TR 365 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason PENTAERYTHRITOL TETRANITRATE DATE: 09/04/94
EXPERIMENT: 05023 TEST: 02 TIME: 02:15:15
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01CP9561901 ROUTE: DOSED FEED NTP C#: 55743
PATHOLOGIST: K. MURTHY CAS: 78-11-5
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason PENTAERYTHRITOL TETRANITRATE DATE: 09/04/94
EXPERIMENT: 05023 TEST: 02 TIME: 02:15:15
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01CP9561901 ROUTE: DOSED FEED NTP C#: 55743
PATHOLOGIST: K. MURTHY CAS: 78-11-5
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason PENTAERYTHRITOL TETRANITRATE DATE: 09/04/94
EXPERIMENT: 05023 TEST: 02 TIME: 02:15:15
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01CP9561901 ROUTE: DOSED FEED NTP C#: 55743
PATHOLOGIST: K. MURTHY CAS: 78-11-5
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF PENTAERYTHRITOL TETRANITRATE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Skin: Subcutaneous Tissue Fibroma
Fibrosarcoma
Neurofibrosarcoma, Fibrosarcoma, Sarcoma,
Neurofibroma, or Fibroma
Neurofibrosarcoma, Fibrosarcoma, or Sarcoma
All Organs Benign Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Uterus Polyp Stromal
All Organs Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
NOS, or Undifferentiated Cell Type
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 2.5% 5.0% |
| | | |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 2/50 (4%) 3/50 (6%) | 2/50 (4%) 2/50 (4%) 5/50 (10%) |
|ADJUSTED (b) | 2.2% 5.3% 7.2% | 5.3% 6.7% 12.7% |
|TERMINAL (d) | 0/26 (0%) 2/38 (5%) 1/38 (3%) | 2/38 (5%) 2/30 (7%) 4/38 (11%) |
|FIRST INCIDENCE (DAYS) | 456 729 (T) 682 | 730 (T) 730 (T) 663 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.314 P=0.597 P=0.403 | P=0.154 P=0.607 P=0.217 |
|INCIDENTAL TUMOR | P=0.152 P=0.554 P=0.109 | P=0.152 P=0.607 P=0.218 |
|LOGISTIC REGRESSION | P=0.219 P=0.467 P=0.290 | P=0.144 P=0.607 P=0.212 |
|COCHRAN-ARMITAGE | P=0.228 | P=0.146 |
|FISHER EXACT | P=0.508 P=0.316 | P=0.691N P=0.218 |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 2/50 (4%) 3/50 (6%) | 3/50 (6%) 2/50 (4%) 5/50 (10%) |
|ADJUSTED (b) | 2.2% 5.3% 7.2% | 7.9% 6.7% 12.7% |
|TERMINAL (d) | 0/26 (0%) 2/38 (5%) 1/38 (3%) | 3/38 (8%) 2/30 (7%) 4/38 (11%) |
|FIRST INCIDENCE (DAYS) | 456 729 (T) 682 | 730 (T) 730 (T) 663 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.314 P=0.597 P=0.403 | P=0.279 P=0.608N P=0.355 |
|INCIDENTAL TUMOR | P=0.152 P=0.554 P=0.109 | P=0.279 P=0.608N P=0.357 |
|LOGISTIC REGRESSION | P=0.219 P=0.467 P=0.290 | P=0.267 P=0.608N P=0.348 |
|COCHRAN-ARMITAGE | P=0.228 | P=0.274 |
|FISHER EXACT | P=0.508 P=0.316 | P=0.500N P=0.357 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 2.5% 5.0% |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/48 (2%) 2/24 (8%) 0/49 (0%) | 1/49 (2%) 2/50 (4%) 0/49 (0%) |
|ADJUSTED (b) | 3.3% 14.3% 0.0% | 2.7% 6.7% 0.0% |
|TERMINAL (d) | 0/26 (0%) 2/14 (14%) 0/38 (0%) | 1/37 (3%) 2/30 (7%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | 695 729 (T) --- | 730 (T) 730 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.274N P=0.391 P=0.448N | P=0.358N P=0.427 P=0.495N |
|INCIDENTAL TUMOR | P=0.335N P=0.272 P=0.581N | P=0.358N P=0.427 P=0.495N |
