TR 365 Rat Pathology Tables
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
Facility: TSI Mason Research
Chemical CAS #: 78-11-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 2| 5| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3|
| 7| 7| 7| 7| 3| 7| 7| 7| 9| 7| 8| 8| 7| 2| 7| 8| 9| 7| 8| 0| 8| 8| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + M A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Pharynx | |
Palate, Squamous Cell Carcinoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Pheochromocytoma Benign | |
Bilateral, Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + M + + M + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pars Distalis, Adenoma | X X X X X X X X |
Pars Distalis, Adenoma, Multiple | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X X X|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 2| 5| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3|
| 7| 7| 7| 7| 3| 7| 7| 7| 9| 7| 8| 8| 7| 2| 7| 8| 9| 7| 8| 0| 8| 8| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + M + + + + + M M M + + + + + M + + + + + +|
Adenoma | X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Polyp Stromal | X X |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | X X |
Deep Cervical, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | X |
Lumbar, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X X X X |
Pancreatic, Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + M M + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + A + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + M + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Adenoma | X |
Fibroadenoma | X X X X X X X|
Fibroadenoma, Multiple | X X X X X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + M + + + + + + + + + + + + +|
Keratoacanthoma | |
Subcutaneous Tissue, Fibroma | X |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 2| 5| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3|
| 7| 7| 7| 7| 3| 7| 7| 7| 9| 7| 8| 8| 7| 2| 7| 8| 9| 7| 8| 0| 8| 8| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Basosquamous Tumor Benign | |
__________________________________________________________________________|
Eye | + + + + |
__________________________________________________________________________|
Harderian Gland | + + |
__________________________________________________________________________|
Zymbal's Gland | + + + M + + + M + + + + + M + + M + + + + M M + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 3| 1| 0| 3| 3| 4| 2| 4| 3| 3| 3| 4| 1| 3| 3| 3| 3| 8| 3| 3| 3| 4| 6| |
| 8| 8| 8| 0| 4| 8| 8| 4| 8| 1| 8| 9| 9| 6| 0| 8| 8| 8| 9| 2| 9| 8| 8| 7| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + A + + + + + A + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A + + + + + A + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + A + + + + + A + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + + + + + A + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X | 14 |
__________________________________________________________________________|____________|
Mesentery | + | 3 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Pharynx | + | 1 |
Palate, Squamous Cell Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Leukemia Mononuclear | X X X | 7 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Leukemia Mononuclear | X X X | 7 |
Pheochromocytoma Benign | X | 1 |
Bilateral, Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + M M + + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 5
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 3| 1| 0| 3| 3| 4| 2| 4| 3| 3| 3| 4| 1| 3| 3| 3| 3| 8| 3| 3| 3| 4| 6| |
| 8| 8| 8| 0| 4| 8| 8| 4| 8| 1| 8| 9| 9| 6| 0| 8| 8| 8| 9| 2| 9| 8| 8| 7| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Adenoma | X X X X X X X X| 16 |
Pars Distalis, Adenoma, Multiple | X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, C-Cell, Adenoma | X | 2 |
C-Cell, Adenoma | X X | 5 |
C-Cell, Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + M + M + + M + + + + + + M + + + M + M + +| 39 |
Adenoma | X X X | 5 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 5 |
__________________________________________________________________________|____________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
Polyp Stromal | X X X X X X | 8 |
__________________________________________________________________________|____________|
Vagina | + + | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Axillary, Leukemia Mononuclear | X | 3 |
Deep Cervical, Leukemia Mononuclear | | 1 |
Inguinal, Leukemia Mononuclear | | 1 |
Lumbar, Leukemia Mononuclear | | 1 |
Mediastinal, Leukemia Mononuclear | X X | 6 |
Pancreatic, Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Leukemia Mononuclear | X X X | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X | 7 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X X X | 13 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + + + + + + + M + + + + + +| 46 |
Leukemia Mononuclear | X X X | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 3| 1| 0| 3| 3| 4| 2| 4| 3| 3| 3| 4| 1| 3| 3| 3| 3| 8| 3| 3| 3| 4| 6| |
| 8| 8| 8| 0| 4| 8| 8| 4| 8| 1| 8| 9| 9| 6| 0| 8| 8| 8| 9| 2| 9| 8| 8| 7| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + + M + + + + + + M + + + + + + + + +| 46 |
Adenoma | | 1 |
Fibroadenoma | X X X X X X X X X X X | 18 |
Fibroadenoma, Multiple | X X X X | 9 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Keratoacanthoma | X | 1 |
Subcutaneous Tissue, Fibroma | X X X | 4 |
