TR 364 Mouse Pathology Tables
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
Facility: Southern Research Institute
Chemical CAS #: 989-38-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 3| 3| 3| 9| 3| 3| 3| 3| 7| 5| 3| 3| 3| 8| 3| 3| 3| 3| 9| 3| 3| 3| 3|
| 0| 4| 4| 4| 4| 5| 4| 4| 5| 5| 0| 5| 5| 5| 5| 2| 5| 5| 5| 5| 1| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + M + M + + A M + + + + M + + + A + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + + + + + + + + + + + +|
Duodenum, Jejunum, Autolysis | 3 |
Ileum, Amyloid Deposition | 3 |
Ileum, Peyer's Patch, Hyperplasia, | |
Lymphoid | 4 |
Jejunum, Peyer's Patch, Hyperplasia, | |
Lymphoid | 4 |
Wall, Inflammation, Suppurative | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 3 |
Hemorrhage | 3 |
Infiltration Cellular, Lymphocyte | 2 3 2 |
Inflammation, Suppurative | 2 |
Necrosis, Focal | 4 |
Necrosis, Multifocal | 4 |
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Suppurative | 3 3 |
Fat, Inflammation, Chronic | |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + A + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Acinus, Atrophy, Focal | |
Duct, Cyst | X |
Duct, Inflammation, Suppurative | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Diverticulum | |
Forestomach, Hyperkeratosis, Focal | 3 |
Forestomach, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Capsule, Degeneration, Fatty | |
Cortex, Degeneration, Fatty, Focal | 4 |
Medulla, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 3| 3| 3| 9| 3| 3| 3| 3| 7| 5| 3| 3| 3| 8| 3| 3| 3| 3| 9| 3| 3| 3| 3|
| 0| 4| 4| 4| 4| 5| 4| 4| 5| 5| 0| 5| 5| 5| 5| 2| 5| 5| 5| 5| 1| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + M + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 3 3 3 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 3 2 3 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Degeneration, Cystic | 2 2 2 3 |
Hyperplasia, Cystic | 3 3 |
Follicular Cell, Hyperplasia, Diffuse| |
Follicular Cell, Hyperplasia, Focal | 3 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X |
Inflammation, Suppurative | 4 4 4 4 4 4 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 3 3 4 4 3 3 3 3 4 4 4 4 4 4 4 4 3 4 3 3 3|
Inflammation, Suppurative | 3 3 3 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 3 |
Myeloid Cell, Hyperplasia | 4 4 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Angiectasis | |
Mediastinal, Hyperplasia, Lymphoid | |
Mesenteric, Angiectasis | 4 |
Mesenteric, Hematopoietic Cell | |
Proliferation | |
Mesenteric, Hyperplasia, Lymphoid | 4 |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + A + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 4 3 |
Hyperplasia, Lymphoid | 3 4 3 |
Necrosis, Focal | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + M + + + M + +|
Mediastinum, Inflammation, | |
Suppurative | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 3| 3| 3| 9| 3| 3| 3| 3| 7| 5| 3| 3| 3| 8| 3| 3| 3| 3| 9| 3| 3| 3| 3|
| 0| 4| 4| 4| 4| 5| 4| 4| 5| 5| 0| 5| 5| 5| 5| 2| 5| 5| 5| 5| 1| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpora Amylacea | X X X 1|
Hemorrhage, Multifocal | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Infiltration Cellular, Lymphocyte | 2 2 |
Inflammation, Suppurative | 3 |
Necrosis | |
Mediastinum, Inflammation, | |
Suppurative | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 3 4 3 2 2 3 2 2 3 3 2 1 3 2|
Nephropathy, Chronic | 2 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + A + + + + + + + + + M + + + +|
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 2| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| |
| 4| 5| 5| 5| 5| 3| 1| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + M + + + M M + + M M + M + + + M + + + + + + + +| 37 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Duodenum, Jejunum, Autolysis | | 1 3.0|
Ileum, Amyloid Deposition | | 1 3.0|
Ileum, Peyer's Patch, Hyperplasia, | | |
Lymphoid | | 1 4.0|
Jejunum, Peyer's Patch, Hyperplasia, | | |
Lymphoid | | 1 4.0|
Wall, Inflammation, Suppurative | 4 4 | 2 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 3 3 3 3 | 9 3.0|
Hemorrhage | | 1 3.0|
Infiltration Cellular, Lymphocyte | | 3 2.3|
Inflammation, Suppurative | 3 | 2 2.5|
Necrosis, Focal | 4 | 2 4.0|
Necrosis, Multifocal | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 11 |
Inflammation, Suppurative | 4 3 | 4 3.3|
Fat, Inflammation, Chronic | 3 | 1 3.0|
Fat, Necrosis, Focal | 3 2 3 | 3 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 3 | 1 3.0|
Acinus, Atrophy, Focal | 4 | 1 4.0|
Duct, Cyst | X | 2 |
Duct, Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Forestomach, Diverticulum | X | 1 |
Forestomach, Hyperkeratosis, Focal | | 1 3.0|
Forestomach, Inflammation, | | |
Suppurative | 4 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Focal, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 2| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| |
| 4| 5| 5| 5| 5| 3| 1| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Capsule, Degeneration, Fatty | 4 | 1 4.0|
Cortex, Degeneration, Fatty, Focal | | 1 4.0|
Medulla, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + + + + + + M + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 3 3 3| 8 2.9|
Pars Distalis, Cyst | X | 2 |
Pars Distalis, Hyperplasia, Focal | 1 | 5 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Degeneration, Cystic | 3 2 | 6 2.3|
Hyperplasia, Cystic | 4 3| 4 3.3|
Follicular Cell, Hyperplasia, Diffuse| 3 | 1 3.0|
Follicular Cell, Hyperplasia, Focal | 2 | 3 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | M + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
Cyst | X X X X X | 12 |
Inflammation, Suppurative | 4 4 | 9 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 4 4 3 3 4 3 4 3 3 3 4 4 4 4 4 4 4 4 3 3 3 3 3 4 4| 47 3.5|
Inflammation, Suppurative | 4 4 3 | 8 3.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + M M + + + + + + + + + + +| 48 |
Myelofibrosis | 3 | 2 3.0|
Myeloid Cell, Hyperplasia | 4 4 4 | 6 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumbar, Angiectasis | 4 | 1 4.0|
Mediastinal, Hyperplasia, Lymphoid | 4 3 | 2 3.5|
Mesenteric, Angiectasis | 4 4 4 | 4 4.0|
Mesenteric, Hematopoietic Cell | | |
Proliferation | 4 | 1 4.0|
Mesenteric, Hyperplasia, Lymphoid | 3 4 | 3 3.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 2| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| |
| 4| 5| 5| 5| 5| 3| 1| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 4 4 2 3 4 3 | 10 3.5|
Hyperplasia, Lymphoid | 3 | 4 3.3|
Necrosis, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Mediastinum, Inflammation, | | |
Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + M + + + + + + + M + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Corpora Amylacea | X 1 X 1 | 8 1.0|
Hemorrhage, Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 2 3.0|
Infiltration Cellular, Lymphocyte | 3 | 3 2.3|
Inflammation, Suppurative | 4 | 2 3.5|
Necrosis | 4 | 1 4.0|
