TR 365 Mouse Pathology Tables
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
Facility: TSI Mason Research
Chemical CAS #: 78-11-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9|
| 3| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + M + + + +|
Lymphoid Nodule, Mineralization | 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | |
Fatty Change, Diffuse | |
Fatty Change, Focal | |
Fibrosis | 2 |
Mineralization | |
Necrosis | 1 1 2|
Pigmentation | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Acinus, Atrophy | 2 1 |
Acinus, Hypertrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | 2 1 2 2 |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 |
Mineralization | 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Capsule, Hyperplasia | 2 1 2 2 2 2 2 2 2 2 2 1 1 2 1 2 1 2 2 1 1 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9|
| 3| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 1 2 2 2 2 2 2 2 2 1 1 2 1 2 1 2 1 2|
Hypertrophy | 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + M + M + + M M + + + M M + + + + + M M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
Pars Distalis, Angiectasis | 1 |
Pars Distalis, Hyperplasia | 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
Degeneration, Cystic | |
Hemorrhage | |
Hyperplasia, Papillary | |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Inflammation, Chronic Active | 3 2 |
Endometrium, Hyperplasia | 2 1 1 1 2 2 2 2 2 2 2 2 2 2 3 3 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + M + + + + + + + + +|
Myelofibrosis | 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Angiectasis | |
Mediastinal, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + M + + + + M + + + + + + + + M + + M + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9|
| 3| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 2 1 2 2 1 1 1 1 2 1 1 1 1 1 1 1 |
Lymphoid Follicle, Hyperplasia | 2 3 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Acinus, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 2 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | 1 |
Hemorrhage | 1 1 |
Infiltration Cellular, Histiocyte | 1 |
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + M + M + + + + + + M + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 6| 3| 7| 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 2| 9| 3| 3| 5| 3| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 4| 3| 3| 3| 1| 8| |
| 2| 2| 3| 9| 4| 3| 2| 4| 7| 8| 2| 2| 2| 9| 2| 2| 2| 2| 2| 8| 2| 2| 3| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + M + + + + + + + + + + + + + + M + + + + + +| 47 |
__________________________________________________________________________|____________|
Gallbladder | + + + A A + + + + A + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + M + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + M + + M M + + + + + + + + + M + + + M +| 45 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + M + A + + + + + M + + + + + + + + + + + + + + +| 46 |
Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + M + + + + + + + + + + + + + + + +| 47 |
Lymphoid Nodule, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A A + + + + + + + + + + + + + + + + + + M +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | X | 1 |
Clear Cell Focus | X | 1 |
Fatty Change, Diffuse | 2 2 | 2 2.0|
Fatty Change, Focal | 1 | 1 1.0|
Fibrosis | | 1 2.0|
Mineralization | 1 | 1 1.0|
Necrosis | 1 3 3 | 6 1.8|
Pigmentation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 3 2 | 2 2.5|
Acinus, Atrophy | | 2 1.5|
Acinus, Hypertrophy | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 2 | 2 2.0|
Hyperkeratosis | 1 1 1 1 2 2 1| 11 1.5|
Inflammation, Chronic Active | 1| 2 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + + + M + + + + A + + + + + + + + + + +| 47 |
Inflammation, Chronic Active | 1 | 3 1.0|
Mineralization | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 | 1 2.0|
Thrombosis | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 6| 3| 7| 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 2| 9| 3| 3| 5| 3| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 4| 3| 3| 3| 1| 8| |
| 2| 2| 3| 9| 4| 3| 2| 4| 7| 8| 2| 2| 2| 9| 2| 2| 2| 2| 2| 8| 2| 2| 3| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Capsule, Hyperplasia | 2 2 1 1 1 2 2 2 2 2 1 2 2 1 2 2 2 1| 40 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia | 2 2 1 1 2 2 2 2 2 1 2 1 2 2 2 2 1| 36 1.7|
Hypertrophy | 1 | 3 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + M + M + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + A M + + + + + + + M + M + + + M + M M + + +| 32 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + M + + M + + + + + + + + + + + M M +| 45 |
Pars Distalis, Angiectasis | 1 1 2 | 4 1.3|
Pars Distalis, Hyperplasia | 1 1 2 1 2 1| 8 1.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + M + + + + + + + + + + + + + + M + + + + + +| 47 |
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X X X | 9 |
Degeneration, Cystic | 2 | 1 2.0|
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Papillary | 1 | 1 1.0|
__________________________________________________________________________|____________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + I + + +| 49 |
Angiectasis | 2 | 2 1.5|
Inflammation, Chronic Active | 2 | 3 2.3|
Endometrium, Hyperplasia | 2 1 2 2 1 2 2 2 2 2 1 2 2 2 1| 36 1.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Myelofibrosis | 2 1 | 5 1.8|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 6| 3| 7| 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 2| 9| 3| 3| 5| 3| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 4| 3| 3| 3| 1| 8| |
| 2| 2| 3| 9| 4| 3| 2| 4| 7| 8| 2| 2| 2| 9| 2| 2| 2| 2| 2| 8| 2| 2| 3| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lumbar, Angiectasis | 3 | 1 3.0|
Mediastinal, Angiectasis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M M + M + + + + + + + M + + + + + M + + +| 40 |
Hematopoietic Cell Proliferation | 2 1 | 2 1.5|
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
Angiectasis | 1 2 | 3 1.3|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Hematopoietic Cell Proliferation | 1 1 1 2 3 2 1 1 1 2 2 1 1 2 2 1 1 1 1| 35 1.3|
Lymphoid Follicle, Hyperplasia | 2 | 4 2.3|
__________________________________________________________________________|____________|
Thymus | + + + A M + + M M + + + + M + + + M + + + + + + +| 42 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M M + M M + M M M M + M + + + M +| 39 |
Acinus, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 1 | 5 1.4|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 1 2.0|
Edema | 2 | 2 1.5|
Hemorrhage | 1 2 1 1 | 6 1.2|
Infiltration Cellular, Histiocyte | 2 1 | 3 1.3|
Inflammation, Chronic Active | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + M + M + + + + + + + + + + + + + M + + + + + M +| 43 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 6| 3| 7| 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 2| 9| 3| 3| 5| 3| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 4| 3| 3| 3| 1| 8| |