Subcutaneous Tissue, Fibrosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Spinal Cord | +| 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X | 2 |
Leukemia Mononuclear | X X X X | 8 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + | 2 |
Basosquamous Tumor Benign | X | 1 |
__________________________________________________________________________|____________|
Eye | + +| 6 |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + M M + M + + M + + + M + M + + + M M +| 36 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 7 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 3| 1| 0| 3| 3| 4| 2| 4| 3| 3| 3| 4| 1| 3| 3| 3| 3| 8| 3| 3| 3| 4| 6| |
| 8| 8| 8| 0| 4| 8| 8| 4| 8| 1| 8| 9| 9| 6| 0| 8| 8| 8| 9| 2| 9| 8| 8| 7| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Leukemia Mononuclear | X X X X X X X X X X | 14 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 9| 8|
| 7| 7| 7| 8| 9| 7| 7| 7| 2| 5| 7| 7| 7| 7| 5| 7| 7| 7| 3| 9| 7| 7| 7| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.62% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + +|
__________________________________________________________________________|
Intestine Small | + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Skin | |
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + +|
Acinus, Adenoma | X |
__________________________________________________________________________|
Salivary Glands | + + + + +|
Leukemia Mononuclear | X|
__________________________________________________________________________|
Stomach | + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + +|
Leukemia Mononuclear | X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X |
Pars Distalis, Adenoma, Multiple | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
C-Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 9| 8|
| 7| 7| 7| 8| 9| 7| 7| 7| 2| 5| 7| 7| 7| 7| 5| 7| 7| 7| 3| 9| 7| 7| 7| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.62% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + M + +|
Adenoma | X |
Carcinoma | X |
Bilateral, Adenoma | X |
__________________________________________________________________________|
Ovary | + + + + +|
Granulosa Cell Tumor Benign | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Polyp Stromal | X X |
Bilateral, Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + +|
Mediastinal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | M M + + M|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Fibroadenoma | X X X X X X X X |
Fibroadenoma, Multiple | X X |
__________________________________________________________________________|
Skin | + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Fibrous | |
Histiocytoma | |
Subcutaneous Tissue, Hemangioma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 9| 8|
| 7| 7| 7| 8| 9| 7| 7| 7| 2| 5| 7| 7| 7| 7| 5| 7| 7| 7| 3| 9| 7| 7| 7| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.62% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + +|
Astrocytoma Malignant | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Spinal Cord | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Fibrous Histiocytoma, Metastatic, | |
Skin | |
Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Nose | + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + +|
Fibrosarcoma | X |
__________________________________________________________________________|
Eye | + + + +|
__________________________________________________________________________|
Harderian Gland | + + |
__________________________________________________________________________|
Zymbal's Gland | M M M M + M + + + + + + M + + + + + + + M + + M +|
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 2| 7| 7| 5| 5| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 7| 4| 0| 3| 3| 8| 4| 4| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| |
| 7| 7| 3| 1| 0| 7| 7| 5| 7| 3| 7| 7| 7| 7| 8| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.62% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + M + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 10 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + +| 14 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + | 11 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + +| 13 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | X | 1 |
Leukemia Mononuclear | X X X X X X | 14 |
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 17 |
Acinus, Adenoma | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 13 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + | 11 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + | 11 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 10 |
Leukemia Mononuclear | X X | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 12 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 12 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 17 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M M + + + + M + + + + + + + + +| 36 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + +| 30 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 2| 7| 7| 5| 5| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 7| 4| 0| 3| 3| 8| 4| 4| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| |
| 7| 7| 3| 1| 0| 7| 7| 5| 7| 3| 7| 7| 7| 7| 8| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.62% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 1 |
Pars Distalis, Adenoma | X X X X X X X X | 13 |
Pars Distalis, Adenoma, Multiple | X| 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
