TR 365 Rat Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
PENTAERYTHRITOL TETRANITRATE
NTP Experiment-Test: 05023-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/04/94
Route: DOSED FEED Time: 00:40:07
Facility: TSI Mason Research
Chemical CAS #: 78-11-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05023-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 00:40:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.62% 1.25%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund 13 15 18
Dead 3 2 1
Natural Death 1
Survivors
Terminal Sacrifice 33 33 31
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (49) (44) (49)
Hyperkeratosis 1 (2%)
Intestine Large, Colon (48) (10) (50)
Parasite 5 (10%) 7 (14%)
Intestine Large, Rectum (46) (10) (48)
Parasite 1 (2%)
Intestine Small, Ileum (46) (13) (49)
Lymphoid Nodule, Hyperplasia 2 (15%) 1 (2%)
Intestine Small, Jejunum (47) (10) (49)
Lymphoid Nodule, Hyperplasia 1 (2%)
Liver (50) (50) (50)
Angiectasis 1 (2%) 2 (4%) 3 (6%)
Basophilic Focus 41 (82%) 41 (82%) 43 (86%)
Clear Cell Focus 1 (2%) 2 (4%) 1 (2%)
Congestion 1 (2%) 1 (2%)
Developmental Malformation 2 (4%) 3 (6%)
Eosinophilic Focus 1 (2%) 3 (6%) 1 (2%)
Fatty Change, Diffuse 6 (12%) 5 (10%) 4 (8%)
Fatty Change, Focal 4 (8%) 4 (8%) 8 (16%)
Focal Cellular Change 2 (4%) 3 (6%)
Hepatodiaphragmatic Nodule 2 (4%) 7 (14%) 3 (6%)
Hyperplasia 1 (2%) 2 (4%)
Inflammation, Chronic, Focal 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Mixed Cell Focus 3 (6%) 1 (2%) 3 (6%)
Necrosis 1 (2%) 2 (4%) 1 (2%)
Bile Duct, Hyperplasia 4 (8%) 2 (4%) 2 (4%)
Mesentery (3) (4) (4)
Artery, Inflammation, Chronic Active 1 (25%)
Artery, Pigmentation 1 (25%)
Artery, Thrombosis 1 (25%)
Fat, Hemorrhage 1 (33%) 1 (25%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05023-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 00:40:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.62% 1.25%
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Fat, Necrosis 2 (67%) 2 (50%) 3 (75%)
Fat, Pigmentation 1 (25%)
Pancreas (50) (17) (49)
Acinus, Atrophy 1 (2%) 1 (2%)
Artery, Inflammation, Chronic Active 1 (6%)
Pharynx (1) (1)
Palate, Epithelium, Hyperplasia 1 (100%)
Salivary Glands (50) (13) (49)
Inflammation, Acute 1 (8%)
Stomach, Forestomach (50) (11) (48)
Acanthosis 2 (4%) 1 (9%) 4 (8%)
Hyperkeratosis 2 (4%) 1 (9%) 7 (15%)
Inflammation, Chronic Active 2 (18%)
Necrosis 2 (18%) 1 (2%)
Stomach, Glandular (50) (11) (50)
Hyperplasia 4 (8%)
Infiltration Cellular, Lymphocyte 1 (2%)
Mineralization 2 (4%) 2 (4%)
Necrosis 1 (2%) 1 (9%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (10) (50)
Cardiomyopathy 28 (56%) 3 (30%) 23 (46%)
Artery, Necrosis, Fibrinoid 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (49) (12) (49)
Degeneration 1 (2%)
Hyperplasia 1 (2%) 2 (4%)
Necrosis 1 (2%)
Adrenal Gland, Medulla (49) (12) (49)
Hyperplasia 6 (12%) 1 (8%) 7 (14%)
Necrosis 1 (2%)
Pituitary Gland (50) (30) (49)
Hyperplasia 2 (4%)
Hyperplasia, Focal 1 (2%) 1 (2%)
Pars Distalis, Angiectasis 28 (56%) 18 (60%) 26 (53%)
Pars Distalis, Cyst 2 (4%) 3 (10%) 2 (4%)
Pars Distalis, Cyst, Multiple 1 (2%)
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia 15 (30%) 3 (10%) 16 (33%)
Pars Distalis, Pigmentation 2 (4%)