|LOGISTIC REGRESSION | P=0.307N P=0.263 P=0.483N | P=0.358N P=0.427 P=0.495N |
|COCHRAN-ARMITAGE | P=0.366N | P=0.360N |
|FISHER EXACT | P=0.256 P=0.495N | P=0.508 P=0.500N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/48 (19%) 7/24 (29%) 7/49 (14%) | 5/49 (10%) 2/50 (4%) 1/49 (2%) |
|ADJUSTED (b) | 26.6% 38.7% 18.4% | 13.5% 5.5% 2.6% |
|TERMINAL (d) | 4/26 (15%) 5/14 (36%) 7/38 (18%) | 5/37 (14%) 0/30 (0%) 1/38 (3%) |
|FIRST INCIDENCE (DAYS) | 414 600 729 (T) | 730 (T) 662 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.124N P=0.606N P=0.169N | P=0.065N P=0.301N P=0.096N |
|INCIDENTAL TUMOR | P=0.300N P=0.226 P=0.402N | P=0.059N P=0.236N P=0.096N |
|LOGISTIC REGRESSION | P=0.274N P=0.246 P=0.343N | P=0.061N P=0.247N P=0.096N |
|COCHRAN-ARMITAGE | P=0.331N | P=0.059N |
|FISHER EXACT | P=0.239 P=0.375N | P=0.210N P=0.102N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 2.5% 5.0% |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/48 (6%) 4/24 (17%) 5/49 (10%) | 1/49 (2%) 0/50 (0%) 0/49 (0%) |
|ADJUSTED (b) | 10.2% 13.3% 13.2% | 2.3% 0.0% 0.0% |
|TERMINAL (d) | 2/26 (8%) 1/14 (7%) 5/38 (13%) | 0/37 (0%) 0/30 (0%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | 601 620 729 (T) | 654 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.503 P=0.428 P=0.563 | P=0.273N P=0.519N P=0.500N |
|INCIDENTAL TUMOR | P=0.334 P=0.115 P=0.487 | P=0.256N P=0.429N P=0.500N |
|LOGISTIC REGRESSION | P=0.366 P=0.165 P=0.455 | P=0.267N P=0.482N P=0.504N |
|COCHRAN-ARMITAGE | P=0.317 | P=0.269N |
|FISHER EXACT | P=0.162 P=0.369 | P=0.495N P=0.500N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/48 (23%) 11/24 (46%) 11/49 (22%) | 6/49 (12%) 2/50 (4%) 1/49 (2%) |
|ADJUSTED (b) | 33.2% 49.1% 28.9% | 15.5% 5.5% 2.6% |
|TERMINAL (d) | 6/26 (23%) 6/14 (43%) 11/38 (29%) | 5/37 (14%) 0/30 (0%) 1/38 (3%) |
|FIRST INCIDENCE (DAYS) | 414 600 729 (T) | 654 662 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.199N P=0.357 P=0.258N | P=0.033N* P=0.203N P=0.056N |
|INCIDENTAL TUMOR | P=0.461N P=0.033 * P=0.501N | P=0.028N* P=0.131N P=0.056N |
|LOGISTIC REGRESSION | P=0.428N P=0.044 * P=0.496N | P=0.029N* P=0.145N P=0.056N |
|COCHRAN-ARMITAGE | P=0.521N | P=0.029N* |
|FISHER EXACT | P=0.044 * P=0.574N | P=0.128N P=0.056N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 2.5% 5.0% |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/48 (23%) 11/24 (46%) 11/49 (22%) | 6/49 (12%) 2/50 (4%) 1/49 (2%) |
|ADJUSTED (b) | 33.2% 49.1% 28.9% | 15.5% 5.5% 2.6% |
|TERMINAL (d) | 6/26 (23%) 6/14 (43%) 11/38 (29%) | 5/37 (14%) 0/30 (0%) 1/38 (3%) |
|FIRST INCIDENCE (DAYS) | 414 600 729 (T) | 654 662 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.199N P=0.357 P=0.258N | P=0.033N* P=0.203N P=0.056N |
|INCIDENTAL TUMOR | P=0.461N P=0.033 * P=0.501N | P=0.028N* P=0.131N P=0.056N |
|LOGISTIC REGRESSION | P=0.428N P=0.044 * P=0.496N | P=0.029N* P=0.145N P=0.056N |
|COCHRAN-ARMITAGE | P=0.521N | P=0.029N* |
|FISHER EXACT | P=0.044 * P=0.574N | P=0.128N P=0.056N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/47 (23%) 5/17 (29%) 3/50 (6%) | 2/50 (4%) 2/16 (13%) 5/49 (10%) |
|ADJUSTED (b) | 40.7% 40.3% 7.9% | 5.3% 100.0% 12.7% |
|TERMINAL (d) | 10/26 (38%) 3/8 (38%) 3/38 (8%) | 2/38 (5%) 1/1 (100%) 4/38 (11%) |