C-Cell, Adenoma | X X| 3 |
C-Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + M M + + + + | 12 |
Adenoma | X X X | 4 |
Carcinoma | | 1 |
Bilateral, Adenoma | X | 2 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 15 |
Granulosa Cell Tumor Benign | X | 1 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Oviduct | + | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X | 2 |
Polyp Stromal | X X X X X X X | 9 |
Bilateral, Polyp Stromal | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + | 17 |
Mediastinal, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + | 11 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 12 |
Leukemia Mononuclear | X X X | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + | 26 |
Leukemia Mononuclear | X X X X X X | 14 |
__________________________________________________________________________|____________|
Thymus | + + + + + M | 10 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + + + + + + + + + + + + | 34 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 2| 7| 7| 5| 5| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 7| 4| 0| 3| 3| 8| 4| 4| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| |
| 7| 7| 3| 1| 0| 7| 7| 5| 7| 3| 7| 7| 7| 7| 8| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.62% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Adenocarcinoma | | 1 |
Fibroadenoma | X X X X X X X | 15 |
Fibroadenoma, Multiple | X X X X X X | 8 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + +| 15 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Fibrous | | |
Histiocytoma | X | 1 |
Subcutaneous Tissue, Hemangioma | X| 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 10 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 10 |
Astrocytoma Malignant | X | 1 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X | 1 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | X | 1 |
Leukemia Mononuclear | X X X X | 8 |
__________________________________________________________________________|____________|
Nose | + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + +| 39 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
Fibrosarcoma | | 1 |
__________________________________________________________________________|____________|
Eye | + + + | 7 |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + M + + + + + + M M M M + + + + + + + + +| 37 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 2| 7| 7| 5| 5| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 7| 4| 0| 3| 3| 8| 4| 4| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| |
| 7| 7| 3| 1| 0| 7| 7| 5| 7| 3| 7| 7| 7| 7| 8| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.62% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X X | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 10 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X | 14 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 3| 4| 3| 3| 3| 0| 6| 3| 3| 0| 8| 4|
| 5| 5| 5| 5| 4| 5| 5| 5| 4| 8| 5| 5| 5| 5| 1| 5| 5| 5| 8| 2| 6| 5| 9| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.25% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + M + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + M + + + + + + + + + + + +|
Adenocarcinoma | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Mesentery | + +|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Acinus, Adenoma | X |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + M + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + M + M + + + + + + + + M + + + M|
Adenoma | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pars Distalis, Adenoma | X X X X X X X X X X|
Pars Distalis, Adenoma, Multiple | X X X X |
Pars Distalis, Carcinoma | |
Pars Distalis, Leukemia Mononuclear | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 3| 4| 3| 3| 3| 0| 6| 3| 3| 0| 8| 4|
| 5| 5| 5| 5| 4| 5| 5| 5| 4| 8| 5| 5| 5| 5| 1| 5| 5| 5| 8| 2| 6| 5| 9| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.25% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Sarcoma, Metastatic, Skin | |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X X |
Follicular Cell, Adenoma | |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + M + + + + + + + + + M + + M + + + + + M M|
Adenoma | X X X X |
Carcinoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma | X |
Leukemia Mononuclear | |
Polyp Stromal | X X X X X X |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + M + + + + + + + + + +|
Mediastinal, Leukemia Mononuclear | X X |
Pancreatic, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + M + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + M + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + + M + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + + M|
Adenocarcinoma | X |
Fibroadenoma | X X X X X X X X X X |
Fibroadenoma, Multiple | X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibroma | X |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 3| 4| 3| 3| 3| 0| 6| 3| 3| 0| 8| 4|
| 5| 5| 5| 5| 4| 5| 5| 5| 4| 8| 5| 5| 5| 5| 1| 5| 5| 5| 8| 2| 6| 5| 9| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.25% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Spinal Cord | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
__________________________________________________________________________|
Harderian Gland | + + |
__________________________________________________________________________|
Zymbal's Gland | + + M + + + + + + + + + + + + + + M M + + + M M M|
Adenoma | X |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 6| 9| 0| 3| 3| 0| 8| 8| 3| 3| 3| 3| 3| 3| 3| 3| 6| 8| |