Pars Intermedia, Hyperplasia 2 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05023-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 00:40:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.62% 1.25%
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Nervosa, Cyst, Multiple 1 (2%)
Thyroid Gland (50) (48) (50)
Necrosis 1 (2%)
C-Cell, Hyperplasia 7 (14%) 9 (19%) 5 (10%)
Follicular Cell, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (39) (12) (41)
Dilatation 1 (2%)
Hyperplasia 3 (8%) 1 (8%) 2 (5%)
Inflammation, Acute 1 (8%)
Inflammation, Chronic Active 1 (3%) 2 (17%) 2 (5%)
Necrosis 7 (18%) 1 (8%) 3 (7%)
Ovary (50) (15) (50)
Cyst 4 (8%) 4 (27%) 3 (6%)
Uterus (50) (48) (50)
Necrosis 2 (4%)
Pigmentation 1 (2%)
Endometrium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (50) (17) (49)
Mediastinal, Angiectasis 1 (2%) 1 (6%)
Mediastinal, Congestion 1 (2%)
Mediastinal, Hemorrhage 1 (2%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (6%)
Mediastinal, Pigmentation 2 (4%) 3 (6%)
Pancreatic, Infiltration Cellular, Histiocyte 2 (12%)
Pancreatic, Pigmentation 1 (2%)
Renal, Angiectasis 1 (6%) 1 (2%)
Renal, Infiltration Cellular, Histiocyte 1 (6%)
Lymph Node, Mandibular (46) (11) (47)
Angiectasis 1 (2%)
Degeneration, Cystic 1 (9%)
Infiltration Cellular, Plasma Cell 1 (9%) 2 (4%)
Lymph Node, Mesenteric (49) (12) (48)
Angiectasis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05023-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 00:40:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.62% 1.25%
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Congestion 2 (4%)
Hemorrhage 1 (2%)
Infiltration Cellular, Histiocyte 1 (8%)
Necrosis 1 (2%)
Spleen (49) (26) (50)
Angiectasis 1 (2%)
Depletion Lymphoid 1 (2%) 1 (4%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 33 (67%) 12 (46%) 41 (82%)
Hemorrhage 1 (2%)
Hyperplasia, Reticulum Cell 1 (2%)
Necrosis 1 (2%) 1 (4%) 1 (2%)
Pigmentation 33 (67%) 10 (38%) 38 (76%)
Thymus (46) (10) (44)
Depletion Lymphoid 1 (2%)
Epithelial Cell, Hyperplasia 2 (4%) 2 (5%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (46) (34) (48)
Galactocele 35 (76%) 15 (44%) 32 (67%)
Acinus, Hyperplasia 1 (2%) 1 (3%) 3 (6%)
Skin (49) (15) (50)
Acanthosis 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Hyperkeratosis 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (10) (50)
Hemorrhage 1 (2%) 1 (2%)
Hydrocephalus 1 (10%)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05023-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 00:40:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.62% 1.25%
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Congestion 4 (8%) 30 (60%) 2 (4%)
Edema 1 (2%) 2 (4%)
Fibrosis 1 (2%)
Hemorrhage 6 (12%) 3 (6%) 5 (10%)
Infiltration Cellular, Histiocyte 5 (10%) 7 (14%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%)
Necrosis 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 2 (4%)
Goblet Cell, Hypertrophy 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (2) (2)
Acanthosis 1 (50%)
Hyperkeratosis 2 (100%)
Eye (6) (7) (5)
Cornea, Inflammation, Chronic Active 1 (20%)
Lens, Cataract 1 (14%)
Retina, Atrophy 2 (29%)
Harderian Gland (3) (3) (3)
Abscess 1 (33%)
Pigmentation 1 (33%)
Zymbal's Gland (36) (37) (35)
