TR 365 Mouse Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
PENTAERYTHRITOL TETRANITRATE
NTP Experiment-Test: 05023-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/04/94
Route: DOSED FEED Time: 02:05:42
Facility: TSI Mason Research
Chemical CAS #: 78-11-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 02:05:42
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Dead 7 12 7
Moribund 5 8 5
Survivors
Terminal Sacrifice 38 30 38
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (46) (41) (43)
Inflammation, Acute 1 (2%)
Intestine Large, Colon (49) (11) (49)
Parasite 1 (2%)
Intestine Small, Duodenum (46) (11) (43)
Epithelium, Hyperplasia 1 (2%) 1 (2%)
Lymphoid Nodule, Hyperplasia 1 (9%)
Intestine Small, Ileum (47) (11) (46)
Lymphoid Nodule, Mineralization 1 (2%)
Intestine Small, Jejunum (46) (11) (44)
Hyperplasia 1 (9%)
Liver (49) (50) (49)
Basophilic Focus 1 (2%) 1 (2%) 2 (4%)
Clear Cell Focus 1 (2%) 3 (6%) 1 (2%)
Eosinophilic Focus 3 (6%)
Fatty Change, Diffuse 2 (4%) 1 (2%)
Fatty Change, Focal 1 (2%) 5 (10%) 2 (4%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 6 (12%)
Hemorrhage 1 (2%)
Mineralization 1 (2%)
Necrosis 6 (12%) 3 (6%) 2 (4%)
Pigmentation 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Mesentery (6) (1)
Inflammation, Acute 3 (50%)
Fat, Necrosis 3 (50%)
Pancreas (49) (13) (49)
Cyst 1 (8%)
Fibrosis 1 (2%)
Inflammation, Chronic Active 2 (4%) 2 (4%)
Necrosis 2 (4%)
Acinus, Atrophy 2 (4%) 3 (23%) 3 (6%)
Acinus, Hypertrophy 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 02:05:42
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Duct, Dilatation 1 (8%)
Stomach, Forestomach (49) (50) (49)
Acanthosis 2 (4%) 5 (10%) 4 (8%)
Edema 1 (2%)
Hyperkeratosis 11 (22%) 10 (20%) 13 (27%)
Inflammation, Chronic Active 2 (4%) 1 (2%)
Necrosis 2 (4%)
Stomach, Glandular (47) (49) (48)
Hemorrhage 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Chronic Active 3 (6%) 4 (8%) 10 (21%)
Mineralization 2 (4%) 1 (2%) 1 (2%)
Tooth (1)
Incisor, Developmental Malformation 1 (100%)
Incisor, Inflammation, Acute 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (12) (49)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%)
Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (49) (12) (49)
Capsule, Hyperplasia 40 (82%) 7 (58%) 43 (88%)
Adrenal Gland, Cortex (48) (12) (49)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 36 (75%) 7 (58%) 38 (78%)
Hypertrophy 3 (6%) 2 (4%)
Adrenal Gland, Medulla (47) (11) (47)
Hyperplasia 1 (2%) 1 (2%)
Islets, Pancreatic (49) (12) (48)
Hyperplasia 1 (2%)
Pituitary Gland (45) (15) (42)
Pars Distalis, Angiectasis 4 (9%) 2 (13%) 1 (2%)
Pars Distalis, Hyperplasia 8 (18%) 2 (13%) 10 (24%)
Thyroid Gland (47) (12) (47)
Follicular Cell, Hyperplasia 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 02:05:42
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (50) (19) (48)
Abscess 2 (11%)
Angiectasis 3 (6%)
Cyst 9 (18%) 2 (11%) 9 (19%)
Degeneration, Cystic 1 (2%) 6 (32%) 2 (4%)
Hemorrhage 1 (2%) 1 (5%) 2 (4%)
Hyperplasia, Papillary 1 (2%)
Mineralization 2 (4%)
Necrosis 1 (2%)
Pigmentation 2 (4%)
Thrombosis 1 (2%)
Bilateral, Abscess 2 (11%) 1 (2%)
Uterus (49) (37) (49)
Abscess 1 (3%)
Angiectasis 2 (4%) 1 (3%)
Hemorrhage 1 (3%)
Inflammation, Chronic Active 3 (6%) 3 (8%) 2 (4%)
Necrosis 1 (2%)
Pigmentation 1 (3%)
Endometrium, Hyperplasia 36 (73%) 19 (51%) 38 (78%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (12) (49)
Myelofibrosis 5 (10%) 4 (8%)
Lymph Node (50) (17) (48)
Axillary, Hematopoietic Cell Proliferation 1 (6%)
Axillary, Infiltration Cellular, Plasma Cell 1 (6%)
Lumbar, Angiectasis 1 (2%)
Lumbar, Hematopoietic Cell Proliferation 1 (6%)
Lumbar, Infiltration Cellular, Plasma Cell 1 (6%) 1 (2%)
Mediastinal, Angiectasis 1 (2%)
