TR 364 Rat Pathology Tables
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
Facility: Southern Research Institute
Chemical CAS #: 989-38-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 2| 3| 3| 4| 2| 2| 4| 4| 4| 3| 6| 4| 4| 4| 0| 7| 2| 3| 3|
| 1| 6| 6| 6| 6| 5| 9| 6| 6| 0| 6| 5| 0| 0| 0| 3| 5| 0| 0| 0| 2| 5| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cecum, Parasite Metazoan | 2 |
Colon, Parasite Metazoan | 2 |
Rectum, Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Basophilic Focus | X X X X X |
Basophilic Focus, Multiple | X X X X X X X X X X X |
Clear Cell Focus | X X |
Developmental Malformation | 2 2 |
Granuloma | 1 |
Granuloma, Multifocal | 1 1 1 1 1 1 1 1 |
Hematopoietic Cell Proliferation, | |
Multifocal | 1 |
Necrosis, Focal | |
Necrosis, Multifocal | 1 |
Vacuolization Cytoplasmic, Diffuse | 2 1 3|
Biliary Tract, Hyperplasia | 1 2 1 2 2 1 1 1 3 1 |
Centrilobular, Necrosis | 1 2 1 1 |
Hepatocyte, Hypertrophy | 1 2 1 |
__________________________________________________________________________|
Mesentery | + +|
Inflammation, Chronic, Focal | 2|
Fat, Necrosis, Focal | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 |
Inflammation, Focal, Subacute | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Subacute | |
Forestomach, Hyperkeratosis | 1 |
Forestomach, Hyperplasia | 2 |
Forestomach, Inflammation, Subacute | 3 4|
Forestomach, Perforation | X X|
Forestomach, Ulcer | 3 |
Glandular, Inflammation, Subacute | 3 |
Glandular, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Multifocal | 1 1 1 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 2| 3| 3| 4| 2| 2| 4| 4| 4| 3| 6| 4| 4| 4| 0| 7| 2| 3| 3|
| 1| 6| 6| 6| 6| 5| 9| 6| 6| 0| 6| 5| 0| 0| 0| 3| 5| 0| 0| 0| 2| 5| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cortex, Angiectasis, Focal | |
Cortex, Angiectasis, Multifocal | |
Cortex, Degeneration, Fatty, Focal | 2 2 |
Cortex, Degeneration, Fatty, | |
Multifocal | |
Cortex, Hyperplasia, Focal | 2 |
Cortex, Hypertrophy, Focal | |
Medulla, Hyperplasia, Focal | 1 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 4 |
Pars Distalis, Angiectasis | 2 3 2 3 2 3 2 2 2 3 3 2 2 2 3 3|
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 1 2 2 2 3 2 2 1 1 1 1 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 3 2 |
C-Cell, Hyperplasia, Multifocal | 2 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + M + + + + + M + M + M + + + + + + M + +|
Cyst | X X X |
Inflammation, Acute, Suppurative | 2 |
Inflammation, Focal, Subacute | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Inflammation, Acute, Suppurative | 2 2 |
Necrosis | 3 2 |
Cervix, Cyst | X X |
Mucosa, Cyst | X |
__________________________________________________________________________|
Vagina | |
Abscess | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 2| 3| 3| 4| 2| 2| 4| 4| 4| 3| 6| 4| 4| 4| 0| 7| 2| 3| 3|
| 1| 6| 6| 6| 6| 5| 9| 6| 6| 0| 6| 5| 0| 0| 0| 3| 5| 0| 0| 0| 2| 5| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 4 1 2 2 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Glandular | |
Duct, Cyst | X X X X X X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Acute, Focal, | |
Suppurative | |
Inflammation, Focal, Subacute | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X |
Degeneration, Multifocal | |
Hemorrhage, Multifocal | |
__________________________________________________________________________|
Spinal Cord | +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body, Multiple | |
Granuloma, Multifocal | |
Metaplasia, Multifocal, Osseous | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Nose | + + + + + M + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Acute, Suppurative | |
Inflammation, Granulomatous | |
Nasolacrimal Duct, Inflammation, | |
Acute, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 2| 3| 3| 4| 2| 2| 4| 4| 4| 3| 6| 4| 4| 4| 0| 7| 2| 3| 3|
| 1| 6| 6| 6| 6| 5| 9| 6| 6| 0| 6| 5| 0| 0| 0| 3| 5| 0| 0| 0| 2| 5| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | +|
__________________________________________________________________________|
Eye | |
Cataract | |
Hemorrhage | |
Retina, Degeneration | |
__________________________________________________________________________|
Lacrimal Gland | |
Ectopic Harderian | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 3 2 2 1 1 1 4 2 1 2 4 2 2 3 1 2 1 2 1 3|
Cortex, Cyst | |
Cortex, Inflammation, Acute, | |
Multifocal, Suppurative | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 0| 2| 4| 4| 4| 4| 6| 9| 3| 4| 6| 6| 4| 4| 4| 5| 9| 0| 4| 4| 0| 3| 4| 4| 4| |
| 0| 6| 0| 0| 0| 6| 9| 5| 4| 0| 1| 7| 0| 0| 0| 3| 5| 0| 0| 0| 7| 4| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cecum, Parasite Metazoan | 2 | 2 2.0|
Colon, Parasite Metazoan | 2 | 2 2.0|
Rectum, Parasite Metazoan | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | | 1 2.0|
Basophilic Focus | X X X X X X| 11 |
Basophilic Focus, Multiple | X X X X X X X | 18 |
Clear Cell Focus | | 2 |
Developmental Malformation | 2 1 | 4 1.8|
Granuloma | | 1 1.0|
Granuloma, Multifocal | 2 1 1 1 1 1 1 1 1 | 17 1.1|
Hematopoietic Cell Proliferation, | | |
Multifocal | | 1 1.0|
Necrosis, Focal | 1 | 1 1.0|
Necrosis, Multifocal | 1 | 2 1.0|
Vacuolization Cytoplasmic, Diffuse | 1 2 2 | 6 1.8|
Biliary Tract, Hyperplasia | 1 1 2 1 | 14 1.4|
Centrilobular, Necrosis | 1 1 1 | 7 1.1|
Hepatocyte, Hypertrophy | 1 1 | 5 1.2|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Inflammation, Chronic, Focal | | 1 2.0|
Fat, Necrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + M + M + + + +| 48 |
Atrophy | 4 2 1 2 1 | 7 2.1|
Inflammation, Focal, Subacute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Subacute | 2 | 1 2.0|
Forestomach, Hyperkeratosis | 1 1 | 3 1.0|
Forestomach, Hyperplasia | 2 2 | 3 2.0|
Forestomach, Inflammation, Subacute | 2 3 | 4 3.0|
Forestomach, Perforation | | 2 |
Forestomach, Ulcer | 4 | 2 3.5|
Glandular, Inflammation, Subacute | 2 | 2 2.5|
Glandular, Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 0| 2| 4| 4| 4| 4| 6| 9| 3| 4| 6| 6| 4| 4| 4| 5| 9| 0| 4| 4| 0| 3| 4| 4| 4| |
| 0| 6| 0| 0| 0| 6| 9| 5| 4| 0| 1| 7| 0| 0| 0| 3| 5| 0| 0| 0| 7| 4| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Multifocal | 2 1 2 2 1 1 2 1 1 1 2 | 16 1.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cortex, Angiectasis, Focal | 3 | 1 3.0|
Cortex, Angiectasis, Multifocal | 2 | 1 2.0|
Cortex, Degeneration, Fatty, Focal | 2 2 2 | 5 2.0|
Cortex, Degeneration, Fatty, | | |
Multifocal | 2 2 | 2 2.0|
Cortex, Hyperplasia, Focal | | 1 2.0|
Cortex, Hypertrophy, Focal | 2 | 1 2.0|
Medulla, Hyperplasia, Focal | 2 | 4 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + M + M + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + M M + + + + + + + + + + + + +| 46 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Hemorrhage, Focal | | 1 4.0|
Pars Distalis, Angiectasis | 3 4 3 2 2 3 2 1 1 2 2 3 2 3 3 1 3 3| 34 2.4|
Pars Distalis, Cyst | X X X X X X X | 11 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 | 7 2.0|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 2 1 1 2 1 1 2 1 1 1 1 2| 25 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Focal | 2| 3 2.3|
C-Cell, Hyperplasia, Multifocal | | 1 2.0|
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M M + + + + + + + + + + + + + + + + + +| 42 |
Cyst | X X | 5 |
Inflammation, Acute, Suppurative | | 1 2.0|
Inflammation, Focal, Subacute | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 0| 2| 4| 4| 4| 4| 6| 9| 3| 4| 6| 6| 4| 4| 4| 5| 9| 0| 4| 4| 0| 3| 4| 4| 4| |
| 0| 6| 0| 0| 0| 6| 9| 5| 4| 0| 1| 7| 0| 0| 0| 3| 5| 0| 0| 0| 7| 4| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Hemorrhage, Focal | 2 | 1 2.0|
Inflammation, Acute, Suppurative | | 2 2.0|
Necrosis | | 2 2.5|
Cervix, Cyst | | 2 |
Mucosa, Cyst | | 1 |
__________________________________________________________________________|____________|
Vagina | + | 1 |
Abscess | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 3 1.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mandibular, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Fibrosis, Focal | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 3 3 | 7 2.7|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + + + + + + + M M M M + M + + +| 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Hyperplasia, Glandular | 3 | 1 3.0|
Duct, Cyst | X X X X X X X X X X X X X X X X X X X X X X X X| 47 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 3.0|
Inflammation, Acute, Focal, | | |
Suppurative | 2 | 1 2.0|
Inflammation, Focal, Subacute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X | 4 |