Cyst 1 (3%) 1 (3%)
Hyperplasia 1 (3%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Fibrosis 1 (2%)
Nephropathy 46 (92%) 39 (78%) 49 (98%)
Cortex, Mineralization 4 (8%) 1 (2%) 7 (14%)
Cortex, Necrosis 1 (2%)
Papilla, Mineralization 1 (2%) 4 (8%)
Pelvis, Mineralization 1 (2%) 1 (2%)
Renal Tubule, Hyperplasia 1 (2%) 1 (2%)
Renal Tubule, Pigmentation 1 (2%) 1 (2%) 2 (4%)
Transitional Epithelium, Hyperplasia 2 (4%)
Urinary Bladder (49) (10) (49)
Hemorrhage 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05023-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 00:40:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.62% 1.25%
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Inflammation, Chronic Active 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05023-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 00:40:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund 20 16 16
Dead 8 5 5
Survivors
Terminal Sacrifice 21 28 29
Moribund 1
Terminal Sacrifice 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (47) (10) (48)
Parasite 6 (13%) 2 (20%) 14 (29%)
Intestine Large, Rectum (46) (9) (48)
Parasite 1 (2%) 2 (4%)
Intestine Small, Ileum (47) (7) (47)
Lymphoid Tissue, Hyperplasia 1 (2%)
Liver (49) (50) (50)
Angiectasis 5 (10%) 7 (14%) 8 (16%)
Basophilic Focus 25 (51%) 19 (38%) 25 (50%)
Clear Cell Focus 2 (4%) 4 (8%) 3 (6%)
Congestion 1 (2%) 1 (2%)
Degeneration, Cystic 3 (6%) 6 (12%) 6 (12%)
Developmental Malformation 2 (4%) 1 (2%)
Eosinophilic Focus 1 (2%) 1 (2%)
Fatty Change, Diffuse 3 (6%) 1 (2%) 1 (2%)
Fatty Change, Focal 7 (14%) 4 (8%) 5 (10%)
Focal Cellular Change 2 (4%) 8 (16%)
Hemorrhage 2 (4%)
Hepatodiaphragmatic Nodule 4 (8%) 1 (2%)
Hyperplasia 3 (6%) 2 (4%)
Hyperplasia, Focal 1 (2%) 1 (2%) 5 (10%)
Hyperplasia, Multifocal 1 (2%) 1 (2%)
Inflammation 1 (2%)
Inflammation, Granulomatous 1 (2%)
Mixed Cell Focus 4 (8%) 9 (18%) 3 (6%)
Necrosis 3 (6%) 1 (2%) 4 (8%)
Pigmentation 1 (2%)
Thrombosis 2 (4%)
Vacuolization Cytoplasmic 1 (2%)
Bile Duct, Hyperplasia 39 (80%) 31 (62%) 35 (70%)
Oval Cell, Hyperplasia 1 (2%)
Mesentery (5) (2) (9)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05023-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 00:40:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hemorrhage 1 (11%)
Fat, Mineralization 2 (40%) 1 (11%)
Fat, Necrosis 2 (40%) 1 (50%) 6 (67%)
Fat, Pigmentation 3 (33%)
Pancreas (49) (49) (48)
Fibrosis 1 (2%)
Acinus, Atrophy 1 (2%) 2 (4%)
Acinus, Hyperplasia 3 (6%) 6 (12%) 2 (4%)
Acinus, Hyperplasia, Focal 1 (2%) 1 (2%)
Artery, Hemorrhage 1 (2%)
Artery, Inflammation, Chronic Active 2 (4%)
Artery, Mineralization 1 (2%)
Artery, Necrosis, Fibrinoid 4 (8%) 2 (4%) 1 (2%)
Duct, Hyperplasia 1 (2%)
Pharynx (1)
Palate, Epithelium, Hyperplasia 1 (100%)
Salivary Glands (48) (13) (49)
Inflammation, Chronic Active 1 (8%)
Stomach, Forestomach (49) (14) (48)
Acanthosis 3 (6%) 4 (29%) 2 (4%)
Edema 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Hyperkeratosis 4 (8%) 7 (15%)
Hyperplasia, Basal Cell 1 (2%)
Inflammation, Chronic 2 (14%)
Inflammation, Chronic Active 2 (4%) 1 (2%)
Necrosis 2 (4%)
Ulcer 2 (14%)
Stomach, Glandular (48) (15) (47)
Degeneration 1 (2%)
Erosion 3 (20%)
Hyperplasia 3 (6%)
Infiltration Cellular, Lymphocyte 2 (13%) 2 (4%)
