TR 365 Mouse Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
PENTAERYTHRITOL TETRANITRATE
NTP Experiment-Test: 05023-02 Report: PEIRPT05
Study Type: CHRONIC Date: 09/04/94
Route: DOSED FEED Time: 02:05:43
Facility: TSI Mason Research
Chemical CAS #: 78-11-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 02:05:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Dead 7 12 7
Moribund 5 8 5
Survivors
Terminal Sacrifice 38 30 38
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (46) (41) (43)
Intestine Large, Colon (49) (11) (49)
Intestine Small, Ileum (47) (11) (46)
Intestine Small, Jejunum (46) (11) (44)
Liver (49) (50) (49)
Hemangiosarcoma 1 (2%) 2 (4%)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 5 (10%) 2 (4%) 1 (2%)
Histiocytic Sarcoma, Metastatic, Uterus 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Mesentery (6) (1)
Sarcoma, Metastatic, Uncertain Primary Site 1 (100%)
Pancreas (49) (13) (49)
Histiocytic Sarcoma, Metastatic, Uterus 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Salivary Glands (49) (12) (48)
Stomach, Forestomach (49) (50) (49)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Stomach, Glandular (47) (49) (48)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (12) (49)
Adenocarcinoma, Metastatic, Uterus 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (49) (12) (49)
Adrenal Gland, Cortex (48) (12) (49)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Adrenal Gland, Medulla (47) (11) (47)
Page 2
NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 02:05:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (49) (12) (48)
Adenoma 1 (2%)
Pituitary Gland (45) (15) (42)
Pars Distalis, Adenoma 8 (18%) 3 (20%) 5 (12%)
Pars Distalis, Carcinoma 1 (2%)
Pars Intermedia, Adenoma 1 (7%)
Thyroid Gland (47) (12) (47)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (50) (19) (48)
Adenocarcinoma, Metastatic, Uterus 1 (2%)
Choriocarcinoma 1 (5%)
Cystadenoma 1 (2%) 2 (4%)
Granulosa Cell Tumor Benign 2 (4%) 1 (5%)
Luteoma 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Teratoma 1 (2%)
Teratoma Malignant 1 (2%)
Uterus (49) (37) (49)
Adenocarcinoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Leiomyoma 1 (3%)
Polyp Stromal 3 (6%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (12) (49)
Lymph Node (50) (17) (48)
Lymph Node, Mandibular (40) (8) (42)
Lymph Node, Mesenteric (48) (12) (46)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Spleen (50) (50) (50)
Hemangiosarcoma 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Thymus (42) (10) (40)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 02:05:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (39) (5) (34)
Adenoacanthoma 1 (20%)
Adenocarcinoma 1 (3%) 2 (40%) 1 (3%)
Skin (49) (13) (46)
Subcutaneous Tissue, Fibrosarcoma 2 (15%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (2) (1)
Diaphragm, Sarcoma, Metastatic, Uncertain
Primary Site 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (12) (49)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
Spinal Cord (1) (1)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (16) (49)
Adenocarcinoma, Metastatic, Uterus 1 (2%)
Alveolar/Bronchiolar Adenoma 2 (4%) 2 (13%) 4 (8%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (6%)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Alveolar Epithelium, Alveolar/Bronchiolar
Adenoma 1 (2%)
Pleura, Sarcoma, Metastatic, Uncertain
Primary Site 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (3) (2) (7)
Adenoma 2 (67%) 2 (100%) 5 (71%)
Carcinoma 1 (33%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 02:05:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (14) (49)
Histiocytic Sarcoma, Metastatic, Uterus 1 (2%)
Urinary Bladder (47) (11) (48)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Lymphoma Malignant 2 (4%) 1 (2%)
Lymphoma Malignant Histiocytic 3 (6%) 3 (6%)
Lymphoma Malignant Lymphocytic 1 (2%) 1 (2%)
Lymphoma Malignant Mixed 10 (20%) 10 (20%) 10 (20%)
Lymphoma Malignant Undifferentiated Cell 6 (12%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 02:05:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 37 29 28
