TR 365 Mouse Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) PENTAERYTHRITOL TETRANITRATE NTP Experiment-Test: 05023-02 Report: PEIRPT03 Study Type: CHRONIC Date: 09/04/94 Route: DOSED FEED Time: 02:05:42 Facility: TSI Mason Research Chemical CAS #: 78-11-5 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94 Route: DOSED FEED Time: 02:05:42 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 2.5% 5.0% ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 Early Deaths Dead 7 12 7 Moribund 5 8 5 Survivors Terminal Sacrifice 38 30 38 Animals Examined Microscopically 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (46) (41) (43) Inflammation, Acute 1 (2%) Intestine Large, Colon (49) (11) (49) Parasite 1 (2%) Intestine Small, Duodenum (46) (11) (43) Epithelium, Hyperplasia 1 (2%) 1 (2%) Lymphoid Nodule, Hyperplasia 1 (9%) Intestine Small, Ileum (47) (11) (46) Lymphoid Nodule, Mineralization 1 (2%) Intestine Small, Jejunum (46) (11) (44) Hyperplasia 1 (9%) Liver (49) (50) (49) Basophilic Focus 1 (2%) 1 (2%) 2 (4%) Clear Cell Focus 1 (2%) 3 (6%) 1 (2%) Eosinophilic Focus 3 (6%) Fatty Change, Diffuse 2 (4%) 1 (2%) Fatty Change, Focal 1 (2%) 5 (10%) 2 (4%) Fibrosis 1 (2%) Hematopoietic Cell Proliferation 6 (12%) Hemorrhage 1 (2%) Mineralization 1 (2%) Necrosis 6 (12%) 3 (6%) 2 (4%) Pigmentation 1 (2%) 1 (2%) Thrombosis 1 (2%) Mesentery (6) (1) Inflammation, Acute 3 (50%) Fat, Necrosis 3 (50%) Pancreas (49) (13) (49) Cyst 1 (8%) Fibrosis 1 (2%) Inflammation, Chronic Active 2 (4%) 2 (4%) Necrosis 2 (4%) Acinus, Atrophy 2 (4%) 3 (23%) 3 (6%) Acinus, Hypertrophy 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94 Route: DOSED FEED Time: 02:05:42 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 2.5% 5.0% ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Duct, Dilatation 1 (8%) Stomach, Forestomach (49) (50) (49) Acanthosis 2 (4%) 5 (10%) 4 (8%) Edema 1 (2%) Hyperkeratosis 11 (22%) 10 (20%) 13 (27%) Inflammation, Chronic Active 2 (4%) 1 (2%) Necrosis 2 (4%) Stomach, Glandular (47) (49) (48) Hemorrhage 1 (2%) Hyperplasia 1 (2%) Inflammation, Chronic Active 3 (6%) 4 (8%) 10 (21%) Mineralization 2 (4%) 1 (2%) 1 (2%) Tooth (1) Incisor, Developmental Malformation 1 (100%) Incisor, Inflammation, Acute 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (12) (49) Inflammation, Chronic Active 1 (2%) Mineralization 1 (2%) Thrombosis 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland (49) (12) (49) Capsule, Hyperplasia 40 (82%) 7 (58%) 43 (88%) Adrenal Gland, Cortex (48) (12) (49) Hematopoietic Cell Proliferation 1 (2%) Hyperplasia 36 (75%) 7 (58%) 38 (78%) Hypertrophy 3 (6%) 2 (4%) Adrenal Gland, Medulla (47) (11) (47) Hyperplasia 1 (2%) 1 (2%) Islets, Pancreatic (49) (12) (48) Hyperplasia 1 (2%) Pituitary Gland (45) (15) (42) Pars Distalis, Angiectasis 4 (9%) 2 (13%) 1 (2%) Pars Distalis, Hyperplasia 8 (18%) 2 (13%) 10 (24%) Thyroid Gland (47) (12) (47) Follicular Cell, Hyperplasia 1 (2%) 2 (4%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94 Route: DOSED FEED Time: 02:05:42 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 2.5% 5.0% ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (50) (19) (48) Abscess 