TR 365 Mouse Pathology Tables
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 Facility: TSI Mason Research Chemical CAS #: 78-11-5 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| | 3| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +| Epithelium, Hyperplasia | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + M + + + +| Lymphoid Nodule, Mineralization | 1 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + M + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | | Clear Cell Focus | | Fatty Change, Diffuse | | Fatty Change, Focal | | Fibrosis | 2 | Mineralization | | Necrosis | 1 1 2| Pigmentation | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Acinus, Atrophy | 2 1 | Acinus, Hypertrophy | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 2 | Hyperkeratosis | 2 1 2 2 | Inflammation, Chronic Active | 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 1 | Mineralization | 1| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| Capsule, Hyperplasia | 2 1 2 2 2 2 2 2 2 2 2 1 1 2 1 2 1 2 2 1 1 2| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + M + + + + + + + +| _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| | 3| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Hematopoietic Cell Proliferation | | Hyperplasia | 2 1 2 2 2 2 2 2 2 2 1 1 2 1 2 1 2 1 2| Hypertrophy | 1 1 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + M + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Parathyroid Gland | + + + M + M + M + + M M + + + M M + + + + + M M M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| Pars Distalis, Angiectasis | 1 | Pars Distalis, Hyperplasia | 1 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X X X X | Degeneration, Cystic | | Hemorrhage | | Hyperplasia, Papillary | | __________________________________________________________________________| Oviduct | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 | Inflammation, Chronic Active | 3 2 | Endometrium, Hyperplasia | 2 1 1 1 2 2 2 2 2 2 2 2 2 2 3 3 2 2 2 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + M + + + + + + + + +| Myelofibrosis | 2 2 2 | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Lumbar, Angiectasis | | Mediastinal, Angiectasis | | __________________________________________________________________________| Lymph Node, Mandibular | M + + + M + + + + M + + + + + + + + M + + M + + +| Hematopoietic Cell Proliferation | | Hyperplasia, Lymphoid | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1| Hematopoietic Cell Proliferation | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| | 3| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hematopoietic Cell Proliferation | 2 1 2 2 1 1 1 1 2 1 1 1 1 1 1 1 | Lymphoid Follicle, Hyperplasia | 2 3 2 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + M + + + + + + + + + M| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| Acinus, Hyperplasia | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 1 2 | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Edema | 1 | Hemorrhage | 1 1 | Infiltration Cellular, Histiocyte | 1 | Inflammation, Chronic Active | | Alveolar Epithelium, Hyperplasia | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + M + M + + + + + + M + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + M + + +| _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 6| 6| 3| 7| 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 2| 9| 3| 3| 5| 3| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 4| 3| 3| 3| 1| 8| | | 2| 2| 3| 9| 4| 3| 2| 4| 7| 8| 2| 2| 2| 9| 2| 2| 2| 2| 2| 8| 2| 2| 3| 6| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + M + + + + + + + + + + + + + + M + + + + + +| 47 | __________________________________________________________________________|____________| Gallbladder | + + + A A + + + + A + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + M + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + M + + M M + + + + + + + + + M + + + M +| 45 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + M + A + + + + + M + + + + + + + + + + + + + + +| 46 | Epithelium, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + A + + + M + + + + + + + + + + + + + + + +| 47 | Lymphoid Nodule, Mineralization | | 1 1.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + A A + + + + + + + + + + + + + + + + + + M +| 46 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Basophilic Focus | X | 1 | Clear Cell Focus | X | 1 | Fatty Change, Diffuse | 2 2 | 2 2.0| Fatty Change, Focal | 1 | 1 1.0| Fibrosis | | 1 2.0| Mineralization | 1 | 1 1.0| Necrosis | 1 3 3 | 6 1.8| Pigmentation | 1 | 1 1.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 3 2 | 2 2.5| Acinus, Atrophy | | 2 1.5| Acinus, Hypertrophy | 1 | 1 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 | __________________________________________________________________________|____________| Stomach | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 | Acanthosis | 2 | 2 2.0| Hyperkeratosis | 1 1 1 1 2 2 1| 11 1.5| Inflammation, Chronic Active | 1| 2 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + A + + + + M + + + + A + + + + + + + + + + +| 47 | Inflammation, Chronic Active | 1 | 3 1.0| Mineralization | 1 | 2 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 2 | 1 2.0| Thrombosis | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 5 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 6| 6| 3| 7| 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 2| 9| 3| 3| 5| 3| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 4| 3| 3| 3| 1| 8| | | 2| 2| 3| 9| 4| 3| 2| 4| 7| 8| 2| 2| 2| 9| 2| 2| 2| 2| 2| 8| 2| 2| 3| 6| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Capsule, Hyperplasia | 2 2 1 1 1 2 2 2 2 2 1 2 2 1 2 2 2 1| 40 1.7| __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hematopoietic Cell Proliferation | 2 | 1 2.0| Hyperplasia | 2 2 1 1 2 2 2 2 2 1 2 1 2 2 2 2 1| 36 1.7| Hypertrophy | 1 | 3 1.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + M + M + + + + + + + + + + + + + + + + +| 47 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + M + A M + + + + + + + M + M + + + M + M M + + +| 32 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + M + + M + + + + + + + + + + + M M +| 45 | Pars Distalis, Angiectasis | 1 1 2 | 4 1.3| Pars Distalis, Hyperplasia | 1 1 2 1 2 1| 8 1.3| __________________________________________________________________________|____________| Thyroid Gland | + + + M + + + + + + + + + + + + + + M + + + + + +| 47 | Follicular Cell, Hyperplasia | | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | M | | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X X X X X | 9 | Degeneration, Cystic | 2 | 1 2.0| Hemorrhage | 2 | 1 2.0| Hyperplasia, Papillary | 1 | 1 1.0| __________________________________________________________________________|____________| Oviduct | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + I + + +| 49 | Angiectasis | 2 | 2 1.5| Inflammation, Chronic Active | 2 | 3 2.3| Endometrium, Hyperplasia | 2 1 2 2 1 2 2 2 2 2 1 2 2 2 1| 36 1.9| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Myelofibrosis | 2 1 | 5 1.8| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 6| 6| 3| 7| 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 2| 9| 3| 3| 5| 3| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 4| 3| 3| 3| 1| 8| | | 2| 2| 3| 9| 4| 3| 2| 4| 7| 8| 2| 2| 2| 9| 2| 2| 2| 2| 2| 8| 2| 2| 3| 6| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Lumbar, Angiectasis | 3 | 1 3.0| Mediastinal, Angiectasis | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + M M + M + + + + + + + M + + + + + M + + +| 40 | Hematopoietic Cell Proliferation | 2 1 | 2 1.5| Hyperplasia, Lymphoid | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 | Angiectasis | 1 2 | 3 1.3| Hematopoietic Cell Proliferation | 3 | 1 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 1.0| Hematopoietic Cell Proliferation | 1 1 1 2 3 2 1 1 1 2 2 1 1 2 2 1 1 1 1| 35 1.3| Lymphoid Follicle, Hyperplasia | 2 | 4 2.3| __________________________________________________________________________|____________| Thymus | + + + A M + + M M + + + + M + + + M + + + + + + +| 42 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + M M + M M + M M M M + M + + + M +| 39 | Acinus, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 2 1 | 5 1.4| __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 2 | 1 2.0| Edema | 2 | 2 1.5| Hemorrhage | 1 2 1 1 | 6 1.2| Infiltration Cellular, Histiocyte | 2 1 | 3 1.3| Inflammation, Chronic Active | 2 | 1 2.0| Alveolar Epithelium, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Nose | + M + M + + + + + + + + + + + + + M + + + + + M +| 43 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 6| 6| 3| 7| 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 2| 9| 3| 3| 5| 3| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 4| 3| 3| 3| 1| 8| | | 2| 2| 3| 9| 4| 3| 2| 4| 7| 8| 2| 2| 2| 9| 2| 2| 2| 2| 2| 8| 2| 2| 3| 6| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Eye | + + | 2 | __________________________________________________________________________|____________| Harderian Gland | + + + | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Urinary Bladder | + + + A + + + + + + + + + A + + + + + + + + + + +| 47 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 0| 7| 7| 7| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 8| 7| 3| 3| 3| 3| 7| 3| 3| 1| 6| 8| | 1| 1| 1| 1| 0| 5| 1| 1| 1| 1| 1| 1| 1| 8| 9| 1| 1| 1| 1| 4| 1| 1| 8| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + M + + + + +| __________________________________________________________________________| Gallbladder | + + + + + A + + + A + + + + + + + + + + + + + + +| Inflammation, Acute | | __________________________________________________________________________| Intestine Large | + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + A + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + A + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + M + + +| Lymphoid Nodule, Hyperplasia | | __________________________________________________________________________| Intestine Small, Ileum | + + A + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + A A + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X | Clear Cell Focus | X | Fatty Change, Diffuse | 1 | Fatty Change, Focal | 1 1 | Hematopoietic Cell Proliferation | 2 2 3 2 2 | Hemorrhage | | Necrosis | 1 2 | __________________________________________________________________________| Mesentery | + + | Inflammation, Acute | 2 3 | Fat, Necrosis | | __________________________________________________________________________| Pancreas | + + + + + +| Cyst | | Acinus, Atrophy | 1 | Duct, Dilatation | | __________________________________________________________________________| Salivary Glands | + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 2 2 | Hyperkeratosis | 2 2 1 2 | Necrosis | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Inflammation, Chronic Active | 1 | Mineralization | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + +| _____________________________________________________________________________________________________________________| Page 9 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 0| 7| 7| 7| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 8| 7| 3| 3| 3| 3| 7| 3| 3| 1| 6| 8| | 1| 1| 1| 1| 0| 5| 1| 1| 1| 1| 1| 1| 1| 8| 9| 1| 1| 1| 1| 4| 1| 1| 8| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Capsule, Hyperplasia | 2 2 2 2 2| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + +| Hyperplasia | 2 2 2 2 2| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + +| Pars Distalis, Angiectasis | 2 | Pars Distalis, Hyperplasia | 1| __________________________________________________________________________| Thyroid Gland | + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + + + + + + +| Abscess | 4 4 | Cyst | X | Degeneration, Cystic | 2 4 3 3 3| Hemorrhage | 3 | Bilateral, Abscess | 4 | __________________________________________________________________________| Oviduct | + + | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + +| Abscess | 3 | Angiectasis | 2 | Hemorrhage | | Inflammation, Chronic Active | 2 1 | Pigmentation | | Endometrium, Hyperplasia | 2 3 3 2 3 3 2 3 3 3 2 2 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + +| Axillary, Hematopoietic Cell | | Proliferation | 1 | Axillary, Infiltration Cellular, | | Plasma Cell | 2 | Lumbar, Hematopoietic Cell | | Proliferation | 2 | Lumbar, Infiltration Cellular, | | Plasma Cell | 2 | Mediastinal, Infiltration Cellular, | | Plasma Cell | 2 3 | Renal, Hematopoietic Cell | | _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 0| 7| 7| 7| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 8| 7| 3| 3| 3| 3| 7| 3| 3| 1| 6| 8| | 1| 1| 1| 1| 0| 5| 1| 1| 1| 1| 1| 1| 1| 8| 9| 1| 1| 1| 1| 4| 1| 1| 8| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Proliferation | 2 | Renal, Infiltration Cellular, Plasma | | Cell | 2 | __________________________________________________________________________| Lymph Node, Mandibular | + + M + + + +| Hematopoietic Cell Proliferation | 2 2| __________________________________________________________________________| Lymph Node, Mesenteric | + M M + + + +| Angiectasis | 2 | Hematopoietic Cell Proliferation | 2 1 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 2 3 3 1 3 3 2 2 2 2 3| Lymphoid Follicle, Hyperplasia | 2 3 | __________________________________________________________________________| Thymus | + + M + + +| Hyperplasia, Lymphoid | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M M + M +| Necrosis | | __________________________________________________________________________| Skin | + + + + + + +| Necrosis | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + +| __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + +| __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + +| Hemorrhage | 1 | Infiltration Cellular, Histiocyte | | Inflammation, Acute | | __________________________________________________________________________| Nose | + + + + + +| Nasolacrimal Duct, Inflammation, | | Acute | 3 | __________________________________________________________________________| Trachea | + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + +| _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 0| 7| 7| 7| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 8| 7| 3| 3| 3| 3| 7| 3| 3| 1| 6| 8| | 1| 1| 1| 1| 0| 5| 1| 1| 1| 1| 1| 1| 1| 8| 9| 1| 1| 1| 1| 4| 1| 1| 8| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Inflammation, Acute | | Papilla, Mineralization | 1 | __________________________________________________________________________| Urinary Bladder | + + + + + +| _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| | DAY ON TEST | 3| 3| 1| 6| 2| 3| 3| 3| 3| 3| 3| 3| 9| 3| 6| 3| 3| 3| 2| 7| 3| 3| 2| 7| 2| | | 1| 1| 4| 8| 1| 1| 1| 1| 1| 1| 2| 2| 6| 4| 8| 2| 2| 2| 8| 4| 2| 2| 8| 0| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + +| 12 | __________________________________________________________________________|____________| Gallbladder | + + A A A + + + + + + + + + A + + + A + + + A +| 41 | Inflammation, Acute | 1 | 1 1.0| __________________________________________________________________________|____________| Intestine Large | A + + + + +| 11 | __________________________________________________________________________|____________| Intestine Large, Cecum | A + + + + +| 10 | __________________________________________________________________________|____________| Intestine Large, Colon | A + + + + +| 11 | __________________________________________________________________________|____________| Intestine Large, Rectum | A + M + + +| 9 | __________________________________________________________________________|____________| Intestine Small | + + + + + A +| 15 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + A + + + A +| 11 | Lymphoid Nodule, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + A +| 11 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + A + A + A +| 11 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | | 1 | Clear Cell Focus | X X | 3 | Fatty Change, Diffuse | | 1 1.0| Fatty Change, Focal | 2 1 2 | 5 1.4| Hematopoietic Cell Proliferation | 3 | 6 2.3| Hemorrhage | 2 | 1 2.0| Necrosis | 1 | 3 1.3| __________________________________________________________________________|____________| Mesentery | + + + +| 6 | Inflammation, Acute | 3| 3 2.7| Fat, Necrosis | 4 3 4 | 3 3.7| __________________________________________________________________________|____________| Pancreas | + + M + + + + A +| 13 | Cyst | X | 1 | Acinus, Atrophy | 4 3 | 3 2.7| Duct, Dilatation | 3 | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | M + + + + +| 12 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 1 3 1 | 5 1.8| Hyperkeratosis | 2 2 2 2 2 2 | 10 1.9| Necrosis | 2 | 2 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 | Hemorrhage | 1 | 1 1.0| Inflammation, Chronic Active | 1 2 1 | 4 1.3| Mineralization | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| | DAY ON TEST | 3| 3| 1| 6| 2| 3| 3| 3| 3| 3| 3| 3| 9| 3| 6| 3| 3| 3| 2| 7| 3| 3| 2| 7| 2| | | 1| 1| 4| 8| 1| 1| 1| 1| 1| 1| 2| 2| 6| 4| 8| 2| 2| 2| 8| 4| 2| 2| 8| 0| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Heart | + + + + + +| 12 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + +| 12 | Capsule, Hyperplasia | 2 2| 7 2.0| __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + +| 12 | Hyperplasia | 2 2| 7 2.