|FIRST INCIDENCE (DAYS) | 727 600 729 (T) | 730 (T) 714 663 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.002N** P=0.563 P=0.002N** | P=0.182 P=0.044 * P=0.217 |
|INCIDENTAL TUMOR | P=0.004N** P=0.306 P=0.003N** | P=0.185 P=0.036 * P=0.218 |
|LOGISTIC REGRESSION | P=0.004N** P=0.268 P=0.002N** | P=0.175 P=0.007 ** P=0.210 |
|COCHRAN-ARMITAGE | P=0.015N* | P=0.167 |
|FISHER EXACT | P=0.425 P=0.015N* | P=0.245 P=0.210 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 2.5% 5.0% |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/47 (2%) 4/17 (24%) 5/50 (10%) | 1/50 (2%) 1/16 (6%) 0/49 (0%) |
|ADJUSTED (b) | 3.8% 38.9% 11.6% | 2.6% 3.2% 0.0% |
|TERMINAL (d) | 1/26 (4%) 3/8 (38%) 2/38 (5%) | 1/38 (3%) 0/1 (0%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 655 652 | 730 (T) 728 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.211 P=0.017 * P=0.196 | P=0.353N P=0.476 P=0.500N |
|INCIDENTAL TUMOR | P=0.144 P=0.006 ** P=0.112 | P=0.352N P=0.456 P=0.500N |
|LOGISTIC REGRESSION | P=0.153 P=0.004 ** P=0.128 | P=0.367N P=0.111 P=0.500N |
|COCHRAN-ARMITAGE | P=0.123 | P=0.355N |
|FISHER EXACT | P=0.015 * P=0.117 | P=0.429 P=0.505N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/47 (23%) 9/17 (53%) 7/50 (14%) | 3/50 (6%) 3/16 (19%) 5/49 (10%) |
|ADJUSTED (b) | 40.7% 76.7% 16.5% | 7.9% 100.0% 12.7% |
|TERMINAL (d) | 10/26 (38%) 6/8 (75%) 4/38 (11%) | 3/38 (8%) 1/1 (100%) 4/38 (11%) |
|FIRST INCIDENCE (DAYS) | 727 600 652 | 730 (T) 714 663 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.037N* P=0.059 P=0.053N | P=0.307 P=0.026 * P=0.355 |
|INCIDENTAL TUMOR | P=0.077N P=0.006 ** P=0.084N | P=0.310 P=0.016 * P=0.357 |
|LOGISTIC REGRESSION | P=0.077N P=0.003 ** P=0.086N | P=0.297 P<0.001 ** P=0.347 |
|COCHRAN-ARMITAGE | P=0.157N | P=0.293 |
|FISHER EXACT | P=0.028 * P=0.176N | P=0.148 P=0.346 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 2.5% 5.0% |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 2.6% 5.4% 2.6% |
|TERMINAL (d) | 0/26 (0%) 0/38 (0%) 0/38 (0%) | 0/38 (0%) 0/30 (0%) 1/38 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 729 586 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.616 P=0.439 P=0.757 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.607N P=0.703 P=0.760 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.622 P=0.506 P=0.756 |
|COCHRAN-ARMITAGE | (e) | P=0.622N |
|FISHER EXACT | (e) (e) | P=0.500 P=0.753N |
|=================================================================================================================================|
| |
|Ovary |
| Cystadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 1/50 (2%) 0/19 (0%) 2/48 (4%) |
|ADJUSTED (b) | | 2.3% 0.0% 5.4% |
|TERMINAL (d) | | 0/38 (0%) 0/5 (0%) 2/37 (5%) |
|FIRST INCIDENCE (DAYS) | | 689 --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.365 P=0.541N P=0.485 |
|INCIDENTAL TUMOR | | P=0.373 P=0.612N P=0.494 |
|LOGISTIC REGRESSION | | P=0.366 P=0.735N P=0.488 |
|COCHRAN-ARMITAGE | | P=0.362 |
|FISHER EXACT | | P=0.725N P=0.485 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 2.5% 5.0% |
| | | |
|=================================================================================================================================|
| |
|Ovary |
| Granulosa Cell Tumor Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 2/50 (4%) 1/19 (5%) 0/48 (0%) |
