TR 365 Mouse Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) PENTAERYTHRITOL TETRANITRATE NTP Experiment-Test: 05023-02 Report: PEIRPT05 Study Type: CHRONIC Date: 09/04/94 Route: DOSED FEED Time: 02:05:43 Facility: TSI Mason Research Chemical CAS #: 78-11-5 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94 Route: DOSED FEED Time: 02:05:43 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 2.5% 5.0% ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 Early Deaths Dead 7 12 7 Moribund 5 8 5 Survivors Terminal Sacrifice 38 30 38 Animals Examined Microscopically 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (46) (41) (43) Intestine Large, Colon (49) (11) (49) Intestine Small, Ileum (47) (11) (46) Intestine Small, Jejunum (46) (11) (44) Liver (49) (50) (49) Hemangiosarcoma 1 (2%) 2 (4%) Hepatocellular Carcinoma 1 (2%) Hepatocellular Adenoma 5 (10%) 2 (4%) 1 (2%) Histiocytic Sarcoma, Metastatic, Uterus 1 (2%) Sarcoma, Metastatic, Uncertain Primary Site 1 (2%) Mesentery (6) (1) Sarcoma, Metastatic, Uncertain Primary Site 1 (100%) Pancreas (49) (13) (49) Histiocytic Sarcoma, Metastatic, Uterus 1 (2%) Sarcoma, Metastatic, Uncertain Primary Site 1 (2%) Salivary Glands (49) (12) (48) Stomach, Forestomach (49) (50) (49) Squamous Cell Papilloma 1 (2%) 1 (2%) Stomach, Glandular (47) (49) (48) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (12) (49) Adenocarcinoma, Metastatic, Uterus 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland (49) (12) (49) Adrenal Gland, Cortex (48) (12) (49) Sarcoma, Metastatic, Uncertain Primary Site 1 (2%) Adrenal Gland, Medulla (47) (11) (47) Page 2 NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94 Route: DOSED FEED Time: 02:05:43 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 2.5% 5.0% ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont Pheochromocytoma Benign 1 (2%) Islets, Pancreatic (49) (12) (48) Adenoma 1 (2%) Pituitary Gland (45) (15) (42) Pars Distalis, Adenoma 8 (18%) 3 (20%) 5 (12%) Pars Distalis, Carcinoma 1 (2%) Pars Intermedia, Adenoma 1 (7%) Thyroid Gland (47) (12) (47) Follicular Cell, Adenoma 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (50) (19) (48) Adenocarcinoma, Metastatic, Uterus 1 (2%) Choriocarcinoma 1 (5%) Cystadenoma 1 (2%) 2 (4%) Granulosa Cell Tumor Benign 2 (4%) 1 (5%) Luteoma 1 (2%) Sarcoma, Metastatic, Uncertain Primary Site 1 (2%) Teratoma 1 (2%) Teratoma Malignant 1 (2%) Uterus (49) (37) (49) Adenocarcinoma 1 (2%) Histiocytic Sarcoma 1 (2%) Leiomyoma 1 (3%) Polyp Stromal 3 (6%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (49) (12) (49) Lymph Node (50) (17) (48) Lymph Node, Mandibular (40) (8) (42) Lymph Node, Mesenteric (48) (12) (46) Sarcoma, Metastatic, Uncertain Primary Site 1 (2%) Spleen (50) (50) (50) Hemangiosarcoma 1 (2%) Sarcoma, Metastatic, Uncertain Primary Site 1 (2%) Thymus (42) (10) (40) ____________________________________________________________________________________________________________________________________ Page 3 NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94 Route: DOSED FEED Time: 02:05:43 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 2.5% 5.0% ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (39) (5) (34) Adenoacanthoma 1 (20%) Adenocarcinoma 1 (3%) 2 (40%) 1 (3%) Skin (49) (13) (46) Subcutaneous Tissue, Fibrosarcoma 2 (15%) 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Skeletal Muscle (1) (2) (1) Diaphragm, Sarcoma, Metastatic, Uncertain Primary Site 1 (100%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (12) (49) Carcinoma, Metastatic, Pituitary Gland 1 (2%) Spinal Cord (1) (1) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (16) (49) Adenocarcinoma, Metastatic, Uterus 1 (2%) Alveolar/Bronchiolar Adenoma 2 (4%) 2 (13%) 4 (8%) Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (6%) Carcinoma, Metastatic, Harderian Gland 1 (2%) Alveolar Epithelium, Alveolar/Bronchiolar Adenoma 1 (2%) Pleura, Sarcoma, Metastatic, Uncertain Primary Site 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Harderian Gland (3) (2) (7) Adenoma 2 (67%) 2 (100%) 5 (71%) Carcinoma 1 (33%) ____________________________________________________________________________________________________________________________________ Page 4 NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94 Route: DOSED FEED Time: 02:05:43 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 2.5% 5.0% ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (14) (49) Histiocytic Sarcoma, Metastatic, Uterus 1 (2%) Urinary Bladder (47) (11) (48) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) Histiocytic Sarcoma 1 (2%) Lymphoma Malignant 2 (4%) 1 (2%) Lymphoma Malignant Histiocytic 3 (6%) 3 (6%) Lymphoma Malignant Lymphocytic 1 (2%) 1 (2%) Lymphoma Malignant Mixed 10 (20%) 10 (20%) 10 (20%) Lymphoma Malignant Undifferentiated Cell 6 (12%) 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 5 NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94 Route: DOSED FEED Time: 02:05:43 