Degeneration, Multifocal | 2 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 0| 2| 4| 4| 4| 4| 6| 9| 3| 4| 6| 6| 4| 4| 4| 5| 9| 0| 4| 4| 0| 3| 4| 4| 4| |
| 0| 6| 0| 0| 0| 6| 9| 5| 4| 0| 1| 7| 0| 0| 0| 3| 5| 0| 0| 0| 7| 4| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Hemorrhage, Multifocal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body, Multiple | 2 | 1 2.0|
Granuloma, Multifocal | 3 | 1 3.0|
Metaplasia, Multifocal, Osseous | 1 | 1 1.0|
Pigmentation, Hemosiderin | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | 3 | 1 3.0|
Inflammation, Acute, Suppurative | 1 2 | 2 1.5|
Inflammation, Granulomatous | 3 | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Acute, Suppurative | 1 2 | 3 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + + | 4 |
__________________________________________________________________________|____________|
Eye | + + | 2 |
Cataract | 3 | 1 3.0|
Hemorrhage | 2 | 1 2.0|
Retina, Degeneration | 3 1 | 2 2.0|
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
Ectopic Harderian | 3 | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 1 3 1 3 1 2 2 2 1 3 2 2 2 2 2 2 1 3 2| 39 2.0|
Cortex, Cyst | X | 1 |
Cortex, Inflammation, Acute, | | |
Multifocal, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 5| 5| 7| 7|
DAY ON TEST | 2| 9| 3| 3| 3| 3| 3| 3| 3| 3| 6| 2| 3| 3| 3| 2| 2| 3| 3| 3| 0| 3| 7| 3| 3|
| 9| 4| 4| 4| 4| 1| 4| 4| 4| 4| 2| 7| 4| 4| 4| 0| 3| 4| 4| 4| 5| 1| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.025% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M + + + + + M + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | X X X X |
Basophilic Focus, Multiple | X X X X X X X X X X X|
Congestion, Diffuse | |
Developmental Malformation | 2 2 2 |
Granuloma | 2 |
Granuloma, Multifocal | 1 1 1 2 1 1 1 |
Hematopoietic Cell Proliferation, | |
Multifocal | 3 1 |
Hemorrhage, Multifocal | 2 |
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | 4 |
Necrosis, Focal | |
Necrosis, Multifocal | 2 |
Pigmentation, Hemosiderin, Multifocal| 1 |
Thrombosis, Multiple | X |
Vacuolization Cytoplasmic, Diffuse | 4 2 2 3 |
Vacuolization Cytoplasmic, Focal | 3 |
Biliary Tract, Hyperplasia | 2 1 2 1 1 2 2|
Centrilobular, Necrosis | 1 1 1|
Hepatocyte, Hypertrophy | 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Focal | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 2 1 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Multifocal, Subacute | 2 |
Duct, Cyst | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Edema | 3 2 4 |
Forestomach, Hyperkeratosis | 2 |
Forestomach, Hyperplasia | 2 2 |
Forestomach, Ulcer | 2 2 3 3 |
Forestomach, Ulcer, Multiple | 4 |
Glandular, Erosion | 2 |
Glandular, Ulcer | |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + |
Inflammation, Acute, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 5| 5| 7| 7|
DAY ON TEST | 2| 9| 3| 3| 3| 3| 3| 3| 3| 3| 6| 2| 3| 3| 3| 2| 2| 3| 3| 3| 0| 3| 7| 3| 3|
| 9| 4| 4| 4| 4| 1| 4| 4| 4| 4| 2| 7| 4| 4| 4| 0| 3| 4| 4| 4| 5| 1| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.025% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Multifocal | 2 2 1 1 2 1 1 1 1 |
Atrium, Mineralization, Focal | |
Atrium, Pigmentation, Hemosiderin | |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cortex, Angiectasis, Multifocal | |
Cortex, Congestion, Diffuse | |
Cortex, Degeneration, Fatty, Focal | 2 2 2 1 |
Cortex, Degeneration, Fatty, | |
Multifocal | 2 2 3 |
Cortex, Hyperplasia, Focal | 1 |
Medulla, Hyperplasia, Focal | 3 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 3 3 2 2 3 3 3 3 3 3 2 2 2 3 |
Pars Distalis, Cyst | X X X X X|
Pars Distalis, Hyperplasia, Focal | 1 2 2 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 1 1 1 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 3 |
C-Cell, Hyperplasia, Multifocal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + M + + + M + + + M + + M M + + +|
Cyst | X X |
Inflammation, Acute, Suppurative | 3 |
Inflammation, Focal, Subacute | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 3|
Hydrometra | 2 |
Cervix, Abscess | 4 4 2 |
Cervix, Cyst | X |
Endometrium, Hyperplasia, Cystic | 2 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 5| 5| 7| 7|
DAY ON TEST | 2| 9| 3| 3| 3| 3| 3| 3| 3| 3| 6| 2| 3| 3| 3| 2| 2| 3| 3| 3| 0| 3| 7| 3| 3|
| 9| 4| 4| 4| 4| 1| 4| 4| 4| 4| 2| 7| 4| 4| 4| 0| 3| 4| 4| 4| 5| 1| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.025% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Mucosa, Cyst | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia | |
Mandibular, Ectasia | 2 |
Mesenteric, Congestion | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 2 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Glandular | 3 |
Duct, Cyst | X X X X X X X X X X X X X X X X X X X X X X X X|
Duct, Cyst, Multiple | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Inflammation, Acute, Focal, | |
Suppurative | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Necrosis, Multifocal | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Macrophage | |
Pigmentation, Hemosiderin | |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + M + + + +|
Fungus | 2 |
Inflammation, Acute, Suppurative | 1 1 |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 5| 5| 7| 7|
DAY ON TEST | 2| 9| 3| 3| 3| 3| 3| 3| 3| 3| 6| 2| 3| 3| 3| 2| 2| 3| 3| 3| 0| 3| 7| 3| 3|
| 9| 4| 4| 4| 4| 1| 4| 4| 4| 4| 2| 7| 4| 4| 4| 0| 3| 4| 4| 4| 5| 1| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.025% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Nasolacrimal Duct, Foreign Body | |
Nasolacrimal Duct, Inflammation, | |
Acute, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + + + + + +|
Inflammation, Acute, Suppurative | 2|
__________________________________________________________________________|
Eye | + + + + +|
Cataract | 4 2|
Cornea, Inflammation, Chronic | 3 3 |
Retina, Degeneration | 2 4 2 2|
__________________________________________________________________________|
Lacrimal Gland | |
Ectopic Harderian | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 4 1 3 1 2 4 2 1 1 3 2 1 3 1 1 2 2 1|
Medulla, Mineralization, Focal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| |
DAY ON TEST | 9| 2| 3| 3| 3| 4| 6| 3| 3| 3| 6| 2| 3| 3| 3| 3| 2| 3| 3| 3| 1| 5| 3| 3| 3| |
| 7| 9| 4| 4| 4| 3| 0| 4| 4| 4| 1| 8| 4| 4| 4| 5| 9| 5| 5| 5| 5| 3| 4| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.025% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M + M + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 2 | 1 2.0|
Basophilic Focus | X | 5 |
Basophilic Focus, Multiple | X X X X X X X X X X X X X X X X X| 28 |
Congestion, Diffuse | 1 | 1 1.0|
Developmental Malformation | | 3 2.0|
Granuloma | | 1 2.0|
Granuloma, Multifocal | 1 1 1 1 1 1 1 1 1 | 16 1.1|
Hematopoietic Cell Proliferation, | | |
Multifocal | | 2 2.0|
Hemorrhage, Multifocal | | 1 2.0|
Hepatodiaphragmatic Nodule | X X | 3 |
Mixed Cell Focus | | 1 4.0|
Necrosis, Focal | 1 | 1 1.0|
Necrosis, Multifocal | 1| 2 1.5|
Pigmentation, Hemosiderin, Multifocal| | 1 1.0|
Thrombosis, Multiple | | 1 |
Vacuolization Cytoplasmic, Diffuse | 3 1 2 | 7 2.4|
Vacuolization Cytoplasmic, Focal | | 1 3.0|
Biliary Tract, Hyperplasia | 3 1 1 1 1 2 | 13 1.5|
Centrilobular, Necrosis | 1 1 1 1 | 7 1.0|
Hepatocyte, Hypertrophy | 1 2 2 | 4 1.8|
__________________________________________________________________________|____________|
Mesentery | + + + + + + +| 9 |
Fat, Necrosis, Focal | 2 3 3 X 3 3 2| 9 2.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 1 | 8 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
Inflammation, Multifocal, Subacute | | 1 2.0|
Duct, Cyst | X | 2 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Forestomach, Edema | 2 | 4 2.8|
Forestomach, Hyperkeratosis | 2 | 2 2.0|
Forestomach, Hyperplasia | 2 | 3 2.0|
Forestomach, Ulcer | | 4 2.5|
Forestomach, Ulcer, Multiple | | 1 4.0|
Glandular, Erosion | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| |
DAY ON TEST | 9| 2| 3| 3| 3| 4| 6| 3| 3| 3| 6| 2| 3| 3| 3| 3| 2| 3| 3| 3| 1| 5| 3| 3| 3| |
| 7| 9| 4| 4| 4| 3| 0| 4| 4| 4| 1| 8| 4| 4| 4| 5| 9| 5| 5| 5| 5| 3| 4| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.025% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Glandular, Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation, Acute, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Multifocal | 2 1 2 2 1 1 1 1 2 1 2 1 2| 22 1.4|
Atrium, Mineralization, Focal | 2 | 1 2.0|
Atrium, Pigmentation, Hemosiderin | 1 | 1 1.0|
Atrium, Thrombosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cortex, Angiectasis, Multifocal | 3 | 1 3.0|
Cortex, Congestion, Diffuse | 2 | 1 2.0|
