Spleen | | 50 |
Edema, Diffuse | | 1 4.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | | 5 3.0|
__________________________________________________________________________|____________|
Thymus | | 44 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 49 |
Hyperplasia, Cystic, Multifocal | | 48 3.2|
__________________________________________________________________________|____________|
Skin | | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Femur, Osteopetrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Compression | | 3 2.3|
Ventricle, Hydrocephalus | | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Foreign Body, Multifocal | | 2 1.5|
Alveolar Epithelium, Hyperplasia | | 4 2.5|
Interstitium, Inflammation, Chronic | | |
Active, Multifocal | | 24 1.9|
Perivascular, Edema, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Lumen, Foreign Body | | 6 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| | T |
ANIMAL ID | 3| 3| 3| 3| 3| | A |
210 UG/ | 1| 1| 1| 1| 1| | L |
KG | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mucosa, Inflammation, Acute, | | |
Multifocal | | 5 2.4|
Mucosa, Inflammation, Chronic Active,| | |
Multifocal | | 2 2.5|
Nasolacrimal Duct, Inflammation, | | |
Acute, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 4 |
Lens, Cataract | | 4 3.5|
Retina, Atrophy, Diffuse | | 4 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 50 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Cyst | | 25 |
Cyst, Multiple | | 6 |
Nephropathy, Chronic, Diffuse | | 46 1.9|
Pelvis, Epithelium, Hyperplasia, | | |
Multifocal | | 2 2.5|
Renal Tubule, Epithelium, | | |
Cytoplasmic Alteration, Focal | | 2 2.0|
Renal Tubule, Epithelium, | | |
Degeneration, Multifocal | | 49 2.9|
Renal Tubule, Epithelium, | | |
Hyperplasia, Focal | | 12 2.0|
Renal Tubule, Epithelium, | | |
Hyperplasia, Multifocal | | 1 2.0|
Renal Tubule, Epithelium, | | |
Karyomegaly, Multifocal | | 50 2.0|
Renal Tubule, Epithelium, | | |
Proliferation, Focal | | 7 2.0|
Renal Tubule, Epithelium, | | |
Proliferation, Multifocal | | 9 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
Mucosa, Hyperplasia, Diffuse | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 0| 7| 7| 3| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 8| 2| 2| 1| 2| 2| 7| 2| 2| 2| 2| 3| 3| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3|
| 9| 9| 6| 9| 9| 0| 9| 9| 7| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 UG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + M + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X |
Congestion | 4 |
Degeneration, Cystic, Focal | 2 |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 2 |
Inflammation, Chronic Active, | |
Multifocal | 2 2 2 2 2 2|
Necrosis, Acute | 2 |
Bile Duct, Hyperplasia, Multifocal | 3 3 2 2 2 2 3 2 3 3 2 2 2 3 3 2 3 2 2 2|
Centrilobular, Vacuolization | |
Cytoplasmic, Diffuse | 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Diffuse | 2 |
Acinus, Atrophy | 2 2 2 2 2 2 2 |
Acinus, Focal Cellular Change | X X X X X |
Acinus, Hyperplasia, Focal | 2 3 2 3 |
Duct, Ectasia, Multifocal | 2 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | |
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic, Multifocal | 3 2 2 3 3 3 2 2 2 3 3 3 2 3 1 2 3 2 3 3 3 2 2 2|
Inflammation, Chronic, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 0| 7| 7| 3| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 8| 2| 2| 1| 2| 2| 7| 2| 2| 2| 2| 3| 3| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3|
| 9| 9| 6| 9| 9| 0| 9| 9| 7| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 UG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 2 2 |
Hyperplasia | 2 2 2 2 2 2 2 2 |
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Parathyroid Gland | M + M + + M + M + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X|
Pars Distalis, Hyperplasia | 2 |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2|
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, | |
Multifocal | 2 3 2 2 2 2 2 3 2 3 3 2 2 2 2 2 3 3 2 2 3|
Duct, Ectasia | 3 3 3 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, | |
Multifocal | 2 2 2 2 2 1 2 2 3|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 4 4 3 4 4 4 4 4 4 4 3 4 4 4 4 4 3 4 4 4 3|
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Acute, Multifocal | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 0| 7| 7| 3| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 8| 2| 2| 1| 2| 2| 7| 2| 2| 2| 2| 3| 3| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3|
| 9| 9| 6| 9| 9| 0| 9| 9| 7| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 UG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Depletion Lymphoid | 3 2 2 |
Infiltration Cellular, Multifocal, | |
Lipocyte | 3 |
Red Pulp, Fibrosis | 3 2 |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + M + + + + M M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M M + + + + + + M + + + + M + + + M + + M + +|
Hyperplasia, Cystic, Multifocal | 3 3 3 3 2 2 3 2 2 3 2 3 2 2 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Subcutaneous Tissue, Inflammation, | |
Chronic Active, Diffuse | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Ventricle, Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 |
Edema, Acute, Diffuse | 3 2 3 |
Foreign Body, Multifocal | 3 3 2 3 2 2 2|
Mineralization, Focal | 2 |
Alveolar Epithelium, Hyperplasia | |
Interstitium, Inflammation, Chronic | |
Active, Multifocal | 2 2 2 2 3 3 2 3 3 3 3|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 4 4 |
Retina, Atrophy, Diffuse | 4 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 0| 7| 7| 3| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 8| 2| 2| 1| 2| 2| 7| 2| 2| 2| 2| 3| 3| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3|
| 9| 9| 6| 9| 9| 0| 9| 9| 7| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 UG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy, Chronic, Diffuse | 4 3 3 2 3 3 2 2 2 2 2 3 2 4 2 2 4 3 2 3 2 4 4|
Renal Tubule, Hyperplasia | 2 |
Renal Tubule, Epithelium, | |
Cytoplasmic Alteration, Focal | |
Renal Tubule, Epithelium, | |
Hyperplasia, Focal | |
Vein, Dilatation, Focal | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 4| 3| 9| 0| 3| 3| 1| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 1| 1| 1| 1| 6| 1| 1| 1| 0| 1| 1| 4| 1| 1| 6| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 UG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + M + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X |
Congestion | |
Degeneration, Cystic, Focal | 2 |
Hematopoietic Cell Proliferation, | |
Multifocal | |
Inflammation, Chronic Active, | |
Multifocal | 2 2 |
Necrosis, Acute | |
Bile Duct, Hyperplasia, Multifocal | 4 3 3 3 2 3 2 3 2 2 3 3 3 3 3 2 2 2 |
Centrilobular, Vacuolization | |
Cytoplasmic, Diffuse | 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Diffuse | |
Acinus, Atrophy | 2 2 2 2 3 2 2 2 2 2|
Acinus, Focal Cellular Change | X |
Acinus, Hyperplasia, Focal | 2 2 |
Duct, Ectasia, Multifocal | |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | 1 |
Inflammation, Chronic Active | 2 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic, Multifocal | 3 2 3 3 2 3 2 3 3 2 2 3 3 2 2 2 2 2 2 2 3 2 2|
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 4| 3| 9| 0| 3| 3| 1| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 1| 1| 1| 1| 6| 1| 1| 1| 0| 1| 1| 4| 1| 1| 6| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 UG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 3 2 2|
Hyperplasia | 2 2 2 3 2 2 2 2 3 2|
Hypertrophy | 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + M + M + + M M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 3 2 2 2 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, | |
Multifocal | 3 2 2 3 2 3 2 2 2 2 2 3 3 2 3 2 3 3 3 3 2 2 2 |
Duct, Ectasia | 4 3 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, | |
Multifocal | 3 2 2 3 3 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 3 4 4 4 3 4 4 4 4 3 4 4 4 3 4 3 4 4 4 3 3 3|
Interstitial Cell, Hyperplasia | 2 2 2 3 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Acute, Multifocal | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 4| 3| 9| 0| 3| 3| 1| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 1| 1| 1| 1| 6| 1| 1| 1| 0| 1| 1| 4| 1| 1| 6| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 UG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Depletion Lymphoid | |
Infiltration Cellular, Multifocal, | |
Lipocyte | |
Red Pulp, Fibrosis | |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 3 3 |
__________________________________________________________________________|
Thymus | M M + + + + + + + + I M + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + M + + M + + + + M + + + + + + +|
Hyperplasia, Cystic, Multifocal | 3 2 2 2 3 4 2 3 3 3 2 3 3 2 1 3 2 4 3 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + M + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active, Diffuse | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 |
Ventricle, Hydrocephalus | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema, Acute, Diffuse | |
Foreign Body, Multifocal | 3 3 3 2 |
Mineralization, Focal | |
Alveolar Epithelium, Hyperplasia | 2 2 3|
Interstitium, Inflammation, Chronic | |
Active, Multifocal | 3 3 3 2 3 2 3 3 2 3|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 4 |
Retina, Atrophy, Diffuse | 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 4| 3| 9| 0| 3| 3| 1| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 1| 1| 1| 1| 6| 1| 1| 1| 0| 1| 1| 4| 1| 1| 6| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 UG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy, Chronic, Diffuse | 3 3 3 3 3 4 3 1 2 3 2 4 2 3 2 3 3 2 2 2 2 2 2 2 2|
Renal Tubule, Hyperplasia | |
Renal Tubule, Epithelium, | |
Cytoplasmic Alteration, Focal | 2 |
Renal Tubule, Epithelium, | |
Hyperplasia, Focal | 2 |
Vein, Dilatation, Focal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 UG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | |
__________________________________________________________________________|
Intestine Large | |
__________________________________________________________________________|
Intestine Large, Cecum | |
__________________________________________________________________________|
Intestine Large, Colon | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | |
__________________________________________________________________________|
Intestine Small, Duodenum | |
__________________________________________________________________________|
Intestine Small, Ileum | |
__________________________________________________________________________|
Intestine Small, Jejunum | |
__________________________________________________________________________|
Liver | |
Basophilic Focus, Multiple | |
Clear Cell Focus | |
Congestion | |
Degeneration, Cystic, Focal | |
Hematopoietic Cell Proliferation, | |
Multifocal | |
Inflammation, Chronic Active, | |
Multifocal | |
Necrosis, Acute | |
Bile Duct, Hyperplasia, Multifocal | |
Centrilobular, Vacuolization | |
Cytoplasmic, Diffuse | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | |
Inflammation, Chronic, Diffuse | |
Acinus, Atrophy | |
Acinus, Focal Cellular Change | |
Acinus, Hyperplasia, Focal | |
Duct, Ectasia, Multifocal | |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | |
__________________________________________________________________________|
Stomach | |
__________________________________________________________________________|
Stomach, Forestomach | |
Acanthosis, Focal | |
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | |
Degeneration, Chronic, Multifocal | |
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 UG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | |
__________________________________________________________________________|
Adrenal Gland, Cortex | |
Degeneration, Fatty | |
Hyperplasia | |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | |
Hyperplasia, Focal | |
__________________________________________________________________________|
Parathyroid Gland | |
__________________________________________________________________________|
Pituitary Gland | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | |
C-Cell, Hyperplasia | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | |
__________________________________________________________________________|
Preputial Gland | |
Inflammation, Chronic Active, | |
Multifocal | |
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | |
Inflammation, Chronic Active, | |
Multifocal | |
__________________________________________________________________________|
Testes | |
Germinal Epithelium, Atrophy | |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | |
Necrosis, Acute, Multifocal | |
__________________________________________________________________________|
Spleen | |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 UG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Depletion Lymphoid | |
Infiltration Cellular, Multifocal, | |
Lipocyte | |
Red Pulp, Fibrosis | |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | |
__________________________________________________________________________|
Thymus | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | |
Hyperplasia, Cystic, Multifocal | |
__________________________________________________________________________|
Skin | |
Cyst Epithelial Inclusion | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active, Diffuse | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | |
Compression | |
Ventricle, Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | |
Congestion | |
Edema, Acute, Diffuse | |
Foreign Body, Multifocal | |
Mineralization, Focal | |
Alveolar Epithelium, Hyperplasia | |
Interstitium, Inflammation, Chronic | |
Active, Multifocal | |
__________________________________________________________________________|
Nose | |
__________________________________________________________________________|
Trachea | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Atrophy, Diffuse | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 UG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy, Chronic, Diffuse | |
Renal Tubule, Hyperplasia | |
Renal Tubule, Epithelium, | |
Cytoplasmic Alteration, Focal | |
Renal Tubule, Epithelium, | |
Hyperplasia, Focal | |
Vein, Dilatation, Focal | |
__________________________________________________________________________|
Urinary Bladder | |
Calculus Micro Observation Only | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| | A |
0 UG/KG | 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 48 |
Parasite Metazoan | | 6 |
__________________________________________________________________________|____________|
Intestine Small | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 50 |
__________________________________________________________________________|____________|
Liver | | 50 |
Basophilic Focus, Multiple | | 40 |
Clear Cell Focus | | 9 |
Congestion | | 1 4.0|
Degeneration, Cystic, Focal | | 2 2.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | | 2 2.0|
Inflammation, Chronic Active, | | |
Multifocal | | 8 2.0|
Necrosis, Acute | | 1 2.0|
Bile Duct, Hyperplasia, Multifocal | | 38 2.5|
Centrilobular, Vacuolization | | |
Cytoplasmic, Diffuse | | 23 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 50 |
Inflammation, Chronic, Diffuse | | 1 2.0|
Acinus, Atrophy | | 17 2.1|
Acinus, Focal Cellular Change | | 6 |
Acinus, Hyperplasia, Focal | | 6 2.3|
Duct, Ectasia, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Acanthosis, Focal | | 1 1.0|
Inflammation, Chronic Active | | 1 2.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| | A |
0 UG/KG | 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Degeneration, Chronic, Multifocal | | 47 2.4|
Inflammation, Chronic, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Degeneration, Fatty | | 6 2.2|
Hyperplasia | | 18 2.1|
Hypertrophy | | 5 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Hyperplasia | | 7 2.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 41 |
__________________________________________________________________________|____________|
Pituitary Gland | | 50 |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | | 6 2.2|
Pars Intermedia, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
C-Cell, Hyperplasia | | 24 2.0|
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 49 |
__________________________________________________________________________|____________|
Preputial Gland | | 50 |
Inflammation, Chronic Active, | | |
Multifocal | | 44 2.4|
Duct, Ectasia | | 8 3.3|
__________________________________________________________________________|____________|
Prostate | | 50 |
Inflammation, Chronic Active, | | |
Multifocal | | 15 2.2|
__________________________________________________________________________|____________|
Testes | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| | A |
0 UG/KG | 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Germinal Epithelium, Atrophy | | 43 3.7|
Interstitial Cell, Hyperplasia | | 22 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
__________________________________________________________________________|____________|
Lymph Node | | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 49 |
Necrosis, Acute, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | | 50 |
Depletion Lymphoid | | 3 2.3|
Infiltration Cellular, Multifocal, | | |
Lipocyte | | 1 3.0|
Red Pulp, Fibrosis | | 2 2.5|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | | 3 3.0|
__________________________________________________________________________|____________|
Thymus | | 41 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 39 |
Hyperplasia, Cystic, Multifocal | | 37 2.5|
__________________________________________________________________________|____________|
Skin | | 49 |
Cyst Epithelial Inclusion | | 1 |
Subcutaneous Tissue, Inflammation, | | |
Chronic Active, Diffuse | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Compression | | 1 4.0|
Ventricle, Hydrocephalus | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion | | 2 3.0|
Edema, Acute, Diffuse | | 3 2.7|
Foreign Body, Multifocal | | 11 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| | A |
0 UG/KG | 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mineralization, Focal | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 3 2.3|
Interstitium, Inflammation, Chronic | | |
Active, Multifocal | | 21 2.6|
__________________________________________________________________________|____________|
Nose | | 50 |
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
Lens, Cataract | | 3 4.0|
Retina, Atrophy, Diffuse | | 3 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 49 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Nephropathy, Chronic, Diffuse | | 48 2.6|
Renal Tubule, Hyperplasia | | 1 2.0|
Renal Tubule, Epithelium, | | |
Cytoplasmic Alteration, Focal | | 1 2.0|
Renal Tubule, Epithelium, | | |
Hyperplasia, Focal | | 1 2.0|
Vein, Dilatation, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
Calculus Micro Observation Only | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 6| 7| 5| 7|
DAY ON TEST | 2| 7| 2| 7| 8| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 1| 3| 8| 2| 3| 3| 7| 3| 5| 3|
| 9| 6| 9| 4| 0| 9| 9| 9| 7| 9| 0| 0| 0| 6| 8| 6| 0| 7| 2| 0| 0| 8| 1| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
21 UG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + |
Basophilic Focus, Multiple | X X X X X X |
Congestion | 4 |
Degeneration, Cystic, Focal | |
Inflammation, Chronic Active, | |
Multifocal | 2 |
Mixed Cell Focus | |
Necrosis, Acute | 3 |
Bile Duct, Hyperplasia, Multifocal | 2 3 2 2 2 2 |
Centrilobular, Vacuolization | |
Cytoplasmic, Diffuse | 2 3 |
Periportal, Vacuolization | |
Cytoplasmic, Diffuse | 3 |
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Chronic Active | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + |
Acinus, Atrophy | 2 2 2 3 |
Perivascular, Inflammation, Chronic | |
Active, Multifocal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + |
Acanthosis | 3 |
Inflammation, Chronic Active | 3 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + |
Inflammation, Acute | |
__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + |
Degeneration, Chronic, Multifocal | 3 3 3 2 2 2 2 2 2 3 3 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 6| 7| 5| 7|
DAY ON TEST | 2| 7| 2| 7| 8| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 1| 3| 8| 2| 3| 3| 7| 3| 5| 3|
| 9| 6| 9| 4| 0| 9| 9| 9| 7| 9| 0| 0| 0| 6| 8| 6| 0| 7| 2| 0| 0| 8| 1| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
21 UG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + |
Degeneration, Fatty | 2 |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 3 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + |
Hyperplasia | 3 |
Inflammation, Chronic Active, | |
Multifocal | 2 2 2 2 |
Duct, Ectasia | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + |
Inflammation, Acute | |
Inflammation, Chronic Active, | |
Multifocal | 2 |
__________________________________________________________________________|
Seminal Vesicle | |
Dilatation | |
Inflammation, Acute | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 4|
Interstitial Cell, Hyperplasia | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + |
Femoral, Hyperplasia, Diffuse, | |
Neutrophil | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + |
Inguinal, Sinus, Ectasia | |
Lumbar, Sinus, Ectasia | |
Mediastinal, Congestion | |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 6| 7| 5| 7|
DAY ON TEST | 2| 7| 2| 7| 8| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 1| 3| 8| 2| 3| 3| 7| 3| 5| 3|
| 9| 6| 9| 4| 0| 9| 9| 9| 7| 9| 0| 0| 0| 6| 8| 6| 0| 7| 2| 0| 0| 8| 1| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
21 UG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mesenteric, Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + |
Infiltration Cellular, Plasma Cell | 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + |
Angiectasis | |
Depletion Lymphoid | 3 3 |
Red Pulp, Fibrosis | 2 2 |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | |
