TR 358 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/05/94
EXP: 05036 OCHRATOXIN A TIME: 02:39:36
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56586
CONT: N01-CP-95653 CAS: 303-47-9
PATHOLOGIST: R. PERSING S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/05/94
EXP: 05036 OCHRATOXIN A TIME: 02:39:36
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56586
CONT: N01-CP-95653 CAS: 303-47-9
PATHOLOGIST: R. PERSING S. EUSTIS
OCHRATOXIN A
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 UG/KG |
| --------------------- |
| |
| TOTAL 80 UNCENSORED DEATHS 7 CENSORED DEATHS 34 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 495 516 526 540 691 704 712 |
| CENSORED DEATHS |
| 10 10 277 277 277 277 277 277 277 277 |
| 277 277 277 277 277 277 277 377 458 458 |
| 458 458 458 458 458 458 458 458 458 458 |
| 458 458 458 486 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 21 UG/KG |
| --------------------- |
| |
| TOTAL 80 UNCENSORED DEATHS 19 CENSORED DEATHS 35 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 280 409 418 487 555 556 624 627 628 633 |
| 674 675 676 681 702 716 717 722 726 |
| CENSORED DEATHS |
| 262 277 277 277 277 277 277 277 277 277 |
| 277 277 277 277 277 277 287 417 428 458 |
| 458 458 458 458 458 458 458 458 458 458 |
| 458 458 458 488 678 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 70 UG/KG |
| --------------------- |
| |
| TOTAL 80 UNCENSORED DEATHS 23 CENSORED DEATHS 31 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 382 459 507 516 524 540 544 546 554 561 |
| 572 589 669 674 681 691 706 709 712 712 |
| 716 717 720 |
| CENSORED DEATHS |
| 277 277 277 277 277 277 277 277 277 277 |
| 277 277 277 277 277 290 297 458 458 458 |
| 458 458 458 458 458 458 458 458 458 458 |
| 458 |
| |
==================================================================================
OCHRATOXIN A
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 210 UG/ KG |
| --------------------- |
| |
| TOTAL 80 UNCENSORED DEATHS 26 CENSORED DEATHS 31 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 390 400 408 415 425 439 506 513 513 540 |
| 540 540 540 544 561 569 589 638 647 647 |
| 649 667 684 690 702 723 |
| CENSORED DEATHS |
| 277 277 277 277 277 277 277 277 277 277 |
| 277 277 277 277 277 458 458 458 458 458 |
| 458 458 458 458 458 458 458 458 458 458 |
| 647 |
| |
==================================================================================
OCHRATOXIN A
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 UG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 91.3 91.3 91.3 84.8 |
| | |
| | |
|21 UG/KG | 100.0 100.0 100.0 98.4 95.2 95.2 93.1 88.6 79.8 59.4 |
| | |
| | |
|70 UG/KG | 100.0 100.0 100.0 100.0 98.4 96.4 86.1 75.9 75.9 53.3 |
| | |
| | |
|210 UG/ KG | 100.0 100.0 100.0 100.0 92.3 90.8 74.3 68.1 59.8 49.1 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 UG/KG 21 UG/KG 70 UG/KG 210 UG/ K|
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 84.8% 59.4% 53.3% 49.1% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.001 P=0.011 P=0.002 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 597.7 605.6 608.7 556.9 |
|NATURAL DEATHS (C) | (37.4) (28.8) (20.7) (20.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 556.5 544.8 551.4 536.5 |
|(STANDARD ERROR) | (22.4) (20.3) (19.9) (18.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
OCHRATOXIN A
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 UG/KG |
| --------------------- |
| |
| TOTAL 80 UNCENSORED DEATHS 17 CENSORED DEATHS 31 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 216 466 495 497 525 568 583 598 648 654 |
| 654 660 673 675 689 695 721 |
| CENSORED DEATHS |