Cortex, Degeneration, Fatty, Focal | 2 2 2 | 7 1.9|
Cortex, Degeneration, Fatty, | | |
Multifocal | 3 2 | 5 2.4|
Cortex, Hyperplasia, Focal | 2 | 2 1.5|
Medulla, Hyperplasia, Focal | 1 2 1 1 1 | 8 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + M| 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 3 3 3 2 2 2 2 2 1 3 1 1 3 2| 30 2.4|
Pars Distalis, Cyst | X X X | 8 |
Pars Distalis, Hyperplasia, Focal | 1 1 2 2 2 | 9 1.7|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 1 2 1 1 1 1 1 1 | 15 1.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Focal | 2 2 1 3 | 5 2.2|
C-Cell, Hyperplasia, Multifocal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + M + M + + + + M + + + + + + + + + M + + M +| 39 |
Cyst | X X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| |
DAY ON TEST | 9| 2| 3| 3| 3| 4| 6| 3| 3| 3| 6| 2| 3| 3| 3| 3| 2| 3| 3| 3| 1| 5| 3| 3| 3| |
| 7| 9| 4| 4| 4| 3| 0| 4| 4| 4| 1| 8| 4| 4| 4| 5| 9| 5| 5| 5| 5| 3| 4| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.025% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Acute, Suppurative | 3 2 | 3 2.7|
Inflammation, Focal, Subacute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X X | 6 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Focal | | 1 3.0|
Hydrometra | | 1 2.0|
Cervix, Abscess | 3 3 | 5 3.2|
Cervix, Cyst | X X | 3 |
Endometrium, Hyperplasia, Cystic | | 1 2.0|
Mucosa, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Hyperplasia | 2 | 1 2.0|
Mandibular, Ectasia | | 1 2.0|
Mesenteric, Congestion | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 1 4 3| 5 2.2|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Glandular | | 1 3.0|
Duct, Cyst | X X X X X X X X X X X X X X X X X X| 42 |
Duct, Cyst, Multiple | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 1 |
Inflammation, Acute, Focal, | | |
Suppurative | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| |
DAY ON TEST | 9| 2| 3| 3| 3| 4| 6| 3| 3| 3| 6| 2| 3| 3| 3| 3| 2| 3| 3| 3| 1| 5| 3| 3| 3| |
| 7| 9| 4| 4| 4| 3| 0| 4| 4| 4| 1| 8| 4| 4| 4| 5| 9| 5| 5| 5| 5| 3| 4| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.025% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X | 3 |
Necrosis, Multifocal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Spinal Cord | + + + | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Macrophage | 2 | 1 2.0|
Pigmentation, Hemosiderin | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + M + + + + + + + + + M + + + +| 47 |
Fungus | | 1 2.0|
Inflammation, Acute, Suppurative | | 2 1.0|
Nasolacrimal Duct, Foreign Body | 1 | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Acute, Suppurative | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + + + + | 12 |
Inflammation, Acute, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Eye | + | 6 |
Cataract | 2 | 3 2.7|
Cornea, Inflammation, Chronic | | 2 3.0|
Retina, Degeneration | 3 | 5 2.6|
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
Ectopic Harderian | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 2 1 3 1 2 1 2 1 2 1 3 1 1 1 2 2 2 3| 36 1.8|
Medulla, Mineralization, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 7| 3| 3| 3| 6| 7| 0| 2| 3| 9| 3| 3| 3| 3|
| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 5| 5| 5| 8| 5| 0| 5| 5| 7| 5| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.012% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + A + + + + + + + + + + + + + +|
Colon, Parasite Metazoan | |
Rectum, Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Basophilic Focus | X X X X|
Basophilic Focus, Multiple | X X X X X X X X X X X X X |
Developmental Malformation | 2 2 2 |
Granuloma | 1 |
Granuloma, Multifocal | 1 1 2 2 3 2 1 2 |
Hepatodiaphragmatic Nodule | X |
Necrosis, Focal | |
Vacuolization Cytoplasmic, Diffuse | 3 1 2 |
Vacuolization Cytoplasmic, Focal | 2 |
Biliary Tract, Hyperplasia | 2 2 1 2 1 1 1 1 1 1 1 1|
Centrilobular, Necrosis | 1 1 |
Hepatocyte, Hypertrophy | 1 1 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Focal | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + A + + + + + + + + + + + + + +|
Atrophy | 2 1 2 1 2 |
Artery, Inflammation, Subacute | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + M + + + + + + + + + + + + + +|
Duct, Cyst | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Edema | |
Forestomach, Hyperkeratosis | 2 |
Forestomach, Hyperplasia | 2 |
Forestomach, Inflammation, Subacute | 2 |
Forestomach, Ulcer | 3 2 |
Forestomach, Ulcer, Multiple | |
Glandular, Edema | |
Glandular, Erosion | |
Glandular, Inflammation, Subacute | |
Glandular, Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Multifocal | 1 1 2 2 1 2 2 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 7| 3| 3| 3| 6| 7| 0| 2| 3| 9| 3| 3| 3| 3|
| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 5| 5| 5| 8| 5| 0| 5| 5| 7| 5| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.012% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Accessory Adrenal Cortical Nodule | |
Cortex, Angiectasis, Focal | 2 |
Cortex, Congestion, Diffuse | 2 |
Cortex, Degeneration, Fatty, Focal | 1 2 2 1 1 |
Cortex, Degeneration, Fatty, | |
Multifocal | 2 2 2 |
Cortex, Hyperplasia, Focal | 2 |
Cortex, Necrosis, Focal | |
Medulla, Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + A + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Pars Distalis, Angiectasis | 1 3 3 3 3 2 3 4 4 1 4 2 3 3|
Pars Distalis, Cyst | X X X X X X X |
Pars Distalis, Hyperplasia, Focal | 1 1 3 1 2 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 1 1 1 1 1 2 1 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | |
C-Cell, Hyperplasia, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + M + + + + + M M + + + + + + + + +|
Cyst | |
Inflammation, Acute, Suppurative | 2 2 |
Inflammation, Focal, Subacute | 2 |
__________________________________________________________________________|
Ovary | + + + M + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 |
Cervix, Abscess | 3 3 3 3 |
Cervix, Cyst | X X X X |
Cervix, Necrosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + A + + + + + + + + + + + + + +|
Deep Cervical, Congestion | 2 |
Inguinal, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 7| 3| 3| 3| 6| 7| 0| 2| 3| 9| 3| 3| 3| 3|
| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 5| 5| 5| 8| 5| 0| 5| 5| 7| 5| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.012% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mandibular, Ectasia | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + A + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 1 |
Hyperplasia, Focal, Lymphoid | |
Necrosis, Focal | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Glandular | 2 3|
Duct, Cyst | X X X X X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 |
Hyperkeratosis, Focal | |
Hyperplasia, Focal | |
Inflammation, Acute, Focal, | |
Suppurative | 3 |
Inflammation, Granulomatous, | |
Multifocal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis, Focal | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X |
Degeneration, Multifocal | 2 2 |
Hemorrhage, Multifocal | |
Mineralization, Focal | 2 |
Cerebellum, Mineralization, | |
Multifocal | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atelectasis, Multifocal | |
Congestion | 3 |
Hemorrhage, Multifocal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 3 |
Inflammation, Acute, Suppurative | 1 2 |
Nasolacrimal Duct, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 7| 3| 3| 3| 6| 7| 0| 2| 3| 9| 3| 3| 3| 3|
| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 5| 5| 5| 8| 5| 0| 5| 5| 7| 5| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.012% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Acute, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + + + + + + + |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + +|
Cataract | 2 4 3 4 3 3 4 4 4 4 3 3 3 2 4 1 4 4 3 2|
Retina, Degeneration | 3 4 3 4 3 3 3 4 4 4 3 3 3 2 3 3 4 3 3 3|
__________________________________________________________________________|
Lacrimal Gland | + + + |
Ectopic Harderian | 2 2 X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 1 2 1 2 2 2 1 3 2 2 3 4 1 2 1 1 2|
Right, Hydronephrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 0| 3| 2| 3| 3| 2| 2| 3| 3| 3| 6| 9| 3| 3| 3| 6| 2| 3| 3| 3| 7| 5| 2| 3| 3| |
| 3| 8| 8| 6| 6| 5| 9| 6| 6| 6| 0| 6| 6| 6| 6| 4| 2| 6| 6| 6| 2| 7| 8| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.012% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Colon, Parasite Metazoan | 2 2 | 2 2.0|
Rectum, Parasite Metazoan | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Angiectasis, Focal | | 1 2.0|
Basophilic Focus | X X X X | 8 |