| 2| 2| 3| 9| 4| 3| 2| 4| 7| 8| 2| 2| 2| 9| 2| 2| 2| 2| 2| 8| 2| 2| 3| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + + + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + A + + + + + + + + + A + + + + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 0| 7| 7| 7| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 8| 7| 3| 3| 3| 3| 7| 3| 3| 1| 6| 8|
| 1| 1| 1| 1| 0| 5| 1| 1| 1| 1| 1| 1| 1| 8| 9| 1| 1| 1| 1| 4| 1| 1| 8| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A + + + A + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large | + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + M + + +|
Lymphoid Nodule, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A A + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X |
Fatty Change, Diffuse | 1 |
Fatty Change, Focal | 1 1 |
Hematopoietic Cell Proliferation | 2 2 3 2 2 |
Hemorrhage | |
Necrosis | 1 2 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Acute | 2 3 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + +|
Cyst | |
Acinus, Atrophy | 1 |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 |
Hyperkeratosis | 2 2 1 2 |
Necrosis | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic Active | 1 |
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 0| 7| 7| 7| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 8| 7| 3| 3| 3| 3| 7| 3| 3| 1| 6| 8|
| 1| 1| 1| 1| 0| 5| 1| 1| 1| 1| 1| 1| 1| 8| 9| 1| 1| 1| 1| 4| 1| 1| 8| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Capsule, Hyperplasia | 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + +|
Hyperplasia | 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hyperplasia | 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + +|
Abscess | 4 4 |
Cyst | X |
Degeneration, Cystic | 2 4 3 3 3|
Hemorrhage | 3 |
Bilateral, Abscess | 4 |
__________________________________________________________________________|
Oviduct | + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Angiectasis | 2 |
Hemorrhage | |
Inflammation, Chronic Active | 2 1 |
Pigmentation | |
Endometrium, Hyperplasia | 2 3 3 2 3 3 2 3 3 3 2 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + +|
Axillary, Hematopoietic Cell | |
Proliferation | 1 |
Axillary, Infiltration Cellular, | |
Plasma Cell | 2 |
Lumbar, Hematopoietic Cell | |
Proliferation | 2 |
Lumbar, Infiltration Cellular, | |
Plasma Cell | 2 |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 2 3 |
Renal, Hematopoietic Cell | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 0| 7| 7| 7| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 8| 7| 3| 3| 3| 3| 7| 3| 3| 1| 6| 8|
| 1| 1| 1| 1| 0| 5| 1| 1| 1| 1| 1| 1| 1| 8| 9| 1| 1| 1| 1| 4| 1| 1| 8| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Proliferation | 2 |
Renal, Infiltration Cellular, Plasma | |
Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + +|
Hematopoietic Cell Proliferation | 2 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + M M + + + +|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 2 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 3 3 1 3 3 2 2 2 2 3|
Lymphoid Follicle, Hyperplasia | 2 3 |
__________________________________________________________________________|
Thymus | + + M + + +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M + M +|
Necrosis | |
__________________________________________________________________________|
Skin | + + + + + + +|
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + +|
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + +|
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | |
Inflammation, Acute | |
__________________________________________________________________________|
Nose | + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Acute | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + +|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 0| 7| 7| 7| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 8| 7| 3| 3| 3| 3| 7| 3| 3| 1| 6| 8|
| 1| 1| 1| 1| 0| 5| 1| 1| 1| 1| 1| 1| 1| 8| 9| 1| 1| 1| 1| 4| 1| 1| 8| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Acute | |
Papilla, Mineralization | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + +|
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 1| 6| 2| 3| 3| 3| 3| 3| 3| 3| 9| 3| 6| 3| 3| 3| 2| 7| 3| 3| 2| 7| 2| |
| 1| 1| 4| 8| 1| 1| 1| 1| 1| 1| 2| 2| 6| 4| 8| 2| 2| 2| 8| 4| 2| 2| 8| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + +| 12 |
__________________________________________________________________________|____________|
Gallbladder | + + A A A + + + + + + + + + A + + + A + + + A +| 41 |
Inflammation, Acute | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | A + + + + +| 11 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + +| 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + +| 11 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + M + + +| 9 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A +| 15 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + A +| 11 |
Lymphoid Nodule, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A +| 11 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + A + A +| 11 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 1 |
Clear Cell Focus | X X | 3 |
Fatty Change, Diffuse | | 1 1.0|
Fatty Change, Focal | 2 1 2 | 5 1.4|
Hematopoietic Cell Proliferation | 3 | 6 2.3|
Hemorrhage | 2 | 1 2.0|
Necrosis | 1 | 3 1.3|
__________________________________________________________________________|____________|
Mesentery | + + + +| 6 |
Inflammation, Acute | 3| 3 2.7|
Fat, Necrosis | 4 3 4 | 3 3.7|
__________________________________________________________________________|____________|
Pancreas | + + M + + + + A +| 13 |
Cyst | X | 1 |
Acinus, Atrophy | 4 3 | 3 2.7|
Duct, Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | M + + + + +| 12 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 1 3 1 | 5 1.8|
Hyperkeratosis | 2 2 2 2 2 2 | 10 1.9|
Necrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 1 | 1 1.0|
Inflammation, Chronic Active | 1 2 1 | 4 1.3|
Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 1| 6| 2| 3| 3| 3| 3| 3| 3| 3| 9| 3| 6| 3| 3| 3| 2| 7| 3| 3| 2| 7| 2| |
| 1| 1| 4| 8| 1| 1| 1| 1| 1| 1| 2| 2| 6| 4| 8| 2| 2| 2| 8| 4| 2| 2| 8| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + +| 12 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + +| 12 |
Capsule, Hyperplasia | 2 2| 7 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + +| 12 |
Hyperplasia | 2 2| 7 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + M +| 11 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + M + + + + A +| 12 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + M M| 8 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + A +| 15 |
Pars Distalis, Angiectasis | 2 | 2 2.0|
Pars Distalis, Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + +| 12 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + +| 19 |
Abscess | | 2 4.0|
Cyst | X | 2 |
Degeneration, Cystic | 2 | 6 2.8|
Hemorrhage | | 1 3.0|
Bilateral, Abscess | 4| 2 4.0|
__________________________________________________________________________|____________|
Oviduct | + + | 4 |
__________________________________________________________________________|____________|
Uterus | + A + + + + + + + + + + + + + +| 37 |
Abscess | | 1 3.0|
Angiectasis | | 1 2.0|