Total Primary Neoplasms 54 38 38
Total Animals with Benign Neoplasms 18 12 18
Total Benign Neoplasms 26 12 22
Total Animals with Malignant Neoplasms 28 22 16
Total Malignant Neoplasms 28 26 16
Total Animals with Metastatic Neoplasms 3 2
Total Metastatic Neoplasm 5 12
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 02:05:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund 15 6 9
Dead 8 6 3
Survivors
Terminal Sacrifice 26 38 38
Wrong Sex 1
Animals Examined Microscopically 49 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (47) (7) (47)
Intestine Small, Ileum (44) (6) (47)
Intestine Small, Jejunum (44) (7) (47)
Liver (48) (24) (49)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Hemangiosarcoma 1 (2%) 2 (8%)
Hepatocellular Carcinoma 3 (6%) 4 (17%) 5 (10%)
Hepatocellular Adenoma 8 (17%) 6 (25%) 7 (14%)
Hepatocellular Adenoma, Multiple 1 (2%) 1 (4%)
Ito Cell Tumor Benign 1 (2%)
Squamous Cell Carcinoma, Metastatic, Stomach 1 (4%)
Salivary Glands (46) (9) (47)
Stomach, Forestomach (47) (49) (46)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (48) (9) (50)
Carcinoma, Metastatic, Lung 1 (11%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (46) (13) (48)
Adenoma 1 (2%)
Adrenal Gland, Medulla (45) (13) (47)
Pheochromocytoma Benign 1 (2%) 1 (8%) 1 (2%)
Pituitary Gland (45) (8) (48)
Pars Distalis, Adenoma 1 (2%)
Page 7
NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 02:05:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Thyroid Gland (46) (8) (46)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (48) (9) (49)
Prostate (43) (8) (48)
Testes (48) (9) (49)
Interstitial Cell, Adenoma 1 (11%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (46) (23) (47)
Mediastinal, Carcinoma, Metastatic, Lung 1 (4%)
Lymph Node, Mandibular (25) (3) (28)
Pancreatic, Hemangiosarcoma, Metastatic 1 (4%)
Lymph Node, Mesenteric (44) (22) (45)
Hemangioma 1 (5%) 1 (2%)
Spleen (47) (26) (47)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Hemangiosarcoma 2 (8%)
Thymus (36) (7) (42)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (48) (22) (47)
Basal Cell Adenoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 2 (9%) 1 (2%)
Subcutaneous Tissue, Fibroma, Multiple 4 (8%)
Subcutaneous Tissue, Fibrosarcoma 12 (25%) 2 (9%) 5 (11%)
Subcutaneous Tissue, Fibrosarcoma, Multiple 2 (4%) 3 (6%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%) 1 (5%) 1 (2%)
Subcutaneous Tissue, Neurofibrosarcoma,
Multiple 1 (5%)
Subcutaneous Tissue, Sarcoma 2 (4%) 2 (9%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 02:05:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (48) (31) (50)
Mandible, Osteosarcoma 1 (2%)
Synovial Tissue, Sarcoma 1 (3%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (47) (17) (50)
Alveolar/Bronchiolar Adenoma 9 (19%) 5 (29%) 1 (2%)
Alveolar/Bronchiolar Adenoma, Multiple 2 (4%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 3 (18%) 5 (10%)
Carcinoma 1 (6%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Mediastinum, Carcinoma, Metastatic, Lung 1 (6%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1) (3) (5)
Adenoma 1 (100%) 2 (67%) 3 (60%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (47) (13) (49)
Renal Tubule, Adenoma 1 (8%)
Urinary Bladder (45) (15) (47)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(49) *(50) *(50)
Lymphoma Malignant Histiocytic 1 (2%) 1 (2%)
Lymphoma Malignant Lymphocytic 2 (4%)
Lymphoma Malignant Mixed 4 (8%) 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 9
NTP Experiment-Test: 05023-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 02:05:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 36 28 32
Total Primary Neoplasms 57 46 45
Total Animals with Benign Neoplasms 25 16 19
Total Benign Neoplasms 30 21 20
Total Animals with Malignant Neoplasms 21 21 20
Total Malignant Neoplasms 27 25 25
Total Animals with Metastatic Neoplasms 2 2
Total Metastatic Neoplasm 5 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 10
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