|ADJUSTED (b) | | 5.3% 20.0% 0.0% |
|TERMINAL (d) | | 2/38 (5%) 1/5 (20%) 0/37 (0%) |
|FIRST INCIDENCE (DAYS) | | 730 (T) 730 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.189N P=0.390 P=0.244N |
|INCIDENTAL TUMOR | | P=0.189N P=0.390 P=0.244N |
|LOGISTIC REGRESSION | | P=0.189N P=0.390 P=0.244N |
|COCHRAN-ARMITAGE | | P=0.177N |
|FISHER EXACT | | P=0.626 P=0.258N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/45 (0%) 0/8 (0%) 1/48 (2%) | 8/45 (18%) 3/15 (20%) 5/42 (12%) |
|ADJUSTED (b) | 0.0% 0.0% 2.8% | 22.9% 100.0% 13.9% |
|TERMINAL (d) | 0/25 (0%) 0/0 1/36 (3%) | 8/35 (23%) 3/3 (100%) 5/36 (14%) |
|FIRST INCIDENCE (DAYS) | --- --- 729 (T) | 730 (T) 730 (T) 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.373 (e) P=0.573 | P=0.218N P=0.016 * P=0.253N |
|INCIDENTAL TUMOR | P=0.373 (e) P=0.573 | P=0.218N P=0.016 * P=0.253N |
|LOGISTIC REGRESSION | P=0.373 (e) P=0.573 | P=0.218N P=0.016 * P=0.253N |
|COCHRAN-ARMITAGE | P=0.311 | P=0.275N |
|FISHER EXACT | (e) P=0.516 | P=0.559 P=0.322N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 2.5% 5.0% |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/45 (0%) 0/8 (0%) 1/48 (2%) | 9/45 (20%) 3/15 (20%) 5/42 (12%) |
|ADJUSTED (b) | 0.0% 0.0% 2.8% | 24.5% 100.0% 13.9% |
|TERMINAL (d) | 0/25 (0%) 0/0 1/36 (3%) | 8/35 (23%) 3/3 (100%) 5/36 (14%) |
|FIRST INCIDENCE (DAYS) | --- --- 729 (T) | 549 730 (T) 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.373 (e) P=0.573 | P=0.150N P=0.107 P=0.176N |
|INCIDENTAL TUMOR | P=0.373 (e) P=0.573 | P=0.148N P=0.158 P=0.177N |
|LOGISTIC REGRESSION | P=0.373 (e) P=0.573 | P=0.182N P=0.208 P=0.217N |
|COCHRAN-ARMITAGE | P=0.311 | P=0.194N |
|FISHER EXACT | (e) P=0.516 | P=0.657N P=0.232N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/49 (10%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 18.0% 5.3% 2.6% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 4/26 (15%) 2/38 (5%) 1/38 (3%) | 0/38 (0%) 0/30 (0%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | 682 729 (T) 729 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.021N* P=0.098N P=0.041N* | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.026N* P=0.122N P=0.052N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.027N* P=0.125N P=0.053N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.057N | (e) |
|FISHER EXACT | P=0.210N P=0.098N | (e) (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 2.5% 5.0% |
| | | |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 14/49 (29%) 2/50 (4%) 8/50 (16%) | 0/50 (0%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 35.8% 4.9% 17.8% | 0.0% 5.6% 2.1% |
|TERMINAL (d) | 4/26 (15%) 0/38 (0%) 3/38 (8%) | 0/38 (0%) 1/30 (3%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | 456 656 564 | --- 630 586 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.026N* P<0.001N** P=0.042N* | P=0.366 P=0.204 P=0.508 |
|INCIDENTAL TUMOR | P=0.257N P=0.007N** P=0.413N | P=0.398 P=0.320 P=0.581 |
|LOGISTIC REGRESSION | P=0.193N P=0.003N** P=0.347N | P=0.359 P=0.240 P=0.510 |
|COCHRAN-ARMITAGE | P=0.061N | P=0.360 |
|FISHER EXACT | P<0.001N** P=0.103N | P=0.247 P=0.500 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 20/49 (41%) 7/50 (14%) 9/50 (18%) | 0/50 (0%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 50.5% 17.0% 20.1% | 0.0% 5.6% 2.1% |