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic Active | 2| 3 1.7|
Pigmentation | 2 | 1 2.0|
Endometrium, Hyperplasia | 2 2 3 3 2 2 | 19 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + +| 12 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + M + + +| 17 |
Axillary, Hematopoietic Cell | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 1| 6| 2| 3| 3| 3| 3| 3| 3| 3| 9| 3| 6| 3| 3| 3| 2| 7| 3| 3| 2| 7| 2| |
| 1| 1| 4| 8| 1| 1| 1| 1| 1| 1| 2| 2| 6| 4| 8| 2| 2| 2| 8| 4| 2| 2| 8| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Proliferation | | 1 1.0|
Axillary, Infiltration Cellular, | | |
Plasma Cell | | 1 2.0|
Lumbar, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
Lumbar, Infiltration Cellular, | | |
Plasma Cell | | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | | 2 2.5|
Renal, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
Renal, Infiltration Cellular, Plasma | | |
Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + M M + M| 8 |
Hematopoietic Cell Proliferation | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + A + + + M + + +| 12 |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | 2| 3 1.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 1 2 2 3 2 3| 20 2.3|
Lymphoid Follicle, Hyperplasia | 2 2 2 | 5 2.2|
__________________________________________________________________________|____________|
Thymus | + + + M + +| 10 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M M + M M| 5 |
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + +| 13 |
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + +| 12 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + +| 12 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 1| 6| 2| 3| 3| 3| 3| 3| 3| 3| 9| 3| 6| 3| 3| 3| 2| 7| 3| 3| 2| 7| 2| |
| 1| 1| 4| 8| 1| 1| 1| 1| 1| 1| 2| 2| 6| 4| 8| 2| 2| 2| 8| 4| 2| 2| 8| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + +| 16 |
Hemorrhage | | 1 1.0|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
Inflammation, Acute | 2| 1 2.0|
__________________________________________________________________________|____________|
Nose | M + + M M +| 9 |
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + +| 16 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + +| 14 |
Inflammation, Acute | 2| 1 2.0|
Papilla, Mineralization | 1 | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A +| 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 7| 0| 3| 3| 3| 8| 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 1| 0| 0| 0| 5| 5| 0| 0| 0| 9| 3| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + A + + + + + + + + + M + M + + A + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +|
Parasite | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + A + + + + + + + M + +|
__________________________________________________________________________|
Intestine Small | + + + + A + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + A + + + + A + + + + +|
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + A + + + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + A + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | |
Eosinophilic Focus | X X |
Fatty Change, Focal | 1 1 |
Necrosis | 2 2 |
Pigmentation | 2 |
Thrombosis | X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + M + + + + + + + + + +|
Fibrosis | |
Inflammation, Chronic Active | 2 |
Necrosis | |
Acinus, Atrophy | 1 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + + + + + +|
Acanthosis | 1 1 |
Edema | 1 |
Hyperkeratosis | 2 2 2 1 1 1 1 |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + A + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 2 1 2 1 2 1 1|
Mineralization | 1 |
__________________________________________________________________________|
Tooth | |
Incisor, Developmental Malformation | |
Incisor, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + A + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 7| 0| 3| 3| 3| 8| 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 1| 0| 0| 0| 5| 5| 0| 0| 0| 9| 3| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Capsule, Hyperplasia | 1 1 2 1 2 1 2 1 2 2 2 2 2 2 2 1 1 2 3 1 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia | 1 1 2 2 1 2 1 2 2 2 2 2 2 1 1 2 3 1 2|
Hypertrophy | 2 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + M + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + M + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + M + + M M M M + M + M + + M + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + M + + + + M M + + + + + M + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia | 1 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + M + + + + + + + + + M + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + M + + + + + + + + + +|
Angiectasis | 2 |
Cyst | X X X X X X |
Degeneration, Cystic | 2 |
Hemorrhage | |
Mineralization | 2 |
Necrosis | |
Pigmentation | 2 |
Thrombosis | X |
Bilateral, Abscess | |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + M + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Necrosis | 1 |
Endometrium, Hyperplasia | 2 2 2 2 3 2 2 2 3 2 2 3 2 3 2 2 3 2 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + A + + + + + + + + + +|
Myelofibrosis | 1 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Infiltration Cellular, | |
Plasma Cell | 2 |
Pancreatic, Hematopoietic Cell | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 7| 0| 3| 3| 3| 8| 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 1| 0| 0| 0| 5| 5| 0| 0| 0| 9| 3| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Proliferation | 1 |
Renal, Infiltration Cellular, Plasma | |
Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + M + + M M + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M M + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 2 1 1 2 1 2 2 2 2 1 1 1 2 1 2 2|
Hemorrhage | |
Necrosis | |
Lymphoid Follicle, Hyperplasia | |
__________________________________________________________________________|
Thymus | + + M + + + + + + + M + + + M + M + + M + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M M M + + + + + + + + M + + + + M + + M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + M + + + + + + + M + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + A + + + + + + + + + +|
Mineralization | 2 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + A + + + + + + + + + +|
Edema | 1 |
Hemorrhage | 1 2|
Alveolar Epithelium, Hyperplasia | |
Pleura, Inflammation, Acute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + A + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + A + + + + + + + + + +|
Casts | |
Cyst | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 7| 0| 3| 3| 3| 8| 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 1| 0| 0| 0| 5| 5| 0| 0| 0| 9| 3| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Glomerulosclerosis | |
Inflammation, Chronic Active | |
Papilla, Mineralization | |
Renal Tubule, Pigmentation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 0| 3| 3| 6| 4| 8| |