__________________________________________________________________________|
Thymus | + + + + + M + + M M + M |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + M + + +|
Hyperplasia, Cystic, Multifocal | 2 3 3 3 1 3 3 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + |
Hyperkeratosis | |
Subcutaneous Tissue, Fibrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + |
Compression | X |
Ventricle, Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + |
Foreign Body, Multifocal | 2 3 3 |
Pigmentation | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Interstitium, Inflammation, Acute, | |
Multifocal | 3 |
Interstitium, Inflammation, Chronic | |
Active, Multifocal | 2 3 3 2 |
Perivascular, Edema, Acute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 3 |
Retina, Atrophy, Diffuse | 3 |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 6| 7| 5| 7|
DAY ON TEST | 2| 7| 2| 7| 8| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 1| 3| 8| 2| 3| 3| 7| 3| 5| 3|
| 9| 6| 9| 4| 0| 9| 9| 9| 7| 9| 0| 0| 0| 6| 8| 6| 0| 7| 2| 0| 0| 8| 1| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
21 UG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Multiple | X |
Hydronephrosis | |
Nephropathy, Chronic, Diffuse | 3 3 4 2 1 2 2 3 2 2 2 3 2 4 2 2 4 1 4 4 2 2 2 2 2|
Renal Tubule, Epithelium, | |
Hyperplasia, Multifocal | |
Renal Tubule, Epithelium, | |
Karyomegaly, Multifocal | 1 |
__________________________________________________________________________|
Urethra | |
Calculus Micro Observation Only | |
__________________________________________________________________________|
Urinary Bladder | + + + A + + + + + + + + |
Ectasia | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 6| 5| 7| 6| 7| 4| 7| 6| 2| 7| 6| 7| 4| 6| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 1| 3| 3| 3| 2| 5| 3| 7| 3| 1| 3| 3| 6| 1| 2| 3| 0| 8| 3| 3| 8| 3| 0|
| 1| 1| 7| 1| 1| 1| 8| 6| 2| 5| 2| 8| 2| 3| 2| 7| 4| 2| 9| 1| 2| 2| 8| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
21 UG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + +|
Basophilic Focus, Multiple | X X X X X X X |
Congestion | |
Degeneration, Cystic, Focal | 2|
Inflammation, Chronic Active, | |
Multifocal | |
Mixed Cell Focus | X |
Necrosis, Acute | 3 3 3 |
Bile Duct, Hyperplasia, Multifocal | 2 2 2 3 3 3 3 3 2 3|
Centrilobular, Vacuolization | |
Cytoplasmic, Diffuse | 2 2 3 |
Periportal, Vacuolization | |
Cytoplasmic, Diffuse | |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + +|
Acinus, Atrophy | 4 2 2 2|
Perivascular, Inflammation, Chronic | |
Active, Multifocal | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + |
Acanthosis | |
Inflammation, Chronic Active | 3 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Tongue | + + |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + +|
Degeneration, Chronic, Multifocal | 3 3 2 3 3 3 3 3 3 3 2 2 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 6| 5| 7| 6| 7| 4| 7| 6| 2| 7| 6| 7| 4| 6| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 1| 3| 3| 3| 2| 5| 3| 7| 3| 1| 3| 3| 6| 1| 2| 3| 0| 8| 3| 3| 8| 3| 0|
| 1| 1| 7| 1| 1| 1| 8| 6| 2| 5| 2| 8| 2| 3| 2| 7| 4| 2| 9| 1| 2| 2| 8| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
21 UG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + +|
Degeneration, Fatty | 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + +|
Hyperplasia | 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M A + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + A + + + + +|
C-Cell, Hyperplasia | 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active, | |
Multifocal | 2 2 2 2 2 2 2 |
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
Inflammation, Chronic Active, | |
Multifocal | 2 |
__________________________________________________________________________|
Seminal Vesicle | + |
Dilatation | 3 |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | |
Interstitial Cell, Hyperplasia | 3 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + A + + + + + + + +|
Femoral, Hyperplasia, Diffuse, | |
Neutrophil | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + +|
Inguinal, Sinus, Ectasia | 4 |
Lumbar, Sinus, Ectasia | 3 |
Mediastinal, Congestion | 3 |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 6| 5| 7| 6| 7| 4| 7| 6| 2| 7| 6| 7| 4| 6| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 1| 3| 3| 3| 2| 5| 3| 7| 3| 1| 3| 3| 6| 1| 2| 3| 0| 8| 3| 3| 8| 3| 0|
| 1| 1| 7| 1| 1| 1| 8| 6| 2| 5| 2| 8| 2| 3| 2| 7| 4| 2| 9| 1| 2| 2| 8| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
21 UG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mesenteric, Sinus, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + +|
Angiectasis | 2 |
Depletion Lymphoid | 2 3 2 |
Red Pulp, Fibrosis | |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + M M + + + + M +|
Hyperplasia, Cystic, Multifocal | 3 3 2 2 2 3 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + +|
Hyperkeratosis | 4 |
Subcutaneous Tissue, Fibrosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + A + + + +|
Compression | |
Ventricle, Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Foreign Body, Multifocal | 2 2 2 2 3 |
Pigmentation | 3 |
Alveolar Epithelium, Hyperplasia | |
Interstitium, Inflammation, Acute, | |
Multifocal | 2 |
Interstitium, Inflammation, Chronic | |
Active, Multifocal | 3 |
Perivascular, Edema, Acute | 2 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + A +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Atrophy, Diffuse | |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 6| 5| 7| 6| 7| 4| 7| 6| 2| 7| 6| 7| 4| 6| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 1| 3| 3| 3| 2| 5| 3| 7| 3| 1| 3| 3| 6| 1| 2| 3| 0| 8| 3| 3| 8| 3| 0|
| 1| 1| 7| 1| 1| 1| 8| 6| 2| 5| 2| 8| 2| 3| 2| 7| 4| 2| 9| 1| 2| 2| 8| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
21 UG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + M + + M M M +|
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Multiple | |
Hydronephrosis | 3 |
Nephropathy, Chronic, Diffuse | 2 3 2 3 3 2 2 2 3 4 4 2 3 2 2 2 3 3 2 2 2 3 1 2 2|
Renal Tubule, Epithelium, | |
Hyperplasia, Multifocal | 2 |
Renal Tubule, Epithelium, | |
Karyomegaly, Multifocal | |
__________________________________________________________________________|
Urethra | + |
Calculus Micro Observation Only | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + A + + M + + +|
Ectasia | 4 |
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
21 UG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + |
__________________________________________________________________________|
Intestine Large | + |
__________________________________________________________________________|
Intestine Large, Cecum | + |
__________________________________________________________________________|
Intestine Large, Colon | + |
__________________________________________________________________________|
Intestine Large, Rectum | + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + |
__________________________________________________________________________|
Intestine Small, Duodenum | + |
__________________________________________________________________________|
Intestine Small, Ileum | + |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
__________________________________________________________________________|
Liver | + |
Basophilic Focus, Multiple | |
Congestion | |
Degeneration, Cystic, Focal | |
Inflammation, Chronic Active, | |
Multifocal | |
Mixed Cell Focus | |
Necrosis, Acute | 3 |
Bile Duct, Hyperplasia, Multifocal | |
Centrilobular, Vacuolization | |
Cytoplasmic, Diffuse | |
Periportal, Vacuolization | |
Cytoplasmic, Diffuse | |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + |
Acinus, Atrophy | |
Perivascular, Inflammation, Chronic | |
Active, Multifocal | |
__________________________________________________________________________|
Salivary Glands | + |
__________________________________________________________________________|
Stomach | + |
__________________________________________________________________________|
Stomach, Forestomach | + |
Acanthosis | |
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + |
Inflammation, Acute | |
__________________________________________________________________________|
Tongue | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + |
Degeneration, Chronic, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
21 UG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + |
Degeneration, Fatty | |
Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + |
__________________________________________________________________________|
Parathyroid Gland | M |
__________________________________________________________________________|
Pituitary Gland | + |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + |
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + |
__________________________________________________________________________|
Preputial Gland | + |
Hyperplasia | |
Inflammation, Chronic Active, | |
Multifocal | |
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + |
Inflammation, Acute | |
Inflammation, Chronic Active, | |
Multifocal | |
__________________________________________________________________________|
Seminal Vesicle | |
Dilatation | |
Inflammation, Acute | |
__________________________________________________________________________|
Testes | + |
Germinal Epithelium, Atrophy | |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + |
Femoral, Hyperplasia, Diffuse, | |
Neutrophil | |
__________________________________________________________________________|
Lymph Node | + |
Inguinal, Sinus, Ectasia | |
Lumbar, Sinus, Ectasia | |
Mediastinal, Congestion | |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
21 UG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mesenteric, Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + |
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Spleen | + |
Angiectasis | |
Depletion Lymphoid | |
Red Pulp, Fibrosis | |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | |
__________________________________________________________________________|
Thymus | + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + |
Hyperplasia, Cystic, Multifocal | 2 |
__________________________________________________________________________|
Skin | + |
Hyperkeratosis | |
Subcutaneous Tissue, Fibrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + |
Compression | |
Ventricle, Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + |
Foreign Body, Multifocal | 3 |
Pigmentation | |
Alveolar Epithelium, Hyperplasia | |
Interstitium, Inflammation, Acute, | |
Multifocal | |
Interstitium, Inflammation, Chronic | |
Active, Multifocal | |
Perivascular, Edema, Acute | 3 |
__________________________________________________________________________|
Nose | + |
__________________________________________________________________________|
Trachea | + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Atrophy, Diffuse | |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
21 UG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + |
Cyst, Multiple | |
Hydronephrosis | |