| 6| 6| 6| 6| 3| 6| 5| 7| 6| 6| 6| 6| 1| 9| 0| 6| 6| 6| 6| 9| 6| 6| 6| 7| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
1.25% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A M + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenocarcinoma | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X | 9 |
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 1 |
Acinus, Adenoma | | 1 |
__________________________________________________________________________|____________|
Pharynx | + | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Sarcoma, Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + M + + + + + + + + + + + M + +| 48 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X | 6 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
Leukemia Mononuclear | X X | 2 |
Pheochromocytoma Benign | X X X | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| 44 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 6| 9| 0| 3| 3| 0| 8| 8| 3| 3| 3| 3| 3| 3| 3| 3| 6| 8| |
| 6| 6| 6| 6| 3| 6| 5| 7| 6| 6| 6| 6| 1| 9| 0| 6| 6| 6| 6| 9| 6| 6| 6| 7| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
1.25% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Adenoma | X X X X X X X X | 18 |
Pars Distalis, Adenoma, Multiple | X | 5 |
Pars Distalis, Carcinoma | X| 1 |
Pars Distalis, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sarcoma, Metastatic, Skin | X | 1 |
C-Cell, Adenoma | X X | 4 |
C-Cell, Carcinoma | X | 3 |
Follicular Cell, Adenoma | X | 1 |
Follicular Cell, Carcinoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + M M + + M + M + + + + + +| 41 |
Adenoma | X X | 6 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 3 |
__________________________________________________________________________|____________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leiomyosarcoma | | 1 |
Leukemia Mononuclear | X | 1 |
Polyp Stromal | X X X X X X | 12 |
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mediastinal, Leukemia Mononuclear | X X X | 5 |
Pancreatic, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + + + +| 47 |
Leukemia Mononuclear | X X | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 6| 9| 0| 3| 3| 0| 8| 8| 3| 3| 3| 3| 3| 3| 3| 3| 6| 8| |
| 6| 6| 6| 6| 3| 6| 5| 7| 6| 6| 6| 6| 1| 9| 0| 6| 6| 6| 6| 9| 6| 6| 6| 7| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
1.25% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + + + + + + + M + + + M + + M +| 44 |
Leukemia Mononuclear | X X X X | 6 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Adenocarcinoma | X | 2 |
Fibroadenoma | X X X X X X X X| 18 |
Fibroadenoma, Multiple | X X X X X | 11 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 3 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X | 8 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 5 |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
__________________________________________________________________________|____________|
Zymbal's Gland | + M + M M M + + + + M + M + + M + + + M M + + + +| 35 |
Adenoma | X | 2 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 6| 9| 0| 3| 3| 0| 8| 8| 3| 3| 3| 3| 3| 3| 3| 3| 6| 8| |
| 6| 6| 6| 6| 3| 6| 5| 7| 6| 6| 6| 6| 1| 9| 0| 6| 6| 6| 6| 9| 6| 6| 6| 7| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
1.25% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Leukemia Mononuclear | X X X X X X X | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 3| 4| 8| 3| 0| 8| 6| 6| 3| 3| 4| 3| 2| 3| 1| 3| 7| 7|
| 7| 7| 7| 7| 0| 7| 7| 8| 1| 9| 8| 2| 1| 0| 0| 7| 7| 0| 2| 5| 8| 1| 9| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + A +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + A +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X |
Neoplastic Nodule | |
__________________________________________________________________________|
Mesentery | + + |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Mesothelioma Malignant | X |
Mixed Tumor Benign | |
Acinus, Adenoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + A +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tongue | |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Benign | X X X X|
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 3| 4| 8| 3| 0| 8| 6| 6| 3| 3| 4| 3| 2| 3| 1| 3| 7| 7|
| 7| 7| 7| 7| 0| 7| 7| 8| 1| 9| 8| 2| 1| 0| 0| 7| 7| 0| 2| 5| 8| 1| 9| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Bilateral, Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M M + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pars Distalis, Adenoma | X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
C-Cell, Adenoma | X X X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + +|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + M + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + M + + + + + + + + +|
Adenoma | X X X |
Carcinoma | X X|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + M + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X X |
Tunic, Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | X |
Bronchial, Leukemia Mononuclear | |
Lumbar, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | X X |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Liposarcoma, Metastatic, Skin | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 3| 4| 8| 3| 0| 8| 6| 6| 3| 3| 4| 3| 2| 3| 1| 3| 7| 7|
| 7| 7| 7| 7| 0| 7| 7| 8| 1| 9| 8| 2| 1| 0| 0| 7| 7| 0| 2| 5| 8| 1| 9| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + M + + + M + + M M + + + + M + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + M M + + + + M + M + + M + M M + + + M +|