2 (11%) Angiectasis 3 (6%) Cyst 9 (18%) 2 (11%) 9 (19%) Degeneration, Cystic 1 (2%) 6 (32%) 2 (4%) Hemorrhage 1 (2%) 1 (5%) 2 (4%) Hyperplasia, Papillary 1 (2%) Mineralization 2 (4%) Necrosis 1 (2%) Pigmentation 2 (4%) Thrombosis 1 (2%) Bilateral, Abscess 2 (11%) 1 (2%) Uterus (49) (37) (49) Abscess 1 (3%) Angiectasis 2 (4%) 1 (3%) Hemorrhage 1 (3%) Inflammation, Chronic Active 3 (6%) 3 (8%) 2 (4%) Necrosis 1 (2%) Pigmentation 1 (3%) Endometrium, Hyperplasia 36 (73%) 19 (51%) 38 (78%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (49) (12) (49) Myelofibrosis 5 (10%) 4 (8%) Lymph Node (50) (17) (48) Axillary, Hematopoietic Cell Proliferation 1 (6%) Axillary, Infiltration Cellular, Plasma Cell 1 (6%) Lumbar, Angiectasis 1 (2%) Lumbar, Hematopoietic Cell Proliferation 1 (6%) Lumbar, Infiltration Cellular, Plasma Cell 1 (6%) 1 (2%) Mediastinal, Angiectasis 1 (2%) Mediastinal, Infiltration Cellular, Plasma Cell 2 (12%) Pancreatic, Hematopoietic Cell Proliferation 1 (2%) Renal, Hematopoietic Cell Proliferation 1 (6%) Renal, Infiltration Cellular, Plasma Cell 1 (6%) 1 (2%) Lymph Node, Mandibular (40) (8) (42) Hematopoietic Cell Proliferation 2 (5%) 2 (25%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94 Route: DOSED FEED Time: 02:05:42 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 2.5% 5.0% ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Hyperplasia, Lymphoid 1 (3%) Lymph Node, Mesenteric (48) (12) (46) Angiectasis 3 (6%) 1 (8%) 1 (2%) Hematopoietic Cell Proliferation 1 (2%) 3 (25%) 3 (7%) Spleen (50) (50) (50) Angiectasis 1 (2%) Hematopoietic Cell Proliferation 35 (70%) 20 (40%) 34 (68%) Hemorrhage 1 (2%) Necrosis 1 (2%) Lymphoid Follicle, Hyperplasia 4 (8%) 5 (10%) 2 (4%) Thymus (42) (10) (40) Hyperplasia, Lymphoid 1 (10%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (39) (5) (34) Necrosis 1 (20%) Acinus, Hyperplasia 1 (3%) Skin (49) (13) (46) Inflammation, Chronic Active 1 (2%) Necrosis 1 (8%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (12) (49) Mineralization 5 (10%) 2 (4%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (16) (49) Congestion 1 (2%) Edema 2 (4%) 1 (2%) Hemorrhage 6 (12%) 1 (6%) 3 (6%) Infiltration Cellular, Histiocyte 3 (6%) 1 (6%) Inflammation, Acute 1 (6%) Inflammation, Chronic Active 1 (2%) Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%) Pleura, Inflammation, Acute 1 (2%) Nose (43) (9) (48) a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94 Route: DOSED FEED Time: 02:05:42 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 2.5% 5.0% ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - CONT Nasolacrimal Duct, Inflammation, Acute 1 (11%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (14) (49) Casts 1 (2%) Cyst 2 (4%) Glomerulosclerosis 1 (2%) Inflammation, Acute 1 (7%) Inflammation, Chronic Active 1 (2%) Papilla, Mineralization 2 (14%) 1 (2%) Renal Tubule, Pigmentation 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94 Route: DOSED FEED Time: 02:05:42 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 2.5% 5.0% ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 Early Deaths Moribund 15 6 9 Dead 8 6 3 