Mediastinum, Inflammation, | | |
Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 2| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| |
| 4| 5| 5| 5| 5| 3| 1| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 2 3 3 2 3 3 3| 21 2.6|
Nephropathy, Chronic | 3 | 3 2.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 8| 9| 3| 3| 3| 9| 3| 3| 3| 3| 5| 3| 3| 2| 2| 9| 3| 3| 3| 3| 9| 3| 3| 3| 3|
| 3| 9| 0| 0| 0| 5| 0| 0| 0| 0| 9| 8| 0| 9| 5| 4| 0| 0| 0| 0| 8| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.1% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + + + M + + + + + M + + + M + + + M M + + + +|
__________________________________________________________________________|
Intestine Large | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + + + + + +|
Jejunum, Peyer's Patch, Hyperplasia, | |
Lymphoid | |
__________________________________________________________________________|
Liver | A + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 3 |
Infiltration Cellular, Lymphocyte | 3 2 3 |
Inflammation, Granulomatous | |
Inflammation, Suppurative | 3 |
Necrosis, Focal | |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Suppurative | 4 3 3 |
__________________________________________________________________________|
Pancreas | A + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 3 |
Acinus, Atrophy, Multifocal | 4 |
__________________________________________________________________________|
Salivary Glands | A + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Stomach | A + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Foreign Body | |
Forestomach, Inflammation, | |
Granulomatous | |
Forestomach, Ulcer | 3 |
Glandular, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | A + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | A + + + + + + + + + + + + + + + + + + + + + + + +|
Cortex, Degeneration, Fatty, Focal | |
Cortex, Hyperplasia, Diffuse | 3 |
__________________________________________________________________________|
Islets, Pancreatic | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | A + + + + + + + + + M + + + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | A + + + + M + + + + + + + + + + + + + + I + + + +|
Pars Distalis, Angiectasis | 3 4 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Thyroid Gland | A + + + + + + + + + + + + + M + + + + + + + + + +|
Cyst | X |
Degeneration, Cystic | 3 3 |
Hyperplasia, Cystic | 3 3 |
Inflammation, Suppurative | |
Follicular Cell, Hyperplasia, Focal | 3 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 8| 9| 3| 3| 3| 9| 3| 3| 3| 3| 5| 3| 3| 2| 2| 9| 3| 3| 3| 3| 9| 3| 3| 3| 3|
| 3| 9| 0| 0| 0| 5| 0| 0| 0| 0| 9| 8| 0| 9| 5| 4| 0| 0| 0| 0| 8| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.1% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Hyperplasia, | |
Multifocal | 3 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | A + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X X 2 3|
Inflammation, Suppurative | 4 4 |
__________________________________________________________________________|
Uterus | A + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hydrometra | |
Hyperplasia, Cystic | 3 3 2 4 3 4 4 3 4 3 4 4 4 3 4 4 4 4 3 4 4 3 3 4|
Hyperplasia, Glandular | |
Inflammation, Suppurative | 4 4 3 3 |
__________________________________________________________________________|
Vagina | A |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | A + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 |
Myeloid Cell, Hyperplasia | 4 4 |
__________________________________________________________________________|
Lymph Node | A + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Autolysis | |
Lumbar, Hyperplasia, Lymphoid | 3 |
Mandibular, Hyperplasia, Lymphoid | 4 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Inflammation, | |
Suppurative | 3 |
Mesenteric, Angiectasis | 4 |
Mesenteric, Hyperplasia, Lymphoid | 3 3|
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | A + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 4 3 3 4 4 |
Hyperplasia, Lymphoid | 3 3 3 4|
Pigmentation | |
__________________________________________________________________________|
Thymus | A M + + + + + + + + M + + + M + M + + M + + + + +|
Hyperplasia, Lymphoid | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | A + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Ectasia | 3 3 |
__________________________________________________________________________|
Skin | A + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 8| 9| 3| 3| 3| 9| 3| 3| 3| 3| 5| 3| 3| 2| 2| 9| 3| 3| 3| 3| 9| 3| 3| 3| 3|
| 3| 9| 0| 0| 0| 5| 0| 0| 0| 0| 9| 8| 0| 9| 5| 4| 0| 0| 0| 0| 8| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.1% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Fibrosis, Focal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | A + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | A + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 |
Corpora Amylacea | X X X X X X 2 X X 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | A + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Infiltration Cellular, Lymphocyte | 3 3 |
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Mediastinum, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Nose | A + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | A + + + + + + + + + + + + + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | A + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | |
Glomerulosclerosis | 3 |
Infiltration Cellular, Lymphocyte | 2 3 2 2 3 2 2 3 3 3 3|
Inflammation, Focal, Granulomatous | 4 |
Metaplasia, Osseous | |
Nephropathy, Chronic | 3 2 |
Glomerulus, Amyloid Deposition | 4 |
Interstitial Tissue, Mineralization | 1 |
Renal Tubule, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 3 2|
Inflammation, Granulomatous | 4 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| 8| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 5| 0| 0| 0| 0| 3| 6| 0| 0| 0| 5| 2| 8| 0| 0| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.1% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + M + M + M + + + M A M + + + + M + M + M + + + +| 35 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
Jejunum, Peyer's Patch, Hyperplasia, | | |
Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 3 2 3 | 6 2.7|
Infiltration Cellular, Lymphocyte | 2 | 4 2.5|
Inflammation, Granulomatous | 3 | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
Necrosis, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 8 |
Inflammation, Suppurative | 3 4 3 | 6 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + A A + + + + + + + + + + + + +| 47 |
Acinus, Atrophy, Focal | | 1 3.0|
Acinus, Atrophy, Multifocal | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + A A + + + + + + + + + + + + +| 47 |
Forestomach, Foreign Body | 3 | 1 3.0|
Forestomach, Inflammation, | | |
Granulomatous | 4 | 1 4.0|
Forestomach, Ulcer | | 1 3.0|