Adenocarcinoma | X |
Fibroadenoma | X X |
Fibroadenoma, Multiple | |
__________________________________________________________________________|
Skin | + + + + + + + + + + M + + + + + + + + + + + + + +|
Keratoacanthoma | |
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibroma | X X X |
Subcutaneous Tissue, Liposarcoma | |
Subcutaneous Tissue, Sarcoma | X |
Tail, Keratoacanthoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | |
Carcinoma Adenosquamous | |
Leukemia Mononuclear | X X X X X X |
Liposarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 3| 4| 8| 3| 0| 8| 6| 6| 3| 3| 4| 3| 2| 3| 1| 3| 7| 7|
| 7| 7| 7| 7| 0| 7| 7| 8| 1| 9| 8| 2| 1| 0| 0| 7| 7| 0| 2| 5| 8| 1| 9| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + M + M + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 1| 9| 4| 3| 1| 2| 6| 3| 3| 3| 4| 4| 1| 3| 3| 3| 1| 7| |
| 7| 7| 7| 7| 3| 7| 1| 1| 5| 1| 7| 1| 9| 4| 4| 7| 8| 6| 1| 5| 7| 8| 8| 8| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + M + + + + + + + + M + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large | + + + + M + + + + + + + + + + + + + + A + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + M + + + + + + + + + A + + + + A + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + M + + + + + + + + + + + + + + A + + + + +| 47 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + M + + + + + + + + + A + + + + A + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + M + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + M + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + M + + + + + + + + + + + + + + A + + + + +| 47 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + M + + + M + + + A + + + + + + A + + + + +| 45 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Hepatocellular Carcinoma | | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X| 29 |
Neoplastic Nodule | X X | 2 |
__________________________________________________________________________|____________|
Mesentery | + + + | 5 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X | 4 |
Mesothelioma Malignant | | 1 |
Mixed Tumor Benign | X | 1 |
Acinus, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + M + + + + + + + + + + + M + + + + + + + +| 48 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Tongue | + + | 2 |
Squamous Cell Papilloma | X X | 2 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X | 11 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 1| 9| 4| 3| 1| 2| 6| 3| 3| 3| 4| 4| 1| 3| 3| 3| 1| 7| |
| 7| 7| 7| 7| 3| 7| 1| 1| 5| 1| 7| 1| 9| 4| 4| 7| 8| 6| 1| 5| 7| 8| 8| 8| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X | 8 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X | 7 |
Pheochromocytoma Benign | X X X X X X X X| 12 |
Bilateral, Pheochromocytoma Benign | X X X X X | 7 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | X X X X | 6 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + M M M + M + + M + + + M +| 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X | 5 |
Pars Distalis, Adenoma | X X X X X X X X | 13 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 1 |
C-Cell, Adenoma | X X | 5 |
Follicular Cell, Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + + + + + | 9 |
__________________________________________________________________________|____________|
Epididymis | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + M M + + + + + + + + + + + + + + + + + + +| 46 |
Adenoma | X X X X X X X X | 11 |
Carcinoma | X| 3 |
__________________________________________________________________________|____________|
Prostate | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Testes | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X| 39 |
Interstitial Cell, Adenoma | X X X | 8 |
Tunic, Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + M + + + + + + + + + + + + + + A + + + + +| 48 |
Leukemia Mononuclear | X X X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 1| 9| 4| 3| 1| 2| 6| 3| 3| 3| 4| 4| 1| 3| 3| 3| 1| 7| |
| 7| 7| 7| 7| 3| 7| 1| 1| 5| 1| 7| 1| 9| 4| 4| 7| 8| 6| 1| 5| 7| 8| 8| 8| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
Axillary, Leukemia Mononuclear | | 1 |
Bronchial, Leukemia Mononuclear | X | 1 |
Lumbar, Leukemia Mononuclear | X | 1 |
Mediastinal, Leukemia Mononuclear | X X X X | 6 |
Pancreatic, Leukemia Mononuclear | X X X | 4 |
Renal, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + M + + + + + + +| 46 |
Leukemia Mononuclear | X X X X | 9 |
Liposarcoma, Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + A + + + +| 47 |
Leukemia Mononuclear | X X X X | 9 |
__________________________________________________________________________|____________|
Spleen | + + + + M + + + + + + + + + + + + + + A + + + + +| 48 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X| 28 |
__________________________________________________________________________|____________|
Thymus | + + + + M + + + M + + + + M M + + + A M + M + +| 36 |
Leukemia Mononuclear | X X | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + M + + + M + + + + + + + + + + M + + + + +| 37 |
Adenocarcinoma | | 1 |
Fibroadenoma | X | 3 |
Fibroadenoma, Multiple | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
Keratoacanthoma | X X X| 3 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Fibroma | X | 4 |
Subcutaneous Tissue, Liposarcoma | X | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