| 1| 1| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 4| 7| 1| 1| 3| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + M +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + A + + + M A +| 43 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + A +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + + + + + + + + + + + + + + + A + + + + + A +| 44 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + A + A + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A A A + + + A +| 43 |
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + A + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + A + + + A +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | X X | 2 |
Clear Cell Focus | X | 1 |
Eosinophilic Focus | X | 3 |
Fatty Change, Focal | | 2 1.0|
Necrosis | | 2 2.0|
Pigmentation | | 1 2.0|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis | 1 | 1 1.0|
Inflammation, Chronic Active | 3 | 2 2.5|
Necrosis | 2 2 | 2 2.0|
Acinus, Atrophy | 1 | 3 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + M +| 48 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 1 1 | 4 1.0|
Edema | | 1 1.0|
Hyperkeratosis | 1 1 2 2 1 1 | 13 1.4|
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic Active | 2 1 2 | 10 1.5|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Incisor, Developmental Malformation | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 0| 3| 3| 6| 4| 8| |
| 1| 1| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 4| 7| 1| 1| 3| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Incisor, Inflammation, Acute | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Capsule, Hyperplasia | 2 2 2 2 1 1 1 1 2 2 2 1 2 2 2 3 2 2 2 2 1 2| 43 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 2 1 1 1 1 2 2 1 2 2 2 2 2 2 2 2 1 | 38 1.7|
Hypertrophy | | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | M + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M M M + M + + + + + M + + + + M + M +| 34 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + M M + + + +| 42 |
Pars Distalis, Angiectasis | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 2 1 2 2 1 2 2 | 10 1.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 47 |
Follicular Cell, Hyperplasia | 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
Angiectasis | 3 2 | 3 2.3|
Cyst | X X X | 9 |
Degeneration, Cystic | 2 | 2 2.0|
Hemorrhage | 2 1 | 2 1.5|
Mineralization | 2 | 2 2.0|
Necrosis | 2 | 1 2.0|
Pigmentation | 2 | 2 2.0|
Thrombosis | | 1 |
Bilateral, Abscess | 3 | 1 3.0|
__________________________________________________________________________|____________|
Oviduct | + + + + + + + + + + + + + + + + + M + + + + + +| 43 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 3 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 0| 3| 3| 6| 4| 8| |
| 1| 1| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 4| 7| 1| 1| 3| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Necrosis | | 1 1.0|
Endometrium, Hyperplasia | 2 2 2 2 2 2 2 2 2 1 2 2 2 2 1 2 3 | 38 2.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Myelofibrosis | 2 1 | 4 1.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + M + + + + M +| 48 |
Lumbar, Infiltration Cellular, | | |
Plasma Cell | | 1 2.0|
Pancreatic, Hematopoietic Cell | | |
Proliferation | | 1 1.0|
Renal, Infiltration Cellular, Plasma | | |
Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M M + + + M M +| 42 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M + + + + M +| 46 |
Angiectasis | 1 | 1 1.0|
Hematopoietic Cell Proliferation | 1 3 | 3 1.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 2 2 2 1 3 3 1 3| 34 1.5|
Hemorrhage | 2 | 1 2.0|
Necrosis | 4 | 1 4.0|
Lymphoid Follicle, Hyperplasia | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + M + + + M + + + + M M +| 40 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + M M M M + M + M + + + + + + + + + + M + M| 34 |
__________________________________________________________________________|____________|
Skin | + M + + + + M + + + + + + + + + + + + + + + + + +| 46 |
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | | 2 1.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 0| 3| 3| 6| 4| 8| |
| 1| 1| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 4| 7| 1| 1| 3| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Edema | | 1 1.0|
Hemorrhage | 1 | 3 1.3|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
Pleura, Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + M + + + + + + + + + + + + M + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Casts | 2 | 1 2.0|
Cyst | X X | 2 |
Glomerulosclerosis | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Papilla, Mineralization | 1 | 1 1.0|
Renal Tubule, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 2| 2| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 3| 8| 8| 3| 3| 4| 0| 8| 3| 3| 3| 3| 2| 3| 3| 3| 6| 5| 3| 1| 6| 6| 0|
| 1| 1| 1| 2| 2| 1| 2| 7| 7| 4| 1| 1| 1| 2| 7| 1| 1| 1| 7| 0| 2| 5| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + A M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + M A A + + + + A + + + + + + A + A +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A M + + + + A + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M A M + + + + A + + + + M + A + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + A + + + + + A + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + M A + + + + + A + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A M + + + + A + + + + + + A + + +|
Lymphoid Nodule, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A M + + + + A + + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Eosinophilic Focus | |
Fatty Change, Diffuse | |
Fatty Change, Focal | 1 2 1 2|
Hematopoietic Cell Proliferation | |
Infarct | 3 |
Mineralization | 2 |
Mixed Cell Focus | |
Necrosis | |
Pigmentation | 2 |
Bile Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Acute | |
Fat, Mineralization | |
Fat, Necrosis | 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + M + + + + + + + + + + + + + + + +|
Acinus, Necrosis | |
Artery, Necrosis, Fibrinoid | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + A + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Stomach | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + A + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation, Chronic Active | 2 |
Mineralization | |
__________________________________________________________________________|
Tooth | + |
Incisor, Developmental Malformation | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 2| 2| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 3| 8| 8| 3| 3| 4| 0| 8| 3| 3| 3| 3| 2| 3| 3| 3| 6| 5| 3| 1| 6| 6| 0|
| 1| 1| 1| 2| 2| 1| 2| 7| 7| 4| 1| 1| 1| 2| 7| 1| 1| 1| 7| 0| 2| 5| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + A + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 1 1 1 2 1 1 1 1 1 1 1 2 1 2 1 1 1 1|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + M + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hyperplasia | 2 2 2 |
Hypertrophy | 1 1 1 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia | 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + M + M M + + M + + + + M + + M M + M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + M + + + + + + + + + + +|
Pars Intermedia, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + M + + + + + M + + + + + + + + + +|