Nephropathy, Chronic, Diffuse | 1 |
Renal Tubule, Epithelium, | |
Hyperplasia, Multifocal | |
Renal Tubule, Epithelium, | |
Karyomegaly, Multifocal | |
__________________________________________________________________________|
Urethra | |
Calculus Micro Observation Only | |
__________________________________________________________________________|
Urinary Bladder | + |
Ectasia | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| | A |
21 UG/KG | 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 26 |
__________________________________________________________________________|____________|
Intestine Large | | 26 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 23 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 25 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 23 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Small | | 26 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 25 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 24 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 25 |
__________________________________________________________________________|____________|
Liver | | 26 |
Basophilic Focus, Multiple | | 13 |
Congestion | | 1 4.0|
Degeneration, Cystic, Focal | | 1 2.0|
Inflammation, Chronic Active, | | |
Multifocal | | 1 2.0|
Mixed Cell Focus | | 1 |
Necrosis, Acute | | 5 3.0|
Bile Duct, Hyperplasia, Multifocal | | 16 2.4|
Centrilobular, Vacuolization | | |
Cytoplasmic, Diffuse | | 5 2.4|
Periportal, Vacuolization | | |
Cytoplasmic, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 7 |
Inflammation, Chronic Active | | 3 3.0|
__________________________________________________________________________|____________|
Pancreas | | 26 |
Acinus, Atrophy | | 8 2.4|
Perivascular, Inflammation, Chronic | | |
Active, Multifocal | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | | 26 |
__________________________________________________________________________|____________|
Stomach | | 26 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 25 |
Acanthosis | | 1 3.0|
Inflammation, Chronic Active | | 2 3.0|
Ulcer | | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 25 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 3 |
Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| | A |
21 UG/KG | 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 26 |
Degeneration, Chronic, Multifocal | | 26 2.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 25 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 25 |
Degeneration, Fatty | | 2 2.0|
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 25 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 26 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 21 |
__________________________________________________________________________|____________|
Pituitary Gland | | 33 |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | | 4 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 29 |
C-Cell, Hyperplasia | | 6 2.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 26 |
__________________________________________________________________________|____________|
Preputial Gland | | 28 |
Hyperplasia | | 1 3.0|
Inflammation, Chronic Active, | | |
Multifocal | | 11 2.0|
Duct, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Prostate | | 26 |
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic Active, | | |
Multifocal | | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 1 |
Dilatation | | 1 3.0|
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Testes | | 50 |
Germinal Epithelium, Atrophy | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| | A |
21 UG/KG | 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Interstitial Cell, Hyperplasia | | 13 2.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 25 |
Femoral, Hyperplasia, Diffuse, | | |
Neutrophil | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 28 |
Inguinal, Sinus, Ectasia | | 1 4.0|
Lumbar, Sinus, Ectasia | | 1 3.0|
Mediastinal, Congestion | | 1 3.0|
Mesenteric, Sinus, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 28 |
Infiltration Cellular, Plasma Cell | | 3 2.7|
__________________________________________________________________________|____________|
Spleen | | 29 |
Angiectasis | | 1 2.0|
Depletion Lymphoid | | 5 2.6|
Red Pulp, Fibrosis | | 2 2.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | | 22 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 22 |
Hyperplasia, Cystic, Multifocal | | 18 2.4|
__________________________________________________________________________|____________|
Skin | | 32 |
Hyperkeratosis | | 1 4.0|
Subcutaneous Tissue, Fibrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 26 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 25 |
Compression | | 1 |
Ventricle, Hydrocephalus | | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 30 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| | A |
21 UG/KG | 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Foreign Body, Multifocal | | 9 2.4|
Pigmentation | | 2 2.5|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Interstitium, Inflammation, Acute, | | |
Multifocal | | 2 2.5|
Interstitium, Inflammation, Chronic | | |
Active, Multifocal | | 5 2.6|
Perivascular, Edema, Acute | | 4 2.5|
__________________________________________________________________________|____________|
Nose | | 25 |
__________________________________________________________________________|____________|
Trachea | | 26 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Lens, Cataract | | 1 3.0|
Retina, Atrophy, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 22 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 51 |
Cyst, Multiple | | 1 |
Hydronephrosis | | 1 3.0|
Nephropathy, Chronic, Diffuse | | 51 2.4|
Renal Tubule, Epithelium, | | |
Hyperplasia, Multifocal | | 1 2.0|
Renal Tubule, Epithelium, | | |
Karyomegaly, Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
Calculus Micro Observation Only | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | | 23 |
Ectasia | | 1 4.0|
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 5| 0| 2| 2| 2| 2| 2| 5| 4| 8| 3| 3| 3| 3| 1| 0| 3| 3| 1| 1| 3|
| 9| 9| 4| 9| 9| 6| 0| 9| 9| 9| 9| 4| 6| 1| 0| 0| 0| 0| 6| 7| 0| 0| 2| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
70 UG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | A + + A + + + + + + + |
Inflammation, Chronic Active, Diffuse| |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + |
Basophilic Focus, Multiple | X X X X |
Cytoplasmic Alteration, Focal | 3 |
Degeneration, Cystic, Focal | 2 |
Necrosis, Acute | 2 |
Bile Duct, Hyperplasia, Multifocal | 2 2 3 2 3 3 3 |
Centrilobular, Vacuolization | |
Cytoplasmic, Diffuse | 2 |
Periportal, Vacuolization | |
Cytoplasmic, Diffuse | 2 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + |
Acinus, Atrophy | |
Acinus, Hyperplasia, Focal | 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + |
Inflammation, Chronic Active | 1 3 |
Ulcer | 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + |
Degeneration, Chronic, Multifocal | 3 2 3 3 2 3 3 3 2 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | M + + + + + + + + + + |
Cytoplasmic Alteration | 2 |
Degeneration, Fatty | 2 |
Hyperplasia | 1 |
Hypertrophy | 2 |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 5| 0| 2| 2| 2| 2| 2| 5| 4| 8| 3| 3| 3| 3| 1| 0| 3| 3| 1| 1| 3|
| 9| 9| 4| 9| 9| 6| 0| 9| 9| 9| 9| 4| 6| 1| 0| 0| 0| 0| 6| 7| 0| 0| 2| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
70 UG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Bilateral, Atrophy, Diffuse | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + A + + + + + + + + |
C-Cell, Hyperplasia | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + |
Atrophy, Diffuse | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + |
Hyperplasia | 3 |
Inflammation, Chronic Active, | |
Multifocal | 2 2 3 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + |
Atrophy, Diffuse | 3 |
Epithelium, Hyperplasia, Multifocal | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 4 4 4 4 4 3 4 4 4 4 3 3 4 4 2 3 3 3 4 3 4|
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + |
Red Pulp, Fibrosis | |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | |
__________________________________________________________________________|
Thymus | + M + M + M + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + |
Hyperplasia, Cystic, Multifocal | 2 3 2 2 1 3 3 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 5| 0| 2| 2| 2| 2| 2| 5| 4| 8| 3| 3| 3| 3| 1| 0| 3| 3| 1| 1| 3|
| 9| 9| 4| 9| 9| 6| 0| 9| 9| 9| 9| 4| 6| 1| 0| 0| 0| 0| 6| 7| 0| 0| 2| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
70 UG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + |
Compression | X |
Ventricle, Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + |
Congestion | 3 |
Foreign Body, Multifocal | 2 3 |
Alveolar Epithelium, Hyperplasia | |
Interstitium, Inflammation, Acute, | |
Multifocal | |
Interstitium, Inflammation, Chronic | |
Active, Multifocal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + |
Nasolacrimal Duct, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 3 |
Retina, Atrophy, Diffuse | 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + M + + M + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Nephropathy, Chronic, Diffuse | 3 3 3 3 2 2 1 4 3 3 3 2 1 2 4 4 3 4 2 2 2 4 1 4 3|
Renal Tubule, Epithelium, | |
Cytoplasmic Alteration, Focal | 2 3 |
Renal Tubule, Epithelium, | |
Cytoplasmic Alteration, | |
Multifocal | 2 |
Renal Tubule, Epithelium, | |
Degeneration, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2|
Renal Tubule, Epithelium, | |
Hyperplasia, Focal | 2 3 2 2 2 2|
Renal Tubule, Epithelium, | |
Hyperplasia, Multifocal | 2 |
Renal Tubule, Epithelium, | |
Karyomegaly, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 5| 0| 2| 2| 2| 2| 2| 5| 4| 8| 3| 3| 3| 3| 1| 0| 3| 3| 1| 1| 3|
| 9| 9| 4| 9| 9| 6| 0| 9| 9| 9| 9| 4| 6| 1| 0| 0| 0| 0| 6| 7| 0| 0| 2| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
70 UG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Epithelium, | |
Proliferation, Focal | 2 2 |
Renal Tubule, Epithelium, | |
Proliferation, Multifocal | 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + A + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 2| 6| 7| 6| 7| 2| 7| 7| 7| 7| 5|
DAY ON TEST | 6| 3| 3| 0| 3| 3| 4| 7| 3| 3| 3| 6| 3| 4| 9| 9| 1| 7| 3| 9| 3| 3| 3| 1| 8|
| 1| 1| 1| 9| 1| 1| 4| 2| 1| 2| 2| 9| 2| 0| 7| 1| 6| 4| 2| 0| 2| 2| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
70 UG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + +|
Inflammation, Chronic Active, Diffuse| 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + +|
Basophilic Focus, Multiple | X X X X |
Cytoplasmic Alteration, Focal | |
Degeneration, Cystic, Focal | |
Necrosis, Acute | |
Bile Duct, Hyperplasia, Multifocal | 3 2 3 2 3 2 2 |
Centrilobular, Vacuolization | |
Cytoplasmic, Diffuse | |
Periportal, Vacuolization | |
Cytoplasmic, Diffuse | |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic Active | 4 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + +|
