TR 365 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/04/94
EXP: 05023 PENTAERYTHRITOL TETRANITRATE TIME: 02:15:30
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 55743
CONT: N01CP9561901 CAS: 78-11-5
PATHOLOGIST: K. MURTHY
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/04/94
EXP: 05023 PENTAERYTHRITOL TETRANITRATE TIME: 02:15:30
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 55743
CONT: N01CP9561901 CAS: 78-11-5
PATHOLOGIST: K. MURTHY
PENTAERYTHRITOL TETRANITRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 49 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 184 207 247 414 456 456 543 550 564 578 |
| 585 600 601 623 660 660 667 682 682 695 |
| 715 717 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.5% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 269 465 482 543 600 620 655 655 656 691 |
| 698 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5.0% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 30 182 564 592 614 652 660 682 682 690 |
| 694 717 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PENTAERYTHRITOL TETRANITRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 93.9 93.9 91.8 87.8 85.7 73.5 67.3 53.1 |
| | |
| | |
|2.5% | 100.0 100.0 98.0 98.0 98.0 94.0 92.0 90.0 82.0 76.0 |
| | |
| | |
|5.0% | 98.0 98.0 96.0 96.0 96.0 96.0 96.0 92.0 86.0 76.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 2.5% 5.0% |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 53.1% 76.0% 76.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.014N P=0.025N P=0.023N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 557.1 588.0 563.3 |
|NATURAL DEATHS (C) | (33.6) (37.5) (63.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 648.3 695.2 689.2 |
|(STANDARD ERROR) | (19.9) (12.2) (17.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PENTAERYTHRITOL TETRANITRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 338 396 522 549 637 648 654 689 694 696 |
| 716 729 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.5% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 5 421 521 523 568 568 579 586 630 634 |
| 662 670 674 674 688 696 714 718 728 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5.0% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 258 463 586 605 607 646 654 662 663 675 |
| 689 711 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PENTAERYTHRITOL TETRANITRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 98.0 96.0 96.0 94.0 92.0 86.0 76.0 |
| | |
| | |
|2.5% | 98.0 98.0 98.0 98.0 96.0 96.0 92.0 84.0 78.0 60.0 |
| | |
| | |
|5.0% | 100.0 100.0 98.0 98.0 98.0 96.0 96.0 92.0 82.0 76.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 2.5% 5.0% |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 76.0% 60.0% 76.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=1.000 P=0.127 P=1.000 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 605.7 599.4 601.6 |
|NATURAL DEATHS (C) | (37.1) (36.2) (36.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 700.2 677.7 699.2 |
|(STANDARD ERROR) | (11.5) (17.0) (11.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PENTAERYTHRITOL TETRANITRATE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
2.5% = 2
5.0% = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 1 2
|
| 3 31 1 2 2
| 3 1 1 2 2 3
95 +
| 1 1 2 2 3 3
| 2 32 3
| 1 1
90 + 2 32 3
|
| 1 1 2 2 3
| 11 3 3
P 85 +
E | 1 1
R | 2 32
C | 1 1
E 80 + 11 22
N |
T | 1 1 2 32
| 32 2
S 75 +
U | 1 1
R |
V | 1 1
I 70 +
V |
A | 11
L |
65 + 1 1
|
|
| 1 1
60 +
| 1 1
|
|
55 + 11
|
| 1 1
|
50 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 8 obs hidden.
PENTAERYTHRITOL TETRANITRATE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
2.5% = 2
5.0% = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 12 3 1
|
| 2 3 1 1 2 3
| 1 2 3 1 3
95 +
| 1 1 3 3
| 2 1 2 1
|
P 90 + 3 1 1
E |
R | 22 11
C | 22 1 3 1
E 85 +
N | 2 2 11
T | 22 3 3
|
S 80 + 2 2 3 31 1
U |
R | 22 3 31 1
V | 22 3 1
I 75 +
V |
A | 2 2
L |
70 + 22
|
| 2 2
| 22
65 +
| 22
|
|
60 + 2 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 8 obs hidden.
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