Follicle, Cyst | 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + M + + + + + + M|
Dilatation | 2 2 2 2 2 |
Inflammation, Chronic Active | 1 2 2 1 |
Mineralization | |
Necrosis | 3 1 |
__________________________________________________________________________|
Prostate | + + M + + M + M A + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + A + + + + + + + + + + + + + + + +|
Bacterium | 2 |
Concretion | 2 |
Fibrosis | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Necrosis, Fibrinoid | |
Seminiferous Tubule, Atrophy | 1 2 |
Seminiferous Tubule, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + M M + + + + + + + + + + + + + + + +|
Axillary, Angiectasis | 2 |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 2| 2| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 3| 8| 8| 3| 3| 4| 0| 8| 3| 3| 3| 3| 2| 3| 3| 3| 6| 5| 3| 1| 6| 6| 0|
| 1| 1| 1| 2| 2| 1| 2| 7| 7| 4| 1| 1| 1| 2| 7| 1| 1| 1| 7| 0| 2| 5| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Axillary, Infiltration Cellular, | |
Lymphocyte | 2 |
Lumbar, Hematopoietic Cell | |
Proliferation | |
Renal, Hematopoietic Cell | |
Proliferation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M M + + M M M M + M + M + + M + M M M + + M M +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M M M + + + + + + + + + + + + + + +|
Angiectasis | 1 2 2 2 1 2 1 1 2 2 2 1|
Hematopoietic Cell Proliferation | 1 1 1 1 2 2 2 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + A + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 2 1 1 1 1 2 3 1 2 2 1 1 1 1 3 2 1 3 2 |
__________________________________________________________________________|
Thymus | + + + + + M + + M + + + + + M + + M + + + + M + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M M M M M M M M M M M M M M M M M M + M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hemorrhage | 2 |
Necrosis | 2 1 2 |
Prepuce, Hemorrhage | 2 |
Prepuce, Inflammation, Acute | 3 |
Prepuce, Necrosis | 4 4 |
Scrotal, Epithelium, Hyperplasia, | |
Basal Cell | 2 |
Subcutaneous Tissue, Mineralization | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Tarsal, Hyperostosis | 2 1 2 2 3 2 3 3 2 2 3 3 3 3 4|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + A + + + + + + + + + + + + + + + +|
Atelectasis | |
Congestion | 2 1 |
Edema | |
Hemorrhage | 1 1 |
Infiltration Cellular, Histiocyte | 1 1 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 2| 2| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 3| 8| 8| 3| 3| 4| 0| 8| 3| 3| 3| 3| 2| 3| 3| 3| 6| 5| 3| 1| 6| 6| 0|
| 1| 1| 1| 2| 2| 1| 2| 7| 7| 4| 1| 1| 1| 2| 7| 1| 1| 1| 7| 0| 2| 5| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic Active | 2 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + M + + M + + + M + + + + + + M M +|
Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + A + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + A + + + + + + + + + + + + + + + +|
Congestion | 2 |
Cyst | X |
Fibrosis | 1 |
Inflammation, Acute | 2 |
Cortex, Mineralization | 1 1 2 2 1 1 1 1 |
Papilla, Mineralization | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + A + + + + + A + + + + + + A + + +|
Calculus Micro Observation Only | X |
Inflammation, Chronic Active | 1 2 |
Transitional Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 5| 4| 7| 7| 7| 6| 0| 7| 5| 4| 7| 7| 6| 5| 4| 7| |
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 8| 6| 5| 3| 3| 3| 2| 2| 3| 7| 5| 3| 1| 0| 4| 1| 3| |
| 1| 1| 1| 1| 5| 2| 2| 2| 5| 4| 6| 2| 2| 2| 3| 6| 2| 8| 6| 2| 7| 0| 3| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + M + + + + + + + + A + M + + + + + + + M + + +| 43 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + A + + + + + + + + + + + M +| 41 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + A + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + M + + + A + + + + + + M + + + + + +| 40 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + A + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + +| 44 |
Lymphoid Nodule, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Cyst | X | 1 |
Eosinophilic Focus | X | 1 |
Fatty Change, Diffuse | 2| 1 2.0|
Fatty Change, Focal | 1 1 | 6 1.3|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Infarct | | 1 3.0|
Mineralization | | 1 2.0|
Mixed Cell Focus | X | 1 |
Necrosis | 3 2| 2 2.5|
Pigmentation | | 1 2.0|
Bile Duct, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Inflammation, Acute | 3 | 1 3.0|
Fat, Mineralization | 1 | 1 1.0|
Fat, Necrosis | 3 | 3 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + A + + + + + + + + + + + + +| 47 |
Acinus, Necrosis | 1 | 1 1.0|
Artery, Necrosis, Fibrinoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + A + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + A + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + A + + + + + + + + + + + + +| 47 |
Acanthosis | 1 1 2| 3 1.3|
Hyperkeratosis | 2 2| 3 1.7|
Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + A + + + + + + + + + + + + +| 47 |
Hyperplasia | | 1 1.0|
Inflammation, Chronic Active | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 5| 4| 7| 7| 7| 6| 0| 7| 5| 4| 7| 7| 6| 5| 4| 7| |
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 8| 6| 5| 3| 3| 3| 2| 2| 3| 7| 5| 3| 1| 0| 4| 1| 3| |
| 1| 1| 1| 1| 5| 2| 2| 2| 5| 4| 6| 2| 2| 2| 3| 6| 2| 8| 6| 2| 7| 0| 3| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Incisor, Developmental Malformation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + M + A + + + + + + + + + + + + +| 46 |
Capsule, Hyperplasia | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 2 1 1 1| 37 1.2|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + M + A + + + + + + + + + + + + +| 46 |
Accessory Adrenal Cortical Nodule | X | 1 |
Hyperplasia | | 3 2.0|
Hypertrophy | 1 1 | 7 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + M + A + + + + + + + + + + M + +| 45 |
Hyperplasia | 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + A + + + + + + + + + + + + +| 47 |
Hyperplasia | 2 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + A + + + M + + M + M + M + M| 32 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + A + + + + + M + + + + + + +| 45 |
Pars Intermedia, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + A + + + + + + + + + + + + +| 46 |
Follicle, Cyst | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + | 19 |
Dilatation | 2 2 3 | 8 2.1|
Inflammation, Chronic Active | 2 1 1 | 7 1.4|
Mineralization | 2 | 1 2.0|
Necrosis | 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + A + + + + + + + + + + + M +| 43 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + A + + + + + + + + + + + + +| 47 |
Bacterium | | 1 2.0|
Concretion | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 5| 4| 7| 7| 7| 6| 0| 7| 5| 4| 7| 7| 6| 5| 4| 7| |
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 8| 6| 5| 3| 3| 3| 2| 2| 3| 7| 5| 3| 1| 0| 4| 1| 3| |
| 1| 1| 1| 1| 5| 2| 2| 2| 5| 4| 6| 2| 2| 2| 3| 6| 2| 8| 6| 2| 7| 0| 3| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Artery, Necrosis, Fibrinoid | 2 | 1 2.0|
Seminiferous Tubule, Atrophy | | 2 1.5|
Seminiferous Tubule, Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + A + + + + + + + + + + + + +| 46 |