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 2.5% 5.0% ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 37 29 28 Total Primary Neoplasms 54 38 38 Total Animals with Benign Neoplasms 18 12 18 Total Benign Neoplasms 26 12 22 Total Animals with Malignant Neoplasms 28 22 16 Total Malignant Neoplasms 28 26 16 Total Animals with Metastatic Neoplasms 3 2 Total Metastatic Neoplasm 5 12 Total Animals with Malignant Neoplasms 1 Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 6 NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94 Route: DOSED FEED Time: 02:05:43 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 2.5% 5.0% ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 Early Deaths Moribund 15 6 9 Dead 8 6 3 Survivors Terminal Sacrifice 26 38 38 Wrong Sex 1 Animals Examined Microscopically 49 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (47) (7) (47) Intestine Small, Ileum (44) (6) (47) Intestine Small, Jejunum (44) (7) (47) Liver (48) (24) (49) Fibrosarcoma, Metastatic, Skin 1 (2%) Hemangiosarcoma 1 (2%) 2 (8%) Hepatocellular Carcinoma 3 (6%) 4 (17%) 5 (10%) Hepatocellular Adenoma 8 (17%) 6 (25%) 7 (14%) Hepatocellular Adenoma, Multiple 1 (2%) 1 (4%) Ito Cell Tumor Benign 1 (2%) Squamous Cell Carcinoma, Metastatic, Stomach 1 (4%) Salivary Glands (46) (9) (47) Stomach, Forestomach (47) (49) (46) Squamous Cell Carcinoma 1 (2%) Squamous Cell Papilloma 1 (2%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (48) (9) (50) Carcinoma, Metastatic, Lung 1 (11%) Fibrosarcoma, Metastatic, Skin 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland, Cortex (46) (13) (48) Adenoma 1 (2%) Adrenal Gland, Medulla (45) (13) (47) Pheochromocytoma Benign 1 (2%) 1 (8%) 1 (2%) Pituitary Gland (45) (8) (48) Pars Distalis, Adenoma 1 (2%) Page 7 NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94 Route: DOSED FEED Time: 02:05:43 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 2.5% 5.0% ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont Thyroid Gland (46) (8) (46) Follicular Cell, Adenoma 1 (2%) 1 (2%) Follicular Cell, Carcinoma 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (48) (9) (49) Prostate (43) (8) (48) Testes (48) (9) (49) Interstitial Cell, Adenoma 1 (11%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (46) (23) (47) Mediastinal, Carcinoma, Metastatic, Lung 1 (4%) Lymph Node, Mandibular (25) (3) (28) Pancreatic, Hemangiosarcoma, Metastatic 1 (4%) Lymph Node, Mesenteric (44) (22) (45) Hemangioma 1 (5%) 1 (2%) Spleen (47) (26) (47) Fibrosarcoma, Metastatic, Skin 1 (2%) Hemangiosarcoma 2 (8%) Thymus (36) (7) (42) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (48) (22) (47) Basal Cell Adenoma 1 (2%) Squamous Cell Papilloma 1 (2%) Subcutaneous Tissue, Fibroma 1 (2%) 2 (9%) 1 (2%) Subcutaneous Tissue, Fibroma, Multiple 4 (8%) Subcutaneous Tissue, Fibrosarcoma 12 (25%) 2 (9%) 5 (11%) Subcutaneous Tissue, Fibrosarcoma, Multiple 2 (4%) 3 (6%) Subcutaneous Tissue, Hemangiosarcoma 1 (2%) 1 (5%) 1 (2%) Subcutaneous Tissue, Neurofibrosarcoma, Multiple 1 (5%) Subcutaneous Tissue, Sarcoma 2 (4%) 2 (9%) ____________________________________________________________________________________________________________________________________ Page 8 NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94 Route: DOSED FEED Time: 02:05:43 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 2.5% 5.0% ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (48) (31) (50) Mandible, Osteosarcoma 1 (2%) Synovial Tissue, Sarcoma 1 (3%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (47) (17) (50) Alveolar/Bronchiolar Adenoma 9 (19%) 5 (29%) 1 (2%) Alveolar/Bronchiolar Adenoma, Multiple 2 (4%) 2 (4%) Alveolar/Bronchiolar Carcinoma 1 (2%) 3 (18%) 5 (10%) Carcinoma 1 (6%) Fibrosarcoma, Metastatic, Skin 1 (2%) Mediastinum, Carcinoma, Metastatic, Lung 1 (6%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Harderian Gland (1) (3) (5) Adenoma 1 (100%) 2 (67%) 3 (60%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (47) (13) (49) Renal Tubule, Adenoma 1 (8%) Urinary Bladder (45) (15) (47) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(49) *(50) *(50) Lymphoma Malignant Histiocytic 1 (2%) 1 (2%) Lymphoma Malignant Lymphocytic 2 (4%) Lymphoma Malignant Mixed 4 (8%) 2 (4%) 3 (6%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 9 NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94 Route: DOSED FEED Time: 02:05:43 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 2.5% 5.0% ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 36 28 32 Total Primary Neoplasms 57 46 45 Total Animals with Benign Neoplasms 25 16 19 Total Benign Neoplasms 30 21 20 Total Animals with Malignant Neoplasms 21 21 20 Total Malignant Neoplasms 27 25 25 Total Animals with Metastatic Neoplasms 2 2 Total Metastatic Neoplasm 5 4 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 10 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------ --multipart-boundary Content-type: text/plain Range: bytes 58739-58739/58739 --multipart-boundary--