Glandular, Hyperplasia, Focal | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cortex, Degeneration, Fatty, Focal | 3 3 | 2 3.0|
Cortex, Hyperplasia, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + M + + + + M + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 46 |
Pars Distalis, Angiectasis | 3 3 3 3 | 6 3.2|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia, Focal | 3 2 2 2 | 5 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| 8| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 5| 0| 0| 0| 0| 3| 6| 0| 0| 0| 5| 2| 8| 0| 0| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.1% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Cyst | | 1 |
Degeneration, Cystic | 3 3 3 3 2 | 7 2.9|
Hyperplasia, Cystic | 4 | 3 3.3|
Inflammation, Suppurative | 3 | 1 3.0|
Follicular Cell, Hyperplasia, Focal | 2 3 | 3 2.7|
Follicular Cell, Hyperplasia, | | |
Multifocal | 3 3 | 4 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
Cyst | 3 X X X X X | 16 2.7|
Inflammation, Suppurative | 4 4 4 4 | 6 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 3.0|
Hydrometra | 4 | 1 4.0|
Hyperplasia, Cystic | 4 4 4 4 4 4 3 3 4 4 4 4 3 3 4 3 3 3 3 3| 44 3.5|
Hyperplasia, Glandular | 4 | 1 4.0|
Inflammation, Suppurative | 4 4 3 4 4 2 3 | 11 3.5|
__________________________________________________________________________|____________|
Vagina | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Myelofibrosis | 2 | 2 2.0|
Myeloid Cell, Hyperplasia | 4 4 4 | 5 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Iliac, Autolysis | 4 | 1 4.0|
Lumbar, Hyperplasia, Lymphoid | | 1 3.0|
Mandibular, Hyperplasia, Lymphoid | 4 3 | 3 3.7|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Inflammation, | | |
Suppurative | 3 | 2 3.0|
Mesenteric, Angiectasis | 3 | 2 3.5|
Mesenteric, Hyperplasia, Lymphoid | 3 4 | 4 3.3|
Pancreatic, Hyperplasia, Lymphoid | 3 | 1 3.0|
Renal, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| 8| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 5| 0| 0| 0| 0| 3| 6| 0| 0| 0| 5| 2| 8| 0| 0| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.1% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 4 3 4 3 4 4 | 12 3.6|
Hyperplasia, Lymphoid | 3 3 | 6 3.2|
Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + M + M M M + + + + + + + + + + + + + + + + +| 40 |
Hyperplasia, Lymphoid | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Duct, Ectasia | 4 | 3 3.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrous Osteodystrophy | 3 X | 2 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Compression | | 1 4.0|
Corpora Amylacea | X X X | 13 1.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 3.0|
Infiltration Cellular, Lymphocyte | 3 2 2 | 5 2.6|
Inflammation, Suppurative | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 2 2 | 4 2.0|
Mediastinum, Inflammation, | | |
Suppurative | 4 2 | 2 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| 8| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 5| 0| 0| 0| 0| 3| 6| 0| 0| 0| 5| 2| 8| 0| 0| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.1% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Casts Protein | 4 | 1 4.0|
Glomerulosclerosis | 3 | 2 3.0|
Infiltration Cellular, Lymphocyte | 3 3 3 2 3 2 3 2 2 3 3 2 2 2 3 2 3 | 28 2.5|
Inflammation, Focal, Granulomatous | | 1 4.0|
Metaplasia, Osseous | 3 | 1 3.0|
Nephropathy, Chronic | 4 | 3 3.0|
Glomerulus, Amyloid Deposition | | 1 4.0|
Interstitial Tissue, Mineralization | | 1 1.0|
Renal Tubule, Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Lymphocyte | | 2 2.5|
Inflammation, Granulomatous | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 4| 9| 0| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 7| 3| 3| 3| 3|
| 3| 3| 3| 3| 3| 9| 9| 9| 3| 3| 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.05% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A A A + M + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + A A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + A A A + + + + + + + + + + + + + + + + +|
Ileum, Peyer's Patch, Foreign Body | |
Ileum, Peyer's Patch, Hyperplasia, | |
Lymphoid | |
Ileum, Peyer's Patch, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 |
Hematopoietic Cell Proliferation | 3 |
Infiltration Cellular, Lymphocyte | 2 3 |
Inflammation, Suppurative | 4 |
Mitotic Alteration | |
Nuclear Alteration | |
Thrombosis | X |
Hepatocyte, Atrophy, Focal | 4 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Suppurative | 4 |
Fat, Necrosis, Focal | 2 |
__________________________________________________________________________|
Pancreas | + + + + + A A + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 3 |
Inflammation, Suppurative | |
Acinus, Atrophy, Multifocal | |
Acinus, Hyperplasia | 4 |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + M + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Stomach | + + + + + A + + + + + + + M + + + + + + + + + + +|
Forestomach, Inflammation, | |
Suppurative | 3 3 |
Forestomach, Ulcer | 3 |
__________________________________________________________________________|
Tooth | |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Cortex, Degeneration, Fatty, Focal | 3 |
Medulla, Degeneration, Fatty | 4 |
Spindle Cell, Hyperplasia, Multifocal| 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + A A + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 4| 9| 0| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 7| 3| 3| 3| 3|
| 3| 3| 3| 3| 3| 9| 9| 9| 3| 3| 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.05% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + I + + + A + I + + + + + + + M + + + + + M + + +|
Pars Distalis, Angiectasis | 3 4 |
Pars Distalis, Hyperplasia, Focal | 2 2 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 2 |
Hyperplasia, Cystic | |
Follicular Cell, Hyperplasia, Diffuse| 3 |
Follicular Cell, Hyperplasia, | |
Multifocal | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | I + + + + + + + + + + M + M + + + + + M + + + + +|
Cyst | 4 3 3 3 X 3 3 3 2 3 |
Inflammation, Suppurative | 4 4 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 4 4 4 4 2 3 4 4 4 4 4 4 4 4 3 4 4 3 2 3 4 3|
Inflammation, Suppurative | 2 3 3 |
Wall, Thrombosis | |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + A + + + + + + + + + + I + + + + + + + +|
Myelofibrosis | 4 3 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Lymphoid | |
Lumbar, Hyperplasia, Lymphoid | 3 |
Mandibular, Hyperplasia, Lymphoid | |
Mediastinal, Inflammation, | |
Suppurative | 4 |
Mesenteric, Angiectasis | 3 |
Mesenteric, Hematopoietic Cell | |
Proliferation | 3 |
Mesenteric, Hyperplasia, Lymphoid | 3 3|
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + A + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hematopoietic Cell Proliferation | 3 3 |
Hyperplasia, Lymphoid | 3 3 3 3 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 4| 9| 0| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 7| 3| 3| 3| 3|
| 3| 3| 3| 3| 3| 9| 9| 9| 3| 3| 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.05% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M + + M + +|