Axillary, Angiectasis | | 1 2.0|
Axillary, Infiltration Cellular, | | |
Lymphocyte | | 1 2.0|
Lumbar, Hematopoietic Cell | | |
Proliferation | 2 | 1 2.0|
Renal, Hematopoietic Cell | | |
Proliferation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + M + M A M + + M M + M M + M + + +| 25 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + + + + + A + + + + + + + + + + + + +| 44 |
Angiectasis | 2 2 1 3 3 2 2 3 1 2| 22 1.8|
Hematopoietic Cell Proliferation | 1 3 1 2 1 2 | 15 1.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + A + + + + + + + + + + + + +| 47 |
Angiectasis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 1 2 1 3 2 3 3 3 3 1 1 3 1 1 2 1 1 3 3 | 38 1.8|
__________________________________________________________________________|____________|
Thymus | M + M + + M M M + + A + M + + M + + + + + + + +| 36 |
Atrophy | 3 3 | 3 2.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M + M M M M M M M + M M M M + M M M| 5 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Acanthosis | 1 2| 2 1.5|
Hemorrhage | 2 | 2 2.0|
Necrosis | 3 2 3 | 6 2.2|
Prepuce, Hemorrhage | | 1 2.0|
Prepuce, Inflammation, Acute | 3 | 2 3.0|
Prepuce, Necrosis | | 2 4.0|
Scrotal, Epithelium, Hyperplasia, | | |
Basal Cell | | 1 2.0|
Subcutaneous Tissue, Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 5| 4| 7| 7| 7| 6| 0| 7| 5| 4| 7| 7| 6| 5| 4| 7| |
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 8| 6| 5| 3| 3| 3| 2| 2| 3| 7| 5| 3| 1| 0| 4| 1| 3| |
| 1| 1| 1| 1| 5| 2| 2| 2| 5| 4| 6| 2| 2| 2| 3| 6| 2| 8| 6| 2| 7| 0| 3| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Tarsal, Hyperostosis | 3 3 4 1 3 2 2 2 | 23 2.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Mineralization | 1 | 4 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + A + + + + + + + + + + + + +| 47 |
Atelectasis | 2 | 1 2.0|
Congestion | | 2 1.5|
Edema | 2 | 1 2.0|
Hemorrhage | 2 3 1 2 | 6 1.7|
Infiltration Cellular, Histiocyte | 1 | 3 1.0|
Inflammation, Chronic Active | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 2 1.5|
__________________________________________________________________________|____________|
Nose | + M + + + M + + + + A + + + + M + + + + + + + +| 40 |
Inflammation, Acute | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + A + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + A + + + + + + + + + + + + +| 47 |
Congestion | | 1 2.0|
Cyst | | 1 |
Fibrosis | | 1 1.0|
Inflammation, Acute | | 1 2.0|
Cortex, Mineralization | 1 1 1 1 | 12 1.2|
Papilla, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + A + + + + + + + + + + + + +| 45 |
Calculus Micro Observation Only | X | 2 |
Inflammation, Chronic Active | | 2 1.5|
Transitional Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 4| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 9| 2| 3| 8| 2| 5| 5|
| 0| 0| 0| 3| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 0| 1| 1| 5| 8| 0| 1| 2| 2| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + A A A + +|
__________________________________________________________________________|
Intestine Large | + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + A + A|
__________________________________________________________________________|
Intestine Large, Colon | + + A A + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A A A + A|
__________________________________________________________________________|
Intestine Small | + + A A A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A A A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A A A + A|
Lymphoid Nodule, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A A A + A|
Lymphoid Nodule, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | |
Hemorrhage | 3|
Necrosis | 2 3 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Mineralization | |
Fat, Necrosis | 4 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + A + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + A + +|
Acanthosis | |
Hyperkeratosis | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + A A + +|
Inflammation, Chronic Active | 2 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + +|
Capsule, Hyperplasia | 1 2 1 2 1 1 1 1 1 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + +|
Hyperplasia | 2|
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + M M M +|
__________________________________________________________________________|
Pituitary Gland | + M + + + +|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 4| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 9| 2| 3| 8| 2| 5| 5|
| 0| 0| 0| 3| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 0| 1| 1| 5| 8| 0| 1| 2| 2| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + +|
__________________________________________________________________________|
Penis | +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + |
Dilatation | 3 3 3 |
Inflammation, Chronic Active | 2 1 |
Mineralization | |
Necrosis | 3 2 |
__________________________________________________________________________|
Prostate | + + + A + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + A + +|
__________________________________________________________________________|
Testes | + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + A + + + +|
Iliac, Cyst | |
Mediastinal, Hematopoietic Cell | |
Proliferation | 2 |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 2 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 2 |
Pancreatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M M M M M|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + A + + + +|
Angiectasis | 1 3 1 3 2 2 2 2 1 2 2|
Hematopoietic Cell Proliferation | 1 3 2 2 2 2 2|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Hematopoietic Cell Proliferation | 3 3 4 2 3 2 3 |
Hemorrhage | 2 |
__________________________________________________________________________|
Thymus | + + + M A + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M|
__________________________________________________________________________|
Skin | M + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 4| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 9| 2| 3| 8| 2| 5| 5|
| 0| 0| 0| 3| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 0| 1| 1| 5| 8| 0| 1| 2| 2| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Prepuce, Hemorrhage | 2|
Prepuce, Inflammation, Acute | 1 |
Prepuce, Inflammation, Chronic Active| |
Prepuce, Necrosis | |
Subcutaneous Tissue, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + +|
Joint, Hyperostosis | 2 |
Tarsal, Hyperostosis | 2 2 3 3 3 3 2 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 1 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + M +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + +|
Casts Protein | 1 |
Cortex, Mineralization | 2 1 |
Papilla, Mineralization | 1 |
Renal Tubule, Regeneration | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + +|
Calculus Gross Observation | X X |