|TERMINAL (d) | 8/26 (31%) 4/38 (11%) 4/38 (11%) | 0/38 (0%) 1/30 (3%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | 456 656 564 | --- 630 586 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.001N** P<0.001N** P=0.003N** | P=0.366 P=0.204 P=0.508 |
|INCIDENTAL TUMOR | P=0.024N* P=0.010N** P=0.057N | P=0.398 P=0.320 P=0.581 |
|LOGISTIC REGRESSION | P=0.015N* P=0.005N** P=0.040N* | P=0.359 P=0.240 P=0.510 |
|COCHRAN-ARMITAGE | P=0.006N** | P=0.360 |
|FISHER EXACT | P=0.003N** P=0.011N* | P=0.247 P=0.500 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 2.5% 5.0% |
| | | |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 15/49 (31%) 5/50 (10%) 8/50 (16%) | 0/50 (0%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 37.5% 12.1% 17.8% | 0.0% 5.6% 2.1% |
|TERMINAL (d) | 4/26 (15%) 2/38 (5%) 3/38 (8%) | 0/38 (0%) 1/30 (3%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | 456 656 564 | --- 630 586 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.016N* P=0.004N** P=0.027N* | P=0.366 P=0.204 P=0.508 |
|INCIDENTAL TUMOR | P=0.195N P=0.055N P=0.344N | P=0.398 P=0.320 P=0.581 |
|LOGISTIC REGRESSION | P=0.136N P=0.026N* P=0.278N | P=0.359 P=0.240 P=0.510 |
|COCHRAN-ARMITAGE | P=0.043N* | P=0.360 |
|FISHER EXACT | P=0.010N** P=0.069N | P=0.247 P=0.500 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.7% 5.1% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/26 (0%) 1/38 (3%) 0/38 (0%) | 0/38 (0%) 0/30 (0%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | 600 698 --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.120N P=0.587N P=0.188N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.251N P=0.550 P=0.363N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.169N P=0.685N P=0.243N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.171N | (e) |
|FISHER EXACT | P=0.684N P=0.242N | (e) (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 2.5% 5.0% |
| | | |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/47 (0%) 2/26 (8%) 0/47 (0%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 12.5% 0.0% | 0.0% 0.0% 2.2% |
|TERMINAL (d) | 0/26 (0%) 2/16 (13%) 0/38 (0%) | 0/38 (0%) 0/30 (0%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) --- | --- --- 646 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.564N P=0.138 (e) | P=0.274 (e) P=0.500 |
|INCIDENTAL TUMOR | P=0.564N P=0.138 (e) | P=0.256 (e) P=0.500 |
|LOGISTIC REGRESSION | P=0.564N P=0.138 (e) | P=0.266 (e) P=0.503 |
|COCHRAN-ARMITAGE | P=0.656 | P=0.269 |
|FISHER EXACT | P=0.124 (e) | (e) P=0.500 |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 2/50 (4%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 5.3% 0.0% | 2.6% 0.0% 2.6% |
|TERMINAL (d) | 0/26 (0%) 2/38 (5%) 0/38 (0%) | 1/38 (3%) 0/30 (0%) 1/38 (3%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) --- | 730 (T) --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.595N P=0.325 (e) | P=0.663 P=0.547N P=0.762 |
|INCIDENTAL TUMOR | P=0.595N P=0.325 (e) | P=0.663 P=0.547N P=0.762 |
|LOGISTIC REGRESSION | P=0.595N P=0.325 (e) | P=0.663 P=0.547N P=0.762 |
|COCHRAN-ARMITAGE | P=0.665N | P=0.669N |
