TR 364 Rat Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
RHODAMINE 6G
NTP Experiment-Test: 05048-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/06/94
Route: DOSED FEED Time: 23:53:03
Facility: Southern Research Institute
Chemical CAS #: 989-38-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05048-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RHODAMINE 6G Date: 09/06/94
Route: DOSED FEED Time: 23:53:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.012% 0.025%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund 17 16 18
Dead 4 4 2
Survivors
Terminal Sacrifice 29 30 30
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small (50) (49) (50)
Liver (50) (49) (50)
Neoplastic Nodule 1 (2%)
Sarcoma 1 (2%)
Pancreas (48) (49) (50)
Adenoma 1 (2%)
Salivary Glands (50) (49) (49)
Stomach (50) (50) (50)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (50) (50)
Osteosarcoma, Metastatic, Bone 1 (2%)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Cortex, Adenoma 1 (2%) 3 (6%)
Medulla, Pheochromocytoma Malignant 2 (4%)
Medulla, Pheochromocytoma Benign 3 (6%) 3 (6%) 7 (14%)
Medulla, Pheochromocytoma Benign, Multiple 1 (2%)
Islets, Pancreatic (48) (49) (50)
Adenoma 2 (4%)
Carcinoma 1 (2%) 1 (2%)
Parathyroid Gland (46) (48) (46)
Adenoma 1 (2%)
Pituitary Gland (49) (49) (50)
Pars Distalis, Adenoma 31 (63%) 29 (59%) 28 (56%)
Page 2
NTP Experiment-Test: 05048-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RHODAMINE 6G Date: 09/06/94
Route: DOSED FEED Time: 23:53:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.012% 0.025%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (50) (50) (50)
C-Cell, Adenoma 4 (8%) 3 (6%) 4 (8%)
C-Cell, Carcinoma 1 (2%) 2 (4%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (42) (40) (39)
Adenoma 5 (12%) 4 (10%) 2 (5%)
Carcinoma 1 (2%) 4 (10%) 3 (8%)
Sarcoma 1 (3%)
Squamous Cell Papilloma 1 (2%)
Ovary (50) (49) (50)
Sarcoma 1 (2%)
Uterus (49) (50) (50)
Adenocarcinoma 1 (2%) 1 (2%)
Leiomyoma 1 (2%)
Polyp Stromal 7 (14%) 12 (24%) 13 (26%)
Sarcoma 1 (2%)
Sarcoma Stromal 3 (6%) 1 (2%)
Cervix, Leiomyoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (43) (42) (48)
Bone Marrow (50) (50) (50)
Sarcoma 1 (2%)
Lymph Node (50) (49) (50)
Spleen (49) (49) (50)
Thymus (43) (46) (49)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50)
Adenocarcinoma 3 (6%) 1 (2%) 2 (4%)
Adenoma 1 (2%)
Fibroadenoma 12 (24%) 12 (24%) 11 (22%)
Page 3
NTP Experiment-Test: 05048-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RHODAMINE 6G Date: 09/06/94
Route: DOSED FEED Time: 23:53:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.012% 0.025%
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Fibroadenoma, Multiple 7 (14%) 3 (6%) 6 (12%)
Sarcoma 1 (2%)
Skin (50) (50) (50)
Basal Cell Adenoma 1 (2%) 1 (2%)
Keratoacanthoma 1 (2%) 1 (2%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 2 (4%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Osteosarcoma 1 (2%) 1 (2%)
Skeletal Muscle (1)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Astrocytoma Malignant 1 (2%)
Glioma Malignant 1 (2%)
Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Osteosarcoma, Metastatic, Bone 1 (2%)
Sarcoma 2 (4%)
Nose (49) (50) (47)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (50) (50) (50)
Page 4
NTP Experiment-Test: 05048-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RHODAMINE 6G Date: 09/06/94
Route: DOSED FEED Time: 23:53:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.012% 0.025%
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 11 (22%) 11 (22%) 10 (20%)
Lymphoma Malignant Histiocytic 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05048-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RHODAMINE 6G Date: 09/06/94
Route: DOSED FEED Time: 23:53:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.012% 0.025%
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 47 49
Total Primary Neoplasms 100 97 113
Total Animals with Benign Neoplasms 43 41 46
Total Benign Neoplasms 78 75 80
Total Animals with Malignant Neoplasms 21 22 20
Total Malignant Neoplasms 22 22 33
Total Animals with Metastatic Neoplasms 2
Total Metastatic Neoplasm 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05048-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RHODAMINE 6G Date: 09/06/94
Route: DOSED FEED Time: 23:53:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.012% 0.025%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund 23 25 19