Survivors Terminal Sacrifice 26 38 38 Wrong Sex 1 Animals Examined Microscopically 49 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large (47) (8) (47) Anus, Necrosis 1 (2%) Intestine Small, Ileum (44) (6) (47) Lymphoid Nodule, Hyperplasia 1 (2%) 1 (17%) 3 (6%) Intestine Small, Jejunum (44) (7) (47) Lymphoid Nodule, Hyperplasia 2 (29%) 2 (4%) Liver (48) (24) (49) Angiectasis 2 (8%) Clear Cell Focus 1 (2%) Cyst 1 (2%) 1 (4%) 2 (4%) Eosinophilic Focus 1 (2%) Fatty Change, Diffuse 1 (2%) Fatty Change, Focal 6 (13%) Fibrosis 1 (2%) Hematopoietic Cell Proliferation 1 (2%) Hemorrhage 1 (4%) Infarct 1 (2%) Mineralization 1 (2%) Mixed Cell Focus 1 (2%) 2 (4%) Necrosis 2 (4%) 3 (13%) 2 (4%) Pigmentation 1 (2%) Bile Duct, Hyperplasia 1 (2%) Mesentery (4) (4) (2) Inflammation, Acute 1 (25%) Fat, Mineralization 1 (25%) 1 (25%) 1 (50%) Fat, Necrosis 3 (75%) 4 (100%) 2 (100%) Pancreas (47) (13) (47) Acinus, Atrophy 1 (2%) Acinus, Necrosis 1 (2%) Artery, Necrosis, Fibrinoid 1 (2%) Stomach, Forestomach (47) (49) (46) Acanthosis 3 (6%) 1 (2%) Hyperkeratosis 3 (6%) 4 (8%) 2 (4%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94 Route: DOSED FEED Time: 02:05:42 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 2.5% 5.0% ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Inflammation, Chronic Active 1 (2%) 1 (2%) Stomach, Glandular (47) (47) (47) Hyperplasia 1 (2%) 1 (2%) Inflammation, Chronic Active 2 (4%) 6 (13%) 6 (13%) Mineralization 1 (2%) Tooth (1) Incisor, Developmental Malformation 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland (46) (13) (48) Capsule, Hyperplasia 37 (80%) 13 (100%) 45 (94%) Adrenal Gland, Cortex (46) (13) (48) Accessory Adrenal Cortical Nodule 1 (2%) 1 (2%) Hyperplasia 3 (7%) 1 (8%) 6 (13%) Hypertrophy 7 (15%) 2 (15%) 13 (27%) Adrenal Gland, Medulla (45) (13) (47) Hyperplasia 4 (9%) 1 (8%) 8 (17%) Islets, Pancreatic (47) (13) (46) Hyperplasia 3 (6%) Pituitary Gland (45) (8) (48) Pars Distalis, Cyst 5 (10%) Pars Intermedia, Hyperplasia 1 (2%) 1 (2%) Thyroid Gland (46) (8) (46) Follicle, Cyst 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Preputial Gland (19) (19) (18) Atrophy 1 (6%) Dilatation 8 (42%) 5 (26%) 9 (50%) Inflammation, Acute 1 (6%) Inflammation, Chronic Active 7 (37%) 6 (32%) 3 (17%) Mineralization 1 (5%) 1 (5%) Necrosis 5 (26%) 6 (32%) 5 (28%) a Number of animals examined microscopically at site and number of animals with lesion Page 8 NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94 Route: DOSED FEED Time: 02:05:42 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 2.5% 5.0% ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - CONT Prostate (43) (8) (48) Inflammation, Chronic Active 1 (2%) 1 (2%) Seminal Vesicle (47) (11) (48) Bacterium 1 (2%) Concretion 1 (2%) Fibrosis 1 (2%) Testes (48) (9) (49) Artery, Necrosis, Fibrinoid 1 (2%) Seminiferous Tubule, Atrophy 2 (4%) 1 (2%) Seminiferous Tubule, Mineralization 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (46) (23) (47) Axillary, Angiectasis 1 (2%) Axillary, Infiltration Cellular, Lymphocyte 1 (2%) Iliac, Cyst 1 (4%) Lumbar, Hematopoietic Cell Proliferation 1 (2%) Mediastinal, Hematopoietic