Hyperplasia, Lymphoid | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia, Lobular | 3 |
Inflammation, Suppurative | 4 |
Duct, Ectasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mast Cell | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
__________________________________________________________________________|
Skeletal Muscle | |
Mineralization | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + A + + M + + + + + + + + + + + + + + + +|
Corpora Amylacea | X X X X X |
Meninges, Infiltration Cellular, | |
Lymphocyte | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 4 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Mediastinum, Inflammation, | |
Suppurative | 4 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Cyst | |
Hydronephrosis | 4 |
Infiltration Cellular, Lymphocyte | 3 3 2 2 3 3 2 2 2 2 3 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 4| 9| 0| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 7| 3| 3| 3| 3|
| 3| 3| 3| 3| 3| 9| 9| 9| 3| 3| 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.05% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Metaplasia, Osseous | 2 |
Nephropathy, Chronic | 2 4 2 3|
Glomerulus, Amyloid Deposition | 4|
Interstitial Tissue, Mineralization | 1 3 |
Renal Tubule, Dilatation | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + A + A + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 4 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 6| 6| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 7| 4| 3| 3| 3| 4| 2| 3| 3| 3| 8| 3| 3| 3| 3| 4| 6| 6| 3| 3| |
| 6| 4| 4| 4| 4| 6| 0| 4| 4| 4| 6| 9| 4| 4| 4| 1| 4| 4| 4| 4| 0| 6| 7| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.05% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + A A + + + + + + + + A + + + + M + + + +| 41 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + + + + + + A + + + + + + + + +| 45 |
Ileum, Peyer's Patch, Foreign Body | 3 | 1 3.0|
Ileum, Peyer's Patch, Hyperplasia, | | |
Lymphoid | 3 | 1 3.0|
Ileum, Peyer's Patch, Inflammation, | | |
Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 2.5|
Hematopoietic Cell Proliferation | 3 3 3 | 4 3.0|
Infiltration Cellular, Lymphocyte | 2 2 3 | 5 2.4|
Inflammation, Suppurative | 3 | 2 3.5|
Mitotic Alteration | 3 | 1 3.0|
Nuclear Alteration | 3 | 1 3.0|
Thrombosis | | 1 |
Hepatocyte, Atrophy, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Inflammation, Suppurative | | 1 4.0|
Fat, Necrosis, Focal | 3 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Infiltration Cellular, Lymphocyte | | 1 3.0|
Inflammation, Suppurative | 3 3 | 2 3.0|
Acinus, Atrophy, Multifocal | 4 | 1 4.0|
Acinus, Hyperplasia | | 1 4.0|
Duct, Cyst | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Forestomach, Inflammation, | | |
Suppurative | | 2 3.0|
Forestomach, Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Dysplasia | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 6| 6| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 7| 4| 3| 3| 3| 4| 2| 3| 3| 3| 8| 3| 3| 3| 3| 4| 6| 6| 3| 3| |
| 6| 4| 4| 4| 4| 6| 0| 4| 4| 4| 6| 9| 4| 4| 4| 1| 4| 4| 4| 4| 0| 6| 7| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.05% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cortex, Degeneration, Fatty, Focal | 2 | 2 2.5|
Medulla, Degeneration, Fatty | | 1 4.0|
Spindle Cell, Hyperplasia, Multifocal| | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + M M + + + + + + + + + + + M + + + +| 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + A + + + + + + + + + + + + + + + + + + +| 44 |
Pars Distalis, Angiectasis | 3 | 3 3.3|
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 | 8 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 3 3 | 5 2.6|
Hyperplasia, Cystic | 2 | 1 2.0|
Follicular Cell, Hyperplasia, Diffuse| | 1 3.0|
Follicular Cell, Hyperplasia, | | |
Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + M + + + + + +| 45 |
Cyst | X X X X X X X X X X | 20 3.0|
Inflammation, Suppurative | 4 4 4 | 6 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 4 4 4 3 4 3 2 4 3 3 3 3 4 3 4 4 4 3 4 4 3 2 4 4 3| 48 3.5|
Inflammation, Suppurative | 2 2 3 3 4 4 | 9 2.9|
Wall, Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | M + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Myelofibrosis | 3 | 3 3.3|
Myeloid Cell, Hyperplasia | 4 4 3 | 3 3.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Iliac, Hyperplasia, Lymphoid | 3 | 1 3.0|
Lumbar, Hyperplasia, Lymphoid | | 1 3.0|
Mandibular, Hyperplasia, Lymphoid | 4 | 1 4.0|
Mediastinal, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 6| 6| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 7| 4| 3| 3| 3| 4| 2| 3| 3| 3| 8| 3| 3| 3| 3| 4| 6| 6| 3| 3| |
| 6| 4| 4| 4| 4| 6| 0| 4| 4| 4| 6| 9| 4| 4| 4| 1| 4| 4| 4| 4| 0| 6| 7| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.05% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Suppurative | | 1 4.0|
Mesenteric, Angiectasis | | 1 3.0|
Mesenteric, Hematopoietic Cell | | |
Proliferation | 3 | 2 3.0|
Mesenteric, Hyperplasia, Lymphoid | 3 | 3 3.0|
Renal, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 3.0|
Hematopoietic Cell Proliferation | 4 4 3 3 4 | 7 3.4|
Hyperplasia, Lymphoid | 3 | 5 3.0|
Pigmentation | 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + M + M + + + + + + + + + +| 47 |
Hyperplasia, Lobular | | 1 3.0|
Inflammation, Suppurative | | 1 4.0|
Duct, Ectasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mast Cell | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | X X | 2 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Mineralization | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Corpora Amylacea | X | 6 |
Meninges, Infiltration Cellular, | | |
Lymphocyte | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 3| 2 3.5|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 3 2 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 6| 6| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 7| 4| 3| 3| 3| 4| 2| 3| 3| 3| 8| 3| 3| 3| 3| 4| 6| 6| 3| 3| |
| 6| 4| 4| 4| 4| 6| 0| 4| 4| 4| 6| 9| 4| 4| 4| 1| 4| 4| 4| 4| 0| 6| 7| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.05% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mediastinum, Inflammation, | | |
Suppurative | 3 | 3 3.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 4.0|
Cyst | X | 1 |
Hydronephrosis | | 1 4.0|
Infiltration Cellular, Lymphocyte | 3 2 3 4 2 3 3 2 2 2 3 2 2 3 3 3 3 2| 29 2.6|
Inflammation, Chronic | 4 | 1 4.0|
Metaplasia, Osseous | | 1 2.0|
Nephropathy, Chronic | 2 | 5 2.6|
Glomerulus, Amyloid Deposition | | 1 4.0|
Interstitial Tissue, Mineralization | | 2 2.0|
Renal Tubule, Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + I + + + + + + + + + + + + + + + + + +| 47 |
Infiltration Cellular, Lymphocyte | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 3| 3| 3| 3| 7| 6| 3| 3| 3|