Basophilic Focus, Multiple | X X X X X X X X X| 22 |
Developmental Malformation | 2 | 4 2.0|
Granuloma | | 1 1.0|
Granuloma, Multifocal | 1 2 1 1 2 2 1 2 1 1 | 18 1.6|
Hepatodiaphragmatic Nodule | X | 2 |
Necrosis, Focal | 1 | 1 1.0|
Vacuolization Cytoplasmic, Diffuse | 3 3 2 1 3 | 8 2.3|
Vacuolization Cytoplasmic, Focal | 1 | 2 1.5|
Biliary Tract, Hyperplasia | 3 2 1 1 2 2 2 | 19 1.5|
Centrilobular, Necrosis | 1 1 1 2 | 6 1.2|
Hepatocyte, Hypertrophy | 2 2 1 1 | 6 1.3|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fat, Necrosis, Focal | 2 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 1 1 1 | 9 1.6|
Artery, Inflammation, Subacute | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Forestomach, Edema | 2 | 1 2.0|
Forestomach, Hyperkeratosis | 1 2 2 2 | 5 1.8|
Forestomach, Hyperplasia | 2 2 2 2 | 5 2.0|
Forestomach, Inflammation, Subacute | 2 2 2 | 4 2.0|
Forestomach, Ulcer | 4 3 | 4 3.0|
Forestomach, Ulcer, Multiple | 3 | 1 3.0|
Glandular, Edema | 2 | 1 2.0|
Glandular, Erosion | 2 | 1 2.0|
Glandular, Inflammation, Subacute | 2 | 1 2.0|
Glandular, Ulcer | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 0| 3| 2| 3| 3| 2| 2| 3| 3| 3| 6| 9| 3| 3| 3| 6| 2| 3| 3| 3| 7| 5| 2| 3| 3| |
| 3| 8| 8| 6| 6| 5| 9| 6| 6| 6| 0| 6| 6| 6| 6| 4| 2| 6| 6| 6| 2| 7| 8| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.012% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Multifocal | 2 1 2 1 1 1 1 2 2 2 2 2 2| 26 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X | 1 |
Cortex, Angiectasis, Focal | | 1 2.0|
Cortex, Congestion, Diffuse | | 1 2.0|
Cortex, Degeneration, Fatty, Focal | 2 2 1 3 2 2 3 2 | 13 1.8|
Cortex, Degeneration, Fatty, | | |
Multifocal | 2 | 4 2.0|
Cortex, Hyperplasia, Focal | 2| 2 2.0|
Cortex, Necrosis, Focal | 3 | 1 3.0|
Medulla, Hyperplasia, Focal | 1 2 2 1 | 6 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage, Focal | 2 | 1 2.0|
Pars Distalis, Angiectasis | 4 2 4 3 3 2 4 3 2 1 3 3 2 3 4 4| 30 2.9|
Pars Distalis, Cyst | X X X X X X X X X X X | 18 |
Pars Distalis, Hyperplasia, Focal | 2 | 7 1.7|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 2 1 1 2 1 1 1 2 2 | 17 1.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Focal | 2 | 1 2.0|
C-Cell, Hyperplasia, Multifocal | 1| 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M M + M M + M + + + + M M + + + + + + + + + +| 40 |
Cyst | X X | 2 |
Inflammation, Acute, Suppurative | 3 2 | 4 2.3|
Inflammation, Focal, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | X X X | 5 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 0| 3| 2| 3| 3| 2| 2| 3| 3| 3| 6| 9| 3| 3| 3| 6| 2| 3| 3| 3| 7| 5| 2| 3| 3| |
| 3| 8| 8| 6| 6| 5| 9| 6| 6| 6| 0| 6| 6| 6| 6| 4| 2| 6| 6| 6| 2| 7| 8| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.012% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cervix, Abscess | 4 | 5 3.2|
Cervix, Cyst | X | 5 |
Cervix, Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Deep Cervical, Congestion | | 1 2.0|
Inguinal, Hyperplasia | 2 | 1 2.0|
Mandibular, Ectasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 3 2 | 5 1.6|
Hyperplasia, Focal, Lymphoid | 4 | 1 4.0|
Necrosis, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + M + + + + + + + + + + + M + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Glandular | 3 | 3 2.7|
Duct, Cyst | X X X X X X X X X X X X X X X X X X X X X X| 44 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 2 | 3 2.0|
Hyperkeratosis, Focal | 4 | 1 4.0|
Hyperplasia, Focal | 2 | 1 2.0|
Inflammation, Acute, Focal, | | |
Suppurative | 3 | 2 3.0|
Inflammation, Granulomatous, | | |
Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Hyperostosis, Focal | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 | 4 3.0|
Degeneration, Multifocal | 2 2 2 2 3 | 7 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 0| 3| 2| 3| 3| 2| 2| 3| 3| 3| 6| 9| 3| 3| 3| 6| 2| 3| 3| 3| 7| 5| 2| 3| 3| |
| 3| 8| 8| 6| 6| 5| 9| 6| 6| 6| 0| 6| 6| 6| 6| 4| 2| 6| 6| 6| 2| 7| 8| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.012% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Hemorrhage, Multifocal | 2 2 | 2 2.0|
Mineralization, Focal | | 1 2.0|
Cerebellum, Mineralization, | | |
Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atelectasis, Multifocal | 2 | 1 2.0|
Congestion | | 1 3.0|
Hemorrhage, Multifocal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fungus | 4 | 2 3.5|
Inflammation, Acute, Suppurative | 2 | 3 1.7|
Nasolacrimal Duct, Inflammation, | | |
Acute, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + + | 11 |
__________________________________________________________________________|____________|
Eye | + | 21 |
Cataract | 4 | 21 3.2|
Retina, Degeneration | 3 | 21 3.2|
__________________________________________________________________________|____________|
Lacrimal Gland | | 3 |
Ectopic Harderian | | 3 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 1 3 1 1 1 1 2 3 1 1 3 2 1 3 2 4 2 2 2| 37 1.9|
Right, Hydronephrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 6| 9| 2| 3| 3| 1| 2| 9| 3| 3| 3| 3| 3| 3| 3| 7| 0| 9| 9| 3| 0| 2| 1| 3| 3|
| 8| 9| 4| 4| 6| 8| 0| 5| 4| 6| 4| 6| 6| 6| 6| 6| 3| 4| 5| 6| 0| 1| 3| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Colon, Cyst | |
Colon, Diverticulum | |
Colon, Edema | |
Colon, Parasite Metazoan | 2 2 2 |
Rectum, Mineralization | 2 |
Rectum, Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 2 1 |
Angiectasis, Multifocal | 2 2 1 |
Basophilic Focus | X |
Basophilic Focus, Multiple | X X |
Developmental Malformation | 2 2 2 2 |
Fibrosis, Focal | |
Granuloma, Multifocal | 2 |
Hemorrhage, Focal | |
Necrosis, Multifocal | |
Pigmentation, Focal, Hemosiderin | |
Vacuolization Cytoplasmic, Diffuse | 3 |
Vacuolization Cytoplasmic, Focal | |
Vacuolization Cytoplasmic, Multifocal| |
Biliary Tract, Hyperplasia | 1 2 3 2 2 1 2 1 4 2 3 2 2 3 2 3 2|
Centrilobular, Necrosis | 2 1 1 1 |
Hepatocyte, Hypertrophy | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Focal | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 2 2 2|
Artery, Inflammation, Subacute | 3 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + M + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Subacute | |
Forestomach, Foreign Body | 2 |
Forestomach, Hyperkeratosis | 2 |
Forestomach, Hyperplasia | 2 |
Forestomach, Inflammation, Focal, | |
Granulomatous | 2 |
Forestomach, Inflammation, Subacute | 2 |
Forestomach, Mineralization | 1 |
Forestomach, Ulcer | 2 2 |
Glandular, Mineralization | 2 |
Glandular, Ulcer | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 6| 9| 2| 3| 3| 1| 2| 9| 3| 3| 3| 3| 3| 3| 3| 7| 0| 9| 9| 3| 0| 2| 1| 3| 3|
| 8| 9| 4| 4| 6| 8| 0| 5| 4| 6| 4| 6| 6| 6| 6| 6| 3| 4| 5| 6| 0| 1| 3| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Glandular, Ulcer, Multiple | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Mineralization | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Multifocal | 2 2 1 2 1 2 2 2 2 2 2 2 2 2 2 2|
Mineralization | 2 |
Atrium, Thrombosis | X 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cortex, Angiectasis, Focal | 2 |
Cortex, Congestion | |
Cortex, Degeneration, Fatty, Focal | 1 |
Cortex, Degeneration, Fatty, | |
Multifocal | 2 2 |
Cortex, Hyperplasia, Multifocal | |
Cortex, Hyperplasia, Multifocal, | |
Multifocal | |
Medulla, Hyperplasia, Focal | 2 2 2 |
Medulla, Hyperplasia, Multifocal | 1 |
Medulla, Necrosis, Multifocal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia | 2 1 1 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 4 2 4 |
Pars Distalis, Cyst | |
Pars Distalis, Hemorrhage, Focal | |
Pars Distalis, Hyperplasia, Focal | 2 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 1 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia, Focal | 2 |
C-Cell, Hyperplasia, Multifocal | 2 |
Follicle, Cyst | |
Follicle, Hyperplasia, Cystic, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 6| 9| 2| 3| 3| 1| 2| 9| 3| 3| 3| 3| 3| 3| 3| 7| 0| 9| 9| 3| 0| 2| 1| 3| 3|
| 8| 9| 4| 4| 6| 8| 0| 5| 4| 6| 4| 6| 6| 6| 6| 6| 3| 4| 5| 6| 0| 1| 3| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Suppurative | 3 3 2 |
Inflammation, Subacute | 2 |
Duct, Cyst | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Acute, Suppurative | 1 2 3 2 2 2 2 2 1|
Inflammation, Chronic | 1 2 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Inflammation, Acute, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Ectasia | |
Inguinal, Hyperplasia | |
Mandibular, Ectasia | 2 3 |
Mediastinal, Hyperplasia | |
Mesenteric, Angiectasis | 2 |
Mesenteric, Congestion | 2 |
Mesenteric, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Developmental Malformation | |