Inflammation, Chronic 2 (13%)
Mineralization 1 (2%) 2 (4%)
Necrosis 1 (2%) 1 (7%) 1 (2%)
Pigmentation 1 (2%)
Tongue (2) (1)
Hyperkeratosis 1 (50%)
Tooth (1)
Gingiva, Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05023-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 00:40:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (15) (50)
Cardiomyopathy 37 (76%) 13 (87%) 47 (94%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%)
Thrombosis 3 (20%)
Artery, Mineralization 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (49) (18) (48)
Hemorrhage 1 (2%)
Hyperplasia 1 (2%) 2 (4%)
Hypertrophy 1 (6%)
Vacuolization Cytoplasmic, Diffuse 1 (2%)
Adrenal Gland, Medulla (49) (18) (48)
Hyperplasia 25 (51%) 5 (28%) 21 (44%)
Islets, Pancreatic (49) (45) (47)
Hyperplasia 2 (4%)
Hyperplasia, Focal 1 (2%)
Parathyroid Gland (40) (9) (42)
Hyperplasia 2 (5%)
Pituitary Gland (49) (20) (50)
Pars Distalis, Angiectasis 12 (24%) 11 (55%) 6 (12%)
Pars Distalis, Cyst 2 (4%)
Pars Distalis, Hyperplasia 10 (20%) 3 (15%) 21 (42%)
Pars Distalis, Hyperplasia, Focal 1 (2%)
Pars Intermedia, Hyperplasia 1 (2%) 1 (5%) 3 (6%)
Thyroid Gland (49) (15) (50)
C-Cell, Hyperplasia 4 (8%) 6 (12%)
Follicle, Cyst 1 (2%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Necrosis 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05023-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 00:40:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (48) (13) (50)
Mineralization 4 (8%)
Preputial Gland (46) (22) (50)
Dilatation 1 (2%) 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Acute 2 (9%)
Inflammation, Chronic Active 2 (4%) 3 (6%)
Necrosis 7 (15%) 1 (5%) 7 (14%)
Prostate (48) (13) (50)
Inflammation 1 (2%)
Inflammation, Chronic Active 12 (25%) 3 (23%) 9 (18%)
Mineralization 1 (2%)
Necrosis 1 (2%)
Pigmentation 1 (2%)
Epithelium, Hyperplasia 1 (2%) 4 (8%)
Seminal Vesicle (49) (23) (50)
Atrophy 3 (6%)
Testes (49) (50) (50)
Interstitial Cell, Hyperplasia 28 (57%) 23 (46%) 25 (50%)
Seminiferous Tubule, Atrophy 43 (88%) 32 (64%) 44 (88%)
Seminiferous Tubule, Mineralization 4 (8%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (48) (10) (50)
Hyperplasia, Reticulum Cell 1 (2%)
Lymph Node (48) (30) (50)
Axillary, Infiltration Cellular, Plasma Cell 1 (3%)
Inguinal, Infiltration Cellular, Plasma Cell 1 (3%)
Lumbar, Congestion 1 (2%)
Lumbar, Infiltration Cellular, Plasma Cell 1 (2%)
Lumbar, Infiltration Cellular, Histiocyte 1 (3%)
Lumbar, Pigmentation 1 (2%)
Mediastinal, Angiectasis 2 (4%) 2 (7%)
Mediastinal, Congestion 1 (2%)
Mediastinal, Depletion Lymphoid 1 (2%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (3%)
Mediastinal, Pigmentation 3 (6%) 1 (3%) 2 (4%)
Pancreatic, Angiectasis 1 (3%)
Pancreatic, Cyst 1 (2%)
Pancreatic, Depletion Lymphoid 1 (2%)
Pancreatic, Hematocyst 1 (2%)
Pancreatic, Hemorrhage 1 (2%)
Pancreatic, Infiltration Cellular, Plasma
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05023-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 00:40:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Cell 1 (2%) 1 (2%)
Pancreatic, Infiltration Cellular, Histiocyte 3 (10%) 1 (2%)
Renal, Infiltration Cellular, Histiocyte 2 (7%) 1 (2%)
Renal, Pigmentation 1 (2%) 2 (4%)