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + M +| 11 | __________________________________________________________________________|____________| Islets, Pancreatic | + M + + + + A +| 12 | __________________________________________________________________________|____________| Parathyroid Gland | M + + + M M| 8 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + A +| 15 | Pars Distalis, Angiectasis | 2 | 2 2.0| Pars Distalis, Hyperplasia | 1 | 2 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + +| 12 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | + + + + + + + + +| 19 | Abscess | | 2 4.0| Cyst | X | 2 | Degeneration, Cystic | 2 | 6 2.8| Hemorrhage | | 1 3.0| Bilateral, Abscess | 4| 2 4.0| __________________________________________________________________________|____________| Oviduct | + + | 4 | __________________________________________________________________________|____________| Uterus | + A + + + + + + + + + + + + + +| 37 | Abscess | | 1 3.0| Angiectasis | | 1 2.0| Hemorrhage | 2 | 1 2.0| Inflammation, Chronic Active | 2| 3 1.7| Pigmentation | 2 | 1 2.0| Endometrium, Hyperplasia | 2 2 3 3 2 2 | 19 2.5| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + +| 12 | __________________________________________________________________________|____________| Lymph Node | + + + + + M + + +| 17 | Axillary, Hematopoietic Cell | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| | DAY ON TEST | 3| 3| 1| 6| 2| 3| 3| 3| 3| 3| 3| 3| 9| 3| 6| 3| 3| 3| 2| 7| 3| 3| 2| 7| 2| | | 1| 1| 4| 8| 1| 1| 1| 1| 1| 1| 2| 2| 6| 4| 8| 2| 2| 2| 8| 4| 2| 2| 8| 0| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Proliferation | | 1 1.0| Axillary, Infiltration Cellular, | | | Plasma Cell | | 1 2.0| Lumbar, Hematopoietic Cell | | | Proliferation | | 1 2.0| Lumbar, Infiltration Cellular, | | | Plasma Cell | | 1 2.0| Mediastinal, Infiltration Cellular, | | | Plasma Cell | | 2 2.5| Renal, Hematopoietic Cell | | | Proliferation | | 1 2.0| Renal, Infiltration Cellular, Plasma | | | Cell | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | M + M M + M| 8 | Hematopoietic Cell Proliferation | | 2 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + A + + + M + + +| 12 | Angiectasis | | 1 2.0| Hematopoietic Cell Proliferation | 2| 3 1.7| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 2 1 2 2 3 2 3| 20 2.3| Lymphoid Follicle, Hyperplasia | 2 2 2 | 5 2.2| __________________________________________________________________________|____________| Thymus | + + + M + +| 10 | Hyperplasia, Lymphoid | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + M M + M M| 5 | Necrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + + +| 13 | Necrosis | | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + +| 12 | __________________________________________________________________________|____________| Skeletal Muscle | + + | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + +| 12 | __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| | DAY ON TEST | 3| 3| 1| 6| 2| 3| 3| 3| 3| 3| 3| 3| 9| 3| 6| 3| 3| 3| 2| 7| 3| 3| 2| 7| 2| | | 1| 1| 4| 8| 1| 1| 1| 1| 1| 1| 2| 2| 6| 4| 8| 2| 2| 2| 8| 4| 2| 2| 8| 0| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + +| 16 | Hemorrhage | | 1 1.0| Infiltration Cellular, Histiocyte | 2 | 1 2.0| Inflammation, Acute | 2| 1 2.0| __________________________________________________________________________|____________| Nose | M + + M M +| 9 | Nasolacrimal Duct, Inflammation, | | | Acute | | 1 3.0| __________________________________________________________________________|____________| Trachea | + + + + + + + +| 16 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | __________________________________________________________________________|____________| Harderian Gland | + | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + +| 14 | Inflammation, Acute | 2| 1 2.0| Papilla, Mineralization | 1 | 2 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + A +| 11 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 16 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 7| 0| 3| 3| 3| 8| 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| | 0| 0| 0| 0| 1| 0| 0| 0| 5| 5| 0| 0| 0| 9| 3| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + M + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + A + + + + + + + + + M + M + + A + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + A + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +| Parasite | | __________________________________________________________________________| Intestine Large, Rectum | + + + + A + + + + + + + + + A + + + + + + + M + +| __________________________________________________________________________| Intestine Small | + + + + A + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + A + + + + + + + + + A + + + + A + + + + +| Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Intestine Small, Ileum | + + + + A + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + A + + + + + + + + + A + + + + A + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + A + + + + + + + + + +| Basophilic Focus | | Clear Cell Focus | | Eosinophilic Focus | X X | Fatty Change, Focal | 1 1 | Necrosis | 2 2 | Pigmentation | 2 | Thrombosis | X | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + M + + + + + + + + + +| Fibrosis | | Inflammation, Chronic Active | 2 | Necrosis | | Acinus, Atrophy | 1 4 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + + + + + +| Acanthosis | 1 1 | Edema | 1 | Hyperkeratosis | 2 2 2 1 1 1 1 | Inflammation, Chronic Active | 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + A + + + + A + + + + +| Hyperplasia | | Inflammation, Chronic Active | 2 1 2 1 2 1 1| Mineralization | 1 | __________________________________________________________________________| Tooth | | Incisor, Developmental Malformation | | Incisor, Inflammation, Acute | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + A + + + + + + + + + +| Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| Page 17 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 7| 0| 3| 3| 3| 8| 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| | 0| 0| 0| 0| 1| 0| 0| 0| 5| 5| 0| 0| 0| 9| 3| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| Capsule, Hyperplasia | 1 1 2 1 2 1 2 1 2 2 2 2 2 2 2 1 1 2 3 1 2| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + M + + + + + + + + + +| Hyperplasia | 1 1 2 2 1 2 1 2 2 2 2 2 2 1 1 2 3 1 2| Hypertrophy | 2 1| __________________________________________________________________________| Adrenal Gland, Medulla | + + M + + + + + + + + + + + M + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + M + + + + + + + + + M + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M + + + M + + M M M M + M + M + + M + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + M + + + M + + + + M M + + + + + M + + + +| Pars Distalis, Angiectasis | | Pars Distalis, Hyperplasia | 1 1 2 | __________________________________________________________________________| Thyroid Gland | + + + + M + + + + + + + + + M + + + + + + + + + +| Follicular Cell, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + M + + + + + + + + + +| Angiectasis | 2 | Cyst | X X X X X X | Degeneration, Cystic | 2 | Hemorrhage | | Mineralization | 2 | Necrosis | | Pigmentation | 2 | Thrombosis | X | Bilateral, Abscess | | __________________________________________________________________________| Oviduct | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + M + + + + + + + + + +| Inflammation, Chronic Active | 2 | Necrosis | 1 | Endometrium, Hyperplasia | 2 2 2 2 3 2 2 2 3 2 2 3 2 3 2 2 3 2 2 2 2| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + A + + + + + + + + + +| Myelofibrosis | 1 1 | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Lumbar, Infiltration Cellular, | | Plasma Cell | 2 | Pancreatic, Hematopoietic Cell | | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 7| 0| 3| 3| 3| 8| 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| | 0| 0| 0| 0| 1| 0| 0| 0| 5| 5| 0| 0| 0| 9| 3| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Proliferation | 1 | Renal, Infiltration Cellular, Plasma | | Cell | 2 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + M + + M + + M M + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + M M + + + + + + + + +| Angiectasis | | Hematopoietic Cell Proliferation | 1 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 2 1 1 2 1 2 2 2 2 1 1 1 2 1 2 2| Hemorrhage | | Necrosis | | Lymphoid Follicle, Hyperplasia | | __________________________________________________________________________| Thymus | + + M + + + + + + + M + + + M + M + + M + + + + M| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + M M M + + + + + + + + M + + + + M + + M M +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + M + + + + + + + M + +| Inflammation, Chronic Active | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + A + + + + + + + + + +| Mineralization | 2 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + A + + + + + + + + + +| Edema | 1 | Hemorrhage | 1 2| Alveolar Epithelium, Hyperplasia | | Pleura, Inflammation, Acute | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + A + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + A + + + + + + + + + +| Casts | | Cyst | | _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 7| 0| 3| 3| 3| 8| 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| | 0| 0| 0| 0| 1| 0| 0| 0| 5| 5| 0| 0| 0| 9| 3| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Glomerulosclerosis | | Inflammation, Chronic Active | | Papilla, Mineralization | | Renal Tubule, Pigmentation | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + M + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 0| 3| 3| 6| 4| 8| | | 1| 1| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 4| 7| 1| 1| 3| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + M +| 48 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + A + + + M A +| 43 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + A +| 46 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite | 1 | 1 1.0| __________________________________________________________________________|____________| Intestine Large, Rectum | M + + + + + + + + + + + + + + + + A + + + + + A +| 44 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + A + A + + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A A A + + + A +| 43 | Epithelium, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + A + + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + A + + + A +| 44 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Basophilic Focus | X X | 2 | Clear Cell Focus | X | 1 | Eosinophilic Focus | X | 3 | Fatty Change, Focal | | 2 1.0| Necrosis | | 2 2.0| Pigmentation | | 1 2.0| Thrombosis | | 1 | __________________________________________________________________________|____________| Mesentery | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Fibrosis | 1 | 1 1.0| Inflammation, Chronic Active | 3 | 2 2.5| Necrosis | 2 2 | 2 2.0| Acinus, Atrophy | 1 | 3 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + M +| 48 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acanthosis | 1 1 | 4 1.0| Edema | | 1 1.0| Hyperkeratosis | 1 1 2 2 1 1 | 13 1.4| Inflammation, Chronic Active | | 1 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hyperplasia | 2 | 1 2.0| Inflammation, Chronic Active | 2 1 2 | 10 1.5| Mineralization | | 1 1.0| __________________________________________________________________________|____________| Tooth | + | 1 | Incisor, Developmental Malformation | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 21 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 0| 3| 3| 6| 4| 8| | | 1| 1| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 4| 7| 1| 1| 3| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Incisor, Inflammation, Acute | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Capsule, Hyperplasia | 2 2 2 2 1 1 1 1 2 2 2 1 2 2 2 3 2 2 2 2 1 2| 43 1.7| __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 2 2 1 1 1 1 2 2 1 2 2 2 2 2 2 2 2 1 | 38 1.7| Hypertrophy | | 2 1.5| __________________________________________________________________________|____________| Adrenal Gland, Medulla | M + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + M M M + M + + + + + M + + + + M + M +| 34 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + M + M M + + + +| 42 | Pars Distalis, Angiectasis | 2 | 1 2.0| Pars Distalis, Hyperplasia | 2 1 2 2 1 2 2 | 10 1.6| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 47 | Follicular Cell, Hyperplasia | 1 | 2 1.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 | Angiectasis | 3 2 | 3 2.3| Cyst | X X X | 9 | Degeneration, Cystic | 2 | 2 2.0| Hemorrhage | 2 1 | 2 1.5| Mineralization | 2 | 2 2.0| Necrosis | 2 | 1 2.0| Pigmentation | 2 | 2 2.0| Thrombosis | | 1 | Bilateral, Abscess | 3 | 1 3.0| __________________________________________________________________________|____________| Oviduct | + + + + + + + + + + + + + + + + + M + + + + + +| 43 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 3 | 2 2.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 22 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 0| 3| 3| 6| 4| 8| | | 1| 1| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 4| 7| 1| 1| 3| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Necrosis | | 1 1.0| Endometrium, Hyperplasia | 2 2 2 2 2 2 2 2 2 1 2 2 2 2 1 2 3 | 38 2.1| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Myelofibrosis | 2 1 | 4 1.3| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + M + + + + M +| 48 | Lumbar, Infiltration Cellular, | | | Plasma Cell | | 1 2.0| Pancreatic, Hematopoietic Cell | | | Proliferation | | 1 1.0| Renal, Infiltration Cellular, Plasma | | | Cell | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M M + + + M M +| 42 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M + + + + M +| 46 | Angiectasis | 1 | 1 1.0| Hematopoietic Cell Proliferation | 1 3 | 3 1.7| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 2 2 2 1 3 3 1 3| 34 1.5| Hemorrhage | 2 | 1 2.0| Necrosis | 4 | 1 4.0| Lymphoid Follicle, Hyperplasia | 3 2 | 2 2.5| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + M + + + M + + + + M M +| 40 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + M + + M M M M + M + M + + + + + + + + + + M + M| 34 | __________________________________________________________________________|____________| Skin | + M + + + + M + + + + + + + + + + + + + + + + + +| 46 | Inflammation, Chronic Active | | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Mineralization | | 2 1.5| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 0| 3| 3| 6| 4| 8| | | 1| 1| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 4| 7| 1| 1| 3| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Edema | | 1 1.0| Hemorrhage | 1 | 3 1.3| Alveolar Epithelium, Hyperplasia | 2 | 1 2.0| Pleura, Inflammation, Acute | 3 | 1 3.0| __________________________________________________________________________|____________| Nose | + M + + + + + + + + + + + + M + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 3 | __________________________________________________________________________|____________| Harderian Gland | + + + + + + | 7 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Casts | 2 | 1 2.0| Cyst | X X | 2 | Glomerulosclerosis | 2 | 1 2.0| Inflammation, Chronic Active | 2 | 1 2.0| Papilla, Mineralization | 1 | 1 1.0| Renal Tubule, Pigmentation | | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 2| 2| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6| DAY ON TEST | 3| 3| 3| 8| 8| 3| 3| 4| 0| 8| 3| 3| 3| 3| 2| 3| 3| 3| 6| 5| 3| 1| 6| 6| 0| | 1| 1| 1| 2| 2| 1| 2| 7| 7| 4| 1| 1| 1| 2| 7| 1| 1| 1| 7| 0| 2| 5| 0| 0| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + A M + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + M A A + + + + A + + + + + + A + A +| __________________________________________________________________________| Intestine Large | + + + + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + A M + + + + A + + + + + + A + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + M A M + + + + A + + + + M + A + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + A + + + + + A + + + + + + A + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + M A + + + + + A + + + + + + A + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + A M + + + + A + + + + + + A + + +| Lymphoid Nodule, Hyperplasia | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + A M + + + + A + + + + + + A + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Eosinophilic Focus | | Fatty Change, Diffuse | | Fatty Change, Focal | 1 2 1 2| Hematopoietic Cell Proliferation | | Infarct | 3 | Mineralization | 2 | Mixed Cell Focus | | Necrosis | | Pigmentation | 2 | Bile Duct, Hyperplasia | 2 | __________________________________________________________________________| Mesentery | + + | Inflammation, Acute | | Fat, Mineralization | | Fat, Necrosis | 3 4 | __________________________________________________________________________| Pancreas | + + + + + + + + M + + + + + + + + + + + + + + + +| Acinus, Necrosis | | Artery, Necrosis, Fibrinoid | | __________________________________________________________________________| Salivary Glands | + + + + + + + + A + + + + + + + + + + + + + + A +| __________________________________________________________________________| Stomach | + + + + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + A + + + + + + + + + + + + + + + +| Acanthosis | | Hyperkeratosis | 1 | Inflammation, Chronic Active | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + A + + + + + + + + + + + + + + + +| Hyperplasia | 1 | Inflammation, Chronic Active | 2 | Mineralization | | __________________________________________________________________________| Tooth | + | Incisor, Developmental Malformation | 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 25 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 2| 2| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6| DAY ON TEST | 3| 3| 3| 8| 8| 3| 3| 4| 0| 8| 3| 3| 3| 3| 2| 3| 3| 3| 6| 5| 3| 1| 6| 6| 0| | 1| 1| 1| 2| 2| 1| 2| 7| 7| 4| 1| 1| 1| 2| 7| 1| 1| 1| 7| 0| 2| 5| 0| 0| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | __________________________________________________________________________| Heart | + + + + + + + + A + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| Capsule, Hyperplasia | 1 1 1 2 1 1 1 1 1 1 1 2 1 2 1 1 1 1| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + M + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | | Hyperplasia | 2 2 2 | Hypertrophy | 1 1 1 1 1 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + M + + + + + + + + + + + + + + + +| Hyperplasia | 1| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + M + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | + + + M + M + M M + + M + + + + M + + M M + M M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + M + + + M + + + + + + + + + + +| Pars Intermedia, Hyperplasia | 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + M + + + + + M + + + + + + + + + +| Follicle, Cyst | 4 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + M + + + + + + M| Dilatation | 2 2 2 2 2 | Inflammation, Chronic Active | 1 2 2 1 | Mineralization | | Necrosis | 3 1 | __________________________________________________________________________| Prostate | + + M + + M + M A + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + A + + + + + + + + + + + + + + + +| Bacterium | 2 | Concretion | 2 | Fibrosis | 2 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Artery, Necrosis, Fibrinoid | | Seminiferous Tubule, Atrophy | 1 2 | Seminiferous Tubule, Mineralization | 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + M M + + + + + + + + + + + + + + + +| Axillary, Angiectasis | 2 | _____________________________________________________________________________________________________________________| Page 26 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 2| 2| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6| DAY ON TEST | 3| 3| 3| 8| 8| 3| 3| 4| 0| 8| 3| 3| 3| 3| 2| 3| 3| 3| 6| 5| 3| 1| 6| 6| 0| | 1| 1| 1| 2| 2| 1| 2| 7| 7| 4| 1| 1| 1| 2| 7| 1| 1| 1| 7| 0| 2| 5| 0| 0| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Axillary, Infiltration Cellular, | | Lymphocyte | 2 | Lumbar, Hematopoietic Cell | | Proliferation | | Renal, Hematopoietic Cell | | Proliferation | | __________________________________________________________________________| Lymph Node, Mandibular | + M M + + M M M M + M + M + + M + M M M + + M M +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + M M M + + + + + + + + + + + + + + +| Angiectasis | 1 2 2 2 1 2 1 1 2 2 2 1| Hematopoietic Cell Proliferation | 1 1 1 1 2 2 2 1 2 | __________________________________________________________________________| Spleen | + + + + + + + + A + + + + + + + + + + + + + + + +| Angiectasis | | Hematopoietic Cell Proliferation | 2 1 1 1 1 2 3 1 2 2 1 1 1 1 3 2 1 3 2 | __________________________________________________________________________| Thymus | + + + + + M + + M + + + + + M + + M + + + + M + +| Atrophy | 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + M M M M M M M M M M M M M M M M M M + M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | | Hemorrhage | 2 | Necrosis | 2 1 2 | Prepuce, Hemorrhage | 2 | Prepuce, Inflammation, Acute | 3 | Prepuce, Necrosis | 4 4 | Scrotal, Epithelium, Hyperplasia, | | Basal Cell | 2 | Subcutaneous Tissue, Mineralization | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Tarsal, Hyperostosis | 2 1 2 2 3 2 3 3 2 2 3 3 3 3 4| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 2 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + A + + + + + + + + + + + + + + + +| Atelectasis | | Congestion | 2 1 | Edema | | Hemorrhage | 1 1 | Infiltration Cellular, Histiocyte | 1 1 | _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 2| 2| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6| DAY ON TEST | 3| 3| 3| 8| 8| 3| 3| 4| 0| 8| 3| 3| 3| 3| 2| 3| 3| 3| 6| 5| 3| 1| 6| 6| 0| | 1| 1| 1| 2| 2| 1| 2| 7| 7| 4| 1| 1| 1| 2| 7| 1| 1| 1| 7| 0| 2| 5| 0| 0| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Inflammation, Chronic Active | 2 | Alveolar Epithelium, Hyperplasia | 1 | __________________________________________________________________________| Nose | + + + + + + + + M + + M + + + M + + + + + + M M +| Inflammation, Acute | | __________________________________________________________________________| Trachea | + + + + + + + + A + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + A + + + + + + + + + + + + + + + +| Congestion | 2 | Cyst | X | Fibrosis | 1 | Inflammation, Acute | 2 | Cortex, Mineralization | 1 1 2 2 1 1 1 1 | Papilla, Mineralization | 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + A + + + + + A + + + + + + A + + +| Calculus Micro Observation Only | X | Inflammation, Chronic Active | 1 2 | Transitional Epithelium, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 5| 5| 4| 7| 7| 7| 6| 0| 7| 5| 4| 7| 7| 6| 5| 4| 7| | DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 8| 6| 5| 3| 3| 3| 2| 2| 3| 7| 5| 3| 1| 0| 4| 1| 3| | | 1| 1| 1| 1| 5| 2| 2| 2| 5| 4| 6| 2| 2| 2| 3| 6| 2| 8| 6| 2| 7| 0| 3| 4| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + M + + + + + + + + A + M + + + + + + + M + + +| 43 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + A + + + + + + + + + + + M +| 41 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + A + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + M + + + A + + + + + + M + + + + + +| 40 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + A + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + +| 44 | Lymphoid Nodule, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + A + + + + + + + + + + + + +| 48 | Cyst | X | 1 | Eosinophilic Focus | X | 1 | Fatty Change, Diffuse | 2| 1 2.0| Fatty Change, Focal | 1 1 | 6 1.3| Hematopoietic Cell Proliferation | 2 | 1 2.0| Infarct | | 1 3.0| Mineralization | | 1 2.0| Mixed Cell Focus | X | 1 | Necrosis | 3 2| 2 2.5| Pigmentation | | 1 2.0| Bile Duct, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Mesentery | + + | 4 | Inflammation, Acute | 3 | 1 3.0| Fat, Mineralization | 1 | 1 1.0| Fat, Necrosis | 3 | 3 3.3| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + A + + + + + + + + + + + + +| 47 | Acinus, Necrosis | 1 | 1 1.0| Artery, Necrosis, Fibrinoid | 3 | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + A + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + A + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + A + + + + + + + + + + + + +| 47 | Acanthosis | 1 1 2| 3 1.3| Hyperkeratosis | 2 2| 3 1.7| Inflammation, Chronic Active | 1 | 1 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + A + + + + + + + + + + + + +| 47 | Hyperplasia | | 1 1.0| Inflammation, Chronic Active | 2 | 2 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 29 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 5| 5| 4| 7| 7| 7| 6| 0| 7| 5| 4| 7| 7| 6| 5| 4| 7| | DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 8| 6| 5| 3| 3| 3| 2| 2| 3| 7| 5| 3| 1| 0| 4| 1| 3| | | 1| 1| 1| 1| 5| 2| 2| 2| 5| 4| 6| 2| 2| 2| 3| 6| 2| 8| 6| 2| 7| 0| 3| 4| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Mineralization | 1 | 1 1.0| __________________________________________________________________________|____________| Tooth | | 1 | Incisor, Developmental Malformation | | 1 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + M + A + + + + + + + + + + + + +| 46 | Capsule, Hyperplasia | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 2 1 1 1| 37 1.2| __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + M + A + + + + + + + + + + + + +| 46 | Accessory Adrenal Cortical Nodule | X | 1 | Hyperplasia | | 3 2.0| Hypertrophy | 1 1 | 7 1.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + M + A + + + + + + + + + + M + +| 45 | Hyperplasia | 1 1 1 | 4 1.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + A + + + + + + + + + + + + +| 47 | Hyperplasia | 2 2 2 | 3 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + M + + + + + + A + + + M + + M + M + M + M| 32 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + A + + + + + M + + + + + + +| 45 | Pars Intermedia, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + A + + + + + + + + + + + + +| 46 | Follicle, Cyst | | 1 4.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + A + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + | 19 | Dilatation | 2 2 3 | 8 2.1| Inflammation, Chronic Active | 2 1 1 | 7 1.4| Mineralization | 2 | 1 2.0| Necrosis | 2 2 2 | 5 2.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + A + + + + + + + + + + + M +| 43 | Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + A + + + + + + + + + + + + +| 47 | Bacterium | | 1 2.0| Concretion | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 30 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 5| 5| 4| 7| 7| 7| 6| 0| 7| 5| 4| 7| 7| 6| 5| 4| 7| | DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 8| 6| 5| 3| 3| 3| 2| 2| 3| 7| 5| 3| 1| 0| 4| 1| 3| | | 1| 1| 1| 1| 5| 2| 2| 2| 5| 4| 6| 2| 2| 2| 3| 6| 2| 8| 6| 2| 7| 0| 3| 4| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Fibrosis | | 1 2.