| 9| 4| 4| 4| 4| 0| 4| 4| 4| 4| 6| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Gallbladder | + + M + + A M M + + + A + + + + + M + M M + M M M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + A + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + A + + + + + A + + + + + + + + A + + + +|
Ileum, Peyer's Patch, Hyperplasia, | |
Lymphoid | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + A + + + +|
Basophilic Focus | |
Cyst | X X |
Cytoplasmic Alteration, Focal | |
Hematopoietic Cell Proliferation | |
Infiltration Cellular, Lymphocyte | 2 |
Necrosis | 4 4 |
__________________________________________________________________________|
Mesentery | + |
Hemorrhage | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + A + + + + + + + + A + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + A + + + +|
Cyst | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + M + + + + + + + + A + + + +|
Forestomach, Edema | 2 |
__________________________________________________________________________|
Tooth | |
Dysplasia | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + A + + + +|
Medulla, Hyperplasia, Focal | 2 |
Spindle Cell, Hyperplasia, Focal | 3 2 2 4 |
Spindle Cell, Hyperplasia, Multifocal| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + A + + + + + + + + A + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M M + + + + + + + M + + + + M|
__________________________________________________________________________|
Pituitary Gland | M + + + I + M + + + + + + + + + M + + + A + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 3 3 3 |
Hyperplasia, Cystic | 2 4 |
Infiltration Cellular, Lymphocyte | 2|
Follicle, Cyst | X X |
Follicular Cell, Hyperplasia, Focal | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 3| 3| 3| 3| 7| 6| 3| 3| 3|
| 9| 4| 4| 4| 4| 0| 4| 4| 4| 4| 6| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Preputial Gland | + + M + + |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | |
Inflammation, Suppurative | 4 4 4 |
Mineralization | |
Duct, Ectasia | 2 |
Duct, Inflammation, Suppurative | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + M + + A + + + +|
__________________________________________________________________________|
Seminal Vesicle | + |
Atrophy | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + A + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + A + + + +|
Angiectasis | |
Myelofibrosis | |
Myeloid Cell, Hyperplasia | 4 4 4 3 4 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | 3 |
Inguinal, Hyperplasia, Plasma Cell | 3 |
Inguinal, Pigmentation | 3 3 |
Inguinal, Renal, Iliac, Autolysis | 4 |
Mandibular, Hyperplasia, Lymphoid | 3 |
Mesenteric, Angiectasis | 3 3 3 3 4 4 4 4 |
Mesenteric, Hematopoietic Cell | |
Proliferation | 3 3 3 3 |
Mesenteric, Hyperplasia, Lymphoid | 3 3 3 |
Mesenteric, Syncytial Alteration | |
Renal, Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + A + + + +|
Atrophy | 3 |
Hematopoietic Cell Proliferation | 4 4 4 4 4 |
Hyperplasia, Lymphoid | 3 |
Lymphoid Follicle, Amyloid Deposition| |
__________________________________________________________________________|
Thymus | M + + + + + + M M + + M + + + + M + M M M M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M + M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + A + + + + + + + + A + + + +|
Fibrosis, Focal | 3 3 3 4 3 |
Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 3| 3| 3| 3| 7| 6| 3| 3| 3|
| 9| 4| 4| 4| 4| 0| 4| 4| 4| 4| 6| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic, Focal | 3 |
Inflammation, Focal, Suppurative | 4 |
Mineralization | |
Necrosis, Focal | 3 |
Ulcer, Focal | 3 |
Subcutaneous Tissue, Abscess, Chronic| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpora Amylacea | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Lymphocyte | |
Alveolar Epithelium, Hyperplasia, | |
Diffuse | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 3 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | |
__________________________________________________________________________|
Nose | + + + + + M + + + + + + + + + + + + + + M + + + +|
Lumen, Inflammation, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + A + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
__________________________________________________________________________|
Harderian Gland | + + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 3 2 2 2 2 3 2 3 2 2|
Nephropathy, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Interstitial Tissue, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + A + + + +|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 6| 6| 3| 3| 3| 0| 3| 3| 3| 3| 7| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 0| 3| 3| |
| 4| 7| 4| 4| 5| 5| 5| 5| 5| 5| 9| 9| 5| 5| 5| 8| 5| 5| 5| 5| 9| 4| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + M M M + M + + + A M M + + + + + M + + + + + +| 31 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + A + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + A + + + + + + + + + + + + + +| 46 |
Ileum, Peyer's Patch, Hyperplasia, | | |
Lymphoid | 3 | 2 3.5|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | X X | 2 |
Cyst | X | 3 |
Cytoplasmic Alteration, Focal | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 4 | 1 4.0|
Infiltration Cellular, Lymphocyte | 3 | 2 2.5|
Necrosis | | 2 4.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Forestomach, Edema | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + + + + | 4 |
Dysplasia | X X X X | 4 |
Inflammation, Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Medulla, Hyperplasia, Focal | | 1 2.0|
Spindle Cell, Hyperplasia, Focal | | 4 2.8|
Spindle Cell, Hyperplasia, Multifocal| 3 | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + M + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + M + + + M + + + + + + + + M + + + + +| 41 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 3 3 2 4 2 3 2 3 | 13 2.8|
Hyperplasia, Cystic | 3| 3 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 6| 6| 3| 3| 3| 0| 3| 3| 3| 3| 7| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 0| 3| 3| |
| 4| 7| 4| 4| 5| 5| 5| 5| 5| 5| 9| 9| 5| 5| 5| 8| 5| 5| 5| 5| 9| 4| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Infiltration Cellular, Lymphocyte | 3 | 2 2.5|
Follicle, Cyst | | 2 |
Follicular Cell, Hyperplasia, Focal | 3 3 | 3 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + +| 12 |
Infiltration Cellular, Lymphocyte | 4 | 1 4.0|
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Suppurative | 3 4 3 | 6 3.7|
Mineralization | 3 | 1 3.0|
Duct, Ectasia | 2 3 3 3 3 3| 7 2.7|
Duct, Inflammation, Suppurative | 3| 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + M + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Seminal Vesicle | | 1 |
Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 3 | 1 3.0|
Myelofibrosis | 3 | 1 3.0|
Myeloid Cell, Hyperplasia | 4 4 4 | 9 3.9|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Hyperplasia, Lymphoid | 3 | 2 3.0|
Inguinal, Hyperplasia, Plasma Cell | | 1 3.0|
Inguinal, Pigmentation | | 2 3.0|
