TR 364 Mouse Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
RHODAMINE 6G
NTP Experiment-Test: 05048-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/07/94
Route: DOSED FEED Time: 01:34:21
Facility: Southern Research Institute
Chemical CAS #: 989-38-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05048-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RHODAMINE 6G Date: 09/07/94
Route: DOSED FEED Time: 01:34:21
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.05% 0.1%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Dead 8 7 6
Moribund 3 8 7
Natural Death 1
Survivors
Terminal Sacrifice 39 35 35
Terminal Sacrifice 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small (49) (45) (48)
Duodenum, Jejunum, Autolysis 1 (2%)
Ileum, Amyloid Deposition 1 (2%)
Ileum, Peyer's Patch, Foreign Body 1 (2%)
Ileum, Peyer's Patch, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Ileum, Peyer's Patch, Inflammation,
Suppurative 1 (2%)
Jejunum, Peyer's Patch, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Wall, Inflammation, Suppurative 2 (4%)
Liver (50) (50) (49)
Angiectasis 2 (4%)
Hematopoietic Cell Proliferation 9 (18%) 4 (8%) 6 (12%)
Hemorrhage 1 (2%)
Infiltration Cellular, Lymphocyte 3 (6%) 5 (10%) 4 (8%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 2 (4%) 2 (4%) 1 (2%)
Mitotic Alteration 1 (2%)
Necrosis, Focal 2 (4%) 1 (2%)
Necrosis, Multifocal 1 (2%)
Nuclear Alteration 1 (2%)
Thrombosis 1 (2%)
Hepatocyte, Atrophy, Focal 1 (2%)
Mesentery (11) (3) (8)
Inflammation, Suppurative 4 (36%) 1 (33%) 6 (75%)
Fat, Inflammation, Chronic 1 (9%)
Fat, Necrosis, Focal 3 (27%) 2 (67%)
Pancreas (49) (48) (47)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Suppurative 1 (2%) 2 (4%)
Acinus, Atrophy, Focal 1 (2%) 1 (2%)
Acinus, Atrophy, Multifocal 1 (2%) 1 (2%)
Acinus, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05048-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RHODAMINE 6G Date: 09/07/94
Route: DOSED FEED Time: 01:34:21
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.05% 0.1%
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Duct, Cyst 2 (4%) 1 (2%)
Duct, Inflammation, Suppurative 1 (2%)
Stomach (49) (48) (47)
Forestomach, Diverticulum 1 (2%)
Forestomach, Foreign Body 1 (2%)
Forestomach, Hyperkeratosis, Focal 1 (2%)
Forestomach, Inflammation, Granulomatous 1 (2%)
Forestomach, Inflammation, Suppurative 2 (4%) 2 (4%)
Forestomach, Ulcer 1 (2%) 1 (2%)
Glandular, Hyperplasia, Focal 1 (2%)
Tooth (1)
Dysplasia 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (49)
Inflammation, Focal, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (49) (49) (49)
Capsule, Degeneration, Fatty 1 (2%)
Cortex, Degeneration, Fatty, Focal 1 (2%) 2 (4%) 2 (4%)
Cortex, Hyperplasia, Diffuse 1 (2%)
Medulla, Degeneration, Fatty 1 (2%)
Medulla, Hyperplasia, Focal 1 (2%)
Spindle Cell, Hyperplasia, Multifocal 1 (2%)
Pituitary Gland (49) (44) (46)
Pars Distalis, Angiectasis 8 (16%) 3 (7%) 6 (13%)
Pars Distalis, Cyst 2 (4%) 1 (2%)
Pars Distalis, Hyperplasia, Focal 5 (10%) 8 (18%) 5 (11%)
Thyroid Gland (50) (50) (48)
Cyst 1 (2%) 1 (2%)
Degeneration, Cystic 6 (12%) 5 (10%) 7 (15%)
Hyperplasia, Cystic 4 (8%) 1 (2%) 3 (6%)
Inflammation, Suppurative 1 (2%)
Follicular Cell, Hyperplasia, Diffuse 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia, Focal 3 (6%) 3 (6%)
Follicular Cell, Hyperplasia, Multifocal 1 (2%) 4 (8%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05048-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RHODAMINE 6G Date: 09/07/94