Calculus Micro Observation Only | X X X |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 5| 0| 6| 3| 3| 3| 3| 3| |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 5| 0| 9| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + + A | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 7 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M A | 3 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + A | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A | 5 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A | 6 |
Lymphoid Nodule, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A | 7 |
Lymphoid Nodule, Hyperplasia | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + | 24 |
Angiectasis | 2 | 2 2.0|
Cyst | X | 1 |
Hemorrhage | | 1 3.0|
Necrosis | 1 | 3 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Fat, Mineralization | 3 | 1 3.0|
Fat, Necrosis | 4 | 4 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 13 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 9 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 2 | 1 2.0|
Hyperkeratosis | 2 2 1 1 | 4 1.5|
Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Inflammation, Chronic Active | 1 2 2 2 | 6 1.7|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + | 9 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + | 13 |
Capsule, Hyperplasia | 1 2 1 | 13 1.3|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + | 13 |
Hyperplasia | | 1 2.0|
Hypertrophy | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 5| 0| 6| 3| 3| 3| 3| 3| |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 5| 0| 9| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + | 13 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 13 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M | 3 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 8 |
__________________________________________________________________________|____________|
Thyroid Gland | + + M | 8 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + | 9 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + | 19 |
Dilatation | 2 2 | 5 2.6|
Inflammation, Chronic Active | 2 2 3 2 | 6 2.0|
Mineralization | 1 | 1 1.0|
Necrosis | 2 2 3 2 | 6 2.3|
__________________________________________________________________________|____________|
Prostate | + + + | 8 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 11 |
__________________________________________________________________________|____________|
Testes | + + + | 9 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 9 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + M | 23 |
Iliac, Cyst | X | 1 |
Mediastinal, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Pancreatic, Angiectasis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M | 22 |
Angiectasis | 2 2 1 2 4 3 2 | 18 2.1|
Hematopoietic Cell Proliferation | 1 2 2 | 10 1.9|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + +| 26 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 5| 0| 6| 3| 3| 3| 3| 3| |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 5| 0| 9| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Atrophy | | 1 4.0|
Hematopoietic Cell Proliferation | 2 2 2 2 2 | 12 2.5|
Hemorrhage | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + M | 7 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 22 |
Inflammation, Acute | | 1 2.0|
Necrosis | 1 2 2 | 3 1.7|
Prepuce, Hemorrhage | | 1 2.0|
Prepuce, Inflammation, Acute | 2 | 2 1.5|
Prepuce, Inflammation, Chronic Active| 3 | 1 3.0|
Prepuce, Necrosis | 2 2 | 2 2.0|
Subcutaneous Tissue, Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + | 31 |
Joint, Hyperostosis | 3 | 2 2.5|
Tarsal, Hyperostosis | 3 4 2 3 4 3 2 4 4 1 1 1 3 | 21 2.7|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 9 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + | 17 |
Congestion | | 1 2.0|
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 1 | 3 1.3|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + M | 7 |
__________________________________________________________________________|____________|
Trachea | + + + + + + | 17 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 13 |
Casts Protein | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 5| 0| 6| 3| 3| 3| 3| 3| |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 5| 0| 9| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Cortex, Mineralization | 1 | 3 1.3|
Papilla, Mineralization | | 1 1.0|
Renal Tubule, Regeneration | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 15 |
Calculus Gross Observation | X X | 4 |
Calculus Micro Observation Only | X X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 0| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 5| 1| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9|
| 9| 9| 2| 4| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 9| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Gallbladder | + + A + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large | + + A + + + + + + + + + + + + + + + + + M + + + +|
Anus, Necrosis | |
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Small | + + A + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + M + + + +|
Lymphoid Nodule, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + M + + + +|
Lymphoid Nodule, Hyperplasia | |
__________________________________________________________________________|
Liver | + + A + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Cyst | |
Fibrosis | 1 |
Mixed Cell Focus | |
Necrosis | 1 3 |
__________________________________________________________________________|
Mesentery | |
Fat, Mineralization | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + M + + + + + + + + + + + + + + + + + M + + + +|
Acinus, Atrophy | 1 |
__________________________________________________________________________|
Salivary Glands | + + A + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + M + + + + + + + M + + + +|
Hyperkeratosis | 1 1 |
__________________________________________________________________________|
Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 1 1 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 1 1 1 1 1 2 2 1 1 2 2 2 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + M + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hyperplasia | 1 1 |
Hypertrophy | 1 2 1 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + M + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 0| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 5| 1| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9|
| 9| 9| 2| 4| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 9| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + M + + + + + + + + M + + + + + + + + M + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + M + + M + + + M M + + + + M + + M + M + M M M|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + M + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X X |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + M + + + + + + + + + + + + + + + + + M + + + M|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + +|
Atrophy | 2 |
Dilatation | 3 3 3 2|
Inflammation, Acute | 3 |
Inflammation, Chronic Active | 1 |
Necrosis | 3 |
__________________________________________________________________________|
Prostate | + + A + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2|