Lymph Node, Mandibular (46) (20) (49)
Angiectasis 1 (5%)
Cyst 4 (9%) 2 (4%)
Degeneration, Cystic 1 (5%) 1 (2%)
Erythrophagocytosis 1 (2%)
Hemorrhage 2 (4%)
Infiltration Cellular, Plasma Cell 2 (10%)
Lymph Node, Mesenteric (47) (15) (48)
Angiectasis 1 (7%) 1 (2%)
Degeneration, Cystic 1 (2%) 2 (4%)
Hemorrhage 1 (2%) 1 (7%) 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%) 1 (7%)
Infiltration Cellular, Histiocyte 2 (4%)
Necrosis 1 (2%)
Spleen (48) (36) (50)
Atrophy 1 (2%)
Congestion 2 (4%)
Depletion Lymphoid 1 (2%) 1 (3%) 2 (4%)
Fibrosis 1 (2%) 2 (6%) 2 (4%)
Hematopoietic Cell Proliferation 26 (54%) 14 (39%) 28 (56%)
Hemorrhage 4 (11%)
Mineralization 1 (3%)
Necrosis 1 (2%) 1 (3%)
Pigmentation 6 (13%) 2 (6%) 15 (30%)
Thrombosis 1 (3%)
Thymus (36) (17) (45)
Depletion Lymphoid 3 (8%) 1 (6%) 3 (7%)
Epithelial Cell, Hyperplasia 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (37) (9) (38)
Galactocele 4 (11%) 6 (16%)
Acinus, Hyperplasia 1 (3%) 1 (3%)
Skin (48) (18) (50)
Acanthosis 3 (6%) 4 (22%) 4 (8%)
Cyst Epithelial Inclusion 2 (11%)
Erosion 1 (2%)
Hemorrhage 1 (2%)
Hyperkeratosis 4 (8%) 4 (22%) 5 (10%)
Inflammation, Chronic Active 1 (2%)
Necrosis 2 (4%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05023-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 00:40:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (10) (50)
Tarsal, Hyperostosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (48) (50)
Hemorrhage 3 (6%) 1 (2%) 2 (4%)
Spinal Cord (1)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (28) (50)
Atelectasis 1 (2%) 1 (4%)
Congestion 10 (20%) 10 (36%) 11 (22%)
Edema 3 (6%) 1 (4%) 2 (4%)
Embolus Tumor 1 (2%)
Fibrosis 1 (2%)
Hemorrhage 6 (12%) 2 (7%) 6 (12%)
Infiltration Cellular, Histiocyte 4 (8%) 1 (4%) 11 (22%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (2%) 5 (10%)
Alveolar Epithelium, Hyperplasia 2 (4%) 1 (2%)
Nose (47) (10) (50)
Hemorrhage 1 (2%)
Inflammation, Acute 2 (4%) 8 (16%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Metaplasia, Osseous 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (5) (9) (6)
Cornea, Inflammation, Acute 1 (20%)
Lens, Cataract 1 (20%) 3 (33%) 1 (17%)
Zymbal's Gland (49) (45) (41)
Cyst 6 (12%) 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Granulomatous 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05023-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 00:40:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50)
Angiectasis 1 (2%)
Cyst 4 (8%) 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Hydronephrosis 2 (4%)
Necrosis 1 (2%)
Nephropathy 49 (100%) 49 (98%) 49 (98%)
Capsule, Fibrosis 1 (2%)
Cortex, Mineralization 5 (10%) 7 (14%)
Papilla, Mineralization 4 (8%) 1 (2%) 9 (18%)
Renal Tubule, Dilatation 1 (2%)
Renal Tubule, Hyperplasia 3 (6%)
Renal Tubule, Necrosis 1 (2%) 1 (2%)
Renal Tubule, Pigmentation 3 (6%) 1 (2%) 5 (10%)
Transitional Epithelium, Hyperplasia 2 (4%) 8 (16%) 3 (6%)
Urinary Bladder (46) (10) (48)
Calculus Gross Observation 1 (10%) 1 (2%)
Calculus Micro Observation Only 1 (2%) 2 (20%) 1 (2%)
Fibrosis 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 1 (2%)
Artery, Necrosis, Fibrinoid 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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