Acinus, Atrophy | 4 |
Acinus, Hyperplasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + +|
Degeneration, Chronic, Multifocal | 3 3 3 2 3 2 2 3 3 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + +|
Cytoplasmic Alteration | |
Degeneration, Fatty | 2 2 |
Hyperplasia | 2 |
Hypertrophy | |
_____________________________________________________________________________________________________________________|
Page 99
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 2| 6| 7| 6| 7| 2| 7| 7| 7| 7| 5|
DAY ON TEST | 6| 3| 3| 0| 3| 3| 4| 7| 3| 3| 3| 6| 3| 4| 9| 9| 1| 7| 3| 9| 3| 3| 3| 1| 8|
| 1| 1| 1| 9| 1| 1| 4| 2| 1| 2| 2| 9| 2| 0| 7| 1| 6| 4| 2| 0| 2| 2| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
70 UG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Bilateral, Atrophy, Diffuse | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + M + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + I + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + +|
Atrophy, Diffuse | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active, | |
Multifocal | 3 3 2 2 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + +|
Atrophy, Diffuse | |
Epithelium, Hyperplasia, Multifocal | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 3 3 4 4 4 3 4 4 4 4 4 3 3 4 4 4 4 4 |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + A + + + + + + + +|
Red Pulp, Fibrosis | 3 |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + M + + + + + + + +|
Hyperplasia, Cystic, Multifocal | 2 2 3 3 4 3 3 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + I + + + + + + + +|
Hyperkeratosis | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 100
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 2| 6| 7| 6| 7| 2| 7| 7| 7| 7| 5|
DAY ON TEST | 6| 3| 3| 0| 3| 3| 4| 7| 3| 3| 3| 6| 3| 4| 9| 9| 1| 7| 3| 9| 3| 3| 3| 1| 8|
| 1| 1| 1| 9| 1| 1| 4| 2| 1| 2| 2| 9| 2| 0| 7| 1| 6| 4| 2| 0| 2| 2| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
70 UG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + +|
Compression | |
Ventricle, Hydrocephalus | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + +|
Congestion | 2 |
Foreign Body, Multifocal | 3 2 |
Alveolar Epithelium, Hyperplasia | 3 3|
Interstitium, Inflammation, Acute, | |
Multifocal | 2 |
Interstitium, Inflammation, Chronic | |
Active, Multifocal | 2 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + +|
Nasolacrimal Duct, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 2 |
Retina, Atrophy, Diffuse | 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + M + M + + + M +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 |
Nephropathy, Chronic, Diffuse | 2 3 2 4 2 3 2 2 4 2 3 2 3 2 1 2 2 3 4 1 4 3 3 2 1|
Renal Tubule, Epithelium, | |
Cytoplasmic Alteration, Focal | |
Renal Tubule, Epithelium, | |
Cytoplasmic Alteration, | |
Multifocal | |
Renal Tubule, Epithelium, | |
Degeneration, Multifocal | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2|
Renal Tubule, Epithelium, | |
Hyperplasia, Focal | 2 2 2 2 2 |
Renal Tubule, Epithelium, | |
Hyperplasia, Multifocal | 2 2 2 2 |
Renal Tubule, Epithelium, | |
Karyomegaly, Multifocal | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 1 2|
_____________________________________________________________________________________________________________________|
Page 101
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 2| 6| 7| 6| 7| 2| 7| 7| 7| 7| 5|
DAY ON TEST | 6| 3| 3| 0| 3| 3| 4| 7| 3| 3| 3| 6| 3| 4| 9| 9| 1| 7| 3| 9| 3| 3| 3| 1| 8|
| 1| 1| 1| 9| 1| 1| 4| 2| 1| 2| 2| 9| 2| 0| 7| 1| 6| 4| 2| 0| 2| 2| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
70 UG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Epithelium, | |
Proliferation, Focal | 2 2 |
Renal Tubule, Epithelium, | |
Proliferation, Multifocal | 3 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 102
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
70 UG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + |
__________________________________________________________________________|
Intestine Large | + |
__________________________________________________________________________|
Intestine Large, Cecum | A |
Inflammation, Chronic Active, Diffuse| |
__________________________________________________________________________|
Intestine Large, Colon | + |
__________________________________________________________________________|
Intestine Large, Rectum | + |
__________________________________________________________________________|
Intestine Small | + |
__________________________________________________________________________|
Intestine Small, Duodenum | A |
__________________________________________________________________________|
Intestine Small, Ileum | A |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
__________________________________________________________________________|
Liver | + |
Basophilic Focus, Multiple | |
Cytoplasmic Alteration, Focal | |
Degeneration, Cystic, Focal | |
Necrosis, Acute | |
Bile Duct, Hyperplasia, Multifocal | |
Centrilobular, Vacuolization | |
Cytoplasmic, Diffuse | 2 |
Periportal, Vacuolization | |
Cytoplasmic, Diffuse | |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + |
Acinus, Atrophy | |
Acinus, Hyperplasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + |
__________________________________________________________________________|
Stomach | + |
__________________________________________________________________________|
Stomach, Forestomach | + |
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + |
Degeneration, Chronic, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + |
Cytoplasmic Alteration | |
Degeneration, Fatty | |
Hyperplasia | |
Hypertrophy | |
_____________________________________________________________________________________________________________________|
Page 103
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
70 UG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Bilateral, Atrophy, Diffuse | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + |
__________________________________________________________________________|
Parathyroid Gland | + |
__________________________________________________________________________|
Pituitary Gland | + |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + |
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + |
Atrophy, Diffuse | |
__________________________________________________________________________|
Preputial Gland | + |
Hyperplasia | |
Inflammation, Chronic Active, | |
Multifocal | |
__________________________________________________________________________|
Prostate | + |
Atrophy, Diffuse | |
Epithelium, Hyperplasia, Multifocal | |
__________________________________________________________________________|
Testes | + |
Germinal Epithelium, Atrophy | 3 |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + |
__________________________________________________________________________|
Spleen | + |
Red Pulp, Fibrosis | |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | |
__________________________________________________________________________|
Thymus | + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + |
Hyperplasia, Cystic, Multifocal | |
__________________________________________________________________________|
Skin | + |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
70 UG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + |
Compression | |
Ventricle, Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + |
Congestion | |
Foreign Body, Multifocal | 2 |
Alveolar Epithelium, Hyperplasia | |
Interstitium, Inflammation, Acute, | |
Multifocal | |
Interstitium, Inflammation, Chronic | |
Active, Multifocal | |
__________________________________________________________________________|
Nose | + |
Nasolacrimal Duct, Hyperplasia | 3 |
__________________________________________________________________________|
Trachea | + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Atrophy, Diffuse | |
__________________________________________________________________________|
Harderian Gland | M |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + |
Fibrosis, Focal | |
Nephropathy, Chronic, Diffuse | 1 |
Renal Tubule, Epithelium, | |
Cytoplasmic Alteration, Focal | |
Renal Tubule, Epithelium, | |
Cytoplasmic Alteration, | |
Multifocal | |
Renal Tubule, Epithelium, | |
Degeneration, Multifocal | 2 |
Renal Tubule, Epithelium, | |
Hyperplasia, Focal | |
Renal Tubule, Epithelium, | |
Hyperplasia, Multifocal | |
Renal Tubule, Epithelium, | |
Karyomegaly, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
Page 105
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
70 UG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Epithelium, | |
Proliferation, Focal | |
Renal Tubule, Epithelium, | |
Proliferation, Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + |
_____________________________________________________________________________________________________________________|
Page 106
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| | A |
70 UG/KG | 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 25 |
__________________________________________________________________________|____________|
Intestine Large | | 25 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 20 |
Inflammation, Chronic Active, Diffuse| | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | | 24 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 24 |
__________________________________________________________________________|____________|
Intestine Small | | 25 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 23 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 21 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 22 |
__________________________________________________________________________|____________|
Liver | | 26 |
Basophilic Focus, Multiple | | 8 |
Cytoplasmic Alteration, Focal | | 1 3.0|
Degeneration, Cystic, Focal | | 1 2.0|
Necrosis, Acute | | 1 2.0|
Bile Duct, Hyperplasia, Multifocal | | 14 2.5|
Centrilobular, Vacuolization | | |
Cytoplasmic, Diffuse | | 2 2.0|
Periportal, Vacuolization | | |
Cytoplasmic, Diffuse | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 5 |
Inflammation, Chronic Active | | 4 3.8|
__________________________________________________________________________|____________|
Pancreas | | 24 |
Acinus, Atrophy | | 1 4.0|
Acinus, Hyperplasia, Focal | | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | | 25 |
__________________________________________________________________________|____________|
Stomach | | 25 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 25 |
Inflammation, Chronic Active | | 2 2.0|
Ulcer | | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | | 25 |
__________________________________________________________________________|____________|
Tongue | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 25 |
Degeneration, Chronic, Multifocal | | 22 2.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 28 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 107
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| | A |