Tail, Keratoacanthoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 1| 9| 4| 3| 1| 2| 6| 3| 3| 3| 4| 4| 1| 3| 3| 3| 1| 7| |
| 7| 7| 7| 7| 3| 7| 1| 1| 5| 1| 7| 1| 9| 4| 4| 7| 8| 6| 1| 5| 7| 8| 8| 8| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Adenoma | X | 3 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Carcinoma Adenosquamous | X| 1 |
Leukemia Mononuclear | X X X X X X X X X | 15 |
Liposarcoma, Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + M + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Trachea | + + + + M + + + + + + + + + + + + + + A + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 5 |
__________________________________________________________________________|____________|
Zymbal's Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X | 6 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + M + + + + + + + + + + + + + + M + + + + +| 46 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X| 29 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 4| 2| 3| 3| 3| 3| 4| 3| 3| 1| 9| 4| 3| 3| 3| 3| 2| 3| 3| 1| 3| 6|
| 6| 6| 6| 1| 2| 6| 6| 6| 6| 0| 6| 6| 6| 5| 0| 7| 6| 6| 5| 3| 7| 0| 1| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + M +|
Leukemia Mononuclear | X|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + +|
Leukemia Mononuclear | X|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + M|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Acinus, Adenoma | X X X |
Acinus, Adenoma, Multiple | |
__________________________________________________________________________|
Salivary Glands | + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tongue | + |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
Pheochromocytoma Malignant | X X |
Pheochromocytoma Benign | X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + M +|
Adenoma | X |
Adenoma, Multiple | |
__________________________________________________________________________|
Parathyroid Gland | + M + + M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 4| 2| 3| 3| 3| 3| 4| 3| 3| 1| 9| 4| 3| 3| 3| 3| 2| 3| 3| 1| 3| 6|
| 6| 6| 6| 1| 2| 6| 6| 6| 6| 0| 6| 6| 6| 5| 0| 7| 6| 6| 5| 3| 7| 0| 1| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | X|
Pars Distalis, Adenoma | X X X X X X |
Pars Distalis, Adenoma, Multiple | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + +|
Leukemia Mononuclear | X |
C-Cell, Adenoma | |
Follicular Cell, Adenoma | X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + +|
Adenoma | X X X X X X |
Carcinoma | |
Bilateral, Adenoma | X |
Bilateral, Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X |
Tunic, Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + +|
Leukemia Mononuclear | X|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + +|
Iliac, Leukemia Mononuclear | X |
Lumbar, Leukemia Mononuclear | X X |
Mediastinal, Leukemia Mononuclear | X X X X X |
Pancreatic, Leukemia Mononuclear | X X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 4| 2| 3| 3| 3| 3| 4| 3| 3| 1| 9| 4| 3| 3| 3| 3| 2| 3| 3| 1| 3| 6|
| 6| 6| 6| 1| 2| 6| 6| 6| 6| 0| 6| 6| 6| 5| 0| 7| 6| 6| 5| 3| 7| 0| 1| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + M M + M + + + + + +|
Leukemia Mononuclear | X X X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + M|
Fibroadenoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + +|
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | X |
Scrotal, Fibroma | |
Subcutaneous Tissue, Fibroma | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Carcinoma, Metastatic, Zymbal's Gland| |
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Nose | + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Sarcoma | |
__________________________________________________________________________|
Eye | + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Harderian Gland | + + + |
__________________________________________________________________________|
Zymbal's Gland | M + + + + + + + + + M + + + + + M + + + + + + + +|
Adenoma | X |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
__________________________________________________________________________|
Urinary Bladder | + + + + + + +|
Leukemia Mononuclear | X|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 4| 2| 3| 3| 3| 3| 4| 3| 3| 1| 9| 4| 3| 3| 3| 3| 2| 3| 3| 1| 3| 6|
| 6| 6| 6| 1| 2| 6| 6| 6| 6| 0| 6| 6| 6| 5| 0| 7| 6| 6| 5| 3| 7| 0| 1| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Leukemia Mononuclear | X X X X X X X X X X X X X X X|
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 4| 3| 7| 3| 3| 9| 7| 5| 3| 3| 3| 3| 2| 3| 3| 3| 1| 0| 3| 3| 3| 7| 6| |
| 7| 7| 5| 7| 4| 7| 7| 6| 2| 8| 7| 7| 7| 7| 6| 7| 7| 7| 8| 1| 7| 7| 7| 4| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + M + +| 14 |
__________________________________________________________________________|____________|
Intestine Large | + + + +| 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + +| 8 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + +| 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + +| 9 |
__________________________________________________________________________|____________|
Intestine Small | + A + +| 9 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + +| 9 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + A| 7 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + +| 9 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X | 27 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 4 |
Acinus, Adenoma | X | 4 |