|FISHER EXACT | P=0.253 (e) | P=0.500N P=0.753N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 2.5% 5.0% |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/46 (4%) 0/8 (0%) 2/46 (4%) | 1/47 (2%) 0/12 (0%) 0/47 (0%) |
|ADJUSTED (b) | 7.7% 0.0% 5.3% | 2.8% 0.0% 0.0% |
|TERMINAL (d) | 2/26 (8%) 0/0 2/38 (5%) | 1/36 (3%) 0/0 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 729 (T) | 730 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.448N (e) P=0.552N | P=0.299N (e) P=0.489N |
|INCIDENTAL TUMOR | P=0.448N (e) P=0.552N | P=0.299N (e) P=0.489N |
|LOGISTIC REGRESSION | P=0.448N (e) P=0.552N | P=0.299N (e) P=0.489N |
|COCHRAN-ARMITAGE | P=0.605 | P=0.297N |
|FISHER EXACT | P=0.723N P=0.692N | P=0.797N P=0.500N |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 3/50 (6%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | | 7.9% 0.0% 0.0% |
|TERMINAL (d) | | 3/38 (8%) 0/30 (0%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | | 730 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.043N* P=0.165N P=0.121N |
|INCIDENTAL TUMOR | | P=0.043N* P=0.165N P=0.121N |
|LOGISTIC REGRESSION | | P=0.043N* P=0.165N P=0.121N |
|COCHRAN-ARMITAGE | | P=0.037N* |
|FISHER EXACT | | P=0.121N P=0.121N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 02 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 2.5% 5.0% |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 5/50 (10%) 1/50 (2%) | 1/50 (2%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 3.3% 13.2% 2.5% | 2.6% 6.7% 2.2% |
|TERMINAL (d) | 0/26 (0%) 5/38 (13%) 0/38 (0%) | 1/38 (3%) 2/30 (7%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | 695 729 (T) 694 | 730 (T) 730 (T) 646 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.449N P=0.206 P=0.698N | P=0.617N P=0.417 P=0.760 |
|INCIDENTAL TUMOR | P=0.518N P=0.167 P=0.710 | P=0.620 P=0.417 P=0.760 |
|LOGISTIC REGRESSION | P=0.498N P=0.169 P=0.744N | P=0.620 P=0.417 P=0.762N |
|COCHRAN-ARMITAGE | P=0.585N | P=0.622N |
|FISHER EXACT | P=0.107 P=0.747N | P=0.500 P=0.753N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 6/50 (12%) 2/50 (4%) | 1/50 (2%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 3.3% 15.8% 5.1% | 2.6% 6.7% 2.2% |
|TERMINAL (d) | 0/26 (0%) 6/38 (16%) 1/38 (3%) | 1/38 (3%) 2/30 (7%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | 695 729 (T) 694 | 730 (T) 730 (T) 646 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.586 P=0.138 P=0.606 | P=0.617N P=0.417 P=0.760 |
|INCIDENTAL TUMOR | P=0.524 P=0.110 P=0.485 | P=0.620 P=0.417 P=0.760 |
|LOGISTIC REGRESSION | P=0.537 P=0.109 P=0.521 | P=0.620 P=0.417 P=0.762N |
|COCHRAN-ARMITAGE | P=0.426 | P=0.622N |
|FISHER EXACT | P=0.059 P=0.508 | P=0.500 P=0.753N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 02 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 2.5% 5.0% |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/49 (8%) 5/50 (10%) 4/50 (8%) | 20/50 (40%) 17/50 (34%) 13/50 (26%) |
|ADJUSTED (b) | 13.0% 12.6% 10.5% | 44.1% 41.3% 30.4% |
|TERMINAL (d) | 2/26 (8%) 4/38 (11%) 4/38 (11%) | 13/38 (34%) 8/30 (27%) 9/38 (24%) |
|FIRST INCIDENCE (DAYS) | 578 655 729 (T) | 522 521 463 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.373N P=0.576N P=0.451N | P=0.119N P=0.551 P=0.130N |
|INCIDENTAL TUMOR | P=0.477N P=0.524 P=0.559N | P=0.078N P=0.195N P=0.110N |