70 UG/KG | 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 25 |
Cytoplasmic Alteration | | 1 2.0|
Degeneration, Fatty | | 3 2.0|
Hyperplasia | | 2 1.5|
Hypertrophy | | 1 2.0|
Bilateral, Atrophy, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 26 |
Hyperplasia | | 4 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 26 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 21 |
__________________________________________________________________________|____________|
Pituitary Gland | | 27 |
Pars Distalis, Cyst | | 2 |
Pars Distalis, Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | | 26 |
C-Cell, Hyperplasia | | 10 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 25 |
Atrophy, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | | 25 |
Hyperplasia | | 1 3.0|
Inflammation, Chronic Active, | | |
Multifocal | | 11 2.4|
__________________________________________________________________________|____________|
Prostate | | 25 |
Atrophy, Diffuse | | 1 3.0|
Epithelium, Hyperplasia, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Testes | | 48 |
Germinal Epithelium, Atrophy | | 40 3.6|
Interstitial Cell, Hyperplasia | | 14 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 25 |
__________________________________________________________________________|____________|
Lymph Node | | 25 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 23 |
__________________________________________________________________________|____________|
Spleen | | 27 |
Red Pulp, Fibrosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 108
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| | A |
70 UG/KG | 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | | 20 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 23 |
Hyperplasia, Cystic, Multifocal | | 18 2.5|
__________________________________________________________________________|____________|
Skin | | 30 |
Hyperkeratosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 25 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 25 |
Compression | | 1 |
Ventricle, Hydrocephalus | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 27 |
Congestion | | 2 2.5|
Foreign Body, Multifocal | | 5 2.4|
Alveolar Epithelium, Hyperplasia | | 2 3.0|
Interstitium, Inflammation, Acute, | | |
Multifocal | | 1 2.0|
Interstitium, Inflammation, Chronic | | |
Active, Multifocal | | 2 2.5|
__________________________________________________________________________|____________|
Nose | | 24 |
Nasolacrimal Duct, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | | 25 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 4 |
Lens, Cataract | | 2 2.5|
Retina, Atrophy, Diffuse | | 2 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 19 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 109
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| | A |
70 UG/KG | 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Fibrosis, Focal | | 1 2.0|
Nephropathy, Chronic, Diffuse | | 51 2.6|
Renal Tubule, Epithelium, | | |
Cytoplasmic Alteration, Focal | | 2 2.5|
Renal Tubule, Epithelium, | | |
Cytoplasmic Alteration, | | |
Multifocal | | 1 2.0|
Renal Tubule, Epithelium, | | |
Degeneration, Multifocal | | 50 1.9|
Renal Tubule, Epithelium, | | |
Hyperplasia, Focal | | 11 2.1|
Renal Tubule, Epithelium, | | |
Hyperplasia, Multifocal | | 5 2.0|
Renal Tubule, Epithelium, | | |
Karyomegaly, Multifocal | | 51 1.9|
Renal Tubule, Epithelium, | | |
Proliferation, Focal | | 4 2.0|
Renal Tubule, Epithelium, | | |
Proliferation, Multifocal | | 6 2.2|
__________________________________________________________________________|____________|
Urinary Bladder | | 24 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 110
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 5| 4| 7| 6| 6| 7| 7| 6| 4| 5| 6| 6| 5| 7| 7| 5| 7| 7| 7| 3| 4|
DAY ON TEST | 2| 2| 1| 2| 1| 1| 2| 3| 4| 2| 2| 9| 0| 4| 4| 8| 8| 2| 3| 4| 3| 3| 3| 9| 3|
| 9| 9| 3| 5| 3| 5| 9| 8| 7| 9| 9| 0| 0| 0| 9| 4| 9| 9| 0| 0| 0| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
210 UG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + M + + + M + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Acute, Focal | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Multifocal | |
Basophilic Focus, Multiple | X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X |
Clear Cell Focus, Multiple | |
Cytoplasmic Alteration, Focal | 2 2 |
Degeneration, Cystic, Focal | |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation, | |
Multifocal | |
Inflammation, Chronic Active, | |
Multifocal | 2 |
Necrosis, Acute | |
Thrombosis | |
Bile Duct, Hyperplasia, Multifocal | 2 2 2 2 4 2 2 3 3 3 3 2 3 2 3|
Centrilobular, Vacuolization | |
Cytoplasmic, Diffuse | 2 3 2 2 2 2 2 3 2 2 3 |
Periportal, Vacuolization | |
Cytoplasmic, Diffuse | 4 |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Multifocal | |
Inflammation, Chronic, Diffuse | 3 |
Acinus, Atrophy | 2 3 2 4 2 2 3 |
Acinus, Focal Cellular Change | X X|
Acinus, Hyperplasia, Focal | 2 2 |
Perivascular, Inflammation, Chronic | |
Active, Multifocal | 4 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Multifocal | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 111
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 5| 4| 7| 6| 6| 7| 7| 6| 4| 5| 6| 6| 5| 7| 7| 5| 7| 7| 7| 3| 4|
DAY ON TEST | 2| 2| 1| 2| 1| 1| 2| 3| 4| 2| 2| 9| 0| 4| 4| 8| 8| 2| 3| 4| 3| 3| 3| 9| 3|
| 9| 9| 3| 5| 3| 5| 9| 8| 7| 9| 9| 0| 0| 0| 9| 4| 9| 9| 0| 0| 0| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
210 UG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | |
Acanthosis | 3 2 3 4 |
Acanthosis, Multifocal | 2 |
Cyst Epithelial Inclusion | X |
Erosion | 1 |
Inflammation, Chronic Active | 3 3 3 2 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Multifocal | 2 |
Ulcer | 2 |
__________________________________________________________________________|
Tongue | |
Epithelium, Hyperkeratosis, Focal | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic, Multifocal | 3 3 2 2 3 3 3 3 3 3 2 2 3 2 2 2 3 3 2 3 2 2 2|
Epicardium, Fibrosis, Multifocal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | |
Degeneration, Fatty | 2 2 2 2 2 2 |
Degeneration | 2 3 |
Hyperplasia | 3 2 2 2 2 2|
Hyperplasia, Multifocal | |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Hyperplasia | 2 2 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 3 2 2 3 2 |
Pars Intermedia, Cyst | X |
Pars Nervosa, Hyperplasia | |
Rathke's Cleft, Cyst, Multiple | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 3 2 2|
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
Page 112
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 5| 4| 7| 6| 6| 7| 7| 6| 4| 5| 6| 6| 5| 7| 7| 5| 7| 7| 7| 3| 4|
DAY ON TEST | 2| 2| 1| 2| 1| 1| 2| 3| 4| 2| 2| 9| 0| 4| 4| 8| 8| 2| 3| 4| 3| 3| 3| 9| 3|
| 9| 9| 3| 5| 3| 5| 9| 8| 7| 9| 9| 0| 0| 0| 9| 4| 9| 9| 0| 0| 0| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
210 UG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Inflammation, Chronic Active, Diffuse| |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, | |
Multifocal | 2 3 2 3 3 2 4 3 2 3 2 3 3 2 2 3 3 3 3 3|
Duct, Ectasia | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Dilatation, Diffuse | 3 |
Inflammation, Chronic Active, | |
Multifocal | 3 3 2 3 2 |
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, | |
Diffuse, Necrotizing | |
Germinal Epithelium, Atrophy | 4 4 4 4 3 4 4 4 4 4 4 4 4 3 4 4 |
Interstitial Cell, Hyperplasia | 3 2 3 2 2 2 2 2 2 2 2 2 2|
Perivascular, Inflammation, Chronic, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + |
Neutrophilia | X X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Diffuse, | |
Neutrophil | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage, Multifocal | |
Mesenteric, Cyst | |
Mesenteric, Inflammation, Chronic | |
Active, Multifocal | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Multifocal | |
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Red Pulp, Fibrosis | 3 |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 3 3 3|
Red Pulp, Infiltration Cellular, | |
_____________________________________________________________________________________________________________________|
Page 113
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 5| 4| 7| 6| 6| 7| 7| 6| 4| 5| 6| 6| 5| 7| 7| 5| 7| 7| 7| 3| 4|
DAY ON TEST | 2| 2| 1| 2| 1| 1| 2| 3| 4| 2| 2| 9| 0| 4| 4| 8| 8| 2| 3| 4| 3| 3| 3| 9| 3|
| 9| 9| 3| 5| 3| 5| 9| 8| 7| 9| 9| 0| 0| 0| 9| 4| 9| 9| 0| 0| 0| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
210 UG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Multifocal, Lipocyte | 3 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + M + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + + + + M + + + M + + M|
Hyperplasia, Cystic, Multifocal | 2 3 3 3 3 2 3 4 3 2 3 2 2 3 2 2 3 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body, Multifocal | 1 3 2 |
Alveolar Epithelium, Hyperplasia | |
Interstitium, Inflammation, Chronic | |
Active, Multifocal | 3 3 3 3 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Foreign Body | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Atrophy, Diffuse | |
__________________________________________________________________________|
Harderian Gland | + + + M + + + + + + + + M M + + + + + + + + + M M|
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Cyst, Multiple | X X |
Hydronephrosis | |
Nephropathy, Chronic, Diffuse | 3 4 4 2 2 4 2 2 4 3 3 1 2 2 3 4 3 3 2 4 3 4 2|
Pelvis, Epithelium, Hyperplasia, | |
Multifocal | |
Pelvis, Epithelium, Hyperplasia, | |
Multifocal, Papillary | |
Renal Tubule, Epithelium, | |
Cytoplasmic Alteration, Focal | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 114
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 5| 4| 7| 6| 6| 7| 7| 6| 4| 5| 6| 6| 5| 7| 7| 5| 7| 7| 7| 3| 4|
DAY ON TEST | 2| 2| 1| 2| 1| 1| 2| 3| 4| 2| 2| 9| 0| 4| 4| 8| 8| 2| 3| 4| 3| 3| 3| 9| 3|
| 9| 9| 3| 5| 3| 5| 9| 8| 7| 9| 9| 0| 0| 0| 9| 4| 9| 9| 0| 0| 0| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
210 UG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Epithelium, | |
Cytoplasmic Alteration, | |
Multifocal | 2 |
Renal Tubule, Epithelium, | |
Degeneration, Multifocal | 2 2 2 2 2 2 2 2 2 3 3 3 2 3 2 2 3 2 2 2 3 2 2 2 2|
Renal Tubule, Epithelium, | |
Hyperplasia, Focal | 2 2 2 3 2 2|
Renal Tubule, Epithelium, | |
Hyperplasia, Multifocal | 2 2 |
Renal Tubule, Epithelium, | |
Karyomegaly, Multifocal | 2 2 2 3 2 2 2 2 2 2 2 3 3 3 2 2 2 2 2 3 2 2 2 2 3|
Renal Tubule, Epithelium, | |
Proliferation, Focal | 2 2 2 |
Renal Tubule, Epithelium, | |
Proliferation, Multifocal | 2 2 2 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Mucosa, Hyperplasia, Diffuse | |
Serosa, Necrosis, Chronic Active, | |
Multifocal | 3 |
Submucosa, Inflammation, Chronic | |
Active, Multifocal | |
_____________________________________________________________________________________________________________________|
Page 115
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 4| 7| 6| 5| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 4| 3| 3| 3| 4| 0| 2| 4| 0| 4| 6| 6| 0| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 4| 3|