Acinus, Adenoma, Multiple | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + +| 13 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + +| 18 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + +| 14 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + + +| 15 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Tongue | | 1 |
Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + +| 15 |
Leukemia Mononuclear | X X | 7 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + +| 18 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + +| 18 |
Leukemia Mononuclear | X X | 6 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + +| 18 |
Leukemia Mononuclear | X X | 6 |
Pheochromocytoma Malignant | | 2 |
Pheochromocytoma Benign | X X X X | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 4| 3| 7| 3| 3| 9| 7| 5| 3| 3| 3| 3| 2| 3| 3| 3| 1| 0| 3| 3| 3| 7| 6| |
| 7| 7| 5| 7| 4| 7| 7| 6| 2| 8| 7| 7| 7| 7| 6| 7| 7| 7| 8| 1| 7| 7| 7| 4| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + A + + + + + + + +| 45 |
Adenoma | X | 2 |
Adenoma, Multiple | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + M + M| 9 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + +| 20 |
Leukemia Mononuclear | X X X | 4 |
Pars Distalis, Adenoma | X X X X X | 11 |
Pars Distalis, Adenoma, Multiple | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + +| 15 |
Leukemia Mononuclear | | 1 |
C-Cell, Adenoma | X X | 2 |
Follicular Cell, Adenoma | | 1 |
Follicular Cell, Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + +| 13 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + M + + +| 22 |
Adenoma | X X X X | 10 |
Carcinoma | X | 1 |
Bilateral, Adenoma | | 1 |
Bilateral, Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + +| 13 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + +| 23 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X| 36 |
Interstitial Cell, Adenoma | X X X X X | 8 |
Tunic, Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + +| 10 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + +| 30 |
Iliac, Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 36
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 4| 3| 7| 3| 3| 9| 7| 5| 3| 3| 3| 3| 2| 3| 3| 3| 1| 0| 3| 3| 3| 7| 6| |
| 7| 7| 5| 7| 4| 7| 7| 6| 2| 8| 7| 7| 7| 7| 6| 7| 7| 7| 8| 1| 7| 7| 7| 4| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lumbar, Leukemia Mononuclear | X | 3 |
Mediastinal, Leukemia Mononuclear | X X X X X X | 11 |
Pancreatic, Leukemia Mononuclear | X X X X | 6 |
Renal, Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + +| 20 |
Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + +| 15 |
Leukemia Mononuclear | X | 6 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + +| 36 |
Leukemia Mononuclear | X X X X X X X X X X X | 25 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + +| 17 |
Leukemia Mononuclear | X X X | 7 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M| 9 |
Fibroadenoma | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + +| 18 |
Squamous Cell Carcinoma | X | 1 |
Squamous Cell Papilloma | | 1 |
Scrotal, Fibroma | X | 1 |
Subcutaneous Tissue, Fibroma | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + +| 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Spinal Cord | +| 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + +| 28 |
Alveolar/Bronchiolar Adenoma | X X | 3 |
Carcinoma, Metastatic, Zymbal's Gland| X| 1 |
Leukemia Mononuclear | X X X X X X | 12 |
__________________________________________________________________________|____________|
Nose | + + + +| 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + +| 27 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 4| 3| 7| 3| 3| 9| 7| 5| 3| 3| 3| 3| 2| 3| 3| 3| 1| 0| 3| 3| 3| 7| 6| |
| 7| 7| 5| 7| 4| 7| 7| 6| 2| 8| 7| 7| 7| 7| 6| 7| 7| 7| 8| 1| 7| 7| 7| 4| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Eye | + + + +| 9 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + +| 7 |
__________________________________________________________________________|____________|
Zymbal's Gland | M + + + + + + + + + + + + + + M + + + + + + + + +| 45 |
Adenoma | | 1 |
Carcinoma | X| 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X | 18 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + A| 10 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X | 27 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 2| 6| 3| 2| 8| 7| 6| 3| 3| 3| 1| 8| 3| 8| 0| 0| 6| 3| 3| 3| 8| 4|
| 5| 5| 5| 2| 0| 5| 5| 0| 4| 2| 5| 5| 5| 1| 1| 5| 9| 9| 3| 9| 5| 5| 5| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
Neoplastic Nodule | |
__________________________________________________________________________|
Mesentery | + + + + + + + |
__________________________________________________________________________|
Pancreas | + + + + M + + + + + + + + + + + + + M + + + + + +|
Leukemia Mononuclear | |
Acinus, Adenoma | X |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + M + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Malignant | X X X |
Pheochromocytoma Benign | X X X X |
Bilateral, Pheochromocytoma Benign | X X|
__________________________________________________________________________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + M + + + + + +|
Adenoma | |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + M + M + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 2| 6| 3| 2| 8| 7| 6| 3| 3| 3| 1| 8| 3| 8| 0| 0| 6| 3| 3| 3| 8| 4|
| 5| 5| 5| 2| 0| 5| 5| 0| 4| 2| 5| 5| 5| 1| 1| 5| 9| 9| 3| 9| 5| 5| 5| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Adenoma, Multiple | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X X X X|
Carcinoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X X|
Tunic, Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | X X X |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Thymus | + + M + M + + + + + + + + + + + + + + + + M +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M M + M + + M + + + + M M + + + M + + + + M|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 2| 6| 3| 2| 8| 7| 6| 3| 3| 3| 1| 8| 3| 8| 0| 0| 6| 3| 3| 3| 8| 4|
| 5| 5| 5| 2| 0| 5| 5| 0| 4| 2| 5| 5| 5| 1| 1| 5| 9| 9| 3| 9| 5| 5| 5| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Adenocarcinoma | X |
Fibroadenoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | |
Keratoacanthoma | X |
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibroma, | |
Multiple | X |
Subcutaneous Tissue, Fibrosarcoma | X X |
Subcutaneous Tissue, Leukemia | |
Mononuclear | |
Tail, Keratoacanthoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | X |
Cerebellum, Carcinoma, Metastatic, | |
Zymbal's Gland | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Chondroma | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | + + + |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Renal Tubule, Adenoma | |
Renal Tubule, Carcinoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 2| 6| 3| 2| 8| 7| 6| 3| 3| 3| 1| 8| 3| 8| 0| 0| 6| 3| 3| 3| 8| 4|
| 5| 5| 5| 2| 0| 5| 5| 0| 4| 2| 5| 5| 5| 1| 1| 5| 9| 9| 3| 9| 5| 5| 5| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| |
| 6| 5| 5| 5| 7| 6| 6| 9| 7| 8| 6| 6| 6| 1| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + A| 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + M + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + A| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + A + + + + + + + + + + + + + + + + A| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X | 20 |
Neoplastic Nodule | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 9 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X | 3 |
Acinus, Adenoma | X X | 3 |
__________________________________________________________________________|____________|
Pharynx | +| 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X | 8 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
Leukemia Mononuclear | X X | 6 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
Leukemia Mononuclear | X X | 5 |
Pheochromocytoma Malignant | | 3 |
Pheochromocytoma Benign | X X X X X X X | 11 |
Bilateral, Pheochromocytoma Benign | X X| 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 |
Adenoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| |
| 6| 5| 5| 5| 7| 6| 6| 9| 7| 8| 6| 6| 6| 1| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M M + + + + + + + + + M M + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
Pars Distalis, Adenoma | X X X X X X | 11 |
Pars Distalis, Adenoma, Multiple | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
C-Cell, Adenoma | X X X X X | 7 |
C-Cell, Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + + + +| 6 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X X X X X X | 13 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X X X X| 42 |
Interstitial Cell, Adenoma | X | 7 |
Tunic, Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumbar, Leukemia Mononuclear | X | 1 |
Mediastinal, Leukemia Mononuclear | X X X X | 7 |
Pancreatic, Leukemia Mononuclear | X X | 2 |
Renal, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| |
| 6| 5| 5| 5| 7| 6| 6| 9| 7| 8| 6| 6| 6| 1| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X X | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X X X | 8 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X | 20 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Leukemia Mononuclear | X X X X | 6 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M M + M + + + + + + + M + + + + + + + + + +| 38 |
Adenocarcinoma | | 1 |
Fibroadenoma | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basal Cell Adenoma | X | 1 |
Keratoacanthoma | | 1 |
Squamous Cell Papilloma | X | 1 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Fibroma, | | |
Multiple | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 2 |
Subcutaneous Tissue, Leukemia | | |
Mononuclear | X | 1 |
Tail, Keratoacanthoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Astrocytoma Malignant | X | 2 |
Cerebellum, Carcinoma, Metastatic, | | |
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X | 4 |
Leukemia Mononuclear | X X X X X X | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Chondroma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 45
NTP Experiment-Test: 05023-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| |
| 6| 5| 5| 5| 7| 6| 6| 9| 7| 8| 6| 6| 6| 1| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 3 |
__________________________________________________________________________|____________|
Eye | + + + | 6 |
__________________________________________________________________________|____________|
Harderian Gland | + + + | 4 |
__________________________________________________________________________|____________|
Zymbal's Gland | + + M M M M M + M + + + + + + + + M + + + + + M +| 41 |
Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 4 |
Renal Tubule, Adenoma | X | 1 |
Renal Tubule, Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
Adenocarcinoma, Metastatic, Prostate | | 1 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X | 20 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
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