Route: DOSED FEED Time: 01:34:21
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.05% 0.1%
CONTROL
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (48) (45) (48)
Cyst 12 (25%) 20 (44%) 16 (33%)
Inflammation, Suppurative 9 (19%) 6 (13%) 6 (13%)
Uterus (50) (50) (49)
Angiectasis 1 (2%)
Hydrometra 1 (2%)
Hyperplasia, Cystic 47 (94%) 48 (96%) 44 (90%)
Hyperplasia, Glandular 1 (2%)
Inflammation, Suppurative 8 (16%) 9 (18%) 11 (22%)
Wall, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (48) (48) (49)
Myelofibrosis 2 (4%) 3 (6%) 2 (4%)
Myeloid Cell, Hyperplasia 6 (13%) 3 (6%) 5 (10%)
Lymph Node (50) (50) (49)
Iliac, Autolysis 1 (2%)
Iliac, Hyperplasia, Lymphoid 1 (2%)
Lumbar, Angiectasis 1 (2%)
Lumbar, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Mandibular, Hyperplasia, Lymphoid 1 (2%) 3 (6%)
Mediastinal, Hyperplasia, Lymphoid 2 (4%) 1 (2%)
Mediastinal, Inflammation, Suppurative 1 (2%) 2 (4%)
Mesenteric, Angiectasis 4 (8%) 1 (2%) 2 (4%)
Mesenteric, Hematopoietic Cell Proliferation 1 (2%) 2 (4%)
Mesenteric, Hyperplasia, Lymphoid 3 (6%) 3 (6%) 4 (8%)
Pancreatic, Hyperplasia, Lymphoid 1 (2%)
Renal, Hyperplasia, Lymphoid 1 (2%) 1 (2%) 1 (2%)
Spleen (49) (49) (49)
Atrophy 1 (2%)
Hematopoietic Cell Proliferation 10 (20%) 7 (14%) 12 (24%)
Hyperplasia, Lymphoid 4 (8%) 5 (10%) 6 (12%)
Necrosis, Focal 1 (2%)
Pigmentation 3 (6%) 1 (2%)
Thymus (48) (48) (40)
Hyperplasia, Lymphoid 1 (2%) 1 (3%)
Mediastinum, Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05048-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RHODAMINE 6G Date: 09/07/94
Route: DOSED FEED Time: 01:34:21
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.05% 0.1%
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (46) (47) (49)
Hyperplasia, Lobular 1 (2%)
Inflammation, Suppurative 1 (2%)
Duct, Ectasia 1 (2%) 3 (6%)
Skin (50) (50) (49)
Fibrosis, Focal 1 (2%)
Infiltration Cellular, Mast Cell 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (49)
Fibrous Osteodystrophy 1 (2%) 2 (4%) 2 (4%)
Skeletal Muscle (1) (1) (1)
Mineralization 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (48) (49)
Compression 1 (2%)
Corpora Amylacea 8 (16%) 6 (13%) 13 (27%)
Hemorrhage, Multifocal 1 (2%)
Meninges, Infiltration Cellular, Lymphocyte 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (49)
Hemorrhage 2 (4%) 1 (2%)
Infiltration Cellular, Lymphocyte 3 (6%) 2 (4%) 5 (10%)
Inflammation, Suppurative 2 (4%) 1 (2%)
Necrosis 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 2 (4%) 4 (8%)
Mediastinum, Inflammation, Suppurative 1 (2%) 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1) (5)
Hyperplasia 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05048-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RHODAMINE 6G Date: 09/07/94
Route: DOSED FEED Time: 01:34:21
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.05% 0.1%
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49)
Atrophy 1 (2%)
Casts Protein 1 (2%)
Cyst 1 (2%)
Glomerulosclerosis 2 (4%)
Hydronephrosis 1 (2%)
Infiltration Cellular, Lymphocyte 21 (42%) 29 (58%) 28 (57%)
Inflammation, Chronic 1 (2%)
Inflammation, Focal, Granulomatous 1 (2%)
Metaplasia, Osseous 1 (2%) 1 (2%)
Nephropathy, Chronic 3 (6%) 5 (10%) 3 (6%)
Glomerulus, Amyloid Deposition 1 (2%) 1 (2%)
Interstitial Tissue, Mineralization 2 (4%) 1 (2%)
Renal Tubule, Dilatation 1 (2%) 1 (2%)