| 4| 0| 0| 1| 0| 8| 3| 7| 6| 7| 1| 9| 2| 1| 1| 1| 1| 1| 2| 2| 7| 2| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
210 UG/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Acute, Focal | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Multifocal | 2 |
Basophilic Focus, Multiple | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Clear Cell Focus, Multiple | X |
Cytoplasmic Alteration, Focal | |
Degeneration, Cystic, Focal | 2 |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 |
Inflammation, Chronic Active, | |
Multifocal | 2 2 |
Necrosis, Acute | 2 |
Thrombosis | X |
Bile Duct, Hyperplasia, Multifocal | 3 3 2 2 3 3 2 3 4 3 3 3 3 2 3|
Centrilobular, Vacuolization | |
Cytoplasmic, Diffuse | 3 2 |
Periportal, Vacuolization | |
Cytoplasmic, Diffuse | |
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Chronic Active | 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Multifocal | 2 |
Inflammation, Chronic, Diffuse | |
Acinus, Atrophy | 2 2 3 2 2 2 2 |
Acinus, Focal Cellular Change | X X X |
Acinus, Hyperplasia, Focal | 2 2 3 2 3 2|
Perivascular, Inflammation, Chronic | |
Active, Multifocal | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Multifocal | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 116
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 4| 7| 6| 5| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 4| 3| 3| 3| 4| 0| 2| 4| 0| 4| 6| 6| 0| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 4| 3|
| 4| 0| 0| 1| 0| 8| 3| 7| 6| 7| 1| 9| 2| 1| 1| 1| 1| 1| 2| 2| 7| 2| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
210 UG/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | 1 |
Acanthosis | 2 4 2 2 |
Acanthosis, Multifocal | |
Cyst Epithelial Inclusion | |
Erosion | |
Inflammation, Chronic Active | 3 2 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A + + + + + + + + + + + + + + + +|
Hyperplasia, Multifocal | |
Ulcer | 2 2 3 |
__________________________________________________________________________|
Tongue | + + |
Epithelium, Hyperkeratosis, Focal | 3 |
Epithelium, Hyperplasia | 3 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic, Multifocal | 3 3 2 2 2 2 4 2 3 3 2 3 3 3 3 3 3 2 3 2 2 3 2 2|
Epicardium, Fibrosis, Multifocal | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | 2 |
Degeneration, Fatty | 2 2 2 3 2 2 |
Degeneration | |
Hyperplasia | 2 2 2 2 2 3 2|
Hyperplasia, Multifocal | 2 |
Hypertrophy | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Hyperplasia | 2 2 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 2 3|
Pars Intermedia, Cyst | |
Pars Nervosa, Hyperplasia | 2 |
Rathke's Cleft, Cyst, Multiple | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 117
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 4| 7| 6| 5| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 4| 3| 3| 3| 4| 0| 2| 4| 0| 4| 6| 6| 0| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 4| 3|
| 4| 0| 0| 1| 0| 8| 3| 7| 6| 7| 1| 9| 2| 1| 1| 1| 1| 1| 2| 2| 7| 2| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
210 UG/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Inflammation, Chronic Active, Diffuse| 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, | |
Multifocal | 2 3 2 3 2 3 3 2 2 2 2 2 2 2 2 2 2 2|
Duct, Ectasia | 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Dilatation, Diffuse | |
Inflammation, Chronic Active, | |
Multifocal | 2 2 2 2 4 3 2|
__________________________________________________________________________|
Seminal Vesicle | + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, | |
Diffuse, Necrotizing | 4 |
Germinal Epithelium, Atrophy | 3 3 4 4 4 3 3 4 3 4 4 4 4 3 4 4 3|
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2|
Perivascular, Inflammation, Chronic, | |
Multifocal | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + |
Neutrophilia | X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Diffuse, | |
Neutrophil | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage, Multifocal | 3 |
Mesenteric, Cyst | X |
Mesenteric, Inflammation, Chronic | |
Active, Multifocal | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Multifocal | 2 2 |
Infiltration Cellular, Plasma Cell | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Red Pulp, Fibrosis | 3 |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 3 4 3 3 3 |
Red Pulp, Infiltration Cellular, | |
_____________________________________________________________________________________________________________________|
Page 118
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 4| 7| 6| 5| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 4| 3| 3| 3| 4| 0| 2| 4| 0| 4| 6| 6| 0| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 4| 3|
| 4| 0| 0| 1| 0| 8| 3| 7| 6| 7| 1| 9| 2| 1| 1| 1| 1| 1| 2| 2| 7| 2| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
210 UG/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Multifocal, Lipocyte | |
__________________________________________________________________________|
Thymus | + + + + + M M + + + + + M M + + + M M M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + M + + + + + + M M M + + + + + M +|
Hyperplasia, Cystic, Multifocal | 3 2 2 3 3 2 2 2 2 2 2 3 2 3 3 2 2 3 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body, Multifocal | 2 3 2 |
Alveolar Epithelium, Hyperplasia | 3 |
Interstitium, Inflammation, Chronic | |
Active, Multifocal | 3 1 4 2 2 2 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Foreign Body | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 4 3 |
Retina, Atrophy, Diffuse | 4 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + M + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
Cyst, Multiple | X X |
Hydronephrosis | 4 |
Nephropathy, Chronic, Diffuse | 2 3 3 3 2 2 4 3 2 3 3 3 3 4 3 3 2 4 4 3 3 3 3 2 3|
Pelvis, Epithelium, Hyperplasia, | |
Multifocal | 3 |
Pelvis, Epithelium, Hyperplasia, | |
Multifocal, Papillary | 2 |
Renal Tubule, Epithelium, | |
Cytoplasmic Alteration, Focal | 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 119
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 4| 7| 6| 5| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 4| 3| 3| 3| 4| 0| 2| 4| 0| 4| 6| 6| 0| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 4| 3|
| 4| 0| 0| 1| 0| 8| 3| 7| 6| 7| 1| 9| 2| 1| 1| 1| 1| 1| 2| 2| 7| 2| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
210 UG/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Epithelium, | |
Cytoplasmic Alteration, | |
Multifocal | |
Renal Tubule, Epithelium, | |
Degeneration, Multifocal | 2 2 3 2 2 2 2 3 2 2 3 2 2 3 2 2 3 2 2 3 2 2 2 2|
Renal Tubule, Epithelium, | |
Hyperplasia, Focal | 2 2 2 2 2 2 2 2 2 |
Renal Tubule, Epithelium, | |
Hyperplasia, Multifocal | 2 2 2 2 2 2 2 |
Renal Tubule, Epithelium, | |
Karyomegaly, Multifocal | 2 2 2 2 2 2 1 3 2 2 3 3 2 2 2 2 2 2 2 3 2 2 3 2 2|
Renal Tubule, Epithelium, | |
Proliferation, Focal | 2 2 2 2 2 2 2 2 2 2|
Renal Tubule, Epithelium, | |
Proliferation, Multifocal | 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Mucosa, Hyperplasia, Diffuse | 3 |
Serosa, Necrosis, Chronic Active, | |
Multifocal | |
Submucosa, Inflammation, Chronic | |
Active, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
Page 120
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
210 UG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | |
__________________________________________________________________________|
Intestine Large | |
__________________________________________________________________________|
Intestine Large, Cecum | |
__________________________________________________________________________|
Intestine Large, Colon | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | |
__________________________________________________________________________|
Intestine Small, Duodenum | |
Necrosis, Acute, Focal | |
__________________________________________________________________________|
Intestine Small, Ileum | |
__________________________________________________________________________|
Intestine Small, Jejunum | |
__________________________________________________________________________|
Liver | |
Angiectasis, Multifocal | |
Basophilic Focus, Multiple | |
Clear Cell Focus | |
Clear Cell Focus, Multiple | |
Cytoplasmic Alteration, Focal | |
Degeneration, Cystic, Focal | |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation, | |
Multifocal | |
Inflammation, Chronic Active, | |
Multifocal | |
Necrosis, Acute | |
Thrombosis | |
Bile Duct, Hyperplasia, Multifocal | |
Centrilobular, Vacuolization | |
Cytoplasmic, Diffuse | |
Periportal, Vacuolization | |
Cytoplasmic, Diffuse | |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | |
Inflammation, Acute, Multifocal | |
Inflammation, Chronic, Diffuse | |
Acinus, Atrophy | |
Acinus, Focal Cellular Change | |
Acinus, Hyperplasia, Focal | |
Perivascular, Inflammation, Chronic | |
Active, Multifocal | |
__________________________________________________________________________|
Salivary Glands | |
Acinus, Atrophy, Multifocal | |
__________________________________________________________________________|
Stomach | |
_____________________________________________________________________________________________________________________|
Page 121
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
210 UG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | |
Acanthosis, Focal | |
Acanthosis | |
Acanthosis, Multifocal | |
Cyst Epithelial Inclusion | |
Erosion | |
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | |
Hyperplasia, Multifocal | |
Ulcer | |
__________________________________________________________________________|
Tongue | |
Epithelium, Hyperkeratosis, Focal | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | |
Degeneration, Chronic, Multifocal | |
Epicardium, Fibrosis, Multifocal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | |
__________________________________________________________________________|
Adrenal Gland, Cortex | |
Cytoplasmic Alteration | |
Degeneration, Fatty | |
Degeneration | |
Hyperplasia | |
Hyperplasia, Multifocal | |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | |
Hyperplasia, Focal | |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | |
__________________________________________________________________________|
Parathyroid Gland | |
__________________________________________________________________________|
Pituitary Gland | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
Pars Intermedia, Cyst | |
Pars Nervosa, Hyperplasia | |
Rathke's Cleft, Cyst, Multiple | |
__________________________________________________________________________|
Thyroid Gland | |
C-Cell, Hyperplasia | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 122
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
210 UG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Inflammation, Chronic Active, Diffuse| |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | |
__________________________________________________________________________|
Preputial Gland | |
Inflammation, Chronic Active, | |
Multifocal | |
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | |
Cyst | |