Mediastinal, Infiltration Cellular, Plasma
Cell 2 (12%)
Pancreatic, Hematopoietic Cell Proliferation 1 (2%)
Renal, Hematopoietic Cell Proliferation 1 (6%)
Renal, Infiltration Cellular, Plasma Cell 1 (6%) 1 (2%)
Lymph Node, Mandibular (40) (8) (42)
Hematopoietic Cell Proliferation 2 (5%) 2 (25%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 02:05:42
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Lymphoid 1 (3%)
Lymph Node, Mesenteric (48) (12) (46)
Angiectasis 3 (6%) 1 (8%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 3 (25%) 3 (7%)
Spleen (50) (50) (50)
Angiectasis 1 (2%)
Hematopoietic Cell Proliferation 35 (70%) 20 (40%) 34 (68%)
Hemorrhage 1 (2%)
Necrosis 1 (2%)
Lymphoid Follicle, Hyperplasia 4 (8%) 5 (10%) 2 (4%)
Thymus (42) (10) (40)
Hyperplasia, Lymphoid 1 (10%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (39) (5) (34)
Necrosis 1 (20%)
Acinus, Hyperplasia 1 (3%)
Skin (49) (13) (46)
Inflammation, Chronic Active 1 (2%)
Necrosis 1 (8%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (12) (49)
Mineralization 5 (10%) 2 (4%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (16) (49)
Congestion 1 (2%)
Edema 2 (4%) 1 (2%)
Hemorrhage 6 (12%) 1 (6%) 3 (6%)
Infiltration Cellular, Histiocyte 3 (6%) 1 (6%)
Inflammation, Acute 1 (6%)
Inflammation, Chronic Active 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%)
Pleura, Inflammation, Acute 1 (2%)
Nose (43) (9) (48)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 02:05:42
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Nasolacrimal Duct, Inflammation, Acute 1 (11%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (14) (49)
Casts 1 (2%)
Cyst 2 (4%)
Glomerulosclerosis 1 (2%)
Inflammation, Acute 1 (7%)
Inflammation, Chronic Active 1 (2%)
Papilla, Mineralization 2 (14%) 1 (2%)
Renal Tubule, Pigmentation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 02:05:42
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund 15 6 9
Dead 8 6 3
Survivors
Terminal Sacrifice 26 38 38
Wrong Sex 1
Animals Examined Microscopically 49 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large (47) (8) (47)
Anus, Necrosis 1 (2%)
Intestine Small, Ileum (44) (6) (47)
Lymphoid Nodule, Hyperplasia 1 (2%) 1 (17%) 3 (6%)
Intestine Small, Jejunum (44) (7) (47)
Lymphoid Nodule, Hyperplasia 2 (29%) 2 (4%)
Liver (48) (24) (49)
Angiectasis 2 (8%)
Clear Cell Focus 1 (2%)
Cyst 1 (2%) 1 (4%) 2 (4%)
Eosinophilic Focus 1 (2%)
Fatty Change, Diffuse 1 (2%)
Fatty Change, Focal 6 (13%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (4%)
Infarct 1 (2%)
Mineralization 1 (2%)
Mixed Cell Focus 1 (2%) 2 (4%)
Necrosis 2 (4%) 3 (13%) 2 (4%)
Pigmentation 1 (2%)
Bile Duct, Hyperplasia 1 (2%)
Mesentery (4) (4) (2)
Inflammation, Acute 1 (25%)
Fat, Mineralization 1 (25%) 1 (25%) 1 (50%)
Fat, Necrosis 3 (75%) 4 (100%) 2 (100%)
Pancreas (47) (13) (47)
Acinus, Atrophy 1 (2%)
Acinus, Necrosis 1 (2%)
Artery, Necrosis, Fibrinoid 1 (2%)
Stomach, Forestomach (47) (49) (46)
Acanthosis 3 (6%) 1 (2%)
Hyperkeratosis 3 (6%) 4 (8%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 02:05:42
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Chronic Active 1 (2%) 1 (2%)
Stomach, Glandular (47) (47) (47)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Chronic Active 2 (4%) 6 (13%) 6 (13%)
Mineralization 1 (2%)
Tooth (1)
Incisor, Developmental Malformation 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (46) (13) (48)
Capsule, Hyperplasia 37 (80%) 13 (100%) 45 (94%)
Adrenal Gland, Cortex (46) (13) (48)
Accessory Adrenal Cortical Nodule 1 (2%) 1 (2%)
Hyperplasia 3 (7%) 1 (8%) 6 (13%)
Hypertrophy 7 (15%) 2 (15%) 13 (27%)
Adrenal Gland, Medulla (45) (13) (47)
Hyperplasia 4 (9%) 1 (8%) 8 (17%)
Islets, Pancreatic (47) (13) (46)