Dead 5 4 4
Survivors
Terminal Sacrifice 22 20 27
Dead 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large (50) (49) (50)
Intestine Small (50) (49) (50)
Ileum, Polyp Adenomatous 1 (2%)
Liver (50) (50) (50)
Hepatocellular Carcinoma 1 (2%) 1 (2%)
Neoplastic Nodule 3 (6%) 4 (8%)
Neoplastic Nodule, Multiple 1 (2%) 2 (4%)
Mesentery (2) (4) (4)
Sarcoma 1 (25%)
Pancreas (50) (49) (50)
Adenoma 1 (2%)
Acinus, Adenoma 2 (4%) 4 (8%)
Acinus, Adenoma, Multiple 1 (2%)
Salivary Glands (50) (49) (50)
Stomach (49) (50) (50)
Squamous Cell Papilloma 1 (2%)
Serosa, Sarcoma 1 (2%)
Tongue (2)
Squamous Cell Papilloma 1 (50%)
Tooth (1)
Neoplasm NOS 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05048-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RHODAMINE 6G Date: 09/06/94
Route: DOSED FEED Time: 23:53:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.012% 0.025%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (49) (50)
Cortex, Adenoma 1 (2%)
Medulla, Pheochromocytoma Malignant 9 (18%) 8 (16%) 5 (10%)
Medulla, Pheochromocytoma Malignant, Multiple 1 (2%)
Medulla, Pheochromocytoma Benign 14 (28%) 21 (43%) 19 (38%)
Medulla, Pheochromocytoma Benign, Multiple 4 (8%) 4 (8%) 4 (8%)
Islets, Pancreatic (50) (49) (50)
Adenoma 1 (2%) 2 (4%) 4 (8%)
Adenoma, Multiple 1 (2%)
Carcinoma 1 (2%) 1 (2%) 1 (2%)
Pituitary Gland (49) (49) (49)
Pars Distalis, Adenoma 9 (18%) 8 (16%) 12 (24%)
Thyroid Gland (50) (48) (50)
C-Cell, Adenoma 5 (10%) 6 (13%) 1 (2%)
C-Cell, Carcinoma 3 (6%) 1 (2%) 1 (2%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (49) (48) (43)
Adenoma 2 (4%) 3 (6%) 2 (5%)
Carcinoma 2 (4%) 4 (8%) 4 (9%)
Prostate (50) (49) (50)
Schwannoma Malignant 1 (2%)
Seminal Vesicle (4) (2)
Testes (49) (50) (50)
Seminoma Malignant, Poor 1 (2%)
Interstitial Cell, Adenoma 3 (6%) 7 (14%) 12 (24%)
Interstitial Cell, Adenoma, Multiple 43 (88%) 42 (84%) 32 (64%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (44) (46) (44)
Bone Marrow (50) (50) (50)
Lymph Node (50) (49) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Spleen (50) (50) (50)
Page 8
NTP Experiment-Test: 05048-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RHODAMINE 6G Date: 09/06/94
Route: DOSED FEED Time: 23:53:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.012% 0.025%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Hemangiosarcoma 1 (2%)
Sarcoma 1 (2%)
Capsule, Sarcoma 1 (2%)
Thymus (47) (47) (47)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (49) (46)
Fibroadenoma 5 (10%) 1 (2%) 4 (9%)
Fibroadenoma, Multiple 1 (2%)
Skin (50) (50) (50)
Basal Cell Adenoma 1 (2%) 2 (4%)
Keratoacanthoma 1 (2%) 2 (4%) 6 (12%)
Keratoacanthoma, Multiple 2 (4%)
Squamous Cell Papilloma 2 (4%) 3 (6%)
Trichoepithelioma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma 4 (8%) 6 (12%) 4 (8%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Liposarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Osteoma 1 (2%)
Osteosarcoma 1 (2%)
Vertebra, Chordoma 1 (2%)
Skeletal Muscle (2)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Astrocytoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Osteosarcoma, Multiple, Metastatic, Bone 1 (2%)
Nose (50) (50) (45)
Adenocarcinoma 1 (2%)
Page 9
NTP Experiment-Test: 05048-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RHODAMINE 6G Date: 09/06/94
Route: DOSED FEED Time: 23:53:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.012% 0.025%
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Adenocarcinoma, Moderately Well 1 (2%)
Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Renal Tubule, Adenoma 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (50) (49) (50)
Transitional Epithelium, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 27 (54%) 21 (42%) 19 (38%)
Mesothelioma Malignant 1 (2%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05048-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RHODAMINE 6G Date: 09/06/94
Route: DOSED FEED Time: 23:53:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.012% 0.025%
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 50 49
Total Primary Neoplasms 156 157 159
Total Animals with Benign Neoplasms 49 50 48
Total Benign Neoplasms 104 116 118
Total Animals with Malignant Neoplasms 39 33 30
Total Malignant Neoplasms 52 41 40
Total Animals with Metastatic Neoplasms 1 1
Total Metastatic Neoplasm 1 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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