Dilatation, Diffuse | |
Inflammation, Chronic Active, | |
Multifocal | |
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | |
Inflammation, Chronic Active, | |
Diffuse, Necrotizing | |
Germinal Epithelium, Atrophy | |
Interstitial Cell, Hyperplasia | |
Perivascular, Inflammation, Chronic, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Neutrophilia | |
__________________________________________________________________________|
Bone Marrow | |
Femoral, Hyperplasia, Diffuse, | |
Neutrophil | |
__________________________________________________________________________|
Lymph Node | |
Mediastinal, Hemorrhage, Multifocal | |
Mesenteric, Cyst | |
Mesenteric, Inflammation, Chronic | |
Active, Multifocal | |
__________________________________________________________________________|
Lymph Node, Mandibular | |
Hemorrhage, Multifocal | |
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Spleen | |
Red Pulp, Fibrosis | |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | |
Red Pulp, Infiltration Cellular, | |
_____________________________________________________________________________________________________________________|
Page 123
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
210 UG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Multifocal, Lipocyte | |
__________________________________________________________________________|
Thymus | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | |
Hyperplasia, Cystic, Multifocal | |
__________________________________________________________________________|
Skin | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | |
Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | |
Foreign Body, Multifocal | |
Alveolar Epithelium, Hyperplasia | |
Interstitium, Inflammation, Chronic | |
Active, Multifocal | |
__________________________________________________________________________|
Nose | |
Lumen, Foreign Body | |
__________________________________________________________________________|
Trachea | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Atrophy, Diffuse | |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | |
Cyst | |
Cyst, Multiple | |
Hydronephrosis | |
Nephropathy, Chronic, Diffuse | |
Pelvis, Epithelium, Hyperplasia, | |
Multifocal | |
Pelvis, Epithelium, Hyperplasia, | |
Multifocal, Papillary | |
Renal Tubule, Epithelium, | |
Cytoplasmic Alteration, Focal | |
_____________________________________________________________________________________________________________________|
Page 124
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
210 UG/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Epithelium, | |
Cytoplasmic Alteration, | |
Multifocal | |
Renal Tubule, Epithelium, | |
Degeneration, Multifocal | |
Renal Tubule, Epithelium, | |
Hyperplasia, Focal | |
Renal Tubule, Epithelium, | |
Hyperplasia, Multifocal | |
Renal Tubule, Epithelium, | |
Karyomegaly, Multifocal | |
Renal Tubule, Epithelium, | |
Proliferation, Focal | |
Renal Tubule, Epithelium, | |
Proliferation, Multifocal | |
__________________________________________________________________________|
Urinary Bladder | |
Calculus Micro Observation Only | |
Mucosa, Hyperplasia, Diffuse | |
Serosa, Necrosis, Chronic Active, | |
Multifocal | |
Submucosa, Inflammation, Chronic | |
Active, Multifocal | |
_____________________________________________________________________________________________________________________|
Page 125
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| | A |
210 UG/ | 4| 4| 4| 4| 4| | L |
KG | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 47 |
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Small | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 50 |
Necrosis, Acute, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 50 |
__________________________________________________________________________|____________|
Liver | | 50 |
Angiectasis, Multifocal | | 1 2.0|
Basophilic Focus, Multiple | | 33 |
Clear Cell Focus | | 6 |
Clear Cell Focus, Multiple | | 1 |
Cytoplasmic Alteration, Focal | | 2 2.0|
Degeneration, Cystic, Focal | | 1 2.0|
Eosinophilic Focus | | 2 |
Hematopoietic Cell Proliferation, | | |
Multifocal | | 1 2.0|
Inflammation, Chronic Active, | | |
Multifocal | | 3 2.0|
Necrosis, Acute | | 1 2.0|
Thrombosis | | 1 |
Bile Duct, Hyperplasia, Multifocal | | 30 2.7|
Centrilobular, Vacuolization | | |
Cytoplasmic, Diffuse | | 13 2.3|
Periportal, Vacuolization | | |
Cytoplasmic, Diffuse | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | | 11 |
Inflammation, Chronic Active | | 3 3.3|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Inflammation, Acute, Multifocal | | 1 2.0|
Inflammation, Chronic, Diffuse | | 1 3.0|
Acinus, Atrophy | | 14 2.4|
Acinus, Focal Cellular Change | | 5 |
Acinus, Hyperplasia, Focal | | 8 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 126
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| | A |
210 UG/ | 4| 4| 4| 4| 4| | L |
KG | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Perivascular, Inflammation, Chronic | | |
Active, Multifocal | | 3 3.3|
__________________________________________________________________________|____________|
Salivary Glands | | 49 |
Acinus, Atrophy, Multifocal | | 2 2.5|
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Acanthosis, Focal | | 1 1.0|
Acanthosis | | 8 2.8|
Acanthosis, Multifocal | | 1 2.0|
Cyst Epithelial Inclusion | | 1 |
Erosion | | 1 1.0|
Inflammation, Chronic Active | | 6 2.7|
Ulcer | | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 49 |
Hyperplasia, Multifocal | | 1 2.0|
Ulcer | | 4 2.3|
__________________________________________________________________________|____________|
Tongue | | 2 |
Epithelium, Hyperkeratosis, Focal | | 1 3.0|
Epithelium, Hyperplasia | | 2 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Degeneration, Chronic, Multifocal | | 47 2.6|
Epicardium, Fibrosis, Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Cytoplasmic Alteration | | 1 2.0|
Degeneration, Fatty | | 12 2.1|
Degeneration | | 2 2.5|
Hyperplasia | | 13 2.2|
Hyperplasia, Multifocal | | 1 2.0|
Hypertrophy | | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 49 |
Hyperplasia, Focal | | 1 2.0|
Hyperplasia | | 10 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 127
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| | A |
210 UG/ | 4| 4| 4| 4| 4| | L |
KG | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | | 49 |
Pars Distalis, Cyst | | 3 |
Pars Distalis, Hyperplasia | | 14 2.2|
Pars Intermedia, Cyst | | 1 |
Pars Nervosa, Hyperplasia | | 1 2.0|
Rathke's Cleft, Cyst, Multiple | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
C-Cell, Hyperplasia | | 16 2.1|
Follicle, Cyst | | 2 |
Follicular Cell, Hyperplasia | | 3 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
Inflammation, Chronic Active, Diffuse| | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 50 |
__________________________________________________________________________|____________|
Preputial Gland | | 48 |
Inflammation, Chronic Active, | | |
Multifocal | | 38 2.5|
Duct, Ectasia | | 3 2.0|
__________________________________________________________________________|____________|
Prostate | | 50 |
Cyst | | 1 |
Dilatation, Diffuse | | 1 3.0|
Inflammation, Chronic Active, | | |
Multifocal | | 12 2.5|
__________________________________________________________________________|____________|
Seminal Vesicle | | 1 |
__________________________________________________________________________|____________|
Testes | | 50 |
Inflammation, Chronic Active, | | |
Diffuse, Necrotizing | | 1 4.0|
Germinal Epithelium, Atrophy | | 33 3.7|
Interstitial Cell, Hyperplasia | | 24 2.1|
Perivascular, Inflammation, Chronic, | | |
Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 9 |
Neutrophilia | | 5 |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 128
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| | A |
210 UG/ | 4| 4| 4| 4| 4| | L |
KG | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Femoral, Hyperplasia, Diffuse, | | |
Neutrophil | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Mediastinal, Hemorrhage, Multifocal | | 1 3.0|
Mesenteric, Cyst | | 1 |
Mesenteric, Inflammation, Chronic | | |
Active, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
Hemorrhage, Multifocal | | 2 2.0|
Infiltration Cellular, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | | 50 |
Red Pulp, Fibrosis | | 2 3.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | | 8 3.1|
Red Pulp, Infiltration Cellular, | | |
Multifocal, Lipocyte | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | | 38 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 40 |
Hyperplasia, Cystic, Multifocal | | 38 2.5|
__________________________________________________________________________|____________|
Skin | | 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Compression | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Foreign Body, Multifocal | | 6 2.2|
Alveolar Epithelium, Hyperplasia | | 1 3.0|
Interstitium, Inflammation, Chronic | | |
Active, Multifocal | | 14 2.4|
__________________________________________________________________________|____________|
Nose | | 50 |
Lumen, Foreign Body | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 129
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| | A |
210 UG/ | 4| 4| 4| 4| 4| | L |
KG | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Lens, Cataract | | 2 3.5|
Retina, Atrophy, Diffuse | | 2 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 43 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Cyst | | 6 |
Cyst, Multiple | | 4 |
Hydronephrosis | | 1 4.0|
Nephropathy, Chronic, Diffuse | | 48 2.9|
Pelvis, Epithelium, Hyperplasia, | | |
Multifocal | | 1 3.0|
Pelvis, Epithelium, Hyperplasia, | | |
Multifocal, Papillary | | 1 2.0|
Renal Tubule, Epithelium, | | |
Cytoplasmic Alteration, Focal | | 7 2.0|
Renal Tubule, Epithelium, | | |
Cytoplasmic Alteration, | | |
Multifocal | | 1 2.0|
Renal Tubule, Epithelium, | | |
Degeneration, Multifocal | | 49 2.2|
Renal Tubule, Epithelium, | | |
Hyperplasia, Focal | | 15 2.1|
Renal Tubule, Epithelium, | | |
Hyperplasia, Multifocal | | 9 2.0|
Renal Tubule, Epithelium, | | |
Karyomegaly, Multifocal | | 50 2.2|
Renal Tubule, Epithelium, | | |
Proliferation, Focal | | 13 2.0|
Renal Tubule, Epithelium, | | |
Proliferation, Multifocal | | 13 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
Calculus Micro Observation Only | | 1 |
Mucosa, Hyperplasia, Diffuse | | 1 3.0|
Serosa, Necrosis, Chronic Active, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 130
NTP Experiment-Test: 05036-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OCHRATOXIN A Date: 05/05/97
Route: GAVAGE Time: 12:01:53
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| | |
| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| | A |
210 UG/ | 4| 4| 4| 4| 4| | L |
KG | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Multifocal | | 1 3.0|
Submucosa, Inflammation, Chronic | | |
Active, Multifocal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 131
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