Hyperplasia 3 (6%)
Pituitary Gland (45) (8) (48)
Pars Distalis, Cyst 5 (10%)
Pars Intermedia, Hyperplasia 1 (2%) 1 (2%)
Thyroid Gland (46) (8) (46)
Follicle, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (19) (19) (18)
Atrophy 1 (6%)
Dilatation 8 (42%) 5 (26%) 9 (50%)
Inflammation, Acute 1 (6%)
Inflammation, Chronic Active 7 (37%) 6 (32%) 3 (17%)
Mineralization 1 (5%) 1 (5%)
Necrosis 5 (26%) 6 (32%) 5 (28%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 02:05:42
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Prostate (43) (8) (48)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Seminal Vesicle (47) (11) (48)
Bacterium 1 (2%)
Concretion 1 (2%)
Fibrosis 1 (2%)
Testes (48) (9) (49)
Artery, Necrosis, Fibrinoid 1 (2%)
Seminiferous Tubule, Atrophy 2 (4%) 1 (2%)
Seminiferous Tubule, Mineralization 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (46) (23) (47)
Axillary, Angiectasis 1 (2%)
Axillary, Infiltration Cellular, Lymphocyte 1 (2%)
Iliac, Cyst 1 (4%)
Lumbar, Hematopoietic Cell Proliferation 1 (2%)
Mediastinal, Hematopoietic Cell Proliferation 1 (4%)
Mediastinal, Infiltration Cellular, Plasma
Cell 1 (4%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (4%)
Pancreatic, Angiectasis 1 (4%)
Renal, Hematopoietic Cell Proliferation 1 (2%)
Lymph Node, Mandibular (25) (3) (28)
Hematopoietic Cell Proliferation 1 (4%)
Lymph Node, Mesenteric (44) (22) (45)
Angiectasis 22 (50%) 18 (82%) 24 (53%)
Hematopoietic Cell Proliferation 15 (34%) 10 (45%) 20 (44%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (5%)
Spleen (47) (26) (47)
Angiectasis 1 (2%) 1 (2%)
Atrophy 1 (4%)
Depletion Lymphoid 1 (2%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 38 (81%) 12 (46%) 36 (77%)
Hemorrhage 2 (8%)
Thymus (36) (7) (42)
Atrophy 3 (8%)
Depletion Lymphoid 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 02:05:42
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (48) (22) (47)
Acanthosis 2 (4%) 1 (2%)
Hemorrhage 2 (4%)
Hyperkeratosis 1 (2%)
Inflammation, Acute 1 (5%) 1 (2%)
Mineralization 1 (2%)
Necrosis 6 (13%) 3 (14%) 4 (9%)
Prepuce, Fibrosis 1 (2%)
Prepuce, Hemorrhage 1 (2%) 1 (5%)
Prepuce, Inflammation, Acute 2 (4%) 2 (9%)
Prepuce, Inflammation, Chronic Active 1 (5%)
Prepuce, Necrosis 2 (4%) 2 (9%) 1 (2%)
Scrotal, Epithelium, Hyperplasia, Basal Cell 1 (2%)
Subcutaneous Tissue, Mineralization 1 (2%)
Subcutaneous Tissue, Necrosis 1 (5%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (48) (31) (50)
Joint, Hyperostosis 2 (6%)
Tarsal, Hyperostosis 23 (48%) 21 (68%) 25 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (48) (9) (50)
Mineralization 4 (8%) 4 (8%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (47) (17) (50)
Atelectasis 1 (2%)
Congestion 2 (4%) 1 (6%) 4 (8%)
Edema 1 (2%)
Hemorrhage 6 (13%) 1 (6%) 4 (8%)
Infiltration Cellular, Histiocyte 3 (6%) 3 (18%) 3 (6%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%) 1 (6%) 3 (6%)
Nose (40) (7) (48)
Inflammation, Acute 1 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 02:05:42
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1) (3) (5)
Hyperplasia 1 (20%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (47) (13) (49)
Casts Protein 1 (8%) 1 (2%)
Congestion 1 (2%) 2 (4%)
Cyst 1 (2%)
Fibrosis 1 (2%)
Inflammation, Acute 1 (2%) 1 (2%)
Cortex, Mineralization 12 (26%) 3 (23%) 8 (16%)
Papilla, Mineralization 1 (2%) 1 (8%) 1 (2%)
Papilla, Necrosis 1 (2%)
Renal Tubule, Regeneration 1 (8%)
Urinary Bladder (45) (15) (47)
Angiectasis 1 (2%)
Calculus Gross Observation 4 (27%) 2 (4%)
Calculus Micro Observation Only 2 (4%) 5 (33%) 8 (17%)
Inflammation, Chronic Active 2 (4%) 1 (2%)
Mineralization 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
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