Fibrosis | 2 3 3 2 3 |
Hematopoietic Cell Proliferation | |
Capsule, Fibrosis, Focal | |
__________________________________________________________________________|
Thymus | + + M + + + + + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | X |
Cyst Epithelial Inclusion | |
Hyperkeratosis, Focal | |
Hyperplasia, Focal | |
Inflammation, Acute, Focal, | |
Suppurative | 2 |
Inflammation, Focal, Granulomatous | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 6| 9| 2| 3| 3| 1| 2| 9| 3| 3| 3| 3| 3| 3| 3| 7| 0| 9| 9| 3| 0| 2| 1| 3| 3|
| 8| 9| 4| 4| 6| 8| 0| 5| 4| 6| 4| 6| 6| 6| 6| 6| 3| 4| 5| 6| 0| 1| 3| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 1 X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Degeneration, Multifocal | 1 |
Hemorrhage, Multifocal | 2 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Cyst | X |
Hemorrhage, Multifocal | 2 1 |
Mineralization | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 2 |
Fungus | 3 3 3 3 2 3 3 |
Inflammation, Acute, Suppurative | 2 2 2 2 2 2 3 4 2 |
Nasolacrimal Duct, Inflammation, | |
Acute, Suppurative | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + + + + |
__________________________________________________________________________|
Eye | + + + + |
Cataract | 2 |
Synechia | 2 |
Cornea, Inflammation, Chronic | 3 |
Retina, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 4 3 4 3 4 2 4 3 4 3 3 4 3 1 3 2 2 2 3 3 2 2 4 2|
Cortex, Cyst | X X X |
Cortex, Mineralization | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 6| 9| 2| 3| 3| 7| 0| 9| 3| 3| 8| 6| 9| 3| 3| 6| 9| 9| 3| 3| 7| 9| 2| 3| 3| |
| 2| 4| 4| 6| 6| 4| 3| 4| 6| 6| 5| 7| 8| 6| 6| 1| 5| 7| 4| 6| 2| 4| 4| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Colon, Cyst | X| 1 |
Colon, Diverticulum | 2 | 1 2.0|
Colon, Edema | 2 | 1 2.0|
Colon, Parasite Metazoan | 2 2 2 | 6 2.0|
Rectum, Mineralization | | 1 2.0|
Rectum, Parasite Metazoan | 2| 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 1 2 2 1 | 7 1.6|
Angiectasis, Multifocal | 2 2 2 3 2 | 8 2.0|
Basophilic Focus | X | 2 |
Basophilic Focus, Multiple | X | 3 |
Developmental Malformation | 2| 5 2.0|
Fibrosis, Focal | 4 | 1 4.0|
Granuloma, Multifocal | 2 | 2 2.0|
Hemorrhage, Focal | 2 | 1 2.0|
Necrosis, Multifocal | 3 | 1 3.0|
Pigmentation, Focal, Hemosiderin | 3 | 1 3.0|
Vacuolization Cytoplasmic, Diffuse | 2 3 | 3 2.7|
Vacuolization Cytoplasmic, Focal | 2| 1 2.0|
Vacuolization Cytoplasmic, Multifocal| 1 | 1 1.0|
Biliary Tract, Hyperplasia | 4 2 2 3 2 2 4 1 3 2 3 2 3 2 2| 32 2.3|
Centrilobular, Necrosis | 1 2 1 1 1 1 1 1 | 12 1.2|
Hepatocyte, Hypertrophy | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fat, Necrosis, Focal | 3 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 3 2 2 | 9 1.8|
Artery, Inflammation, Subacute | 2 | 3 2.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Artery, Inflammation, Subacute | 2 | 1 2.0|
Forestomach, Foreign Body | | 1 2.0|
Forestomach, Hyperkeratosis | | 1 2.0|
Forestomach, Hyperplasia | | 1 2.0|
Forestomach, Inflammation, Focal, | | |
Granulomatous | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 6| 9| 2| 3| 3| 7| 0| 9| 3| 3| 8| 6| 9| 3| 3| 6| 9| 9| 3| 3| 7| 9| 2| 3| 3| |
| 2| 4| 4| 6| 6| 4| 3| 4| 6| 6| 5| 7| 8| 6| 6| 1| 5| 7| 4| 6| 2| 4| 4| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Forestomach, Inflammation, Subacute | 2 | 2 2.0|
Forestomach, Mineralization | | 1 1.0|
Forestomach, Ulcer | 3 | 3 2.3|
Glandular, Mineralization | | 1 2.0|
Glandular, Ulcer | 2 | 1 2.0|
Glandular, Ulcer, Multiple | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Multifocal | 1 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 1 2 1| 35 1.8|
Mineralization | | 1 2.0|
Atrium, Thrombosis | 3 | 3 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cortex, Angiectasis, Focal | 2 | 2 2.0|
Cortex, Congestion | 2 | 1 2.0|
Cortex, Degeneration, Fatty, Focal | | 1 1.0|
Cortex, Degeneration, Fatty, | | |
Multifocal | | 2 2.0|
Cortex, Hyperplasia, Multifocal | 2 | 1 2.0|
Cortex, Hyperplasia, Multifocal, | | |
Multifocal | 2 | 1 2.0|
Medulla, Hyperplasia, Focal | 2 1 2 | 6 1.8|
Medulla, Hyperplasia, Multifocal | | 1 1.0|
Medulla, Necrosis, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + + M + + + + + + + + + + + +| 47 |
Hyperplasia | | 4 1.3|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 3 | 6 2.8|
Pars Distalis, Cyst | X X | 2 |
Pars Distalis, Hemorrhage, Focal | 1 | 1 1.0|
Pars Distalis, Hyperplasia, Focal | | 2 2.0|
Pars Distalis, Pigmentation, | | |
Hemosiderin | | 4 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 6| 9| 2| 3| 3| 7| 0| 9| 3| 3| 8| 6| 9| 3| 3| 6| 9| 9| 3| 3| 7| 9| 2| 3| 3| |
| 2| 4| 4| 6| 6| 4| 3| 4| 6| 6| 5| 7| 8| 6| 6| 1| 5| 7| 4| 6| 2| 4| 4| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia, Focal | | 1 2.0|
C-Cell, Hyperplasia, Multifocal | | 1 2.0|
Follicle, Cyst | X X | 2 |
Follicle, Hyperplasia, Cystic, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute, Suppurative | 2 | 4 2.5|
Inflammation, Subacute | 2 | 2 2.0|
Duct, Cyst | X X | 3 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 | 1 4.0|
Inflammation, Acute, Suppurative | 1 3 2 2 1 1 4 2 1 2| 19 1.9|
Inflammation, Chronic | 1 1 | 5 1.2|
__________________________________________________________________________|____________|
Testes | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 | 2 2.5|
Inflammation, Acute, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Iliac, Ectasia | 4 | 1 4.0|
Inguinal, Hyperplasia | 2 | 1 2.0|
Mandibular, Ectasia | 2 3 2 2 2| 7 2.3|
Mediastinal, Hyperplasia | 2 | 1 2.0|
Mesenteric, Angiectasis | 3 | 2 2.5|
Mesenteric, Congestion | | 1 2.0|
Mesenteric, Ectasia | 4 2 | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 2 2.5|
Developmental Malformation | 2 | 1 2.0|
Fibrosis | 2 2 | 7 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 6| 9| 2| 3| 3| 7| 0| 9| 3| 3| 8| 6| 9| 3| 3| 6| 9| 9| 3| 3| 7| 9| 2| 3| 3| |
| 2| 4| 4| 6| 6| 4| 3| 4| 6| 6| 5| 7| 8| 6| 6| 1| 5| 7| 4| 6| 2| 4| 4| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Capsule, Fibrosis, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Cyst | X X X X X X X| 10 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alopecia | | 1 |
Cyst Epithelial Inclusion | X| 1 |
Hyperkeratosis, Focal | 3 | 1 3.0|
Hyperplasia, Focal | 2 | 1 2.0|
Inflammation, Acute, Focal, | | |
Suppurative | 2 | 2 2.0|
Inflammation, Focal, Granulomatous | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | | 3 1.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 1 |
Degeneration, Multifocal | 2 | 2 1.5|
Hemorrhage, Multifocal | 3 | 2 2.5|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Cyst | | 1 |
Hemorrhage, Multifocal | | 2 1.5|
Mineralization | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 3 | 3 2.0|
Fungus | 3 3 3 3 | 11 2.9|
Inflammation, Acute, Suppurative | 2 3 2 2 1 | 14 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 6| 9| 2| 3| 3| 7| 0| 9| 3| 3| 8| 6| 9| 3| 3| 6| 9| 9| 3| 3| 7| 9| 2| 3| 3| |
| 2| 4| 4| 6| 6| 4| 3| 4| 6| 6| 5| 7| 8| 6| 6| 1| 5| 7| 4| 6| 2| 4| 4| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Nasolacrimal Duct, Inflammation, | | |
Acute, Suppurative | 1 | 3 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + + + + + + + + | 14 |
__________________________________________________________________________|____________|
Eye | | 4 |
Cataract | | 1 2.0|
Synechia | | 1 2.0|
Cornea, Inflammation, Chronic | | 1 3.0|
Retina, Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 3 3 4 2 3 2 2 2 3 3 2 2 3 4 3 3 2 2 2 1 2 3 2 4 2| 49 2.7|
Cortex, Cyst | | 3 |
Cortex, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 6| 6| 7| 7|
DAY ON TEST | 5| 0| 2| 3| 3| 5| 9| 3| 3| 3| 4| 9| 3| 3| 3| 6| 9| 3| 3| 3| 5| 5| 5| 3| 3|
| 3| 8| 7| 3| 3| 0| 8| 3| 3| 3| 3| 9| 3| 3| 3| 8| 8| 3| 3| 3| 3| 7| 7| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.025% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cecum, Inflammation, Subacute | 2 2|
Colon, Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 1 1 1 2 |
Angiectasis, Multifocal | 2 1 2 1 |
Basophilic Focus | X X X |
Basophilic Focus, Multiple | X X |
Clear Cell Focus | X|
Degeneration, Fatty, Focal | 2 |
Developmental Malformation | 2 2 X 2 |
Eosinophilic Focus, Multiple | |
Granuloma, Focal | 1 |
Granuloma, Multifocal | 2 1 |
Necrosis, Focal | |
Necrosis, Multifocal | 2 |
Vacuolization Cytoplasmic, Diffuse | 1 |
Biliary Tract, Hyperplasia | 2 3 1 2 2 2 2 2 3 2 1 1 2 1 3 2 1 2 2 3 3 2|
Centrilobular, Necrosis | 1 1 2 1 1 1 1 1 |
Hepatocyte, Hypertrophy | 3 1 1 |
__________________________________________________________________________|
Mesentery | + + + |
Hemorrhage | 2 2 |