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + A + + + + + + + + + + + + +| 48 | Artery, Necrosis, Fibrinoid | 2 | 1 2.0| Seminiferous Tubule, Atrophy | | 2 1.5| Seminiferous Tubule, Mineralization | | 1 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + A + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + A + + + + + + + + + + + + +| 46 | Axillary, Angiectasis | | 1 2.0| Axillary, Infiltration Cellular, | | | Lymphocyte | | 1 2.0| Lumbar, Hematopoietic Cell | | | Proliferation | 2 | 1 2.0| Renal, Hematopoietic Cell | | | Proliferation | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + M + M + M A M + + M M + M M + M + + +| 25 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + M + + + + + + + A + + + + + + + + + + + + +| 44 | Angiectasis | 2 2 1 3 3 2 2 3 1 2| 22 1.8| Hematopoietic Cell Proliferation | 1 3 1 2 1 2 | 15 1.5| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + A + + + + + + + + + + + + +| 47 | Angiectasis | 2 | 1 2.0| Hematopoietic Cell Proliferation | 1 2 1 3 2 3 3 3 3 1 1 3 1 1 2 1 1 3 3 | 38 1.8| __________________________________________________________________________|____________| Thymus | M + M + + M M M + + A + M + + M + + + + + + + +| 36 | Atrophy | 3 3 | 3 2.7| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M + M M M M M M M + M M M M + M M M| 5 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + A + + + + + + + + + + + + +| 48 | Acanthosis | 1 2| 2 1.5| Hemorrhage | 2 | 2 2.0| Necrosis | 3 2 3 | 6 2.2| Prepuce, Hemorrhage | | 1 2.0| Prepuce, Inflammation, Acute | 3 | 2 3.0| Prepuce, Necrosis | | 2 4.0| Scrotal, Epithelium, Hyperplasia, | | | Basal Cell | | 1 2.0| Subcutaneous Tissue, Mineralization | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 31 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 5| 5| 4| 7| 7| 7| 6| 0| 7| 5| 4| 7| 7| 6| 5| 4| 7| | DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 8| 6| 5| 3| 3| 3| 2| 2| 3| 7| 5| 3| 1| 0| 4| 1| 3| | | 1| 1| 1| 1| 5| 2| 2| 2| 5| 4| 6| 2| 2| 2| 3| 6| 2| 8| 6| 2| 7| 0| 3| 4| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + A + + + + + + + + + + + + +| 48 | Tarsal, Hyperostosis | 3 3 4 1 3 2 2 2 | 23 2.5| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + A + + + + + + + + + + + + +| 48 | Mineralization | 1 | 4 1.8| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + A + + + + + + + + + + + + +| 47 | Atelectasis | 2 | 1 2.0| Congestion | | 2 1.5| Edema | 2 | 1 2.0| Hemorrhage | 2 3 1 2 | 6 1.7| Infiltration Cellular, Histiocyte | 1 | 3 1.0| Inflammation, Chronic Active | | 1 2.0| Alveolar Epithelium, Hyperplasia | 2 | 2 1.5| __________________________________________________________________________|____________| Nose | + M + + + M + + + + A + + + + M + + + + + + + +| 40 | Inflammation, Acute | 1 | 1 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + A + + + + + + + + + + + + +| 47 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | __________________________________________________________________________|____________| Harderian Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + A + + + + + + + + + + + + +| 47 | Congestion | | 1 2.0| Cyst | | 1 | Fibrosis | | 1 1.0| Inflammation, Acute | | 1 2.0| Cortex, Mineralization | 1 1 1 1 | 12 1.2| Papilla, Mineralization | | 1 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + A + + + + + + + + + + + + +| 45 | Calculus Micro Observation Only | X | 2 | Inflammation, Chronic Active | | 2 1.5| Transitional Epithelium, Hyperplasia | | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 32 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 4| 7| 6| 6| DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 9| 2| 3| 8| 2| 5| 5| | 0| 0| 0| 3| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 0| 1| 1| 5| 8| 0| 1| 2| 2| 6| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + A A A + +| __________________________________________________________________________| Intestine Large | + + + A + +| __________________________________________________________________________| Intestine Large, Cecum | + A + A + A| __________________________________________________________________________| Intestine Large, Colon | + + A A + +| __________________________________________________________________________| Intestine Large, Rectum | + A A A + A| __________________________________________________________________________| Intestine Small | + + A A A + +| __________________________________________________________________________| Intestine Small, Duodenum | + A A A + +| __________________________________________________________________________| Intestine Small, Ileum | + A A A + A| Lymphoid Nodule, Hyperplasia | | __________________________________________________________________________| Intestine Small, Jejunum | + + A A A + A| Lymphoid Nodule, Hyperplasia | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Cyst | | Hemorrhage | 3| Necrosis | 2 3 | __________________________________________________________________________| Mesentery | + + + | Fat, Mineralization | | Fat, Necrosis | 4 4 4 | __________________________________________________________________________| Pancreas | + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + A + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + A + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + A + +| Acanthosis | | Hyperkeratosis | | Inflammation, Chronic Active | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + A A + +| Inflammation, Chronic Active | 2 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + +| Capsule, Hyperplasia | 1 2 1 2 1 1 1 1 1 2| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + +| Hyperplasia | 2| Hypertrophy | 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M + M M M +| __________________________________________________________________________| Pituitary Gland | + M + + + +| _____________________________________________________________________________________________________________________| Page 33 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 4| 7| 6| 6| DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 9| 2| 3| 8| 2| 5| 5| | 0| 0| 0| 3| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 0| 1| 1| 5| 8| 0| 1| 2| 2| 6| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Thyroid Gland | + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + +| __________________________________________________________________________| Penis | +| __________________________________________________________________________| Preputial Gland | + + + + + + + | Dilatation | 3 3 3 | Inflammation, Chronic Active | 2 1 | Mineralization | | Necrosis | 3 2 | __________________________________________________________________________| Prostate | + + + A + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + A + +| __________________________________________________________________________| Testes | + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + A + + + +| Iliac, Cyst | | Mediastinal, Hematopoietic Cell | | Proliferation | 2 | Mediastinal, Infiltration Cellular, | | Plasma Cell | 2 | Mediastinal, Infiltration Cellular, | | Histiocyte | 2 | Pancreatic, Angiectasis | | __________________________________________________________________________| Lymph Node, Mandibular | + M M M M M| __________________________________________________________________________| Lymph Node, Mesenteric | + + + M + + + + + + A + + + +| Angiectasis | 1 3 1 3 2 2 2 2 1 2 2| Hematopoietic Cell Proliferation | 1 3 2 2 2 2 2| Hyperplasia, Lymphoid | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + +| Atrophy | 4 | Hematopoietic Cell Proliferation | 3 3 4 2 3 2 3 | Hemorrhage | 2 | __________________________________________________________________________| Thymus | + + + M A + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M| __________________________________________________________________________| Skin | M + + + + + + + + + + + +| Inflammation, Acute | 2 | Necrosis | | _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 4| 7| 6| 6| DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 9| 2| 3| 8| 2| 5| 5| | 0| 0| 0| 3| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 0| 1| 1| 5| 8| 0| 1| 2| 2| 6| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Prepuce, Hemorrhage | 2| Prepuce, Inflammation, Acute | 1 | Prepuce, Inflammation, Chronic Active| | Prepuce, Necrosis | | Subcutaneous Tissue, Necrosis | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + +| Joint, Hyperostosis | 2 | Tarsal, Hyperostosis | 2 2 3 3 3 3 2 3 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + +| Congestion | 2 | Hemorrhage | | Infiltration Cellular, Histiocyte | 2 1 | Alveolar Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Nose | + + + + M +| __________________________________________________________________________| Trachea | + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + +| Casts Protein | 1 | Cortex, Mineralization | 2 1 | Papilla, Mineralization | 1 | Renal Tubule, Regeneration | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + A + +| Calculus Gross Observation | X X | Calculus Micro Observation Only | X X X | _____________________________________________________________________________________________________________________| Page 35 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 5| 0| 6| 3| 3| 3| 3| 3| | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 5| 0| 9| 1| 1| 1| 1| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + | 10 | __________________________________________________________________________|____________| Gallbladder | + + A | 10 | __________________________________________________________________________|____________| Intestine Large | + + + | 8 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + A | 5 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + | 7 | __________________________________________________________________________|____________| Intestine Large, Rectum | + M A | 3 | __________________________________________________________________________|____________| Intestine Small | + + + + + + A | 10 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + A | 5 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + A | 6 | Lymphoid Nodule, Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + A | 7 | Lymphoid Nodule, Hyperplasia | 3 3 | 2 3.0| __________________________________________________________________________|____________| Liver | + + + + + + + | 24 | Angiectasis | 2 | 2 2.0| Cyst | X | 1 | Hemorrhage | | 1 3.0| Necrosis | 1 | 3 2.0| __________________________________________________________________________|____________| Mesentery | + | 4 | Fat, Mineralization | 3 | 1 3.0| Fat, Necrosis | 4 | 4 4.0| __________________________________________________________________________|____________| Pancreas | + + + + + | 13 | __________________________________________________________________________|____________| Salivary Glands | + + + + | 9 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acanthosis | 2 | 1 2.0| Hyperkeratosis | 2 2 1 1 | 4 1.5| Inflammation, Chronic Active | 1 | 1 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Inflammation, Chronic Active | 1 2 2 2 | 6 1.7| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + | 9 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + | 13 | Capsule, Hyperplasia | 1 2 1 | 13 1.3| __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + | 13 | Hyperplasia | | 1 2.0| Hypertrophy | 2 | 2 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 36 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 5| 0| 6| 3| 3| 3| 3| 3| | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 5| 0| 9| 1| 1| 1| 1| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + | 13 | Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + | 13 | __________________________________________________________________________|____________| Parathyroid Gland | M + M | 3 | __________________________________________________________________________|____________| Pituitary Gland | + + + | 8 | __________________________________________________________________________|____________| Thyroid Gland | + + M | 8 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + | 9 | __________________________________________________________________________|____________| Penis | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + | 19 | Dilatation | 2 2 | 5 2.6| Inflammation, Chronic Active | 2 2 3 2 | 6 2.0| Mineralization | 1 | 1 1.0| Necrosis | 2 2 3 2 | 6 2.3| __________________________________________________________________________|____________| Prostate | + + + | 8 | __________________________________________________________________________|____________| Seminal Vesicle | + + + | 11 | __________________________________________________________________________|____________| Testes | + + + | 9 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + | 9 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + M | 23 | Iliac, Cyst | X | 1 | Mediastinal, Hematopoietic Cell | | | Proliferation | | 1 2.0| Mediastinal, Infiltration Cellular, | | | Plasma Cell | | 1 2.0| Mediastinal, Infiltration Cellular, | | | Histiocyte | | 1 2.0| Pancreatic, Angiectasis | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + M | 3 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + M | 22 | Angiectasis | 2 2 1 2 4 3 2 | 18 2.1| Hematopoietic Cell Proliferation | 1 2 2 | 10 1.9| Hyperplasia, Lymphoid | | 1 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + +| 26 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 37 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 5| 0| 6| 3| 3| 3| 3| 3| | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 5| 0| 9| 1| 1| 1| 1| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Atrophy | | 1 4.0| Hematopoietic Cell Proliferation | 2 2 2 2 2 | 12 2.5| Hemorrhage | 2 | 2 2.0| __________________________________________________________________________|____________| Thymus | + + M | 7 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 22 | Inflammation, Acute | | 1 2.0| Necrosis | 1 2 2 | 3 1.7| Prepuce, Hemorrhage | | 1 2.0| Prepuce, Inflammation, Acute | 2 | 2 1.5| Prepuce, Inflammation, Chronic Active| 3 | 1 3.0| Prepuce, Necrosis | 2 2 | 2 2.0| Subcutaneous Tissue, Necrosis | | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + | 31 | Joint, Hyperostosis | 3 | 2 2.5| Tarsal, Hyperostosis | 3 4 2 3 4 3 2 4 4 1 1 1 3 | 21 2.7| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + | 9 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + | 17 | Congestion | | 1 2.0| Hemorrhage | 2 | 1 2.0| Infiltration Cellular, Histiocyte | 1 | 3 1.3| Alveolar Epithelium, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Nose | + + M | 7 | __________________________________________________________________________|____________| Trachea | + + + + + + | 17 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + | 13 | Casts Protein | | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 38 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 5| 0| 6| 3| 3| 3| 3| 3| | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 5| 0| 9| 1| 1| 1| 1| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Cortex, Mineralization | 1 | 3 1.3| Papilla, Mineralization | | 1 1.0| Renal Tubule, Regeneration | | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + | 15 | Calculus Gross Observation | X X | 4 | Calculus Micro Observation Only | X X | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 39 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 0| 7| 7| 7| 6| DAY ON TEST | 2| 2| 5| 1| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| | 9| 9| 2| 4| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 9| 0| 0| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Gallbladder | + + A + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Large | + + A + + + + + + + + + + + + + + + + + M + + + +| Anus, Necrosis | | __________________________________________________________________________| Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Intestine Small | + + A + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + M + + + +| Lymphoid Nodule, Hyperplasia | | __________________________________________________________________________| Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + M + + + +| Lymphoid Nodule, Hyperplasia | | __________________________________________________________________________| Liver | + + A + + + + + + + + + + + + + + + + + + + + + +| Clear Cell Focus | | Cyst | | Fibrosis | 1 | Mixed Cell Focus | | Necrosis | 1 3 | __________________________________________________________________________| Mesentery | | Fat, Mineralization | | Fat, Necrosis | | __________________________________________________________________________| Pancreas | + + M + + + + + + + + + + + + + + + + + M + + + +| Acinus, Atrophy | 1 | __________________________________________________________________________| Salivary Glands | + + A + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + M + + + + + + + M + + + +| Hyperkeratosis | 1 1 | __________________________________________________________________________| Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + M + + + +| Hyperplasia | | Inflammation, Chronic Active | 1 1 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| Capsule, Hyperplasia | 1 1 1 1 1 2 2 1 1 2 2 2 1 1 1 1 1 1 1 1 1 1 1| __________________________________________________________________________| Adrenal Gland, Cortex | + + M + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | | Hyperplasia | 1 1 | Hypertrophy | 1 2 1 1 1 | __________________________________________________________________________| Adrenal Gland, Medulla | + + M + + + + + + + + + + + + + + + + + + + + + M| Hyperplasia | 1 1 1 | _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 0| 7| 7| 7| 6| DAY ON TEST | 2| 2| 5| 1| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| | 9| 9| 2| 4| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 9| 0| 0| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Islets, Pancreatic | + + M + + + + + + + + M + + + + + + + + M + + + +| __________________________________________________________________________| Parathyroid Gland | M + M + + M + + + M M + + + + M + + M + M + M M M| __________________________________________________________________________| Pituitary Gland | + M + + + + + + + + + M + + + + + + + + + + + + +| Pars Distalis, Cyst | X X X X | Pars Intermedia, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + M + + + + + + + + + + + + + + + + + M + + + M| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + A + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + +| Atrophy | 2 | Dilatation | 3 3 3 2| Inflammation, Acute | 3 | Inflammation, Chronic Active | 1 | Necrosis | 3 | __________________________________________________________________________| Prostate | + + A + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2| __________________________________________________________________________| Seminal Vesicle | + + A + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + A + + + + + + + + + + + + + + + + + + + + + +| Seminiferous Tubule, Atrophy | 1 | Seminiferous Tubule, Mineralization | 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + M + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + M M M M + M + + + + + + M + M M + M M + M + +| Hematopoietic Cell Proliferation | | __________________________________________________________________________| Lymph Node, Mesenteric | + + M + + + M + + + + + + + + + + + + + M + + + +| Angiectasis | 2 2 2 2 3 1 3 1 2 2 2 3 1 3 3| Hematopoietic Cell Proliferation | 2 1 2 1 2 2 2 2 2 1 2 1 3| Hemorrhage | 1 | __________________________________________________________________________| Spleen | + + M + + + + + + + + + + + + + + + + + M + + + +| Angiectasis | | Depletion Lymphoid | 3| Fibrosis | 2 | Hematopoietic Cell Proliferation | 2 2 2 3 1 1 1 1 2 1 2 3 2 1 2 1 1 | __________________________________________________________________________| Thymus | + + M + + + + + + + + + + + + + + + M + M + + + +| Depletion Lymphoid | 3| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M + + M M M M + M + M M M M + M + M M M| _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 0| 7| 7| 7| 6| DAY ON TEST | 2| 2| 5| 1| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| | 9| 9| 2| 4| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 9| 0| 0| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Skin | + + + + + M + + + + + + + + + + + + + M M + + + +| Acanthosis | 2 | Hyperkeratosis | | Inflammation, Acute | | Mineralization | | Necrosis | 3 1 | Prepuce, Fibrosis | | Prepuce, Necrosis | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Tarsal, Hyperostosis | 2 2 2 3 2 3 2 2 3 1| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 3 | Hemorrhage | 1 | Infiltration Cellular, Histiocyte | 2 | Inflammation, Chronic Active | | Alveolar Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + + | Hyperplasia | 1 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + A + + + + + + + + + + + + + + + + + + + + + +| Casts Protein | 1 | Congestion | 1 | Inflammation, Acute | 3| Cortex, Mineralization | 1 1 1 1 | Papilla, Mineralization | | Papilla, Necrosis | 1| __________________________________________________________________________| Urinary Bladder | + + A + + + + + + + + + + + + + + + + + M + + + +| Angiectasis | 2 | _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 0| 7| 7| 7| 6| DAY ON TEST | 2| 2| 5| 1| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| | 9| 9| 2| 4| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 9| 0| 0| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Calculus Gross Observation | X | Calculus Micro Observation Only | X X X | Inflammation, Chronic Active | 2| Mineralization | 1| _____________________________________________________________________________________________________________________| Page 43 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 9| 6| 3| 3| 3| 3| 8| 3| 3| 3| 3| 8| 8| 3| 3| 3| 1| | | 0| 0| 0| 0| 0| 0| 0| 0| 4| 4| 0| 0| 0| 0| 2| 0| 0| 0| 0| 2| 2| 0| 0| 0| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + M + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | Anus, Necrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + M + + + + + + + A + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | Lymphoid Nodule, Hyperplasia | 3 3 3 | 3 3.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | Lymphoid Nodule, Hyperplasia | 2 2 | 2 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Clear Cell Focus | X | 1 | Cyst | X X | 2 | Fibrosis | | 1 1.0| Mixed Cell Focus | X X | 2 | Necrosis | | 2 2.0| __________________________________________________________________________|____________| Mesentery | + + | 2 | Fat, Mineralization | 2 | 1 2.0| Fat, Necrosis | 3 3 | 2 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | Acinus, Atrophy | | 1 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + A + M + + + + + + + +| 46 | Hyperkeratosis | | 2 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | Hyperplasia | 1 | 1 1.0| Inflammation, Chronic Active | 1 1 1 | 6 1.2| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 | Capsule, Hyperplasia | 1 2 4 1 1 2 2 1 1 1 1 2 1 1 1 3 2 1 1 2 1 1| 45 1.4| __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 44 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 9| 6| 3| 3| 3| 3| 8| 3| 3| 3| 3| 8| 8| 3| 3| 3| 1| | | 0| 0| 0| 0| 0| 0| 0| 0| 4| 4| 0| 0| 0| 0| 2| 0| 0| 0| 0| 2| 2| 0| 0| 0| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Accessory Adrenal Cortical Nodule | X | 1 | Hyperplasia | 2 2 2 1| 6 1.5| Hypertrophy | 1 1 1 2 1 3 1 3 | 13 1.5| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + M + + + + + + + + + +| 47 | Hyperplasia | 1 1 1 1 1| 8 1.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + A + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Parathyroid Gland | M M M M + + + + + M M + + + M + M M M + + M M + +| 27 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Pars Distalis, Cyst | X | 5 | Pars Intermedia, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + A + + + + + + + + + +| 46 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 18 | Atrophy | | 1 2.0| Dilatation | 3 2 3 3 3 | 9 2.8| Inflammation, Acute | | 1 3.0| Inflammation, Chronic Active | 1 1 | 3 1.0| Necrosis | 3 2 2 1 | 5 2.2| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 | Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Seminiferous Tubule, Atrophy | | 1 1.0| Seminiferous Tubule, Mineralization | | 1 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + M + + + + M M M + M A M M M + + + + M M +| 28 | Hematopoietic Cell Proliferation | 1 | 1 1.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + A + + + + + + + + + M| 45 | Angiectasis | 3 2 2 2 2 3 1 1 1 | 24 2.0| Hematopoietic Cell Proliferation | 2 2 2 2 1 2 1 | 20 1.8| Hemorrhage | | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 45 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 9| 6| 3| 3| 3| 3| 8| 3| 3| 3| 3| 8| 8| 3| 3| 3| 1| | | 0| 0| 0| 0| 0| 0| 0| 0| 4| 4| 0| 0| 0| 0| 2| 0| 0| 0| 0| 2| 2| 0| 0| 0| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | Angiectasis | 1 | 1 1.0| Depletion Lymphoid | | 1 3.0| Fibrosis | | 1 2.0| Hematopoietic Cell Proliferation | 1 2 2 3 1 1 2 2 2 1 2 2 2 1 2 2 1 2 3| 36 1.7| __________________________________________________________________________|____________| Thymus | M + + + + + + + + + + + + + M + M M + + + + + M +| 42 | Depletion Lymphoid | | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M + M M + + M M M M M M M M M M M M M M| 9 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Acanthosis | | 1 2.0| Hyperkeratosis | 2| 1 2.0| Inflammation, Acute | 2 | 1 2.0| Mineralization | 3| 1 3.0| Necrosis | 2 3 | 4 2.3| Prepuce, Fibrosis | 2 | 1 2.0| Prepuce, Necrosis | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Tarsal, Hyperostosis | 2 2 1 2 1 2 3 4 1 2 1 1 3 2 2| 25 2.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 2 1 2 | 4 1.8| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 2 2| 4 2.3| Hemorrhage | 1 1 2 | 4 1.3| Infiltration Cellular, Histiocyte | 3 2 | 3 2.3| Inflammation, Chronic Active | 2| 1 2.0| Alveolar Epithelium, Hyperplasia | 2 1 | 3 1.7| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + A + + + + + + + + + M| 48 | Inflammation, Acute | 1 | 1 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 46 NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 13:22:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 9| 6| 3| 3| 3| 3| 8| 3| 3| 3| 3| 8| 8| 3| 3| 3| 1| | | 0| 0| 0| 0| 0| 0| 0| 0| 4| 4| 0| 0| 0| 0| 2| 0| 0| 0| 0| 2| 2| 0| 0| 0| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Ear | | 1 | __________________________________________________________________________|____________| Eye | | 1 | __________________________________________________________________________|____________| Harderian Gland | + + + | 5 | Hyperplasia | | 1 1.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Casts Protein | | 1 1.0| Congestion | 2 | 2 1.5| Inflammation, Acute | | 1 3.0| Cortex, Mineralization | 1 1 1 1| 8 1.0| Papilla, Mineralization | 1 | 1 1.0| Papilla, Necrosis | | 1 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | Angiectasis | | 1 2.0| Calculus Gross Observation | X | 2 | Calculus Micro Observation Only | X X X X X | 8 | Inflammation, Chronic Active | | 1 2.0| Mineralization | | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 47 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------ --multipart-boundary Content-type: text/plain Range: bytes 438443-438443/438443 --multipart-boundary--