TR 364 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/07/94
EXP: 05048 RHODAMINE 6G TIME: 01:51:04
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 56122
CONT: N01-ES-28024 CAS: 989-38-8
PATHOLOGIST: R. THOMPSON
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/07/94
EXP: 05048 RHODAMINE 6G TIME: 01:51:04
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 56122
CONT: N01-ES-28024 CAS: 989-38-8
PATHOLOGIST: R. THOMPSON
RHODAMINE 6G
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATD CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 90 474 546 579 620 634 639 664 664 664 |
| 667 705 705 708 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.1% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 1 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 431 479 483 502 573 621 625 635 638 645 |
| 663 664 666 698 707 707 727 |
| CENSORED DEATHS |
| 544 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.2% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 374 385 392 395 433 439 522 698 699 699 |
| 705 706 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
RHODAMINE 6G
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATD | 98.0 98.0 98.0 98.0 98.0 96.0 96.0 92.0 80.0 72.0 |
|CONTROL | |
| | |
|0.1% | 100.0 100.0 100.0 100.0 100.0 94.0 92.0 90.0 75.6 65.4 |
| | |
| | |
|0.2% | 100.0 100.0 100.0 100.0 92.0 88.0 86.0 86.0 86.0 76.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATD 0.1% 0.2% |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 72.0% 65.4% 76.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.804N P=0.588 P=0.863N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 597.1 615.5 537.3 |
|NATURAL DEATHS (C) | (42.8) (21.9) (43.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 692.1 686.7 683.0 |
|(STANDARD ERROR) | (14.4) (10.9) (15.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
RHODAMINE 6G
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATD CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 570 591 630 655 663 664 682 693 695 721 |
| 724 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.05% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 440 546 576 581 640 649 666 666 667 677 |
| 693 699 706 709 725 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.1% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 459 583 599 613 635 638 642 686 694 695 |
| 695 698 725 728 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
RHODAMINE 6G
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATD | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 96.0 88.0 78.0 |
|CONTROL | |
| | |
|0.05% | 100.0 100.0 100.0 100.0 100.0 98.0 98.0 92.0 88.0 70.0 |
| | |
| | |
|0.1% | 100.0 100.0 100.0 100.0 100.0 98.0 98.0 94.0 86.0 72.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATD 0.05% 0.1% |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 78.0% 70.0% 72.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.569 P=0.467 P=0.630 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 662.5 642.7 649.3 |
|NATURAL DEATHS (C) | (14.9) (19.8) (19.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 714.4 703.1 706.7 |
|(STANDARD ERROR) | ( 5.0) ( 8.1) ( 7.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
RHODAMINE 6G
KAPLAN-MEIER SURVIVAL CURVES
UNTREATD CONTROL = 1
0.1% = 2
0.2% = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3 2
|
| 1 3 3 2 12
| 33 1 1
95 +
| 33 2 2 1 1
P | 3 3 2 21 1
E |
R 90 + 33 2 1 1
C |
E | 3 3 2211
N | 3 221 1 3
T 85 +
| 22
S |
U | 22
R 80 + 2 11 33
V |
I | 1 1
V | 22 3 3
A 75 +
L | 2 211
| 1 1
| 22
70 +
|
| 2 2
|
65 + 2 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 4 obs hidden.
RHODAMINE 6G
KAPLAN-MEIER SURVIVAL CURVES
UNTREATD CONTROL = 1
0.05% = 2
0.1% = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1
|
| 2 3 2 1 3 1
|
96 + 2 23 13 1
|
| 3 3 1 1
|
P 92 + 2 3 32 1 1
E |
R | 322
C |
E 88 + 2 12 1
N |
T | 3 11
|
S 84 + 311
U |
R | 22 1 1
V |
I 80 + 2 2 11
V |
A | 22 1 1
L |
76 + 22 3
|
| 22
|
72 + 2 2 3
|
| 2 2
|
68 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 7 obs hidden.
--multipart-boundary
Content-type: text/plain
Range: bytes 23867-23867/23867
--multipart-boundary--