Urinary Bladder (48) (47) (49)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%) 2 (4%)
Inflammation, Granulomatous 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05048-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RHODAMINE 6G Date: 09/07/94
Route: DOSED FEED Time: 01:34:21
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.1% 0.2%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Dead 5 9 8
Moribund 8 8 4
Moribund Sacrifice 1
Accident 1
Survivors
Terminal Sacrifice 36 32 38
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small (46) (46) (45)
Ileum, Peyer's Patch, Hyperplasia, Lymphoid 2 (4%) 1 (2%)
Liver (49) (49) (50)
Angiectasis 1 (2%) 1 (2%)
Basophilic Focus 2 (4%)
Cyst 3 (6%) 1 (2%)
Cytoplasmic Alteration, Focal 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 3 (6%) 2 (4%)
Hemorrhage, Chronic 1 (2%)
Infiltration Cellular, Lymphocyte 2 (4%)
Inflammation, Granulomatous 1 (2%)
Mineralization 1 (2%)
Necrosis 2 (4%) 4 (8%) 1 (2%)
Pigmentation, Hemosiderin 2 (4%)
Mesentery (2) (5) (5)
Hemorrhage 1 (50%)
Fat, Necrosis, Focal 3 (60%) 4 (80%)
Pancreas (48) (49) (48)
Acinus, Atrophy, Multifocal 1 (2%)
Acinus, Hyperplasia 1 (2%)
Salivary Glands (49) (49) (49)
Cyst 1 (2%)
Stomach (48) (49) (50)
Forestomach, Cyst 1 (2%) 1 (2%)
Forestomach, Edema 1 (2%)
Forestomach, Inflammation, Suppurative 1 (2%)
Forestomach, Ulcer 1 (2%)
Glandular, Mineralization 1 (2%)
Tooth (4) (3) (5)
Dysplasia 4 (100%) 3 (100%) 2 (40%)
Inflammation, Chronic 1 (33%)
Inflammation, Suppurative 1 (25%) 2 (67%) 3 (60%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05048-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RHODAMINE 6G Date: 09/07/94
Route: DOSED FEED Time: 01:34:21
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.1% 0.2%
CONTROL
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (49) (48) (49)
Cortex, Hyperplasia, Focal 1 (2%)
Medulla, Hyperplasia, Focal 1 (2%)
Medulla, Hyperplasia, Multifocal 1 (2%)
Spindle Cell, Hyperplasia, Focal 4 (8%) 1 (2%)
Spindle Cell, Hyperplasia, Multifocal 1 (2%)
Parathyroid Gland (44) (40) (41)
Cyst 1 (2%)
Thyroid Gland (50) (49) (50)
Degeneration, Cystic 13 (26%) 12 (24%) 9 (18%)
Hyperplasia, Cystic 3 (6%) 2 (4%) 5 (10%)
Infiltration Cellular, Lymphocyte 2 (4%)
C-Cell, Hyperplasia, Focal 1 (2%)
Follicle, Cyst 2 (4%) 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia, Focal 3 (6%) 4 (8%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (49) (50)
Inflammation, Diffuse, Suppurative 1 (2%)
Preputial Gland (12) (15) (25)
Fibrosis 1 (4%)
Infiltration Cellular, Lymphocyte 1 (8%) 2 (8%)
Inflammation, Chronic 1 (8%) 2 (8%)
Inflammation, Granulomatous 3 (12%)
Inflammation, Suppurative 6 (50%) 10 (67%) 8 (32%)
Metaplasia, Osseous 1 (4%)
Mineralization 1 (8%) 2 (8%)
Duct, Ectasia 7 (58%) 12 (80%) 17 (68%)
Duct, Inflammation, Suppurative 1 (8%)
Prostate (47) (48) (50)
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05048-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RHODAMINE 6G Date: 09/07/94
Route: DOSED FEED Time: 01:34:21
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.1% 0.2%
CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Seminal Vesicle (1) (2) (2)
Atrophy 1 (100%)
Inflammation, Suppurative 1 (50%)
Testes (49) (47) (50)
Atrophy 1 (2%)
Mineralization 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (49) (50)
Angiectasis 1 (2%)
Atrophy 1 (2%)
Myelofibrosis 1 (2%)
Myeloid Cell, Hyperplasia 9 (18%) 7 (14%) 5 (10%)