| 277 277 277 277 277 277 277 277 277 277 |
| 277 277 277 277 277 425 454 454 454 454 |
| 454 454 454 454 454 454 454 454 454 454 |
| 454 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 21 UG/KG |
| --------------------- |
| |
| TOTAL 80 UNCENSORED DEATHS 25 CENSORED DEATHS 32 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 201 452 452 525 538 577 585 622 624 626 |
| 632 637 638 645 646 658 658 665 665 674 |
| 704 716 716 718 726 |
| CENSORED DEATHS |
| 5 277 277 277 277 277 277 277 277 277 |
| 277 277 277 277 277 277 415 436 454 454 |
| 454 454 454 454 454 454 454 454 454 454 |
| 454 454 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 70 UG/KG |
| --------------------- |
| |
| TOTAL 80 UNCENSORED DEATHS 15 CENSORED DEATHS 30 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 319 370 466 506 506 564 589 622 637 659 |
| 665 667 669 695 697 |
| CENSORED DEATHS |
| 277 277 277 277 277 277 277 277 277 277 |
| 277 277 277 277 277 454 454 454 454 454 |
| 454 454 454 454 454 454 454 454 454 454 |
| |
==================================================================================
OCHRATOXIN A
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 210 UG/ KG |
| --------------------- |
| |
| TOTAL 80 UNCENSORED DEATHS 15 CENSORED DEATHS 30 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 305 400 415 436 520 520 560 568 626 630 |
| 645 659 699 713 721 |
| CENSORED DEATHS |
| 277 277 277 277 277 277 277 277 277 277 |
| 277 277 277 277 277 454 454 454 454 454 |
| 454 454 454 454 454 454 454 454 454 454 |
| |
==================================================================================
OCHRATOXIN A
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 728 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 728 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 UG/KG | 100.0 100.0 98.8 98.8 98.8 96.7 90.5 84.3 76.1 65.8 |
| | |
| | |
|21 UG/KG | 100.0 100.0 98.7 98.7 98.7 95.5 91.3 87.0 61.5 48.8 |
| | |
| | |
|70 UG/KG | 100.0 100.0 100.0 98.5 96.9 94.9 90.9 86.8 78.8 70.7 |
| | |
| | |
|210 UG/ KG | 100.0 100.0 100.0 98.5 95.4 93.8 89.8 85.7 77.5 71.4 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 UG/KG 21 UG/KG 70 UG/KG 210 UG/ K|
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 65.8% 48.8% 70.7% 71.4% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.269N P=0.140 P=0.788N P=0.825N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 589.2 612.0 575.4 561.1 |
|NATURAL DEATHS (C) | (30.1) (22.6) (30.6) (32.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 558.8 542.6 563.5 560.8 |
|(STANDARD ERROR) | (20.1) (20.7) (20.1) (20.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
OCHRATOXIN A
KAPLAN-MEIER SURVIVAL CURVES
0 UG/KG = 1
21 UG/KG = 2
70 UG/KG = 3
210 UG/ KG = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 34 1
| 2 34 422 3 1 31
| 424 2 31 1
| 4 4 2 3 31 1 2 1
P 90 + 4 4 3 3 1 1
E | 44 2 2 11
R | 4 3 3 1 1
C | 33 22
E 80 + 33 2 2
N | 3 3
T | 4 4 3 33
| 44 22
S 70 + 4 4 23 2
U | 4 4 3 2 2
R | 44 3322
V |
I 60 + 4 4 332 2
V | 4 4
A | 44
L | 4 4 3 3
50 + 4 4 4
|
|
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 18 obs hidden.
OCHRATOXIN A
KAPLAN-MEIER SURVIVAL CURVES
0 UG/KG = 1
21 UG/KG = 2
70 UG/KG = 3
210 UG/ KG = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1 4 3 1
| 2 4 3 3 4 4 2 1 1
| 4 4 2 3 3 2
| 1 1 2 2
P 90 + 3 1 43122 3
E | 4 1 1 31 2
R | 4 1 223 1
C | 43 11 3
E 80 + 22 4 33
N | 22 1 1 4
T | 22 131 3 4
| 1 1 444
S 70 + 22 11 3
U | 1 1
R | 2 2 11
V | 2 2
I 60 + 2 2
V | 2 2
A |
L |
50 + 22
|
|
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 26 obs hidden.
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