Inguinal, Renal, Iliac, Autolysis | | 1 4.0|
Mandibular, Hyperplasia, Lymphoid | 3 | 2 3.0|
Mesenteric, Angiectasis | 3 2 4 3 3 | 13 3.3|
Mesenteric, Hematopoietic Cell | | |
Proliferation | 3 3 3 | 7 3.0|
Mesenteric, Hyperplasia, Lymphoid | 3 3 3 3 3 | 8 3.0|
Mesenteric, Syncytial Alteration | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 6| 6| 3| 3| 3| 0| 3| 3| 3| 3| 7| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 0| 3| 3| |
| 4| 7| 4| 4| 5| 5| 5| 5| 5| 5| 9| 9| 5| 5| 5| 8| 5| 5| 5| 5| 9| 4| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 3.0|
Hematopoietic Cell Proliferation | 3 3 4 4 3 2 4 4 4 | 14 3.6|
Hyperplasia, Lymphoid | 3 3 | 3 3.0|
Lymphoid Follicle, Amyloid Deposition| 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + M + + + M M M M + + M M + + + M M + + M + + + +| 31 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Fibrosis, Focal | 2 4 3 3 4 2 3 3 2 2 3 2| 17 2.9|
Hyperplasia, Focal | | 1 2.0|
Inflammation, Chronic, Focal | 3 | 2 3.0|
Inflammation, Focal, Suppurative | 3 3 | 3 3.3|
Mineralization | 3 | 1 3.0|
Necrosis, Focal | | 1 3.0|
Ulcer, Focal | 3 4 4 2 | 5 3.2|
Subcutaneous Tissue, Abscess, Chronic| 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Corpora Amylacea | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Infiltration Cellular, Lymphocyte | 4 | 1 4.0|
Alveolar Epithelium, Hyperplasia, | | |
Diffuse | 4 | 1 4.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 3| 3 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 6| 6| 3| 3| 3| 0| 3| 3| 3| 3| 7| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 0| 3| 3| |
| 4| 7| 4| 4| 5| 5| 5| 5| 5| 5| 9| 9| 5| 5| 5| 8| 5| 5| 5| 5| 9| 4| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Lumen, Inflammation, Suppurative | 3 | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 5 |
__________________________________________________________________________|____________|
Harderian Gland | + + + | 8 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 3 2 2 3 3 2 3 2 3 3 2 2| 23 2.4|
Nephropathy, Chronic | 1 4 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1| 38 1.1|
Interstitial Tissue, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 37 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
_____________________________________________________________________________________________________________________
| 3| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 9| 2| 2| 9| 0| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 5| 9| 9| 9| 9| 5| 9| 9| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A M + + M M + + + + M + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Large | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + + + + + +|
Ileum, Peyer's Patch, Hyperplasia, | |
Lymphoid | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 3 |
Hemorrhage, Chronic | 4 |
Inflammation, Granulomatous | 2 |
Necrosis | 4 |
Pigmentation, Hemosiderin | 2 3 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Focal | 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Cyst | |
Forestomach, Ulcer | |
Glandular, Mineralization | |
__________________________________________________________________________|
Tooth | + |
Dysplasia | |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Medulla, Hyperplasia, Multifocal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + M + + + + + + M + + M + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + M M + + + + + + + + + + + + + + + + + + I|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 3 3 3 |
Hyperplasia, Cystic | 2 |
C-Cell, Hyperplasia, Focal | 2 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia, Focal | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
_____________________________________________________________________________________________________________________
| 3| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 9| 2| 2| 9| 0| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 5| 9| 9| 9| 9| 5| 9| 9| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + |
Fibrosis | 4 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | 4 |
Inflammation, Granulomatous | 4 |
Inflammation, Suppurative | 4 3 4 4 4 |
Metaplasia, Osseous | 2 |
Mineralization | 2 3 |
Duct, Ectasia | 3 3 3 3 3 4 4 3 3 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Myeloid Cell, Hyperplasia | 4 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | 2 4 3 |
Inguinal, Pigmentation | |
Mandibular, Hyperplasia, Lymphoid | 3 |
Mandibular, Pigmentation | |
Mesenteric, Angiectasis | 3 3 |
Mesenteric, Hematopoietic Cell | |
Proliferation | 3 |
Mesenteric, Hyperplasia, Lymphoid | 3 |
Pancreatic, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 4 3 4 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M + M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 3 3 3 3 2 3 3 2 |
Inflammation, Chronic, Focal | 2 3 |
Inflammation, Focal, Suppurative | |
Mineralization | 3 |
Ulcer, Focal | |
Subcutaneous Tissue, Abscess, Chronic| 4 |
Subcutaneous Tissue, Edema | 3 |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
_____________________________________________________________________________________________________________________
| 3| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 9| 2| 2| 9| 0| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 5| 9| 9| 9| 9| 5| 9| 9| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpora Amylacea | 2 X X|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 3 |
Infiltration Cellular, Lymphocyte | 3 |
Necrosis, Diffuse | |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 4 |
Bronchus, Foreign Body | 3 |
Bronchus, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Nose | M + M + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Foreign Body | 2 2 2 |
Lumen, Inflammation, Suppurative | 3 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Infarct | |
Infiltration Cellular, Lymphocyte | 3 2 3 2 2 3 3 2 2 2|
Inflammation, Suppurative | |
Nephropathy, Chronic | 1 1 1 1 1 2 2 2 2 2 2 2 1 2 2 1 2 1 2 1 1 1|
Cortex, Fibrosis | |
Interstitial Tissue, Mineralization | 1 1 1 1 1 2 1 1 1 1 1 2 2 1 1 2 2 2 1 1 1 2|
Interstitial Tissue, Pigmentation | 1 |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Proliferative | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 3| 3| 4| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9| 3| 3| 3| 3| 7| 9| 3| 3| 3| 2| 9| 3| 3| 3| |
| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 5| 0| 0| 0| 0| 4| 2| 9| 0| 0| 2| 8| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.2% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | A + + + M + + + + + M + + + + A A + + + + M + + +| 38 |
__________________________________________________________________________|____________|
Intestine Large | A + + + + + + + + + + + + + + A A + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small | A + + + + + + + + + A + + + + A A + + + + + + + +| 45 |
Ileum, Peyer's Patch, Hyperplasia, | | |
Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | 4 | 2 3.5|
Hemorrhage, Chronic | | 1 4.0|
Inflammation, Granulomatous | | 1 2.0|
Necrosis | | 1 4.0|
Pigmentation, Hemosiderin | | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | + + + | 5 |
Fat, Necrosis, Focal | 3 3 | 4 3.5|
__________________________________________________________________________|____________|
Pancreas | A + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Forestomach, Cyst | X | 1 |
Forestomach, Ulcer | 2 | 1 2.0|
Glandular, Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + + + + | 5 |
Dysplasia | X X | 2 |
Inflammation, Suppurative | 3 3 | 3 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Medulla, Hyperplasia, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | A + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M M + + + + + M + + M M + + +| 41 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + I I + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 3 2 2 2 3| 9 2.7|
Hyperplasia, Cystic | 3 3 3 3| 5 2.8|
C-Cell, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 3| 3| 4| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9| 3| 3| 3| 3| 7| 9| 3| 3| 3| 2| 9| 3| 3| 3| |
| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 5| 0| 0| 0| 0| 4| 2| 9| 0| 0| 2| 8| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.2% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + +| 25 |
Fibrosis | | 1 4.0|
Infiltration Cellular, Lymphocyte | 4 3 | 2 3.5|
Inflammation, Chronic | 4 | 2 4.0|
Inflammation, Granulomatous | 3 4 | 3 3.7|
Inflammation, Suppurative | 3 4 4| 8 3.8|
Metaplasia, Osseous | | 1 2.0|
Mineralization | | 2 2.5|
Duct, Ectasia | 3 4 3 3 4 4| 17 3.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 2 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 3 2 3| 3 2.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Myeloid Cell, Hyperplasia | 4 4 4 | 5 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Hyperplasia, Lymphoid | 3 3 3 2 3 3| 9 2.9|
Inguinal, Pigmentation | 3 | 1 3.0|
Mandibular, Hyperplasia, Lymphoid | 3 | 2 3.0|
Mandibular, Pigmentation | 3 | 1 3.0|
Mesenteric, Angiectasis | 4 | 3 3.3|
Mesenteric, Hematopoietic Cell | | |
Proliferation | | 1 3.0|
Mesenteric, Hyperplasia, Lymphoid | 3 | 2 3.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | A + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 4 | 6 3.5|
Hyperplasia, Lymphoid | 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 3| 3| 4| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9| 3| 3| 3| 3| 7| 9| 3| 3| 3| 2| 9| 3| 3| 3| |
| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 5| 0| 0| 0| 0| 4| 2| 9| 0| 0| 2| 8| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.2% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M + + + + M M + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | 3 3 3 3 3 2 2 2 3 3 2 4 3 3 3 2| 24 2.8|
Inflammation, Chronic, Focal | 3 4 | 4 3.0|
Inflammation, Focal, Suppurative | 3 | 1 3.0|
Mineralization | | 1 3.0|
Ulcer, Focal | 4 | 1 4.0|
Subcutaneous Tissue, Abscess, Chronic| | 1 4.0|
Subcutaneous Tissue, Edema | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Corpora Amylacea | X 2 X X X X 2 | 10 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Hemorrhage | | 1 3.0|
Infiltration Cellular, Lymphocyte | | 1 3.0|
Necrosis, Diffuse | 4 | 1 4.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | | 1 4.0|
Bronchus, Foreign Body | | 1 3.0|
Bronchus, Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Nose | M + + + + + + + + + M + + + + M M M + + + + + + +| 43 |
Lumen, Foreign Body | 2 3 | 5 2.2|
Lumen, Inflammation, Suppurative | 2 2 | 5 2.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 3| 3| 4| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9| 3| 3| 3| 3| 7| 9| 3| 3| 3| 2| 9| 3| 3| 3| |
| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 5| 0| 0| 0| 0| 4| 2| 9| 0| 0| 2| 8| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.2% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bacterium | 4 4 | 2 4.0|
Infarct | 3 | 1 3.0|
Infiltration Cellular, Lymphocyte | 3 2 2 2 3 2 2 2| 18 2.3|
Inflammation, Suppurative | 4 4 | 2 4.0|
Nephropathy, Chronic | 1 1 1 1 1 2 1 1 2 1 2 2 1 1 1 1 1 1 3 1| 42 1.4|
Cortex, Fibrosis | 4 | 1 4.0|
Interstitial Tissue, Mineralization | 1 2 2 1 1 2 1 1 1 1 1 2 1 1 2 2 1 2| 40 1.4|
Interstitial Tissue, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + A A + + + + + + + +| 48 |
Inflammation, Proliferative | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 3| 6| 3| 3| 3| 4| 3| 2| 3| 3| 8| 7| 3| 3| 3| 4| 9| 0| 3| 3| 0| 6| 2| 3| 3|
| 8| 4| 3| 3| 3| 4| 5| 9| 3| 3| 3| 3| 3| 3| 3| 5| 8| 7| 3| 3| 2| 6| 9| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.1% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M M + + + + A + + + + + M + + M M M + + M M + + M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + |
__________________________________________________________________________|
Intestine Small, Ileum | + |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | X |
Hematopoietic Cell Proliferation | 2 2 |
Mineralization | 3 |
Necrosis | 4 4 4 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Focal | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Multifocal | |
Acinus, Hyperplasia | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Cyst | X |
Forestomach, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Tooth | |
Dysplasia | |
Inflammation, Chronic | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Cortex, Hyperplasia, Focal | 3 |
Spindle Cell, Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + I + + + + M + + + + + + + + + M + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 2 2 2 2 3 3|
Hyperplasia, Cystic | 3 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 3| 6| 3| 3| 3| 4| 3| 2| 3| 3| 8| 7| 3| 3| 3| 4| 9| 0| 3| 3| 0| 6| 2| 3| 3|
| 8| 4| 3| 3| 3| 4| 5| 9| 3| 3| 3| 3| 3| 3| 3| 5| 8| 7| 3| 3| 2| 6| 9| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.1% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Hyperplasia, Focal | 2 4 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + M + + + + + + + + + + + + + + + + + + +|
Inflammation, Diffuse, Suppurative | 4 |
__________________________________________________________________________|
Preputial Gland | + M + + + M + + + + + + |
Inflammation, Suppurative | 4 4 4 4 4 4 |
Duct, Ectasia | 3 4 3 3 4 2 3 3 4 |
__________________________________________________________________________|
Prostate | + + + + + M + + + + M + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Seminal Vesicle | + |
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + M + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | M M M |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 4 4 4 4 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | 3 |
Inguinal, Necrosis | 2 |
Mesenteric, Angiectasis | 3 3 3 4 |
Mesenteric, Hematopoietic Cell | |
Proliferation | 3 |