Inflammation, Diffuse, Subacute | 3 |
Fat, Necrosis, Focal | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 3 3 2 1 |
Artery, Hypertrophy | |
Artery, Inflammation, Subacute | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 |
Forestomach, Hyperkeratosis | 2 2 |
Forestomach, Hyperplasia | 2 2 |
Forestomach, Inflammation, Subacute | 1 |
Forestomach, Ulcer | 4 |
Glandular, Erosion | 2 |
Glandular, Mineralization | 2 |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 6| 6| 7| 7|
DAY ON TEST | 5| 0| 2| 3| 3| 5| 9| 3| 3| 3| 4| 9| 3| 3| 3| 6| 9| 3| 3| 3| 5| 5| 5| 3| 3|
| 3| 8| 7| 3| 3| 0| 8| 3| 3| 3| 3| 9| 3| 3| 3| 8| 8| 3| 3| 3| 3| 7| 7| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.025% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + |
Mineralization | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Multifocal | 2 2 1 2 3 2 2 2 2 2 2 2 2 1 2 1 2 2 1 1|
Mineralization | 1 |
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cortex, Degeneration, Diffuse, Fatty | |
Cortex, Degeneration, Fatty, Focal | 2 2 2 |
Cortex, Degeneration, Fatty, | |
Multifocal | |
Cortex, Hemorrhage, Multifocal | |
Cortex, Hyperplasia, Focal | 2 |
Cortex, Necrosis, Diffuse | 4 |
Cortex, Necrosis, Multifocal | |
Medulla, Hematopoietic Cell | |
Proliferation | 2 2 |
Medulla, Hyperplasia, Focal | 2 |
Medulla, Hyperplasia, Multifocal | 2|
Medulla, Necrosis, Diffuse | 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + M + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 3 2 2 3 3 |
Pars Distalis, Cyst | 2 |
Pars Distalis, Hemorrhage, Focal | |
Pars Distalis, Hyperplasia, Focal | 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 1 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia, Focal | |
C-Cell, Hyperplasia, Multifocal | |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 6| 6| 7| 7|
DAY ON TEST | 5| 0| 2| 3| 3| 5| 9| 3| 3| 3| 4| 9| 3| 3| 3| 6| 9| 3| 3| 3| 5| 5| 5| 3| 3|
| 3| 8| 7| 3| 3| 0| 8| 3| 3| 3| 3| 9| 3| 3| 3| 8| 8| 3| 3| 3| 3| 7| 7| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.025% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + M + M M +|
Hyperplasia | |
Inflammation, Acute, Suppurative | 3 3 2 |
Inflammation, Subacute | |
Duct, Cyst | X X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Edema | |
Inflammation, Acute, Suppurative | 3 1 3 1 3 2 2 4 4 2 3 |
Inflammation, Chronic | |
Inflammation, Subacute | |
__________________________________________________________________________|
Seminal Vesicle | + + |
Inflammation, Acute, Suppurative | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Atrophy | 3 3 |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Congestion | 2 |
Mandibular, Ectasia | 2 1 2 2 |
Mediastinal, Congestion | 1 |
Mesenteric, Angiectasis | 2 |
Mesenteric, Ectasia | 2 |
Pancreatic, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Congestion | |
Fibrosis | 2 2 3 2 2 |
Hematopoietic Cell Proliferation | 3 3 3 3 |
Necrosis, Focal | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + + + M|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + + + + + M + + + + + + + + +|
Granuloma | 3 |
Inflammation, Chronic, Focal | 3|
Pigmentation, Hemosiderin | 3|
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 6| 6| 7| 7|
DAY ON TEST | 5| 0| 2| 3| 3| 5| 9| 3| 3| 3| 4| 9| 3| 3| 3| 6| 9| 3| 3| 3| 5| 5| 5| 3| 3|
| 3| 8| 7| 3| 3| 0| 8| 3| 3| 3| 3| 9| 3| 3| 3| 8| 8| 3| 3| 3| 3| 7| 7| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.025% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Duct, Cyst | X X X X X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 |
Hyperkeratosis, Focal | 2 |
Hyperplasia, Focal | 3 |
Inflammation, Acute, Focal, | |
Suppurative | 2 |
Inflammation, Chronic, Focal | |
Inflammation, Focal, Granulomatous | |
Inflammation, Focal, Subacute | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Compression | |
Degeneration, Multifocal | 2 2 |
Hemorrhage, Multifocal | 3 |
Necrosis, Focal | |
Thrombosis | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Foreign Body | 1 |
Granuloma | 1 |
Inflammation, Multifocal, Subacute | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + M + + + + M + + + +|
Foreign Body | 1 2 2 |
Fungus | 3 3 3 3 |
Hemorrhage | |
Inflammation, Acute, Suppurative | 2 2 2 2 2 2 |
Inflammation, Chronic | |
Nasolacrimal Duct, Inflammation, | |
Acute, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 6| 6| 7| 7|
DAY ON TEST | 5| 0| 2| 3| 3| 5| 9| 3| 3| 3| 4| 9| 3| 3| 3| 6| 9| 3| 3| 3| 5| 5| 5| 3| 3|
| 3| 8| 7| 3| 3| 0| 8| 3| 3| 3| 3| 9| 3| 3| 3| 8| 8| 3| 3| 3| 3| 7| 7| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.025% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Ear | + + + + + + + + +|
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + +|
Cataract | 2 2 3 2 1 2 4 3 3 3 3 2 |
Hemorrhage | 2 2 |
Retina, Degeneration | 2 2 3 2 1 2 4 3 2 3 3 3 2 3 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Inflammation, Acute, Suppurative | |
Nephropathy, Chronic | 2 3 3 3 3 2 2 4 2 3 3 3 2 2 2 1 2 3 2 3 1 4 3 2 2|
Cortex, Cyst | X X |
Cortex, Mineralization | 3 |
Papilla, Necrosis | |
Pelvis, Inflammation, Acute, | |
Suppurative | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Inflammation, Acute, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 8| 9| 1| 3| 3| 9| 3| 3| 3| 3| 6| 6| 8| 3| 3| 7| 6| 3| 3| 3| 2| 2| 3| 3| 3| |
| 2| 4| 5| 3| 3| 5| 3| 3| 3| 3| 7| 4| 0| 3| 3| 6| 7| 3| 3| 3| 9| 2| 3| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.025% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cecum, Inflammation, Subacute | | 2 2.0|
Colon, Parasite Metazoan | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 2 2 1 | 8 1.5|
Angiectasis, Multifocal | 3 1 | 6 1.7|
Basophilic Focus | X X | 5 |
Basophilic Focus, Multiple | | 2 |
Clear Cell Focus | | 1 |
Degeneration, Fatty, Focal | | 1 2.0|
Developmental Malformation | 2 | 5 2.0|
Eosinophilic Focus, Multiple | 3 | 1 3.0|
Granuloma, Focal | | 1 1.0|
Granuloma, Multifocal | | 2 1.5|
Necrosis, Focal | 2 | 1 2.0|
Necrosis, Multifocal | | 1 2.0|
Vacuolization Cytoplasmic, Diffuse | 2 2 1 2 | 5 1.6|
Biliary Tract, Hyperplasia | 3 2 2 1 3 3 2 1 2 2 2 3 2 2 2 2 3 | 39 2.1|
Centrilobular, Necrosis | 1 1 2 1 1 | 13 1.2|
Hepatocyte, Hypertrophy | 1 | 4 1.5|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Hemorrhage | | 2 2.0|
Inflammation, Diffuse, Subacute | | 1 3.0|
Fat, Necrosis, Focal | 3 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 1 2 1 3 | 11 1.9|
Artery, Hypertrophy | 4 | 1 4.0|
Artery, Inflammation, Subacute | 2| 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Subacute | | 1 2.0|
Forestomach, Hyperkeratosis | 1 1 | 4 1.5|
Forestomach, Hyperplasia | 1 1 | 4 1.5|
Forestomach, Inflammation, Subacute | 2 | 2 1.5|
Forestomach, Ulcer | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 8| 9| 1| 3| 3| 9| 3| 3| 3| 3| 6| 6| 8| 3| 3| 7| 6| 3| 3| 3| 2| 2| 3| 3| 3| |
| 2| 4| 5| 3| 3| 5| 3| 3| 3| 3| 7| 4| 0| 3| 3| 6| 7| 3| 3| 3| 9| 2| 3| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.025% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Glandular, Erosion | | 1 2.0|
Glandular, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + | 2 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Multifocal | 2 1 1 2 2 2 1 2 1 1 2 2 1 2 1 2 1 2 2 2| 40 1.7|
Mineralization | | 1 1.0|
Atrium, Thrombosis | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cortex, Degeneration, Diffuse, Fatty | 2 | 1 2.0|
Cortex, Degeneration, Fatty, Focal | 1 1 2| 6 1.7|
Cortex, Degeneration, Fatty, | | |
Multifocal | 2 | 1 2.0|
Cortex, Hemorrhage, Multifocal | 3 | 1 3.0|
Cortex, Hyperplasia, Focal | 1 | 2 1.5|
Cortex, Necrosis, Diffuse | | 1 4.0|
Cortex, Necrosis, Multifocal | 2 3 | 2 2.5|
Medulla, Hematopoietic Cell | | |
Proliferation | | 2 2.0|
Medulla, Hyperplasia, Focal | 3 | 2 2.5|
Medulla, Hyperplasia, Multifocal | | 1 2.0|
Medulla, Necrosis, Diffuse | | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 1 | 3 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 2 2 2 3 | 11 2.5|
Pars Distalis, Cyst | | 1 2.0|
Pars Distalis, Hemorrhage, Focal | 2 | 1 2.0|
Pars Distalis, Hyperplasia, Focal | 2 | 2 2.0|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 1 1 1 1 | 7 1.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 8| 9| 1| 3| 3| 9| 3| 3| 3| 3| 6| 6| 8| 3| 3| 7| 6| 3| 3| 3| 2| 2| 3| 3| 3| |
| 2| 4| 5| 3| 3| 5| 3| 3| 3| 3| 7| 4| 0| 3| 3| 6| 7| 3| 3| 3| 9| 2| 3| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.025% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Ultimobranchial Cyst | X | 1 |
C-Cell, Hyperplasia, Focal | 2 | 1 2.0|
C-Cell, Hyperplasia, Multifocal | 2 | 1 2.0|