|LOGISTIC REGRESSION | P=0.479N P=0.580 P=0.561N | P=0.056N P=0.165N P=0.101N |
|COCHRAN-ARMITAGE | P=0.558N | P=0.084N |
|FISHER EXACT | P=0.513 P=0.631N | P=0.339N P=0.101N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/49 (8%) 5/50 (10%) 4/50 (8%) | 20/50 (40%) 17/50 (34%) 12/50 (24%) |
|ADJUSTED (b) | 13.0% 12.6% 10.5% | 44.1% 41.3% 28.0% |
|TERMINAL (d) | 2/26 (8%) 4/38 (11%) 4/38 (11%) | 13/38 (34%) 8/30 (27%) 8/38 (21%) |
|FIRST INCIDENCE (DAYS) | 578 655 729 (T) | 522 521 463 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.373N P=0.576N P=0.451N | P=0.085N P=0.551 P=0.092N |
|INCIDENTAL TUMOR | P=0.477N P=0.524 P=0.559N | P=0.050N P=0.195N P=0.073N |
|LOGISTIC REGRESSION | P=0.479N P=0.580 P=0.561N | P=0.034N* P=0.165N P=0.067N |
|COCHRAN-ARMITAGE | P=0.558N | P=0.055N |
|FISHER EXACT | P=0.513 P=0.631N | P=0.339N P=0.066N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 02 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 2.5% 5.0% |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 25/49 (51%) 16/50 (32%) 19/50 (38%) | 18/50 (36%) 12/50 (24%) 18/50 (36%) |
|ADJUSTED (b) | 74.9% 38.7% 47.3% | 46.0% 34.5% 44.6% |
|TERMINAL (d) | 18/26 (69%) 13/38 (34%) 17/38 (45%) | 17/38 (45%) 8/30 (27%) 16/38 (42%) |
|FIRST INCIDENCE (DAYS) | 414 600 682 | 689 662 258 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.006N** P=0.002N** P=0.005N** | P=0.535 P=0.356N P=0.581 |
|INCIDENTAL TUMOR | P=0.036N* P=0.011N* P=0.037N* | P=0.543N P=0.252N P=0.585 |
|LOGISTIC REGRESSION | P=0.039N* P=0.013N* P=0.043N* | P=0.521 P=0.239N P=0.581N |
|COCHRAN-ARMITAGE | P=0.113N | P=0.543 |
|FISHER EXACT | P=0.043N* P=0.135N | P=0.138N P=0.582N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 21/49 (43%) 21/50 (42%) 20/50 (40%) | 28/50 (56%) 22/50 (44%) 17/50 (34%) |
|ADJUSTED (b) | 50.5% 47.6% 43.1% | 57.1% 50.9% 38.0% |
|TERMINAL (d) | 7/26 (27%) 15/38 (39%) 12/38 (32%) | 17/38 (45%) 10/30 (33%) 11/38 (29%) |
|FIRST INCIDENCE (DAYS) | 456 620 564 | 338 5 463 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.123N P=0.188N P=0.155N | P=0.045N* P=0.461N P=0.048N* |
|INCIDENTAL TUMOR | P=0.438 P=0.360 P=0.341 | P=0.013N* P=0.055N P=0.019N* |
|LOGISTIC REGRESSION | P=0.506 P=0.478 P=0.387 | P=0.016N* P=0.115N P=0.016N* |
|COCHRAN-ARMITAGE | P=0.426N | P=0.017N* |
|FISHER EXACT | P=0.547N P=0.466N | P=0.159N P=0.022N* |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 02 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 2.5% 5.0% |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 36/49 (73%) 28/50 (56%) 32/50 (64%) | 37/50 (74%) 29/50 (58%) 29/50 (58%) |
|ADJUSTED (b) | 83.4% 62.1% 68.0% | 75.5% 65.3% 64.0% |
|TERMINAL (d) | 19/26 (73%) 21/38 (55%) 23/38 (61%) | 26/38 (68%) 15/30 (50%) 22/38 (58%) |
|FIRST INCIDENCE (DAYS) | 414 600 564 | 338 5 258 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.013N* P=0.003N** P=0.014N* | P=0.124N P=0.449N P=0.127N |
|INCIDENTAL TUMOR | P=0.200N P=0.064N P=0.291N | P=0.054N P=0.036N* P=0.068N |
|LOGISTIC REGRESSION | P=0.175N P=0.019N* P=0.120N | P=0.059N P=0.062N P=0.068N |
|COCHRAN-ARMITAGE | P=0.192N | P=0.060N |
|FISHER EXACT | P=0.054N P=0.212N | P=0.069N P=0.069N |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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