Mesenteric, Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 4 4 3 3 3 4 4 4 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | M M + + + + M M + + M + M + + + + + + + M + + + +|
Hyperplasia, Lymphoid | 4 |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Fibrosis, Focal | 3 3 3 2 3 3 2 2 2 2 2 2|
Hemorrhage, Multifocal | 3 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 3| 6| 3| 3| 3| 4| 3| 2| 3| 3| 8| 7| 3| 3| 3| 4| 9| 0| 3| 3| 0| 6| 2| 3| 3|
| 8| 4| 3| 3| 3| 4| 5| 9| 3| 3| 3| 3| 3| 3| 3| 5| 8| 7| 3| 3| 2| 6| 9| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.1% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hyperplasia, Focal | |
Inflammation, Chronic | 3 |
Inflammation, Focal, Suppurative | 3 4 |
Mineralization | |
Necrosis, Focal | 4 |
Ulcer, Focal | 4 2 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpora Amylacea | X X X|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Embolus Tumor | |
Hemorrhage | |
Necrosis, Multifocal | |
Alveolar Epithelium, Hyperplasia, | |
Diffuse | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + M + + + + + + + + + M + + + +|
Lumen, Foreign Body | 3 |
Submucosa, Sinus, Inflammation, | |
Granulomatous, Suppurative | 4 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | 3 |
Hydronephrosis | |
Infarct | 3 |
Infiltration Cellular, Lymphocyte | 2 2 2 1 2 3 3 2 2 |
Inflammation, Suppurative | 3 |
Nephropathy, Chronic | 1 1 1 2 2 1 1 1 1 1 1 1 2 2 2|
Cortex, Cyst | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 3| 6| 3| 3| 3| 4| 3| 2| 3| 3| 8| 7| 3| 3| 3| 4| 9| 0| 3| 3| 0| 6| 2| 3| 3|
| 8| 4| 3| 3| 3| 4| 5| 9| 3| 3| 3| 3| 3| 3| 3| 5| 8| 7| 3| 3| 2| 6| 9| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.1% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Corticomedullary Junction, Fibrosis | |
Interstitial Tissue, Mineralization | 1 1 1 2 1 1 1 2 2 1 2 1 2 2 |
Medulla, Cyst | X |
Renal Tubule, Dilatation | 3 |
__________________________________________________________________________|
Urethra | + |
Inflammation | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + M + + + +|
Mucosa, Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 2| 0| 3| 3| 3| 7| 6| 3| 3| 3| |
| 1| 3| 3| 3| 3| 1| 7| 3| 3| 3| 3| 3| 9| 3| 3| 5| 7| 3| 3| 3| 9| 3| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.1% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + A A M + + M + + + M + M M M + + M + + M| 30 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + A A + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A A + + + + + + + + + + + + + + A + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 3.0|
Cyst | | 1 |
Hematopoietic Cell Proliferation | 2 | 3 2.0|
Mineralization | | 1 3.0|
Necrosis | 3 | 4 3.8|
__________________________________________________________________________|____________|
Mesentery | + + + | 5 |
Fat, Necrosis, Focal | 3 | 3 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy, Multifocal | 4 | 1 4.0|
Acinus, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Forestomach, Cyst | | 1 |
Forestomach, Inflammation, | | |
Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + + + | 3 |
Dysplasia | X X X | 3 |
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Suppurative | 4 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
Cortex, Hyperplasia, Focal | | 1 3.0|
Spindle Cell, Hyperplasia, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + M + M + + + + + + + + M + + M + M + M +| 40 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 2| 0| 3| 3| 3| 7| 6| 3| 3| 3| |
| 1| 3| 3| 3| 3| 1| 7| 3| 3| 3| 3| 3| 9| 3| 3| 5| 7| 3| 3| 3| 9| 3| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.1% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + A + + + + + + + + M I + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Cystic | 3 2 4 2 3 | 12 2.6|
Hyperplasia, Cystic | 3 | 2 3.0|
Follicle, Cyst | X | 1 |
Follicular Cell, Hyperplasia, Focal | 2 | 4 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Diffuse, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 15 |
Inflammation, Suppurative | 4 3 4 4 | 10 3.9|
Duct, Ectasia | 3 3 4 | 12 3.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Granulomatous | 3 | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 2 |
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + A A + + + + + + + + + + + + + + + + + +| 47 |
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | M | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Myeloid Cell, Hyperplasia | 4 4 | 7 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Hyperplasia, Lymphoid | 3 | 2 3.0|
Inguinal, Necrosis | | 1 2.0|
Mesenteric, Angiectasis | 4 4 4 4 | 8 3.6|
Mesenteric, Hematopoietic Cell | | |
Proliferation | | 1 3.0|
Mesenteric, Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 3 4 3 4 4 | 13 3.6|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 2| 0| 3| 3| 3| 7| 6| 3| 3| 3| |
| 1| 3| 3| 3| 3| 1| 7| 3| 3| 3| 3| 3| 9| 3| 3| 5| 7| 3| 3| 3| 9| 3| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.1% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + M + M + + + + M +| 40 |
Hyperplasia, Lymphoid | | 1 4.0|
Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M + M M M M M M M M M M M M| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 |
Fibrosis, Focal | 3 2 2 2 1 3 2 2 2 3 3 2 3| 25 2.4|
Hemorrhage, Multifocal | | 1 3.0|
Hyperplasia, Focal | 2 | 1 2.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Focal, Suppurative | | 2 3.5|
Mineralization | 3 | 1 3.0|
Necrosis, Focal | | 1 4.0|
Ulcer, Focal | 3 | 4 2.8|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Corpora Amylacea | X X X X X X X X X| 12 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 4 | 1 4.0|
Embolus Tumor | X | 1 |
Hemorrhage | 4 | 1 4.0|
Necrosis, Multifocal | 4 | 1 4.0|
Alveolar Epithelium, Hyperplasia, | | |
Diffuse | 4 | 1 4.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + M + + + + + + + + + + + + + + M + + + +| 46 |
Lumen, Foreign Body | | 1 3.0|
Submucosa, Sinus, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05048-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 16:54:14
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 2| 0| 3| 3| 3| 7| 6| 3| 3| 3| |
| 1| 3| 3| 3| 3| 1| 7| 3| 3| 3| 3| 3| 9| 3| 3| 5| 7| 3| 3| 3| 9| 3| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.1% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Granulomatous, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Focal | | 1 3.0|
Hydronephrosis | 4 | 1 4.0|
Infarct | | 1 3.0|
Infiltration Cellular, Lymphocyte | 1 3 2 3 2 1 2 2 3 2 3 2 2 2| 23 2.1|
Inflammation, Suppurative | 2 | 2 2.5|
Nephropathy, Chronic | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 34 1.2|
Cortex, Cyst | 3 | 1 3.0|
Corticomedullary Junction, Fibrosis | 4 | 1 4.0|
Interstitial Tissue, Mineralization | 1 1 2 1 1 2 2 1 1 1 2 1 1 1 2 2 1 2 1 1| 34 1.4|
Medulla, Cyst | | 1 |
Renal Tubule, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
Mucosa, Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
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