Follicle, Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | M + + + + + + M + + M + + + + + + + + + M + + + +| 43 |
Hyperplasia | 3 | 1 3.0|
Inflammation, Acute, Suppurative | 2 2 2 | 6 2.3|
Inflammation, Subacute | 2 | 1 2.0|
Duct, Cyst | | 3 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Edema | 2 | 1 2.0|
Inflammation, Acute, Suppurative | 1 3 2 1 3 2 1 4 | 19 2.4|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Subacute | 4 | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 2 |
Inflammation, Acute, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Atrophy | 3 3 | 4 3.0|
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mandibular, Congestion | | 1 2.0|
Mandibular, Ectasia | 2 2 | 6 1.8|
Mediastinal, Congestion | | 1 1.0|
Mesenteric, Angiectasis | | 1 2.0|
Mesenteric, Ectasia | 2 2 4 | 4 2.5|
Pancreatic, Ectasia | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 8| 9| 1| 3| 3| 9| 3| 3| 3| 3| 6| 6| 8| 3| 3| 7| 6| 3| 3| 3| 2| 2| 3| 3| 3| |
| 2| 4| 5| 3| 3| 5| 3| 3| 3| 3| 7| 4| 0| 3| 3| 6| 7| 3| 3| 3| 9| 2| 3| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.025% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Congestion | 2 | 1 2.0|
Fibrosis | 3 2 | 7 2.3|
Hematopoietic Cell Proliferation | 2 | 5 2.8|
Necrosis, Focal | 3 | 1 3.0|
Pigmentation, Hemosiderin | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + + +| 47 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + M + + M| 46 |
Granuloma | | 1 3.0|
Inflammation, Chronic, Focal | | 1 3.0|
Pigmentation, Hemosiderin | | 1 3.0|
Duct, Cyst | X X X X X X X X X X X X | 22 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | | 1 2.0|
Hyperkeratosis, Focal | | 1 2.0|
Hyperplasia, Focal | 4 | 2 3.5|
Inflammation, Acute, Focal, | | |
Suppurative | | 1 2.0|
Inflammation, Chronic, Focal | 3 | 1 3.0|
Inflammation, Focal, Granulomatous | 2 | 1 2.0|
Inflammation, Focal, Subacute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | X | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bacterium | 2 | 1 2.0|
Compression | X | 1 |
Degeneration, Multifocal | 2 2 1 1 2 | 7 1.7|
Hemorrhage, Multifocal | 3 | 2 3.0|
Necrosis, Focal | 2 | 1 2.0|
Thrombosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | + + | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 8| 9| 1| 3| 3| 9| 3| 3| 3| 3| 6| 6| 8| 3| 3| 7| 6| 3| 3| 3| 2| 2| 3| 3| 3| |
| 2| 4| 5| 3| 3| 5| 3| 3| 3| 3| 7| 4| 0| 3| 3| 6| 7| 3| 3| 3| 9| 2| 3| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.025% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Foreign Body | | 1 1.0|
Granuloma | | 1 1.0|
Inflammation, Multifocal, Subacute | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | M + + + + + + + + M M + + + + + + + + + + + + + +| 45 |
Foreign Body | 2 2 2 1 | 7 1.7|
Fungus | 3 4 4 3 3 3 | 10 3.2|
Hemorrhage | 2 2 | 2 2.0|
Inflammation, Acute, Suppurative | 2 3 2 2 2 2 3 1 | 14 2.1|
Inflammation, Chronic | 3 | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Acute, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Subacute | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + + + + + + +| 17 |
__________________________________________________________________________|____________|
Eye | + + + | 18 |
Cataract | 4 | 13 2.6|
Hemorrhage | | 2 2.0|
Retina, Degeneration | 4 1 | 17 2.4|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | 2 | 1 2.0|
Inflammation, Acute, Suppurative | 4 | 1 4.0|
Nephropathy, Chronic | 2 1 2 3 3 3 2 3 3 3 3 3 3 3 2 2 3 4 4 2 2 3 1 3| 49 2.6|
Cortex, Cyst | | 2 |
Cortex, Mineralization | 2 | 2 2.5|
Papilla, Necrosis | 4 | 1 4.0|
Pelvis, Inflammation, Acute, | | |
Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 4.0|
Inflammation, Acute, Suppurative | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 4| 6| 9| 3| 6| 6| 9| 3| 3| 5| 6| 9| 3| 3| 2| 9| 2| 3| 3| 1| 9| 3| 3| 3|
| 0| 7| 8| 2| 4| 0| 3| 5| 5| 5| 4| 2| 6| 4| 5| 2| 2| 2| 5| 5| 9| 4| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.012% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cecum, Parasite Metazoan | 2 |
Colon, Parasite Metazoan | 2 2 2 2 |
Rectum, Mineralization | |
Rectum, Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Mineralization, Focal | 2 |
Peyer's Patch, Necrosis, Focal | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 3 |
Angiectasis, Multifocal | 2 |
Basophilic Focus | X |
Basophilic Focus, Multiple | |
Congestion | 2 2 2 |
Developmental Malformation | 2 |
Eosinophilic Focus | |
Granuloma, Multifocal | |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage, Multifocal | 2 |
Hepatodiaphragmatic Nodule | |
Necrosis, Multifocal | |
Pigmentation, Hemosiderin, Multifocal| 2 |
Thrombosis | |
Vacuolization Cytoplasmic, Diffuse | 3 |
Vacuolization Cytoplasmic, Focal | 3 |
Vacuolization Cytoplasmic, Multifocal| |
Biliary Tract, Hyperplasia | 2 3 2 1 2 1 2 2 1 2 2 2 3 2 3 2 2 |
Centrilobular, Necrosis | 1 1 2 3 2 1 1 4 |
Hepatocyte, Hypertrophy | 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis, Focal | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 3 2 3 1 2|
Acinus, Hyperplasia | |
Artery, Inflammation, Subacute | 3 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Subacute | |
Forestomach, Edema | 2 |
Forestomach, Hyperkeratosis | 2 |
Forestomach, Hyperplasia | 2 |
Forestomach, Inflammation, Subacute | 2 |
Forestomach, Mineralization | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 4| 6| 9| 3| 6| 6| 9| 3| 3| 5| 6| 9| 3| 3| 2| 9| 2| 3| 3| 1| 9| 3| 3| 3|
| 0| 7| 8| 2| 4| 0| 3| 5| 5| 5| 4| 2| 6| 4| 5| 2| 2| 2| 5| 5| 9| 4| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.012% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Forestomach, Ulcer | |
Glandular, Edema | 2 |
Glandular, Erosion | 2 |
Glandular, Erosion, Multiple | |
Glandular, Mineralization | 2 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Fibrosis, Multifocal | 2 2 1 2 1 1 1 1 1 2 3 3 1 1 2 2 1 1 1 |
Inflammation, Acute, Suppurative | |
Mineralization | |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Cortex, Degeneration, Fatty, Focal | 1 1 2 2 |
Medulla, Hematopoietic Cell | |
Proliferation | 2 |
Medulla, Hyperplasia, Focal | 2 2 |
Medulla, Hyperplasia, Multifocal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + M + + + + + + + + + + + + + M + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 1 2 3 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 3 3 2 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Ultimobranchial Cyst | X X |
C-Cell, Hyperplasia, Focal | 1 3 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 4| 6| 9| 3| 6| 6| 9| 3| 3| 5| 6| 9| 3| 3| 2| 9| 2| 3| 3| 1| 9| 3| 3| 3|
| 0| 7| 8| 2| 4| 0| 3| 5| 5| 5| 4| 2| 6| 4| 5| 2| 2| 2| 5| 5| 9| 4| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.012% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + M + + + + M + + + + + + + + +|
Inflammation, Acute, Suppurative | 3 2 2 3 |
Inflammation, Chronic | |
Duct, Cyst | X X X X |
__________________________________________________________________________|
Prostate | + + + + + + M + + + + + + + + + + + + + + + + + +|
Concretion | 2 |
Fibrosis | 4 |
Inflammation, Acute, Suppurative | 1 1 3 3 2 |
Inflammation, Chronic | 2 |
Inflammation, Subacute | |
__________________________________________________________________________|
Seminal Vesicle | + + |
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 |
Mineralization | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deep Cervical, Congestion | |
Lumbar, Ectasia | 3 |
Mandibular, Ectasia | |
Mesenteric, Ectasia | 2 1|
Pancreatic, Ectasia | |
Pancreatic, Hyperplasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis | 3 2 3 2 |
Hematopoietic Cell Proliferation | 2 2 3 |
Inflammation, Acute, Suppurative | |
Necrosis, Focal | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + M + + + + + M + +|
Cyst | |
Mediastinum, Inflammation, Acute, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | X X X X X X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperkeratosis, Focal | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 4| 6| 9| 3| 6| 6| 9| 3| 3| 5| 6| 9| 3| 3| 2| 9| 2| 3| 3| 1| 9| 3| 3| 3|
| 0| 7| 8| 2| 4| 0| 3| 5| 5| 5| 4| 2| 6| 4| 5| 2| 2| 2| 5| 5| 9| 4| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.012% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hyperplasia, Focal | |
Hyperplasia | 3 |
Inflammation, Acute, Focal, | |
Suppurative | 4 2 |
Inflammation, Chronic, Focal | |
Inflammation, Focal, Subacute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | X |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Degeneration, Multifocal | 1 2 |
Hemorrhage, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage, Multifocal | |