Cell Proliferation 1 (4%) Mediastinal, Infiltration Cellular, Plasma Cell 1 (4%) Mediastinal, Infiltration Cellular, Histiocyte 1 (4%) Pancreatic, Angiectasis 1 (4%) Renal, Hematopoietic Cell Proliferation 1 (2%) Lymph Node, Mandibular (25) (3) (28) Hematopoietic Cell Proliferation 1 (4%) Lymph Node, Mesenteric (44) (22) (45) Angiectasis 22 (50%) 18 (82%) 24 (53%) Hematopoietic Cell Proliferation 15 (34%) 10 (45%) 20 (44%) Hemorrhage 1 (2%) Hyperplasia, Lymphoid 1 (5%) Spleen (47) (26) (47) Angiectasis 1 (2%) 1 (2%) Atrophy 1 (4%) Depletion Lymphoid 1 (2%) Fibrosis 1 (2%) Hematopoietic Cell Proliferation 38 (81%) 12 (46%) 36 (77%) Hemorrhage 2 (8%) Thymus (36) (7) (42) Atrophy 3 (8%) Depletion Lymphoid 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 9 NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94 Route: DOSED FEED Time: 02:05:42 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 2.5% 5.0% ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (48) (22) (47) Acanthosis 2 (4%) 1 (2%) Hemorrhage 2 (4%) Hyperkeratosis 1 (2%) Inflammation, Acute 1 (5%) 1 (2%) Mineralization 1 (2%) Necrosis 6 (13%) 3 (14%) 4 (9%) Prepuce, Fibrosis 1 (2%) Prepuce, Hemorrhage 1 (2%) 1 (5%) Prepuce, Inflammation, Acute 2 (4%) 2 (9%) Prepuce, Inflammation, Chronic Active 1 (5%) Prepuce, Necrosis 2 (4%) 2 (9%) 1 (2%) Scrotal, Epithelium, Hyperplasia, Basal Cell 1 (2%) Subcutaneous Tissue, Mineralization 1 (2%) Subcutaneous Tissue, Necrosis 1 (5%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (48) (31) (50) Joint, Hyperostosis 2 (6%) Tarsal, Hyperostosis 23 (48%) 21 (68%) 25 (50%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (48) (9) (50) Mineralization 4 (8%) 4 (8%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (47) (17) (50) Atelectasis 1 (2%) Congestion 2 (4%) 1 (6%) 4 (8%) Edema 1 (2%) Hemorrhage 6 (13%) 1 (6%) 4 (8%) Infiltration Cellular, Histiocyte 3 (6%) 3 (18%) 3 (6%) Inflammation, Chronic Active 1 (2%) 1 (2%) Alveolar Epithelium, Hyperplasia 2 (4%) 1 (6%) 3 (6%) Nose (40) (7) (48) Inflammation, Acute 1 (3%) 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 10 NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94 Route: DOSED FEED Time: 02:05:42 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 2.5% 5.0% ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Harderian Gland (1) (3) (5) Hyperplasia 1 (20%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (47) (13) (49) Casts Protein 1 (8%) 1 (2%) Congestion 1 (2%) 2 (4%) Cyst 1 (2%) Fibrosis 1 (2%) Inflammation, Acute 1 (2%) 1 (2%) Cortex, Mineralization 12 (26%) 3 (23%) 8 (16%) Papilla, Mineralization 1 (2%) 1 (8%) 1 (2%) Papilla, Necrosis 1 (2%) Renal Tubule, Regeneration 1 (8%) Urinary Bladder (45) (15) (47) Angiectasis 1 (2%) Calculus Gross Observation 4 (27%) 2 (4%) Calculus Micro Observation Only 2 (4%) 5 (33%) 8 (17%) Inflammation, Chronic Active 2 (4%) 1 (2%) Mineralization 1 (2%) Transitional Epithelium, Hyperplasia 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 11 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------ --multipart-boundary Content-type: text/plain Range: bytes 70035-70035/70035 --multipart-boundary--