__________________________________________________________________________|
Seminal Vesicle | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + A + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | 1 |
Seminiferous Tubule, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + M + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M M M M + M + + + + + + M + M M + M M + M + +|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + M + + + + + + + + + + + + + M + + + +|
Angiectasis | 2 2 2 2 3 1 3 1 2 2 2 3 1 3 3|
Hematopoietic Cell Proliferation | 2 1 2 1 2 2 2 2 2 1 2 1 3|
Hemorrhage | 1 |
__________________________________________________________________________|
Spleen | + + M + + + + + + + + + + + + + + + + + M + + + +|
Angiectasis | |
Depletion Lymphoid | 3|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 2 2 3 1 1 1 1 2 1 2 3 2 1 2 1 1 |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + M + M + + + +|
Depletion Lymphoid | 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M + + M M M M + M + M M M M + M + M M M|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 0| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 5| 1| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9|
| 9| 9| 2| 4| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 9| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + M + + + + + + + + + + + + + M M + + + +|
Acanthosis | 2 |
Hyperkeratosis | |
Inflammation, Acute | |
Mineralization | |
Necrosis | 3 1 |
Prepuce, Fibrosis | |
Prepuce, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Tarsal, Hyperostosis | 2 2 2 3 2 3 2 2 3 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + |
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + A + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 |
Congestion | 1 |
Inflammation, Acute | 3|
Cortex, Mineralization | 1 1 1 1 |
Papilla, Mineralization | |
Papilla, Necrosis | 1|
__________________________________________________________________________|
Urinary Bladder | + + A + + + + + + + + + + + + + + + + + M + + + +|
Angiectasis | 2 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 0| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 5| 1| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9|
| 9| 9| 2| 4| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 9| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Calculus Gross Observation | X |
Calculus Micro Observation Only | X X X |
Inflammation, Chronic Active | 2|
Mineralization | 1|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 9| 6| 3| 3| 3| 3| 8| 3| 3| 3| 3| 8| 8| 3| 3| 3| 1| |
| 0| 0| 0| 0| 0| 0| 0| 0| 4| 4| 0| 0| 0| 0| 2| 0| 0| 0| 0| 2| 2| 0| 0| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + M + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
Anus, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + M + + + + + + + A + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
Lymphoid Nodule, Hyperplasia | 3 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
Lymphoid Nodule, Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Clear Cell Focus | X | 1 |
Cyst | X X | 2 |
Fibrosis | | 1 1.0|
Mixed Cell Focus | X X | 2 |
Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
Fat, Mineralization | 2 | 1 2.0|
Fat, Necrosis | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
Acinus, Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + A + M + + + + + + + +| 46 |
Hyperkeratosis | | 2 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
Hyperplasia | 1 | 1 1.0|
Inflammation, Chronic Active | 1 1 1 | 6 1.2|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
Capsule, Hyperplasia | 1 2 4 1 1 2 2 1 1 1 1 2 1 1 1 3 2 1 1 2 1 1| 45 1.4|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 9| 6| 3| 3| 3| 3| 8| 3| 3| 3| 3| 8| 8| 3| 3| 3| 1| |
| 0| 0| 0| 0| 0| 0| 0| 0| 4| 4| 0| 0| 0| 0| 2| 0| 0| 0| 0| 2| 2| 0| 0| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Accessory Adrenal Cortical Nodule | X | 1 |
Hyperplasia | 2 2 2 1| 6 1.5|
Hypertrophy | 1 1 1 2 1 3 1 3 | 13 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + M + + + + + + + + + +| 47 |
Hyperplasia | 1 1 1 1 1| 8 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + A + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M M M + + + + + M M + + + M + M M M + + M M + +| 27 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Cyst | X | 5 |
Pars Intermedia, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + A + + + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 18 |
Atrophy | | 1 2.0|
Dilatation | 3 2 3 3 3 | 9 2.8|
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic Active | 1 1 | 3 1.0|
Necrosis | 3 2 2 1 | 5 2.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Seminiferous Tubule, Atrophy | | 1 1.0|
Seminiferous Tubule, Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + M M M + M A M M M + + + + M M +| 28 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + A + + + + + + + + + M| 45 |
Angiectasis | 3 2 2 2 2 3 1 1 1 | 24 2.0|
Hematopoietic Cell Proliferation | 2 2 2 2 1 2 1 | 20 1.8|
Hemorrhage | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 9| 6| 3| 3| 3| 3| 8| 3| 3| 3| 3| 8| 8| 3| 3| 3| 1| |
| 0| 0| 0| 0| 0| 0| 0| 0| 4| 4| 0| 0| 0| 0| 2| 0| 0| 0| 0| 2| 2| 0| 0| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
Angiectasis | 1 | 1 1.0|
Depletion Lymphoid | | 1 3.0|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 1 2 2 3 1 1 2 2 2 1 2 2 2 1 2 2 1 2 3| 36 1.7|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + + + M + M M + + + + + M +| 42 |
Depletion Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M + M M + + M M M M M M M M M M M M M M| 9 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Acanthosis | | 1 2.0|
Hyperkeratosis | 2| 1 2.0|
Inflammation, Acute | 2 | 1 2.0|
Mineralization | 3| 1 3.0|
Necrosis | 2 3 | 4 2.3|
Prepuce, Fibrosis | 2 | 1 2.0|
Prepuce, Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Tarsal, Hyperostosis | 2 2 1 2 1 2 3 4 1 2 1 1 3 2 2| 25 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 1 2 | 4 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 2| 4 2.3|
Hemorrhage | 1 1 2 | 4 1.3|
Infiltration Cellular, Histiocyte | 3 2 | 3 2.3|
Inflammation, Chronic Active | 2| 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 1 | 3 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + A + + + + + + + + + M| 48 |
Inflammation, Acute | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05023-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 13:22:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 9| 6| 3| 3| 3| 3| 8| 3| 3| 3| 3| 8| 8| 3| 3| 3| 1| |
| 0| 0| 0| 0| 0| 0| 0| 0| 4| 4| 0| 0| 0| 0| 2| 0| 0| 0| 0| 2| 2| 0| 0| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + | 5 |
Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Casts Protein | | 1 1.0|
Congestion | 2 | 2 1.5|
Inflammation, Acute | | 1 3.0|
Cortex, Mineralization | 1 1 1 1| 8 1.0|
Papilla, Mineralization | 1 | 1 1.0|
Papilla, Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
Angiectasis | | 1 2.0|
Calculus Gross Observation | X | 2 |
Calculus Micro Observation Only | X X X X X | 8 |
Inflammation, Chronic Active | | 1 2.0|
Mineralization | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
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