Hyperplasia, Histiocytic | |
Inflammation, Multifocal, Subacute | 2 |
Mineralization | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 3 2 2 |
Fungus | 2 3 3 3 3 3 3 3 3 3 |
Inflammation, Acute, Suppurative | 2 2 2 1 2 1 2 2 2 1 |
Nasolacrimal Duct, Inflammation, | |
Acute, Suppurative | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + + + |
__________________________________________________________________________|
Eye | + + + + + + |
Cataract | 1 1 |
Hemorrhage | 1 |
Cornea, Inflammation, Diffuse, | |
Subacute | |
Cornea, Inflammation, Focal, Subacute| 3 |
Retina, Degeneration | 2 2 2 2 1 |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 4| 6| 9| 3| 6| 6| 9| 3| 3| 5| 6| 9| 3| 3| 2| 9| 2| 3| 3| 1| 9| 3| 3| 3|
| 0| 7| 8| 2| 4| 0| 3| 5| 5| 5| 4| 2| 6| 4| 5| 2| 2| 2| 5| 5| 9| 4| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.012% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Fibrosis, Focal | 4 |
Inflammation, Acute, Suppurative | |
Inflammation, Chronic, Focal | 4 |
Nephropathy, Chronic | 2 2 3 3 3 2 2 2 4 3 3 3 3 4 3 1 4 2 3 3 4 3 3 3|
Pigmentation, Hemosiderin | 4 |
Cortex, Cyst | X |
Cortex, Mineralization | |
Cortex, Necrosis, Focal | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 5| 5| 7| 7| 7| |
DAY ON TEST | 4| 2| 3| 3| 3| 4| 2| 2| 3| 3| 2| 3| 4| 3| 3| 3| 4| 9| 0| 3| 5| 8| 3| 3| 3| |
| 6| 0| 5| 5| 5| 6| 8| 9| 3| 5| 0| 9| 7| 4| 5| 8| 3| 5| 8| 5| 9| 3| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.012% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Cecum, Parasite Metazoan | | 1 2.0|
Colon, Parasite Metazoan | 2 | 5 2.0|
Rectum, Mineralization | 2 | 1 2.0|
Rectum, Parasite Metazoan | 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Peyer's Patch, Mineralization, Focal | | 1 2.0|
Peyer's Patch, Necrosis, Focal | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 1 2 1 2 1| 6 1.7|
Angiectasis, Multifocal | 3 | 2 2.5|
Basophilic Focus | X X X | 4 |
Basophilic Focus, Multiple | X | 1 |
Congestion | | 3 2.0|
Developmental Malformation | | 1 2.0|
Eosinophilic Focus | X X | 2 |
Granuloma, Multifocal | 2 1 | 2 1.5|
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage, Multifocal | | 1 2.0|
Hepatodiaphragmatic Nodule | X | 1 |
Necrosis, Multifocal | 2 | 1 2.0|
Pigmentation, Hemosiderin, Multifocal| | 1 2.0|
Thrombosis | X | 1 |
Vacuolization Cytoplasmic, Diffuse | 2 3 | 3 2.7|
Vacuolization Cytoplasmic, Focal | 2 2 | 3 2.3|
Vacuolization Cytoplasmic, Multifocal| 2 | 1 2.0|
Biliary Tract, Hyperplasia | 2 3 2 2 2 3 4 2 1 2 3 3 3 1 3 2 2 2 2 1| 37 2.1|
Centrilobular, Necrosis | 1 1 1 1 1 1 1 1 1 1 1 | 19 1.4|
Hepatocyte, Hypertrophy | 2 2 1 2 1 1 1 | 8 1.4|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Fat, Necrosis, Focal | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Atrophy | 3 2 4 2 3 2 2 2 1 1| 18 2.2|
Acinus, Hyperplasia | 3 | 1 3.0|
Artery, Inflammation, Subacute | | 2 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Subacute | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 5| 5| 7| 7| 7| |
DAY ON TEST | 4| 2| 3| 3| 3| 4| 2| 2| 3| 3| 2| 3| 4| 3| 3| 3| 4| 9| 0| 3| 5| 8| 3| 3| 3| |
| 6| 0| 5| 5| 5| 6| 8| 9| 3| 5| 0| 9| 7| 4| 5| 8| 3| 5| 8| 5| 9| 3| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.012% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Forestomach, Edema | | 1 2.0|
Forestomach, Hyperkeratosis | 2 | 2 2.0|
Forestomach, Hyperplasia | 2 | 2 2.0|
Forestomach, Inflammation, Subacute | 2 | 2 2.0|
Forestomach, Mineralization | 3 2 | 2 2.5|
Forestomach, Ulcer | 3 | 1 3.0|
Glandular, Edema | | 1 2.0|
Glandular, Erosion | | 1 2.0|
Glandular, Erosion, Multiple | 4 | 1 4.0|
Glandular, Mineralization | 3 4 | 5 2.6|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + | 2 |
Mineralization | 4 3 | 2 3.5|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bacterium | 4 | 1 4.0|
Fibrosis, Multifocal | 1 2 2 2 1 1 2 2 2 1 1 2 2 2 2 2 1 2 1 2 2| 40 1.6|
Inflammation, Acute, Suppurative | 4 | 1 4.0|
Mineralization | 2 3 | 2 2.5|
Atrium, Thrombosis | 4 2 4 | 3 3.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Hyperplasia, Focal | 2 | 1 2.0|
Cortex, Degeneration, Fatty, Focal | 3 | 5 1.8|
Medulla, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
Medulla, Hyperplasia, Focal | 1 2 2 2 2 2 2 2 | 10 1.9|
Medulla, Hyperplasia, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 46 |
Hyperplasia | 2 2 | 4 1.8|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Pars Distalis, Angiectasis | 3| 5 2.0|
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia, Focal | 2 | 5 2.4|
Pars Distalis, Pigmentation, | | |
Hemosiderin | | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 5| 5| 7| 7| 7| |
DAY ON TEST | 4| 2| 3| 3| 3| 4| 2| 2| 3| 3| 2| 3| 4| 3| 3| 3| 4| 9| 0| 3| 5| 8| 3| 3| 3| |
| 6| 0| 5| 5| 5| 6| 8| 9| 3| 5| 0| 9| 7| 4| 5| 8| 3| 5| 8| 5| 9| 3| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.012% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
Ultimobranchial Cyst | | 2 |
C-Cell, Hyperplasia, Focal | | 2 2.0|
Follicle, Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Acute, Suppurative | 1 2 3 3 | 8 2.4|
Inflammation, Chronic | 2 | 1 2.0|
Duct, Cyst | X X | 6 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Concretion | | 1 2.0|
Fibrosis | | 1 4.0|
Inflammation, Acute, Suppurative | 2 2 1 2 2 3 2 2 1 2 1| 16 1.9|
Inflammation, Chronic | | 1 2.0|
Inflammation, Subacute | 2 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 4 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 2 2.5|
Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Deep Cervical, Congestion | 3 | 1 3.0|
Lumbar, Ectasia | 1 | 2 2.0|
Mandibular, Ectasia | 2 2 2 2 2 2 2 | 7 2.0|
Mesenteric, Ectasia | 2 1 1 | 5 1.4|
Pancreatic, Ectasia | 2 | 1 2.0|
Pancreatic, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 5| 5| 7| 7| 7| |
DAY ON TEST | 4| 2| 3| 3| 3| 4| 2| 2| 3| 3| 2| 3| 4| 3| 3| 3| 4| 9| 0| 3| 5| 8| 3| 3| 3| |
| 6| 0| 5| 5| 5| 6| 8| 9| 3| 5| 0| 9| 7| 4| 5| 8| 3| 5| 8| 5| 9| 3| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.012% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Fibrosis | 2 2 2 | 7 2.3|
Hematopoietic Cell Proliferation | 3 | 4 2.5|
Inflammation, Acute, Suppurative | 3 | 1 3.0|
Necrosis, Focal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Cyst | X | 1 |
Mediastinum, Inflammation, Acute, | | |
Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Duct, Cyst | X X X X X X X| 18 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X X | 2 |
Hyperkeratosis, Focal | 2 | 1 2.0|
Hyperplasia, Focal | 2 | 1 2.0|
Hyperplasia | | 1 3.0|
Inflammation, Acute, Focal, | | |
Suppurative | | 2 3.0|
Inflammation, Chronic, Focal | 2 | 1 2.0|
Inflammation, Focal, Subacute | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | X 3 | 3 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X | 1 |
Degeneration, Multifocal | 2 2 | 4 1.8|
Hemorrhage, Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 2 | 3 2.0|
Hemorrhage, Multifocal | 2 | 1 2.0|
Hyperplasia, Histiocytic | 2 | 1 2.0|
Inflammation, Multifocal, Subacute | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05048-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RHODAMINE 6G Date: 05/01/97
Route: DOSED FEED Time: 14:20:05
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 5| 5| 7| 7| 7| |
DAY ON TEST | 4| 2| 3| 3| 3| 4| 2| 2| 3| 3| 2| 3| 4| 3| 3| 3| 4| 9| 0| 3| 5| 8| 3| 3| 3| |
| 6| 0| 5| 5| 5| 6| 8| 9| 3| 5| 0| 9| 7| 4| 5| 8| 3| 5| 8| 5| 9| 3| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.012% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mineralization | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 2 2 2 2| 8 2.1|
Fungus | 3 3 3 3 3 3 3 3 3 3| 20 3.0|
Inflammation, Acute, Suppurative | 2 1 2 2 1 3 2 2 2 2| 20 1.8|
Nasolacrimal Duct, Inflammation, | | |
Acute, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + + +| 8 |
__________________________________________________________________________|____________|
Eye | + + | 8 |
Cataract | 3 | 3 1.7|
Hemorrhage | | 1 1.0|
Cornea, Inflammation, Diffuse, | | |
Subacute | 2 | 1 2.0|
Cornea, Inflammation, Focal, Subacute| | 1 3.0|
Retina, Degeneration | 3 | 6 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bacterium | 3 | 1 3.0|
Fibrosis, Focal | | 1 4.0|
Inflammation, Acute, Suppurative | 3 | 1 3.0|
Inflammation, Chronic, Focal | | 1 4.0|
Nephropathy, Chronic | 2 2 3 3 2 2 2 3 4 2 2 2 3 2 4 1 4 3 2 3 3 3 4 2| 48 2.7|
Pigmentation, Hemosiderin | | 1 4.0|
Cortex, Cyst | X | 2 |
Cortex, Mineralization | 3 4 | 2 3.5|
Cortex, Necrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
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