TR 364 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/07/94
EXP: 05048 RHODAMINE 6G TIME: 00:11:14
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 56122
CONT: N01-ES-28024 CAS: 989-38-8
PATHOLOGIST: H. GILES
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
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REMOVAL DATE RANGE:
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NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/07/94
EXP: 05048 RHODAMINE 6G TIME: 00:11:14
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 56122
CONT: N01-ES-28024 CAS: 989-38-8
PATHOLOGIST: H. GILES
RHODAMINE 6G
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATD CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 28 CENSORED DEATHS 0 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 574 576 585 600 603 603 618 620 621 661 |
| 662 667 668 672 694 694 694 694 695 695 |
| 695 697 698 699 713 724 724 724 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.012% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 29 CENSORED DEATHS 0 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 522 538 559 583 619 620 620 639 643 646 |
| 646 647 647 654 660 662 663 668 692 692 |
| 694 695 695 696 708 720 722 728 729 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.025% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 367 453 468 482 576 629 643 650 653 657 |
| 657 664 667 680 694 695 698 698 699 708 |
| 715 722 727 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
RHODAMINE 6G
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATD | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 88.0 78.0 44.0 |
|CONTROL | |
| | |
|0.012% | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 92.0 66.0 42.0 |
| | |
| | |
|0.025% | 100.0 100.0 100.0 100.0 98.0 92.0 92.0 90.0 76.0 54.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATD 0.012% 0.025% |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 44.0% 42.0% 54.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.421N P=0.809 P=0.461N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 663.2 655.4 634.9 |
|NATURAL DEATHS (C) | ( 9.1) (10.0) (20.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 693.9 688.0 687.9 |
|(STANDARD ERROR) | ( 7.1) ( 8.0) (11.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
RHODAMINE 6G
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATD CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 405 531 533 600 602 607 626 646 653 661 |
| 665 667 669 675 695 695 700 724 725 726 |
| 729 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.012% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 569 572 575 603 638 643 657 660 664 668 |
| 675 696 697 700 722 725 725 728 728 729 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.025% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 361 405 415 531 553 575 620 623 629 631 |
| 635 643 660 662 694 697 727 728 729 729 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
RHODAMINE 6G
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 734 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATD | 100.0 100.0 100.0 100.0 98.0 98.0 94.0 90.0 78.0 58.0 |
|CONTROL | |
| | |
|0.012% | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 92.0 82.0 60.0 |
| | |
| | |
|0.025% | 100.0 100.0 100.0 98.0 94.0 94.0 92.0 88.0 72.0 60.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATD 0.012% 0.025% |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 58.0% 60.0% 60.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.990N P=0.853N P=1.000N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 644.5 668.7 612.4 |
|NATURAL DEATHS (C) | (17.3) (12.2) (24.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 696.4 707.9 685.3 |
|(STANDARD ERROR) | ( 9.5) ( 6.6) (12.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
RHODAMINE 6G
KAPLAN-MEIER SURVIVAL CURVES
UNTREATD CONTROL = 1
0.012% = 2
0.025% = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 2 1
| 3 3 2 2 11
| 3 3 3 2 2 11 1
| 3 32 11 2
P 90 + 3 3
E | 1 13 3
R | 2 233
C | 1 22 1
E 80 +
N | 3 11
T | 22 33 3
| 2 21 3 1
S 70 +
U |
R | 22 2
V | 3 3
I 60 + 22 33
V | 33
A | 3 3
L | 1 1
50 + 121
| 22
| 1 1
| 2
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 17 obs hidden.
RHODAMINE 6G
KAPLAN-MEIER SURVIVAL CURVES
UNTREATD CONTROL = 1
0.012% = 2
0.025% = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
104 +
|
| 1 3 1 2
| 3 1 1
P 96 + 3 3 11 22
E | 3 31 2 12
R | 3 3 2 2
C | 3 3 11
E 88 + 3 1 31 2 2
N | 1 12 2
T | 33 11
| 33 1 12
S 80 + 22
U | 33 112 2
R | 3 3
V | 11
I 72 + 3 1 1 2
V |
A | 3 3
L | 1 1
64 + 3 3
| 2 2
| 1 1
| 1
56 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 8 obs hidden.
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