TR 364 Mouse Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
RHODAMINE 6G
NTP Experiment-Test: 05048-02 Report: PEIRPT05
Study Type: CHRONIC Date: 09/07/94
Route: DOSED FEED Time: 01:38:26
Facility: Southern Research Institute
Chemical CAS #: 989-38-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05048-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RHODAMINE 6G Date: 09/07/94
Route: DOSED FEED Time: 01:38:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.05% 0.1%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Dead 8 7 6
Moribund 3 8 7
Natural Death 1
Survivors
Terminal Sacrifice 39 35 35
Terminal Sacrifice 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (48)
Intestine Small (49) (45) (48)
Jejunum, Polyp Adenomatous 1 (2%)
Liver (50) (50) (49)
Hemangiosarcoma 1 (2%)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Hepatocellular Carcinoma 3 (6%) 1 (2%) 4 (8%)
Hepatocellular Adenoma 5 (10%) 3 (6%) 1 (2%)
Mesentery (11) (3) (8)
Sarcoma Stromal, Focal, Metastatic 1 (13%)
Pancreas (49) (48) (47)
Salivary Glands (49) (48) (48)
Stomach (49) (48) (47)
Forestomach, Squamous Cell Papilloma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (49)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (49) (49) (49)
Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (50) (48) (48)
Adenoma 1 (2%) 2 (4%)
Carcinoma 1 (2%)
Pituitary Gland (49) (44) (46)
Pars Distalis, Adenoma 4 (8%) 4 (9%) 6 (13%)
Pars Distalis, Carcinoma 1 (2%)
Page 2
NTP Experiment-Test: 05048-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RHODAMINE 6G Date: 09/07/94
Route: DOSED FEED Time: 01:38:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.05% 0.1%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Thyroid Gland (50) (50) (48)
Bilateral, Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
Follicular Cell, Adenoma, Multiple 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (48) (45) (48)
Bilateral, Cystadenoma 1 (2%)
Uterus (50) (50) (49)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Leiomyoma 2 (4%)
Polyp Stromal, Metastatic, Glioma Malignant 1 (2%)
Sarcoma 1 (2%) 1 (2%)
Sarcoma Stromal 1 (2%) 1 (2%) 1 (2%)
Vagina (1)
Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (48) (48) (49)
Hemangioma 1 (2%)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Lymph Node (50) (50) (49)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
Spleen (49) (49) (49)
Hemangiosarcoma 1 (2%) 1 (2%)
Thymus (48) (48) (40)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (46) (47) (49)
Adenocarcinoma 2 (4%) 2 (4%)
Skin (50) (50) (49)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%)
Tail, Squamous Cell Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05048-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RHODAMINE 6G Date: 09/07/94
Route: DOSED FEED Time: 01:38:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.05% 0.1%
CONTROL
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (1) (1)
Fibrosarcoma 1 (100%)
Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (48) (49)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (49)
Alveolar/Bronchiolar Adenoma 3 (6%) 5 (10%) 3 (6%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Sarcoma 1 (2%)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1) (5)
Adenoma 4 (80%)
Carcinoma, Metastatic, Uncertain Primary Site 1 (20%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49)
Urinary Bladder (48) (47) (49)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Lymphoma Malignant Histiocytic 1 (2%) 2 (4%)
Lymphoma Malignant Lymphocytic 6 (12%) 2 (4%) 4 (8%)
Lymphoma Malignant Mixed 9 (18%) 4 (8%) 3 (6%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 05048-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RHODAMINE 6G Date: 09/07/94
Route: DOSED FEED Time: 01:38:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.05% 0.1%
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 29 33 25
Total Primary Neoplasms 41 41 33
Total Animals with Benign Neoplasms 12 20 11
Total Benign Neoplasms 16 23 15
Total Animals with Malignant Neoplasms 21 17 18
Total Malignant Neoplasms 25 18 18
Total Animals with Metastatic Neoplasms 2 2 3
Total Metastatic Neoplasm 2 4 6
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 5
NTP Experiment-Test: 05048-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RHODAMINE 6G Date: 09/07/94
Route: DOSED FEED Time: 01:38:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.1% 0.2%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Dead 5 9 8
Moribund 8 8 4
Moribund Sacrifice 1
Accident 1
Survivors
Terminal Sacrifice 36 32 38
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (31) (30) (38)
Intestine Small (46) (46) (45)
Liver (49) (49) (50)
Hepatocellular Carcinoma 9 (18%) 6 (12%) 5 (10%)
Hepatocellular Carcinoma, Multiple 1 (2%) 1 (2%)
Hepatocellular Adenoma 5 (10%) 7 (14%) 5 (10%)
Mesentery (2) (5) (5)
Pancreas (48) (49) (48)
Stomach (48) (49) (50)
Forestomach, Squamous Cell Papilloma 2 (4%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (49) (48) (49)
Pheochromocytoma Benign 1 (2%)
Cortex, Adenoma 1 (2%)
Thyroid Gland (50) (49) (50)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 3 (6%) 3 (6%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 6
NTP Experiment-Test: 05048-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RHODAMINE 6G Date: 09/07/94
Route: DOSED FEED Time: 01:38:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.1% 0.2%
CONTROL
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (12) (15) (25)
Adenoma 1 (4%)
Prostate (47) (48) (50)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (49) (50)
Lymph Node (50) (50) (50)
Fibrosarcoma, Metastatic, Skin 2 (4%) 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%)
Spleen (49) (49) (48)
Hemangiosarcoma 1 (2%)
Thymus (31) (40) (47)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (48) (50) (50)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 4 (8%) 2 (4%)
Subcutaneous Tissue, Fibrosarcoma 9 (19%) 12 (24%) 5 (10%)
Subcutaneous Tissue, Fibrosarcoma, Multiple 1 (2%) 1 (2%)
Subcutaneous Tissue, Hemangioma 1 (2%)
Subcutaneous Tissue, Sarcoma 4 (8%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (2)
Fibrosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05048-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RHODAMINE 6G Date: 09/07/94
Route: DOSED FEED Time: 01:38:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.1% 0.2%
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Alveolar/Bronchiolar Adenoma 5 (10%) 5 (10%) 4 (8%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 3 (6%) 2 (4%) 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Fibrosarcoma, Metastatic, Skin 2 (4%) 2 (4%) 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (8) (2) (3)
Adenoma 7 (88%) 2 (100%) 2 (67%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (50)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Cortex, Renal Tubule, Adenoma 1 (2%)
Urethra (1) (1)
Bulbourethral Gland, Leiomyosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Lymphoma Malignant 1 (2%)
Lymphoma Malignant Histiocytic 3 (6%) 1 (2%)
Lymphoma Malignant Lymphocytic 3 (6%) 1 (2%)
Lymphoma Malignant Mixed 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 8
NTP Experiment-Test: 05048-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RHODAMINE 6G Date: 09/07/94
Route: DOSED FEED Time: 01:38:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.1% 0.2%
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 39 33 29
Total Primary Neoplasms 58 51 37
Total Animals with Benign Neoplasms 18 17 15
Total Benign Neoplasms 23 23 19
Total Animals with Malignant Neoplasms 30 25 16
Total Malignant Neoplasms 35 28 18
Total Animals with Metastatic Neoplasms 8 4 1
Total Metastatic Neoplasm 9 5 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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