Lymph Node (50) (50) (50)
Inguinal, Hyperplasia, Lymphoid 2 (4%) 2 (4%) 9 (18%)
Inguinal, Hyperplasia, Plasma Cell 1 (2%)
Inguinal, Necrosis 1 (2%)
Inguinal, Pigmentation 2 (4%) 1 (2%)
Inguinal, Renal, Iliac, Autolysis 1 (2%)
Mandibular, Hyperplasia, Lymphoid 2 (4%) 2 (4%)
Mandibular, Pigmentation 1 (2%)
Mesenteric, Angiectasis 13 (26%) 8 (16%) 3 (6%)
Mesenteric, Hematopoietic Cell Proliferation 7 (14%) 1 (2%) 1 (2%)
Mesenteric, Hyperplasia, Lymphoid 8 (16%) 2 (4%) 2 (4%)
Mesenteric, Syncytial Alteration 1 (2%)
Pancreatic, Hyperplasia, Lymphoid 1 (2%)
Renal, Hyperplasia 1 (2%)
Spleen (49) (49) (48)
Atrophy 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 14 (29%) 13 (27%) 6 (13%)
Hyperplasia, Lymphoid 3 (6%) 1 (2%) 2 (4%)
Lymphoid Follicle, Amyloid Deposition 1 (2%)
Thymus (31) (40) (47)
Hyperplasia, Lymphoid 1 (3%)
Necrosis 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (48) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
Fibrosis, Focal 17 (35%) 25 (50%) 24 (48%)
Hemorrhage, Multifocal 1 (2%)
Hyperplasia, Focal 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05048-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RHODAMINE 6G Date: 09/07/94
Route: DOSED FEED Time: 01:34:21
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.1% 0.2%
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Inflammation, Chronic, Focal 2 (4%) 4 (8%)
Inflammation, Focal, Suppurative 3 (6%) 2 (4%) 1 (2%)
Mineralization 1 (2%) 1 (2%) 1 (2%)
Necrosis, Focal 1 (2%) 1 (2%)
Ulcer, Focal 5 (10%) 4 (8%) 1 (2%)
Subcutaneous Tissue, Abscess, Chronic 1 (2%) 1 (2%)
Subcutaneous Tissue, Edema 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (2)
Inflammation, Suppurative 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (49)
Corpora Amylacea 2 (4%) 12 (24%) 10 (20%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Congestion 1 (2%) 1 (2%)
Embolus Tumor 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%)
Necrosis, Diffuse 1 (2%)
Necrosis, Multifocal 1 (2%)
Alveolar Epithelium, Hyperplasia, Diffuse 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 3 (6%) 1 (2%)
Alveolar Epithelium, Hyperplasia, Multifocal 1 (2%) 1 (2%) 1 (2%)
Bronchus, Foreign Body 1 (2%)
Bronchus, Inflammation, Suppurative 1 (2%)
Nose (48) (46) (43)
Lumen, Foreign Body 1 (2%) 5 (12%)
Lumen, Inflammation, Suppurative 1 (2%) 5 (12%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%)
Submucosa, Sinus, Inflammation,
Granulomatous, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05048-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RHODAMINE 6G Date: 09/07/94
Route: DOSED FEED Time: 01:34:21
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.1% 0.2%
CONTROL
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (50)
Bacterium 2 (4%)
Degeneration, Focal 1 (2%)
Hydronephrosis 1 (2%)
Infarct 1 (2%) 1 (2%)
Infiltration Cellular, Lymphocyte 23 (46%) 23 (47%) 18 (36%)
Inflammation, Suppurative 2 (4%) 2 (4%)
Nephropathy, Chronic 38 (76%) 34 (69%) 42 (84%)
Cortex, Cyst 1 (2%)
Cortex, Fibrosis 1 (2%)
Corticomedullary Junction, Fibrosis 1 (2%)
Interstitial Tissue, Mineralization 37 (74%) 34 (69%) 40 (80%)
Interstitial Tissue, Pigmentation 1 (2%)
Medulla, Cyst 1 (2%)
Renal Tubule, Dilatation 1 (2%)
Urethra (1) (1)
Inflammation 1 (100%)
Urinary Bladder (48) (48) (48)
Inflammation, Proliferative 1 (2%)
Mucosa, Inflammation, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
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